Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
ATAD3C	219293	broad.mit.edu	37	1	1403804	1403804	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:1403804C>T	uc001aft.2	+	12	2125	c.1130C>T	c.(1129-1131)GCC>GTC	p.A377V		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	377							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CTGACCGAGGCCATGATGGAC	0.657000												
CHD5	26038	broad.mit.edu	37	1	6184073	6184073	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:6184073G>A	uc001amb.1	-	31	4734	c.4634C>T	c.(4633-4635)TCG>TTG	p.S1545L	CHD5_uc001alz.1_Missense_Mutation_p.S402L|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1545					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GTTGGGGTCCGAGGAGATCAC	0.667000												
CLCNKB	1188	broad.mit.edu	37	1	16374443	16374443	+	Silent	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:16374443C>T	uc001axw.3	+	5	482	c.402C>T	c.(400-402)GTC>GTT	p.V134V	FAM131C_uc010obz.1_Intron|CLCNKB_uc001axx.3_Silent_p.V134V|CLCNKB_uc001axy.3_5'Flank	NM_000085	NP_000076	P51801	CLCKB_HUMAN	chloride channel Kb isoform 1	134					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			skin(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		CGGGTGTGGTCTTGGAGGACT	0.577000												
EPHA8	2046	broad.mit.edu	37	1	22913046	22913046	+	Silent	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:22913046C>T	uc001bfx.1	+	4	1022	c.897C>T	c.(895-897)TCC>TCT	p.S299S	EPHA8_uc001bfw.2_Silent_p.S299S	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	299	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ACAGCCACTCCGCAGCTCCAG	0.667000												
ZMYND12	84217	broad.mit.edu	37	1	42921644	42921644	+	Missense_Mutation	SNP	C	C	G			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:42921644C>G	uc001chj.2	-	1	295	c.25G>C	c.(25-27)GTC>CTC	p.V9L	ZMYND12_uc010ojt.1_5'UTR|PPCS_uc001chk.2_5'Flank|PPCS_uc001chl.2_5'Flank	NM_032257	NP_115633	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12 isoform 1	9						intracellular	zinc ion binding			ovary(1)	1	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCCTTGGGGACTGCCAGTGGG	0.612000												
GPATCH4	54865	broad.mit.edu	37	1	156566248	156566248	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:156566248C>T	uc001fpm.2	-	6	410	c.371G>A	c.(370-372)GGA>GAA	p.G124E	APOA1BP_uc010php.1_Intron|GPATCH4_uc001fpl.2_Missense_Mutation_p.G119E	NM_015590	NP_056405	Q5T3I0	GPTC4_HUMAN	G patch domain containing 4 isoform 1	119						intracellular	nucleic acid binding			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGCTTCTCTCCACCTGAAGT	0.502000												
OR6K2	81448	broad.mit.edu	37	1	158670349	158670349	+	Missense_Mutation	SNP	G	G	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:158670349G>T	uc001fsu.1	-	1	94	c.94C>A	c.(94-96)CTC>ATC	p.L32I		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TAGATGAAGAGCAGTGGAACA	0.453000												
MNDA	4332	broad.mit.edu	37	1	158819008	158819008	+	Missense_Mutation	SNP	G	G	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:158819008G>T	uc001fsz.1	+	7	1405	c.1205G>T	c.(1204-1206)GGA>GTA	p.G402V		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	402					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					AACAAGGAAGGACCAATGAAT	0.318000												
DDR2	4921	broad.mit.edu	37	1	162724593	162724593	+	Missense_Mutation	SNP	A	A	G			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr1:162724593A>G	uc001gcf.2	+	6	830	c.365A>G	c.(364-366)TAC>TGC	p.Y122C	DDR2_uc001gcg.2_Missense_Mutation_p.Y122C	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	122	Extracellular (Potential).|F5/8 type C.				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			AAGATCAATTACAGTCGGGAT	0.522000												
ZNF438	220929	broad.mit.edu	37	10	31134426	31134426	+	Missense_Mutation	SNP	G	G	C	rs146555674	by1000genomes	TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr10:31134426G>C	uc010qdz.1	-	8	2386	c.1951C>G	c.(1951-1953)CGT>GGT	p.R651G	ZNF438_uc001ivn.2_Missense_Mutation_p.R602G|ZNF438_uc010qdy.1_Missense_Mutation_p.R641G|ZNF438_uc001ivo.3_Missense_Mutation_p.R215G|ZNF438_uc009xlg.2_Missense_Mutation_p.R651G|ZNF438_uc001ivp.3_Missense_Mutation_p.R641G|ZNF438_uc010qea.1_Missense_Mutation_p.R651G|ZNF438_uc010qeb.1_Missense_Mutation_p.R651G	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	651					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				ATCTGACAACGACCACATTTG	0.408000												
ACTA2	59	broad.mit.edu	37	10	90699289	90699289	+	Silent	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr10:90699289C>T	uc001kfp.2	-	7	899	c.783G>A	c.(781-783)GAG>GAA	p.E261E	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Silent_p.E216E|ACTA2_uc001kfq.2_Silent_p.E261E|uc001kfo.1_RNA	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	261					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		GGAACAGGGTCTCTGGGCAGC	0.532000												
NLRP10	338322	broad.mit.edu	37	11	7981973	7981973	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:7981973C>T	uc001mfv.1	-	2	1203	c.1186G>A	c.(1186-1188)GAT>AAT	p.D396N		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	396	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCATCATCATCGGGCGGCAGA	0.557000												
KCNJ11	3767	broad.mit.edu	37	11	17409232	17409232	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:17409232C>T	uc001mna.2	-	1	975	c.407G>A	c.(406-408)CGC>CAC	p.R136H	KCNJ11_uc001mnb.3_Missense_Mutation_p.R49H	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	136						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		AGTCACCATGCGCCCCCCAAA	0.562000												
