Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
FBXO44	93611	broad.mit.edu	37	1	11716012	11716012	+	Silent	SNP	C	C	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr1:11716012C>A	uc001asm.2	+	2	246	c.120C>A	c.(118-120)CTC>CTA	p.L40L	FBXO2_uc001asj.2_5'Flank|FBXO2_uc009vna.2_5'Flank|FBXO2_uc009vnb.1_5'Flank|FBXO44_uc001ask.2_Silent_p.L40L|FBXO44_uc010oaq.1_Silent_p.L40L|FBXO44_uc001asl.2_Silent_p.L40L|FBXO44_uc001asn.2_Silent_p.L40L|FBXO44_uc010oar.1_Silent_p.L40L|FBXO44_uc010oas.1_5'UTR	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	40	F-box.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GGCGGGACCTCATCGACCTCG	0.632000												
PRAMEF12	390999	broad.mit.edu	37	1	12836227	12836227	+	Missense_Mutation	SNP	T	T	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr1:12836227T>A	uc001aui.2	+	2	856	c.829T>A	c.(829-831)TCT>ACT	p.S277T		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	277										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCACTCTGTCTCTTTCCTCGA	0.498000												
YIPF1	54432	broad.mit.edu	37	1	54348919	54348919	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr1:54348919G>T	uc001cvu.2	-	4	399	c.62C>A	c.(61-63)GCA>GAA	p.A21E	YIPF1_uc001cvv.2_RNA|YIPF1_uc001cvw.2_RNA|YIPF1_uc001cvx.2_RNA|YIPF1_uc001cvy.2_RNA	NM_018982	NP_061855	Q9Y548	YIPF1_HUMAN	Yip1 domain family, member 1	21	Cytoplasmic (Potential).					integral to membrane|transport vesicle				large_intestine(1)|ovary(1)	2						ATCTGGGTTTGCTGTCAGAGA	0.453000												
KCNA3	3738	broad.mit.edu	37	1	111217025	111217025	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr1:111217025C>T	uc001dzv.1	-	1	631	c.407G>A	c.(406-408)CGC>CAC	p.R136H		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	136						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACCTCATGCGCCGCTTGGG	0.642000												
SPAG17	200162	broad.mit.edu	37	1	118616478	118616478	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr1:118616478T>C	uc001ehk.2	-	17	2452	c.2384A>G	c.(2383-2385)CAG>CGG	p.Q795R		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	795						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CATAAATACCTGAAGCAGTAC	0.239000												
FLG	2312	broad.mit.edu	37	1	152282723	152282723	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr1:152282723C>T	uc001ezu.1	-	3	4675	c.4639G>A	c.(4639-4641)GAG>AAG	p.E1547K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1547	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATTGTTCCTCATTTCTTGTT	0.587000									Ichthyosis			
PIK3C2B	5287	broad.mit.edu	37	1	204433201	204433201	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr1:204433201T>C	uc001haw.2	-	6	1728	c.1249A>G	c.(1249-1251)AGG>GGG	p.R417G	PIK3C2B_uc010pqv.1_Missense_Mutation_p.R417G|PIK3C2B_uc001hax.1_Missense_Mutation_p.R417G|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	417					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TCCACATTCCTCAGGTCATCA	0.547000												
OBSCN	84033	broad.mit.edu	37	1	228399516	228399516	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr1:228399516G>A	uc009xez.1	+	2	76	c.32G>A	c.(31-33)CGC>CAC	p.R11H	OBSCN_uc001hsn.2_Missense_Mutation_p.R11H|uc001hsm.1_Intron	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	11	Ig-like 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGGGCGCCCCGCTTTCTCACC	0.662000												
NSUN6	221078	broad.mit.edu	37	10	18835004	18835004	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr10:18835004C>T	uc010qcp.1	-	11	1686	c.1268G>A	c.(1267-1269)CGA>CAA	p.R423Q	NSUN6_uc001iqb.2_5'Flank	NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	423							methyltransferase activity|RNA binding			ovary(2)	2						TGGATCAAATCGCTGCAGCTG	0.488000												
ZNF488	118738	broad.mit.edu	37	10	48371149	48371149	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr10:48371149G>A	uc001jex.2	+	2	779	c.617G>A	c.(616-618)CGA>CAA	p.R206Q	ZNF488_uc001jey.2_Missense_Mutation_p.R99Q	NM_153034	NP_694579	Q96MN9	ZN488_HUMAN	zinc finger protein 488	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTTGGGGTCGACTTTCAACT	0.537000												
