Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
ABCA4	24	broad.mit.edu	37	1	94546153	94546153	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr1:94546153G>A	uc001dqh.2	-	8	1084	c.980C>T	c.(979-981)CCC>CTC	p.P327L	ABCA4_uc010otn.1_Missense_Mutation_p.P327L	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	327	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		ACCTCCCTCGGGGTAGCCACA	0.532												
CSDE1	7812	broad.mit.edu	37	1	115266562	115266562	+	Silent	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr1:115266562C>T	uc001efk.2	-	16	2281	c.1815G>A	c.(1813-1815)CTG>CTA	p.L605L	CSDE1_uc001efi.2_Silent_p.L651L|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Silent_p.L574L|CSDE1_uc001efm.2_Silent_p.L620L|CSDE1_uc009wgv.2_Silent_p.L605L|CSDE1_uc001efn.2_Silent_p.L574L	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	605					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAACACTCCTCAGGGGGCGAA	0.423												
FLG	2312	broad.mit.edu	37	1	152286012	152286012	+	Missense_Mutation	SNP	G	G	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr1:152286012G>T	uc001ezu.1	-	3	1386	c.1350C>A	c.(1348-1350)CAC>CAA	p.H450Q	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	450	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGACTCTTGGTGGCTCTGCT	0.577									Ichthyosis			
SLAMF6	114836	broad.mit.edu	37	1	160465991	160465991	+	Missense_Mutation	SNP	T	T	C	rs61761948		TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr1:160465991T>C	uc001fwe.1	-	2	302	c.242A>G	c.(241-243)AAA>AGA	p.K81R	SLAMF6_uc001fwd.1_Missense_Mutation_p.K81R|SLAMF6_uc010pjh.1_Missense_Mutation_p.K32R|SLAMF6_uc010pji.1_Intron|SLAMF6_uc010pjj.1_Intron|SLAMF6_uc009wtm.1_Missense_Mutation_p.K32R	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	81	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			CTTTCCCTGTTTCGGATTAGT	0.463												
HMCN1	83872	broad.mit.edu	37	1	186158760	186158760	+	Missense_Mutation	SNP	G	G	A	rs148530862		TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr1:186158760G>A	uc001grq.1	+	107	16887	c.16658G>A	c.(16657-16659)CGG>CAG	p.R5553Q	HMCN1_uc001grs.1_Missense_Mutation_p.R1005Q	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5553					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GATTTAATCCGGCTGGTTGCA	0.468												
KLHL12	59349	broad.mit.edu	37	1	202878254	202878254	+	Splice_Site	SNP	T	T	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr1:202878254T>A	uc001gyo.1	-	6	918	c.718_splice	c.e6-1	p.P240_splice	KLHL12_uc001gym.1_5'UTR|KLHL12_uc001gyn.1_Splice_Site_p.P90_splice|KLHL12_uc010pqc.1_Splice_Site_p.P278_splice|KLHL12_uc009xah.1_Splice_Site_p.P240_splice	NM_021633	NP_067646	Q53G59	KLH12_HUMAN	kelch-like 12						Wnt receptor signaling pathway		protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			GATGAAAGGCTGAAATATAGC	0.438												
DCLRE1C	64421	broad.mit.edu	37	10	14976747	14976747	+	Silent	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:14976747C>T	uc001inn.2	-	7	577	c.492G>A	c.(490-492)TTG>TTA	p.L164L	DCLRE1C_uc010qbx.1_Silent_p.L164L|DCLRE1C_uc001inl.2_Silent_p.L44L|DCLRE1C_uc009xji.2_Silent_p.L49L|DCLRE1C_uc001inm.2_Silent_p.L44L|DCLRE1C_uc001ino.2_Silent_p.L49L|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_Silent_p.L44L|DCLRE1C_uc001inq.2_Silent_p.L44L|DCLRE1C_uc001inr.2_Silent_p.L49L|DCLRE1C_uc009xjj.1_RNA	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	164					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						ACGTAGTATCCAAATATACAC	0.343								Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ				
FAM21A	387680	broad.mit.edu	37	10	51827887	51827887	+	Missense_Mutation	SNP	A	A	G			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:51827887A>G	uc001jjb.2	+	2	108	c.26A>G	c.(25-27)CAG>CGG	p.Q9R	uc001jiz.1_5'Flank|FAM21A_uc001jja.1_5'UTR|FAM21A_uc010qhi.1_Missense_Mutation_p.Q9R|FAM21A_uc010qhj.1_Missense_Mutation_p.Q9R	NM_001005751	NP_001005751	Q641Q2	FA21A_HUMAN	hypothetical protein LOC387680	9					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				ovary(1)	1						ACCCCCGACCAGGAGCTGGCG	0.711												
ASAH2	56624	broad.mit.edu	37	10	52003054	52003054	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:52003054G>A	uc001jjd.2	-	3	418	c.418C>T	c.(418-420)CGT>TGT	p.R140C	ASAH2_uc009xos.2_Missense_Mutation_p.R140C	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	140	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						ATGAAGGCACGACTGTATAGC	0.512												
