Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CA6	765	broad.mit.edu	37	1	9030988	9030988	+	Silent	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:9030988C>A	uc001apm.2	+	7	816	c.792C>A	c.(790-792)CGC>CGA	p.R264R	CA6_uc009vmn.2_Silent_p.R204R	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	264					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		ACGATTACCGCAGGACCCAGC	0.522000												
ARID1A	8289	broad.mit.edu	37	1	27100390	27100390	+	Splice_Site	SNP	G	G	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:27100390G>C	uc001bmv.1	+	17	4474	c.4101_splice	c.e17+1	p.Q1367_splice	ARID1A_uc001bmt.1_Splice_Site_p.Q1366_splice|ARID1A_uc001bmu.1_Splice_Site_p.Q1367_splice|ARID1A_uc001bmw.1_Splice_Site_p.Q984_splice|ARID1A_uc001bmx.1_Splice_Site_p.Q213_splice|ARID1A_uc009vsm.1_Splice_Site|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCAACAGCAGGTGAGGAGGGT	0.483000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
WASF2	10163	broad.mit.edu	37	1	27742538	27742538	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:27742538A>G	uc001bof.1	-	5	694	c.478T>C	c.(478-480)TGG>CGG	p.W160R	WASF2_uc010ofl.1_Missense_Mutation_p.W160R	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	160				WK->ED: Constitutive induction of the formation of actin filaments. Strongly enhances formation of lamellipodia.	actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TTCTCCTTCCAAAGATCAAAG	0.463000												
ODF2L	57489	broad.mit.edu	37	1	86826191	86826191	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:86826191A>T	uc001dll.1	-	12	1512	c.1172T>A	c.(1171-1173)GTT>GAT	p.V391D	ODF2L_uc001dlm.1_Missense_Mutation_p.V362D|ODF2L_uc001dln.2_Missense_Mutation_p.V362D|ODF2L_uc001dlo.2_Missense_Mutation_p.V231D|ODF2L_uc001dlp.2_Missense_Mutation_p.V391D|ODF2L_uc010osg.1_Missense_Mutation_p.V362D|ODF2L_uc001dlq.1_Missense_Mutation_p.V192D|ODF2L_uc009wcr.1_Missense_Mutation_p.V231D	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	391	Potential.					centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		AACAGATACAACTTCATCCTT	0.294000												
OLFM3	118427	broad.mit.edu	37	1	102302454	102302454	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:102302454A>C	uc001duf.2	-	2	328	c.257T>G	c.(256-258)CTT>CGT	p.L86R	OLFM3_uc001dug.2_Missense_Mutation_p.L66R|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_5'UTR|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	86	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TAGTTGGCGAAGTTGCCTGCT	0.463000												
KCNA10	3744	broad.mit.edu	37	1	111060346	111060346	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:111060346G>A	uc001dzt.1	-	1	1452	c.1064C>T	c.(1063-1065)TCG>TTG	p.S355L		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	355	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GGAGTGGCGCGAGAGCTTGAA	0.577000												
DCLRE1B	64858	broad.mit.edu	37	1	114454003	114454003	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:114454003C>A	uc001eeg.2	+	4	960	c.789C>A	c.(787-789)AGC>AGA	p.S263R	DCLRE1B_uc001eeh.2_Missense_Mutation_p.S137R|DCLRE1B_uc001eei.2_Missense_Mutation_p.S137R	NM_022836	NP_073747	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B (PSO2 homolog, S.	263					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding				0	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATCCACAGCTCCCACCCTG	0.532000								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function				
CD5L	922	broad.mit.edu	37	1	157803243	157803243	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:157803243G>T	uc001frk.3	-	5	921	c.778C>A	c.(778-780)CTG>ATG	p.L260M		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	260	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCCTTGTGCAGCACCTCCAGT	0.572000												
CD1C	911	broad.mit.edu	37	1	158259792	158259792	+	Translation_Start_Site	SNP	A	A	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:158259792A>T	uc001fru.2	+	1	230	c.-62A>T	c.(-64--60)TAAGT>TATGT		CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor						antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					CAGAGGGATAAGTTTGCTAAG	0.438000												
SPTA1	6708	broad.mit.edu	37	1	158606546	158606546	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:158606546T>G	uc001fst.1	-	37	5394	c.5195A>C	c.(5194-5196)AAG>ACG	p.K1732T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1732	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCGTATCAACTTCTCCCTAAA	0.473000												
SPTA1	6708	broad.mit.edu	37	1	158607915	158607915	+	Silent	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:158607915T>C	uc001fst.1	-	36	5296	c.5097A>G	c.(5095-5097)CAA>CAG	p.Q1699Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1699	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTGCCAATTCTTGGACATTCA	0.428000												
CENPF	1063	broad.mit.edu	37	1	214816265	214816265	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:214816265C>A	uc001hkm.2	+	12	4758	c.4584C>A	c.(4582-4584)TGC>TGA	p.C1528*		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1624	1-2.|2 X 96 AA approximate tandem repeats.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAGTATTTTGCAGCAGTCTGC	0.478000												
CHML	1122	broad.mit.edu	37	1	241798734	241798734	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:241798734T>C	uc001hzd.2	-	1	499	c.335A>G	c.(334-336)AAC>AGC	p.N112S	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	112					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CTCTTCAACGTTGTCCTCCAT	0.433000												
OR2M5	127059	broad.mit.edu	37	1	248308749	248308749	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:248308749A>C	uc010pze.1	+	1	300	c.300A>C	c.(298-300)CAA>CAC	p.Q100H		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	100	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GTGCCACACAAATTTTCTTCT	0.463000												
OR14I1	401994	broad.mit.edu	37	1	248845550	248845550	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:248845550C>A	uc001ieu.1	-	1	56	c.56G>T	c.(55-57)TGG>TTG	p.W19L		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGCAGCTCCCAGATACCAGA	0.468000												
SFMBT2	57713	broad.mit.edu	37	10	7409728	7409728	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:7409728G>A	uc009xio.1	-	4	410	c.319C>T	c.(319-321)CGC>TGC	p.R107C	SFMBT2_uc001ijn.1_Missense_Mutation_p.R107C|SFMBT2_uc010qay.1_Missense_Mutation_p.R107C|SFMBT2_uc001ijo.1_Missense_Mutation_p.R107C	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	107	MBT 1.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CCGCAGTAGCGCAGAAGCAGC	0.577000												
CUBN	8029	broad.mit.edu	37	10	17061928	17061928	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:17061928G>T	uc001ioo.2	-	28	4124	c.4072C>A	c.(4072-4074)CCA>ACA	p.P1358T		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1358	CUB 8.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTACTCCCTGGAGGGGGCAGG	0.488000												
NEBL	10529	broad.mit.edu	37	10	21112165	21112165	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:21112165A>C	uc001iqi.2	-	19	2331	c.1934T>G	c.(1933-1935)GTT>GGT	p.V645G	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	645	Nebulin 18.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						GTTTTCTTTAACTCTCTTTAG	0.284000												
FAM13C	220965	broad.mit.edu	37	10	61012739	61012739	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:61012739T>G	uc001jkn.2	-	13	1486	c.1352A>C	c.(1351-1353)GAT>GCT	p.D451A	FAM13C_uc001jko.2_Missense_Mutation_p.D353A|FAM13C_uc010qid.1_Missense_Mutation_p.D367A|FAM13C_uc010qie.1_Missense_Mutation_p.D368A|FAM13C_uc010qif.1_Missense_Mutation_p.D473A	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	451										ovary(2)	2						ACGGTCTTCATCAGAGTCCTC	0.478000												
ZNF365	22891	broad.mit.edu	37	10	64425905	64425905	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:64425905A>C	uc001jmd.1	+	6	833	c.499A>C	c.(499-501)AGT>CGT	p.S167R	ZNF365_uc001jmc.2_Missense_Mutation_p.S413R|ZNF365_uc001jme.1_RNA|ZNF365_uc001jmf.1_RNA|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	167										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					TGTCTCTACAAGTCAAAGCAG	0.373000												
KCNMA1	3778	broad.mit.edu	37	10	78709036	78709036	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:78709036C>T	uc001jxn.2	-	22	2750	c.2573G>A	c.(2572-2574)CGG>CAG	p.R858Q	KCNMA1_uc001jxj.2_Missense_Mutation_p.R804Q|KCNMA1_uc001jxk.1_Missense_Mutation_p.R476Q|KCNMA1_uc009xrt.1_Missense_Mutation_p.R649Q|KCNMA1_uc001jxl.1_Missense_Mutation_p.R483Q|KCNMA1_uc001jxo.2_Missense_Mutation_p.R841Q|KCNMA1_uc001jxm.2_Missense_Mutation_p.R800Q|KCNMA1_uc001jxq.2_Missense_Mutation_p.R803Q	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	858	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CACCAGGTTCCGGAGGCCGAT	0.557000												
KIF20B	9585	broad.mit.edu	37	10	91484893	91484893	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:91484893G>T	uc001kgs.1	+	15	2051	c.1979G>T	c.(1978-1980)TGT>TTT	p.C660F	KIF20B_uc001kgr.1_Missense_Mutation_p.C660F|KIF20B_uc001kgt.1_5'UTR	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	660					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						AAAGACATTTGTGCCACAAAA	0.373000												
C10orf95	79946	broad.mit.edu	37	10	104210877	104210877	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:104210877C>G	uc001kvo.1	-	2	186	c.111G>C	c.(109-111)AAG>AAC	p.K37N	uc001kvp.1_Intron|uc001kvq.1_Intron|uc001kvr.1_5'Flank	NM_024886	NP_079162	Q9H7T3	CJ095_HUMAN	hypothetical protein LOC79946	37										liver(1)	1		Colorectal(252;0.207)		Epithelial(162;8.34e-09)|all cancers(201;1.95e-07)|BRCA - Breast invasive adenocarcinoma(275;0.213)		GGCTGCTGTTCTTACTGGGGG	0.657000												
PNLIPRP3	119548	broad.mit.edu	37	10	118228808	118228808	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:118228808G>T	uc001lcl.3	+	9	1140	c.1039G>T	c.(1039-1041)GGG>TGG	p.G347W		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	347					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		TTTAAACACAGGGTCCCTTTC	0.294000												
PTPRE	5791	broad.mit.edu	37	10	129869126	129869126	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:129869126G>A	uc001lkb.2	+	15	1627	c.1348G>A	c.(1348-1350)GCA>ACA	p.A450T	PTPRE_uc009yat.2_Missense_Mutation_p.A461T|PTPRE_uc009yau.2_Missense_Mutation_p.A450T|PTPRE_uc001lkd.2_Missense_Mutation_p.A392T|PTPRE_uc010quq.1_Missense_Mutation_p.A351T	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	450	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				CAACTTGCCGGCAAACATGAA	0.552000												
OR52E6	390078	broad.mit.edu	37	11	5862280	5862280	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:5862280A>T	uc010qzq.1	-	1	848	c.848T>A	c.(847-849)GTT>GAT	p.V283D	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGAGGAACAACCACATATAG	0.403000												
OR10A4	283297	broad.mit.edu	37	11	6898077	6898077	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:6898077T>G	uc010rat.1	+	1	199	c.199T>G	c.(199-201)TTG>GTG	p.L67V		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCTCAGAAACTTGTCCTTCCT	0.458000												
OR4X2	119764	broad.mit.edu	37	11	48267435	48267435	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:48267435C>A	uc001ngs.1	+	1	780	c.780C>A	c.(778-780)GAC>GAA	p.D260E		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGCCCATAGACAAGATGGTGG	0.512000												
DAGLA	747	broad.mit.edu	37	11	61511242	61511242	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:61511242C>T	uc001nsa.2	+	20	2521	c.2410C>T	c.(2410-2412)CGG>TGG	p.R804W		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	804	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		CCGCAGCATCCGGGGCTCCCC	0.662000												
AHNAK	79026	broad.mit.edu	37	11	62299852	62299852	+	Silent	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:62299852T>C	uc001ntl.2	-	5	2337	c.2037A>G	c.(2035-2037)AAA>AAG	p.K679K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	679					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GGCCTTTAAGTTTTCCCCCCA	0.473000												
NUDT22	84304	broad.mit.edu	37	11	63994300	63994300	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:63994300C>G	uc001nyp.3	+	2	356	c.176C>G	c.(175-177)CCC>CGC	p.P59R	TRPT1_uc010rnc.1_5'Flank|TRPT1_uc010rnd.1_5'Flank|TRPT1_uc001nyn.2_5'Flank|TRPT1_uc001nyo.2_5'Flank|TRPT1_uc010rne.1_5'Flank|TRPT1_uc010rnf.1_5'Flank|NUDT22_uc009ypd.2_Missense_Mutation_p.P59R|NUDT22_uc009ype.2_Missense_Mutation_p.P59R|NUDT22_uc001nyq.3_Missense_Mutation_p.P59R|NUDT22_uc010rng.1_5'Flank	NM_032344	NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety	59							hydrolase activity				0						TTCGACGCCCCCAAGTTCCGC	0.677000												
NADSYN1	55191	broad.mit.edu	37	11	71209472	71209472	+	Silent	SNP	G	G	A	rs147528912	byFrequency	TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:71209472G>A	uc001oqn.2	+	20	2094	c.1968G>A	c.(1966-1968)GCG>GCA	p.A656A	NADSYN1_uc001oqo.2_Silent_p.A396A|NADSYN1_uc001oqp.2_Silent_p.A285A	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	656	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCACACCCGCGTACCACGCCG	0.522000												