CDH23	64072	broad.mit.edu	37	10	73270759	73270759	+	Splice_Site	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr10:73270759G>A	uc001jrx.3	+	5	713	c.336_splice	c.e5+1	p.G112_splice	CDH23_uc001jrw.3_Splice_Site_p.G112_splice|CDH23_uc001jrv.2_Splice_Site_p.G107_splice|CDH23_uc009xql.2_Splice_Site_p.G157_splice	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor						calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CCACCAGGGGGTGAGTGTTCC	0.602000												
ZNF511	118472	broad.mit.edu	37	10	135123307	135123307	+	Silent	SNP	C	C	G			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr10:135123307C>G	uc001lml.1	+	3	280	c.255C>G	c.(253-255)GCC>GCG	p.A85A	TUBGCP2_uc001lmg.1_5'Flank|TUBGCP2_uc010qvc.1_5'Flank|TUBGCP2_uc009ybk.1_5'Flank|TUBGCP2_uc010qvd.1_5'Flank|TUBGCP2_uc001lmh.1_Intron|ZNF511_uc001lmj.1_Silent_p.A85A|ZNF511_uc001lmk.1_Silent_p.A85A|ZNF511_uc001lmm.1_RNA			Q8NB15	ZN511_HUMAN	SubName: Full=cDNA FLJ78327; SubName: Full=Zinc finger protein 511, isoform CRA_d;	85	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.56e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.15e-06)|Epithelial(32;9.99e-06)		GCCAGGTGGCCGGCTGCTGCC	0.617000												
PRB3	5544	broad.mit.edu	37	12	11420535	11420535	+	Missense_Mutation	SNP	T	T	G			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr12:11420535T>G	uc001qzs.2	-	3	686	c.648A>C	c.(646-648)CAA>CAC	p.Q216H	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	216	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|8.|Pro-rich.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GTGGGGGACCTTGGGACTGGT	0.622000												
NAV3	89795	broad.mit.edu	37	12	78444643	78444643	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr12:78444643G>T	uc001syp.2	+	11	2405	c.2232G>T	c.(2230-2232)TTG>TTT	p.L744F	NAV3_uc001syo.2_Missense_Mutation_p.L744F|NAV3_uc010sub.1_Missense_Mutation_p.L244F	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	744						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CCTGGAGGTTGGGCCAGGCAT	0.572000										HNSCC(70;0.22)		
SOS2	6655	broad.mit.edu	37	14	50666457	50666457	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr14:50666457A>T	uc001wxs.3	-	4	560	c.462T>A	c.(460-462)CAT>CAA	p.H154Q	SOS2_uc010tql.1_Missense_Mutation_p.H154Q	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	154					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					ATATTTCATAATGCCGGATAT	0.318000												
PTGDR	5729	broad.mit.edu	37	14	52734889	52734889	+	Silent	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr14:52734889G>A	uc001wzq.2	+	1	459	c.357G>A	c.(355-357)TCG>TCA	p.S119S		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	119	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	GGCTCTCCTCGACACTGCAAC	0.617000												
TP53BP1	7158	broad.mit.edu	37	15	43748491	43748491	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr15:43748491C>T	uc001zrs.2	-	12	2448	c.2300G>A	c.(2299-2301)AGA>AAA	p.R767K	TP53BP1_uc010udp.1_Missense_Mutation_p.R767K|TP53BP1_uc001zrq.3_Missense_Mutation_p.R772K|TP53BP1_uc001zrr.3_Missense_Mutation_p.R772K|TP53BP1_uc010udq.1_Missense_Mutation_p.R772K	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	767					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		AACATCAACTCTGGGAGATGG	0.453000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes				
SLC24A5	283652	broad.mit.edu	37	15	48429089	48429089	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr15:48429089G>A	uc001zwe.2	+	6	873	c.800G>A	c.(799-801)GGA>GAA	p.G267E	SLC24A5_uc010bel.2_Missense_Mutation_p.G207E|uc001zwf.1_5'Flank	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	267	Cytoplasmic (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		ACTGATAGTGGAATATTTTAT	0.413000												
PIGW	284098	broad.mit.edu	37	17	34893858	34893858	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr17:34893858G>T	uc002hmy.1	+	2	951	c.908G>T	c.(907-909)CGC>CTC	p.R303L	MYO19_uc010cuu.2_5'Flank|MYO19_uc010wcy.1_5'Flank|MYO19_uc010wcz.1_5'Flank|MYO19_uc010wda.1_5'Flank|MYO19_uc002hmx.2_5'Flank|PIGW_uc002hmz.1_Missense_Mutation_p.R303L	NM_178517	NP_848612	Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan, class W	303					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AATGCCAACCGCGAAGGAATA	0.433000												
