Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
TAS1R3	83756	broad.mit.edu	37	1	1268161	1268161	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:1268161C>T	uc010nyk.1	+	3	1250	c.1250C>T	c.(1249-1251)GCG>GTG	p.A417V		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	417	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	GGCTGCCCCGCGCAGGACCCC	0.652												
CASZ1	54897	broad.mit.edu	37	1	10700034	10700034	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:10700034C>T	uc001aro.2	-	21	4565	c.4245G>A	c.(4243-4245)CGG>CGA	p.R1415R		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CCGTCTTCCGCCGCTTGCCGA	0.632												
MTOR	2475	broad.mit.edu	37	1	11188135	11188135	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:11188135G>A	uc001asd.2	-	43	6080	c.5959C>T	c.(5959-5961)CGG>TGG	p.R1987W	MTOR_uc001asc.2_Missense_Mutation_p.R192W	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1987					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						GCATTGTGCCGGGCTGTCGTG	0.527												
PUM1	9698	broad.mit.edu	37	1	31414062	31414062	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:31414062T>A	uc001bsi.1	-	20	3285	c.3172A>T	c.(3172-3174)AAA>TAA	p.K1058*	PUM1_uc001bsf.1_Nonsense_Mutation_p.K726*|PUM1_uc001bsg.1_Nonsense_Mutation_p.K792*|PUM1_uc001bsh.1_Nonsense_Mutation_p.K1060*|PUM1_uc001bsj.1_Nonsense_Mutation_p.K1034*|PUM1_uc010oga.1_Nonsense_Mutation_p.K916*|PUM1_uc001bsk.1_Nonsense_Mutation_p.K1096*|PUM1_uc010ogb.1_Nonsense_Mutation_p.K999*|SNORD103A_uc009vts.1_Intron	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	1058	PUM-HD.|Pumilio 6.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		ATTTTGCTTTTATCCTCAGGA	0.383												
CACHD1	57685	broad.mit.edu	37	1	65157095	65157095	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:65157095G>A	uc001dbo.1	+	27	3628	c.3523G>A	c.(3523-3525)GAT>AAT	p.D1175N	CACHD1_uc001dbp.1_Missense_Mutation_p.D930N|CACHD1_uc001dbq.1_Missense_Mutation_p.D930N|CACHD1_uc010opa.1_Missense_Mutation_p.D419N	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1226	Cytoplasmic (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						GGGAAACCATGATGAGGACTT	0.522												
PDE4B	5142	broad.mit.edu	37	1	66827326	66827326	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:66827326T>C	uc001dcn.2	+	10	1061	c.870T>C	c.(868-870)TCT>TCC	p.S290S	PDE4B_uc009war.2_Silent_p.S198S|PDE4B_uc001dco.2_Silent_p.S290S|PDE4B_uc001dcp.2_Silent_p.S275S|PDE4B_uc001dcq.2_Silent_p.S118S|PDE4B_uc009was.2_Silent_p.S57S	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	290					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	AGATCCCATCTCCTACCCAGA	0.393												
LRRIQ3	127255	broad.mit.edu	37	1	74621436	74621436	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:74621436A>C	uc001dfy.3	-	4	880	c.688T>G	c.(688-690)TTA>GTA	p.L230V	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	230	IQ.									ovary(2)	2						TTTCTAACTAAGAAACCACGT	0.259												
LRRIQ3	127255	broad.mit.edu	37	1	74621467	74621467	+	Silent	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:74621467A>C	uc001dfy.3	-	4	849	c.657T>G	c.(655-657)GTT>GTG	p.V219V	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	219	IQ.									ovary(2)	2						GAACAATCAAAACTGGTGAAT	0.269												
ELTD1	64123	broad.mit.edu	37	1	79387375	79387376	+	Nonsense_Mutation	DNP	AG	AG	GT			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:79387375_79387376AG>GT	uc001diq.3	-	9	1335_1336	c.1179_1180CT>AC	c.(1177-1182)TACTCA>TAACCA	p.393_394YS>*P		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	393_394	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GTCTCATTTGAGTATGTCAGCT	0.436												
COL11A1	1301	broad.mit.edu	37	1	103449740	103449740	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:103449740A>T	uc001dul.2	-	31	2828	c.2510T>A	c.(2509-2511)CTT>CAT	p.L837H	COL11A1_uc001duk.2_Missense_Mutation_p.L28M|COL11A1_uc001dum.2_Missense_Mutation_p.L849H|COL11A1_uc001dun.2_Missense_Mutation_p.L798H|COL11A1_uc009weh.2_Missense_Mutation_p.L721H	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	837	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGAACTCCAAGTTTTCCCTA	0.209												
NTNG1	22854	broad.mit.edu	37	1	108023350	108023350	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:108023350A>G	uc001dvh.3	+	8	2226	c.1508A>G	c.(1507-1509)GAG>GGG	p.E503G	NTNG1_uc001dvf.3_Missense_Mutation_p.E444G|NTNG1_uc010out.1_Missense_Mutation_p.E469G|NTNG1_uc001dvc.3_Missense_Mutation_p.E402G|NTNG1_uc001dvi.2_Missense_Mutation_p.R71G|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_RNA|NTNG1_uc009wem.2_Silent_p.R65R	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	503					axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CTGCGGTGCGAGGAGGCTGGC	0.716												
HSD3B2	3284	broad.mit.edu	37	1	119958041	119958041	+	Translation_Start_Site	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:119958041C>T	uc001ehs.2	+	1	772	c.-1C>T	c.(-3-1)CACGA>CATGA		HSD3B2_uc001eht.2_Translation_Start_Site|HSD3B2_uc001ehu.2_Translation_Start_Site	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2						androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GGATTGGCCACGATGGGCTGG	0.542												
S100A7A	338324	broad.mit.edu	37	1	153390570	153390570	+	Silent	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:153390570T>A	uc001fbt.1	+	2	69	c.12T>A	c.(10-12)ACT>ACA	p.T4T		NM_176823	NP_789793	Q86SG5	S1A7A_HUMAN	S100 calcium binding protein A7-like 1	4						cytoplasm	calcium ion binding			skin(1)	1	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGAGCAACACTCAAGCTGAGA	0.423												
KIRREL	55243	broad.mit.edu	37	1	158064484	158064484	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:158064484T>C	uc001frn.3	+	15	2252	c.1848T>C	c.(1846-1848)TCT>TCC	p.S616S	KIRREL_uc010pib.1_Silent_p.S516S|KIRREL_uc009wsq.2_Silent_p.S452S|KIRREL_uc001fro.3_Silent_p.S430S|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	616	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					ACCGCCCGTCTTCCAGGGCAG	0.647												
CD1D	912	broad.mit.edu	37	1	158151310	158151310	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:158151310C>T	uc001frr.2	+	3	626	c.127C>T	c.(127-129)CGC>TGC	p.R43C	CD1D_uc009wsr.1_Missense_Mutation_p.R43C|CD1D_uc009wss.2_Missense_Mutation_p.R43C|CD1D_uc009wst.1_5'UTR	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	43	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CAGCTGGACGCGCACCGACGG	0.627												
OR10T2	128360	broad.mit.edu	37	1	158368853	158368853	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:158368853A>G	uc010pih.1	-	1	404	c.404T>C	c.(403-405)CTC>CCC	p.L135P		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GTTTATGATGAGTGTGTACCT	0.463												
SPTA1	6708	broad.mit.edu	37	1	158585082	158585082	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:158585082A>C	uc001fst.1	-	48	6911	c.6712T>G	c.(6712-6714)TTG>GTG	p.L2238V		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2238	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TGCTGAGCCAATCCAATGGTG	0.537												
SPTA1	6708	broad.mit.edu	37	1	158612297	158612297	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:158612297T>G	uc001fst.1	-	33	4840	c.4641A>C	c.(4639-4641)GAA>GAC	p.E1547D		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1547	Spectrin 15.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GGCCATCGACTTCATGTGCAA	0.423												
LY9	4063	broad.mit.edu	37	1	160793532	160793532	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:160793532A>C	uc001fwu.2	+	8	1826	c.1776A>C	c.(1774-1776)GAA>GAC	p.E592D	LY9_uc001fwv.2_Missense_Mutation_p.E578D|LY9_uc001fww.2_Missense_Mutation_p.E502D|LY9_uc001fwx.2_Missense_Mutation_p.E502D|LY9_uc001fwy.1_Missense_Mutation_p.E390D|LY9_uc001fwz.2_Missense_Mutation_p.E230D	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	592	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATGTCACGGAAGTTGAGTCTG	0.517												
HMCN1	83872	broad.mit.edu	37	1	186026528	186026528	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:186026528T>G	uc001grq.1	+	46	7536	c.7307T>G	c.(7306-7308)CTT>CGT	p.L2436R		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2436	Ig-like C2-type 22.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTGAGGATTCTTTCAGGTATT	0.383												
HMCN1	83872	broad.mit.edu	37	1	186122892	186122892	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:186122892A>C	uc001grq.1	+	97	15258	c.15029A>C	c.(15028-15030)GAG>GCG	p.E5010A	HMCN1_uc001grs.1_Missense_Mutation_p.E579A	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5010	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GATTACACAGAGGACTACATT	0.458												
CRB1	23418	broad.mit.edu	37	1	197390846	197390846	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:197390846T>G	uc001gtz.2	+	6	2023	c.1888T>G	c.(1888-1890)TTC>GTC	p.F630V	CRB1_uc010poz.1_Missense_Mutation_p.F561V|CRB1_uc010ppa.1_Intron|CRB1_uc009wza.2_Missense_Mutation_p.F518V|CRB1_uc010ppb.1_Missense_Mutation_p.F630V|CRB1_uc010ppc.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.F111V|CRB1_uc001gub.1_Missense_Mutation_p.F279V	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	630	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TCTGCTTAACTTCTATAATAT	0.418												
CACNA1S	779	broad.mit.edu	37	1	201039501	201039501	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:201039501C>T	uc001gvv.2	-	17	2486	c.2259G>A	c.(2257-2259)CCG>CCA	p.P753P		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	753	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GGGGGCTCAGCGGGATCTCAG	0.577												
KCNH1	3756	broad.mit.edu	37	1	211093380	211093380	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:211093380A>C	uc001hib.2	-	7	1234	c.1064T>G	c.(1063-1065)GTT>GGT	p.V355G	KCNH1_uc001hic.2_Missense_Mutation_p.V328G	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	355	Helical; Voltage-sensor; Name=Segment S4; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CAGCCGGACAACTTTTAGAGA	0.572												
FMN2	56776	broad.mit.edu	37	1	240370433	240370433	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:240370433A>G	uc010pyd.1	+	5	2546	c.2321A>G	c.(2320-2322)GAA>GGA	p.E774G	FMN2_uc010pye.1_Missense_Mutation_p.E778G	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	774	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCTGGGGCTGAAAGTGGACCT	0.572												
FMN2	56776	broad.mit.edu	37	1	240555835	240555835	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:240555835A>G	uc010pyd.1	+	15	5108	c.4883A>G	c.(4882-4884)GAA>GGA	p.E1628G	FMN2_uc010pye.1_Missense_Mutation_p.E1632G|FMN2_uc010pyf.1_Missense_Mutation_p.E243G|FMN2_uc010pyg.1_Missense_Mutation_p.E224G	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1628	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAGGCAGAGGAAAATTCACTG	0.348												
ARMC4	55130	broad.mit.edu	37	10	28270420	28270420	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr10:28270420T>G	uc009xky.2	-	7	1009	c.911A>C	c.(910-912)AAA>ACA	p.K304T	ARMC4_uc010qds.1_5'UTR|ARMC4_uc010qdt.1_5'UTR|ARMC4_uc001itz.2_Missense_Mutation_p.K304T|ARMC4_uc010qdu.1_5'UTR	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	304							binding			ovary(4)|skin(2)	6						TTCTGAAAATTTTGGTGATTT	0.294												
ERCC6	2074	broad.mit.edu	37	10	50681583	50681583	+	Silent	SNP	G	G	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr10:50681583G>C	uc001jhs.3	-	14	2803	c.2649C>G	c.(2647-2649)CTC>CTG	p.L883L	ERCC6_uc009xod.2_Silent_p.L43L|ERCC6_uc010qgr.1_Silent_p.L253L|ERCC6_uc001jhr.3_Silent_p.L251L	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	883	Helicase C-terminal.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						CATCCATCTTGAGATAGGTAT	0.433								Direct_reversal_of_damage|NER				
PCDH15	65217	broad.mit.edu	37	10	55581742	55581742	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr10:55581742A>C	uc001jju.1	-	33	6139	c.5744T>G	c.(5743-5745)CTT>CGT	p.L1915R	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Missense_Mutation_p.L769R|PCDH15_uc010qhv.1_Missense_Mutation_p.L1912R|PCDH15_uc010qhw.1_Missense_Mutation_p.L1875R|PCDH15_uc010qhx.1_Missense_Mutation_p.L1846R|PCDH15_uc010qhy.1_Missense_Mutation_p.L1922R|PCDH15_uc010qhz.1_Missense_Mutation_p.L1917R|PCDH15_uc010qia.1_Missense_Mutation_p.L1895R|PCDH15_uc010qib.1_Missense_Mutation_p.L1892R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1915	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CATAGTTTGAAGTTCTGAAAC	0.343										HNSCC(58;0.16)		
NRBF2	29982	broad.mit.edu	37	10	64913946	64913946	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr10:64913946G>A	uc001jmj.3	+	4	1056	c.832G>A	c.(832-834)GAG>AAG	p.E278K	NRBF2_uc010qip.1_Missense_Mutation_p.E268K	NM_030759	NP_110386	Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	278					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding				0	Prostate(12;0.0119)|all_hematologic(501;0.191)					GGAGCTCTCTGAGGATATTCT	0.393												
C10orf12	26148	broad.mit.edu	37	10	98742710	98742710	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr10:98742710A>G	uc001kmv.2	+	1	1670	c.1563A>G	c.(1561-1563)CTA>CTG	p.L521L		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	521										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		ACAGATGCCTAAGAAATCAGA	0.408												
CPXM2	119587	broad.mit.edu	37	10	125506356	125506356	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr10:125506356T>G	uc001lhk.1	-	14	2520	c.2195A>C	c.(2194-2196)AAG>ACG	p.K732T	CPXM2_uc001lhj.2_Intron	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	732					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CTTCCCAAACTTCTCCATGAT	0.582												
MUC5B	727897	broad.mit.edu	37	11	1284366	1284366	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:1284366C>G	uc009ycr.1	+	73	18549	c.18423C>G	c.(18421-18423)TTC>TTG	p.F6141L		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:Variant_position_missing_in_Q9HC84_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCGGGGCCTTCCCCACACCGG	0.652												
IGF2	3481	broad.mit.edu	37	11	2154862	2154862	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:2154862C>T	uc009yde.2	-	3	294	c.191G>A	c.(190-192)CGT>CAT	p.R64H	IGF2_uc001lvf.2_RNA|IGF2_uc001lvg.2_Missense_Mutation_p.R64H|IGF2_uc009ydf.2_Missense_Mutation_p.R120H|IGF2_uc001lvh.2_Missense_Mutation_p.R64H|INS-IGF2_uc001lvi.2_RNA	NM_001007139	NP_001007140	P01344	IGF2_HUMAN	insulin-like growth factor 2 isoform 1	64	C.				glucose metabolic process|ossification|phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling|positive regulation of activated T cell proliferation|positive regulation of cell division|positive regulation of glycogen (starch) synthase activity|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|skeletal system development	extracellular space	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|protein serine/threonine kinase activator activity|receptor activator activity			central_nervous_system(1)	1		all_epithelial(84;5.04e-06)|Breast(177;0.000777)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.0179)|COAD - Colon adenocarcinoma(6;0.029)	BRCA - Breast invasive adenocarcinoma(625;1.09e-05)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		AACGATGCCACGGCTGCGACG	0.657												
OR52A1	23538	broad.mit.edu	37	11	5172765	5172765	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:5172765A>G	uc010qyy.1	-	1	835	c.835T>C	c.(835-837)TTT>CTT	p.F279L		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	279	Helical; Name=7; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGCTAGAAAAGAGAATATGG	0.433												
HBD	3045	broad.mit.edu	37	11	5255610	5255610	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:5255610T>G	uc001maf.1	-	1	249	c.54A>C	c.(52-54)AAA>AAC	p.K18N		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	18					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCACGTTCACTTTGCCCCACA	0.502												
OR52N5	390075	broad.mit.edu	37	11	5799454	5799454	+	Nonsense_Mutation	SNP	G	G	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:5799454G>C	uc010qzn.1	-	1	411	c.411C>G	c.(409-411)TAC>TAG	p.Y137*	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AACGCAAAGGGTAGCAAATGG	0.507												
NAV2	89797	broad.mit.edu	37	11	20066813	20066813	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:20066813T>G	uc010rdm.1	+	15	3929	c.3568T>G	c.(3568-3570)TCA>GCA	p.S1190A	NAV2_uc001mpp.2_Missense_Mutation_p.S1103A|NAV2_uc001mpr.3_Missense_Mutation_p.S1167A|NAV2_uc001mpt.2_Missense_Mutation_p.S253A|NAV2_uc009yhx.2_Missense_Mutation_p.S253A|NAV2_uc009yhy.1_Missense_Mutation_p.S166A	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	1190						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						TGGTCGGAAGTCAAGTATGGA	0.557												
OR4A47	403253	broad.mit.edu	37	11	48510658	48510658	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:48510658T>C	uc010rhx.1	+	1	314	c.314T>C	c.(313-315)TTC>TCC	p.F105S		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAGCACATTTTCGGTGGGTCA	0.453												
OR5L2	26338	broad.mit.edu	37	11	55595086	55595086	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:55595086T>C	uc001nhy.1	+	1	392	c.392T>C	c.(391-393)CTG>CCG	p.L131P		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				AACCCCCTGCTGTACATGGTG	0.522										HNSCC(27;0.073)		
OR5L2	26338	broad.mit.edu	37	11	55595254	55595254	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:55595254T>G	uc001nhy.1	+	1	560	c.560T>G	c.(559-561)CTT>CGT	p.L187R		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CTCCTAAGTCTTGCTTGCTCT	0.453										HNSCC(27;0.073)		