DGKZ	8525	broad.mit.edu	37	11	46400600	46400600	+	Silent	SNP	G	G	A	rs142962841		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:46400600G>A	uc001ncn.1	+	29	3167	c.3042G>A	c.(3040-3042)ACG>ACA	p.T1014T	DGKZ_uc001nch.1_Silent_p.T842T|DGKZ_uc010rgq.1_3'UTR|DGKZ_uc001ncj.1_Silent_p.T792T|DGKZ_uc010rgr.1_Silent_p.T791T|DGKZ_uc001nck.1_Silent_p.T604T|DGKZ_uc001ncl.2_Silent_p.T826T|DGKZ_uc001ncm.2_Silent_p.T825T|DGKZ_uc009yky.1_Silent_p.T826T|DGKZ_uc010rgs.1_Silent_p.T803T|MDK_uc009ykz.1_5'Flank|MDK_uc001nco.2_5'Flank|MDK_uc001ncp.2_5'Flank|MDK_uc009yla.2_5'Flank|MDK_uc009ylb.2_5'Flank|MDK_uc001ncq.2_5'Flank|MDK_uc001ncr.2_5'Flank|MDK_uc001ncs.2_5'Flank	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	1014	ANK 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		AGAGTCGCACGCTCCTGCACC	0.692000												
ARFGAP2	84364	broad.mit.edu	37	11	47188381	47188381	+	Missense_Mutation	SNP	G	G	A	rs139591977		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:47188381G>A	uc001ndt.2	-	13	1277	c.1262C>T	c.(1261-1263)GCG>GTG	p.A421V	ARFGAP2_uc010rha.1_Missense_Mutation_p.A152V|ARFGAP2_uc010rhb.1_Missense_Mutation_p.A393V|ARFGAP2_uc001ndu.2_Missense_Mutation_p.A285V|ARFGAP2_uc010rhc.1_Missense_Mutation_p.A152V	NM_032389	NP_115765	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating	421	Required for interaction with coatomer.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			ovary(1)	1						TTTCTGACGCGCCTCACTAGA	0.567000												
MADD	8567	broad.mit.edu	37	11	47296188	47296188	+	Missense_Mutation	SNP	T	T	G			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:47296188T>G	uc001ner.1	+	3	328	c.137T>G	c.(136-138)TTT>TGT	p.F46C	MADD_uc001neq.2_Missense_Mutation_p.F46C|MADD_uc001nev.1_Missense_Mutation_p.F46C|MADD_uc001nes.1_Missense_Mutation_p.F46C|MADD_uc001net.1_Missense_Mutation_p.F46C|MADD_uc009yln.1_Missense_Mutation_p.F46C|MADD_uc001neu.1_Missense_Mutation_p.F46C|MADD_uc001nex.2_Missense_Mutation_p.F46C|MADD_uc001nez.2_Missense_Mutation_p.F46C|MADD_uc001new.2_Missense_Mutation_p.F46C	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	46	UDENN.				activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CACACTGAGTTTCCCCTGCCC	0.567000												
FNBP4	23360	broad.mit.edu	37	11	47765704	47765704	+	Silent	SNP	T	T	G			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:47765704T>G	uc009ylv.2	-	8	1410	c.1257A>C	c.(1255-1257)CGA>CGC	p.R419R	FNBP4_uc001ngj.2_Silent_p.R326R|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	419										ovary(1)	1						CCTCCAAGGCTCGCAACTCTG	0.388000												
SYVN1	84447	broad.mit.edu	37	11	64897313	64897313	+	Missense_Mutation	SNP	G	G	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:64897313G>T	uc001odb.2	-	14	1577	c.1483C>A	c.(1483-1485)CAT>AAT	p.H495N	SYVN1_uc001odc.2_Missense_Mutation_p.H494N|SYVN1_uc009yqc.2_Missense_Mutation_p.H443N	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b	495	Cytoplasmic (Potential).				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						TGCCGCTCATGGCCCTCCAGA	0.652000												
FAT3	120114	broad.mit.edu	37	11	92577863	92577863	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:92577863C>T	uc001pdj.3	+	18	11347	c.11330C>T	c.(11329-11331)CCG>CTG	p.P3777L	FAT3_uc001pdi.3_Missense_Mutation_p.P217L	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3777	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTTGTGTGTCCGCGTTTCTAC	0.517000										TCGA Ovarian(4;0.039)		
CCDC84	338657	broad.mit.edu	37	11	118886110	118886110	+	Missense_Mutation	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:118886110T>C	uc001pul.2	+	10	955	c.899T>C	c.(898-900)TTT>TCT	p.F300S	CCDC84_uc010ryk.1_RNA|CCDC84_uc010ryl.1_RNA|CCDC84_uc010rym.1_RNA	NM_198489	NP_940891	Q86UT8	CCD84_HUMAN	coiled-coil domain containing 84	300										ovary(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		CTGCCCTCTTTTGGCCGCGTC	0.542000												
NTM	50863	broad.mit.edu	37	11	131781508	131781508	+	Missense_Mutation	SNP	G	G	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:131781508G>C	uc001qgp.2	+	1	797	c.133G>C	c.(133-135)GTG>CTG	p.V45L	NTM_uc001qgm.2_Missense_Mutation_p.V45L|NTM_uc010sch.1_Missense_Mutation_p.V36L|NTM_uc010sci.1_Missense_Mutation_p.V45L|NTM_uc010scj.1_Missense_Mutation_p.V4L|NTM_uc001qgo.2_Missense_Mutation_p.V45L|NTM_uc001qgq.2_Missense_Mutation_p.V45L	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	45	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						TATGGACAACGTGACGGTCCG	0.617000											OREG0021537	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
GLB1L2	89944	broad.mit.edu	37	11	134238552	134238552	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr11:134238552G>A	uc001qhp.2	+	10	1092	c.904G>A	c.(904-906)GTG>ATG	p.V302M	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	302					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		TTTGAAAACCGTGTCTGCCAT	0.532000												
A2ML1	144568	broad.mit.edu	37	12	9001452	9001452	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr12:9001452G>A	uc001quz.3	+	16	2068	c.1970G>A	c.(1969-1971)CGT>CAT	p.R657H	A2ML1_uc001qva.1_Missense_Mutation_p.R237H|A2ML1_uc010sgm.1_Missense_Mutation_p.R157H	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	501						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						TCGAGCCAGCGTTCCATTATC	0.522000												
HOXC12	3228	broad.mit.edu	37	12	54348852	54348852	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr12:54348852C>T	uc010soq.1	+	1	139	c.139C>T	c.(139-141)CGC>TGC	p.R47C		NM_173860	NP_776272	P31275	HXC12_HUMAN	homeobox C12	47					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						CTACCCACGCCGCGACAACGT	0.672000												
CHST11	50515	broad.mit.edu	37	12	105150997	105150997	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr12:105150997G>A	uc001tkx.1	+	4	766	c.475G>A	c.(475-477)GCC>ACC	p.A159T	CHST11_uc001tky.2_Missense_Mutation_p.A154T|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	159	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						ACACGTCTCCGCCAACCTGAA	0.592000												