KRT31	3881	broad.mit.edu	37	17	39553526	39553526	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr17:39553526C>T	uc002hwn.2	-	1	319	c.266G>A	c.(265-267)CGG>CAG	p.R89Q	KRT31_uc010cxn.2_Missense_Mutation_p.R89Q	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	89	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				AGACCGCTCCCGGATGAGGTT	0.587000												
LAMA1	284217	broad.mit.edu	37	18	7011407	7011407	+	Silent	SNP	C	C	G			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr18:7011407C>G	uc002knm.2	-	25	3673	c.3579G>C	c.(3577-3579)GGG>GGC	p.G1193G	LAMA1_uc010wzj.1_Silent_p.G669G	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	1193	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTAGTAAACCCCCTCGGTCG	0.607000												
ANKRD12	23253	broad.mit.edu	37	18	9204526	9204526	+	Silent	SNP	T	T	G			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr18:9204526T>G	uc002knv.2	+	4	545	c.288T>G	c.(286-288)TCT>TCG	p.S96S	ANKRD12_uc010wzn.1_Silent_p.S96S|ANKRD12_uc002knw.2_Intron|ANKRD12_uc002knx.2_Intron	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	96						nucleus				ovary(2)|central_nervous_system(1)	3						TTATATCTTCTTACAGGACAT	0.373000												
RNF165	494470	broad.mit.edu	37	18	44013236	44013236	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr18:44013236G>A	uc002lcb.1	+	2	196	c.145G>A	c.(145-147)GCT>ACT	p.A49T	RNF165_uc002lby.1_5'UTR|RNF165_uc010dnn.1_Intron	NM_152470	NP_689683	Q6ZSG1	RN165_HUMAN	ring finger protein 165	49							zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)		GCAGCAGCTCGCTCCCGACTT	0.706000												
CCBE1	147372	broad.mit.edu	37	18	57107014	57107014	+	Silent	SNP	G	G	A	rs151243930		TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr18:57107014G>A	uc002lib.2	-	8	880	c.810C>T	c.(808-810)CCC>CCT	p.P270P	CCBE1_uc010dpq.2_Intron|CCBE1_uc002lia.2_Silent_p.P123P	NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	270	Collagen-like 1.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				CTGGCATACCGGGGAAGCCTG	0.602000												
APBA3	9546	broad.mit.edu	37	19	3752514	3752514	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr19:3752514C>T	uc002lyp.1	-	8	1564	c.1387G>A	c.(1387-1389)GCT>ACT	p.A463T	APBA3_uc002lyo.1_Missense_Mutation_p.A221T	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	463	PDZ 1.				intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCGGACAGCGGCCTGGCAC	0.716000												
MAP2K7	5609	broad.mit.edu	37	19	7977041	7977041	+	Missense_Mutation	SNP	A	A	G			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr19:7977041A>G	uc002mit.2	+	10	1152	c.1087A>G	c.(1087-1089)AAA>GAA	p.K363E	MAP2K7_uc002miv.2_Missense_Mutation_p.K370E|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.K370E|MAP2K7_uc010dvv.2_Missense_Mutation_p.K238E	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	363	Protein kinase.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	TAGCCTTACTAAAGATCACAG	0.602000												
FBXL12	54850	broad.mit.edu	37	19	9922033	9922033	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr19:9922033G>A	uc002mme.2	-	3	762	c.520C>T	c.(520-522)CGC>TGC	p.R174C	FBXL12_uc002mmd.2_Missense_Mutation_p.R121C|FBXL12_uc002mmf.2_Missense_Mutation_p.R121C|FBXL12_uc002mmg.2_Missense_Mutation_p.R121C|FBXL12_uc002mmh.2_Missense_Mutation_p.R121C	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	174	LRR 4.						protein binding			lung(1)|kidney(1)	2						GCCCGGAAGCGCGTCAGGCCC	0.667000												
TSHZ3	57616	broad.mit.edu	37	19	31769921	31769921	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr19:31769921G>A	uc002nsy.3	-	2	843	c.778C>T	c.(778-780)CGC>TGC	p.R260C		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	260					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					AGCAAGGAGCGTTTGCGAGGC	0.557000												
LRFN3	79414	broad.mit.edu	37	19	36431169	36431169	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr19:36431169G>A	uc002oco.2	+	2	1294	c.842G>A	c.(841-843)CGC>CAC	p.R281H		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	281	LRRCT.|Extracellular (Potential).				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTGGGCGGCCGCTACTTCTGG	0.721000												
SIGLEC10	89790	broad.mit.edu	37	19	51920084	51920084	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr19:51920084G>A	uc002pwo.2	-	3	1158	c.542C>T	c.(541-543)ACG>ATG	p.T181M	SIGLEC10_uc002pwp.2_Intron|SIGLEC10_uc002pwq.2_Intron|SIGLEC10_uc002pwr.2_Missense_Mutation_p.T181M|SIGLEC10_uc010ycy.1_Missense_Mutation_p.T181M|SIGLEC10_uc010ycz.1_Intron|SIGLEC10_uc010eow.2_Translation_Start_Site|SIGLEC10_uc002pws.1_Intron	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	181	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GGCAGCCCCCGTCCAGGAGAA	0.612000												