CTNND1	1500	broad.mit.edu	37	11	57577603	57577603	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:57577603C>T	uc001nmc.3	+	16	3029	c.2458C>T	c.(2458-2460)CGA>TGA	p.R820*	CTNND1_uc001nlh.1_Nonsense_Mutation_p.R820*|CTNND1_uc001nlu.3_Nonsense_Mutation_p.R713*|CTNND1_uc001nlt.3_Nonsense_Mutation_p.R713*|CTNND1_uc001nls.3_Nonsense_Mutation_p.R713*|CTNND1_uc001nlw.3_Nonsense_Mutation_p.R713*|CTNND1_uc001nmf.3_Nonsense_Mutation_p.R820*|CTNND1_uc001nmd.3_Nonsense_Mutation_p.R766*|CTNND1_uc001nlk.3_Nonsense_Mutation_p.R766*|CTNND1_uc001nme.3_Nonsense_Mutation_p.R814*|CTNND1_uc001nll.3_Nonsense_Mutation_p.R760*|CTNND1_uc001nmg.3_Nonsense_Mutation_p.R760*|CTNND1_uc001nlj.3_Nonsense_Mutation_p.R760*|CTNND1_uc001nlr.3_Nonsense_Mutation_p.R760*|CTNND1_uc001nlp.3_Nonsense_Mutation_p.R760*|CTNND1_uc001nlx.3_Nonsense_Mutation_p.R497*|CTNND1_uc001nlz.3_Nonsense_Mutation_p.R497*|CTNND1_uc009ymn.2_Nonsense_Mutation_p.R491*|CTNND1_uc001nlm.3_Nonsense_Mutation_p.R814*|CTNND1_uc001nly.3_Nonsense_Mutation_p.R491*|CTNND1_uc001nmb.3_Nonsense_Mutation_p.R491*|CTNND1_uc001nma.3_Nonsense_Mutation_p.R491*|CTNND1_uc001nmi.3_Nonsense_Mutation_p.R719*|CTNND1_uc001nmh.3_Nonsense_Mutation_p.R814*|CTNND1_uc001nlq.3_Nonsense_Mutation_p.R719*|CTNND1_uc001nln.3_Nonsense_Mutation_p.R814*|CTNND1_uc001nli.3_Nonsense_Mutation_p.R814*|CTNND1_uc001nlo.3_Nonsense_Mutation_p.R713*|CTNND1_uc001nlv.3_Nonsense_Mutation_p.R713*	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	820	ARM 10.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				AAAAGAAGTTCGAGCAGCAGC	0.398												
MPEG1	219972	broad.mit.edu	37	11	58979956	58979956	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:58979956T>C	uc001nnu.3	-	1	539	c.383A>G	c.(382-384)AAG>AGG	p.K128R		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	128	MACPF.|Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				AGTGGAAAACTTGCCATTGAC	0.448												
MTA2	9219	broad.mit.edu	37	11	62365105	62365105	+	Silent	SNP	G	G	A	rs141754862		TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:62365105G>A	uc001ntq.1	-	7	951	c.570C>T	c.(568-570)ATC>ATT	p.I190I	MTA2_uc010rlx.1_Silent_p.I17I	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	190	ELM2.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GAAACTGGTCGATCTGCCGGT	0.542												
DDI1	414301	broad.mit.edu	37	11	103908695	103908695	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:103908695A>C	uc001phr.2	+	1	1388	c.1145A>C	c.(1144-1146)AAG>ACG	p.K382T	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	382					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TCTTCGGACAAGGAAATTACA	0.473												
ZNF259	8882	broad.mit.edu	37	11	116653713	116653713	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:116653713T>C	uc001ppp.2	-	11	1047	c.1014A>G	c.(1012-1014)CTA>CTG	p.L338L	ZNF259_uc009yzd.2_Silent_p.L338L|ZNF259_uc001ppq.2_Silent_p.L268L	NM_003904	NP_003895	O75312	ZPR1_HUMAN	zinc finger protein 259	338					cell proliferation|signal transduction	cytoplasm|nucleolus					0	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		GTTCAAATTCTAGCTCTGGGA	0.502												
ZNF259	8882	broad.mit.edu	37	11	116653717	116653717	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:116653717T>C	uc001ppp.2	-	11	1043	c.1010A>G	c.(1009-1011)GAG>GGG	p.E337G	ZNF259_uc009yzd.2_Missense_Mutation_p.E337G|ZNF259_uc001ppq.2_Missense_Mutation_p.E267G	NM_003904	NP_003895	O75312	ZPR1_HUMAN	zinc finger protein 259	337					cell proliferation|signal transduction	cytoplasm|nucleolus					0	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.61e-06)|all cancers(92;0.000139)|OV - Ovarian serous cystadenocarcinoma(223;0.153)		AAATTCTAGCTCTGGGATTTC	0.498												
DSCAML1	57453	broad.mit.edu	37	11	117332257	117332257	+	Silent	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:117332257G>A	uc001prh.1	-	18	3503	c.3501C>T	c.(3499-3501)GCC>GCT	p.A1167A		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1107	Fibronectin type-III 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGAGATGACGGCCACGTCAG	0.617												
OR4D5	219875	broad.mit.edu	37	11	123810958	123810958	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:123810958T>C	uc001pzk.1	+	1	635	c.635T>C	c.(634-636)CTG>CCG	p.L212P		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		ATGTGTTTTCTGGTGCTTCTG	0.522												
OR10G9	219870	broad.mit.edu	37	11	123894603	123894603	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:123894603A>C	uc010sad.1	+	1	884	c.884A>C	c.(883-885)AAG>ACG	p.K295T		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AAGGAGGTGAAGAAAGCTGTG	0.423												
ROBO4	54538	broad.mit.edu	37	11	124756666	124756666	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:124756666A>T	uc001qbg.2	-	16	2628	c.2488T>A	c.(2488-2490)TAC>AAC	p.Y830N	ROBO4_uc010sas.1_Missense_Mutation_p.Y685N|ROBO4_uc001qbh.2_3'UTR|ROBO4_uc001qbi.2_Missense_Mutation_p.Y388N	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	830					angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ACGCTGATGTACCCATAGGTG	0.622												
JAM3	83700	broad.mit.edu	37	11	134010576	134010576	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:134010576C>T	uc001qhb.1	+	3	326	c.302C>T	c.(301-303)ACG>ATG	p.T101M	JAM3_uc009zcz.1_Missense_Mutation_p.T101M	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	56	Extracellular (Potential).|Ig-like V-type.				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		TGCATCATTACGGATTCGCAG	0.448												
CLEC12A	160364	broad.mit.edu	37	12	10124213	10124213	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:10124213T>G	uc001qwr.3	+	1	206	c.18T>G	c.(16-18)ACT>ACG	p.T6T	CLEC12A_uc001qwq.2_Silent_p.T16T|CLEC12A_uc001qws.3_Silent_p.T6T|CLEC12A_uc001qwt.2_5'UTR	NM_138337	NP_612210	Q5QGZ9	CL12A_HUMAN	myeloid inhibitory C-type lectin-like receptor	6	Cytoplasmic (Potential).|ITIM motif.					integral to membrane|plasma membrane	receptor activity|sugar binding			skin(1)	1						AAGAAGTTACTTATGCAGATC	0.343												
GSG1	83445	broad.mit.edu	37	12	13240138	13240138	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:13240138A>C	uc001rbn.2	-	6	867	c.694T>G	c.(694-696)TTG>GTG	p.L232V	GSG1_uc001rbj.2_Missense_Mutation_p.L196V|GSG1_uc001rbk.2_Missense_Mutation_p.L237R|GSG1_uc001rbl.2_Missense_Mutation_p.L168V|GSG1_uc001rbm.2_Missense_Mutation_p.L145V|GSG1_uc001rbo.2_Missense_Mutation_p.L273R|GSG1_uc001rbp.2_Missense_Mutation_p.L209V|GSG1_uc001rbq.1_Missense_Mutation_p.L273R	NM_001080555	NP_001074024	Q2KHT4	GSG1_HUMAN	germ cell associated 1 isoform 4	219						endoplasmic reticulum membrane|integral to membrane					0		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		TCTGGACCCAAGTTGACAGTC	0.512												
RERG	85004	broad.mit.edu	37	12	15262280	15262280	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:15262280A>G	uc001rcs.2	-	4	504	c.364T>C	c.(364-366)TTG>CTG	p.L122L	RERG_uc001rct.2_Silent_p.L122L|RERG_uc010shu.1_Silent_p.L103L	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	122					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						GAGTGGTCCAAGTCAGCTTTG	0.483												
OVCH1	341350	broad.mit.edu	37	12	29644030	29644030	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:29644030T>G	uc001rix.1	-	5	550	c.550A>C	c.(550-552)ACA>CCA	p.T184P		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	184	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TGTCTCTTACTTTTGGAAATC	0.398												
NEUROD4	58158	broad.mit.edu	37	12	55420426	55420426	+	Missense_Mutation	SNP	A	A	G	rs76064726	by1000genomes	TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:55420426A>G	uc001sgp.3	+	2	581	c.203A>G	c.(202-204)AAG>AGG	p.K68R		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	68			K -> T.		amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						GAGAAACCTAAGAGAAGGGGT	0.433												
C12orf63	374467	broad.mit.edu	37	12	97085072	97085072	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:97085072T>G	uc001tet.1	+	11	1601	c.1523T>G	c.(1522-1524)GTT>GGT	p.V508G		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	508										skin(6)|ovary(1)	7						CTGCACTTTGTTAGGCAAAAC	0.333												
C12orf63	374467	broad.mit.edu	37	12	97158013	97158013	+	Silent	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:97158013A>C	uc001tet.1	+	26	3478	c.3400A>C	c.(3400-3402)AGA>CGA	p.R1134R		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1134										skin(6)|ovary(1)	7						GATTGCAATAAGAGCTGCTGC	0.343												
FAM71C	196472	broad.mit.edu	37	12	100043118	100043118	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:100043118T>G	uc001tgn.2	+	2	1090	c.668T>G	c.(667-669)CTT>CGT	p.L223R	ANKS1B_uc001tge.1_Intron|ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Intron	NM_153364	NP_699195	Q8NEG0	FA71C_HUMAN	hypothetical protein LOC196472	223											0				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)		ATCAGTAGACTTCACATGAAT	0.398												
BTBD11	121551	broad.mit.edu	37	12	108045467	108045467	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:108045467A>C	uc001tmk.1	+	16	3529	c.3008A>C	c.(3007-3009)AAG>ACG	p.K1003T	BTBD11_uc001tml.1_Missense_Mutation_p.K540T|BTBD11_uc001tmm.1_Missense_Mutation_p.K82T	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	1003						integral to membrane	DNA binding			skin(2)|ovary(1)	3						TCTGCTGCTAAGTTTTTCCAG	0.438												
CCDC63	160762	broad.mit.edu	37	12	111342574	111342574	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:111342574T>G	uc001trv.1	+	11	1720	c.1525T>G	c.(1525-1527)TTC>GTC	p.F509V	CCDC63_uc010sye.1_Missense_Mutation_p.F469V|CCDC63_uc001trw.1_Missense_Mutation_p.F424V	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	509										skin(6)|ovary(1)|pancreas(1)	8						GGCTGACCCCTTCAGCGACAG	0.597												
RBM19	9904	broad.mit.edu	37	12	114395629	114395629	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:114395629C>T	uc009zwi.2	-	6	942	c.798G>A	c.(796-798)GGG>GGA	p.G266G	RBM19_uc001tvn.3_Silent_p.G266G|RBM19_uc001tvm.2_Silent_p.G266G	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	266					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CAGCTGGCATCCCTTGCTCTT	0.627												
MED13L	23389	broad.mit.edu	37	12	116457702	116457702	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:116457702T>G	uc001tvw.2	-	6	756	c.701A>C	c.(700-702)AAG>ACG	p.K234T		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	234					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CTCAATCAACTTACGAGTGGC	0.443												
TMEM132D	121256	broad.mit.edu	37	12	129558890	129558890	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr12:129558890T>G	uc009zyl.1	-	9	3158	c.2830A>C	c.(2830-2832)AAA>CAA	p.K944Q	TMEM132D_uc001uia.2_Missense_Mutation_p.K482Q	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	944	Cytoplasmic (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGTCTGTATTTTAATGCAAAG	0.458												
TPTE2	93492	broad.mit.edu	37	13	20041386	20041386	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:20041386T>G	uc001umd.2	-	8	702	c.491A>C	c.(490-492)AAG>ACG	p.K164T	TPTE2_uc009zzk.2_Intron|TPTE2_uc009zzl.2_Intron|TPTE2_uc001ume.2_Intron|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	164	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CCTAAGCAACTTAATGTCAAA	0.303												
SACS	26278	broad.mit.edu	37	13	23908498	23908498	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:23908498A>C	uc001uon.2	-	10	10106	c.9517T>G	c.(9517-9519)TTT>GTT	p.F3173V	SACS_uc001uoo.2_Missense_Mutation_p.F3026V|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3173					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GTTGTTAGAAACTTGGGTCGT	0.328												
SACS	26278	broad.mit.edu	37	13	23908500	23908500	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:23908500T>G	uc001uon.2	-	10	10104	c.9515A>C	c.(9514-9516)AAG>ACG	p.K3172T	SACS_uc001uoo.2_Missense_Mutation_p.K3025T|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3172					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTTAGAAACTTGGGTCGTTT	0.323												
RNF17	56163	broad.mit.edu	37	13	25367370	25367370	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:25367370T>G	uc001upr.2	+	10	1167	c.1126T>G	c.(1126-1128)TTC>GTC	p.F376V	RNF17_uc010tdd.1_Missense_Mutation_p.F235V|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.F376V|RNF17_uc001ups.2_Missense_Mutation_p.F315V|RNF17_uc001upq.1_Missense_Mutation_p.F376V	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	376					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AGCAAAAAACTTCCAGCCACA	0.418												
ATP8A2	51761	broad.mit.edu	37	13	26436488	26436488	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:26436488T>C	uc001uqk.2	+	33	3267	c.3125T>C	c.(3124-3126)TTT>TCT	p.F1042S	ATP8A2_uc010tdi.1_Missense_Mutation_p.F977S|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.F592S	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	1002	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CTGGTGTTTTTTGGCATCTAC	0.517												
FLT1	2321	broad.mit.edu	37	13	28959121	28959121	+	Missense_Mutation	SNP	C	C	T	rs137937570		TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:28959121C>T	uc001usb.3	-	14	2302	c.2017G>A	c.(2017-2019)GCC>ACC	p.A673T	FLT1_uc010aar.1_Missense_Mutation_p.A673T	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	673	Ig-like C2-type 7.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTGCTGATGGCCACTGTGTGA	0.448												
NBEA	26960	broad.mit.edu	37	13	35758142	35758142	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:35758142A>G	uc001uvb.2	+	30	5067	c.4861A>G	c.(4861-4863)AGT>GGT	p.S1621G	NBEA_uc010abi.2_Intron	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1621						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CCCTCATCCAAGTTTGAACCA	0.443												
POSTN	10631	broad.mit.edu	37	13	38160293	38160293	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:38160293T>C	uc001uwo.3	-	7	996	c.878A>G	c.(877-879)GAC>GGC	p.D293G	POSTN_uc001uwp.3_Missense_Mutation_p.D293G|POSTN_uc001uwr.2_Missense_Mutation_p.D293G|POSTN_uc001uwq.2_Missense_Mutation_p.D293G|POSTN_uc010teu.1_Missense_Mutation_p.D293G|POSTN_uc010tev.1_Missense_Mutation_p.D293G|POSTN_uc010tew.1_Missense_Mutation_p.D293G|POSTN_uc010tex.1_Missense_Mutation_p.D208G	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	293	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AGCCACTTTGTCTCCCATGAT	0.453												
POSTN	10631	broad.mit.edu	37	13	38162024	38162024	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:38162024T>G	uc001uwo.3	-	5	659	c.541A>C	c.(541-543)AAT>CAT	p.N181H	POSTN_uc001uwp.3_Missense_Mutation_p.N181H|POSTN_uc001uwr.2_Missense_Mutation_p.N181H|POSTN_uc001uwq.2_Missense_Mutation_p.N181H|POSTN_uc010teu.1_Missense_Mutation_p.N181H|POSTN_uc010tev.1_Missense_Mutation_p.N181H|POSTN_uc010tew.1_Missense_Mutation_p.N181H|POSTN_uc010tex.1_Missense_Mutation_p.N96H	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	181	FAS1 1.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ATCATGCCATTTTTTAAGTCC	0.328												
LCP1	3936	broad.mit.edu	37	13	46732680	46732680	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:46732680A>C	uc001vaz.3	-	4	461	c.335T>G	c.(334-336)GTT>GGT	p.V112G	LCP1_uc001vba.3_Missense_Mutation_p.V112G	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	112	Actin-binding 1.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TTGGGTGCCAACGCTAGACTG	0.443			T	BCL6	NHL 							
C13orf18	80183	broad.mit.edu	37	13	46917551	46917551	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:46917551A>C	uc010acl.2	-	15	2563	c.1958T>G	c.(1957-1959)CTT>CGT	p.L653R	C13orf18_uc010tfy.1_Missense_Mutation_p.L176R|C13orf18_uc001vbf.3_Missense_Mutation_p.L586R|C13orf18_uc001vbg.3_Missense_Mutation_p.L381R|C13orf18_uc010tfz.1_Missense_Mutation_p.L496R|C13orf18_uc010acm.2_Missense_Mutation_p.L518R|C13orf18_uc010acn.2_Missense_Mutation_p.L438R|C13orf18_uc001vbe.3_Missense_Mutation_p.F602V|C13orf18_uc001vbh.3_Missense_Mutation_p.L653R|C13orf18_uc001vbi.3_Missense_Mutation_p.L496R	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	653											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		ACTTTCCAGAAGTTTTCTCCT	0.502												
HTR2A	3356	broad.mit.edu	37	13	47409690	47409690	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:47409690T>G	uc001vbq.2	-	3	832	c.698A>C	c.(697-699)AAC>ACC	p.N233T	HTR2A_uc001vbr.2_Missense_Mutation_p.N133T|HTR2A_uc010acr.2_Missense_Mutation_p.N233T	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	233	Extracellular (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CAGGACAAAGTTATCATCGGC	0.433												
UTP14C	9724	broad.mit.edu	37	13	52604528	52604528	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:52604528G>A	uc001vgb.2	+	2	2123	c.1588G>A	c.(1588-1590)GTG>ATG	p.V530M	UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	530					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TCCCAGACCTGTGTTAGAAGG	0.463												
EDNRB	1910	broad.mit.edu	37	13	78477428	78477428	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:78477428T>G	uc001vko.2	-	3	922	c.664A>C	c.(664-666)ATT>CTT	p.I222L	EDNRB_uc001vkq.1_Missense_Mutation_p.I222L|uc001vkn.1_Intron|EDNRB_uc010aez.1_Missense_Mutation_p.I222L|EDNRB_uc001vkp.1_Missense_Mutation_p.I305L	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	222	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	ATCAAAACAATTTCTACTGCT	0.383												
EDNRB	1910	broad.mit.edu	37	13	78492671	78492671	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:78492671A>C	uc001vko.2	-	1	296	c.38T>G	c.(37-39)GTT>GGT	p.V13G	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Missense_Mutation_p.V13G|EDNRB_uc010aez.1_Missense_Mutation_p.V13G|EDNRB_uc001vkp.1_Missense_Mutation_p.V96G|EDNRB_uc010afa.1_Missense_Mutation_p.V13G	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	13					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	AACCAGCGCAACCAGGGCGCG	0.637											OREG0022452	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