ANK3	288	broad.mit.edu	37	10	61932869	61932869	+	Missense_Mutation	SNP	C	C	G			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:61932869C>G	uc001jky.2	-	19	2452	c.2260G>C	c.(2260-2262)GCA>CCA	p.A754P	ANK3_uc001jkx.2_5'Flank|ANK3_uc010qih.1_Missense_Mutation_p.A737P|ANK3_uc001jkz.3_Missense_Mutation_p.A748P|ANK3_uc001jlb.1_Missense_Mutation_p.A283P|ANK3_uc001jlc.1_Missense_Mutation_p.A415P	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	754	ANK 21.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTAACTTTTGCAGAATGCTGG	0.343												
PTEN	5728	broad.mit.edu	37	10	89653785	89653785	+	Missense_Mutation	SNP	T	T	G			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:89653785T>G	uc001kfb.2	+	3	1114	c.83T>G	c.(82-84)ATT>AGT	p.I28S		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	28	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(4)|p.Y27fs*1(3)|p.Y27_N212>Y(2)|p.I28M(1)|p.I28fs*17(1)|p.Y29fs*25(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TACTCAGATATTTATCCAAAC	0.294		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)		
IFIT1	3434	broad.mit.edu	37	10	91162119	91162119	+	Silent	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:91162119C>T	uc001kgi.2	+	2	235	c.87C>T	c.(85-87)GAC>GAT	p.D29D	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|IFIT1_uc009xtt.2_Silent_p.D29D|IFIT1_uc001kgj.2_Translation_Start_Site	NM_001548	NP_001539	P09914	IFIT1_HUMAN	interferon-induced protein with	29					cellular response to exogenous dsRNA|intracellular transport of viral proteins in host cell|negative regulation of defense response to virus by host|negative regulation of helicase activity|negative regulation of protein binding|negative regulation of viral genome replication|positive regulation of viral genome replication|response to virus|type I interferon-mediated signaling pathway	cytoplasm	protein binding				0						CCATTGATGACGATGAAATGC	0.383												
LBX1	10660	broad.mit.edu	37	10	102987212	102987212	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:102987212C>T	uc001ksx.2	-	2	806	c.661G>A	c.(661-663)GGT>AGT	p.G221S	uc010qpy.1_5'Flank	NM_006562	NP_006553	P52954	LBX1_HUMAN	ladybird homeobox 1	221	Poly-Gly.				muscle organ development		sequence-specific DNA binding				0		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		CCGCCGCCACCGCCGGCTGTG	0.741												
C10orf82	143379	broad.mit.edu	37	10	118424407	118424407	+	Missense_Mutation	SNP	G	G	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:118424407G>T	uc001lcr.2	-	4	381	c.326C>A	c.(325-327)GCA>GAA	p.A109E	C10orf82_uc001lcs.1_3'UTR	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	109											0				all cancers(201;0.0143)		CAGGTAGCCTGCCCAGCCAGG	0.493												
C10orf120	399814	broad.mit.edu	37	10	124457429	124457429	+	Silent	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr10:124457429G>A	uc001lgn.2	-	3	860	c.828C>T	c.(826-828)ATC>ATT	p.I276I		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	276										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				TTAGGCCTGCGATGGACCGTT	0.398												
OR52A4	390053	broad.mit.edu	37	11	5142176	5142176	+	Silent	SNP	A	A	G			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr11:5142176A>G	uc001lzz.1	-	1	633	c.633T>C	c.(631-633)GTT>GTC	p.V211V		NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAAGCCCACCAACAATAAATG	0.393												
SLC17A6	57084	broad.mit.edu	37	11	22363309	22363309	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr11:22363309G>A	uc001mqk.2	+	2	735	c.322G>A	c.(322-324)GGC>AGC	p.G108S		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	108	Vesicular (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						CCACCGCGGGGGCAAGGTCAT	0.627												
OR8H3	390152	broad.mit.edu	37	11	55890333	55890333	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr11:55890333C>T	uc001nii.1	+	1	485	c.485C>T	c.(484-486)TCC>TTC	p.S162F		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					AATGTGGTTTCCATGAGCAGA	0.438												
HTR3A	3359	broad.mit.edu	37	11	113853876	113853876	+	Missense_Mutation	SNP	G	G	A	rs139646314		TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr11:113853876G>A	uc010rxb.1	+	5	660	c.427G>A	c.(427-429)GTG>ATG	p.V143M	HTR3A_uc010rxa.1_Missense_Mutation_p.V143M|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Missense_Mutation_p.V122M	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	137	Extracellular (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	TATCCCGTACGTGTATATTCG	0.532												