ZNF835	90485	broad.mit.edu	37	19	57175776	57175776	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr19:57175776G>A	uc010ygo.1	-	2	857	c.857C>T	c.(856-858)GCG>GTG	p.A286V	ZNF835_uc010ygn.1_Missense_Mutation_p.A264V	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GCGGATGAGCGCTGAGGAGAA	0.672000												
ZNF418	147686	broad.mit.edu	37	19	58438782	58438782	+	Missense_Mutation	SNP	C	C	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr19:58438782C>A	uc002qqs.1	-	4	1059	c.767G>T	c.(766-768)AGA>ATA	p.R256I	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.R171I	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TTCATAAGGTCTTTTCCCAGT	0.423000												
LTBP1	4052	broad.mit.edu	37	2	33246091	33246091	+	Silent	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:33246091G>A	uc002ros.2	+	3	681	c.681G>A	c.(679-681)TCG>TCA	p.S227S		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	227					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGGACACCTCGTCACCAGTCT	0.552000												
EIF2AK2	5610	broad.mit.edu	37	2	37365428	37365428	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:37365428A>C	uc010ynh.1	-	8	1229	c.672T>G	c.(670-672)AGT>AGG	p.S224R	EIF2AK2_uc010fab.1_Missense_Mutation_p.S224R|EIF2AK2_uc010yng.1_Missense_Mutation_p.S224R|EIF2AK2_uc010fac.2_Missense_Mutation_p.S224R|EIF2AK2_uc010fad.2_Missense_Mutation_p.S224R	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	224					evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				GCAACGAAGAACTGTTTAAAC	0.363000												
GPR75	10936	broad.mit.edu	37	2	54080761	54080761	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:54080761C>T	uc002rxo.3	-	2	1404	c.1133G>A	c.(1132-1134)CGG>CAG	p.R378Q	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	378	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TGCACTGTTCCGAGAATATAT	0.423000												
COBLL1	22837	broad.mit.edu	37	2	165584554	165584554	+	Nonsense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:165584554G>A	uc010zcw.1	-	6	869	c.745C>T	c.(745-747)CAG>TAG	p.Q249*	COBLL1_uc002ucp.2_Nonsense_Mutation_p.Q196*|COBLL1_uc002ucq.2_Nonsense_Mutation_p.Q196*|COBLL1_uc010zcx.1_Nonsense_Mutation_p.Q242*|COBLL1_uc002ucs.1_RNA	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	234										ovary(2)|pancreas(1)	3						AGAGGCTCCTGCGATTGATAA	0.378000												
TTN	7273	broad.mit.edu	37	2	179418418	179418418	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:179418418C>T	uc010zfg.1	-	283	81834	c.81610G>A	c.(81610-81612)GAG>AAG	p.E27204K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E20899K|TTN_uc010zfi.1_Missense_Mutation_p.E20832K|TTN_uc010zfj.1_Missense_Mutation_p.E20707K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28131							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTCTTATCTCGACAACATAC	0.463000												
TTN	7273	broad.mit.edu	37	2	179659907	179659907	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:179659907C>G	uc010zfg.1	-	7	1211	c.987G>C	c.(985-987)AAG>AAC	p.K329N	TTN_uc010zfh.1_Missense_Mutation_p.K329N|TTN_uc010zfi.1_Missense_Mutation_p.K329N|TTN_uc010zfj.1_Missense_Mutation_p.K329N|TTN_uc002unb.2_Missense_Mutation_p.K329N|TTN_uc010frg.1_Missense_Mutation_p.K3N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	329							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGCCTGAGTCTTACGCATGA	0.547000												
DYTN	391475	broad.mit.edu	37	2	207528029	207528029	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:207528029C>A	uc002vbr.1	-	11	1348	c.1231G>T	c.(1231-1233)GGA>TGA	p.G411*		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	411						plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TAATCCCCTCCCTTTGGAACC	0.473000												
SPEG	10290	broad.mit.edu	37	2	220353344	220353344	+	Silent	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:220353344C>T	uc010fwg.2	+	33	7983	c.7983C>T	c.(7981-7983)AAC>AAT	p.N2661N		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2661	Ig-like 9.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CGGCCACCAACGTACTGGGCA	0.667000												