SLITRK5	26050	broad.mit.edu	37	13	88328833	88328833	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:88328833A>C	uc001vln.2	+	2	1409	c.1190A>C	c.(1189-1191)AAG>ACG	p.K397T	SLITRK5_uc010tic.1_Missense_Mutation_p.K156T	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	397	Extracellular (Potential).|LRRNT.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CAGGAGCGAAAGATCGAGAGC	0.537												
GPC6	10082	broad.mit.edu	37	13	94197663	94197663	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:94197663A>T	uc001vlt.2	+	2	940	c.308A>T	c.(307-309)AAG>ATG	p.K103M	GPC6_uc010tig.1_Missense_Mutation_p.K103M|GPC6_uc001vlu.1_Missense_Mutation_p.K33M	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	103						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				TCCAGGCATAAGAAATTTGAC	0.353												
GPC6	10082	broad.mit.edu	37	13	94680041	94680041	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr13:94680041G>C	uc001vlt.2	+	4	1402	c.770G>C	c.(769-771)TGT>TCT	p.C257S	GPC6_uc010tig.1_Missense_Mutation_p.C257S	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	257						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				TGCCCATACTGTCGGGGGCTT	0.498												
OR4K17	390436	broad.mit.edu	37	14	20586335	20586335	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr14:20586335A>G	uc001vwo.1	+	1	770	c.770A>G	c.(769-771)AAG>AGG	p.K257R		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ATAACCATTAAGAACCACTCT	0.418												
NOVA1	4857	broad.mit.edu	37	14	26917982	26917982	+	Missense_Mutation	SNP	A	A	C	rs144207941		TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr14:26917982A>C	uc001wpy.2	-	5	1025	c.707T>G	c.(706-708)CTT>CGT	p.L236R	NOVA1_uc001wpz.2_Missense_Mutation_p.L212R|NOVA1_uc001wqa.2_Missense_Mutation_p.L114R	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	239	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		CTGGATGATAAGTTCAACAGC	0.468												
AKAP6	9472	broad.mit.edu	37	14	33293936	33293936	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr14:33293936T>G	uc001wrq.2	+	13	7087	c.6917T>G	c.(6916-6918)CTT>CGT	p.L2306R		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2306					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAAGAAAATCTTCTAAACCTT	0.428												
TRIM9	114088	broad.mit.edu	37	14	51467557	51467557	+	Silent	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr14:51467557A>C	uc001wyx.3	-	6	2073	c.1308T>G	c.(1306-1308)GCT>GCG	p.A436A	TRIM9_uc001wyy.2_Intron|TRIM9_uc001wyz.3_Silent_p.A436A	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	436					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					CTGGAGAGGAAGCTAAACAGA	0.478												
PELI2	57161	broad.mit.edu	37	14	56755305	56755305	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr14:56755305C>T	uc001xch.2	+	4	746	c.460C>T	c.(460-462)CGG>TGG	p.R154W		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	154					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						TTACACAGCACGGATATTCGC	0.463												
ZFYVE26	23503	broad.mit.edu	37	14	68241785	68241785	+	Silent	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr14:68241785G>A	uc001xka.2	-	27	5407	c.5268C>T	c.(5266-5268)CCC>CCT	p.P1756P	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.P1756P	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1756					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GGAGGGTCTCGGGATCTGCAG	0.438												
RGS6	9628	broad.mit.edu	37	14	72944985	72944985	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr14:72944985T>G	uc001xna.3	+	12	1325	c.802T>G	c.(802-804)TTG>GTG	p.L268V	RGS6_uc010ttn.1_Missense_Mutation_p.L268V|RGS6_uc001xmx.3_Missense_Mutation_p.L268V|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.L268V|RGS6_uc010ttp.1_Missense_Mutation_p.L199V|RGS6_uc001xmz.1_Missense_Mutation_p.L129V	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	268	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		GATAACATTTTTGAACGCACA	0.353												
ATP10A	57194	broad.mit.edu	37	15	25958965	25958965	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr15:25958965A>C	uc010ayu.2	-	10	2306	c.2200T>G	c.(2200-2202)TTC>GTC	p.F734V		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	734	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		AGGAGCTCGAAGGTGAGCCTG	0.612												
MAPKBP1	23005	broad.mit.edu	37	15	42116181	42116181	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr15:42116181T>C	uc001zok.3	+	30	4439	c.4153T>C	c.(4153-4155)TTG>CTG	p.L1385L	MAPKBP1_uc001zoj.3_Silent_p.L1379L|MAPKBP1_uc010bcj.2_Silent_p.L886L|MAPKBP1_uc010bci.2_Intron|MAPKBP1_uc010udb.1_Silent_p.L1218L|MAPKBP1_uc010bck.2_Silent_p.L596L|MAPKBP1_uc010bcl.2_Silent_p.L886L	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	1385										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CCCTGAAAACTTGCAGCCCCC	0.637												
NEDD4	4734	broad.mit.edu	37	15	56152694	56152694	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr15:56152694A>C	uc002adj.2	-	7	2428	c.2128T>G	c.(2128-2130)TTG>GTG	p.L710V	NEDD4_uc002adl.2_Missense_Mutation_p.L291V|NEDD4_uc002adi.2_Missense_Mutation_p.L638V|NEDD4_uc010ugj.1_Missense_Mutation_p.L694V|NEDD4_uc010bfm.2_Missense_Mutation_p.L693V|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	710	Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		GGAACATCCAAGTTACTTGAC	0.443												
TM6SF1	53346	broad.mit.edu	37	15	83790679	83790679	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr15:83790679T>G	uc002bjp.2	+	5	514	c.405T>G	c.(403-405)ACT>ACG	p.T135T	TM6SF1_uc010bmq.2_Silent_p.T135T|TM6SF1_uc002bjq.2_Silent_p.T135T|TM6SF1_uc010bmr.2_Intron|TM6SF1_uc002bjr.2_5'UTR	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	135						integral to membrane				ovary(1)	1						ACAGGGAAACTTATAGAACCA	0.299												
ADAMTSL3	57188	broad.mit.edu	37	15	84582078	84582078	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr15:84582078T>G	uc002bjz.3	+	16	2159	c.1935T>G	c.(1933-1935)ACT>ACG	p.T645T	ADAMTSL3_uc010bmt.1_Silent_p.T645T|ADAMTSL3_uc010bmu.1_Silent_p.T645T	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	645						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			GTGAGACGACTTACGACTGGG	0.567												
ADAMTSL3	57188	broad.mit.edu	37	15	84651194	84651194	+	Silent	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr15:84651194A>C	uc002bjz.3	+	21	3038	c.2814A>C	c.(2812-2814)CGA>CGC	p.R938R	ADAMTSL3_uc010bmt.1_Silent_p.R938R|ADAMTSL3_uc010bmu.1_Silent_p.R938R	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	938	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCGTGCGACGATTCCAGAAAT	0.498												
AGBL1	123624	broad.mit.edu	37	15	87089239	87089239	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr15:87089239T>C	uc002blz.1	+	19	2634	c.2554T>C	c.(2554-2556)TGT>CGT	p.C852R		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	852					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GTAGGTTTTCTGTGACTTCCA	0.433												
CLDN9	9080	broad.mit.edu	37	16	3063438	3063438	+	Silent	SNP	C	C	T	rs137924866		TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr16:3063438C>T	uc010uwo.1	+	1	982	c.75C>T	c.(73-75)TGC>TGT	p.C25C		NM_020982	NP_066192	O95484	CLD9_HUMAN	claudin 9	25	Helical; (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TGGTGTCCTGCGCCCTGCCCC	0.652												
CREBBP	1387	broad.mit.edu	37	16	3779644	3779644	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr16:3779644C>T	uc002cvv.2	-	31	5608	c.5404G>A	c.(5404-5406)GTG>ATG	p.V1802M	CREBBP_uc002cvw.2_Missense_Mutation_p.V1764M	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1802	TAZ-type 2.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGTGCTGCACCACCCGCTTC	0.647			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome			
DNAH3	55567	broad.mit.edu	37	16	20998712	20998712	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr16:20998712C>T	uc010vbe.1	-	47	6941	c.6941G>A	c.(6940-6942)CGT>CAT	p.R2314H	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2314					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GTCAATCAGACGATCATAGAA	0.413												
NUP93	9688	broad.mit.edu	37	16	56832411	56832411	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr16:56832411C>T	uc002eka.2	+	4	442	c.321C>T	c.(319-321)GAC>GAT	p.D107D	NUP93_uc002ekb.2_5'UTR|NUP93_uc010vhi.1_5'UTR	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	107					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						ATGAGAAGGACAATGCCCTGC	0.358												
CCDC135	84229	broad.mit.edu	37	16	57760055	57760055	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr16:57760055G>A	uc002emi.2	+	13	1923	c.1834G>A	c.(1834-1836)GCG>ACG	p.A612T	CCDC135_uc002emj.2_Missense_Mutation_p.A612T|CCDC135_uc002emk.2_Missense_Mutation_p.A547T	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	612						cytoplasm				central_nervous_system(1)	1						GTTTCTGGTCGCGGAGGAGCG	0.632												
HYDIN	54768	broad.mit.edu	37	16	71015346	71015346	+	Silent	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr16:71015346G>A	uc002ezr.2	-	29	4583	c.4455C>T	c.(4453-4455)AGC>AGT	p.S1485S		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1486										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				TTCCCTCTCCGCTCAGAGTGA	0.478												
OR3A1	4994	broad.mit.edu	37	17	3195720	3195720	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:3195720A>C	uc002fvh.1	-	1	157	c.157T>G	c.(157-159)TTG>GTG	p.L53V		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						GGCTCCACCAAGACAGCTGCC	0.567												
NLRP1	22861	broad.mit.edu	37	17	5463142	5463142	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:5463142G>T	uc002gci.2	-	4	1429	c.874C>A	c.(874-876)CAA>AAA	p.Q292K	NLRP1_uc002gcg.1_Missense_Mutation_p.Q292K|NLRP1_uc002gck.2_Missense_Mutation_p.Q292K|NLRP1_uc002gcj.2_Missense_Mutation_p.Q292K|NLRP1_uc002gcl.2_Missense_Mutation_p.Q292K|NLRP1_uc002gch.3_Missense_Mutation_p.Q292K|NLRP1_uc010clh.2_Missense_Mutation_p.Q292K	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	292					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				AGGGGATCTTGGCTTCTGGGG	0.473												
C17orf59	54785	broad.mit.edu	37	17	8093038	8093038	+	Missense_Mutation	SNP	C	C	G	rs144247363	byFrequency	TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:8093038C>G	uc010vut.1	-	1	527	c.421G>C	c.(421-423)GAG>CAG	p.E141Q		NM_017622	NP_060092	Q96GS4	CQ059_HUMAN	hypothetical protein LOC54785	141											0						TCTTCCTCCTCCTGCTGCTCA	0.716												
GLP2R	9340	broad.mit.edu	37	17	9757876	9757876	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:9757876T>G	uc002gmd.1	+	5	569	c.569T>G	c.(568-570)CTT>CGT	p.L190R		NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	190	Helical; Name=1; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	TCCTTCTCTCTTATCTCCCTC	0.463												
DNAH9	1770	broad.mit.edu	37	17	11520913	11520913	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:11520913G>A	uc002gne.2	+	5	1158	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	364	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCTGCTCCAGGAGATTTGCAA	0.617												
DNAH9	1770	broad.mit.edu	37	17	11671828	11671828	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:11671828A>C	uc002gne.2	+	37	7297	c.7229A>C	c.(7228-7230)AAG>ACG	p.K2410T	DNAH9_uc010coo.2_Missense_Mutation_p.K1704T	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2410					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AAAACAGTCAAGTTTCCTTCC	0.498												
MYOCD	93649	broad.mit.edu	37	17	12655799	12655799	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:12655799G>T	uc002gnn.2	+	10	1493	c.1194G>T	c.(1192-1194)ATG>ATT	p.M398I	MYOCD_uc002gno.2_Missense_Mutation_p.M398I|MYOCD_uc002gnp.1_Missense_Mutation_p.M302I|MYOCD_uc002gnq.2_Missense_Mutation_p.M117I	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	398	SAP.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CGGCTCTCATGGACCGGCTTC	0.517												
C17orf42	79736	broad.mit.edu	37	17	29231427	29231427	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:29231427T>G	uc002hfu.2	-	2	222	c.152A>C	c.(151-153)GAT>GCT	p.D51A	C17orf42_uc002hfv.2_RNA|C17orf42_uc002hfw.2_Missense_Mutation_p.D51A|C17orf42_uc010wbs.1_Missense_Mutation_p.D51A	NM_024683	NP_078959	Q96QE5	TEFM_HUMAN	hypothetical protein LOC79736	51					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding			ovary(1)	1		all_cancers(10;4.64e-07)|all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				TGCATTTTCATCACAAAAAGT	0.423												
KIF2B	84643	broad.mit.edu	37	17	51902173	51902173	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:51902173A>T	uc002iua.2	+	1	1935	c.1779A>T	c.(1777-1779)AAA>AAT	p.K593N	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	593					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AGGAGCAGAAAGAGATTGAAG	0.418												
GH2	2689	broad.mit.edu	37	17	61957795	61957795	+	Silent	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr17:61957795G>A	uc002jco.1	-	5	602	c.540C>T	c.(538-540)GAC>GAT	p.D180D	GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_3'UTR|GH2_uc002jcm.1_Missense_Mutation_p.T179M|GH2_uc002jcn.1_Silent_p.D165D	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	180						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						TGAGCAGTGCGTCATCGTTGT	0.547												
CDH2	1000	broad.mit.edu	37	18	25565074	25565074	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr18:25565074A>C	uc002kwg.2	-	13	2558	c.2099T>G	c.(2098-2100)GTT>GGT	p.V700G	CDH2_uc010xbn.1_Missense_Mutation_p.V669G	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	700	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						ACACTGGCAAACCTTCACACG	0.483												
SETBP1	26040	broad.mit.edu	37	18	42532135	42532135	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr18:42532135A>C	uc010dni.2	+	4	3126	c.2830A>C	c.(2830-2832)AGC>CGC	p.S944R		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	944						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GAAACGGAAAAGCCTGCAAAA	0.512									Schinzel-Giedion_syndrome			
MYO5B	4645	broad.mit.edu	37	18	47488655	47488655	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr18:47488655A>C	uc002leb.2	-	12	1814	c.1526T>G	c.(1525-1527)CTG>CGG	p.L509R	MYO5B_uc002lec.1_Missense_Mutation_p.L508R	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	509	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TTCATCCAACAGGTCCAAGAT	0.393												
DCC	1630	broad.mit.edu	37	18	50961524	50961524	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr18:50961524A>G	uc002lfe.1	+	22	3761	c.3174A>G	c.(3172-3174)GGA>GGG	p.G1058G	DCC_uc010dpf.1_Silent_p.G693G	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1058	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTCGTCATGGAGATGGAGGTT	0.303												
SERPINB10	5273	broad.mit.edu	37	18	61597380	61597380	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr18:61597380T>G	uc010xev.1	+	6	682	c.592T>G	c.(592-594)TTA>GTA	p.L198V	SERPINB10_uc010xew.1_Missense_Mutation_p.L198V	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	198						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				ACATCAATTCTTAGTGCAAAA	0.383												
MUC16	94025	broad.mit.edu	37	19	9060081	9060081	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:9060081A>C	uc002mkp.2	-	3	27569	c.27365T>G	c.(27364-27366)CTT>CGT	p.L9122R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9124	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTACTCATAAGAGCGGTCAT	0.488												
MUC16	94025	broad.mit.edu	37	19	9061830	9061830	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:9061830A>C	uc002mkp.2	-	3	25820	c.25616T>G	c.(25615-25617)CTT>CGT	p.L8539R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8541	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTACTCATAAGAGTGGTCAT	0.522												
MUC16	94025	broad.mit.edu	37	19	9076366	9076366	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:9076366T>G	uc002mkp.2	-	3	11284	c.11080A>C	c.(11080-11082)AGT>CGT	p.S3694R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3695	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAGTCCAACTTGTACTTAAA	0.443												
MUC16	94025	broad.mit.edu	37	19	9086887	9086887	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:9086887A>G	uc002mkp.2	-	1	5132	c.4928T>C	c.(4927-4929)GTC>GCC	p.V1643A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1643	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCCCAGGGTGACTCCACTACT	0.507												
ZNF426	79088	broad.mit.edu	37	19	9639571	9639571	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:9639571T>G	uc002mlq.2	-	8	1414	c.1150A>C	c.(1150-1152)AGA>CGA	p.R384R	ZNF426_uc010dws.2_Silent_p.R346R	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	zinc finger protein 426	384	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTGTGAGTTCTTATATGTTGA	0.418												
CYP4F12	66002	broad.mit.edu	37	19	15795950	15795950	+	Missense_Mutation	SNP	G	G	A	rs150856722	by1000genomes	TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:15795950G>A	uc002nbl.2	+	9	1119	c.1058G>A	c.(1057-1059)CGC>CAC	p.R353H		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					TACCAGGAGCGCTGCCGACAG	0.572												
SIN3B	23309	broad.mit.edu	37	19	16942380	16942380	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:16942380C>T	uc002ney.1	+	3	317	c.303C>T	c.(301-303)AAC>AAT	p.N101N	SIN3B_uc002new.2_Silent_p.N101N|SIN3B_uc002nex.2_Silent_p.N33N|SIN3B_uc002nez.1_Silent_p.N101N	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	101	Interaction with REST (By similarity).|PAH 1.				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						TTGGATTCAACGCTTTTCTTC	0.493												