CLEC9A	283420	broad.mit.edu	37	12	10215774	10215774	+	Missense_Mutation	SNP	C	C	T	rs149852205		TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr12:10215774C>T	uc001qxa.2	+	7	1053	c.440C>T	c.(439-441)ACG>ATG	p.T147M		NM_207345	NP_997228	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	147	Extracellular (Potential).|C-type lectin.				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			ovary(1)	1						GAAGGTTCCACGCTGCTACAA	0.348												
ERBB3	2065	broad.mit.edu	37	12	56495354	56495354	+	Missense_Mutation	SNP	C	C	G			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr12:56495354C>G	uc001sjh.2	+	28	3737	c.3544C>G	c.(3544-3546)CTC>GTC	p.L1182V	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Missense_Mutation_p.L539V|ERBB3_uc010sqc.1_Missense_Mutation_p.L1123V|ERBB3_uc009zok.2_Missense_Mutation_p.L447V|ERBB3_uc001sjk.2_Missense_Mutation_p.L423V|ERBB3_uc001sjl.2_Missense_Mutation_p.L302V|PA2G4_uc001sjm.2_5'Flank|PA2G4_uc009zol.2_5'Flank|PA2G4_uc009zom.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	1182	Cytoplasmic (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			TTCAGTGGGTCTCAGTTCTGT	0.517												
LATS2	26524	broad.mit.edu	37	13	21555776	21555776	+	Missense_Mutation	SNP	T	T	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr13:21555776T>C	uc009zzs.2	-	6	2859	c.2494A>G	c.(2494-2496)AGA>GGA	p.R832G	LATS2_uc001unr.3_Missense_Mutation_p.R832G	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	LATS, large tumor suppressor, homolog 2	832	Protein kinase.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(3)|ovary(2)|breast(1)|pancreas(1)	10		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CTGTCCTGTCTGACATGGCTC	0.493												
KIAA1704	55425	broad.mit.edu	37	13	45578502	45578502	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr13:45578502G>A	uc001uzq.2	+	2	254	c.151G>A	c.(151-153)GAA>AAA	p.E51K	KIAA1704_uc010tfo.1_RNA|KIAA1704_uc001uzr.1_Missense_Mutation_p.E51K|KIAA1704_uc001uzs.2_5'UTR|KIAA1704_uc001uzt.2_5'Flank	NM_018559	NP_061029	Q8IXQ4	K1704_HUMAN	hypothetical protein LOC55425	51										pancreas(1)|skin(1)	2		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		AGACAGCGATGAAGACAGTAG	0.388												
CDAN1	146059	broad.mit.edu	37	15	43021535	43021535	+	Silent	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr15:43021535C>T	uc001zql.2	-	18	2550	c.2433G>A	c.(2431-2433)TCG>TCA	p.S811S	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Silent_p.S137S	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	811						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CTGACACCCACGAAGCGAGCA	0.567												
ANPEP	290	broad.mit.edu	37	15	90347484	90347484	+	Missense_Mutation	SNP	C	C	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr15:90347484C>A	uc002bop.3	-	6	1471	c.1179G>T	c.(1177-1179)CAG>CAT	p.Q393H		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	393	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GGGGGTCTACCTGGTGGGCCA	0.642												
EEF2K	29904	broad.mit.edu	37	16	22268610	22268610	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr16:22268610C>T	uc002dki.2	+	8	1290	c.805C>T	c.(805-807)CAG>TAG	p.Q269*	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	269	Alpha-type protein kinase.				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		TTCCGGCCATCAGCTGATAGT	0.562												
WSCD1	23302	broad.mit.edu	37	17	6021341	6021341	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr17:6021341G>A	uc010cli.2	+	8	1587	c.1208G>A	c.(1207-1209)CGA>CAA	p.R403Q	WSCD1_uc002gcn.2_Missense_Mutation_p.R403Q|WSCD1_uc002gco.2_Missense_Mutation_p.R403Q|WSCD1_uc010clj.2_Missense_Mutation_p.R94Q	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	403						integral to membrane	sulfotransferase activity				0						TGGCGGAGCCGACGCACCATC	0.557												