KIAA1486	57624	broad.mit.edu	37	2	226447619	226447619	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:226447619G>A	uc002voe.2	+	4	1661	c.1486G>A	c.(1486-1488)GGG>AGG	p.G496R	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.G266R	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	496										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GAACACCTACGGGGCAGCCCC	0.687000												
COL4A3	1285	broad.mit.edu	37	2	228124582	228124582	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:228124582G>A	uc002vom.1	+	19	1265	c.1103G>A	c.(1102-1104)CGT>CAT	p.R368H	COL4A3_uc002von.1_Missense_Mutation_p.R368H|COL4A3_uc002voo.1_Missense_Mutation_p.R368H|COL4A3_uc002vop.1_Missense_Mutation_p.R368H|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	368	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AGAGGAGCTCGTGGCCCACAA	0.418000												
ARMC9	80210	broad.mit.edu	37	2	232100085	232100085	+	Silent	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr2:232100085C>T	uc002vrq.3	+	8	883	c.771C>T	c.(769-771)AGC>AGT	p.S257S	ARMC9_uc002vrp.3_Silent_p.S257S	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	257							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CCACAGTCAGCGGCAAGATGG	0.483000												
STK4	6789	broad.mit.edu	37	20	43625835	43625835	+	Missense_Mutation	SNP	C	C	G			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr20:43625835C>G	uc002xnb.2	+	7	809	c.719C>G	c.(718-720)CCT>CGT	p.P240R	STK4_uc010ggx.2_Missense_Mutation_p.P240R|STK4_uc010ggy.2_Missense_Mutation_p.P185R|STK4_uc010ggw.1_Missense_Mutation_p.P240R	NM_006282	NP_006273	Q13043	STK4_HUMAN	serine/threonine kinase 4	240	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				CCTACAAATCCTCCTCCCACA	0.388000												
TH1L	51497	broad.mit.edu	37	20	57561860	57561860	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr20:57561860A>C	uc002yag.2	+	3	282	c.255A>C	c.(253-255)GAA>GAC	p.E85D	TH1L_uc010zzu.1_Missense_Mutation_p.E85D|TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Missense_Mutation_p.E85D	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	85					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)			TCTTATCTGAAAACTACACCG	0.507000												
PRPF6	24148	broad.mit.edu	37	20	62657327	62657327	+	Silent	SNP	C	C	T	rs151332876	by1000genomes	TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr20:62657327C>T	uc002yho.2	+	15	2112	c.1944C>T	c.(1942-1944)GCC>GCT	p.A648A	PRPF6_uc002yhp.2_Intron	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	648	HAT 6.				assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GGCTGGCAGCCGTGAAGCTGG	0.647000												
CECR2	27443	broad.mit.edu	37	22	17983950	17983950	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr22:17983950G>A	uc010gqw.1	+	6	772	c.646G>A	c.(646-648)GAG>AAG	p.E216K	CECR2_uc010gqv.1_Missense_Mutation_p.E95K|CECR2_uc002zml.2_Missense_Mutation_p.E95K|CECR2_uc002zmm.1_Missense_Mutation_p.E95K	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	258					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		ACAGGTCACCGAGAGTTTTCG	0.542000												
BSN	8927	broad.mit.edu	37	3	49680049	49680049	+	Missense_Mutation	SNP	A	A	C			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr3:49680049A>C	uc003cxe.3	+	3	1096	c.982A>C	c.(982-984)AGT>CGT	p.S328R		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	328					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCCGGCCAAAAGTGCCACCGC	0.672000												
ERC2	26059	broad.mit.edu	37	3	56207483	56207483	+	Silent	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr3:56207483G>A	uc003dhr.1	-	4	1396	c.1140C>T	c.(1138-1140)ATC>ATT	p.I380I		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	380	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CCTTCATTTCGATGACAGTCT	0.468000												
ANK2	287	broad.mit.edu	37	4	114264209	114264209	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr4:114264209G>A	uc003ibe.3	+	34	4259	c.4159G>A	c.(4159-4161)GGC>AGC	p.G1387S	ANK2_uc003ibd.3_Missense_Mutation_p.G1378S|ANK2_uc003ibf.3_Missense_Mutation_p.G1387S|ANK2_uc011cgc.1_Missense_Mutation_p.G563S|ANK2_uc003ibg.3_Missense_Mutation_p.G382S|ANK2_uc003ibh.3_Missense_Mutation_p.G61S|ANK2_uc011cgb.1_Missense_Mutation_p.G1402S	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1354					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGATTGTTTCGGCAACTTGGT	0.338000												