NCAN	1463	broad.mit.edu	37	19	19339180	19339180	+	Silent	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:19339180G>A	uc002nlz.2	+	8	2850	c.2751G>A	c.(2749-2751)CCG>CCA	p.P917P	NCAN_uc010ecc.1_Silent_p.P481P	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	917					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CAGTGCCTCCGCATCAGAGCA	0.617												
ZNF626	199777	broad.mit.edu	37	19	20808392	20808392	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:20808392T>G	uc002npb.1	-	4	441	c.291A>C	c.(289-291)AAA>AAC	p.K97N	ZNF626_uc002npc.1_Missense_Mutation_p.K21N	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCAGTACCACTTTTTGGAAAG	0.343												
ZNF43	7594	broad.mit.edu	37	19	21992583	21992583	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:21992583A>C	uc002nqj.2	-	4	386	c.256T>G	c.(256-258)TTT>GTT	p.F86V	ZNF43_uc010ecv.2_Missense_Mutation_p.F80V|ZNF43_uc002nql.2_Missense_Mutation_p.F80V|ZNF43_uc002nqm.2_Missense_Mutation_p.F80V|ZNF43_uc002nqk.2_Missense_Mutation_p.F16V	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	86					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TCTGGCCAAAAGTCTTGGGTA	0.279												
ZNF492	57615	broad.mit.edu	37	19	22846703	22846703	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:22846703A>C	uc002nqw.3	+	4	476	c.232A>C	c.(232-234)AAT>CAT	p.N78H		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	78					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TGGATGTGAAAATTTACAGTT	0.348												
ZNF260	339324	broad.mit.edu	37	19	37005915	37005915	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:37005915T>G	uc002oee.1	-	4	1070	c.226A>C	c.(226-228)AGT>CGT	p.S76R	ZNF260_uc002oed.1_Missense_Mutation_p.S73R|ZNF260_uc010eey.1_Missense_Mutation_p.S73R|ZNF260_uc002oef.1_Missense_Mutation_p.S73R	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	76	C2H2-type 2.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					CCTGTGTGACTTCTAAGGTGT	0.393												
ZNF568	374900	broad.mit.edu	37	19	37440630	37440630	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:37440630T>G	uc002ofc.2	+	7	1090	c.575T>G	c.(574-576)CTT>CGT	p.L192R	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.L116R|ZNF568_uc010efe.2_Missense_Mutation_p.L116R|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	192					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTAGACTTACTTAGATATGAG	0.363												
ZNF568	374900	broad.mit.edu	37	19	37441098	37441098	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:37441098A>C	uc002ofc.2	+	7	1558	c.1043A>C	c.(1042-1044)AAT>ACT	p.N348T	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.N272T|ZNF568_uc010efe.2_Missense_Mutation_p.N272T|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	348	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGAAGCAAAATCTTATTGAG	0.388												
ZNF607	84775	broad.mit.edu	37	19	38190535	38190535	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:38190535C>T	uc002ohc.1	-	5	1093	c.497G>A	c.(496-498)CGT>CAT	p.R166H	ZNF607_uc002ohb.1_Missense_Mutation_p.R165H	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			AGGTTTCTCACGAGCATTAAT	0.383												
CEACAM8	1088	broad.mit.edu	37	19	43097731	43097731	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:43097731A>T	uc002oud.2	-	2	488	c.386T>A	c.(385-387)CTT>CAT	p.L129H	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	129	Ig-like V-type.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				TTCACTCATAAGATTTAGCTT	0.478												
ZNF226	7769	broad.mit.edu	37	19	44679669	44679669	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:44679669A>T	uc002oyp.2	+	6	398	c.254A>T	c.(253-255)AAG>ATG	p.K85M	ZNF226_uc002oyq.2_Translation_Start_Site|ZNF226_uc002oyr.2_Translation_Start_Site|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.K85M|ZNF226_uc002oyt.2_Missense_Mutation_p.K85M	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AATCAAAGTAAGTTAATTACT	0.353												
SLC6A16	28968	broad.mit.edu	37	19	49814455	49814455	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:49814455T>C	uc002pmz.2	-	2	384	c.150A>G	c.(148-150)CAA>CAG	p.Q50Q	SLC6A16_uc002pna.2_Silent_p.Q50Q|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	50	Cytoplasmic (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		CTGCTGAAACTTGGGCCTCTG	0.547												
SYT3	84258	broad.mit.edu	37	19	51135733	51135733	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:51135733A>C	uc002pst.2	-	2	1118	c.484T>G	c.(484-486)TTG>GTG	p.L162V	SYT3_uc002psv.2_Missense_Mutation_p.L162V|SYT3_uc010ycd.1_Missense_Mutation_p.L162V	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	162	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		TCCATGTCCAAGTAGGAGGGC	0.657												
TSEN34	79042	broad.mit.edu	37	19	54696123	54696123	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:54696123C>T	uc002qdu.2	+	4	753	c.644C>T	c.(643-645)CCT>CTT	p.P215L	MBOAT7_uc002qdq.2_5'Flank|MBOAT7_uc002qdr.2_5'Flank|MBOAT7_uc002qds.2_5'Flank|MBOAT7_uc010yen.1_5'Flank|MBOAT7_uc002qdt.3_5'Flank|TSEN34_uc010yeo.1_Missense_Mutation_p.P215L|TSEN34_uc002qdv.2_Missense_Mutation_p.P215L|TSEN34_uc002qdw.2_Missense_Mutation_p.P215L	NM_024075	NP_076980	Q9BSV6	SEN34_HUMAN	tRNA-intron endonuclease 34	215					mRNA processing|tRNA-type intron splice site recognition and cleavage	nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity				0	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCCGGCCGCCCTGCCCACGAG	0.642												
ZNF667	63934	broad.mit.edu	37	19	56952809	56952809	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:56952809T>C	uc002qnd.2	-	5	1717	c.1555A>G	c.(1555-1557)AGA>GGA	p.R519G	ZNF667_uc010etl.2_Missense_Mutation_p.R301G|ZNF667_uc002qne.2_Missense_Mutation_p.R519G|ZNF667_uc010etm.2_Missense_Mutation_p.R462G	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	zinc finger protein 667	519	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GTGTGAATTCTTTCATGTTGG	0.438												
PEG3	5178	broad.mit.edu	37	19	57327880	57327880	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:57327880C>A	uc002qnu.2	-	7	2281	c.1930G>T	c.(1930-1932)GAA>TAA	p.E644*	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Nonsense_Mutation_p.E615*|PEG3_uc002qnv.2_Nonsense_Mutation_p.E644*|PEG3_uc002qnw.2_Nonsense_Mutation_p.E520*|PEG3_uc002qnx.2_Nonsense_Mutation_p.E518*|PEG3_uc010etr.2_Nonsense_Mutation_p.E644*	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	644	C2H2-type 4.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCTGATGTTCTTTCAGGGAT	0.418												
PEG3	5178	broad.mit.edu	37	19	57328104	57328104	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:57328104T>G	uc002qnu.2	-	7	2057	c.1706A>C	c.(1705-1707)AAG>ACG	p.K569T	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.K540T|PEG3_uc002qnv.2_Missense_Mutation_p.K569T|PEG3_uc002qnw.2_Missense_Mutation_p.K445T|PEG3_uc002qnx.2_Missense_Mutation_p.K443T|PEG3_uc010etr.2_Missense_Mutation_p.K569T	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	569	C2H2-type 3.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GAAGGTTTCCTTACACACCCT	0.368												
ZNF549	256051	broad.mit.edu	37	19	58048993	58048993	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:58048993A>G	uc002qpb.1	+	4	870	c.621A>G	c.(619-621)CAA>CAG	p.Q207Q	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Silent_p.Q194Q	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACAGCAGACAAGAGTATGCAC	0.438												
SNTG2	54221	broad.mit.edu	37	2	1271173	1271173	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:1271173T>G	uc002qwq.2	+	14	1242	c.1114T>G	c.(1114-1116)TTG>GTG	p.L372V	SNTG2_uc010ewi.2_Missense_Mutation_p.L245V	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	372	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GCAAGCAAACTTGTATCTGGG	0.522												
POMC	5443	broad.mit.edu	37	2	25384357	25384357	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:25384357G>A	uc002rfy.1	-	4	660	c.397C>T	c.(397-399)CGC>TGC	p.R133C	POMC_uc002rfz.1_Missense_Mutation_p.R133C|POMC_uc002rga.1_Missense_Mutation_p.R133C	NM_001035256	NP_001030333	P01189	COLI_HUMAN	proopiomelanocortin preproprotein	133					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	TTGCCCTCGCGCGGGCCCGGC	0.716												
C2orf39	92749	broad.mit.edu	37	2	26671585	26671585	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:26671585G>A	uc002rhg.2	+	11	1497	c.1423G>A	c.(1423-1425)GCG>ACG	p.A475T		NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	475											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAGGCCGCCGCGGAACCAGA	0.512												
GALNT14	79623	broad.mit.edu	37	2	31215824	31215824	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:31215824C>G	uc002rnr.2	-	2	798	c.179G>C	c.(178-180)CGG>CCG	p.R60P	GALNT14_uc002rnq.2_Missense_Mutation_p.R40P|GALNT14_uc002rns.2_Intron|GALNT14_uc010ymr.1_Missense_Mutation_p.R25P|GALNT14_uc010ezo.1_Missense_Mutation_p.R60P|GALNT14_uc010ezp.1_Missense_Mutation_p.R31P	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	60	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					ATTCAGATACCGCCGCTCATC	0.572												
MAP4K3	8491	broad.mit.edu	37	2	39664044	39664044	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:39664044C>T	uc002rro.2	-	1	176	c.85G>A	c.(85-87)GAC>AAC	p.D29N	MAP4K3_uc002rrp.2_Missense_Mutation_p.D29N|uc002rrq.2_Intron|uc002rrr.1_5'Flank	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	29	Protein kinase.|ATP (By similarity).				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TTGTAGACGTCGCCGTAGGTG	0.706												
SLC8A1	6546	broad.mit.edu	37	2	40656259	40656259	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:40656259T>G	uc002rrx.2	-	1	1186	c.1162A>C	c.(1162-1164)AGG>CGG	p.R388R	SLC8A1_uc002rry.2_Silent_p.R388R|SLC8A1_uc002rrz.2_Silent_p.R388R|SLC8A1_uc002rsa.2_Silent_p.R388R|SLC8A1_uc002rsd.3_Silent_p.R388R|SLC8A1_uc002rsb.1_Silent_p.R388R|SLC8A1_uc010fan.1_Silent_p.R388R|SLC8A1_uc002rsc.1_Silent_p.R388R	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	388	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACAGCCTTCCTTGCTTGGTCA	0.448												
SLC3A1	6519	broad.mit.edu	37	2	44531329	44531329	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:44531329T>C	uc002ruc.3	+	7	1262	c.1184T>C	c.(1183-1185)ATG>ACG	p.M395T	SLC3A1_uc002rtz.2_Missense_Mutation_p.M395T|SLC3A1_uc002rua.2_Missense_Mutation_p.M395T|SLC3A1_uc002rub.2_Missense_Mutation_p.M395T|SLC3A1_uc002rud.3_Missense_Mutation_p.M117T|SLC3A1_uc002rue.3_Missense_Mutation_p.M15T	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	395	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	AGGACCGTGATGTACTATGGA	0.458												
FSHR	2492	broad.mit.edu	37	2	49191058	49191058	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:49191058A>C	uc002rww.2	-	10	976	c.902T>G	c.(901-903)GTT>GGT	p.V301G	FSHR_uc002rwx.2_Missense_Mutation_p.V239G|FSHR_uc010fbn.2_Missense_Mutation_p.V275G	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	301	Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CATATAATCAACTTCTTGCCT	0.393									Gonadal_Dysgenesis_46_XX			
VPS54	51542	broad.mit.edu	37	2	64144075	64144075	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:64144075A>G	uc002scq.2	-	16	2350	c.2187T>C	c.(2185-2187)GCT>GCC	p.A729A	VPS54_uc002scp.2_Silent_p.A717A|VPS54_uc002scn.2_5'UTR|VPS54_uc002sco.2_Silent_p.A214A|VPS54_uc010fct.2_Silent_p.A576A	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	729					protein transport|retrograde transport, endosome to Golgi						0						TAAGAACTTCAGCTGGTTTCC	0.373												
CD207	50489	broad.mit.edu	37	2	71058947	71058947	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:71058947A>C	uc002shg.2	-	5	768	c.721T>G	c.(721-723)TTT>GTT	p.F241V		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	241	C-type lectin.|Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						TTATACAGAAACTCCTGTAGG	0.532												
CD207	50489	broad.mit.edu	37	2	71060118	71060118	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:71060118A>G	uc002shg.2	-	4	677	c.630T>C	c.(628-630)TCT>TCC	p.S210S		NM_015717	NP_056532	Q9UJ71	CLC4K_HUMAN	CD207 antigen, langerin	210	C-type lectin.|Extracellular (Potential).				defense response to virus	endocytic vesicle|integral to membrane	mannose binding			ovary(1)|lung(1)	2						TTGGAATGAGAGAAAAGTAAT	0.468												
EXOC6B	23233	broad.mit.edu	37	2	72606879	72606879	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:72606879A>C	uc010fep.2	-	19	2239	c.2101T>G	c.(2101-2103)TTG>GTG	p.L701V		NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	701					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						CTGACGTCCAAGTTGAACTGC	0.448												
ALMS1	7840	broad.mit.edu	37	2	73747132	73747132	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:73747132G>A	uc002sje.1	+	13	9884	c.9773G>A	c.(9772-9774)CGC>CAC	p.R3258H	ALMS1_uc002sjf.1_Missense_Mutation_p.R3214H|ALMS1_uc002sjg.2_Missense_Mutation_p.R2644H|ALMS1_uc002sjh.1_Missense_Mutation_p.R2644H|ALMS1_uc010fev.1_Missense_Mutation_p.R73H	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3256					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ACTTTTTCTCGCGGCACAGAT	0.408												
CNTNAP5	129684	broad.mit.edu	37	2	125530496	125530496	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:125530496A>T	uc002tno.2	+	17	3015	c.2651A>T	c.(2650-2652)AAG>ATG	p.K884M	CNTNAP5_uc010flu.2_Missense_Mutation_p.K885M	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	884	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGGAACCTCAAGGAGACCTCC	0.547												
THSD7B	80731	broad.mit.edu	37	2	137852673	137852673	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:137852673T>G	uc002tva.1	+	3	1088	c.1088T>G	c.(1087-1089)CTT>CGT	p.L363R	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.L253R	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GAAGGAGAACTTCTGCAGCAA	0.443												
THSD7B	80731	broad.mit.edu	37	2	138169270	138169270	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:138169270A>C	uc002tva.1	+	13	2694	c.2694A>C	c.(2692-2694)CAA>CAC	p.Q898H	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.Q788H	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTATATCCCAACCTTATGGAA	0.473												
LRP1B	53353	broad.mit.edu	37	2	141641403	141641403	+	Silent	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:141641403A>T	uc002tvj.1	-	25	5124	c.4152T>A	c.(4150-4152)GCT>GCA	p.A1384A	LRP1B_uc010fnl.1_Silent_p.A566A	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1384	Extracellular (Potential).|LDL-receptor class B 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGGGTCCAAAGCAATGGCCC	0.388										TSP Lung(27;0.18)		
XIRP2	129446	broad.mit.edu	37	2	168103841	168103841	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:168103841A>T	uc002udx.2	+	8	5957	c.5939A>T	c.(5938-5940)AAG>ATG	p.K1980M	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.K1805M|XIRP2_uc010fpq.2_Missense_Mutation_p.K1758M|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1805					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTTCAGCCAAAGCCAGGTCCA	0.468												
MYO3B	140469	broad.mit.edu	37	2	171242770	171242770	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:171242770T>G	uc002ufy.2	+	13	1505	c.1362T>G	c.(1360-1362)ACT>ACG	p.T454T	MYO3B_uc002ufv.2_Silent_p.T441T|MYO3B_uc010fqb.1_Silent_p.T441T|MYO3B_uc002ufz.2_Silent_p.T454T|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	454	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						AGCATTTGACTTTCTTGGGAA	0.443												
TTN	7273	broad.mit.edu	37	2	179415900	179415900	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:179415900T>G	uc010zfg.1	-	285	83878	c.83654A>C	c.(83653-83655)AAG>ACG	p.K27885T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K21580T|TTN_uc010zfi.1_Missense_Mutation_p.K21513T|TTN_uc010zfj.1_Missense_Mutation_p.K21388T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28812							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCCACAATCTTACTGCCTCC	0.458												
TTN	7273	broad.mit.edu	37	2	179578774	179578774	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:179578774T>G	uc010zfg.1	-	89	23103	c.22879A>C	c.(22879-22881)ACA>CCA	p.T7627P	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T4288P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8554							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTCACTTGTTAGCTCTTTT	0.428												
TTN	7273	broad.mit.edu	37	2	179613894	179613894	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:179613894T>C	uc002unb.2	-	46	13457	c.13233A>G	c.(13231-13233)CAA>CAG	p.Q4411Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGCACATTCTTGTACATTTT	0.313												
TTN	7273	broad.mit.edu	37	2	179616053	179616053	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:179616053T>G	uc002unb.2	-	46	11298	c.11074A>C	c.(11074-11076)AGT>CGT	p.S3692R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGGAAACTTTCACCTACA	0.338												
DNAH7	56171	broad.mit.edu	37	2	196771459	196771459	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:196771459A>C	uc002utj.3	-	27	4360	c.4259T>G	c.(4258-4260)CTT>CGT	p.L1420R		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1420	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGTGGGGTCAAGTTTTAGTTC	0.378												
MAP2	4133	broad.mit.edu	37	2	210561388	210561388	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:210561388A>G	uc002vde.1	+	8	4551	c.4303A>G	c.(4303-4305)AGA>GGA	p.R1435G	MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.R1431G	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1435					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TAAAACCGGGAGAGGCAGAAT	0.383												
ERBB4	2066	broad.mit.edu	37	2	212248599	212248599	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:212248599T>A	uc002veg.1	-	28	3766	c.3668A>T	c.(3667-3669)AAG>ATG	p.K1223M	ERBB4_uc002veh.1_Missense_Mutation_p.K1207M|ERBB4_uc010zji.1_Missense_Mutation_p.K1213M|ERBB4_uc010zjj.1_Missense_Mutation_p.K1197M	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1223	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TATGTTGTTCTTCAGGTACTC	0.517										TSP Lung(8;0.080)		