CLIP1	6249	broad.mit.edu	37	12	122757592	122757592	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr12:122757592C>T	uc001ucg.1	-	25	4253	c.4147G>A	c.(4147-4149)GAC>AAC	p.D1383N	CLIP1_uc001uch.1_Missense_Mutation_p.D1372N|CLIP1_uc001uci.1_Missense_Mutation_p.D1337N|CLIP1_uc001ucf.1_Missense_Mutation_p.D42N	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1383					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TCAAAGCAGTCACAAATGTCA	0.468000												
MAB21L1	4081	broad.mit.edu	37	13	36049251	36049251	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr13:36049251G>A	uc001uvc.2	-	1	1582	c.1025C>T	c.(1024-1026)ACG>ATG	p.T342M	NBEA_uc001uvb.2_Intron|NBEA_uc010abi.2_Intron|NBEA_uc010tee.1_Intron|NBEA_uc010tef.1_5'Flank|NBEA_uc010teg.1_5'Flank	NM_005584	NP_005575	Q13394	MB211_HUMAN	mab-21-like protein 1	342					anatomical structure morphogenesis	nucleus				ovary(2)	2		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CAGTCGCCACGTTTGTTTGGC	0.473000												
ATP11A	23250	broad.mit.edu	37	13	113526064	113526064	+	Missense_Mutation	SNP	A	A	G			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr13:113526064A>G	uc001vsi.3	+	26	3095	c.3007A>G	c.(3007-3009)ACG>GCG	p.T1003A	ATP11A_uc001vsj.3_Missense_Mutation_p.T1003A|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1003	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				TGGAAACTGGACGTTTGGAAC	0.428000												
OR4N2	390429	broad.mit.edu	37	14	20296316	20296316	+	Missense_Mutation	SNP	A	A	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr14:20296316A>T	uc010tkv.1	+	1	709	c.709A>T	c.(709-711)ATG>TTG	p.M237L		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	237	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAACAAGGCCATGTCCACGTG	0.502000												
OR4K13	390433	broad.mit.edu	37	14	20502652	20502652	+	Missense_Mutation	SNP	C	C	A	rs138902767		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr14:20502652C>A	uc010tkz.1	-	1	266	c.266G>T	c.(265-267)CGT>CTT	p.R89L		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GATGGTCTTACGTTCTCGGAG	0.458000												
NIN	51199	broad.mit.edu	37	14	51243828	51243828	+	Missense_Mutation	SNP	A	A	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr14:51243828A>C	uc001wym.2	-	7	696	c.505T>G	c.(505-507)TTG>GTG	p.L169V	NIN_uc001wyi.2_Missense_Mutation_p.L169V|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.L169V|NIN_uc010tqp.1_Missense_Mutation_p.L175V|NIN_uc001wyo.2_Missense_Mutation_p.L169V|NIN_uc001wyp.1_Missense_Mutation_p.L131V	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	169					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GAAGCATTCAAGTCATCTGGG	0.448000			T	PDGFRB	MPD							
C14orf37	145407	broad.mit.edu	37	14	58605379	58605379	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr14:58605379G>A	uc001xdc.2	-	2	809	c.698C>T	c.(697-699)ACA>ATA	p.T233I	C14orf37_uc010tro.1_Missense_Mutation_p.T271I|C14orf37_uc001xdd.2_Missense_Mutation_p.T233I|C14orf37_uc001xde.2_Missense_Mutation_p.T233I	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	233	Extracellular (Potential).					integral to membrane	binding				0						AAAAGAAGTTGTCCTGTGGTC	0.483000												
PLEKHG3	26030	broad.mit.edu	37	14	65207762	65207762	+	Silent	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr14:65207762G>A	uc001xho.1	+	16	1796	c.1527G>A	c.(1525-1527)CCG>CCA	p.P509P	PLEKHG3_uc001xhn.1_Silent_p.P453P|PLEKHG3_uc001xhp.2_Silent_p.P630P|PLEKHG3_uc010aqh.1_Silent_p.P51P|PLEKHG3_uc001xhq.1_Silent_p.P14P	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	509					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		AGGTTGAGCCGGACCCTGAGG	0.552000												
GALNTL1	57452	broad.mit.edu	37	14	69805397	69805397	+	Missense_Mutation	SNP	G	G	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr14:69805397G>T	uc010aqu.1	+	10	1090	c.997G>T	c.(997-999)GGC>TGC	p.G333C	GALNTL1_uc001xla.1_Missense_Mutation_p.G333C|GALNTL1_uc001xlb.1_Missense_Mutation_p.G333C	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	333	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		GATGTGTGGTGGCAGTCTGGA	0.587000												
APBA2	321	broad.mit.edu	37	15	29346255	29346255	+	Silent	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr15:29346255C>T	uc001zck.2	+	3	375	c.168C>T	c.(166-168)CCC>CCT	p.P56P	APBA2_uc010azj.2_Silent_p.P56P|APBA2_uc010uat.1_Silent_p.P56P|APBA2_uc001zcl.2_Silent_p.P56P|APBA2_uc010uas.1_Silent_p.P56P	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	56					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CAGAGAGCCCCGCGCCAGAGG	0.657000												
DMXL2	23312	broad.mit.edu	37	15	51749571	51749571	+	Missense_Mutation	SNP	G	G	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr15:51749571G>C	uc002abf.2	-	36	8450	c.8225C>G	c.(8224-8226)TCT>TGT	p.S2742C	DMXL2_uc002abd.2_Missense_Mutation_p.S834C|DMXL2_uc010ufy.1_Missense_Mutation_p.S2743C|DMXL2_uc010bfa.2_Missense_Mutation_p.S2106C	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2742						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CCATGGCAGAGATGAAGGTGG	0.428000												
BBS4	585	broad.mit.edu	37	15	73029293	73029293	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr15:73029293C>T	uc002avb.2	+	15	1482	c.1439C>T	c.(1438-1440)ACG>ATG	p.T480M	BBS4_uc010ukv.1_Missense_Mutation_p.T468M|BBS4_uc002avc.2_Missense_Mutation_p.T308M|BBS4_uc002avd.2_Missense_Mutation_p.T488M	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	480	Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						GCATACAGGACGCTCCCCTCA	0.522000									Bardet-Biedl_syndrome			