PCDHA7	56141	broad.mit.edu	37	5	140215213	140215213	+	Silent	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr5:140215213C>T	uc003lhq.2	+	1	1245	c.1245C>T	c.(1243-1245)CGC>CGT	p.R415R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.R415R	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	415	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTGGACCGCGAGAGTGTGT	0.617000												
PCDHGB4	8641	broad.mit.edu	37	5	140769318	140769318	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr5:140769318G>A	uc003lkc.1	+	1	1867	c.1867G>A	c.(1867-1869)GAA>AAA	p.E623K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.E623K	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	623	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCACGGGCGAAGTGCGCAC	0.697000												
GRIA1	2890	broad.mit.edu	37	5	153077664	153077664	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr5:153077664G>A	uc003lva.3	+	9	1560	c.1195G>A	c.(1195-1197)GGC>AGC	p.G399S	GRIA1_uc003luy.3_Missense_Mutation_p.G399S|GRIA1_uc003luz.3_Missense_Mutation_p.G304S|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.G319S|GRIA1_uc011dcx.1_Missense_Mutation_p.G330S|GRIA1_uc011dcy.1_Missense_Mutation_p.G409S|GRIA1_uc011dcz.1_Missense_Mutation_p.G409S|GRIA1_uc010jia.1_Missense_Mutation_p.G379S	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	399	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CCAAGCTGGGGGCGATAATTC	0.478000												
DOCK2	1794	broad.mit.edu	37	5	169435708	169435708	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr5:169435708C>T	uc003maf.2	+	32	3270	c.3190C>T	c.(3190-3192)CGG>TGG	p.R1064W	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.R556W	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1064	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGACATGAGACGGCTAATTGG	0.483000												
ABCC10	89845	broad.mit.edu	37	6	43406375	43406375	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr6:43406375G>A	uc003ouy.1	+	8	2184	c.1969G>A	c.(1969-1971)GTG>ATG	p.V657M	ABCC10_uc003ouz.1_Missense_Mutation_p.V629M|ABCC10_uc010jyo.1_Translation_Start_Site	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	657	ABC transporter 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GCGTGGGCATGTGGCAGTGCG	0.612000												
STYXL1	51657	broad.mit.edu	37	7	75643121	75643121	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr7:75643121T>C	uc003uej.3	-	5	565	c.392A>G	c.(391-393)TAT>TGT	p.Y131C	STYXL1_uc011kgf.1_Intron|STYXL1_uc011kgg.1_5'UTR|STYXL1_uc003ueh.2_Intron|STYXL1_uc003uek.3_Intron|STYXL1_uc003uel.2_Missense_Mutation_p.Y131C|STYXL1_uc003uem.2_Missense_Mutation_p.Y131C|STYXL1_uc010ldg.1_Intron|STYXL1_uc010ldh.1_Missense_Mutation_p.Y131C|STYXL1_uc003uen.1_Missense_Mutation_p.Y131C	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	131	Rhodanese.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						GAAGCGCTCATAGCCCCCTTT	0.582000												
LRRN3	54674	broad.mit.edu	37	7	110764041	110764041	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr7:110764041C>T	uc003vft.3	+	4	2259	c.1213C>T	c.(1213-1215)CAG>TAG	p.Q405*	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Nonsense_Mutation_p.Q405*|LRRN3_uc003vfs.3_Nonsense_Mutation_p.Q405*	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	405	Extracellular (Potential).|LRRCT.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ATTCCAAGGTCAGAATGTTCG	0.448000												
SLC13A1	6561	broad.mit.edu	37	7	122765622	122765622	+	Splice_Site	SNP	C	C	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr7:122765622C>A	uc003vkm.2	-	11	1265	c.1240_splice	c.e11+1	p.V414_splice	SLC13A1_uc010lks.2_Splice_Site_p.V290_splice	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate							integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	TGATACTCAACCAATTTCTCC	0.358000												
BLK	640	broad.mit.edu	37	8	11400775	11400775	+	Silent	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr8:11400775G>A	uc003wty.2	+	2	623	c.42G>A	c.(40-42)CCG>CCA	p.P14P	BLK_uc003wtz.2_Intron	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	14					intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		AGGAAAAGCCGATCAAAGAGA	0.607000												