TP53	7157	broad.mit.edu	37	17	7578413	7578413	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr17:7578413C>T	uc002gim.2	-	5	711	c.517G>A	c.(517-519)GTG>ATG	p.V173M	TP53_uc002gig.1_Missense_Mutation_p.V173M|TP53_uc002gih.2_Missense_Mutation_p.V173M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V41M|TP53_uc010cng.1_Missense_Mutation_p.V41M|TP53_uc002gii.1_Missense_Mutation_p.V41M|TP53_uc010cnh.1_Missense_Mutation_p.V173M|TP53_uc010cni.1_Missense_Mutation_p.V173M|TP53_uc002gij.2_Missense_Mutation_p.V173M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.V80M|TP53_uc002gio.2_Missense_Mutation_p.V41M|TP53_uc010vug.1_Missense_Mutation_p.V134M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	173	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|V -> E (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> A (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V173L(54)|p.V173M(40)|p.V173A(8)|p.V173V(8)|p.0?(7)|p.V173G(6)|p.V173fs*1(4)|p.V80L(2)|p.V173fs*59(2)|p.V41L(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V172_R174delVVR(1)|p.V173fs*69(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.V173E(1)|p.E171fs*1(1)|p.V173W(1)|p.V173fs*8(1)|p.H168fs*69(1)|p.V80M(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.V41M(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCCTCACAACCTCCGTC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
NDEL1	81565	broad.mit.edu	37	17	8349043	8349043	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr17:8349043G>A	uc002glj.2	+	3	298	c.101G>A	c.(100-102)CGG>CAG	p.R34Q	NDEL1_uc002gli.2_Missense_Mutation_p.R34Q	NM_030808	NP_110435	Q9GZM8	NDEL1_HUMAN	nudE nuclear distribution gene E homolog (A.	34	Potential.				chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|microtubule|spindle					0						CAGGAAGCTCGGGATGAGCTA	0.423												
ALDH3A2	224	broad.mit.edu	37	17	19555900	19555900	+	Missense_Mutation	SNP	T	T	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr17:19555900T>A	uc002gwb.1	+	3	647	c.426T>A	c.(424-426)AAT>AAA	p.N142K	ALDH3A2_uc002gwa.1_Missense_Mutation_p.N142K|ALDH3A2_uc010cqr.1_5'UTR|ALDH3A2_uc002gwc.1_Missense_Mutation_p.N142K	NM_000382	NP_000373	P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3A2 isoform 2	142	Cytoplasmic.				cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(2)	2	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	TGAGTGAAAATACAGCCAAGA	0.333												
KPNB1	3837	broad.mit.edu	37	17	45757454	45757454	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr17:45757454G>A	uc002ilt.1	+	20	2758	c.2422G>A	c.(2422-2424)GAG>AAG	p.E808K	KPNB1_uc010wkw.1_Missense_Mutation_p.E663K|KPNB1_uc010wkx.1_Missense_Mutation_p.E592K	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	808					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TGCTGGAGATGAGGATCACAC	0.393												
MUC16	94025	broad.mit.edu	37	19	9018164	9018164	+	Silent	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr19:9018164G>A	uc002mkp.2	-	25	37978	c.37774C>T	c.(37774-37776)CTG>TTG	p.L12592L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12594	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAGAGTACAGAAGGCCAACA	0.537												
PDE4A	5141	broad.mit.edu	37	19	10568647	10568647	+	Missense_Mutation	SNP	C	C	G			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr19:10568647C>G	uc002moj.2	+	8	1078	c.970C>G	c.(970-972)CCC>GCC	p.P324A	PDE4A_uc002mok.2_Missense_Mutation_p.P298A|PDE4A_uc002mol.2_Missense_Mutation_p.P263A|PDE4A_uc002mom.2_Missense_Mutation_p.P85A|PDE4A_uc002mon.2_Intron|PDE4A_uc002moo.2_5'Flank	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	324					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	GCCGCCCCCGCCCCCTGTACC	0.522												
PRKCSH	5589	broad.mit.edu	37	19	11556203	11556203	+	Splice_Site	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr19:11556203G>A	uc002mrt.2	+	8	935	c.599_splice	c.e8-1	p.E200_splice	PRKCSH_uc002mru.2_Splice_Site_p.E200_splice|PRKCSH_uc010xlz.1_Splice_Site_p.E200_splice|PRKCSH_uc010dya.2_Intron|PRKCSH_uc002mrv.1_Splice_Site_p.E200_splice|PRKCSH_uc010dyb.2_Splice_Site_p.E200_splice	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1						innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						CTTCTTTACAGAGCAGCTGGC	0.572												
CPAMD8	27151	broad.mit.edu	37	19	17122279	17122279	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr19:17122279C>T	uc002nfb.2	-	5	654	c.622G>A	c.(622-624)GAG>AAG	p.E208K		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	161						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CTCACCTTCTCGTTGACAGGC	0.572												