ACAN	176	broad.mit.edu	37	15	89391173	89391173	+	Missense_Mutation	SNP	G	G	A	rs62640041		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr15:89391173G>A	uc010upo.1	+	9	2010	c.1636G>A	c.(1636-1638)GTG>ATG	p.V546M	ACAN_uc002bmx.2_Missense_Mutation_p.V546M|ACAN_uc010upp.1_Missense_Mutation_p.V546M|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	546					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GACCCCATGCGTGGGTGACAA	0.592000												
IL21R	50615	broad.mit.edu	37	16	27460309	27460309	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr16:27460309C>T	uc002doq.1	+	9	1555	c.1322C>T	c.(1321-1323)CCC>CTC	p.P441L	IL21R_uc002dor.1_Missense_Mutation_p.P441L|IL21R_uc002dos.1_Missense_Mutation_p.P441L|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	441	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CTAGGAGGGCCCCTGGGAAGC	0.667000			T	BCL6	NHL							
CES7	221223	broad.mit.edu	37	16	55880585	55880585	+	Silent	SNP	A	A	G			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr16:55880585A>G	uc002eip.2	-	13	1655	c.1506T>C	c.(1504-1506)AAT>AAC	p.N502N	CES7_uc002eio.2_Silent_p.N452N|CES7_uc002eiq.2_Silent_p.N263N|CES7_uc002eir.2_Silent_p.N396N	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	502						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		GGTCGTTCCCATTAGGATTCC	0.547000												
GOT2	2806	broad.mit.edu	37	16	58752443	58752443	+	Silent	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr16:58752443C>T	uc002eof.1	-	5	699	c.585G>A	c.(583-585)GTG>GTA	p.V195V	GOT2_uc010vim.1_Silent_p.V152V	NM_002080	NP_002071	P00505	AATM_HUMAN	aspartate aminotransferase 2 precursor	195					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAATATCCTCCACAGCGCCTG	0.488000												
CDH8	1006	broad.mit.edu	37	16	61823293	61823293	+	Silent	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr16:61823293T>C	uc002eog.1	-	8	1623	c.1371A>G	c.(1369-1371)GAA>GAG	p.E457E	CDH8_uc002eoh.2_Silent_p.E226E	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	457	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ATACACTTAATTCTCTGTCAA	0.413000												
PITPNM3	83394	broad.mit.edu	37	17	6368010	6368010	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr17:6368010C>T	uc002gdd.3	-	15	2123	c.1972G>A	c.(1972-1974)GGG>AGG	p.G658R	PITPNM3_uc010cln.2_Missense_Mutation_p.G622R|PITPNM3_uc010clm.2_Missense_Mutation_p.G141R|PITPNM3_uc002gdc.3_Missense_Mutation_p.G249R	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	658					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		TCGAGGGGCCCGTACATGAAC	0.607000												
TP53	7157	broad.mit.edu	37	17	7577497	7577497	+	Splice_Site	SNP	A	A	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr17:7577497A>C	uc002gim.2	-	7	976	c.782_splice	c.e7+1	p.S261_splice	TP53_uc002gig.1_Splice_Site_p.R261_splice|TP53_uc002gih.2_Splice_Site_p.S261_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.S129_splice|TP53_uc010cng.1_Splice_Site_p.S129_splice|TP53_uc002gii.1_Splice_Site_p.S129_splice|TP53_uc010cnh.1_Splice_Site_p.S261_splice|TP53_uc010cni.1_Splice_Site_p.S261_splice|TP53_uc002gij.2_Splice_Site_p.S261_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(3)|p.E258fs*71(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGCTCCTGACCTGGAGTCT	0.572000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
FOXN1	8456	broad.mit.edu	37	17	26851007	26851007	+	Missense_Mutation	SNP	C	C	T	rs148865374	byFrequency	TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr17:26851007C>T	uc010crm.2	+	2	218	c.20C>T	c.(19-21)CCG>CTG	p.P7L	FOXN1_uc002hbj.2_Missense_Mutation_p.P7L	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	7					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CTACCCCCGCCGCAGTCTGAC	0.677000												
AARSD1	80755	broad.mit.edu	37	17	41108328	41108328	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr17:41108328G>A	uc002icc.2	-	6	559	c.556C>T	c.(556-558)CGG>TGG	p.R186W	AARSD1_uc002icd.2_Missense_Mutation_p.R299W|AARSD1_uc002ice.2_Missense_Mutation_p.R269W|AARSD1_uc002icf.2_Missense_Mutation_p.R360W|AARSD1_uc010whg.1_Missense_Mutation_p.R360W|AARSD1_uc010cyu.1_Missense_Mutation_p.R186W	NM_025267	NP_079543	Q9BTE6	AASD1_HUMAN	alanyl-tRNA synthetase domain containing 1	186					alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GGCAAACCCCGGCCACTCACC	0.542000												
TMC6	11322	broad.mit.edu	37	17	76121030	76121030	+	Silent	SNP	G	G	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr17:76121030G>C	uc002juj.1	-	6	699	c.573C>G	c.(571-573)GGC>GGG	p.G191G	TMC6_uc002jui.1_5'Flank|TMC6_uc010dhf.1_Silent_p.G24G|TMC6_uc002juk.2_Silent_p.G191G|TMC6_uc010dhg.1_Silent_p.G191G|TMC6_uc002jul.1_Silent_p.G191G|TMC6_uc002jum.3_Silent_p.G24G|TMC6_uc002jun.3_Silent_p.G191G|TMC6_uc002juo.2_Intron|TMC6_uc010wtp.1_Silent_p.G24G	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	191	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TGCCCGGCTGGCCCCTCCACT	0.692000									Epidermodysplasia_Verruciformis_Familial_Clustering_of			
ZNF536	9745	broad.mit.edu	37	19	31040279	31040279	+	Silent	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr19:31040279G>A	uc002nsu.1	+	4	3891	c.3753G>A	c.(3751-3753)CCG>CCA	p.P1251P	ZNF536_uc010edd.1_Silent_p.P1251P	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGCCAAAGCCGGAGCGGGGGC	0.607000												
PPFIA3	8541	broad.mit.edu	37	19	49646220	49646220	+	Missense_Mutation	SNP	G	G	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr19:49646220G>T	uc002pmr.2	+	21	3036	c.2704G>T	c.(2704-2706)GTC>TTC	p.V902F	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Missense_Mutation_p.V770F|PPFIA3_uc002pmt.2_Missense_Mutation_p.V50F	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	902	SAM 1.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		CCAGGAGATGGTCTCGCTCAC	0.652000												