FCHSD2	9873	broad.mit.edu	37	11	72553748	72553748	+	Missense_Mutation	SNP	C	C	T	rs147782509		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:72553748C>T	uc009ytl.2	-	17	2065	c.1844G>A	c.(1843-1845)CGT>CAT	p.R615H	FCHSD2_uc010rrg.1_Missense_Mutation_p.R479H|FCHSD2_uc001oth.3_Missense_Mutation_p.R559H|ATG16L2_uc009ytj.1_3'UTR	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	615	SH3 2.						protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			AACTCCAATACGCCCATTGAA	0.453000												
KLHL35	283212	broad.mit.edu	37	11	75134734	75134734	+	Splice_Site	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:75134734A>G	uc001owm.1	-	5	1122	c.903_splice	c.e5+1	p.V301_splice		NM_001039548	NP_001034637	Q6PF15	KLH35_HUMAN	kelch-like 35												0						GCCTCCACTTACCACAGGGCT	0.473000												
FAT3	120114	broad.mit.edu	37	11	92534886	92534886	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:92534886T>G	uc001pdj.3	+	9	8724	c.8707T>G	c.(8707-8709)TCT>GCT	p.S2903A		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2903	Cadherin 26.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGAGGCATTCTCTCTTTCCTC	0.527000										TCGA Ovarian(4;0.039)		
FAM55D	54827	broad.mit.edu	37	11	114453577	114453577	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:114453577A>G	uc001ppc.2	-	3	444	c.263T>C	c.(262-264)TTC>TCC	p.F88S	FAM55D_uc001ppd.2_5'UTR	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	88						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		CACGTGGGTGAAAGGTCTGGG	0.498000												
OR10G4	390264	broad.mit.edu	37	11	123886648	123886648	+	Silent	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:123886648T>C	uc010sac.1	+	1	367	c.367T>C	c.(367-369)TTG>CTG	p.L123L		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	123	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TGATCGCTACTTGGCCATCAG	0.567000												
OR8D2	283160	broad.mit.edu	37	11	124189952	124189952	+	Silent	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:124189952A>G	uc010sah.1	-	1	142	c.142T>C	c.(142-144)TTA>CTA	p.L48L		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		AGAGCAATTAAGAAGATCATG	0.453000												
NTM	50863	broad.mit.edu	37	11	132177683	132177683	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr11:132177683G>A	uc001qgp.2	+	4	1291	c.627G>A	c.(625-627)GCG>GCA	p.A209A	NTM_uc001qgm.2_Silent_p.A209A|NTM_uc010sch.1_Silent_p.A200A|NTM_uc010sci.1_Silent_p.A209A|NTM_uc010scj.1_Silent_p.A168A|NTM_uc001qgo.2_Silent_p.A209A|NTM_uc001qgq.2_Silent_p.A209A|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	209	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						ACGTGGCCGCGCCCGTGGTAC	0.582000												
PDE3A	5139	broad.mit.edu	37	12	20523121	20523121	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:20523121C>T	uc001reh.1	+	1	925	c.903C>T	c.(901-903)TCC>TCT	p.S301S		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	301					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCGAGATGTCCGGCTGCAGCA	0.587000												
LRRK2	120892	broad.mit.edu	37	12	40692165	40692165	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:40692165T>C	uc001rmg.3	+	24	3338	c.3217T>C	c.(3217-3219)TCA>CCA	p.S1073P	LRRK2_uc001rmh.1_Missense_Mutation_p.S695P|LRRK2_uc009zjw.2_5'UTR	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1073	LRR 4.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CATTGGACCCTCAGTGGTTTT	0.368000												
DDX23	9416	broad.mit.edu	37	12	49224310	49224310	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:49224310T>C	uc001rsm.2	-	17	2496	c.2405A>G	c.(2404-2406)CAG>CGG	p.Q802R		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	802						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						TGGCTTATGCTGGGCATCTGG	0.562000												
KRT73	319101	broad.mit.edu	37	12	53009982	53009982	+	Silent	SNP	G	G	A	rs116369374	by1000genomes	TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:53009982G>A	uc001sas.2	-	2	665	c.630C>T	c.(628-630)AGC>AGT	p.S210S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	210	Coil 1B.|Rod.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTTCGCGCACGCTCCTCAGCT	0.622000												
ERBB3	2065	broad.mit.edu	37	12	56478854	56478854	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:56478854G>A	uc001sjh.2	+	3	503	c.310G>A	c.(310-312)GTG>ATG	p.V104M	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V45M|ERBB3_uc001sjg.2_Missense_Mutation_p.V104M	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	104	Extracellular (Potential).		V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(1)		lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAACCTCCGCGTGGTGCGAGG	0.517000												
PTPRB	5787	broad.mit.edu	37	12	71016170	71016170	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:71016170C>G	uc001swc.3	-	3	752	c.708G>C	c.(706-708)GAG>GAC	p.E236D	PTPRB_uc001swa.3_Missense_Mutation_p.E236D|PTPRB_uc001swd.3_Missense_Mutation_p.E235D|PTPRB_uc009zrr.1_Missense_Mutation_p.E115D|PTPRB_uc001swe.2_Missense_Mutation_p.E236D	NM_001109754	NP_001103224	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCCTTTTACCTCTTCAGTGG	0.512000												
E2F7	144455	broad.mit.edu	37	12	77436957	77436957	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:77436957G>C	uc001sym.3	-	7	1247	c.1011C>G	c.(1009-1011)GAC>GAG	p.D337E		NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	337	Potential.				cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						CATTGGCTATGTCATAGAGGC	0.453000												
TMCC3	57458	broad.mit.edu	37	12	94976035	94976035	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:94976035G>C	uc001tdj.2	-	2	476	c.358C>G	c.(358-360)CAG>GAG	p.Q120E	TMCC3_uc001tdi.2_Missense_Mutation_p.Q89E	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	120	Potential.					integral to membrane				ovary(1)|skin(1)	2						GCTGATTTCTGATTCTTCTTC	0.488000												
NUAK1	9891	broad.mit.edu	37	12	106461395	106461395	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:106461395T>G	uc001tlj.1	-	7	2551	c.1171A>C	c.(1171-1173)AAG>CAG	p.K391Q		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	391							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						GAACTCAACTTGGATGGGCTT	0.527000												
POLR3B	55703	broad.mit.edu	37	12	106897865	106897865	+	Silent	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:106897865C>A	uc001tlp.2	+	27	3327	c.3105C>A	c.(3103-3105)CCC>CCA	p.P1035P	POLR3B_uc001tlq.2_Silent_p.P977P	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	1035					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						AAAGGCAACCCACTGAAGGAC	0.323000												
NAA25	80018	broad.mit.edu	37	12	112480946	112480946	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:112480946T>C	uc001ttm.2	-	19	2340	c.2320A>G	c.(2320-2322)ATA>GTA	p.I774V	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.I746V|NAA25_uc009zwa.1_Missense_Mutation_p.I774V	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	774						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						AAAGAGCTTATCTGGCACTGA	0.378000												
FZD10	11211	broad.mit.edu	37	12	130648665	130648665	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:130648665C>T	uc001uii.2	+	1	1634	c.1178C>T	c.(1177-1179)GCG>GTG	p.A393V	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	393	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GACGTCAACGCGCTCACCGGC	0.657000												
DDX51	317781	broad.mit.edu	37	12	132624651	132624651	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr12:132624651G>A	uc001ujy.3	-	12	1806	c.1767C>T	c.(1765-1767)TAC>TAT	p.Y589Y		NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	589	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		ACCGGTGCACGTAGGTTCTCA	0.682000												
MPHOSPH8	54737	broad.mit.edu	37	13	20235930	20235930	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr13:20235930C>T	uc001umh.2	+	8	1893	c.1884C>T	c.(1882-1884)AAC>AAT	p.N628N	MPHOSPH8_uc001umg.2_Silent_p.N628N	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	628	ANK 1.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		CGAAAGTGAACGGTCGGCAGA	0.552000												
CCNA1	8900	broad.mit.edu	37	13	37014301	37014301	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr13:37014301G>A	uc001uvr.3	+	6	1429	c.1079G>A	c.(1078-1080)AGG>AAG	p.R360K	CCNA1_uc010teo.1_Missense_Mutation_p.R316K|CCNA1_uc010abq.2_Missense_Mutation_p.R316K|CCNA1_uc010abp.2_Missense_Mutation_p.R316K|CCNA1_uc001uvs.3_Missense_Mutation_p.R359K|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	360					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		GTGTGCGTCAGGACTGAGAAC	0.468000												
POSTN	10631	broad.mit.edu	37	13	38172767	38172767	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr13:38172767G>A	uc001uwo.3	-	1	215	c.97C>T	c.(97-99)CGT>TGT	p.R33C	POSTN_uc001uwp.3_Missense_Mutation_p.R33C|POSTN_uc001uwr.2_Missense_Mutation_p.R33C|POSTN_uc001uwq.2_Missense_Mutation_p.R33C|POSTN_uc010teu.1_Missense_Mutation_p.R33C|POSTN_uc010tev.1_Missense_Mutation_p.R33C|POSTN_uc010tew.1_Missense_Mutation_p.R33C|POSTN_uc010tex.1_Intron	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	33					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CCCCTGATACGACTATGAGCC	0.378000												
C13orf18	80183	broad.mit.edu	37	13	46946558	46946558	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr13:46946558C>T	uc010acl.2	-	3	658	c.53G>A	c.(52-54)GGG>GAG	p.G18E	C13orf18_uc001vbf.3_Intron|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Intron|C13orf18_uc010acm.2_Intron|C13orf18_uc010acn.2_Intron|C13orf18_uc001vbe.3_Missense_Mutation_p.G18E|C13orf18_uc001vbh.3_Missense_Mutation_p.G18E|C13orf18_uc001vbi.3_Intron|C13orf18_uc010aco.1_Missense_Mutation_p.G18E|C13orf18_uc010tga.1_Intron	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	18											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		ATCGCTGATCCCTTCCCAGGG	0.502000												
MYCBP2	23077	broad.mit.edu	37	13	77635848	77635848	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr13:77635848G>A	uc001vkf.2	-	76	12829	c.12738C>T	c.(12736-12738)GAC>GAT	p.D4246D	MYCBP2_uc010aev.2_Silent_p.D3650D|MYCBP2_uc001vke.2_Silent_p.D863D	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ATCTGTCACAGTCTGTACATA	0.358000												
STK24	8428	broad.mit.edu	37	13	99109504	99109504	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr13:99109504G>A	uc001vnm.1	-	10	1448	c.1213C>T	c.(1213-1215)CGA>TGA	p.R405*	STK24_uc001vnn.1_Nonsense_Mutation_p.R393*|STK24_uc010tim.1_Nonsense_Mutation_p.R374*	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	405					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			ATGGCCCCTCGCAGCTCTTCA	0.612000												
RIPK3	11035	broad.mit.edu	37	14	24805445	24805445	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr14:24805445T>C	uc001wpb.2	-	10	1703	c.1493A>G	c.(1492-1494)GAA>GGA	p.E498G	ADCY4_uc001wov.2_5'Flank|ADCY4_uc001wow.2_5'Flank|ADCY4_uc010toh.1_5'Flank|ADCY4_uc001wox.2_5'Flank|ADCY4_uc001woy.2_5'Flank|ADCY4_uc001woz.3_5'Flank|RIPK3_uc001wpa.2_Missense_Mutation_p.E298G|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_Missense_Mutation_p.E277G	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	498					apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		TTTAGGGCCTTCTTGCGAACC	0.547000												
NPAS3	64067	broad.mit.edu	37	14	34270197	34270197	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr14:34270197C>T	uc001wru.2	+	12	2748	c.2684C>T	c.(2683-2685)ACG>ATG	p.T895M	NPAS3_uc001wrs.2_Missense_Mutation_p.T882M|NPAS3_uc001wrt.2_Missense_Mutation_p.T863M|NPAS3_uc001wrv.2_Missense_Mutation_p.T865M	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	895					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GCTAGCCTGACGCAGATGCCC	0.657000												
HSP90AA1	3320	broad.mit.edu	37	14	102552358	102552358	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr14:102552358A>G	uc001yku.3	-	3	456	c.266T>C	c.(265-267)CTC>CCC	p.L89P	HSP90AA1_uc001ykv.3_Missense_Mutation_p.L211P|HSP90AA1_uc001ykw.1_Intron|HSP90AA1_uc001ykx.1_Missense_Mutation_p.L78P	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	89					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CACAATAGTGAGAGTTCGATC	0.423000												
PAK6	56924	broad.mit.edu	37	15	40564645	40564645	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:40564645G>A	uc010bbl.2	+	6	1519	c.1079G>A	c.(1078-1080)AGC>AAC	p.S360N	PAK6_uc010bbm.2_Missense_Mutation_p.S360N|PAK6_uc001zky.3_Missense_Mutation_p.S360N|PAK6_uc010bbn.2_Missense_Mutation_p.S360N|PAK6_uc001zlb.2_Missense_Mutation_p.S360N	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	360	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		GCCCAGATCAGCACCAGCAAC	0.672000												
FBN1	2200	broad.mit.edu	37	15	48807654	48807655	+	Missense_Mutation	DNP	AA	AA	CT			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:48807654_48807655AA>CT	uc001zwx.1	-	12	1725_1726	c.1397_1398TT>AG	c.(1396-1398)ATT>AAG	p.I466K		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	466	EGF-like 6.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CAGGAGTTGGAATGCAGCGTCC	0.500000												