ERBB4	2066	broad.mit.edu	37	2	212426795	212426795	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:212426795T>C	uc002veg.1	-	20	2418	c.2320A>G	c.(2320-2322)AGT>GGT	p.S774G	ERBB4_uc002veh.1_Missense_Mutation_p.S774G|ERBB4_uc010zji.1_Missense_Mutation_p.S764G|ERBB4_uc010zjj.1_Missense_Mutation_p.S764G|ERBB4_uc010fut.1_Missense_Mutation_p.S774G	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	774	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TGATCCATACTTGCCATGATC	0.438										TSP Lung(8;0.080)		
ERBB4	2066	broad.mit.edu	37	2	212483974	212483974	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:212483974A>G	uc002veg.1	-	19	2327	c.2229T>C	c.(2227-2229)ACT>ACC	p.T743T	ERBB4_uc002veh.1_Silent_p.T743T|ERBB4_uc010zji.1_Silent_p.T733T|ERBB4_uc010zjj.1_Silent_p.T733T|ERBB4_uc010fut.1_Silent_p.T743T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	743	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GAATCTTCACAGTTTCTCCTT	0.373										TSP Lung(8;0.080)		
TMEM198	130612	broad.mit.edu	37	2	220409502	220409502	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:220409502A>G	uc002vme.2	+	3	638	c.53A>G	c.(52-54)GAT>GGT	p.D18G	CHPF_uc010zlh.1_5'Flank|CHPF_uc002vmc.3_5'Flank|CHPF_uc002vmd.3_5'Flank|TMEM198_uc002vmf.2_Missense_Mutation_p.D18G	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	18						integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CCTGAGCCAGATGATGCCTTC	0.597												
DOCK10	55619	broad.mit.edu	37	2	225702525	225702525	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:225702525T>A	uc010fwz.1	-	25	3043	c.2804A>T	c.(2803-2805)AAG>ATG	p.K935M	DOCK10_uc002vob.2_Missense_Mutation_p.K929M	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	935							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTCATGGCACTTGGCCACAAT	0.468												
KIAA1486	57624	broad.mit.edu	37	2	226447427	226447427	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:226447427A>G	uc002voe.2	+	4	1469	c.1294A>G	c.(1294-1296)AGT>GGT	p.S432G	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.S202G	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	432	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		CTACCCTAAAAGTCACTCCAC	0.667												
COL4A4	1286	broad.mit.edu	37	2	227953493	227953493	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:227953493C>A	uc010zlt.1	-	22	2153	c.1499G>T	c.(1498-1500)GGC>GTC	p.G500V		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	500	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GCCAGGGGGGCCCATGGGTCC	0.557												
SPHKAP	80309	broad.mit.edu	37	2	228886451	228886451	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:228886451T>C	uc002vpq.2	-	6	720	c.673A>G	c.(673-675)AGC>GGC	p.S225G	SPHKAP_uc002vpp.2_Missense_Mutation_p.S225G|SPHKAP_uc010zlx.1_Missense_Mutation_p.S225G	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	225						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCCACCTCGCTTTCCTCCTCC	0.438												
SLA2	84174	broad.mit.edu	37	20	35261962	35261962	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr20:35261962C>T	uc002xfv.2	-	4	624	c.262G>A	c.(262-264)GCC>ACC	p.A88T	SLA2_uc002xfu.2_Missense_Mutation_p.A88T	NM_032214	NP_115590	Q9H6Q3	SLAP2_HUMAN	Src-like-adaptor 2 isoform a	88	SH3.				antigen receptor-mediated signaling pathway|B cell mediated immunity|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|T cell activation	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	protein N-terminus binding|SH3/SH2 adaptor activity				0	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GAGACTTTGGCCACGTGGACG	0.597												
WISP2	8839	broad.mit.edu	37	20	43355923	43355923	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr20:43355923G>A	uc002xmn.2	+	5	1081	c.728G>A	c.(727-729)CGC>CAC	p.R243H	uc002xml.1_Intron|uc002xmm.1_Intron|WISP2_uc002xmp.2_Missense_Mutation_p.R243H|WISP2_uc002xmq.2_Missense_Mutation_p.A161T	NM_003881	NP_003872	O76076	WISP2_HUMAN	WNT1 inducible signaling pathway protein 2	243					cell adhesion|cell-cell signaling|signal transduction	extracellular region|soluble fraction	insulin-like growth factor binding			skin(1)	1		Myeloproliferative disorder(115;0.0122)				TCCAGGGGTCGCAGTCCACAA	0.682												
TMPRSS15	5651	broad.mit.edu	37	21	19687479	19687479	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr21:19687479T>G	uc002ykw.2	-	17	2047	c.2016A>C	c.(2014-2016)TCA>TCC	p.S672S		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	672	Extracellular (Potential).|LDL-receptor class A 2.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CTGCTTCATCTGAGCCATCCT	0.403												
ADAMTS1	9510	broad.mit.edu	37	21	28210864	28210864	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr21:28210864C>T	uc002ymf.2	-	8	2553	c.2098G>A	c.(2098-2100)GGT>AGT	p.G700S		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	700	Cys-rich.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		CGATCACAACCAGCTTTTACA	0.408												
ADAMTS1	9510	broad.mit.edu	37	21	28211926	28211926	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr21:28211926A>C	uc002ymf.2	-	7	2463	c.2008T>G	c.(2008-2010)TTC>GTC	p.F670V		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	670	Cys-rich.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		AAAACGAAGAAGTAGCCAATG	0.458												
POTEH	23784	broad.mit.edu	37	22	16287378	16287378	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr22:16287378A>G	uc010gqp.2	-	1	560	c.508T>C	c.(508-510)TAC>CAC	p.Y170H	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_5'UTR|POTEH_uc002zlj.1_Missense_Mutation_p.Y5H	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	170										skin(1)	1						CGGACGTGGTACCTCGGCTCC	0.582												
CYP2D6	1565	broad.mit.edu	37	22	42522680	42522680	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr22:42522680A>C	uc003bce.2	-	9	1480	c.1390T>G	c.(1390-1392)TTC>GTC	p.F464V	uc003bcd.1_Intron|CYP2D6_uc010gyu.2_Missense_Mutation_p.F158V|CYP2D6_uc003bcf.2_Missense_Mutation_p.F413V	NM_000106	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D,	464							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			breast(1)|skin(1)	2						GAGAAGCTGAAGTGCTGCAGC	0.662												
CELSR1	9620	broad.mit.edu	37	22	46859806	46859806	+	Silent	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr22:46859806G>A	uc003bhw.1	-	2	3981	c.3981C>T	c.(3979-3981)TCC>TCT	p.S1327S		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1327	Extracellular (Potential).|EGF-like 1; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GGAAGGGCGCGGAGCTGTCGA	0.667												
BRD1	23774	broad.mit.edu	37	22	50217634	50217634	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr22:50217634G>A	uc003biv.2	-	1	819	c.332C>T	c.(331-333)CCG>CTG	p.P111L	BRD1_uc011arf.1_5'UTR|BRD1_uc011arg.1_Missense_Mutation_p.P111L|BRD1_uc011arh.1_Missense_Mutation_p.P111L|BRD1_uc003biu.3_Missense_Mutation_p.P111L	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	111					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GGCCGAGGCCGGCGTGCCGTG	0.607												
GRM7	2917	broad.mit.edu	37	3	7456743	7456743	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:7456743A>C	uc003bqm.2	+	5	1341	c.1067A>C	c.(1066-1068)GAA>GCA	p.E356A	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.E356A|GRM7_uc003bql.2_Missense_Mutation_p.E356A|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	356	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CGTACACTTGAAAACAACAGA	0.403												
GRM7	2917	broad.mit.edu	37	3	7721845	7721845	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:7721845T>C	uc003bqm.2	+	9	2835	c.2561T>C	c.(2560-2562)CTC>CCC	p.L854P	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.L854P|GRM7_uc003bql.2_Missense_Mutation_p.L854P|GRM7_uc003bqn.1_Missense_Mutation_p.L437P	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	854	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CACCCTGAACTCAATGTCCAG	0.507												
OXSM	54995	broad.mit.edu	37	3	25833414	25833414	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:25833414A>C	uc003cdn.2	+	2	1010	c.903A>C	c.(901-903)GAA>GAC	p.E301D	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_Missense_Mutation_p.E26D|OXSM_uc010hfh.2_Intron	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	301					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						TCTATGCAGAAGTTTTGGGCT	0.463												
ARPP21	10777	broad.mit.edu	37	3	35778853	35778853	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:35778853A>G	uc003cgb.2	+	16	1907	c.1643A>G	c.(1642-1644)CAG>CGG	p.Q548R	ARPP21_uc003cga.2_Missense_Mutation_p.Q494R|ARPP21_uc011axy.1_Missense_Mutation_p.Q514R|ARPP21_uc003cgf.2_Missense_Mutation_p.Q349R|ARPP21_uc003cgg.2_Missense_Mutation_p.Q36R	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	548	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CTGGTCACTCAGGTAGGGGGC	0.602												
SCN10A	6336	broad.mit.edu	37	3	38739228	38739228	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:38739228T>G	uc003ciq.2	-	27	5483	c.5483A>C	c.(5482-5484)AAG>ACG	p.K1828T		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1828					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGCCATAAACTTCTCCTCCAT	0.433												
CNTN3	5067	broad.mit.edu	37	3	74350894	74350894	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:74350894A>G	uc003dpm.1	-	14	1929	c.1849T>C	c.(1849-1851)TCT>CCT	p.S617P		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	617	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TCTTTCCAAGAGAGTTGGGCT	0.453												
ROBO2	6092	broad.mit.edu	37	3	77530266	77530266	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:77530266T>C	uc003dpy.3	+	4	1206	c.563T>C	c.(562-564)CTG>CCG	p.L188P	ROBO2_uc003dpz.2_Missense_Mutation_p.L188P|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.L188P	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	188	Ig-like C2-type 2.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GGTGGAAAACTGATGATCTCC	0.313												
EPHA6	285220	broad.mit.edu	37	3	97356863	97356863	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:97356863A>C	uc010how.1	+	14	2764	c.2721A>C	c.(2719-2721)AAA>AAC	p.K907N	EPHA6_uc011bgp.1_3'UTR|EPHA6_uc003drs.3_Missense_Mutation_p.K299N|EPHA6_uc003drr.3_Missense_Mutation_p.K299N|EPHA6_uc003drt.2_Missense_Mutation_p.K299N|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	812	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.K813N(1)		stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TAGTATGCAAAGTTTCTGATT	0.403												
EPHA6	285220	broad.mit.edu	37	3	97454923	97454923	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:97454923A>C	uc010how.1	+	16	3132	c.3089A>C	c.(3088-3090)AAT>ACT	p.N1030T	EPHA6_uc003drt.2_Missense_Mutation_p.N422T|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	935	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CTGATCCGAAATCCCAGTGCC	0.443												
SI	6476	broad.mit.edu	37	3	164735642	164735642	+	Silent	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:164735642A>C	uc003fei.2	-	30	3602	c.3540T>G	c.(3538-3540)ACT>ACG	p.T1180T		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1180	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TTAGAGCAGGAGTTGGCTGGA	0.358										HNSCC(35;0.089)		
SI	6476	broad.mit.edu	37	3	164735779	164735779	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:164735779A>C	uc003fei.2	-	29	3561	c.3499T>G	c.(3499-3501)TTA>GTA	p.L1167V		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1167	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.L1167*(1)		ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTGTTGAGTAAGAAAACACCA	0.338										HNSCC(35;0.089)		
ZBBX	79740	broad.mit.edu	37	3	167034828	167034828	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:167034828G>A	uc003fep.2	-	14	1482	c.1159C>T	c.(1159-1161)CCT>TCT	p.P387S	ZBBX_uc011bpc.1_Missense_Mutation_p.P387S|ZBBX_uc003feq.2_Missense_Mutation_p.P358S	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	387						intracellular	zinc ion binding			ovary(2)	2						GATGGTTCAGGTCTCTCTATG	0.343												
KCNMB2	10242	broad.mit.edu	37	3	178560470	178560470	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr3:178560470T>G	uc003fjd.2	+	5	796	c.453T>G	c.(451-453)AAT>AAG	p.N151K	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Missense_Mutation_p.N151K|KCNMB2_uc003fjf.2_Missense_Mutation_p.N151K|KCNMB2_uc011bqa.1_Intron|KCNMB2_uc011bqb.1_RNA	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	151	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			GTGGAAAAAATTTTGAAGAAT	0.403												
ZNF718	255403	broad.mit.edu	37	4	154768	154768	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:154768T>G	uc003fzt.3	+	8	426	c.293T>G	c.(292-294)CTT>CGT	p.L98R	ZNF595_uc003fzu.1_Intron|ZNF718_uc010iaz.2_RNA|ZNF718_uc003fzw.3_5'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	98					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		TTCCACAAACTTATACCAAAA	0.338												
POLR2B	5431	broad.mit.edu	37	4	57860970	57860970	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:57860970T>A	uc003hcl.1	+	5	557	c.514T>A	c.(514-516)TGT>AGT	p.C172S	POLR2B_uc011cae.1_Missense_Mutation_p.C165S|POLR2B_uc011caf.1_Missense_Mutation_p.C97S	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	172					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					TCGTGATCTTTGTGAGTTAAA	0.333												
LPHN3	23284	broad.mit.edu	37	4	62812667	62812667	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:62812667T>C	uc010ihh.2	+	13	2424	c.2251T>C	c.(2251-2253)TTG>CTG	p.L751L	LPHN3_uc003hcq.3_Silent_p.L751L|LPHN3_uc003hct.2_Silent_p.L144L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	738	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GTATAACAACTTGGGTCCTTA	0.388												
PPEF2	5470	broad.mit.edu	37	4	76787343	76787343	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:76787343T>G	uc003hix.2	-	15	2276	c.1919A>C	c.(1918-1920)GAG>GCG	p.E640A	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_3'UTR	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	640					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CACCGTTACCTCGCGACTCAG	0.473												
BMP3	651	broad.mit.edu	37	4	81967513	81967513	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:81967513A>C	uc003hmg.3	+	2	1258	c.938A>C	c.(937-939)GAG>GCG	p.E313A		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	313					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						AAAAAGGATGAGGTGTGGGAG	0.512												
DSPP	1834	broad.mit.edu	37	4	88534300	88534300	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:88534300A>C	uc003hqu.2	+	4	1082	c.962A>C	c.(961-963)AAG>ACG	p.K321T		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	321					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		GATGGAGACAAGACCTCCAAG	0.418												
FAT4	79633	broad.mit.edu	37	4	126370822	126370822	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:126370822T>G	uc003ifj.3	+	9	8651	c.8651T>G	c.(8650-8652)CTT>CGT	p.L2884R	FAT4_uc011cgp.1_Missense_Mutation_p.L1182R|FAT4_uc003ifi.1_Missense_Mutation_p.L362R	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2884	Cadherin 28.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGCCCTGAACTTACTGAGATT	0.373												
DCHS2	54798	broad.mit.edu	37	4	155191053	155191053	+	Silent	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:155191053T>A	uc003inw.2	-	19	5211	c.5211A>T	c.(5209-5211)TCA>TCT	p.S1737S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1737	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AAGGATTACCTGACTTAGAGC	0.338												
RBM46	166863	broad.mit.edu	37	4	155720087	155720087	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:155720087A>C	uc003ioo.2	+	4	946	c.773A>C	c.(772-774)AAA>ACA	p.K258T	RBM46_uc011cim.1_Missense_Mutation_p.K258T|RBM46_uc003iop.1_Missense_Mutation_p.K258T	NM_144979	NP_659416	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	258	RRM 3.						nucleotide binding|RNA binding			central_nervous_system(1)|skin(1)	2	all_hematologic(180;0.24)	Renal(120;0.0854)				GAATTCAATAAATTTAAGCCT	0.363												
GUCY1A3	2982	broad.mit.edu	37	4	156629419	156629419	+	Missense_Mutation	SNP	A	A	C	rs142097871		TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:156629419A>C	uc003iov.2	+	6	885	c.349A>C	c.(349-351)ACA>CCA	p.T117P	GUCY1A3_uc003iou.2_Missense_Mutation_p.T117P|GUCY1A3_uc010iqc.2_Missense_Mutation_p.T117P|GUCY1A3_uc003iow.2_Missense_Mutation_p.T117P|GUCY1A3_uc010iqd.2_Missense_Mutation_p.T117P|GUCY1A3_uc003iox.2_Missense_Mutation_p.T117P|GUCY1A3_uc003ioz.2_5'UTR|GUCY1A3_uc003ioy.2_Missense_Mutation_p.T117P|GUCY1A3_uc010iqe.2_5'UTR|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.T117P	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	117					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CTTTGAAAAAACAATTGCAGA	0.279												
ODZ3	55714	broad.mit.edu	37	4	183664404	183664404	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:183664404G>A	uc003ivd.1	+	18	3498	c.3461G>A	c.(3460-3462)CGA>CAA	p.R1154Q	ODZ3_uc003ive.1_Missense_Mutation_p.R560Q	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1154	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GGCAATGGGCGAAGGCGCAGC	0.522												
TRIML2	205860	broad.mit.edu	37	4	189020226	189020226	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr4:189020226T>C	uc003izl.2	-	4	470	c.434A>G	c.(433-435)GAG>GGG	p.E145G	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.E195G|TRIML2_uc011clf.1_Missense_Mutation_p.E195G	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	145	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		ACACTTTTTCTCAAGCTCCAC	0.483												