ZNF530	348327	broad.mit.edu	37	19	58118470	58118470	+	Missense_Mutation	SNP	A	A	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr19:58118470A>C	uc002qpk.2	+	3	1797	c.1577A>C	c.(1576-1578)AAA>ACA	p.K526T	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	526	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAATGTGGGAAATCCTATAGC	0.453000												
MXD1	4084	broad.mit.edu	37	2	70165237	70165237	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr2:70165237G>A	uc002sfy.2	+	6	747	c.487G>A	c.(487-489)GAC>AAC	p.D163N	MXD1_uc010yqp.1_Missense_Mutation_p.D162N|MXD1_uc010yqq.1_Missense_Mutation_p.D100N|MXD1_uc010yqr.1_RNA|MXD1_uc010yqs.1_Missense_Mutation_p.D153N	NM_002357	NP_002348	Q05195	MAD1_HUMAN	MAX dimerization protein 1	163					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						AGAAGAAATCGACGTTGACGT	0.453000												
ADD2	119	broad.mit.edu	37	2	70910804	70910804	+	Silent	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr2:70910804G>A	uc002sgz.2	-	10	1509	c.1044C>T	c.(1042-1044)GCC>GCT	p.A348A	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Silent_p.A348A|ADD2_uc002sha.2_Intron|ADD2_uc002sgx.2_Silent_p.A348A|ADD2_uc010fdt.1_Silent_p.A348A|ADD2_uc002shc.1_Silent_p.A348A|ADD2_uc002shd.1_Intron|ADD2_uc010fdu.1_Silent_p.A364A	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	348					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						AGGTGCTCCCGGCCCACTGCA	0.627000												
TGFBRAP1	9392	broad.mit.edu	37	2	105890146	105890146	+	Missense_Mutation	SNP	A	A	G			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr2:105890146A>G	uc002tcq.2	-	9	1751	c.1667T>C	c.(1666-1668)GTC>GCC	p.V556A	TGFBRAP1_uc010fjc.2_Intron|TGFBRAP1_uc002tcr.3_Missense_Mutation_p.V556A	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	556					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						CTGAACTCCGACCTGAAAGAG	0.398000												
IL1F6	27179	broad.mit.edu	37	2	113763626	113763626	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr2:113763626C>T	uc010yxr.1	+	2	86	c.86C>T	c.(85-87)ACG>ATG	p.T29M		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	29					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						CAGGACCAGACGCTCATAGCA	0.498000												
LYPD1	116372	broad.mit.edu	37	2	133403681	133403681	+	Silent	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr2:133403681G>A	uc002ttn.2	-	3	1339	c.363C>T	c.(361-363)CTC>CTT	p.L121L	GPR39_uc002ttl.2_3'UTR|LYPD1_uc002ttm.3_Silent_p.L137L|LYPD1_uc002tto.2_Silent_p.L69L	NM_144586	NP_653187	Q8N2G4	LYPD1_HUMAN	LY6/PLAUR domain containing 1 isoform a	121						anchored to membrane|plasma membrane					0						GCCCTGGCCTGAGGGCCGAGG	0.572000												
XRCC5	7520	broad.mit.edu	37	2	216997075	216997075	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr2:216997075C>T	uc002vfy.2	+	10	1218	c.1078C>T	c.(1078-1080)CAA>TAA	p.Q360*	XRCC5_uc002vfz.2_Nonsense_Mutation_p.Q246*	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	360	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		CATGGGAAATCAAGTTCTAAA	0.383000								Direct_reversal_of_damage|NHEJ				
CXCR2	3579	broad.mit.edu	37	2	218999946	218999946	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr2:218999946G>A	uc002vgz.1	+	4	647	c.422G>A	c.(421-423)AGT>AAT	p.S141N	CXCR2_uc002vha.1_Missense_Mutation_p.S141N|CXCR2_uc002vhb.1_Missense_Mutation_p.S141N	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	141	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						GCCTGCATCAGTGTGGACCGT	0.512000												
SP140	11262	broad.mit.edu	37	2	231152636	231152636	+	Missense_Mutation	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr2:231152636T>C	uc002vql.2	+	18	1790	c.1675T>C	c.(1675-1677)TTC>CTC	p.F559L	SP140_uc010zma.1_RNA|SP140_uc002vqn.2_Missense_Mutation_p.F445L|SP140_uc002vqm.2_Missense_Mutation_p.F499L|SP140_uc010fxl.2_Missense_Mutation_p.F532L	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	559					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TGGAACCCGCTTCACTCAGAG	0.378000												
CCDC116	164592	broad.mit.edu	37	22	21991296	21991296	+	Silent	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr22:21991296T>C	uc002zve.2	+	5	1872	c.1779T>C	c.(1777-1779)GAT>GAC	p.D593D		NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	Error:Variant_position_missing_in_Q8IYX3_after_alignment										ovary(1)|skin(1)	2	Colorectal(54;0.105)					AGATTGAAGATGAAGATGagg	0.448000												
IGLL1	3543	broad.mit.edu	37	22	23917253	23917253	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr22:23917253C>T	uc002zxd.2	-	2	341	c.223G>A	c.(223-225)GGC>AGC	p.G75S	IGLL1_uc002zxe.2_Intron	NM_020070	NP_064455	P15814	IGLL1_HUMAN	immunoglobulin lambda-like polypeptide 1 isoform	75					immune response	extracellular region|membrane					0						GTCCAGGAGCCGCGCTGGAGC	0.632000												
MYO18B	84700	broad.mit.edu	37	22	26173746	26173746	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr22:26173746C>A	uc003abz.1	+	8	2316	c.2066C>A	c.(2065-2067)TCA>TAA	p.S689*	MYO18B_uc003aca.1_Nonsense_Mutation_p.S570*|MYO18B_uc010guy.1_Nonsense_Mutation_p.S570*|MYO18B_uc010guz.1_Nonsense_Mutation_p.S570*|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_Nonsense_Mutation_p.S202*	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	689	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGCAGGGTCTCAGGTATGGTG	0.542000												
CAMK1	8536	broad.mit.edu	37	3	9804598	9804598	+	Silent	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr3:9804598C>T	uc003bst.2	-	5	607	c.429G>A	c.(427-429)AAG>AAA	p.K143K	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_RNA|CAMK1_uc003bss.2_5'Flank|uc003bsv.1_RNA	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	143	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		TGAGCCCCACCTTGAGATCCC	0.488000												