FBN1	2200	broad.mit.edu	37	15	48818420	48818420	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:48818420A>G	uc001zwx.1	-	9	1223	c.895T>C	c.(895-897)TGT>CGT	p.C299R		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	299	EGF-like 5; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCCCCTTCACAGATTCCAGGA	0.398000												
RNF111	54778	broad.mit.edu	37	15	59381897	59381897	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:59381897G>A	uc002afv.2	+	11	2861	c.2582G>A	c.(2581-2583)CGT>CAT	p.R861H	RNF111_uc002afs.2_Missense_Mutation_p.R861H|RNF111_uc002aft.2_Missense_Mutation_p.R870H|RNF111_uc002afu.2_Missense_Mutation_p.R860H|RNF111_uc002afw.2_Missense_Mutation_p.R870H|RNF111_uc002afx.2_Missense_Mutation_p.R387H|RNF111_uc002afy.2_Missense_Mutation_p.R12H	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	861					multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		CCTCACATCCGTTACATTTCA	0.348000												
NARG2	79664	broad.mit.edu	37	15	60741737	60741737	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:60741737C>A	uc002agp.2	-	10	1664	c.1429G>T	c.(1429-1431)GGC>TGC	p.G477C	NARG2_uc002ago.2_Missense_Mutation_p.G340C|NARG2_uc002agq.3_Missense_Mutation_p.G145C	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	477						nucleus				ovary(1)|lung(1)	2						TCCTCAGGGCCACCATCCATA	0.388000												
PTPLAD1	51495	broad.mit.edu	37	15	65862541	65862541	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:65862541G>A	uc002apc.2	+	8	921	c.773G>A	c.(772-774)AGG>AAG	p.R258K	PTPLAD1_uc002apb.1_RNA|PTPLAD1_uc010uiw.1_Missense_Mutation_p.R203K	NM_016395	NP_057479	Q9P035	HACD3_HUMAN	protein tyrosine phosphatase-like A domain	258	Cytoplasmic (Potential).				activation of JUN kinase activity|fatty acid biosynthetic process|I-kappaB kinase/NF-kappaB cascade|Rac protein signal transduction	endoplasmic reticulum membrane|integral to membrane	GTPase activator activity|lyase activity|protein binding				0						GAAATTTTCAGGTGGGTAGAA	0.393000												
CPEB1	64506	broad.mit.edu	37	15	83296110	83296110	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:83296110T>G	uc002bit.2	-	2	341	c.204A>C	c.(202-204)GAA>GAC	p.E68D	CPEB1_uc002biu.2_Missense_Mutation_p.E35D|CPEB1_uc010uof.1_5'UTR|CPEB1_uc002biv.2_Missense_Mutation_p.E8D	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	8					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			TCCTTCCTGCTTCTTCTTCCT	0.393000												
RGMA	56963	broad.mit.edu	37	15	93595502	93595502	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:93595502C>T	uc002bss.1	-	3	638	c.366G>A	c.(364-366)TCG>TCA	p.S122S	RGMA_uc002bsq.1_Silent_p.S106S|RGMA_uc010boi.1_Silent_p.S13S|RGMA_uc002bsr.1_Silent_p.S13S|RGMA_uc010urc.1_Silent_p.S130S	NM_020211	NP_064596	Q96B86	RGMA_HUMAN	RGM domain family, member A precursor	122					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane					0	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GGCGTGGCTGCGAGGTGGGGC	0.667000												
NPW	283869	broad.mit.edu	37	16	2070128	2070128	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr16:2070128G>A	uc002coh.3	+	1	608	c.226G>A	c.(226-228)GAC>AAC	p.D76N		NM_001099456	NP_001092926	Q8N729	NPW_HUMAN	neuropeptide W preproprotein	76					feeding behavior|neuropeptide signaling pathway	extracellular region					0						ccTGGCCAGGGACACCCTCTC	0.597000												
IRX5	10265	broad.mit.edu	37	16	54967412	54967412	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr16:54967412C>T	uc002ehv.2	+	3	1079	c.1079C>T	c.(1078-1080)CCA>CTA	p.P360L	IRX5_uc002ehw.2_Missense_Mutation_p.P294L	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	360					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						TCTCCATGCCCACCGTGTCCC	0.701000												
DPEP3	64180	broad.mit.edu	37	16	68011675	68011675	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr16:68011675C>T	uc002evc.3	-	6	983	c.889G>A	c.(889-891)GAC>AAC	p.D297N	DPEP3_uc010cex.2_Missense_Mutation_p.D297N	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	272					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		ATCAAGGTGTCCGATGCATAG	0.488000												
CDH1	999	broad.mit.edu	37	16	68842415	68842415	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr16:68842415C>T	uc002ewg.1	+	4	600	c.476C>T	c.(475-477)CCT>CTT	p.P159L	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.P159L	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	159	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.V157_Q177del(1)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TGGGTTATTCCTCCCATCAGC	0.473000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
YWHAE	7531	broad.mit.edu	37	17	1264561	1264561	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:1264561A>T	uc002fsj.2	-	4	555	c.403T>A	c.(403-405)TTT>ATT	p.F135I	YWHAE_uc002fsk.2_Missense_Mutation_p.F113I|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_Intron	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	135					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		CCTGTGGCAAATTCTGCCAGA	0.388000												
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:7578275G>A	uc002gim.2	-	6	768	c.574C>T	c.(574-576)CAG>TAG	p.Q192*	TP53_uc002gig.1_Nonsense_Mutation_p.Q192*|TP53_uc002gih.2_Nonsense_Mutation_p.Q192*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.Q60*|TP53_uc010cng.1_Nonsense_Mutation_p.Q60*|TP53_uc002gii.1_Nonsense_Mutation_p.Q60*|TP53_uc010cnh.1_Nonsense_Mutation_p.Q192*|TP53_uc010cni.1_Nonsense_Mutation_p.Q192*|TP53_uc002gij.2_Nonsense_Mutation_p.Q192*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.Q99*|TP53_uc002gio.2_Nonsense_Mutation_p.Q60*|TP53_uc010vug.1_Nonsense_Mutation_p.Q153*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	192	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Q -> P (in sporadic cancers; somatic mutation).|Q -> H (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(64)|p.0?(7)|p.Q192R(5)|p.A189_V197delAPPQHLIRV(4)|p.Q192H(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.Q192Q(2)|p.P191del(2)|p.K164_P219del(1)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.A189fs*53(1)|p.Q192fs*56(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
SEZ6	124925	broad.mit.edu	37	17	27284988	27284988	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:27284988T>C	uc002hdp.2	-	11	2473	c.2279A>G	c.(2278-2280)GAG>GGG	p.E760G	SEZ6_uc010crx.1_5'Flank|SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.E760G|SEZ6_uc002hdq.1_Missense_Mutation_p.E635G	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	760	Extracellular (Potential).|Sushi 3.					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GGGCAGGTCCTCACTCCAAGT	0.468000												
ANKRD13B	124930	broad.mit.edu	37	17	27939281	27939281	+	Silent	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:27939281A>G	uc002hei.2	+	11	1361	c.1248A>G	c.(1246-1248)CCA>CCG	p.P416P	ANKRD13B_uc002heh.2_Silent_p.P284P|ANKRD13B_uc002hej.2_RNA|ANKRD13B_uc002hek.2_5'Flank	NM_152345	NP_689558	Q86YJ7	AN13B_HUMAN	ankyrin repeat domain 13B	416											0						CTGGCTTCCCAGTTAAGATTG	0.622000												
NEUROD2	4761	broad.mit.edu	37	17	37762570	37762570	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:37762570C>T	uc002hry.2	-	2	483	c.283G>A	c.(283-285)GAG>AAG	p.E95K		NM_006160	NP_006151	Q15784	NDF2_HUMAN	neurogenic differentiation 2	95					cellular response to calcium ion|cellular response to electrical stimulus|cerebellar cortex development|negative regulation of synapse maturation|positive regulation of calcium-mediated signaling|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of synapse maturation|positive regulation of synaptic plasticity|protein ubiquitination|regulation of transcription from RNA polymerase II promoter	nucleus	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Lung(15;0.00549)|LUAD - Lung adenocarcinoma(14;0.0664)			CCCTCCGCCTCGTCCAGTCCT	0.502000												
KRT10	3858	broad.mit.edu	37	17	38978350	38978350	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:38978350T>C	uc002hvi.2	-	1	514	c.488A>G	c.(487-489)AAA>AGA	p.K163R	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	163	Coil 1A.|Rod.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				AGCCCGAACTTTGTCCAAGTA	0.418000												
KRT20	54474	broad.mit.edu	37	17	39041346	39041346	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:39041346G>A	uc002hvl.2	-	1	134	c.92C>T	c.(91-93)ACG>ATG	p.T31M		NM_019010	NP_061883	P35900	K1C20_HUMAN	keratin 20	31	Head.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			large_intestine(1)|kidney(1)|skin(1)	3		Breast(137;0.000301)|Ovarian(249;0.15)				GCTGGGTGTCGTCCCGAGGCG	0.607000												
CNTNAP1	8506	broad.mit.edu	37	17	40839908	40839908	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:40839908C>T	uc002iay.2	+	8	1431	c.1215C>T	c.(1213-1215)GAC>GAT	p.D405D	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	405	Laminin G-like 2.|Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GTCTGGGGGACGGGCTGGGCC	0.652000												
SOST	50964	broad.mit.edu	37	17	41833119	41833119	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:41833119T>G	uc002iec.1	-	2	280	c.233A>C	c.(232-234)TAC>TCC	p.Y78S		NM_025237	NP_079513	Q9BQB4	SOST_HUMAN	sclerostin precursor	78					negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of ossification|negative regulation of protein complex assembly|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway		heparin binding|protein binding				0		Breast(137;0.00725)		UCEC - Uterine corpus endometrioid carcinoma (308;0.177)|BRCA - Breast invasive adenocarcinoma(366;0.0741)		GCGGCAGCTGTACTCGGACAC	0.726000												
MPP3	4356	broad.mit.edu	37	17	41907136	41907136	+	Silent	SNP	C	C	T	rs34890360		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:41907136C>T	uc002iei.3	-	7	493	c.327G>A	c.(325-327)ACG>ACA	p.T109T	MPP3_uc002ieh.2_Silent_p.T134T|MPP3_uc002iej.2_RNA|MPP3_uc010czi.1_Silent_p.T109T|MPP3_uc010wik.1_Silent_p.T134T|MPP3_uc010czj.1_3'UTR	NM_001932	NP_001923	Q13368	MPP3_HUMAN	palmitoylated membrane protein 3	109	L27 2.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity	p.T109T(1)		large_intestine(1)|skin(1)	2		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		TCTGGGCAACCGTGTCATGTA	0.572000												
BTBD17	388419	broad.mit.edu	37	17	72353345	72353345	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:72353345C>T	uc002jkn.2	-	3	888	c.888G>A	c.(886-888)TCG>TCA	p.S296S		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	296						extracellular region					0						AGTGCAGCGGCGACGCGGCGT	0.716000												
TMEM104	54868	broad.mit.edu	37	17	72832361	72832361	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr17:72832361C>T	uc002jls.3	+	10	1188	c.1026C>T	c.(1024-1026)TTC>TTT	p.F342F	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Silent_p.F342F	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	342	Extracellular (Potential).					integral to membrane					0	all_lung(278;0.23)					CCCTCAACTTCGCGCGCTGTG	0.612000												
PTPRM	5797	broad.mit.edu	37	18	8343485	8343485	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:8343485C>G	uc002knn.3	+	21	3485	c.2982C>G	c.(2980-2982)ATC>ATG	p.I994M	PTPRM_uc010dkv.2_Missense_Mutation_p.I1007M|PTPRM_uc010wzl.1_Missense_Mutation_p.I781M	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	994	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CTGCAAGTATCATCATGGTGA	0.453000												
CEP192	55125	broad.mit.edu	37	18	13049226	13049226	+	Silent	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:13049226T>G	uc010xac.1	+	16	2516	c.2436T>G	c.(2434-2436)TCT>TCG	p.S812S	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Silent_p.S337S|CEP192_uc002kru.2_RNA|CEP192_uc002krs.1_Silent_p.S553S	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	812										ovary(4)|pancreas(1)	5						GGGATTTATCTTTGCCCAAAG	0.373000												
CTAGE1	64693	broad.mit.edu	37	18	19995611	19995611	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:19995611C>T	uc002ktv.1	-	1	2268	c.2164G>A	c.(2164-2166)GTC>ATC	p.V722I		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	722	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GGTAAATAGACATTTCTCATT	0.507000												
ZNF521	25925	broad.mit.edu	37	18	22806293	22806293	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:22806293T>C	uc002kvk.2	-	4	1836	c.1589A>G	c.(1588-1590)GAG>GGG	p.E530G	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.E530G|ZNF521_uc002kvl.2_Missense_Mutation_p.E310G	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	530	C2H2-type 12.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCTAATATGCTCTTCCAGGGA	0.458000			T	PAX5	ALL							
ZNF521	25925	broad.mit.edu	37	18	22806855	22806855	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:22806855T>C	uc002kvk.2	-	4	1274	c.1027A>G	c.(1027-1029)AGC>GGC	p.S343G	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S343G|ZNF521_uc002kvl.2_Missense_Mutation_p.S123G	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	343					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGGGAAGGGCTGTTGCTGTGA	0.547000			T	PAX5	ALL							