KIRREL2	84063	broad.mit.edu	37	19	36349318	36349318	+	Missense_Mutation	SNP	C	C	T	rs143964977		TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr19:36349318C>T	uc002ocb.3	+	3	432	c.220C>T	c.(220-222)CGG>TGG	p.R74W	KIRREL2_uc002obz.3_Missense_Mutation_p.R74W|KIRREL2_uc002oca.3_Missense_Mutation_p.R24W|KIRREL2_uc002occ.3_Missense_Mutation_p.R21W|KIRREL2_uc002ocd.3_Missense_Mutation_p.R71W	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	74	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGGGTGGTCCCGGTACTGGAT	0.552												
APLP1	333	broad.mit.edu	37	19	36370317	36370317	+	Missense_Mutation	SNP	T	T	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr19:36370317T>C	uc002oce.2	+	17	2065	c.1927T>C	c.(1927-1929)TAC>CAC	p.Y643H	APLP1_uc010xsz.1_Missense_Mutation_p.Y604H|APLP1_uc002ocf.2_Missense_Mutation_p.Y644H|APLP1_uc002ocg.2_Missense_Mutation_p.Y547H|APLP1_uc010xta.1_Missense_Mutation_p.Y637H	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	643	Clathrin-binding (Potential).|NPXY motif; contains endocytosis signal.|Cytoplasmic (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAACCCCACTTACCGCTTCCT	0.657												
SLC6A16	28968	broad.mit.edu	37	19	49797748	49797748	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr19:49797748G>A	uc002pmz.2	-	8	1526	c.1292C>T	c.(1291-1293)CCT>CTT	p.P431L	SLC6A16_uc002pna.2_Missense_Mutation_p.P431L	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	431	Extracellular (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		CAGGTTGACAGGGGGCTTGGC	0.502												
TEAD2	8463	broad.mit.edu	37	19	49850456	49850456	+	Silent	SNP	G	G	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr19:49850456G>C	uc002pnj.2	-	9	991	c.900C>G	c.(898-900)GTC>GTG	p.V300V	TEAD2_uc002png.2_Silent_p.V303V|TEAD2_uc002pnh.2_Silent_p.V304V|TEAD2_uc002pni.2_Silent_p.V303V|TEAD2_uc010yao.1_Silent_p.V172V|TEAD2_uc010emw.2_Silent_p.V303V	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	300	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		CCCAGAACTTGACCAGGAAGA	0.547												
KIAA1310	55683	broad.mit.edu	37	2	97271204	97271204	+	Missense_Mutation	SNP	G	G	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr2:97271204G>T	uc002swn.3	-	15	1932	c.1786C>A	c.(1786-1788)CTT>ATT	p.L596I	KIAA1310_uc002swh.3_Missense_Mutation_p.L484I|KIAA1310_uc002swi.3_Missense_Mutation_p.L523I|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Missense_Mutation_p.L509I|KIAA1310_uc010fhz.2_Missense_Mutation_p.L416I|KIAA1310_uc002swl.3_Missense_Mutation_p.L497I|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Missense_Mutation_p.L390I|KIAA1310_uc002swo.2_5'UTR|KIAA1310_uc002swp.1_Missense_Mutation_p.L497I	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	622											0						TGAACCCTAAGATCCTCTTTC	0.502												
AFF3	3899	broad.mit.edu	37	2	100181979	100181979	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr2:100181979G>A	uc002tag.2	-	19	3325	c.3089C>T	c.(3088-3090)ACG>ATG	p.T1030M	AFF3_uc002taf.2_Missense_Mutation_p.T1055M	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	1030				T -> YL (in Ref. 1; AAA98763).	multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TGAATACATCGTATAAGGAGA	0.448												
SDPR	8436	broad.mit.edu	37	2	192700704	192700704	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr2:192700704C>T	uc002utb.2	-	2	1553	c.1223G>A	c.(1222-1224)CGC>CAC	p.R408H		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	408						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CCCATCGGAGCGCTCCGCCTC	0.622												
SLC39A10	57181	broad.mit.edu	37	2	196548511	196548511	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr2:196548511C>T	uc002utg.3	+	3	1311	c.1097C>T	c.(1096-1098)GCA>GTA	p.A366V	SLC39A10_uc002uth.3_Missense_Mutation_p.A366V|SLC39A10_uc010zgp.1_5'UTR	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	366					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			CTTTGCCCTGCATTGTTATAT	0.358												
UMODL1	89766	broad.mit.edu	37	21	43531059	43531059	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr21:43531059C>T	uc002zaf.1	+	11	1727	c.1727C>T	c.(1726-1728)ACG>ATG	p.T576M	UMODL1_uc002zad.1_Missense_Mutation_p.T504M|UMODL1_uc002zae.1_Missense_Mutation_p.T504M|UMODL1_uc002zag.1_Missense_Mutation_p.T576M|C21orf128_uc002zak.2_5'Flank	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	576	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						GGTCTTGGCACGGGAACAGCA	0.657												