STT3B	201595	broad.mit.edu	37	3	31661247	31661247	+	Silent	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr3:31661247C>T	uc011axe.1	+	9	1252	c.1252C>T	c.(1252-1254)CTA>TTA	p.L418L	STT3B_uc010hft.1_Intron|STT3B_uc003cer.1_Silent_p.L418L|STT3B_uc003cet.2_Silent_p.L169L	NM_178862	NP_849193	Q8TCJ2	STT3B_HUMAN	source of immunodominant MHC-associated	418	Helical; (Potential).				protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0						CTTCTTTGATCTACATATTCT	0.348000												
EXOG	9941	broad.mit.edu	37	3	38542927	38542927	+	Missense_Mutation	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr3:38542927T>C	uc003cih.2	+	3	491	c.395T>C	c.(394-396)GTT>GCT	p.V132A	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Missense_Mutation_p.V82A|EXOG_uc003cij.2_5'UTR|EXOG_uc010hhd.2_5'UTR|EXOG_uc010hhe.2_5'UTR|EXOG_uc003cik.2_5'UTR|EXOG_uc010hhf.2_5'UTR|EXOG_uc003cii.2_5'UTR	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	132						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						GAAGATTATGTTGGAAGTGGG	0.443000												
LARS2	23395	broad.mit.edu	37	3	45559430	45559430	+	Nonsense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr3:45559430C>T	uc003cop.1	+	18	2265	c.2080C>T	c.(2080-2082)CGA>TGA	p.R694*	LARS2_uc010hit.1_Nonsense_Mutation_p.R651*	NM_015340	NP_056155	Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	694					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity	p.R694*(1)		upper_aerodigestive_tract(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	ATGGCAACAACGACTGTGGAC	0.507000												
EPHA3	2042	broad.mit.edu	37	3	89468434	89468434	+	Missense_Mutation	SNP	A	A	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr3:89468434A>C	uc003dqy.2	+	11	2193	c.1968A>C	c.(1966-1968)AAA>AAC	p.K656N	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	656	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AGACCCTGAAAGTTGGCTACA	0.438000										TSP Lung(6;0.00050)		
PAQR9	344838	broad.mit.edu	37	3	142681581	142681581	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr3:142681581C>T	uc003evg.2	-	1	598	c.598G>A	c.(598-600)GTG>ATG	p.V200M	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	200	Extracellular (Potential).					integral to membrane	receptor activity				0						GTGCAGTCCACGTGCCAGCCC	0.647000												
PLOD2	5352	broad.mit.edu	37	3	145789117	145789117	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr3:145789117G>A	uc003evs.1	-	17	2385	c.1879C>T	c.(1879-1881)CGG>TGG	p.R627W	PLOD2_uc003evq.1_Missense_Mutation_p.R308W|PLOD2_uc011bnm.1_Missense_Mutation_p.R593W|PLOD2_uc003evr.1_Missense_Mutation_p.R648W	NM_000935	NP_000926	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	627					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2					Vitamin C(DB00126)	ATGAACTCCCGGATAAAATGA	0.413000												
DLG1	1739	broad.mit.edu	37	3	196778537	196778537	+	Missense_Mutation	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr3:196778537T>C	uc003fxo.3	-	25	2709	c.2519A>G	c.(2518-2520)GAA>GGA	p.E840G	DLG1_uc011bub.1_Missense_Mutation_p.E736G|DLG1_uc011buc.1_Missense_Mutation_p.E724G|DLG1_uc011bud.1_Missense_Mutation_p.E523G|DLG1_uc003fxn.3_Missense_Mutation_p.E862G|DLG1_uc011bue.1_Missense_Mutation_p.E828G|DLG1_uc010ial.2_Missense_Mutation_p.E840G	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	840	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		CTTATTCATTTCCCTACGAAA	0.323000												
BOD1L	259282	broad.mit.edu	37	4	13603233	13603233	+	Missense_Mutation	SNP	T	T	C	rs151182576		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr4:13603233T>C	uc003gmz.1	-	10	5408	c.5291A>G	c.(5290-5292)GAT>GGT	p.D1764G	BOD1L_uc010idr.1_Missense_Mutation_p.D1101G	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1764							DNA binding			ovary(5)|breast(1)	6						TGCATCATTATCTCCCAGGAC	0.527000												
FAM13A	10144	broad.mit.edu	37	4	89772203	89772203	+	Silent	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr4:89772203T>C	uc003hse.1	-	7	1183	c.975A>G	c.(973-975)GCA>GCG	p.A325A	FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsh.1_Silent_p.A139A	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	325					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						TAGCACCCTCTGCTGAATTCA	0.453000												
TARS	6897	broad.mit.edu	37	5	33455057	33455057	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr5:33455057G>A	uc003jhy.2	+	5	756	c.461G>A	c.(460-462)TGG>TAG	p.W154*	TARS_uc011cob.1_Nonsense_Mutation_p.W142*|TARS_uc010iup.1_Nonsense_Mutation_p.W95*|TARS_uc011coc.1_Nonsense_Mutation_p.W175*|TARS_uc003jhz.2_Nonsense_Mutation_p.W50*|TARS_uc011cod.1_Intron	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	154					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	CAGGTGTATTGGCACTCTAGT	0.383000												
APC	324	broad.mit.edu	37	5	112162891	112162891	+	Nonsense_Mutation	SNP	C	C	T	rs137854580		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr5:112162891C>T	uc010jby.2	+	12	1875	c.1495C>T	c.(1495-1497)CGA>TGA	p.R499*	APC_uc011cvt.1_Nonsense_Mutation_p.R481*|APC_uc003kpz.3_Nonsense_Mutation_p.R499*|APC_uc003kpy.3_Nonsense_Mutation_p.R499*|APC_uc010jbz.2_Nonsense_Mutation_p.R216*|APC_uc010jca.2_Intron	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	499	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.R499*(2)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TACACTAAGACGATATGCTGG	0.373000		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)		
PCDHB10	56126	broad.mit.edu	37	5	140572514	140572514	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr5:140572514C>T	uc003lix.2	+	1	563	c.389C>T	c.(388-390)GCG>GTG	p.A130V		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	130	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATGATCACGCGCCAGTATTT	0.423000												