CELF4	56853	broad.mit.edu	37	18	34833871	34833871	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:34833871G>A	uc002lae.2	-	12	1760	c.1364C>T	c.(1363-1365)GCG>GTG	p.A455V	CELF4_uc010dnd.1_Missense_Mutation_p.A453V|CELF4_uc002lag.2_Missense_Mutation_p.A417V|CELF4_uc002laf.2_Missense_Mutation_p.A449V	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	455	RRM 3.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						GGCGGTCTGCGCGCTGGCCGG	0.532000												
SYT4	6860	broad.mit.edu	37	18	40854178	40854178	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:40854178C>A	uc002law.2	-	2	585	c.216G>T	c.(214-216)AAG>AAT	p.K72N	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.K54N|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	72	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						CTGCTCCAAACTTCTTTTTGC	0.363000												
KIAA1632	57724	broad.mit.edu	37	18	43510773	43510773	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:43510773C>T	uc002lbm.2	-	12	2381	c.2281G>A	c.(2281-2283)GAG>AAG	p.E761K	KIAA1632_uc002lbo.1_Missense_Mutation_p.E761K	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	761					autophagy						0						AGACACTTCTCAAAGTTGGTA	0.378000												
DCC	1630	broad.mit.edu	37	18	51013309	51013309	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:51013309C>T	uc002lfe.1	+	26	4466	c.3879C>T	c.(3877-3879)TTC>TTT	p.F1293F	DCC_uc010dpf.1_Silent_p.F928F	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1293	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		ACCGAGGTTTCGGAGCAGGAA	0.473000												
RNF152	220441	broad.mit.edu	37	18	59483266	59483266	+	Missense_Mutation	SNP	C	C	A	rs146480133		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:59483266C>A	uc002lih.1	-	2	843	c.431G>T	c.(430-432)GGT>GTT	p.G144V		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	144					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				GGGAGCCCCACCTTGCAGAGG	0.677000												
ZNF236	7776	broad.mit.edu	37	18	74620433	74620433	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr18:74620433G>A	uc002lmi.2	+	14	2647	c.2449G>A	c.(2449-2451)GAG>AAG	p.E817K	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	817					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		AGCGAACCCCGAGGCCATGCT	0.627000												
THEG	51298	broad.mit.edu	37	19	367066	367066	+	Silent	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:367066G>T	uc002lol.2	-	7	951	c.912C>A	c.(910-912)GCC>GCA	p.A304A	THEG_uc002lom.2_Silent_p.A280A	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Theg homolog isoform 1	304	THEG 5.				cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			ovary(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTACTTACTGGCCAAGTGAA	0.572000												
MKNK2	2872	broad.mit.edu	37	19	2043500	2043500	+	Splice_Site	SNP	A	A	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:2043500A>T	uc002lus.2	-	6	664	c.419_splice	c.e6+1	p.R140_splice	MKNK2_uc002luq.1_5'Flank|MKNK2_uc010xgu.1_Splice_Site|MKNK2_uc010xgv.1_Splice_Site_p.R9_splice|MKNK2_uc002lur.2_Splice_Site_p.R140_splice|MKNK2_uc002lut.1_5'Flank	NM_199054	NP_951009	Q9HBH9	MKNK2_HUMAN	MAP kinase-interacting serine/threonine kinase 2						cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(1)|breast(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCTCACCTACCTGTGTCCC	0.587000												
PIP5K1C	23396	broad.mit.edu	37	19	3656413	3656413	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:3656413C>A	uc002lyj.1	-	6	668	c.611G>T	c.(610-612)GGC>GTC	p.G204V	PIP5K1C_uc010xhq.1_Missense_Mutation_p.G204V|PIP5K1C_uc010xhr.1_Missense_Mutation_p.G204V	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	204	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CATGTAGTAGCCAGGGAGCAG	0.637000												
ZBTB7A	51341	broad.mit.edu	37	19	4047779	4047779	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:4047779C>T	uc002lzh.2	-	3	1801	c.1726G>A	c.(1726-1728)GAC>AAC	p.D576N	ZBTB7A_uc002lzi.2_Missense_Mutation_p.D576N	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	576					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGTTACCGTCGGTGGCGGCC	0.542000												
SAFB	6294	broad.mit.edu	37	19	5668283	5668283	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:5668283G>A	uc002mcf.2	+	21	2782	c.2729G>A	c.(2728-2730)CGC>CAC	p.R910H	SAFB_uc002mcg.2_Missense_Mutation_p.R912H|SAFB_uc002mce.3_Missense_Mutation_p.R911H|SAFB_uc010xir.1_Missense_Mutation_p.R909H|SAFB_uc010xis.1_Missense_Mutation_p.R843H|SAFB_uc010xit.1_Missense_Mutation_p.R754H|SAFB_uc010xiu.1_Missense_Mutation_p.R711H	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	910	Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		AGCGATGCCCGCTTCACTCGC	0.592000												
TUBB4	10382	broad.mit.edu	37	19	6495840	6495840	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:6495840C>A	uc002mfg.1	-	4	777	c.670G>T	c.(670-672)GAC>TAC	p.D224Y	TUBB4_uc002mff.1_Missense_Mutation_p.D152Y|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	224					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		TGGTTGAGGTCCCCGTAGGTG	0.627000												
C3	718	broad.mit.edu	37	19	6707206	6707206	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:6707206C>T	uc002mfm.2	-	17	2188	c.2126G>A	c.(2125-2127)CGC>CAC	p.R709H		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	709	Anaphylatoxin-like.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACGGGTCCGGCGCTGGCACGA	0.662000												
ZNF358	140467	broad.mit.edu	37	19	7584566	7584566	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:7584566C>T	uc002mgn.2	+	2	608	c.438C>T	c.(436-438)AGC>AGT	p.S146S	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	146					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						cccccgccagcccgccccggc	0.602000												
OR7D4	125958	broad.mit.edu	37	19	9325365	9325365	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:9325365C>T	uc002mla.1	-	1	149	c.149G>A	c.(148-150)AGC>AAC	p.S50N		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GGAGTCAGAGCTGACGGCCAG	0.547000												
ZNF85	7639	broad.mit.edu	37	19	21131694	21131694	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:21131694A>C	uc002npg.3	+	4	501	c.374A>C	c.(373-375)AAG>ACG	p.K125T	ZNF85_uc010ecn.2_Missense_Mutation_p.K60T|ZNF85_uc010eco.2_Missense_Mutation_p.K73T|ZNF85_uc002npi.2_Missense_Mutation_p.K66T	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	125						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						GATGAGTGTAAGATGCACAAA	0.323000												
ZNF208	7757	broad.mit.edu	37	19	22157195	22157195	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:22157195G>T	uc002nqp.2	-	4	790	c.641C>A	c.(640-642)TCA>TAA	p.S214*	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGTAAGGGTTGAGGACCAGTT	0.358000												
ZNF257	113835	broad.mit.edu	37	19	22271400	22271400	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:22271400A>C	uc010ecx.2	+	4	1017	c.848A>C	c.(847-849)AAG>ACG	p.K283T	ZNF257_uc010ecy.2_Missense_Mutation_p.K251T	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				AATAGAGAGAAGCCCTTCAAA	0.388000												
ZNF790	388536	broad.mit.edu	37	19	37310610	37310610	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:37310610T>G	uc002oew.2	-	5	755	c.636A>C	c.(634-636)GAA>GAC	p.E212D	uc002oev.1_Intron	NM_206894	NP_996777	Q6PG37	ZN790_HUMAN	zinc finger protein 790	212	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ATTGAATAACTTCTGAATCAG	0.338000												
ZNF296	162979	broad.mit.edu	37	19	45575376	45575376	+	Missense_Mutation	SNP	G	G	A	rs143888878		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:45575376G>A	uc002pao.2	-	3	968	c.911C>T	c.(910-912)CCG>CTG	p.P304L		NM_145288	NP_660331	Q8WUU4	ZN296_HUMAN	zinc finger protein 296	304					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGCCGGCTCCGGAGGGGCTGC	0.706000												
PRR12	57479	broad.mit.edu	37	19	50098208	50098208	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:50098208G>A	uc002poo.3	+	4	616	c.616G>A	c.(616-618)GAG>AAG	p.E206K		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		ACTGGGCTTCGAGCGCCTGGC	0.701000												
NR1H2	7376	broad.mit.edu	37	19	50885722	50885722	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:50885722C>T	uc010enw.2	+	11	1525	c.1249C>T	c.(1249-1251)CGC>TGC	p.R417C	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Missense_Mutation_p.R372C|NR1H2_uc002psa.3_Missense_Mutation_p.R319C|POLD1_uc002psb.3_5'Flank|POLD1_uc002psc.3_5'Flank|POLD1_uc010enx.2_5'Flank	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	416	Ligand-binding (Potential).				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GGACCAGCTGCGCTTCCCGCG	0.677000												
ZNF615	284370	broad.mit.edu	37	19	52497583	52497583	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:52497583T>C	uc002pye.1	-	6	1038	c.746A>G	c.(745-747)GAC>GGC	p.D249G	ZNF615_uc002pyf.1_Missense_Mutation_p.D260G|ZNF615_uc002pyg.1_Missense_Mutation_p.D141G|ZNF615_uc002pyh.1_Missense_Mutation_p.D260G|ZNF615_uc010epi.1_Missense_Mutation_p.D256G|ZNF615_uc010ydg.1_Missense_Mutation_p.D254G	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	249	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TCTCTGATGGTCCATTAGTCT	0.378000												
ZNF606	80095	broad.mit.edu	37	19	58491010	58491010	+	Silent	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr19:58491010A>G	uc002qqw.2	-	7	1656	c.1038T>C	c.(1036-1038)AAT>AAC	p.N346N	ZNF606_uc010yhp.1_Silent_p.N256N	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		ATTCTTTGTAATTATACTGGT	0.323000												
KCNK3	3777	broad.mit.edu	37	2	26950835	26950835	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:26950835T>C	uc002rhn.2	+	2	747	c.584T>C	c.(583-585)ATC>ACC	p.I195T		NM_002246	NP_002237	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	195					synaptic transmission	integral to plasma membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACTGCTTCATCACCCTCACC	0.612000												
SLC8A1	6546	broad.mit.edu	37	2	40657239	40657239	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:40657239A>G	uc002rrx.2	-	1	206	c.182T>C	c.(181-183)TTG>TCG	p.L61S	SLC8A1_uc002rry.2_Missense_Mutation_p.L61S|SLC8A1_uc002rrz.2_Missense_Mutation_p.L61S|SLC8A1_uc002rsa.2_Missense_Mutation_p.L61S|SLC8A1_uc002rsd.3_Missense_Mutation_p.L61S|SLC8A1_uc002rsb.1_Missense_Mutation_p.L61S|SLC8A1_uc010fan.1_Missense_Mutation_p.L61S|SLC8A1_uc002rsc.1_Missense_Mutation_p.L61S	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	61	Extracellular (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CCAAATGGGCAAAATCACCCC	0.428000												
PREPL	9581	broad.mit.edu	37	2	44554027	44554027	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:44554027G>A	uc002ruf.2	-	10	1605	c.1570C>T	c.(1570-1572)CGC>TGC	p.R524C	PREPL_uc002rug.2_Missense_Mutation_p.R458C|PREPL_uc002ruh.2_Missense_Mutation_p.R462C|PREPL_uc010fax.2_Missense_Mutation_p.R524C|PREPL_uc002rui.3_Missense_Mutation_p.R435C|PREPL_uc002ruj.1_Missense_Mutation_p.R435C|PREPL_uc002ruk.1_Missense_Mutation_p.R524C	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	524					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TTAGTTAGGCGGCCATCAGCG	0.453000												
PNPT1	87178	broad.mit.edu	37	2	55920812	55920812	+	Silent	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:55920812C>G	uc002rzf.2	-	1	200	c.147G>C	c.(145-147)GTG>GTC	p.V49V	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	49					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGCCTAAGTCCACGGCCACAG	0.562000												
KRCC1	51315	broad.mit.edu	37	2	88327339	88327339	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:88327339C>T	uc002sso.1	-	4	1138	c.744G>A	c.(742-744)GAG>GAA	p.E248E	KRCC1_uc002ssp.1_Silent_p.E248E	NM_016618	NP_057702	Q9NPI7	KRCC1_HUMAN	lysine-rich coiled-coil 1	248	Potential.									ovary(1)	1						AAAGCATTTCCTCCTCTGTCC	0.378000												
LMAN2L	81562	broad.mit.edu	37	2	97400258	97400258	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:97400258A>T	uc002swu.2	-	3	348	c.312T>A	c.(310-312)TGT>TGA	p.C104*	LMAN2L_uc002swv.2_Nonsense_Mutation_p.C104*|LMAN2L_uc010yut.1_5'UTR|LMAN2L_uc010yuu.1_5'UTR|LMAN2L_uc010yuv.1_5'UTR|LMAN2L_uc010yuw.1_5'UTR|LMAN2L_uc002sww.2_5'UTR|LMAN2L_uc010yux.1_5'UTR	NM_030805	NP_110432	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like isoform 2	104	L-type lectin-like.|Lumenal (Potential).				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding				0						CTCTCAGGAAACATGGCTAAA	0.443000												
C2orf55	343990	broad.mit.edu	37	2	99439596	99439596	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:99439596C>T	uc002szf.1	-	7	1434	c.1140G>A	c.(1138-1140)CCG>CCA	p.P380P		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	380	Pro-rich.										0						CCGGGGCACACGGGCCTGCGG	0.751000												
EDAR	10913	broad.mit.edu	37	2	109524386	109524386	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:109524386G>A	uc002teq.3	-	10	1324	c.893C>T	c.(892-894)CCG>CTG	p.P298L	EDAR_uc010fjn.2_Missense_Mutation_p.P330L|EDAR_uc010yws.1_Missense_Mutation_p.P330L	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	298	Cytoplasmic (Potential).				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1						GCACAGCTCCGGGGAGCCCTG	0.622000												