PXDNL	137902	broad.mit.edu	37	8	52322023	52322023	+	Missense_Mutation	SNP	G	G	A			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr8:52322023G>A	uc003xqu.3	-	17	2262	c.2161C>T	c.(2161-2163)CGG>TGG	p.R721W	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	721					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGGAAACACCGGTTGGAGCAG	0.632000												
RGS20	8601	broad.mit.edu	37	8	54871000	54871000	+	Missense_Mutation	SNP	G	G	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr8:54871000G>T	uc003xrp.2	+	6	1241	c.1149G>T	c.(1147-1149)GAG>GAT	p.E383D	RGS20_uc003xrq.2_Missense_Mutation_p.E268D|RGS20_uc010lye.2_Missense_Mutation_p.E175D|RGS20_uc010lyf.2_Missense_Mutation_p.E147D|RGS20_uc003xrs.2_Missense_Mutation_p.E236D|RGS20_uc003xrt.2_Missense_Mutation_p.E117D	NM_170587	NP_733466	O76081	RGS20_HUMAN	regulator of G-protein signaling 20 isoform a	383					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			CCTTATCGGAGAAATCTATTG	0.343000												
TG	7038	broad.mit.edu	37	8	133925324	133925324	+	Missense_Mutation	SNP	C	C	T	rs140482581	byFrequency	TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr8:133925324C>T	uc003ytw.2	+	20	4233	c.4192C>T	c.(4192-4194)CGC>TGC	p.R1398C	TG_uc010mdw.2_Missense_Mutation_p.R157C	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1398					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCTCCTTGGGCGCTTCACAGA	0.552000												
CER1	9350	broad.mit.edu	37	9	14720143	14720143	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr9:14720143C>T	uc003zlj.2	-	2	794	c.749G>A	c.(748-750)GGA>GAA	p.G250E		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	250					BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		TAGGATGTGTCCATCTTCATG	0.493000												
TRIM32	22954	broad.mit.edu	37	9	119461675	119461675	+	Missense_Mutation	SNP	A	A	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr9:119461675A>T	uc004bjx.2	+	2	1812	c.1654A>T	c.(1654-1656)ATT>TTT	p.I552F	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Missense_Mutation_p.I552F	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	552					fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						TGGCTTTTCCATTGGCTCTGT	0.562000									Bardet-Biedl_syndrome			
CACNA1B	774	broad.mit.edu	37	9	140773594	140773594	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr9:140773594C>T	uc004cog.2	+	2	518	c.373C>T	c.(373-375)CCC>TCC	p.P125S	uc004cof.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	125	I.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GGACAAAACGCCCATGTCCGA	0.612000												
MAGEB1	4112	broad.mit.edu	37	X	30269612	30269612	+	Silent	SNP	G	G	A	rs148758545	byFrequency	TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chrX:30269612G>A	uc004dcc.2	+	4	1322	c.1002G>A	c.(1000-1002)GCG>GCA	p.A334A	MAGEB1_uc004dcd.2_Silent_p.A334A|MAGEB1_uc004dce.2_Silent_p.A334A	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	334											0						CTTTTAGAGCGCGTTCTAGAG	0.507000												
PCDH11X	27328	broad.mit.edu	37	X	91132884	91132884	+	Missense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chrX:91132884C>T	uc004efk.1	+	2	2490	c.1645C>T	c.(1645-1647)CCC>TCC	p.P549S	PCDH11X_uc004efl.1_Missense_Mutation_p.P549S|PCDH11X_uc004efo.1_Missense_Mutation_p.P549S|PCDH11X_uc010nmv.1_Missense_Mutation_p.P549S|PCDH11X_uc004efm.1_Missense_Mutation_p.P549S|PCDH11X_uc004efn.1_Missense_Mutation_p.P549S|PCDH11X_uc004efh.1_Missense_Mutation_p.P549S|PCDH11X_uc004efj.1_Missense_Mutation_p.P549S	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	549	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CGGGGTACCACCCTTAACCAG	0.378000												
ATG4A	115201	broad.mit.edu	37	X	107381208	107381208	+	Missense_Mutation	SNP	T	T	C			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chrX:107381208T>C	uc004enr.2	+	8	845	c.722T>C	c.(721-723)GTT>GCT	p.V241A	ATG4A_uc004ent.2_Intron|ATG4A_uc004ens.2_Missense_Mutation_p.V157A|ATG4A_uc011msl.1_Intron|ATG4A_uc010npi.2_RNA|ATG4A_uc004enu.2_Missense_Mutation_p.V157A	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	241					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						CCTGTCTATGTTGATGCATTC	0.532000												