SLC12A7	10723	broad.mit.edu	37	5	1083981	1083981	+	Silent	SNP	G	G	A	rs34815306	byFrequency	TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:1083981G>A	uc003jbu.2	-	8	1074	c.1008C>T	c.(1006-1008)TCC>TCT	p.S336S		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	336					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CCCAGAGCGCGGAGGTGGCTG	0.657												
SEMA5A	9037	broad.mit.edu	37	5	9197384	9197384	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:9197384A>G	uc003jek.2	-	10	1676	c.964T>C	c.(964-966)TTC>CTC	p.F322L		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	322	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CTCAGGTTGAAGACGCACACA	0.612												
DNAH5	1767	broad.mit.edu	37	5	13729585	13729585	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:13729585A>C	uc003jfd.2	-	69	11888	c.11846T>G	c.(11845-11847)CTT>CGT	p.L3949R	DNAH5_uc003jfc.2_Missense_Mutation_p.L117R	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3949					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GAGTTTGCTAAGTTCCACCAA	0.383									Kartagener_syndrome			
DNAH5	1767	broad.mit.edu	37	5	13769199	13769199	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:13769199T>G	uc003jfd.2	-	58	9809	c.9767A>C	c.(9766-9768)AAG>ACG	p.K3256T	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3256	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TACCTCAGCCTTGACCTTTTC	0.428									Kartagener_syndrome			
C5orf23	79614	broad.mit.edu	37	5	32789795	32789795	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:32789795T>G	uc003jhw.1	+	1	851	c.288T>G	c.(286-288)ACT>ACG	p.T96T		NM_024563	NP_078839			hypothetical protein LOC79614												0						AATGCATCACTTTCCTTTTAG	0.418												
SPEF2	79925	broad.mit.edu	37	5	35641550	35641550	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:35641550T>C	uc003jjo.2	+	3	290	c.179T>C	c.(178-180)CTT>CCT	p.L60P	SPEF2_uc003jjn.1_Missense_Mutation_p.L60P|SPEF2_uc003jjq.3_Missense_Mutation_p.L60P	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	60	CH.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTGCCAAACTTAATAATTTT	0.368												
C5orf42	65250	broad.mit.edu	37	5	37187931	37187931	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:37187931T>G	uc011cpa.1	-	22	4056	c.3825A>C	c.(3823-3825)GAA>GAC	p.E1275D	C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.E350D|C5orf42_uc011cpb.1_Missense_Mutation_p.E156D	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1275										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GAGCACAAAGTTCTCTGAAGC	0.348												
HTR1A	3350	broad.mit.edu	37	5	63257405	63257405	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:63257405A>C	uc011cqt.1	-	1	142	c.142T>G	c.(142-144)TTC>GTC	p.F48V		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	48	Helical; Name=1; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ACCGCGCAGAAGATGAGCGTG	0.602												
AGGF1	55109	broad.mit.edu	37	5	76358896	76358896	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:76358896G>A	uc003ket.2	+	14	2324	c.1964G>A	c.(1963-1965)CGA>CAA	p.R655Q		NM_018046	NP_060516	Q8N302	AGGF1_HUMAN	angiogenic factor VG5Q	655	G-patch.				angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		CAGCTTCGGCGAACACATGCA	0.443												
VCAN	1462	broad.mit.edu	37	5	82815417	82815417	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:82815417A>C	uc003kii.3	+	7	1648	c.1292A>C	c.(1291-1293)AAG>ACG	p.K431T	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.K431T|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	431	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGCAGTACCAAGAAGCCCTGG	0.448												
VCAN	1462	broad.mit.edu	37	5	82815448	82815448	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:82815448T>G	uc003kii.3	+	7	1679	c.1323T>G	c.(1321-1323)CCT>CCG	p.P441P	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Silent_p.P441P|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	441	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACTACTCACCTTCTGCTTCAG	0.473												
VCAN	1462	broad.mit.edu	37	5	82836092	82836092	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:82836092T>C	uc003kii.3	+	8	7626	c.7270T>C	c.(7270-7272)TTG>CTG	p.L2424L	VCAN_uc003kij.3_Silent_p.L1437L|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.L1088L	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2424	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ACCATCTGACTTGTATTATGA	0.393												
VCAN	1462	broad.mit.edu	37	5	82836790	82836790	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:82836790T>G	uc003kii.3	+	8	8324	c.7968T>G	c.(7966-7968)ACT>ACG	p.T2656T	VCAN_uc003kij.3_Silent_p.T1669T|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.T1320T	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2656	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AATCAATGACTTATGAAGATA	0.448												
SNCAIP	9627	broad.mit.edu	37	5	121787094	121787094	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:121787094A>C	uc003ksw.1	+	10	2758	c.2552A>C	c.(2551-2553)AAC>ACC	p.N851T	SNCAIP_uc011cwl.1_Missense_Mutation_p.N409T|SNCAIP_uc003ksx.1_Missense_Mutation_p.N898T|SNCAIP_uc003ksy.1_Missense_Mutation_p.N485T|SNCAIP_uc003ksz.1_Missense_Mutation_p.N485T|SNCAIP_uc010jcu.2_Missense_Mutation_p.N447T|SNCAIP_uc011cwm.1_Missense_Mutation_p.N485T|SNCAIP_uc003kta.1_Missense_Mutation_p.N483T|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.N545T|SNCAIP_uc010jcx.1_Missense_Mutation_p.N791T|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Missense_Mutation_p.N367T	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	851					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TCCACAAGTAACGAATCGGGG	0.478												
SLC27A6	28965	broad.mit.edu	37	5	128302234	128302234	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:128302234T>A	uc003kuy.2	+	2	800	c.404T>A	c.(403-405)CTC>CAC	p.L135H	SLC27A6_uc003kuz.2_Missense_Mutation_p.L135H	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	135	Helical; (Potential).				long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GTGGCCTTTCTCAACACCAAC	0.607												
PCDHA5	56143	broad.mit.edu	37	5	140203177	140203177	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:140203177T>C	uc003lhl.2	+	1	1817	c.1817T>C	c.(1816-1818)CTT>CCT	p.L606P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.L606P|PCDHA5_uc003lhj.1_Missense_Mutation_p.L606P	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	606	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGCTTGGCTTTCGTATGAG	0.662												
PCDHB3	56132	broad.mit.edu	37	5	140482134	140482134	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:140482134A>G	uc003lio.2	+	1	1901	c.1901A>G	c.(1900-1902)GAC>GGC	p.D634G	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	634	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCGAGCGCGACGCGGCCAAG	0.692												
PCDHGA3	56112	broad.mit.edu	37	5	140723787	140723787	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:140723787G>A	uc003ljm.1	+	1	187	c.187G>A	c.(187-189)GGA>AGA	p.G63R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Missense_Mutation_p.G63R	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	63	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGAGCGCGGAGTCCGCAT	0.607											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
SPINK5	11005	broad.mit.edu	37	5	147470754	147470754	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:147470754G>C	uc003lox.2	+	8	702	c.629G>C	c.(628-630)CGA>CCA	p.R210P	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Missense_Mutation_p.R182P|SPINK5_uc010jgr.2_Missense_Mutation_p.R191P|SPINK5_uc003low.2_Missense_Mutation_p.R210P|SPINK5_uc003loy.2_Missense_Mutation_p.R210P	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	210	Kazal-like 3.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGCCAAGCGAGAGGGTGAA	0.358												
FAT2	2196	broad.mit.edu	37	5	150925275	150925275	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:150925275A>G	uc003lue.3	-	9	5426	c.5413T>C	c.(5413-5415)TTG>CTG	p.L1805L	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1805	Extracellular (Potential).|Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCGGCTCCAAAATTTTATAG	0.408												
FAM114A2	10827	broad.mit.edu	37	5	153390808	153390808	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:153390808A>C	uc003lvb.2	-	9	1574	c.986T>G	c.(985-987)CTT>CGT	p.L329R	FAM114A2_uc003lvc.2_Missense_Mutation_p.L329R|FAM114A2_uc003lvd.2_Missense_Mutation_p.L329R|FAM114A2_uc003lve.2_Missense_Mutation_p.L145R|FAM114A2_uc011dda.1_Missense_Mutation_p.L259R	NM_018691	NP_061161	Q9NRY5	F1142_HUMAN	hypothetical protein LOC10827	329							purine nucleotide binding				0						TACCCTGGCAAGTTTCTCTGG	0.378												
FAM71B	153745	broad.mit.edu	37	5	156590352	156590352	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr5:156590352T>G	uc003lwn.2	-	2	1024	c.924A>C	c.(922-924)CAA>CAC	p.Q308H		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	308	Ala-rich.					nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGTGGTCACTTGACCTGGGC	0.512												
F13A1	2162	broad.mit.edu	37	6	6145969	6145969	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:6145969T>G	uc003mwv.2	-	15	2205	c.2082A>C	c.(2080-2082)GAA>GAC	p.E694D	F13A1_uc011dib.1_Missense_Mutation_p.K588T	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	694					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GCCGGCACACTTCTTCCCACT	0.537												
SYCP2L	221711	broad.mit.edu	37	6	10903119	10903119	+	Silent	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:10903119T>C	uc003mzo.2	+	8	860	c.564T>C	c.(562-564)ACT>ACC	p.T188T	SYCP2L_uc011din.1_Silent_p.T29T|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	188						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GCTTGAAGACTTTTAACTGCA	0.378												
DCDC2	51473	broad.mit.edu	37	6	24291223	24291223	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:24291223T>G	uc003ndx.2	-	5	943	c.641A>C	c.(640-642)AAG>ACG	p.K214T	DCDC2_uc003ndy.2_Missense_Mutation_p.K214T	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	214	Doublecortin 2.				cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				TTTCTTAAACTTATCTCTGCC	0.403												
BTN2A2	10385	broad.mit.edu	37	6	26388372	26388372	+	Missense_Mutation	SNP	G	G	A	rs144410497	byFrequency	TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:26388372G>A	uc003nhq.2	+	4	660	c.574G>A	c.(574-576)GCC>ACC	p.A192T	BTN2A2_uc011dkf.1_Missense_Mutation_p.A76T|BTN2A2_uc011dkg.1_Intron|BTN2A2_uc003nhr.2_Missense_Mutation_p.A76T|BTN2A2_uc011dkh.1_Intron|BTN2A2_uc003nhs.2_Missense_Mutation_p.A192T|BTN2A2_uc003nht.2_Missense_Mutation_p.A192T|BTN2A2_uc011dki.1_5'Flank	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	192	Extracellular (Potential).|Ig-like C2-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						GGTTGTGCCCGCCCTGAAGGA	0.577												
OR2J3	442186	broad.mit.edu	37	6	29080491	29080491	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:29080491A>C	uc011dll.1	+	1	824	c.824A>C	c.(823-825)AAG>ACG	p.K275T		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	275	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATCAAGGCAAGTTCATTGCC	0.438												
C6orf47	57827	broad.mit.edu	37	6	31627482	31627482	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:31627482C>T	uc003nvm.1	-	1	1068	c.243G>A	c.(241-243)GAG>GAA	p.E81E		NM_021184	NP_067007	O95873	CF047_HUMAN	G4 protein	81										ovary(1)	1						TCCCTAGCTGCTCAACTTGGG	0.562												
COL19A1	1310	broad.mit.edu	37	6	70745826	70745826	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:70745826T>G	uc003pfc.1	+	14	1282	c.1165T>G	c.(1165-1167)TTA>GTA	p.L389V	COL19A1_uc010kam.1_Missense_Mutation_p.L285V	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	389	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						ACCACCAGCCTTACCTGTAAG	0.303												
COQ3	51805	broad.mit.edu	37	6	99819343	99819343	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:99819343A>C	uc003ppk.2	-	6	877	c.850T>G	c.(850-852)TTT>GTT	p.F284V		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	284					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		GGTGAAACAAACTTCTCCCAT	0.353												
RGS17	26575	broad.mit.edu	37	6	153347643	153347643	+	Missense_Mutation	SNP	G	G	A	rs34438717		TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr6:153347643G>A	uc003qpm.2	-	3	311	c.155C>T	c.(154-156)GCG>GTG	p.A52V		NM_012419	NP_036551	Q9UGC6	RGS17_HUMAN	regulator of G-protein signalling 17	52					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			pancreas(1)	1		Ovarian(120;0.126)		OV - Ovarian serous cystadenocarcinoma(155;1.09e-09)|BRCA - Breast invasive adenocarcinoma(81;0.0429)		GGGTCTTCCCGCATTTTCCCC	0.388									Lung_Cancer_Familial_Clustering_of			
GPNMB	10457	broad.mit.edu	37	7	23292999	23292999	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:23292999T>G	uc003swc.2	+	2	305	c.144T>G	c.(142-144)TCT>TCG	p.S48S	GPNMB_uc003swa.2_Silent_p.S48S|GPNMB_uc003swb.2_Silent_p.S48S|GPNMB_uc011jyy.1_Silent_p.S48S|GPNMB_uc011jyz.1_Intron	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	48	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			ATGGCTGGTCTTCTGATGAAA	0.418												
BBS9	27241	broad.mit.edu	37	7	33397593	33397593	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:33397593T>G	uc003tdn.1	+	16	2192	c.1679T>G	c.(1678-1680)CTT>CGT	p.L560R	BBS9_uc003tdo.1_Missense_Mutation_p.L525R|BBS9_uc003tdp.1_Missense_Mutation_p.L555R|BBS9_uc003tdq.1_Missense_Mutation_p.L520R|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.L84R|BBS9_uc003tds.1_5'UTR|BBS9_uc011kao.1_Missense_Mutation_p.L438R	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	560					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GTCAGTCTTCTTAGTCTCTTC	0.388									Bardet-Biedl_syndrome			
GLI3	2737	broad.mit.edu	37	7	42006192	42006192	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:42006192G>T	uc011kbh.1	-	15	2570	c.2479C>A	c.(2479-2481)CTC>ATC	p.L827I	GLI3_uc011kbg.1_Missense_Mutation_p.L768I	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	827					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CTGCCCGGGAGAAGCGTCATG	0.587									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
ZNF117	51351	broad.mit.edu	37	7	64439906	64439906	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:64439906A>G	uc003ttr.2	-	4	1328	c.43T>C	c.(43-45)TAT>CAT	p.Y15H		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	15						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				GCAAAATAATAAAACATAACT	0.323												
WBSCR17	64409	broad.mit.edu	37	7	70597831	70597831	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:70597831T>G	uc003tvy.2	+	1	43	c.43T>G	c.(43-45)TTG>GTG	p.L15V		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	15	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGTGTTGAACTTGATCGCGGT	0.687												
PCLO	27445	broad.mit.edu	37	7	82544559	82544559	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:82544559T>G	uc003uhx.2	-	7	13032	c.12743A>C	c.(12742-12744)AAT>ACT	p.N4248T	PCLO_uc003uhv.2_Missense_Mutation_p.N4248T|PCLO_uc010lec.2_Missense_Mutation_p.N1213T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4179					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTCTGTAATATTTTTTCTGAG	0.428												
PCLO	27445	broad.mit.edu	37	7	82545733	82545733	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:82545733T>G	uc003uhx.2	-	7	11858	c.11569A>C	c.(11569-11571)AGA>CGA	p.R3857R	PCLO_uc003uhv.2_Silent_p.R3857R|PCLO_uc010lec.2_Silent_p.R822R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3788					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GGAGCAGTTCTTGGTCGCTCA	0.468												
PLOD3	8985	broad.mit.edu	37	7	100853686	100853686	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:100853686G>A	uc003uyd.2	-	14	1996	c.1540C>T	c.(1540-1542)CGG>TGG	p.R514W	PLOD3_uc010lhs.2_Missense_Mutation_p.R79W	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	514					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	GCCAGGAGCCGGCCAAATTCA	0.637												
IMMP2L	83943	broad.mit.edu	37	7	110526690	110526690	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:110526690C>G	uc003vfq.1	-	5	810	c.367G>C	c.(367-369)GAT>CAT	p.D123H	IMMP2L_uc010ljr.1_Missense_Mutation_p.D123H	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	123					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		CCATGATGATCACCTTCAACC	0.398												
RBM33	155435	broad.mit.edu	37	7	155537721	155537721	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:155537721G>A	uc010lqk.1	+	14	2772	c.2404G>A	c.(2404-2406)GAA>AAA	p.E802K	RBM33_uc011kvv.1_Missense_Mutation_p.E611K|RBM33_uc003wmg.2_5'Flank	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	802	Potential.						nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		ACGCCTAAGAGAAGAAATCCT	0.463												
WDR60	55112	broad.mit.edu	37	7	158695154	158695154	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:158695154C>A	uc003woe.3	+	10	1383	c.1225C>A	c.(1225-1227)CCT>ACT	p.P409T	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_5'UTR	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	409										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		GGAAGAACTTCCTCTAGCTCA	0.363												
CSMD1	64478	broad.mit.edu	37	8	3265708	3265708	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:3265708A>C	uc011kwk.1	-	14	2177	c.1787T>G	c.(1786-1788)ATT>AGT	p.I596S	CSMD1_uc011kwj.1_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	596	Extracellular (Potential).|CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGGTGACAGAATAATCCCAGA	0.368												