MDGA1	266727	broad.mit.edu	37	6	37626035	37626035	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr6:37626035C>T	uc003onu.1	-	3	1547	c.368G>A	c.(367-369)CGC>CAC	p.R123H		NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	123	Ig-like 1.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						CACGTCCACGCGGATGGACTT	0.682000												
LRFN2	57497	broad.mit.edu	37	6	40399786	40399786	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr6:40399786G>A	uc003oph.1	-	2	1532	c.1067C>T	c.(1066-1068)GCC>GTC	p.A356V		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	356	Extracellular (Potential).|Ig-like.					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCAGGTGAAGGCACCACTGTC	0.602000												
MYB	4602	broad.mit.edu	37	6	135517008	135517008	+	Silent	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr6:135517008G>A	uc003qfc.2	+	9	1270	c.1071G>A	c.(1069-1071)CTG>CTA	p.L357L	MYB_uc003qfh.2_Silent_p.L357L|MYB_uc003qfi.2_Silent_p.L357L|MYB_uc010kgi.2_Silent_p.L357L|MYB_uc003qfq.2_Silent_p.L354L|MYB_uc010kgj.2_Silent_p.L322L|MYB_uc003qfo.2_Intron|MYB_uc003qfu.2_Silent_p.L354L|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_Intron|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_5'UTR|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Silent_p.L169L|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Silent_p.L357L|MYB_uc003qge.1_RNA	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	357	Negative regulatory domain (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		CTCCATCTCTGCCAGCGGATC	0.567000			T	NFIB	adenoid cystic carcinoma							
GRM1	2911	broad.mit.edu	37	6	146480704	146480704	+	Silent	SNP	C	C	T	rs150520977		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr6:146480704C>T	uc010khw.1	+	3	1391	c.921C>T	c.(919-921)GGC>GGT	p.G307G	GRM1_uc010khu.1_Silent_p.G307G|GRM1_uc010khv.1_Silent_p.G307G|GRM1_uc003qll.2_Silent_p.G307G|GRM1_uc011edz.1_Silent_p.G307G|GRM1_uc011eea.1_Silent_p.G307G	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	307	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGCGCCTTGGCGTCGTGGGCG	0.398000												
HEATR2	54919	broad.mit.edu	37	7	813704	813704	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr7:813704G>A	uc010krz.1	+	10	1971	c.1951G>A	c.(1951-1953)GAG>AAG	p.E651K	HEATR2_uc003siz.2_Missense_Mutation_p.E519K|HEATR2_uc003sjb.2_Missense_Mutation_p.E31K|HEATR2_uc003sjc.2_Missense_Mutation_p.E76K	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	651							protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CAGCTACCTCGAGACGGTGAC	0.632000												
POLM	27434	broad.mit.edu	37	7	44120346	44120346	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr7:44120346G>A	uc003tjt.2	-	2	450	c.358C>T	c.(358-360)CGG>TGG	p.R120W	POLM_uc003tju.2_Missense_Mutation_p.R120W|POLM_uc003tjx.2_Missense_Mutation_p.R120W|POLM_uc003tjv.2_RNA|POLM_uc011kbt.1_5'UTR|POLM_uc003tka.1_5'Flank|POLM_uc003tjz.3_Missense_Mutation_p.R120W|POLM_uc011kbu.1_Missense_Mutation_p.R120W|POLM_uc010kxy.2_Missense_Mutation_p.R120W	NM_013284	NP_037416	Q9NP87	DPOLM_HUMAN	DNA-directed DNA polymerase mu	120	BRCT.				DNA recombination|DNA repair	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3						AGGCGGTGCCGGCACTCCACA	0.627000								DNA_polymerases_(catalytic_subunits)				
PKD1L1	168507	broad.mit.edu	37	7	47937792	47937792	+	Splice_Site	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr7:47937792C>T	uc003tny.1	-	14	2065	c.2065_splice	c.e14-1	p.I689_splice		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1						cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ACCTCCATATCTAAGTATCAA	0.398000												
AKAP9	10142	broad.mit.edu	37	7	91731945	91731945	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr7:91731945G>A	uc003ulg.2	+	46	11360	c.11135G>A	c.(11134-11136)CGA>CAA	p.R3712Q	AKAP9_uc003ulf.2_Missense_Mutation_p.R3704Q|AKAP9_uc003uli.2_Missense_Mutation_p.R3335Q|AKAP9_uc003ulj.2_Missense_Mutation_p.R1482Q|AKAP9_uc003ull.2_Missense_Mutation_p.R608Q	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3716					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAAAGTTTTCGAAAGGCTCTC	0.458000			T	BRAF	papillary thyroid							
TAS2R5	54429	broad.mit.edu	37	7	141491041	141491041	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr7:141491041C>T	uc003vwr.1	+	1	1025	c.880C>T	c.(880-882)CGG>TGG	p.R294W		NM_018980	NP_061853	Q9NYW4	TA2R5_HUMAN	taste receptor T2R5	294	Cytoplasmic (Potential).				chemosensory behavior|sensory perception of taste		taste receptor activity				0	Melanoma(164;0.0171)					AGTGTGTGCTCGGAGATGCTG	0.493000												
ADAM28	10863	broad.mit.edu	37	8	24184071	24184071	+	Missense_Mutation	SNP	A	A	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr8:24184071A>C	uc003xdy.2	+	10	978	c.895A>C	c.(895-897)ACA>CCA	p.T299P	ADAM28_uc003xdx.2_Missense_Mutation_p.T299P|ADAM28_uc011kzz.1_Missense_Mutation_p.T66P|ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_5'UTR	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	299	Peptidase M12B.|Extracellular (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TTGCAGAGCAACAGAACTTGC	0.358000												
DPYS	1807	broad.mit.edu	37	8	105463594	105463594	+	Silent	SNP	G	G	A	rs141057778		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr8:105463594G>A	uc003yly.3	-	2	432	c.303C>T	c.(301-303)TTC>TTT	p.F101F		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	101					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGGAATGGCGAAATCAATAA	0.468000												
LRP12	29967	broad.mit.edu	37	8	105510027	105510027	+	Missense_Mutation	SNP	C	C	G			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr8:105510027C>G	uc003yma.2	-	5	848	c.753G>C	c.(751-753)GAG>GAC	p.E251D	LRP12_uc003ymb.2_Missense_Mutation_p.E232D|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	251	Extracellular (Potential).|LDL-receptor class A 2.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CACAGTCTATCTCATCTCCTA	0.398000												