SLITRK2	84631	broad.mit.edu	37	X	144904988	144904988	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chrX:144904988C>T	uc004fcd.2	+	5	2035	c.1045C>T	c.(1045-1047)CAG>TAG	p.Q349*	SLITRK2_uc010nsp.2_Nonsense_Mutation_p.Q349*|SLITRK2_uc010nso.2_Nonsense_Mutation_p.Q349*|SLITRK2_uc011mwq.1_Nonsense_Mutation_p.Q349*|SLITRK2_uc011mwr.1_Nonsense_Mutation_p.Q349*|SLITRK2_uc011mws.1_Nonsense_Mutation_p.Q349*|SLITRK2_uc004fcg.2_Nonsense_Mutation_p.Q349*|SLITRK2_uc011mwt.1_Nonsense_Mutation_p.Q349*	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	349	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCACCTCTCAGAGCTCAGA	0.498000												
KIAA1109	84162	broad.mit.edu	37	4	123236709	123236720	+	In_Frame_Del	DEL	AATGCTCTGGGC	AATGCTCTGGGC	-			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr4:123236708_123236719TAATGCTCTGGGC>T	uc003ieh.3	+	58	10449_10460	c.10404_10415TAATGCTCTGGGC>T	c.(10402-10416)cttaatgctctgggc>ctTc	p.NALG3469del	KIAA1109_uc003iel.1_In_Frame_Del_p.NALG1404del	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	Homo sapiens KIAA1109 (KIAA1109), mRNA.	3469					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GCAAAAGGCTTAATGCTCTGGGCAATACTCTT	0.415												
NTF3	4908	broad.mit.edu	37	12	5603609	5603610	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr12:5603608_5603609G>GC	uc001qnl.4	+	0	311_312	c.228_229G>GC	c.(226-231)gggcccfs	p.G76fs	NTF3_uc001qnk.4_Frame_Shift_Ins_p.G89fs	NM_002527	NP_002518	P20783	NTF3_HUMAN	Homo sapiens neurotrophin 3 (NTF3), transcript variant 2, mRNA.	76			G -> E (in dbSNP:rs1805149).		signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						AGCGGGGAGGGCCCGCCAAGTC	0.579												
PLA2G1B	5319	broad.mit.edu	37	12	120763700	120763701	+	Frame_Shift_Ins	INS	-	-	CA	rs78096484		TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr12:120763699_120763700C>CCA	uc001tyd.3	-	1	194_195	c.158_159G>TGG	c.(157-159)ttgfs	p.L53fs	PLA2G1B_uc009zwx.3_Frame_Shift_Ins_p.L53fs	NM_000928	NP_000919	P04054	PA21B_HUMAN	Homo sapiens phospholipase A2, group IB (pancreas) (PLA2G1B), mRNA.	53					actin filament organization|activation of MAPK activity|activation of phospholipase A2 activity|arachidonic acid secretion|cellular response to insulin stimulus|glucose transport|interleukin-8 production|leukotriene biosynthetic process|multicellular organismal lipid catabolic process|neutrophil chemotaxis|neutrophil mediated immunity|phosphatidylcholine metabolic process|positive regulation of DNA replication|positive regulation of NF-kappaB transcription factor activity|positive regulation of calcium ion transport into cytosol|positive regulation of immune response|positive regulation of protein secretion|positive regulation of transcription from RNA polymerase II promoter	extracellular space	bile acid binding|calcium ion binding|calcium-dependent phospholipase A2 activity|cell surface binding|receptor binding			endometrium(1)|large_intestine(1)|lung(3)|skin(2)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGAGCCCCCCAAGCCACAGTA	0.614											OREG0022189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
BZRAP1	9256	broad.mit.edu	37	17	56386384	56386385	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr17:56386383_56386384C>CT	uc002ivx.4	-	21	5120_5121	c.4249_4250G>AG	c.(4249-4251)agcfs	p.S1417fs	BZRAP1_uc002ivw.3_5'Flank|BZRAP1_uc010dcs.3_Frame_Shift_Ins_p.S1357fs|BZRAP1_uc010wnt.2_Frame_Shift_Ins_p.S1417fs	NM_004758	NP_004749	O95153	RIMB1_HUMAN	Homo sapiens benzodiazapine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant 1, mRNA.	1417						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGCCTGCGGCTTGGGGGCTTC	0.653												
MYT1	4661	broad.mit.edu	37	20	62839435	62839440	+	In_Frame_Del	DEL	GAGGAA	GAGGAA	-	rs143133195	byFrequency	TCGA-HU-8610-01A-22D-2394-08	TCGA-HU-8610-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1469c2ef-0b9a-4029-baae-b234b857894b	001cfcd7-98cd-427a-9fed-2c6ed7999033	g.chr20:62839434_62839439GGAGGAA>G	uc002yii.3	+	6	1249_1254	c.885_890GGAGGAA>G	c.(883-891)gaggaggaa>gaGa	p.295_297EEE>E	MYT1_uc002yih.3_Intron|MYT1_uc002yij.3_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	Homo sapiens myelin transcription factor 1 (MYT1), mRNA.	295	Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E295K(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					aggaagaggaggaggaagaggaagag	0.583