SGCZ	137868	broad.mit.edu	37	8	13959935	13959935	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:13959935A>C	uc003wwq.2	-	7	1354	c.694T>G	c.(694-696)TTC>GTC	p.F232V	SGCZ_uc010lss.2_Missense_Mutation_p.F185V	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	219	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GTGGCCTTGAAGTCTCCTGCA	0.512												
TUSC3	7991	broad.mit.edu	37	8	15480646	15480646	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:15480646T>A	uc003wwt.2	+	2	406	c.196T>A	c.(196-198)TTC>ATC	p.F66I	TUSC3_uc003wwr.2_Missense_Mutation_p.F66I|TUSC3_uc003wws.2_Missense_Mutation_p.F66I|TUSC3_uc003wwu.2_Missense_Mutation_p.F66I|TUSC3_uc003wwv.2_Missense_Mutation_p.F66I|TUSC3_uc003www.2_Missense_Mutation_p.F66I|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.F66I	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	66					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		ACGCTCAATCTTCCGAATGAA	0.388												
TUSC3	7991	broad.mit.edu	37	8	15605922	15605922	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:15605922T>C	uc003wwt.2	+	9	1186	c.976T>C	c.(976-978)TTC>CTC	p.F326L	TUSC3_uc003wwu.2_Missense_Mutation_p.F326L|TUSC3_uc003wwv.2_Missense_Mutation_p.F326L|TUSC3_uc003www.2_Intron|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Intron	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	326	Helical; (Potential).				cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		GGTCTTCTTCTTCAGTTTTCT	0.323												
RP1	6101	broad.mit.edu	37	8	55537320	55537320	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:55537320C>G	uc003xsd.1	+	4	1026	c.878C>G	c.(877-879)TCT>TGT	p.S293C	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	293					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTAGACTATTCTTTTGTTCCT	0.299												
RP1	6101	broad.mit.edu	37	8	55542278	55542278	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:55542278T>A	uc003xsd.1	+	4	5984	c.5836T>A	c.(5836-5838)TTC>ATC	p.F1946I	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1946					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATTGAAAATTTCTTGGGTTT	0.343												
TRPA1	8989	broad.mit.edu	37	8	72951153	72951153	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:72951153A>G	uc003xza.2	-	19	2417	c.2242T>C	c.(2242-2244)TCA>CCA	p.S748P	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	748	Extracellular (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	ATGCCAGTTGAGTTGAAAGCC	0.318												
CRISPLD1	83690	broad.mit.edu	37	8	75924709	75924709	+	Silent	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:75924709T>A	uc003yan.2	+	3	675	c.300T>A	c.(298-300)GCT>GCA	p.A100A	CRISPLD1_uc011lfk.1_5'UTR|CRISPLD1_uc011lfl.1_5'UTR	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	100						extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			AATCCTGGGCTGAAAGTTGCT	0.438												
DCAF4L2	138009	broad.mit.edu	37	8	88885921	88885921	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:88885921T>G	uc003ydz.2	-	1	376	c.279A>C	c.(277-279)GAA>GAC	p.E93D		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	93										ovary(1)	1						AGCCTCCAGCTTCGACTTGGT	0.547												
MMP16	4325	broad.mit.edu	37	8	89131066	89131066	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:89131066A>C	uc003yeb.3	-	5	1016	c.734T>G	c.(733-735)GTC>GGC	p.V245G	MMP16_uc003yec.2_Missense_Mutation_p.V245G	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	245	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						CAGTTCATGGACTGCTACAAG	0.373												
MMP16	4325	broad.mit.edu	37	8	89339369	89339369	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:89339369A>C	uc003yeb.3	-	1	349	c.67T>G	c.(67-69)TTG>GTG	p.L23V	MMP16_uc003yec.2_Missense_Mutation_p.L23V	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	23					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						AAGGTTTGCAAGAAAAACACC	0.493												
PGCP	10404	broad.mit.edu	37	8	97797501	97797501	+	Silent	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:97797501A>C	uc003yhw.2	+	2	542	c.376A>C	c.(376-378)AGA>CGA	p.R126R	PGCP_uc010mbe.2_Silent_p.R126R	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	126					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GCTGGAGCCAAGAATTCATAA	0.463												
UBR5	51366	broad.mit.edu	37	8	103357767	103357767	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:103357767A>C	uc003ykr.1	-	8	776	c.743T>G	c.(742-744)CTT>CGT	p.L248R	UBR5_uc003yks.1_Missense_Mutation_p.L248R	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	248					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GAGAGACATAAGATCCTCTAT	0.383												
DPYS	1807	broad.mit.edu	37	8	105436539	105436539	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:105436539T>C	uc003yly.3	-	7	1300	c.1171A>G	c.(1171-1173)AGA>GGA	p.R391G		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	391					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTCCTTTTCTTGGATAGAGA	0.373												
TRHR	7201	broad.mit.edu	37	8	110100172	110100172	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:110100172A>T	uc003ymz.3	+	1	447	c.431A>T	c.(430-432)AAG>ATG	p.K144M		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	144	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			AGAGCCAAAAAGATTATCATC	0.408												
PKHD1L1	93035	broad.mit.edu	37	8	110445390	110445390	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:110445390T>G	uc003yne.2	+	28	3389	c.3285T>G	c.(3283-3285)AGT>AGG	p.S1095R		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1095	Extracellular (Potential).|IPT/TIG 4.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTCTCCTAGTTCAGCTGTAA	0.338										HNSCC(38;0.096)		
CSMD3	114788	broad.mit.edu	37	8	113304877	113304877	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:113304877A>G	uc003ynu.2	-	55	8836	c.8677T>C	c.(8677-8679)TTT>CTT	p.F2893L	CSMD3_uc003yns.2_Missense_Mutation_p.F2095L|CSMD3_uc003ynt.2_Missense_Mutation_p.F2853L|CSMD3_uc011lhx.1_Missense_Mutation_p.F2724L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2893	Extracellular (Potential).|Sushi 19.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACATCATTAAAGTTGAACCCA	0.468										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CSMD3	114788	broad.mit.edu	37	8	113348960	113348960	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:113348960T>C	uc003ynu.2	-	44	7099	c.6940A>G	c.(6940-6942)AGA>GGA	p.R2314G	CSMD3_uc003yns.2_Missense_Mutation_p.R1516G|CSMD3_uc003ynt.2_Missense_Mutation_p.R2274G|CSMD3_uc011lhx.1_Missense_Mutation_p.R2210G|CSMD3_uc003ynw.1_Missense_Mutation_p.R25G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2314	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGGGGTACTCTTACAAGCCAA	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CSMD3	114788	broad.mit.edu	37	8	113933896	113933896	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:113933896T>A	uc003ynu.2	-	10	1752	c.1593A>T	c.(1591-1593)GAA>GAT	p.E531D	CSMD3_uc003ynt.2_Missense_Mutation_p.E491D|CSMD3_uc011lhx.1_Missense_Mutation_p.E427D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	531	Extracellular (Potential).|Sushi 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAGCAAAAACTTCAGCTATCC	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
TRPS1	7227	broad.mit.edu	37	8	116631822	116631822	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:116631822T>G	uc003ynz.2	-	2	923	c.464A>C	c.(463-465)AAG>ACG	p.K155T	TRPS1_uc011lhy.1_Missense_Mutation_p.K159T|TRPS1_uc003yny.2_Missense_Mutation_p.K168T|TRPS1_uc010mcy.2_Missense_Mutation_p.K155T	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	155					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TGGTGACATCTTCTGATCTTC	0.517									Langer-Giedion_syndrome			
HAS2	3037	broad.mit.edu	37	8	122626941	122626941	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:122626941T>G	uc003yph.2	-	4	1605	c.1067A>C	c.(1066-1068)AAG>ACG	p.K356T		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	356	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GAAGTAGGACTTGCTCCAACG	0.438												
TG	7038	broad.mit.edu	37	8	133912519	133912519	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:133912519G>A	uc003ytw.2	+	15	3409	c.3368G>A	c.(3367-3369)GGC>GAC	p.G1123D	TG_uc010mdw.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1123	Thyroglobulin type-1 9.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCGGGGGCTGGCACCTGGTGT	0.617												
ST3GAL1	6482	broad.mit.edu	37	8	134477158	134477158	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:134477158C>T	uc003yuk.2	-	7	1375	c.546G>A	c.(544-546)GGG>GGA	p.G182G	ST3GAL1_uc003yum.2_Silent_p.G182G	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	182	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			TGGTCTTGGTCCCAACATCAG	0.567												
CYP11B1	1584	broad.mit.edu	37	8	143956698	143956698	+	Silent	SNP	T	T	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:143956698T>A	uc003yxi.2	-	7	1159	c.1152A>T	c.(1150-1152)CGA>CGT	p.R384R	CYP11B1_uc010mex.2_Silent_p.R83R|CYP11B1_uc003yxh.2_Silent_p.R100R|CYP11B1_uc003yxj.2_Silent_p.R384R|CYP11B1_uc010mey.2_Silent_p.R455R	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	384					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	AGCTCGCCACTCGCTCCAGAA	0.607									Familial_Hyperaldosteronism_type_I			
PTPRD	5789	broad.mit.edu	37	9	8436611	8436611	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:8436611T>G	uc003zkk.2	-	34	4778	c.4067A>C	c.(4066-4068)AAG>ACG	p.K1356T	PTPRD_uc003zkp.2_Missense_Mutation_p.K950T|PTPRD_uc003zkq.2_Missense_Mutation_p.K949T|PTPRD_uc003zkr.2_Missense_Mutation_p.K940T|PTPRD_uc003zks.2_Missense_Mutation_p.K949T|PTPRD_uc003zkl.2_Missense_Mutation_p.K1347T|PTPRD_uc003zkm.2_Missense_Mutation_p.K1343T|PTPRD_uc003zkn.2_Missense_Mutation_p.K945T|PTPRD_uc003zko.2_Missense_Mutation_p.K946T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1356	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTGGGAAAACTTCAAGTTGTC	0.338										TSP Lung(15;0.13)		
ADAMTSL1	92949	broad.mit.edu	37	9	18776993	18776993	+	Silent	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:18776993G>A	uc003zne.3	+	19	2893	c.2766G>A	c.(2764-2766)ACG>ACA	p.T922T		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	922	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TCAGCTCGACGCACGTCACGG	0.692												
MAMDC2	256691	broad.mit.edu	37	9	72783642	72783642	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:72783642A>T	uc004ahm.2	+	10	2046	c.1429A>T	c.(1429-1431)AGT>TGT	p.S477C	MAMDC2_uc004ahn.2_RNA|uc004aho.1_Intron	NM_153267	NP_694999	Q7Z304	MAMC2_HUMAN	MAM domain containing 2 precursor	477	MAM 3.					endoplasmic reticulum|membrane				central_nervous_system(1)|pancreas(1)	2						CCTATGCAAAAGTTTCTGGGA	0.398												
GRIN3A	116443	broad.mit.edu	37	9	104433163	104433163	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:104433163T>G	uc004bbp.1	-	3	2132	c.1531A>C	c.(1531-1533)AGT>CGT	p.S511R	GRIN3A_uc004bbq.1_Missense_Mutation_p.S511R	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	511	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TGTAGCTTACTTGGATGTTGG	0.522												
SVEP1	79987	broad.mit.edu	37	9	113276307	113276307	+	Silent	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:113276307G>A	uc010mtz.2	-	4	1381	c.1044C>T	c.(1042-1044)CAC>CAT	p.H348H	SVEP1_uc010mua.1_Silent_p.H348H|SVEP1_uc004beu.2_Silent_p.H348H|SVEP1_uc004bev.2_Silent_p.H92H	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	348					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GTGGAGAGGTGTGATTTTCAT	0.512												
C9orf43	257169	broad.mit.edu	37	9	116191605	116191605	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:116191605T>G	uc004bho.3	+	14	1721	c.1325T>G	c.(1324-1326)CTT>CGT	p.L442R	C9orf43_uc004bhp.2_Missense_Mutation_p.L442R	NM_152786	NP_689999	Q8TAL5	CI043_HUMAN	hypothetical protein LOC257169	442											0						CTCAAACTACTTAGGATTCTT	0.517												
DBC1	1620	broad.mit.edu	37	9	121929578	121929578	+	Silent	SNP	C	C	T	rs141113114		TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:121929578C>T	uc004bkc.2	-	8	2526	c.2070G>A	c.(2068-2070)TCG>TCA	p.S690S		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	690					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GCATCACTGACGAAGAGGAAT	0.572												
TTLL11	158135	broad.mit.edu	37	9	124751548	124751548	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:124751548C>T	uc004blt.1	-	4	1653	c.1465G>A	c.(1465-1467)GCG>ACG	p.A489T	TTLL11_uc011lyl.1_Missense_Mutation_p.A489T|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Missense_Mutation_p.A166T|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	489	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						GGAGTCAGCGCGATGACCGTC	0.542												
TTLL11	158135	broad.mit.edu	37	9	124751858	124751858	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:124751858C>G	uc004blt.1	-	4	1343	c.1155G>C	c.(1153-1155)AAG>AAC	p.K385N	TTLL11_uc011lyl.1_Missense_Mutation_p.K385N|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Missense_Mutation_p.K62N|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	385	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						GAATATCAAACTTGAGCTTGT	0.493												
SLC27A4	10999	broad.mit.edu	37	9	131117714	131117714	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr9:131117714C>A	uc004but.2	+	11	1784	c.1500C>A	c.(1498-1500)TAC>TAA	p.Y500*	SLC27A4_uc004buu.2_Nonsense_Mutation_p.Y94*	NM_005094	NP_005085	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid	500					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding				0						GCTACCTGTACTTCCGAGACC	0.642												
MXRA5	25878	broad.mit.edu	37	X	3240515	3240515	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:3240515T>G	uc004crg.3	-	5	3368	c.3211A>C	c.(3211-3213)AAT>CAT	p.N1071H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1071						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCTAGCATATTTCCTCCCTGT	0.458												
NLGN4X	57502	broad.mit.edu	37	X	5821156	5821156	+	Silent	SNP	G	G	A	rs144614029		TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:5821156G>A	uc010ndh.2	-	5	2064	c.1563C>T	c.(1561-1563)GCC>GCT	p.A521A	NLGN4X_uc004crp.2_Silent_p.A541A|NLGN4X_uc004crq.2_Silent_p.A521A|NLGN4X_uc010ndi.2_Silent_p.A558A|NLGN4X_uc004crr.2_Silent_p.A521A|NLGN4X_uc010ndj.2_Silent_p.A521A	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	521	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TCATGACCACGGCGCTGAGCA	0.512												
NLGN4X	57502	broad.mit.edu	37	X	6069148	6069148	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:6069148C>T	uc010ndh.2	-	2	861	c.360G>A	c.(358-360)CTG>CTA	p.L120L	NLGN4X_uc004crp.2_Silent_p.L120L|NLGN4X_uc004crq.2_Silent_p.L120L|NLGN4X_uc010ndi.2_Silent_p.L120L|NLGN4X_uc004crr.2_Silent_p.L120L|NLGN4X_uc010ndj.2_Silent_p.L120L	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	120	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GCATGTCATGCAGTAAGGATC	0.493												
NLGN4X	57502	broad.mit.edu	37	X	6069402	6069402	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:6069402A>C	uc010ndh.2	-	2	607	c.106T>G	c.(106-108)TTC>GTC	p.F36V	NLGN4X_uc004crp.2_Missense_Mutation_p.F36V|NLGN4X_uc004crq.2_Missense_Mutation_p.F36V|NLGN4X_uc010ndi.2_Missense_Mutation_p.F36V|NLGN4X_uc004crr.2_Missense_Mutation_p.F36V|NLGN4X_uc010ndj.2_Missense_Mutation_p.F36V	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	36					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						ATGAGGGTGAACTTGATGGCA	0.502												
FAM9A	171482	broad.mit.edu	37	X	8763146	8763146	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:8763146T>G	uc004csg.2	-	7	915	c.804A>C	c.(802-804)GAA>GAC	p.E268D		NM_174951	NP_777611	Q8IZU1	FAM9A_HUMAN	family with sequence similarity 9, member A	268	Glu-rich.					nucleolus					0		Hepatocellular(5;0.219)				cctcttcttcttcttcctctt	0.129												
MOSPD2	158747	broad.mit.edu	37	X	14913459	14913459	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:14913459T>G	uc004cwi.2	+	4	353	c.265T>G	c.(265-267)TTA>GTA	p.L89V	MOSPD2_uc004cwj.2_Missense_Mutation_p.L26V	NM_152581	NP_689794	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	89	CRAL-TRIO.					integral to membrane	structural molecule activity			lung(1)	1	Hepatocellular(33;0.183)					TCCCAGATGGTTATTGGAAAT	0.299												
CXorf36	79742	broad.mit.edu	37	X	45060041	45060041	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:45060041C>T	uc004dgg.2	-	1	106	c.31G>A	c.(31-33)GCC>ACC	p.A11T	CXorf36_uc004dgi.3_Missense_Mutation_p.A11T	NM_176819	NP_789789	Q9H7Y0	CX036_HUMAN	hypothetical protein LOC79742 isoform 1	11						extracellular region				lung(1)	1						GGGCGGAGGGCGGCAGCCTCA	0.652												
ZNF182	7569	broad.mit.edu	37	X	47836329	47836329	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:47836329T>G	uc004dir.2	-	7	1503	c.1157A>C	c.(1156-1158)AAG>ACG	p.K386T	ZNF182_uc004dis.2_Missense_Mutation_p.K367T|ZNF182_uc004dit.2_Missense_Mutation_p.K386T|ZNF182_uc011mlu.1_Missense_Mutation_p.K366T	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	386	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						GAGAGTTGACTTATCACTGAA	0.368												
SUV39H1	6839	broad.mit.edu	37	X	48559088	48559088	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:48559088G>A	uc004dkn.2	+	3	817	c.772G>A	c.(772-774)GTC>ATC	p.V258I	SUV39H1_uc011mmf.1_Missense_Mutation_p.V269I|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	258	Mediates interaction with MECOM (By similarity).|SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						TGGCTGGGGCGTCCGCACCCT	0.602												
CCNB3	85417	broad.mit.edu	37	X	50090646	50090646	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:50090646A>G	uc004dox.3	+	11	4130	c.3832A>G	c.(3832-3834)ACA>GCA	p.T1278A	CCNB3_uc004doy.2_Missense_Mutation_p.T1278A|CCNB3_uc004doz.2_Missense_Mutation_p.T174A|CCNB3_uc010njq.2_Missense_Mutation_p.T170A|CCNB3_uc004dpa.2_Missense_Mutation_p.T117A	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1278					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CAACATGAAGACACTGACCTT	0.498												
