Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
IFI44L	10964	broad.mit.edu	37	1	79102793	79102793	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr1:79102793G>A	uc010oro.1	+	6	1132	c.953G>A	c.(952-954)TGT>TAT	p.C318Y	IFI44L_uc010orp.1_Missense_Mutation_p.C55Y|IFI44L_uc010orq.1_Missense_Mutation_p.C55Y	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	318						cytoplasm					0						AGGATTCACTGTGTGGCTTAT	0.363000												
BCL10	8915	broad.mit.edu	37	1	85736384	85736384	+	Missense_Mutation	SNP	C	C	T	rs147850504		TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr1:85736384C>T	uc001dkz.2	-	3	968	c.263G>A	c.(262-264)CGA>CAA	p.R88Q		NM_003921	NP_003912	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	88	CARD.				apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			lung(2)	2				all cancers(265;0.0114)|Epithelial(280;0.0311)		TGTTTTTTCTCGCCGAATAGA	0.348000			T	IGH@	MALT 							
CELSR2	1952	broad.mit.edu	37	1	109794776	109794776	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr1:109794776G>A	uc001dxa.3	+	1	2136	c.2075G>A	c.(2074-2076)CGG>CAG	p.R692Q		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	692	Cadherin 5.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GATGGCACTCGGCAGGACACG	0.557000												
HIPK1	204851	broad.mit.edu	37	1	114483281	114483281	+	Silent	SNP	G	G	T	rs145171448	byFrequency	TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr1:114483281G>T	uc001eem.2	+	2	437	c.276G>T	c.(274-276)TCG>TCT	p.S92S	HIPK1_uc001eel.2_Silent_p.S92S|HIPK1_uc001een.2_Silent_p.S92S	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGATAGCTCGGGCAGTGCTG	0.502000												
HMCN1	83872	broad.mit.edu	37	1	185988786	185988786	+	Missense_Mutation	SNP	A	A	C	rs147131235		TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr1:185988786A>C	uc001grq.1	+	35	5813	c.5584A>C	c.(5584-5586)AAA>CAA	p.K1862Q		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1862	Ig-like C2-type 16.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TACATGGTTAAAAGATGACCA	0.423000												
KCNT2	343450	broad.mit.edu	37	1	196398803	196398803	+	Silent	SNP	A	A	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr1:196398803A>T	uc001gtd.1	-	9	783	c.723T>A	c.(721-723)TCT>TCA	p.S241S	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.S241S|KCNT2_uc001gtf.1_Silent_p.S241S|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Silent_p.S241S|KCNT2_uc009wyv.1_Silent_p.S216S	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	241						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						AGCCCACAGTAGAAAACGTCA	0.413000												
IGFN1	91156	broad.mit.edu	37	1	201195249	201195249	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr1:201195249G>A	uc001gwc.2	+	11	3036	c.2264G>A	c.(2263-2265)CGC>CAC	p.R755H	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CCCCGGCAGCGCGGTAAGCAG	0.662000												
C1orf58	148362	broad.mit.edu	37	1	222892355	222892355	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr1:222892355T>C	uc001hnq.1	+	3	585	c.190T>C	c.(190-192)TAT>CAT	p.Y64H	C1orf58_uc010put.1_Missense_Mutation_p.Y64H|C1orf58_uc010puu.1_Missense_Mutation_p.Y64H|C1orf58_uc010puv.1_Missense_Mutation_p.Y64H	NM_144695	NP_653296	Q5VW32	BROX_HUMAN	Bro1-domain-containing protein	64						membrane					0				GBM - Glioblastoma multiforme(131;0.0667)		AGCAGATTCATATTTCTCACT	0.318000												
PTCHD3	374308	broad.mit.edu	37	10	27702994	27702994	+	Silent	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr10:27702994C>T	uc001itu.2	-	1	304	c.186G>A	c.(184-186)TCG>TCA	p.S62S		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	62					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CATCCTGCTCCGACGCCAGGG	0.697000												
MUC6	4588	broad.mit.edu	37	11	1031906	1031906	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr11:1031906C>T	uc001lsw.2	-	3	314	c.263G>A	c.(262-264)CGA>CAA	p.R88Q		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	88	VWFD 1.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTCTGGGCCTCGCCGCAGCTG	0.622000												
FCHSD2	9873	broad.mit.edu	37	11	72695249	72695249	+	Silent	SNP	G	G	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr11:72695249G>T	uc009ytl.2	-	8	810	c.589C>A	c.(589-591)CGA>AGA	p.R197R	FCHSD2_uc010rrg.1_Silent_p.R37R|FCHSD2_uc001oth.3_Silent_p.R141R|FCHSD2_uc001oti.2_Silent_p.R156R	NM_014824	NP_055639	O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	197							protein binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			CACTCAGATCGCCGGGCTTTT	0.378000												