ACOXL	55289	broad.mit.edu	37	2	111542390	111542390	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:111542390A>G	uc002tgr.3	+	3	381	c.157A>G	c.(157-159)AAG>GAG	p.K53E	ACOXL_uc010fkc.2_Missense_Mutation_p.K53E|ACOXL_uc010yxk.1_Missense_Mutation_p.K53E	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	53					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						CACAGGAGTGAAGGTGAGAGG	0.498000												
GPR148	344561	broad.mit.edu	37	2	131486823	131486823	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:131486823C>A	uc002trv.1	+	1	101	c.99C>A	c.(97-99)AGC>AGA	p.S33R		NM_207364	NP_997247	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	33	Extracellular (Potential).			CMPQAASNTSLGLGDLRVPSSMLYWLFLPSSLLAAA -> S S (in Ref. 2; AAP34196).		integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1	Colorectal(110;0.1)					AAGCAGCCAGCAACACTTCCT	0.627000												
THSD7B	80731	broad.mit.edu	37	2	137852666	137852666	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:137852666G>A	uc002tva.1	+	3	1081	c.1081G>A	c.(1081-1083)GGA>AGA	p.G361R	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.G251R	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CATTGTTGAAGGAGAACTTCT	0.448000												
LRP1B	53353	broad.mit.edu	37	2	141299347	141299347	+	Splice_Site	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:141299347C>A	uc002tvj.1	-	44	8359	c.7387_splice	c.e44+1	p.C2463_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTATAACTTACAGCTATTGGT	0.338000										TSP Lung(27;0.18)		
BAZ2B	29994	broad.mit.edu	37	2	160295025	160295025	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:160295025G>A	uc002uao.2	-	8	1434	c.1082C>T	c.(1081-1083)TCT>TTT	p.S361F	BAZ2B_uc002uap.2_Missense_Mutation_p.S359F|BAZ2B_uc002uas.1_Missense_Mutation_p.S298F|BAZ2B_uc002uau.1_Missense_Mutation_p.S359F|BAZ2B_uc002uaq.1_Missense_Mutation_p.S289F|BAZ2B_uc002uat.3_3'UTR|BAZ2B_uc010fop.1_Missense_Mutation_p.S359F	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTTTGCCTGAGAGCTTTGGAA	0.443000												
TTN	7273	broad.mit.edu	37	2	179398461	179398461	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:179398461G>T	uc010zfg.1	-	307	95401	c.95177C>A	c.(95176-95178)TCA>TAA	p.S31726*	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Nonsense_Mutation_p.S25421*|TTN_uc010zfi.1_Nonsense_Mutation_p.S25354*|TTN_uc010zfj.1_Nonsense_Mutation_p.S25229*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32653							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTGACCTGATTTATACCA	0.398000												
TTN	7273	broad.mit.edu	37	2	179443586	179443586	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:179443586T>C	uc010zfg.1	-	269	60691	c.60467A>G	c.(60466-60468)TAT>TGT	p.Y20156C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Y13851C|TTN_uc010zfi.1_Missense_Mutation_p.Y13784C|TTN_uc010zfj.1_Missense_Mutation_p.Y13659C|uc002umv.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21083							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTACACCATATTTATTTTC	0.458000												
HECW2	57520	broad.mit.edu	37	2	197185083	197185083	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:197185083A>C	uc002utm.1	-	8	1148	c.965T>G	c.(964-966)GTT>GGT	p.V322G	HECW2_uc002utl.1_Intron	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	322					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						AGAAGACGTAACCTCCACTTT	0.408000												
ALS2CR12	130540	broad.mit.edu	37	2	202208958	202208958	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:202208958G>T	uc010ftg.2	-	6	841	c.397C>A	c.(397-399)CAA>AAA	p.Q133K	ALS2CR12_uc002uya.3_Missense_Mutation_p.Q133K|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	133	Potential.				regulation of GTPase activity		protein binding	p.Q133H(1)		ovary(1)|breast(1)|central_nervous_system(1)	3						TCTGAGATTTGCTCTTCTAGG	0.433000												
CRYGD	1421	broad.mit.edu	37	2	208988868	208988868	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:208988868C>T	uc002vcn.3	-	2	336	c.220G>A	c.(220-222)GAC>AAC	p.D74N		NM_006891	NP_008822	P07320	CRGD_HUMAN	crystallin, gamma D	74	Beta/gamma crystallin 'Greek key' 2.				cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		CGGACCGAGTCGCTGAGGCCC	0.612000												
ERBB4	2066	broad.mit.edu	37	2	212251789	212251789	+	Silent	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:212251789T>C	uc002veg.1	-	27	3368	c.3270A>G	c.(3268-3270)GAA>GAG	p.E1090E	ERBB4_uc002veh.1_Silent_p.E1074E|ERBB4_uc010zji.1_Silent_p.E1080E|ERBB4_uc010zjj.1_Silent_p.E1064E	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1090	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CCACAGGAGCTTCTGGAATTG	0.502000										TSP Lung(8;0.080)		
CRYBA2	1412	broad.mit.edu	37	2	219856890	219856890	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:219856890G>A	uc002vjj.1	-	3	272	c.237C>T	c.(235-237)AGC>AGT	p.S79S	CRYBA2_uc002vjk.1_Silent_p.S79S	NM_057094	NP_476435	P53672	CRBA2_HUMAN	crystallin, beta A2	79	Beta/gamma crystallin 'Greek key' 2.						structural constituent of eye lens				0		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACTCCAGGCGCTCCAGCGAG	0.612000												
DNER	92737	broad.mit.edu	37	2	230223363	230223363	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:230223363C>A	uc002vpv.2	-	13	2254	c.2107G>T	c.(2107-2109)GGA>TGA	p.G703*		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	703	Cytoplasmic (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		GATTTCTTTCCAAACCTGAAA	0.363000												
SP100	6672	broad.mit.edu	37	2	231371021	231371021	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:231371021C>A	uc002vqt.2	+	22	2015	c.1874C>A	c.(1873-1875)ACC>AAC	p.T625N	SP100_uc002vqs.2_Missense_Mutation_p.T625N|SP100_uc002vqu.1_Missense_Mutation_p.T625N|SP100_uc010fxp.1_5'UTR	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	625	SAND.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CTTACAGGAACCTCAAAGAAG	0.507000												
ANO7	50636	broad.mit.edu	37	2	242155602	242155602	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr2:242155602G>A	uc002wax.2	+	19	2186	c.2083G>A	c.(2083-2085)GAC>AAC	p.D695N		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	695	Extracellular (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CTGGGAGGACGACTATGAGCT	0.627000												
C20orf160	140706	broad.mit.edu	37	20	30602748	30602748	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr20:30602748C>T	uc002wxf.2	+	2	85	c.72C>T	c.(70-72)GCC>GCT	p.A24A		NM_080625	NP_542192	Q9NUG4	CT160_HUMAN	hypothetical protein LOC140706	24										central_nervous_system(3)|ovary(1)	4						TCCCCAAGGCCGGGCGCCGGG	0.582000												
BLCAP	10904	broad.mit.edu	37	20	36147344	36147344	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr20:36147344G>A	uc002xha.2	-	2	436	c.233C>T	c.(232-234)TCG>TTG	p.S78L	BLCAP_uc002xhb.2_Missense_Mutation_p.S78L|BLCAP_uc002xhc.2_Missense_Mutation_p.S78L|NNAT_uc002xhd.2_5'Flank|NNAT_uc002xhe.2_5'Flank	NM_006698	NP_006689	P62952	BLCAP_HUMAN	bladder cancer associated protein	78					apoptosis|cell cycle	integral to membrane					0		Myeloproliferative disorder(115;0.00878)				ATCATGCGCCGATTCTGGAAG	0.547000												
SPINLW1	57119	broad.mit.edu	37	20	44174305	44174305	+	Missense_Mutation	SNP	C	C	T	rs112762127	byFrequency	TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr20:44174305C>T	uc002xou.2	-	2	228	c.196G>A	c.(196-198)GGA>AGA	p.G66R	SPINLW1_uc010zxc.1_Missense_Mutation_p.G66R|SPINLW1_uc002xot.2_Missense_Mutation_p.G50R|SPINLW1_uc002xov.1_Missense_Mutation_p.G66R	NM_020398	NP_065131	O95925	EPPI_HUMAN	serine peptidase inhibitor-like, with Kunitz and	66	WAP.					extracellular region	serine-type endopeptidase inhibitor activity			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)				CATTTTTTTCCGCAGCTGAAG	0.448000												
KCNG1	3755	broad.mit.edu	37	20	49626481	49626481	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr20:49626481C>T	uc002xwa.3	-	2	690	c.395G>A	c.(394-396)CGC>CAC	p.R132H	KCNG1_uc002xwb.2_Missense_Mutation_p.R132H	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	132	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						CTTGCCCGCGCGCAGGAAGGT	0.647000												
TMPRSS15	5651	broad.mit.edu	37	21	19653531	19653531	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr21:19653531A>C	uc002ykw.2	-	22	2525	c.2494T>G	c.(2494-2496)TTA>GTA	p.L832V		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	832	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						GATGGCTCTAAGTTTCTCCTG	0.373000												
TIAM1	7074	broad.mit.edu	37	21	32493119	32493119	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr21:32493119C>T	uc002yow.1	-	29	4815	c.4343G>A	c.(4342-4344)CGG>CAG	p.R1448Q	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Missense_Mutation_p.R1388Q	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1448	Poly-Arg.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						AGCCAGCCGCCGCCTCCTCCT	0.537000												
RFPL1	5988	broad.mit.edu	37	22	29837692	29837692	+	Missense_Mutation	SNP	C	C	T	rs142632131	byFrequency	TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr22:29837692C>T	uc003afn.2	+	2	744	c.535C>T	c.(535-537)CGC>TGC	p.R179C	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	179	B30.2/SPRY.						zinc ion binding				0						TACCTGTGGCCGCCACTACTG	0.567000												
SUMF1	285362	broad.mit.edu	37	3	4494657	4494657	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:4494657G>A	uc003bpz.1	-	2	372	c.347C>T	c.(346-348)GCG>GTG	p.A116V	SUMF1_uc003bps.1_RNA|SUMF1_uc011ass.1_Missense_Mutation_p.A116V|SUMF1_uc010hby.1_Missense_Mutation_p.A116V|SUMF1_uc011ast.1_Missense_Mutation_p.A116V	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1	116						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		AACTCTCCTCGCAGGTGCTTC	0.438000												
ARPP21	10777	broad.mit.edu	37	3	35778739	35778739	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:35778739G>A	uc003cgb.2	+	16	1793	c.1529G>A	c.(1528-1530)CGA>CAA	p.R510Q	ARPP21_uc003cga.2_Missense_Mutation_p.R456Q|ARPP21_uc011axy.1_Missense_Mutation_p.R476Q|ARPP21_uc003cgf.2_Missense_Mutation_p.R311Q|ARPP21_uc003cgg.2_5'UTR	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	510	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CAGCCCCTGCGAAGCGCCATG	0.612000												
XIRP1	165904	broad.mit.edu	37	3	39229243	39229243	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:39229243C>T	uc003cjk.1	-	2	1915	c.1694G>A	c.(1693-1695)CGG>CAG	p.R565Q	XIRP1_uc003cji.2_Missense_Mutation_p.R565Q|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	565	Interaction with CTNNB1 (By similarity).						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CTGCTGCTCCCGTTGGTGGAT	0.622000												
RHOA	387	broad.mit.edu	37	3	49412900	49412900	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:49412900G>C	uc003cwu.2	-	2	399	c.123C>G	c.(121-123)AAC>AAG	p.N41K	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	41	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	CTGCCACATAGTTCTCAAACA	0.438000												
AMIGO3	386724	broad.mit.edu	37	3	49756171	49756171	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:49756171C>T	uc003cxj.2	-	1	1068	c.728G>A	c.(727-729)CGC>CAC	p.R243H	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	243	Extracellular (Potential).|LRRCT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CGCAAAGTCGCGCACGGCGCT	0.637000												
PBRM1	55193	broad.mit.edu	37	3	52702550	52702550	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:52702550G>A	uc003des.2	-	3	360	c.348C>T	c.(346-348)TTC>TTT	p.F116F	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Silent_p.F116F|PBRM1_uc003der.2_Silent_p.F116F|PBRM1_uc003det.2_Silent_p.F116F|PBRM1_uc003deu.2_Silent_p.F116F|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Silent_p.F116F|PBRM1_uc010hmk.1_Silent_p.F116F|PBRM1_uc003dey.2_Silent_p.F116F|PBRM1_uc003dez.1_Silent_p.F116F|PBRM1_uc003dfb.1_Silent_p.F14F	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	116	Bromo 1.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AAAGAAGCTGGAAGTCAGCAG	0.303000			Mis|N|F|S|D|O		clear cell renal carcinoma|breast							
C3orf64	285203	broad.mit.edu	37	3	69028852	69028852	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:69028852A>C	uc003dnl.2	-	16	1706	c.1301T>G	c.(1300-1302)CTT>CGT	p.L434R	C3orf64_uc003dnj.2_Missense_Mutation_p.L113R|C3orf64_uc003dnk.2_Missense_Mutation_p.L350R|C3orf64_uc011bfw.1_RNA	NM_173654	NP_775925	Q5NDL2	AER61_HUMAN	AER61 glycosyltransferase	434						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)		TGGAAGGAAAAGTAAATGGGT	0.408000												
ZPLD1	131368	broad.mit.edu	37	3	102187912	102187912	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:102187912T>A	uc003dvs.1	+	15	1748	c.866T>A	c.(865-867)ATG>AAG	p.M289K	ZPLD1_uc003dvt.1_Missense_Mutation_p.M305K|ZPLD1_uc011bhg.1_Missense_Mutation_p.M289K	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	289	ZP.|Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						AATCAGAAAATGTCCACTGTC	0.468000												
BBX	56987	broad.mit.edu	37	3	107474490	107474490	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:107474490C>T	uc010hpr.2	+	10	1198	c.871C>T	c.(871-873)CGC>TGC	p.R291C	BBX_uc003dwk.3_Missense_Mutation_p.R291C|BBX_uc003dwl.3_Missense_Mutation_p.R291C|BBX_uc010hps.1_Missense_Mutation_p.R312C|BBX_uc003dwm.3_Missense_Mutation_p.R291C	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GCCTGTAAAACGCTGTGGAAA	0.383000												