LGALS1	3956	broad.mit.edu	37	22	38074508	38074508	+	Silent	SNP	C	C	T	rs111593545		TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr22:38074508C>T	uc003atn.2	+	3	205	c.108C>T	c.(106-108)GGC>GGT	p.G36G		NM_002305	NP_002296	P09382	LEG1_HUMAN	galectin-1	36	Galectin.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of apoptosis	cytoplasm|extracellular space|proteinaceous extracellular matrix	galactoside binding|signal transducer activity				0	Melanoma(58;0.0574)					TGAACCTGGGCAAAGACAGCA	0.622												
SGEF	26084	broad.mit.edu	37	3	153973256	153973256	+	Silent	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr3:153973256C>T	uc011bog.1	+	15	2821	c.2610C>T	c.(2608-2610)AAC>AAT	p.N870N	SGEF_uc011boh.1_3'UTR|SGEF_uc011boi.1_Silent_p.N138N	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	870					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TGGAGACCAACGTGTAGTCTC	0.453												
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)		
ADD1	118	broad.mit.edu	37	4	2895781	2895781	+	Silent	SNP	T	T	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr4:2895781T>C	uc003gfr.2	+	5	740	c.552T>C	c.(550-552)CCT>CCC	p.P184P	ADD1_uc003gfn.2_Intron|ADD1_uc010ico.1_Silent_p.P184P|ADD1_uc003gfo.2_Silent_p.P184P|ADD1_uc003gfp.2_Silent_p.P184P|ADD1_uc003gfq.2_Silent_p.P184P|ADD1_uc003gfs.2_Silent_p.P184P|ADD1_uc003gft.3_Silent_p.P184P|ADD1_uc003gfu.2_5'UTR	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	184					actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TCATTGTCCCTTTTGGGCTTC	0.428												
RPL9	6133	broad.mit.edu	37	4	39458038	39458038	+	Missense_Mutation	SNP	G	G	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr4:39458038G>C	uc003gub.2	-	4	527	c.379C>G	c.(379-381)CGG>GGG	p.R127G	RPL9_uc003guc.2_Missense_Mutation_p.R127G|RPL9_uc011byk.1_RNA|RPL9_uc011byl.1_Missense_Mutation_p.R127G|LIAS_uc003gue.3_5'Flank|LIAS_uc011bym.1_5'Flank|LIAS_uc003guf.2_5'Flank|LIAS_uc003gug.2_5'Flank|LIAS_uc003guh.2_5'Flank	NM_001024921	NP_001020092	P32969	RL9_HUMAN	ribosomal protein L9	127					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|nucleolus|ribosome	rRNA binding|structural constituent of ribosome			skin(1)	1						GGTCTCATCCGAACCCTGCGG	0.408												
USP53	54532	broad.mit.edu	37	4	120177442	120177442	+	Missense_Mutation	SNP	C	C	G			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr4:120177442C>G	uc003ics.3	+	7	1480	c.414C>G	c.(412-414)AGC>AGG	p.S138R	USP53_uc003icr.3_Missense_Mutation_p.S138R|USP53_uc003icu.3_5'UTR	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	138					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						TAGTGCCAAGCAGAGATGCAG	0.343												
MTNR1A	4543	broad.mit.edu	37	4	187455407	187455407	+	Silent	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr4:187455407G>A	uc003izd.1	-	2	507	c.489C>T	c.(487-489)CTC>CTT	p.L163L		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	163	Helical; Name=4; (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TCCCTGCACGGAGGTTGGGCA	0.602												
HIST1H3H	8357	broad.mit.edu	37	6	27777970	27777970	+	Missense_Mutation	SNP	A	A	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr6:27777970A>C	uc003njm.2	+	1	129	c.119A>C	c.(118-120)CAT>CCT	p.H40P	HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h	40					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						AAGAAGCCCCATCGCTATCGG	0.647												
C6orf142	90523	broad.mit.edu	37	6	54034364	54034364	+	Silent	SNP	C	C	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr6:54034364C>A	uc003pcg.3	+	8	1046	c.933C>A	c.(931-933)ACC>ACA	p.T311T	C6orf142_uc003pcf.2_Silent_p.T835T|C6orf142_uc003pch.3_Silent_p.T155T|C6orf142_uc011dxa.1_Silent_p.T846T	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	311						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					GTCGAGAAACCAAATATGTAA	0.299												
PHF3	23469	broad.mit.edu	37	6	64410303	64410303	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr6:64410303G>A	uc003pep.1	+	8	3072	c.3046G>A	c.(3046-3048)GAA>AAA	p.E1016K	PHF3_uc010kah.1_Missense_Mutation_p.E830K|PHF3_uc003pen.2_Missense_Mutation_p.E928K|PHF3_uc011dxs.1_Missense_Mutation_p.E285K	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	1016	TFIIS central.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AATGAGTCCAGAAGAACTAGC	0.323												
ARMC2	84071	broad.mit.edu	37	6	109274511	109274511	+	Silent	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr6:109274511G>A	uc003pss.3	+	13	2046	c.1872G>A	c.(1870-1872)CTG>CTA	p.L624L	ARMC2_uc011eao.1_Silent_p.L459L	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	624	ARM 9.						binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		GCCCGGTGCTGGCCGCCAACC	0.667												