CSMD3	114788	broad.mit.edu	37	8	113326718	113326718	+	Missense_Mutation	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr8:113326718T>C	uc003ynu.2	-	48	7648	c.7489A>G	c.(7489-7491)ACC>GCC	p.T2497A	CSMD3_uc003yns.2_Missense_Mutation_p.T1699A|CSMD3_uc003ynt.2_Missense_Mutation_p.T2457A|CSMD3_uc011lhx.1_Missense_Mutation_p.T2393A|CSMD3_uc003ynw.1_Missense_Mutation_p.T208A	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2497	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACAAACATGGTGATATTATAA	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
EPPK1	83481	broad.mit.edu	37	8	144940350	144940350	+	Missense_Mutation	SNP	G	G	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr8:144940350G>C	uc003zaa.1	-	2	15095	c.15082C>G	c.(15082-15084)CCC>GCC	p.P5028A		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5028	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACGTCCACGGGCACGCGGTGG	0.687000												
RNF38	152006	broad.mit.edu	37	9	36339763	36339763	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr9:36339763G>A	uc003zzh.2	-	12	1725	c.1534C>T	c.(1534-1536)CGG>TGG	p.R512W	RNF38_uc003zzi.2_Missense_Mutation_p.R462W|RNF38_uc003zzj.2_Missense_Mutation_p.R429W|RNF38_uc003zzk.2_Missense_Mutation_p.R429W|RNF38_uc003zzl.2_Missense_Mutation_p.R436W|RNF38_uc003zzm.2_Missense_Mutation_p.R429W	NM_022781	NP_073618	Q9H0F5	RNF38_HUMAN	ring finger protein 38 isoform 1	512							zinc ion binding			central_nervous_system(1)	1			STAD - Stomach adenocarcinoma(86;0.228)			TCTGAATCCCGATGCACTTCT	0.388000												
ZNF462	58499	broad.mit.edu	37	9	109686821	109686821	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr9:109686821G>A	uc004bcz.2	+	3	917	c.628G>A	c.(628-630)GTA>ATA	p.V210I	ZNF462_uc010mto.2_Missense_Mutation_p.V58I|ZNF462_uc004bda.2_Missense_Mutation_p.V58I	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	210					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						GGTTCCGCCCGTATCACTGCA	0.507000												
TLR4	7099	broad.mit.edu	37	9	120475034	120475034	+	Missense_Mutation	SNP	C	C	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr9:120475034C>A	uc004bjz.2	+	3	919	c.628C>A	c.(628-630)CTG>ATG	p.L210M	TLR4_uc004bka.2_Missense_Mutation_p.L170M|TLR4_uc004bkb.2_Missense_Mutation_p.L10M	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	210	LRR 7.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CTCTTTAGACCTGTCCCTGAA	0.368000												
ACOT9	23597	broad.mit.edu	37	X	23724827	23724827	+	Missense_Mutation	SNP	A	A	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chrX:23724827A>T	uc004dap.2	-	10	879	c.733T>A	c.(733-735)TCC>ACC	p.S245T	ACOT9_uc004dan.2_5'UTR|ACOT9_uc004dao.2_Missense_Mutation_p.S254T|ACOT9_uc004daq.2_Missense_Mutation_p.S203T|ACOT9_uc004dar.2_Missense_Mutation_p.S185T|ACOT9_uc011mjt.1_RNA|ACOT9_uc004das.2_Missense_Mutation_p.S185T	NM_001033583	NP_001028755	Q9Y305	ACOT9_HUMAN	acyl-Coenzyme A thioesterase 2, mitochondrial	245					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(2)|pancreas(1)	3						AACGACGTGGAGCTGAAGGCA	0.507000												
MAGEB6	158809	broad.mit.edu	37	X	26212897	26212897	+	Missense_Mutation	SNP	G	G	A			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chrX:26212897G>A	uc004dbr.2	+	2	1083	c.934G>A	c.(934-936)GGT>AGT	p.G312S	MAGEB6_uc010ngc.1_Missense_Mutation_p.G92S	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	312	MAGE.									ovary(3)	3						GGAGTTCCTGGGTCTGTTGGG	0.498000												
FAM47A	158724	broad.mit.edu	37	X	34148843	34148843	+	Missense_Mutation	SNP	C	C	T			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chrX:34148843C>T	uc004ddg.2	-	1	1586	c.1553G>A	c.(1552-1554)CGC>CAC	p.R518H		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	518										ovary(4)|central_nervous_system(1)	5						AGGCTCCGAGCGGAGACTGGA	0.652000												
TMEM47	83604	broad.mit.edu	37	X	34648573	34648573	+	Missense_Mutation	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chrX:34648573T>C	uc004ddh.2	-	3	662	c.403A>G	c.(403-405)ATC>GTC	p.I135V	TMEM47_uc010ngs.2_RNA	NM_031442	NP_113630	Q9BQJ4	TMM47_HUMAN	transmembrane protein 47	135	Helical; (Potential).					integral to membrane				lung(1)	1						ATGAACTTGATTGGGTAAAGG	0.368000												
PFKFB1	5207	broad.mit.edu	37	X	54959866	54959866	+	Silent	SNP	T	T	C			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chrX:54959866T>C	uc004dty.1	-	14	1457	c.1386A>G	c.(1384-1386)GAA>GAG	p.E462E	PFKFB1_uc010nkd.1_Silent_p.E270E|PFKFB1_uc011mol.1_Silent_p.E397E	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	462	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						TATCCAGGGCTTCCTCAGGTT	0.547000												
SLC6A8	6535	broad.mit.edu	37	X	152960203	152960203	+	Silent	SNP	C	C	T	rs140601882		TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chrX:152960203C>T	uc004fib.3	+	12	1904	c.1626C>T	c.(1624-1626)TAC>TAT	p.Y542Y	SLC6A8_uc004fic.3_Silent_p.Y532Y|SLC6A8_uc011myx.1_Silent_p.Y427Y|SLC6A8_uc010nuj.2_RNA	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	542	Extracellular (Potential).				creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	TTGTGTACTACGAGCCGCTGG	0.483000												
HECW1	23072	broad.mit.edu	37	7	43540325	43540325	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F1-6875-01A-11D-2053-08	TCGA-F1-6875-11A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea1cac20-88c1-4257-9cdb-d2890eb2e123	f3a4fd8d-1f1c-48ab-854f-6717fd62c46c	g.chr7:43540324_43540324AG>A	uc003tid.1	+	19	4069	c.3464_3464AG>A	c.(3463-3465)gagfs	p.E1155fs	HECW1_uc011kbi.1_Frame_Shift_Del_p.E1121fs	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	Homo sapiens HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), mRNA.	1155					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						ATTCGGACTGAGGGTAATCAC	0.443