PHF8	23133	broad.mit.edu	37	X	54037563	54037563	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:54037563A>G	uc004dsu.2	-	8	1119	c.1046T>C	c.(1045-1047)ATT>ACT	p.I349T	PHF8_uc004dst.2_Missense_Mutation_p.I313T|PHF8_uc004dsv.2_Missense_Mutation_p.I179T|PHF8_uc004dsw.2_Missense_Mutation_p.I313T|PHF8_uc004dsx.2_Missense_Mutation_p.I77T|PHF8_uc004dsy.2_Missense_Mutation_p.I313T	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	349	JmjC.				brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						ACCTGTGGGAATGAAAAGTGT	0.507												
GNL3L	54552	broad.mit.edu	37	X	54578117	54578117	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:54578117A>C	uc004dth.1	+	11	1119	c.980A>C	c.(979-981)AAG>ACG	p.K327T	GNL3L_uc004dti.2_RNA	NM_019067	NP_061940	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3	327					ribosome biogenesis	nucleolus	GTP binding			ovary(1)	1						CACGTGCAGAAGCTGGCAGAC	0.617												
ITIH5L	347365	broad.mit.edu	37	X	54783779	54783779	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:54783779T>C	uc004dtj.2	-	8	2758	c.2728A>G	c.(2728-2730)AGT>GGT	p.S910G		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	910	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						CCTGTGGAACTTGAGATTGTA	0.557												
ITIH5L	347365	broad.mit.edu	37	X	54783936	54783936	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:54783936T>G	uc004dtj.2	-	8	2601	c.2571A>C	c.(2569-2571)AAA>AAC	p.K857N		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	857	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GGGCACTCGGTTTAAGAGATA	0.517												
TRO	7216	broad.mit.edu	37	X	54951444	54951444	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:54951444A>G	uc004dtq.2	+	6	1535	c.1428A>G	c.(1426-1428)CAA>CAG	p.Q476Q	TRO_uc004dts.2_Silent_p.Q476Q|TRO_uc004dtr.2_Silent_p.Q476Q|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_RNA|TRO_uc004dtv.2_Silent_p.Q79Q|TRO_uc011mok.1_Silent_p.Q7Q|TRO_uc004dtw.2_Silent_p.Q79Q|TRO_uc004dtx.2_5'UTR	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	476	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						ATGTCATCCAAGAATATGATG	0.517												
APEX2	27301	broad.mit.edu	37	X	55033430	55033430	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:55033430A>G	uc004dtz.2	+	6	1195	c.1119A>G	c.(1117-1119)CAA>CAG	p.Q373Q	APEX2_uc011mom.1_Silent_p.Q202Q	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	373					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						ACAAAGCCCAAGTGCGCTCAA	0.547								Other_BER_factors				
FAM123B	139285	broad.mit.edu	37	X	63411809	63411809	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:63411809A>G	uc004dvo.2	-	2	1631	c.1358T>C	c.(1357-1359)CTT>CCT	p.L453P		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	453					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						AGGAGTCAAAAGTTCCCCAGG	0.532												
PJA1	64219	broad.mit.edu	37	X	68381908	68381908	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:68381908T>C	uc004dxh.2	-	2	1460	c.1174A>G	c.(1174-1176)AGC>GGC	p.S392G	PJA1_uc011mpi.1_Missense_Mutation_p.S110G|PJA1_uc004dxg.2_Missense_Mutation_p.S204G|PJA1_uc004dxi.2_Missense_Mutation_p.S337G	NM_145119	NP_660095	Q8NG27	PJA1_HUMAN	praja 1 isoform a	392							zinc ion binding				0						GTCTCCCAGCTTTCGCCACTG	0.587												
TAF1	6872	broad.mit.edu	37	X	70598122	70598122	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:70598122A>T	uc004dzu.3	+	7	1019	c.968A>T	c.(967-969)CAA>CTA	p.Q323L	BCYRN1_uc011mpt.1_Intron|TAF1_uc004dzt.3_Missense_Mutation_p.Q344L	NM_138923	NP_620278	P21675	TAF1_HUMAN	TBP-associated factor 1 isoform 2	323	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			ovary(7)|breast(4)|large_intestine(2)|central_nervous_system(2)|lung(1)|skin(1)	17	Renal(35;0.156)	all_lung(315;0.000321)				AAATTTTCCCAATCAACTGGA	0.468												
PGK1	5230	broad.mit.edu	37	X	77380399	77380399	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:77380399A>G	uc004ecz.3	+	9	1137	c.965A>G	c.(964-966)AAG>AGG	p.K322R	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Missense_Mutation_p.K294R	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	322					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						GAAAGCAGCAAGAAGTATGCT	0.507												
P2RY10	27334	broad.mit.edu	37	X	78216571	78216571	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:78216571T>C	uc004ede.2	+	4	923	c.554T>C	c.(553-555)CTT>CCT	p.L185P	P2RY10_uc004edf.2_Missense_Mutation_p.L185P	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	185	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						TTTGCTGATCTTGGATACAAG	0.478												
CHM	1121	broad.mit.edu	37	X	85211343	85211343	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:85211343T>G	uc004eet.2	-	8	1011	c.981A>C	c.(979-981)CAA>CAC	p.Q327H	CHM_uc011mqz.1_Missense_Mutation_p.Q179H	NM_000390	NP_000381	P24386	RAE1_HUMAN	choroideremia isoform a	327					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(1)	1		all_lung(315;5.41e-06)				GGGTTAATTTTTGAGTCTTTA	0.328												
PABPC5	140886	broad.mit.edu	37	X	90691203	90691203	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:90691203C>T	uc004efg.2	+	2	1067	c.627C>T	c.(625-627)GAC>GAT	p.D209D	PABPC5_uc004eff.1_Silent_p.D45D	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	209	RRM 3.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						TTGGAGACGACATAGATGACG	0.423												
PCDH19	57526	broad.mit.edu	37	X	99663303	99663303	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:99663303T>C	uc010nmz.2	-	1	1969	c.293A>G	c.(292-294)AAG>AGG	p.K98R	PCDH19_uc004efw.3_Missense_Mutation_p.K98R|PCDH19_uc004efx.3_Missense_Mutation_p.K98R	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	98	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						GATGATGCACTTGGGGCTCTG	0.557												
ZMAT1	84460	broad.mit.edu	37	X	101139416	101139416	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:101139416T>C	uc004eim.2	-	2	3968	c.470A>G	c.(469-471)AAG>AGG	p.K157R	ZMAT1_uc011mrl.1_Missense_Mutation_p.K328R|ZMAT1_uc004ein.2_Missense_Mutation_p.K157R|ZMAT1_uc011mrm.1_Missense_Mutation_p.K157R	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	157						nucleus	zinc ion binding			ovary(1)	1						CTCTCTCATCTTTCTGAAACA	0.403												
PSMD10	5716	broad.mit.edu	37	X	107331217	107331217	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:107331217G>A	uc004enp.1	-	3	424	c.326C>T	c.(325-327)CCC>CTC	p.P109L	PSMD10_uc004enq.1_Missense_Mutation_p.P109L|PSMD10_uc010nph.1_Intron	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	109	ANK 4.|Interaction with RELA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						ATAATGTAAGGGAGTACAGCC	0.438												
ALG13	79868	broad.mit.edu	37	X	110951264	110951264	+	Silent	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:110951264T>G	uc011msy.1	+	4	427	c.393T>G	c.(391-393)ACT>ACG	p.T131T	ALG13_uc011msw.1_Silent_p.T53T|ALG13_uc011msx.1_Silent_p.T27T|ALG13_uc011msz.1_Silent_p.T53T|ALG13_uc011mta.1_Silent_p.T27T|ALG13_uc011mtb.1_Silent_p.T27T			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	131					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						GGGTCCTGACTTGTCCTGGGC	0.522												
ZCCHC16	340595	broad.mit.edu	37	X	111698541	111698541	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:111698541A>C	uc004epo.1	+	3	1026	c.585A>C	c.(583-585)GAA>GAC	p.E195D		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	195							nucleic acid binding|zinc ion binding			ovary(1)	1						ACCAGGATGAAGAGAGTGTCA	0.468												
IL13RA2	3598	broad.mit.edu	37	X	114238661	114238661	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:114238661T>G	uc004epx.2	-	10	1250	c.1125A>C	c.(1123-1125)GAA>GAC	p.E375D		NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	375	Cytoplasmic (Potential).					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity	p.E375K(1)		upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						CACAGAAAAATTCTGGAATCT	0.333												
NKAP	79576	broad.mit.edu	37	X	119068469	119068469	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:119068469T>G	uc004esh.2	-	5	892	c.725A>C	c.(724-726)AAG>ACG	p.K242T	NKAP_uc004esg.2_Missense_Mutation_p.K129T	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	242	Necessary for interaction with CIR1.|Lys-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						TCTGTGTTTCTTCTTCTTTTC	0.194												
THOC2	57187	broad.mit.edu	37	X	122769999	122769999	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:122769999A>T	uc004etu.2	-	19	1981	c.1949T>A	c.(1948-1950)TTT>TAT	p.F650Y	THOC2_uc011muh.1_Missense_Mutation_p.F575Y	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	650					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						ATATTTACGAAAAACTGCACC	0.323												
ODZ1	10178	broad.mit.edu	37	X	123556129	123556129	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:123556129A>C	uc004euj.2	-	23	4507	c.4443T>G	c.(4441-4443)TGT>TGG	p.C1481W	ODZ1_uc011muj.1_Missense_Mutation_p.C1487W|ODZ1_uc010nqy.2_Missense_Mutation_p.C1488W	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1481	Extracellular (Potential).|NHL 5.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TACCTGAAAAACAGTCACAGT	0.433												
GPR112	139378	broad.mit.edu	37	X	135427928	135427928	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:135427928A>G	uc004ezu.1	+	6	2354	c.2063A>G	c.(2062-2064)GAG>GGG	p.E688G	GPR112_uc010nsb.1_Missense_Mutation_p.E483G|GPR112_uc010nsc.1_Missense_Mutation_p.E455G	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	688	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GCATTTCATGAGAATACTACT	0.423												
FGF13	2258	broad.mit.edu	37	X	137717662	137717662	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:137717662T>G	uc004fam.2	-	4	1219	c.557A>C	c.(556-558)AAG>ACG	p.K186T	FGF13_uc004fan.2_Missense_Mutation_p.K133T|FGF13_uc011mwi.1_Missense_Mutation_p.K167T|FGF13_uc004faq.2_Missense_Mutation_p.K196T|FGF13_uc004far.2_Missense_Mutation_p.K167T|FGF13_uc011mwj.1_Missense_Mutation_p.K196T|FGF13_uc011mwk.1_Missense_Mutation_p.K140T	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	186					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CTTGTTCTTCTTCACATGGTT	0.403												
ATP11C	286410	broad.mit.edu	37	X	138828012	138828012	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:138828012T>C	uc004faz.2	-	25	2941	c.2842A>G	c.(2842-2844)ATT>GTT	p.I948V	ATP11C_uc004fax.2_Missense_Mutation_p.I156V|ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.I948V	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	948	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					TTGCCAGAAATTTTCCTATTG	0.398												
SLITRK2	84631	broad.mit.edu	37	X	144906229	144906229	+	Silent	SNP	A	A	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:144906229A>G	uc004fcd.2	+	5	3276	c.2286A>G	c.(2284-2286)CGA>CGG	p.R762R	SLITRK2_uc010nsp.2_Silent_p.R762R|SLITRK2_uc010nso.2_Silent_p.R762R|SLITRK2_uc011mwq.1_Silent_p.R762R|SLITRK2_uc011mwr.1_Silent_p.R762R|SLITRK2_uc011mws.1_Silent_p.R762R|SLITRK2_uc004fcg.2_Silent_p.R762R|SLITRK2_uc011mwt.1_Silent_p.R762R|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	762	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TTGCTGAGCGAGTCAAGGAAC	0.493												
FMR1	2332	broad.mit.edu	37	X	147011719	147011719	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:147011719T>G	uc010nst.2	+	7	775	c.586T>G	c.(586-588)TTG>GTG	p.L196V	FMR1_uc011mwz.1_Missense_Mutation_p.L196V|FMR1_uc004fcj.2_Missense_Mutation_p.L196V|FMR1_uc004fck.3_Missense_Mutation_p.L196V|FMR1_uc004fcl.3_Missense_Mutation_p.L57V|FMR1_uc011mxa.1_5'UTR	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	196					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GCGCACTAAGTTGTCTCTGAT	0.398									Fragile_X_syndrome			
AFF2	2334	broad.mit.edu	37	X	147744022	147744022	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:147744022A>T	uc004fcp.2	+	3	1253	c.774A>T	c.(772-774)TTA>TTT	p.L258F	AFF2_uc004fco.2_Missense_Mutation_p.L254F|AFF2_uc004fcq.2_Missense_Mutation_p.L254F|AFF2_uc004fcr.2_Missense_Mutation_p.L254F|AFF2_uc011mxb.1_Missense_Mutation_p.L258F|AFF2_uc004fcs.2_Missense_Mutation_p.L254F	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	258					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCCTCTTTATTAGCTCCTA	0.488												
PASD1	139135	broad.mit.edu	37	X	150844474	150844474	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:150844474A>C	uc004fev.3	+	16	2513	c.2181A>C	c.(2179-2181)CAA>CAC	p.Q727H		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	727						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GGCAGGTGCAAGTTTCTGAGG	0.502												
FATE1	89885	broad.mit.edu	37	X	150885864	150885864	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:150885864A>T	uc004fex.2	+	2	311	c.227A>T	c.(226-228)AAG>ATG	p.K76M		NM_033085	NP_149076	Q969F0	FATE1_HUMAN	fetal and adult testis expressed transcript	76						endoplasmic reticulum|integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					ACCCGACCCAAGAAAATGGTA	0.567												
MAGEA10	4109	broad.mit.edu	37	X	151304051	151304051	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:151304051T>G	uc004ffk.2	-	5	450	c.42A>C	c.(40-42)GAA>GAC	p.E14D	MAGEA10_uc004ffl.2_Missense_Mutation_p.E14D	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	14											0	Acute lymphoblastic leukemia(192;6.56e-05)					ATTGAAGATCTTCTTCAGGCA	0.567												
GABRA3	2556	broad.mit.edu	37	X	151393246	151393246	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:151393246T>C	uc010ntk.1	-	6	863	c.623A>G	c.(622-624)AAG>AGG	p.K208R		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	208	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCTTCCAAACTTCAGTGGGCA	0.373												
GDI1	2664	broad.mit.edu	37	X	153666940	153666940	+	Silent	SNP	C	C	T			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chrX:153666940C>T	uc004fli.3	+	2	459	c.117C>T	c.(115-117)TAC>TAT	p.Y39Y	GDI1_uc011mzo.1_Silent_p.Y39Y	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	39					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCCCTACTACGGGGGCGAGA	0.617												
COL11A1	1301	broad.mit.edu	37	1	103491428	103491428	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr1:103491427_103491427TG>T	uc001dum.3	-	5	1180	c.862_862CA>A	c.(862-864)aaafs	p.K288fs	COL11A1_uc001duk.3_Intron|COL11A1_uc001dul.3_Intron|COL11A1_uc001dun.3_Intron|COL11A1_uc009weh.3_Intron	NM_080629	NP_542196	P12107	COBA1_HUMAN	Homo sapiens collagen, type XI, alpha 1 (COL11A1), transcript variant B, mRNA.	290	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.P287P(1)		NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTTTCAGATTTGGGGGGTGTA	0.343												
CASP8	841	broad.mit.edu	37	2	202150023	202150024	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr2:202150022_202150023TGA>T	uc002uxr.1	+	8	1495_1496	c.1286_1287TGA>T	c.(1285-1287)ctgfs	p.L429fs	CASP8_uc002uxq.1_Frame_Shift_Del_p.L414fs|CASP8_uc002uxp.1_Frame_Shift_Del_p.L446fs|CASP8_uc002uxu.1_Non-coding_Transcript|CASP8_uc002uxt.1_Frame_Shift_Del_p.L488fs|CASP8_uc002uxw.1_Frame_Shift_Del_p.L414fs|CASP8_uc010ftf.2_Frame_Shift_Del_p.L345fs	NM_033355	NP_203519	Q14790	CASP8_HUMAN	Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant B, mRNA.	429					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						TGCCAGAGCCTGAGAGAGCGAT	0.515										HNSCC(4;0.00038)		
COL1A2	1278	broad.mit.edu	37	7	94057068	94057069	+	Frame_Shift_Ins	INS	-	-	TATGA			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr7:94057067_94057068C>CTATGA	uc003ung.1	+	48	3867_3868	c.3396_3397C>CTATGA	c.(3394-3399)gactatfs	p.D1132fs	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	Homo sapiens collagen, type I, alpha 2 (COL1A2), mRNA.	1132					Rho protein signal transduction|axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GACCCAAGGACTATGAAGTTGA	0.510										HNSCC(75;0.22)		
FAM135B	51059	broad.mit.edu	37	8	139165017	139165017	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr8:139165016_139165016GT>G	uc003yuy.3	-	12	1873	c.1702_1702AC>C	c.(1702-1704)cccfs	p.P568fs	FAM135B_uc003yux.3_Frame_Shift_Del_p.P469fs|FAM135B_uc003yuz.3_Non-coding_Transcript|FAM135B_uc003yva.3_Frame_Shift_Del_p.P130fs|FAM135B_uc003yvb.3_Frame_Shift_Del_p.P130fs	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	Homo sapiens family with sequence similarity 135, member B (FAM135B), mRNA.	568										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCCACCAGGGGTTCAGCTCTG	0.502										HNSCC(54;0.14)		
C11orf48	79081	broad.mit.edu	37	11	62430750	62430752	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr11:62430749_62430751TGGA>T	uc001nuf.3	-	5	934_936	c.718_720TCCA>A	c.(718-720)cca>A	p.P240del	METTL12_uc001nug.1_5'Flank|METTL12_uc001nuh.3_5'Flank|SNORA57_uc009yoa.1_5'Flank|METTL12_uc010rmc.1_5'Flank	NM_024099	NP_077004	Q9BQE6	CK048_HUMAN	Homo sapiens chromosome 11 open reading frame 48 (C11orf48), mRNA.	266										endometrium(1)|lung(5)|urinary_tract(1)	7						CCGGATCTGCTGGAGGAGTTTTC	0.502												
PSG2	5670	broad.mit.edu	37	19	43579745	43579745	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D7-A4Z0-01A-22D-A25D-08	TCGA-D7-A4Z0-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	75d90dfc-06ac-4725-887b-6dcca9eadd6b	ec32faed-705c-4247-9ebb-518ce17cdafb	g.chr19:43579744_43579744GT>G	uc002ovr.3	-	2	643	c.471_471AC>C	c.(469-471)aacfs	p.N157fs	PSG4_uc010xwk.1_Intron	NM_031246	NP_112536	P11465	PSG2_HUMAN	Homo sapiens pregnancy specific beta-1-glycoprotein 2 (PSG2), mRNA.	157	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				CCTCCCTGGGGTTTAAGTTGC	0.522