AMD1	262	broad.mit.edu	37	6	111214017	111214017	+	Missense_Mutation	SNP	G	G	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr6:111214017G>T	uc003puk.1	+	7	1017	c.695G>T	c.(694-696)GGA>GTA	p.G232V	AMD1_uc011eay.1_Missense_Mutation_p.G163V|AMD1_uc011eaz.1_Missense_Mutation_p.G203V|AMD1_uc011eba.1_Missense_Mutation_p.G112V|AMD1_uc003pul.1_Missense_Mutation_p.G84V	NM_001634	NP_001625	P17707	DCAM_HUMAN	adenosylmethionine decarboxylase 1 isoform 1	232					spermidine biosynthetic process|spermine biosynthetic process	cytosol	adenosylmethionine decarboxylase activity			upper_aerodigestive_tract(1)	1		all_cancers(87;3.83e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.0522)|Epithelial(106;0.111)|all cancers(137;0.143)	S-Adenosylmethionine(DB00118)	TCGATGAATGGAATGAAATCG	0.393												
GTF2IRD2	84163	broad.mit.edu	37	7	74212378	74212378	+	Silent	SNP	T	T	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr7:74212378T>C	uc003ubd.1	-	16	1657	c.1473A>G	c.(1471-1473)AAA>AAG	p.K491K	GTF2IRD2_uc010lbt.1_Silent_p.K38K	NM_173537	NP_775808	Q86UP8	GTD2A_HUMAN	GTF2I repeat domain containing 2	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						tcctgagcccttttttcagct	0												
NCAPG2	54892	broad.mit.edu	37	7	158476040	158476040	+	Silent	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr7:158476040G>A	uc003wnv.1	-	9	1021	c.876C>T	c.(874-876)CAC>CAT	p.H292H	NCAPG2_uc010lqu.1_Silent_p.H84H|NCAPG2_uc003wnw.1_RNA|NCAPG2_uc003wnx.1_Silent_p.H292H|NCAPG2_uc011kwe.1_Silent_p.H292H	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	292					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		GGTGTATCCCGTGGAACATGA	0.428												
C8orf80	389643	broad.mit.edu	37	8	27884560	27884560	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr8:27884560C>T	uc003xgm.3	-	18	2307	c.2164G>A	c.(2164-2166)GTG>ATG	p.V722M		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	722						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		ACCTTCTCCACGATTCCAGTC	0.532												
PRKDC	5591	broad.mit.edu	37	8	48740855	48740855	+	Silent	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr8:48740855C>T	uc003xqi.2	-	63	8508	c.8451G>A	c.(8449-8451)TTG>TTA	p.L2817L	PRKDC_uc003xqj.2_Silent_p.L2817L|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	2817	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCATCTCTTTCAAAATTCCAG	0.323								NHEJ				
COL14A1	7373	broad.mit.edu	37	8	121256220	121256220	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr8:121256220G>A	uc003yox.2	+	20	2717	c.2452G>A	c.(2452-2454)GTC>ATC	p.V818I	COL14A1_uc003yoy.2_Missense_Mutation_p.V496I	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	818	Fibronectin type-III 6.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGCGAAGGCGTCAGCGTCTC	0.493												
BAI1	575	broad.mit.edu	37	8	143623631	143623631	+	Missense_Mutation	SNP	G	G	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr8:143623631G>C	uc003ywm.2	+	27	4219	c.4036G>C	c.(4036-4038)GTG>CTG	p.V1346L		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1346	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CACGAGCTACGTGATCCTGCC	0.642												
ERMP1	79956	broad.mit.edu	37	9	5810125	5810125	+	Missense_Mutation	SNP	A	A	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr9:5810125A>C	uc003zjm.1	-	8	1488	c.1434T>G	c.(1432-1434)ATT>ATG	p.I478M	ERMP1_uc011lme.1_RNA|ERMP1_uc010mhs.1_Missense_Mutation_p.I92M	NM_024896	NP_079172	Q7Z2K6	ERMP1_HUMAN	aminopeptidase Fxna	478	Helical; (Potential).				proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		GAGACTGTCCAATAAGAGAGA	0.403												
DENND1A	57706	broad.mit.edu	37	9	126202698	126202698	+	Missense_Mutation	SNP	C	C	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr9:126202698C>T	uc004bnz.1	-	19	1662	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K	DENND1A_uc011lzl.1_Missense_Mutation_p.E252K|DENND1A_uc004bny.1_Missense_Mutation_p.E216K|DENND1A_uc011lzm.1_Missense_Mutation_p.E445K|DENND1A_uc004boa.1_Missense_Mutation_p.E477K|DENND1A_uc004bob.1_Missense_Mutation_p.E447K|DENND1A_uc004boc.2_Missense_Mutation_p.E445K|DENND1A_uc010mwh.1_5'UTR	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	477						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						TCCTTGGCCTCCACCAGTGGG	0.577												