BOC	91653	broad.mit.edu	37	3	113002434	113002434	+	Missense_Mutation	SNP	G	G	A	rs116501937	by1000genomes	TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:113002434G>A	uc003dzx.2	+	16	3229	c.2608G>A	c.(2608-2610)GTC>ATC	p.V870I	BOC_uc003dzy.2_Missense_Mutation_p.V870I|BOC_uc003dzz.2_Missense_Mutation_p.V871I|BOC_uc003eab.2_Missense_Mutation_p.V571I|BOC_uc003eac.2_Missense_Mutation_p.V185I	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	870	Helical; (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			TCTCATCATCGTCACCTTCAT	0.607000												
TIGIT	201633	broad.mit.edu	37	3	114014537	114014537	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:114014537T>G	uc003ebg.1	+	2	241	c.207T>G	c.(205-207)TGT>TGG	p.C69W		NM_173799	NP_776160	Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	69	Extracellular (Potential).|Ig-like V-type.				negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)	1						TGGCCATTTGTAATGCTGACT	0.577000												
NPHP3	27031	broad.mit.edu	37	3	132418811	132418811	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:132418811C>T	uc003epe.1	-	12	1915	c.1838G>A	c.(1837-1839)CGT>CAT	p.R613H	NPHP3_uc003epd.1_5'UTR|NPHP3_uc003epf.1_Missense_Mutation_p.R368H	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	613					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						GCCTTGATGACGAGCAGAGAG	0.418000												
SLCO2A1	6578	broad.mit.edu	37	3	133653654	133653654	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:133653654C>T	uc003eqa.3	-	14	2109	c.1835G>A	c.(1834-1836)GGC>GAC	p.G612D	SLCO2A1_uc003eqb.3_Missense_Mutation_p.G536D	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family,	612	Helical; Name=12; (Potential).				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			central_nervous_system(1)	1						CGCCTTGTAGCCCATCTGCAG	0.622000												
MED12L	116931	broad.mit.edu	37	3	150877793	150877793	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:150877793G>A	uc003eyp.2	+	7	1050	c.1012G>A	c.(1012-1014)GGC>AGC	p.G338S	MED12L_uc011bnz.1_Intron|MED12L_uc003eyn.2_Missense_Mutation_p.G338S|MED12L_uc003eyo.2_Missense_Mutation_p.G338S	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	338					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGGCCCCCCCGGCCCTGGCAT	0.587000												
MED12L	116931	broad.mit.edu	37	3	151095885	151095885	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:151095885G>T	uc003eyp.2	+	29	4335	c.4297G>T	c.(4297-4299)GCT>TCT	p.A1433S	MED12L_uc011bnz.1_Missense_Mutation_p.A1293S|P2RY12_uc011boa.1_Intron|P2RY12_uc003eyx.1_Intron|MED12L_uc003eyy.1_Missense_Mutation_p.A596S	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1433					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCTGAAAGCCGCTGGGGAAGA	0.532000												
SCHIP1	29970	broad.mit.edu	37	3	159614519	159614519	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:159614519G>T	uc003fcs.1	+	8	1486	c.1420G>T	c.(1420-1422)GAA>TAA	p.E474*	SCHIP1_uc003fcq.1_Nonsense_Mutation_p.E550*|SCHIP1_uc003fcr.1_Nonsense_Mutation_p.E463*|SCHIP1_uc003fct.1_Nonsense_Mutation_p.E461*|SCHIP1_uc003fcu.1_Nonsense_Mutation_p.E231*|SCHIP1_uc003fcv.1_Nonsense_Mutation_p.E247*	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	474						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			CAGACATGCTGAAAGTCAGCA	0.373000												
ZBBX	79740	broad.mit.edu	37	3	167083738	167083738	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:167083738C>T	uc003fep.2	-	6	532	c.209G>A	c.(208-210)GGA>GAA	p.G70E	ZBBX_uc011bpc.1_Missense_Mutation_p.G70E|ZBBX_uc003feq.2_Missense_Mutation_p.G41E	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	70						intracellular	zinc ion binding			ovary(2)	2						GCCCACTTTTCCAGATTTCCA	0.289000												
LRRC31	79782	broad.mit.edu	37	3	169557820	169557820	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:169557820C>T	uc003fgc.1	-	9	1686	c.1609G>A	c.(1609-1611)GAC>AAC	p.D537N	LRRC31_uc010hwp.1_Missense_Mutation_p.D481N	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	537										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TTATCTTGGTCAAAGCATTCT	0.403000												
IL1RAP	3556	broad.mit.edu	37	3	190338192	190338192	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr3:190338192G>A	uc003fsm.1	+	6	872	c.666G>A	c.(664-666)ACG>ACA	p.T222T	IL1RAP_uc003fsk.2_Silent_p.T222T|IL1RAP_uc003fsl.2_Silent_p.T222T|IL1RAP_uc010hzf.2_Silent_p.T81T|IL1RAP_uc010hzg.1_Silent_p.T222T|IL1RAP_uc003fsn.1_RNA|IL1RAP_uc003fso.1_Silent_p.T222T|IL1RAP_uc003fsp.1_RNA|IL1RAP_uc003fsq.2_Silent_p.T222T	NM_002182	NP_002173	Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein isoform	222	Extracellular (Potential).|Ig-like C2-type 2.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		ATGGACGTACGTTTCATCTCA	0.363000												
ZBTB49	166793	broad.mit.edu	37	4	4304670	4304670	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr4:4304670C>T	uc003ghu.2	+	3	1282	c.1107C>T	c.(1105-1107)TGC>TGT	p.C369C	ZBTB49_uc003ghv.2_5'UTR|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Silent_p.C69C	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ATTTTAATTGCATTAGTGAGA	0.468000												
SULT1E1	6783	broad.mit.edu	37	4	70723267	70723267	+	Silent	SNP	C	C	T	rs138937330		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr4:70723267C>T	uc003heo.2	-	2	209	c.96G>A	c.(94-96)GCG>GCA	p.A32A	SULT1E1_uc010ihv.1_Silent_p.A32A	NM_005420	NP_005411	P49888	ST1E1_HUMAN	estrogen sulfotransferase	32					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			ovary(1)	1						TTGCCTGGAACGCTTCCACAT	0.348000												
PCDH18	54510	broad.mit.edu	37	4	138452262	138452262	+	Silent	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr4:138452262T>C	uc003ihe.3	-	1	1368	c.981A>G	c.(979-981)CAA>CAG	p.Q327Q	PCDH18_uc003ihf.3_Silent_p.Q320Q|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Silent_p.Q107Q|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	327	Cadherin 3.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GACCCAAATCTTGAGCCTGAA	0.353000												
WDR17	116966	broad.mit.edu	37	4	177082116	177082116	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr4:177082116T>A	uc003iuj.2	+	21	2941	c.2785T>A	c.(2785-2787)TCA>ACA	p.S929T	WDR17_uc003iuk.2_Missense_Mutation_p.S905T|WDR17_uc003ium.3_Missense_Mutation_p.S905T|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.S148T	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	929										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TAAAGGAGCTTCATATTCTGA	0.343000												
SEMA5A	9037	broad.mit.edu	37	5	9044528	9044528	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:9044528T>G	uc003jek.2	-	22	3774	c.3062A>C	c.(3061-3063)CAC>CCC	p.H1021P		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	1021	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TTTGTTGATGTGGTTGGTTAT	0.488000												
CDH10	1008	broad.mit.edu	37	5	24487971	24487971	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:24487971A>G	uc003jgr.1	-	12	2500	c.2168T>C	c.(2167-2169)CTT>CCT	p.L723P	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	723	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GGTGGGGTCAAGATCATGCTC	0.443000										HNSCC(23;0.051)		
ADAMTS12	81792	broad.mit.edu	37	5	33614400	33614400	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:33614400G>T	uc003jia.1	-	16	2633	c.2470C>A	c.(2470-2472)CAG>AAG	p.Q824K	ADAMTS12_uc010iuq.1_Missense_Mutation_p.Q739K	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	824	TSP type-1 2.|Spacer 1.			Missing (in Ref. 1; CAC20419).	proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AAGTACATCTGCTGCTCAACA	0.512000										HNSCC(64;0.19)		
RXFP3	51289	broad.mit.edu	37	5	33936965	33936965	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:33936965C>T	uc003jic.1	+	1	477	c.120C>T	c.(118-120)AAC>AAT	p.N40N		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	40	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						CGAGTGGTAACGCGTCGCTGC	0.667000												
ITGA1	3672	broad.mit.edu	37	5	52229783	52229783	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:52229783A>G	uc003jou.2	+	23	2973	c.2921A>G	c.(2920-2922)AAT>AGT	p.N974S	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.N505S	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	974	Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GAAGTTATTAATTCTACTGAG	0.269000												
VCAN	1462	broad.mit.edu	37	5	82837805	82837805	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:82837805A>C	uc003kii.3	+	8	9339	c.8983A>C	c.(8983-8985)AGT>CGT	p.S2995R	VCAN_uc003kij.3_Missense_Mutation_p.S2008R|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.S1659R	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2995	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GCCTTGGCTAAGTCCACAGAC	0.502000												
FAM81B	153643	broad.mit.edu	37	5	94749783	94749783	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:94749783C>G	uc003kla.1	+	4	472	c.426C>G	c.(424-426)TGC>TGG	p.C142W	FAM81B_uc010jbe.1_5'UTR	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	142										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		TCTCTGCTTGCCTGCAGGGGA	0.527000												
ADAMTS19	171019	broad.mit.edu	37	5	129039996	129039996	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:129039996A>C	uc003kvb.1	+	21	3206	c.3206A>C	c.(3205-3207)AAG>ACG	p.K1069T	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1069	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CCAAGAAAGAAGTGTGTCCTC	0.458000												
RAPGEF6	51735	broad.mit.edu	37	5	130825266	130825266	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:130825266C>G	uc003kvn.1	-	15	2019	c.1813G>C	c.(1813-1815)GCA>CCA	p.A605P	RAPGEF6_uc003kvp.1_Missense_Mutation_p.A655P|RAPGEF6_uc003kvo.1_Missense_Mutation_p.A605P|RAPGEF6_uc010jdi.1_Missense_Mutation_p.A605P|RAPGEF6_uc010jdj.1_Missense_Mutation_p.A605P|RAPGEF6_uc003kvq.2_Missense_Mutation_p.A322P|RAPGEF6_uc003kvr.2_Missense_Mutation_p.A605P|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.A605P	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	605	PDZ.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		ACAGTAAGTGCAAGATGAGTA	0.289000												
SPOCK1	6695	broad.mit.edu	37	5	136324155	136324155	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:136324155T>G	uc003lbo.2	-	7	1075	c.884A>C	c.(883-885)AAG>ACG	p.K295T	SPOCK1_uc003lbp.2_Missense_Mutation_p.K295T	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	295					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTAGAAAGCTTGCCATCCTT	0.532000												
HNRNPA0	10949	broad.mit.edu	37	5	137088877	137088877	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:137088877G>A	uc003lbt.2	-	1	1163	c.879C>T	c.(877-879)GGC>GGT	p.G293G	MYOT_uc011cye.1_Intron|HNRNPA0_uc010jeo.2_RNA	NM_006805	NP_006796	Q13151	ROA0_HUMAN	heterogeneous nuclear ribonucleoprotein A0	293	Gly-rich.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|RNA binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CACCGCCATAGCCGCCTCTGT	0.468000												
CDC25C	995	broad.mit.edu	37	5	137661584	137661584	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:137661584G>C	uc003lcp.1	-	6	650	c.379C>G	c.(379-381)CTT>GTT	p.L127V	CDC25C_uc003lcq.1_Intron|CDC25C_uc003lcr.1_Missense_Mutation_p.L127V|CDC25C_uc011cyp.1_Missense_Mutation_p.L144V|CDC25C_uc003lcs.1_Missense_Mutation_p.L205V|CDC25C_uc010jet.1_Intron|CDC25C_uc003lct.1_Intron|CDC25C_uc003lcu.1_Missense_Mutation_p.L84V	NM_001790	NP_001781	P30307	MPIP3_HUMAN	cell division cycle 25C isoform a	127					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			lung(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GTGCTACAAAGAAGCTGTGCC	0.443000												
PCDHA8	56140	broad.mit.edu	37	5	140222910	140222910	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:140222910G>A	uc003lhs.2	+	1	2004	c.2004G>A	c.(2002-2004)TCG>TCA	p.S668S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.S668S	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	668	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGGTGTCGCTGGTGGAGA	0.637000												
PCDHB16	57717	broad.mit.edu	37	5	140562740	140562740	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:140562740G>A	uc003liv.2	+	1	1761	c.606G>A	c.(604-606)CGG>CGA	p.R202R	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	202	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCTGGATCGGGAGGAGGAGC	0.498000												
ADAM19	8728	broad.mit.edu	37	5	156929870	156929870	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr5:156929870G>A	uc003lwz.2	-	12	1313	c.1249C>T	c.(1249-1251)CGG>TGG	p.R417W	ADAM19_uc003lww.1_Missense_Mutation_p.R150W|ADAM19_uc003lwy.2_Missense_Mutation_p.R16W|ADAM19_uc011ddr.1_Missense_Mutation_p.R348W	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	417	Disintegrin.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCACACCTCCGGCCTCCATAC	0.537000												