SAGE1	55511	broad.mit.edu	37	X	134986673	134986673	+	Silent	SNP	A	A	T			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chrX:134986673A>T	uc004ezh.2	+	4	425	c.258A>T	c.(256-258)ATA>ATT	p.I86I	SAGE1_uc010nry.1_Intron|SAGE1_uc011mvv.1_Silent_p.I86I	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	86										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAGAGAGGATAAATAACGGCC	0.448												
MAGEC1	9947	broad.mit.edu	37	X	140994453	140994453	+	Missense_Mutation	SNP	G	G	C			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chrX:140994453G>C	uc004fbt.2	+	4	1549	c.1263G>C	c.(1261-1263)TTG>TTC	p.L421F	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	421							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTACTTTATTGAGTATTTTAC	0.463										HNSCC(15;0.026)		
L1CAM	3897	broad.mit.edu	37	X	153134082	153134082	+	Missense_Mutation	SNP	G	G	A			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chrX:153134082G>A	uc004fjb.2	-	12	1588	c.1480C>T	c.(1480-1482)CGC>TGC	p.R494C	L1CAM_uc004fjc.2_Missense_Mutation_p.R494C|L1CAM_uc010nuo.2_Missense_Mutation_p.R489C|L1CAM_uc004fjd.1_Missense_Mutation_p.R308C	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	494	Extracellular (Potential).|Ig-like C2-type 5.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGAAGTAGCGTCCGGTGTCA	0.557												
DNAJC6	9829	broad.mit.edu	37	1	65871724	65871724	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr1:65871724delA	uc001dcd.1	+	16	2392	c.2228delA	c.(2227-2229)CACfs	p.H743fs	DNAJC6_uc010opc.1_Frame_Shift_Del_p.H730fs|DNAJC6_uc001dce.1_Frame_Shift_Del_p.H800fs	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	743	Pro-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						AGCATGCCCCACTCCTCTCCC	0.602												
FAM86C	55199	broad.mit.edu	37	11	71498623	71498624	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr11:71498623_71498624delAG	uc001oqv.3	+	1	67_68	c.41_42delAG	c.(40-42)CAGfs	p.Q14fs	FAM86C_uc009ysr.2_Frame_Shift_Del_p.Q14fs|FAM86C_uc001oqw.3_Frame_Shift_Del_p.Q14fs|FAM86C_uc009yss.2_RNA|FAM86C_uc010rqq.1_RNA	NM_018172	NP_060642	Q9NVL1	FA86C_HUMAN	hypothetical protein LOC55199 isoform 1	14											0						CTCTTGCTGCAGAGTTTCAAGC	0.644												
KIF26A	26153	broad.mit.edu	37	14	104642071	104642071	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr14:104642071delG	uc001yos.3	+	12	2946	c.2946delG	c.(2944-2946)GTGfs	p.V982fs		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	982					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CCCCTCCCGTGGGCATGAGTG	0.716												
APC	324	broad.mit.edu	37	5	112175944	112175945	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr5:112175944_112175945delAG	uc010jby.2	+	16	5033_5034	c.4653_4654delAG	c.(4651-4656)AAAGAGfs	p.K1551fs	APC_uc011cvt.1_Frame_Shift_Del_p.K1533fs|APC_uc003kpz.3_Frame_Shift_Del_p.K1551fs|APC_uc003kpy.3_Frame_Shift_Del_p.K1551fs|APC_uc010jbz.2_Frame_Shift_Del_p.K1268fs|APC_uc010jca.2_Frame_Shift_Del_p.K851fs	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1551_1552	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1552*(8)|p.K1192fs*3(1)|p.?(1)|p.K1551*(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ACCAAGAGAAAGAGGCAGAAAA	0.342		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)		
PTK7	5754	broad.mit.edu	37	6	43098042	43098063	+	Frame_Shift_Del	DEL	AGCGGAACCTGACGCTCCGGCC	AGCGGAACCTGACGCTCCGGCC	-	rs149112329	by1000genomes	TCGA-FP-7735-01A-11D-2053-08	TCGA-FP-7735-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fe717798-d698-49c2-bbc9-e0c5679505c1	2610c0da-b6d7-4109-9949-6a1023488172	g.chr6:43098041_43098062GAGCGGAACCTGACGCTCCGGCC>G	uc011dve.1	+	3	610_631	c.568_589GAGCGGAACCTGACGCTCCGGCC>G	c.(568-591)gagcggaacctgacgctccggccafs	p.E190fs	PTK7_uc003oub.1_Frame_Shift_Del_p.E182fs|PTK7_uc003ouc.1_Frame_Shift_Del_p.E182fs|PTK7_uc003oud.1_Frame_Shift_Del_p.E182fs|PTK7_uc003oue.1_Frame_Shift_Del_p.E182fs|PTK7_uc003ouf.1_Non-coding_Transcript|PTK7_uc003oug.1_Intron|PTK7_uc010jyj.1_5'Flank|PTK7_uc003oua.3_Frame_Shift_Del_p.E182fs	NM_002821	NP_002812	Q13308	PTK7_HUMAN	Homo sapiens PTK7 protein tyrosine kinase 7 (PTK7), transcript variant PTK7-1, mRNA.	182	Ig-like C2-type 2.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.R188R(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CAGCAGCAAGGAGCGGAACCTGACGCTCCGGCCAGCTGGTCC	0.595