SOX4	6659	broad.mit.edu	37	6	21595667	21595667	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:21595667G>A	uc003ndi.2	+	1	1696	c.902G>A	c.(901-903)GGC>GAC	p.G301D		NM_003107	NP_003098	Q06945	SOX4_HUMAN	SRY (sex determining region Y)-box 4	301					canonical Wnt receptor signaling pathway|cardiac ventricle formation|cellular response to glucose stimulus|DNA damage response, detection of DNA damage|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|glial cell development|glial cell proliferation|limb bud formation|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein export from nucleus|negative regulation of protein ubiquitination|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|positive regulation of insulin secretion|positive regulation of N-terminal peptidyl-lysine acetylation|positive regulation of translation|pro-B cell differentiation|protein stabilization|skeletal system development|spinal cord motor neuron differentiation|sympathetic nervous system development|T cell differentiation	mitochondrion|nucleus	core promoter sequence-specific DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity				0	Ovarian(93;0.163)		all cancers(50;0.0751)|Epithelial(50;0.155)			CTGTTCGGCGGCCTGGGCACG	0.766000												
ZNF165	7718	broad.mit.edu	37	6	28057156	28057156	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:28057156T>A	uc003nkg.2	+	5	2450	c.1366T>A	c.(1366-1368)TAT>AAT	p.Y456N	ZNF165_uc003nkh.2_Missense_Mutation_p.Y456N|ZNF165_uc003nki.3_Missense_Mutation_p.Y456N|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	456	C2H2-type 6.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGAAAAACCCTATGAATGCAG	0.428000												
MDC1	9656	broad.mit.edu	37	6	30680604	30680604	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:30680604C>G	uc003nrg.3	-	5	1555	c.1115G>C	c.(1114-1116)AGC>ACC	p.S372T	MDC1_uc003nrf.3_Missense_Mutation_p.S26T|MDC1_uc011dmp.1_Missense_Mutation_p.S244T|MDC1_uc003nrh.1_Missense_Mutation_p.S244T|MDC1_uc003nri.2_Missense_Mutation_p.S372T	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	372	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						ACCAGCCTGGCTCTCCTGCAG	0.537000								Other_conserved_DNA_damage_response_genes				
DOM3Z	1797	broad.mit.edu	37	6	31938737	31938737	+	Missense_Mutation	SNP	G	G	A	rs147759642		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:31938737G>A	uc003nyo.1	-	2	1078	c.544C>T	c.(544-546)CGG>TGG	p.R182W	DOM3Z_uc003nyp.1_Missense_Mutation_p.R182W|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_Missense_Mutation_p.R182W|DOM3Z_uc003nys.1_Missense_Mutation_p.R182W|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	182							identical protein binding|metal ion binding|nucleotide binding				0						ATAAGCTCCCGGAGGAGCGGT	0.592000												
PTK7	5754	broad.mit.edu	37	6	43096749	43096749	+	Silent	SNP	G	G	A	rs151242533		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:43096749G>A	uc003oub.1	+	2	312	c.114G>A	c.(112-114)CCG>CCA	p.P38P	PTK7_uc003ouc.1_Silent_p.P38P|PTK7_uc003oud.1_Silent_p.P38P|PTK7_uc003oue.1_Silent_p.P38P|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Silent_p.P46P|PTK7_uc003oua.2_Silent_p.P38P	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	38	Ig-like C2-type 1.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			TCAAGCAGCCGTCCTCCCAGG	0.637000												
KHDRBS2	202559	broad.mit.edu	37	6	62390958	62390958	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:62390958T>A	uc003peg.2	-	9	1207	c.960A>T	c.(958-960)GAA>GAT	p.E320D		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TGGCCCATTCTTCTGGTGCTG	0.448000												
MCHR2	84539	broad.mit.edu	37	6	100382309	100382309	+	Silent	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:100382309A>C	uc003pqh.1	-	5	987	c.672T>G	c.(670-672)ACT>ACG	p.T224T	MCHR2_uc003pqi.1_Silent_p.T224T	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	224	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		ACATCTCCCAAGTATAGCATA	0.299000												
QRSL1	55278	broad.mit.edu	37	6	107088263	107088263	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:107088263G>A	uc003prm.2	+	2	180	c.64G>A	c.(64-66)GAG>AAG	p.E22K	QRSL1_uc003prl.2_Missense_Mutation_p.E22K	NM_018292	NP_060762	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase	22					translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		TACACCAACAGAGCTCTGTCA	0.373000												
LAMA4	3910	broad.mit.edu	37	6	112512889	112512889	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:112512889G>A	uc003pvu.2	-	6	976	c.667C>T	c.(667-669)CGT>TGT	p.R223C	LAMA4_uc003pvv.2_Missense_Mutation_p.R223C|LAMA4_uc003pvt.2_Missense_Mutation_p.R223C	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	223	Laminin EGF-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GGAGCGCAACGTTCACACTTG	0.502000												
TAAR5	9038	broad.mit.edu	37	6	132909837	132909837	+	Missense_Mutation	SNP	C	C	T	rs145127866	byFrequency	TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:132909837C>T	uc003qdk.2	-	1	1041	c.989G>A	c.(988-990)CGC>CAC	p.R330H		NM_003967	NP_003958	O14804	TAAR5_HUMAN	trace amine associated receptor 5	330	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		ATCAACAGTGCGTGTCTGCGG	0.493000												
TBPL1	9519	broad.mit.edu	37	6	134305750	134305750	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:134305750G>A	uc010kgg.2	+	6	982	c.422G>A	c.(421-423)CGG>CAG	p.R141Q	TBPL1_uc003qel.2_Missense_Mutation_p.R141Q	NM_004865	NP_004856	P62380	TBPL1_HUMAN	TBP-like 1	141					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	cytoplasm	DNA binding|protein binding|transcription coactivator activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00591)|OV - Ovarian serous cystadenocarcinoma(155;0.00848)		GTGTGCTATCGGATAAAATCT	0.313000												
HIVEP2	3097	broad.mit.edu	37	6	143093770	143093770	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:143093770G>A	uc003qjd.2	-	5	2849	c.2106C>T	c.(2104-2106)AGC>AGT	p.S702S		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	702					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CATCCCCTACGCTCTTCTCTT	0.512000												
STX11	8676	broad.mit.edu	37	6	144507996	144507996	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:144507996C>T	uc003qks.3	+	2	424	c.232C>T	c.(232-234)CGC>TGC	p.R78C		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	78					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GTCCATGCGGCGCCTCAGCAG	0.627000									Familial_Hemophagocytic_Lymphohistiocytosis			
UTRN	7402	broad.mit.edu	37	6	144801088	144801088	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:144801088A>C	uc003qkt.2	+	25	3569	c.3477A>C	c.(3475-3477)GAA>GAC	p.E1159D	UTRN_uc010khq.1_Missense_Mutation_p.E1159D	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1159	Spectrin 8.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AGTCACCAGAAGAGCTTGAGA	0.517000												
PACRG	135138	broad.mit.edu	37	6	163735984	163735984	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:163735984G>A	uc003qua.2	+	7	1080	c.856G>A	c.(856-858)GTG>ATG	p.V286M	PACRG_uc003qub.2_Missense_Mutation_p.V247M|PACRG_uc003quc.2_Missense_Mutation_p.V247M|LOC285796_uc011egh.1_Intron	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	286											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		CATTAAGTACGTGGTCCCAAC	0.507000												
DLL1	28514	broad.mit.edu	37	6	170592364	170592364	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:170592364T>G	uc003qxm.2	-	9	2473	c.2003A>C	c.(2002-2004)CAG>CCG	p.Q668P		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	668	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TGAGGAGCCCTGGGGCTGGCA	0.677000												
DLL1	28514	broad.mit.edu	37	6	170594140	170594140	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr6:170594140G>A	uc003qxm.2	-	8	1586	c.1116C>T	c.(1114-1116)GAC>GAT	p.D372D		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	372	Extracellular (Potential).|EGF-like 5.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		AGCAAGGGCCGTCCGCACAGG	0.582000												
SDK1	221935	broad.mit.edu	37	7	4218127	4218127	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:4218127G>T	uc003smx.2	+	35	5146	c.5007G>T	c.(5005-5007)AAG>AAT	p.K1669N	SDK1_uc010kso.2_Missense_Mutation_p.K925N|SDK1_uc003smy.2_Missense_Mutation_p.K156N	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1669	Fibronectin type-III 10.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ATTTAAAGAAGTACCGGCGCT	0.522000												
SDK1	221935	broad.mit.edu	37	7	4247869	4247869	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:4247869G>A	uc003smx.2	+	37	5492	c.5353G>A	c.(5353-5355)GGA>AGA	p.G1785R	SDK1_uc010kso.2_Missense_Mutation_p.G1041R|SDK1_uc003smy.2_Missense_Mutation_p.G272R	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1785	Fibronectin type-III 11.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAACGCCGCCGGAGATGGACC	0.602000												
TXNDC3	51314	broad.mit.edu	37	7	37907454	37907454	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:37907454G>A	uc003tfn.2	+	11	1144	c.772G>A	c.(772-774)GTC>ATC	p.V258I		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	258					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						TCAACCTGAGGTCGAAGCCCA	0.438000									Kartagener_syndrome			
URGCP	55665	broad.mit.edu	37	7	43917267	43917267	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:43917267T>C	uc003tiw.2	-	6	1852	c.1795A>G	c.(1795-1797)ACC>GCC	p.T599A	URGCP_uc003tiu.2_Missense_Mutation_p.T556A|URGCP_uc003tiv.2_Missense_Mutation_p.T524A|URGCP_uc003tix.2_Missense_Mutation_p.T590A|URGCP_uc003tiy.2_Missense_Mutation_p.T556A|URGCP_uc003tiz.2_Missense_Mutation_p.T556A|URGCP_uc011kbj.1_Missense_Mutation_p.T556A	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	599					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						ACGTCTGTGGTGCCCCCATGC	0.632000												
VSTM2A	222008	broad.mit.edu	37	7	54612434	54612434	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:54612434C>T	uc010kzf.2	+	2	604	c.199C>T	c.(199-201)CGG>TGG	p.R67W	VSTM2A_uc010kze.2_Missense_Mutation_p.R67W|VSTM2A_uc003tqc.3_Missense_Mutation_p.R67W	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2	67	Ig-like V-type.					extracellular region					0			STAD - Stomach adenocarcinoma(5;0.0525)			GTGGTTCCTGCGGGGGCCGGA	0.721000												
TYW1	55253	broad.mit.edu	37	7	66479483	66479483	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:66479483C>A	uc003tvn.2	+	5	654	c.505C>A	c.(505-507)CTG>ATG	p.L169M	TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	169	Flavodoxin-like.				tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				CAAAACTTACCTGAAGGGTAT	0.428000												
PCLO	27445	broad.mit.edu	37	7	82545713	82545713	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:82545713T>G	uc003uhx.2	-	7	11878	c.11589A>C	c.(11587-11589)GAA>GAC	p.E3863D	PCLO_uc003uhv.2_Missense_Mutation_p.E3863D|PCLO_uc010lec.2_Missense_Mutation_p.E828D	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3794	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTGGCTGAATTCAGTTTGGG	0.458000												
SEMA3A	10371	broad.mit.edu	37	7	83590815	83590815	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:83590815G>A	uc003uhz.2	-	17	2503	c.2188C>T	c.(2188-2190)CGA>TGA	p.R730*		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	730	Arg/Lys-rich (basic).				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						CGTTGTTTTCGGTCCCTTTTC	0.468000												
COL1A2	1278	broad.mit.edu	37	7	94038121	94038121	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:94038121G>A	uc003ung.1	+	16	1249	c.778G>A	c.(778-780)GCC>ACC	p.A260T	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	260					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTTCCCAGGTGCCCCTGGCCC	0.433000										HNSCC(75;0.22)		
RELN	5649	broad.mit.edu	37	7	103143594	103143594	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:103143594C>T	uc003vca.2	-	52	8518	c.8358G>A	c.(8356-8358)TGG>TGA	p.W2786*	RELN_uc010liz.2_Nonsense_Mutation_p.W2786*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2786	BNR 13.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCAGATAATTCCAACTCACAC	0.413000												
PTPRZ1	5803	broad.mit.edu	37	7	121650904	121650904	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:121650904A>G	uc003vjy.2	+	12	2199	c.1804A>G	c.(1804-1806)AAC>GAC	p.N602D	PTPRZ1_uc003vjz.2_Missense_Mutation_p.N602D|PTPRZ1_uc011knt.1_Missense_Mutation_p.N52D	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	602	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CATCTCTGAGAACATATCCCA	0.423000												
GRM8	2918	broad.mit.edu	37	7	126086287	126086287	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:126086287T>G	uc003vlr.2	-	9	2881	c.2570A>C	c.(2569-2571)AAG>ACG	p.K857T	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.K857T|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	857	Cytoplasmic (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CACCACAGCCTTGAAGCTCCT	0.418000										HNSCC(24;0.065)		
GRM8	2918	broad.mit.edu	37	7	126086390	126086390	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:126086390T>G	uc003vlr.2	-	9	2778	c.2467A>C	c.(2467-2469)AGT>CGT	p.S823R	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.S823R|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	823	Helical; Name=7; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCACTTAAACTCATGGAGACA	0.368000										HNSCC(24;0.065)		
GCC1	79571	broad.mit.edu	37	7	127223170	127223170	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:127223170G>A	uc003vma.2	-	2	1644	c.1226C>T	c.(1225-1227)GCT>GTT	p.A409V		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	409	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						GGCTGCTAGAGCCAGTGTCTT	0.542000												
DGKI	9162	broad.mit.edu	37	7	137096916	137096916	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:137096916C>T	uc003vtt.2	-	30	2824	c.2823G>A	c.(2821-2823)AAG>AAA	p.K941K	DGKI_uc003vtu.2_Silent_p.K610K	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	941					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GATATCTTACCTTCATAAGAT	0.343000												
OR9A4	130075	broad.mit.edu	37	7	141619330	141619330	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:141619330G>A	uc003vwu.1	+	1	655	c.655G>A	c.(655-657)GCC>ACC	p.A219T		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					TGTCTCCAACGCCTACATCAT	0.448000												
LRRC61	65999	broad.mit.edu	37	7	150034324	150034324	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:150034324A>C	uc003wgv.2	+	3	1048	c.374A>C	c.(373-375)GAG>GCG	p.E125A	LRRC61_uc003wgx.2_Missense_Mutation_p.E125A|LRRC61_uc003wgw.2_Missense_Mutation_p.E125A|LRRC61_uc003wgz.3_Missense_Mutation_p.E125A	NM_023942	NP_076431	Q9BV99	LRC61_HUMAN	leucine rich repeat containing 61	125											0			OV - Ovarian serous cystadenocarcinoma(82;0.011)			CCGTGCCTGGAGTACCTGCGG	0.657000												
MLL3	58508	broad.mit.edu	37	7	151927304	151927304	+	Splice_Site	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:151927304C>T	uc003wla.2	-	17	3090	c.2871_splice	c.e17+1	p.Q957_splice	MLL3_uc003wkz.2_Splice_Site_p.Q18_splice	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3						intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CAAGTTCAAACCTGATTCAAA	0.343000			N		medulloblastoma							
NOM1	64434	broad.mit.edu	37	7	156762348	156762348	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr7:156762348C>G	uc003wmy.2	+	11	2549	c.2534C>G	c.(2533-2535)GCT>GGT	p.A845G		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	845					RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		AGAGAGAAAGCTGACCTTGCA	0.512000												
KCTD9	54793	broad.mit.edu	37	8	25301820	25301820	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr8:25301820C>G	uc003xeo.2	-	3	360	c.202G>C	c.(202-204)GAG>CAG	p.E68Q	PPP2R2A_uc003xek.2_Intron	NM_017634	NP_060104	Q7L273	KCTD9_HUMAN	potassium channel tetramerisation domain	68	KHA.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)		ATAAATGGCTCTCCTTCACAA	0.284000												
CYP7B1	9420	broad.mit.edu	37	8	65536986	65536986	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr8:65536986C>G	uc003xvj.2	-	2	437	c.233G>C	c.(232-234)GGT>GCT	p.G78A		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	78					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				GAAAGTGTCACCATGTTGCTT	0.368000												
FAM135B	51059	broad.mit.edu	37	8	139263121	139263121	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr8:139263121G>A	uc003yuy.2	-	6	676	c.505C>T	c.(505-507)CAT>TAT	p.H169Y	FAM135B_uc003yux.2_Missense_Mutation_p.H70Y|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	169										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGGGCAGCATGGACGGTCACC	0.582000										HNSCC(54;0.14)		
ADAMTSL1	92949	broad.mit.edu	37	9	18706804	18706804	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr9:18706804G>A	uc003zne.3	+	14	1761	c.1634G>A	c.(1633-1635)CGA>CAA	p.R545Q		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	545	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		ACCCAGGTGCGAATAGTCAGG	0.602000												
TRPM3	80036	broad.mit.edu	37	9	73442926	73442926	+	Silent	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr9:73442926C>T	uc004aid.2	-	6	1054	c.810G>A	c.(808-810)CGG>CGA	p.R270R	TRPM3_uc004ahu.2_Silent_p.R100R|TRPM3_uc004ahv.2_Silent_p.R100R|TRPM3_uc004ahw.2_Silent_p.R117R|TRPM3_uc004ahx.2_Silent_p.R117R|TRPM3_uc004ahy.2_Silent_p.R117R|TRPM3_uc004ahz.2_Silent_p.R117R|TRPM3_uc004aia.2_Silent_p.R117R|TRPM3_uc004aib.2_Silent_p.R117R|TRPM3_uc004aic.2_Silent_p.R270R|TRPM3_uc010mor.2_Silent_p.R270R|TRPM3_uc004aie.2_Silent_p.R117R|TRPM3_uc004aif.2_Silent_p.R117R|TRPM3_uc004aig.2_Silent_p.R117R|TRPM3_uc004aii.2_Silent_p.R272R	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	270	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TCTGGTATGGCCGGACAACCT	0.458000												
TRPM6	140803	broad.mit.edu	37	9	77377031	77377031	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr9:77377031A>C	uc004ajl.1	-	26	4794	c.4556T>G	c.(4555-4557)CTT>CGT	p.L1519R	TRPM6_uc004ajk.1_Missense_Mutation_p.L1514R|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.L475R	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1519	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTTTGGCTGAAGCCATGGTCC	0.498000												
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899268	112899268	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr9:112899268G>A	uc004bei.2	+	9	2332	c.2140G>A	c.(2140-2142)GAG>AAG	p.E714K	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.E482K|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.E482K|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.E292K|AKAP2_uc011lwi.1_Missense_Mutation_p.E340K|AKAP2_uc004bem.2_Missense_Mutation_p.E340K|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.E300K|AKAP2_uc011lwj.1_Missense_Mutation_p.E251K|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.E251K	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	251	Potential.						enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AAAAACCATCGAGGAGCAGCT	0.453000												
TNC	3371	broad.mit.edu	37	9	117791715	117791715	+	Silent	SNP	G	G	A	rs150281525		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr9:117791715G>A	uc004bjj.3	-	25	6455	c.6093C>T	c.(6091-6093)AAC>AAT	p.N2031N	TNC_uc010mvf.2_Silent_p.N1758N	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	2031	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TCTCGCGTCCGTTTTTGCGTC	0.383000												
PAPPA	5069	broad.mit.edu	37	9	118973933	118973933	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr9:118973933A>C	uc004bjn.2	+	4	2021	c.1640A>C	c.(1639-1641)AAC>ACC	p.N547T	PAPPA_uc011lxp.1_Intron|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	547	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						ATTGTCTTGAACCCATCTTTC	0.502000												
FRMPD4	9758	broad.mit.edu	37	X	12627882	12627882	+	Silent	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chrX:12627882G>A	uc004cuz.1	+	3	707	c.201G>A	c.(199-201)GAG>GAA	p.E67E	FRMPD4_uc011mij.1_Silent_p.E59E	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	67					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CTCGGTTAGAGAGCTGCCAAA	0.522000												
MED12	9968	broad.mit.edu	37	X	70347218	70347218	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chrX:70347218G>A	uc004dyy.2	+	21	3081	c.2882G>A	c.(2881-2883)CGG>CAG	p.R961Q	MED12_uc011mpq.1_Missense_Mutation_p.R961Q|MED12_uc004dyz.2_Missense_Mutation_p.R961Q|MED12_uc004dza.2_Missense_Mutation_p.R808Q|MED12_uc010nla.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	961			R -> W (in OKS).		androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GGGATGAACCGGTCCGATGGC	0.522000												
KLHL4	56062	broad.mit.edu	37	X	86887303	86887303	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chrX:86887303T>C	uc004efb.2	+	7	1600	c.1418T>C	c.(1417-1419)GTT>GCT	p.V473A	KLHL4_uc004efa.2_Missense_Mutation_p.V473A	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	473	Kelch 1.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGAGTCGCAGTTATTGATAAT	0.403000												
CPXCR1	53336	broad.mit.edu	37	X	88008710	88008710	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chrX:88008710A>T	uc004efd.3	+	3	554	c.295A>T	c.(295-297)AAA>TAA	p.K99*	CPXCR1_uc004efc.3_Nonsense_Mutation_p.K99*	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	99						intracellular	zinc ion binding			ovary(3)	3						CATTCCCAGAAAATTGGTCTC	0.408000												
DCAF12L2	340578	broad.mit.edu	37	X	125298766	125298766	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chrX:125298766T>G	uc004euk.1	-	1	1169	c.1142A>C	c.(1141-1143)AAG>ACG	p.K381T		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	381	WD 4.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CTCCAGGAACTTCTGGGCGCG	0.632000												
GABRE	2564	broad.mit.edu	37	X	151123878	151123878	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chrX:151123878T>G	uc004ffi.2	-	8	1153	c.1099A>C	c.(1099-1101)AAC>CAC	p.N367H	GABRE_uc011myd.1_RNA	NM_004961	NP_004952	P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor,	367	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGTCTGGTTGTAGATCAGG	0.493000												
PNMA3	29944	broad.mit.edu	37	X	152226465	152226465	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chrX:152226465A>T	uc004fhc.2	+	2	1389	c.1053A>T	c.(1051-1053)GAA>GAT	p.E351D	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	351					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGGCTGGAAGTAGCCCCAA	0.428000												
SRY	6736	broad.mit.edu	37	Y	2655179	2655179	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chrY:2655179C>T	uc004fqg.1	-	1	614	c.466G>A	c.(466-468)GAA>AAA	p.E156K		NM_003140	NP_003131	Q05066	SRY_HUMAN	sex determining region Y	156					cell differentiation|male sex determination|positive regulation of transcription, DNA-dependent|sex differentiation	cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0						AGTTGCACTTCGCTGCAGAGT	0.527000									Swyer_syndrome			
KIF11	3832	broad.mit.edu	37	10	94409609	94409610	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr10:94409609_94409610delAA	uc001kic.2	+	20	3096_3097	c.2788_2789delAA	c.(2788-2790)AAAfs	p.K930fs	KIF11_uc010qnq.1_RNA	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	930					blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						ACCACAGAGGAAAAGTTATTTA	0.337												
C8orf80	389643	broad.mit.edu	37	8	27905066	27905066	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr8:27905066delG	uc003xgm.3	-	11	1413	c.1270delC	c.(1270-1272)CAGfs	p.Q424fs		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	424						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		CAGTACTCCTGGGCGCTGACT	0.453												
ARID1A	8289	broad.mit.edu	37	1	27105931	27105932	+	Frame_Shift_Ins	INS	-	-	G	rs140055856		TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr1:27105930_27105931T>TG	uc001bmv.1	+	19	5914_5915	c.5541_5542T>TG	c.(5539-5544)ggtgggfs	p.G1847fs	ARID1A_uc001bmu.1_Frame_Shift_Ins_p.G1630fs|ARID1A_uc001bmx.1_Frame_Shift_Ins_p.G693fs|ARID1A_uc009vsm.1_Frame_Shift_Ins_p.G175fs|ARID1A_uc009vsn.1_Frame_Shift_Ins_p.G89fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 1, mRNA.	1847					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	SWI/SNF complex|nBAF complex|npBAF complex	DNA binding|protein binding	p.G1848fs*6(6)|p.G1847fs*36(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGCGGATTGGTGGGGGGGACAC	0.579			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""							
RHOJ	57381	broad.mit.edu	37	14	63757715	63757716	+	Frame_Shift_Ins	INS	-	-	G			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr14:63757714_63757715A>AG	uc001xgb.2	+	4	1103_1104	c.617_618A>AG	c.(616-618)gagfs	p.E206fs		NM_020663	NP_065714	Q9H4E5	RHOJ_HUMAN	Homo sapiens ras homolog gene family, member J (RHOJ), mRNA.	206					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		CGCTGTTCTGAGGGTCACAGCT	0.500												
C15orf2	23742	broad.mit.edu	37	15	24922934	24922934	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr15:24922933_24922933GA>G	uc001ywo.3	+	0	2393	c.1919_1919GA>G	c.(1918-1920)ggafs	p.G640fs		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	Homo sapiens chromosome 15 open reading frame 2 (C15orf2), mRNA.	640					cell differentiation|multicellular organismal development|spermatogenesis					NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(1)|large_intestine(28)|lung(77)|ovary(5)|pancreas(1)|skin(8)	140		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CAACTCTTTGGAAAAGAAGCC	0.507												
SLC7A6OS	84138	broad.mit.edu	37	16	68335220	68335222	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-D7-A4YU-01A-21D-A25D-08	TCGA-D7-A4YU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	63220bf2-a703-4487-b97c-3be4140b4f0d	63ddf1ce-74da-436e-ab08-d445c7b1860a	g.chr16:68335219_68335221CCTT>C	uc002evw.2	-	4	926_928	c.887_889AAGG>G	c.(886-891)aaggag>aGag	p.296_297KE>R	SLC7A6_uc002evv.2_Non-coding_Transcript|SLC7A6_uc002evt.2_3'UTR|SLC7A6_uc002evu.2_3'UTR|SLC7A6_uc010cfc.1_Non-coding_Transcript	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	Homo sapiens solute carrier family 7, member 6 opposite strand (SLC7A6OS), mRNA.	296					protein transport	cytoplasm|nucleus				breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	10		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		TAGCCGAACTCCTTCTGCACATC	0.547