FAT3	120114	broad.mit.edu	37	11	92616530	92616530	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr11:92616530G>A	uc001pdj.3	+	23	12925	c.12908G>A	c.(12907-12909)CGG>CAG	p.R4303Q	FAT3_uc001pdi.3_Missense_Mutation_p.R743Q	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4303	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACTCCATCCGGAAGAATGGC	0.672000										TCGA Ovarian(4;0.039)		
ENDOD1	23052	broad.mit.edu	37	11	94861549	94861549	+	Silent	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr11:94861549C>T	uc001pfh.2	+	2	384	c.309C>T	c.(307-309)GAC>GAT	p.D103D		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	103						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				AGATCGATGACCCCAACAGCA	0.507000												
ATN1	1822	broad.mit.edu	37	12	7045235	7045235	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr12:7045235G>A	uc001qrw.1	+	5	1042	c.805G>A	c.(805-807)GGT>AGT	p.G269S	ATN1_uc001qrx.1_Missense_Mutation_p.G269S|ATN1_uc001qry.1_Missense_Mutation_p.G268S	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	269					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TGGGGCTAGTGGTGCTCCCCC	0.622000												
DPF3	8110	broad.mit.edu	37	14	73190342	73190342	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr14:73190342C>T	uc001xnc.2	-	5	537	c.524G>A	c.(523-525)CGG>CAG	p.R175Q	DPF3_uc001xnd.1_RNA|DPF3_uc001xnf.2_RNA|DPF3_uc010ari.1_Missense_Mutation_p.R175Q|DPF3_uc010ttq.1_Missense_Mutation_p.R185Q	NM_012074	NP_036206	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	175					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CCAACTTACCCGTCCTCTAGT	0.478000												
C14orf102	55051	broad.mit.edu	37	14	90767687	90767687	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr14:90767687G>A	uc001xyi.1	-	7	1472	c.1441C>T	c.(1441-1443)CGG>TGG	p.R481W	C14orf102_uc010atp.1_5'UTR|C14orf102_uc001xyj.1_Missense_Mutation_p.R250W	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	481							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		CCAGCCTGCCGCAGAAAGTGG	0.517000												
PML	5371	broad.mit.edu	37	15	74325745	74325745	+	Silent	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr15:74325745C>T	uc002awv.2	+	6	1787	c.1647C>T	c.(1645-1647)GCC>GCT	p.A549A	PML_uc002awm.2_Silent_p.A549A|PML_uc002awl.2_Intron|PML_uc002awj.1_Silent_p.A501A|PML_uc002awk.2_Silent_p.A549A|PML_uc002awn.2_Silent_p.A549A|PML_uc002awo.2_Silent_p.A501A|PML_uc002awp.2_Intron|PML_uc002awq.2_Silent_p.A549A|PML_uc002awr.2_Silent_p.A549A|PML_uc002aws.2_Silent_p.A501A|PML_uc002awt.2_Intron|PML_uc002awu.2_Silent_p.A501A|PML_uc010ule.1_Silent_p.A110A|PML_uc002awx.2_Silent_p.A259A|PML_uc002awy.2_5'UTR	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	549					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						CCAGTGGCGCCGGGGAGGCAG	0.662000			T	RARA|PAX5	APL|ALL							
C16orf71	146562	broad.mit.edu	37	16	4797531	4797531	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr16:4797531G>T	uc002cxn.2	+	9	1930	c.1468G>T	c.(1468-1470)GCT>TCT	p.A490S		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	490										central_nervous_system(1)	1						GAGCGCCCAGGCTCGACTCCC	0.657000												
NLRC5	84166	broad.mit.edu	37	16	57059473	57059473	+	Silent	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr16:57059473C>T	uc002ekk.1	+	6	843	c.618C>T	c.(616-618)GAC>GAT	p.D206D	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Silent_p.D11D|NLRC5_uc002ekl.2_Silent_p.D11D|NLRC5_uc002ekm.2_Silent_p.D11D|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	206					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				ATGGTGCTGACGTGAGCATCT	0.612000												
GPR114	221188	broad.mit.edu	37	16	57609350	57609350	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr16:57609350G>T	uc002elx.3	+	12	1572	c.1487G>T	c.(1486-1488)GGT>GTT	p.G496V	GPR114_uc010vhr.1_3'UTR|GPR114_uc002ely.2_Missense_Mutation_p.G496V	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	496	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						TCTCTTGCAGGTTTCTTCCTT	0.617000												
GEMIN4	50628	broad.mit.edu	37	17	649304	649304	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr17:649304A>C	uc002frs.1	-	2	2098	c.1979T>G	c.(1978-1980)TTG>TGG	p.L660W		NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	660					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		ATCTAACCTCAAGAAAGGCAG	0.532000												
YWHAE	7531	broad.mit.edu	37	17	1264542	1264542	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr17:1264542C>T	uc002fsj.2	-	4	574	c.422G>A	c.(421-423)AGG>AAG	p.R141K	YWHAE_uc002fsk.2_Missense_Mutation_p.R119K|YWHAE_uc010vqh.1_RNA|YWHAE_uc010vqi.1_Intron	NM_006761	NP_006752	P62258	1433E_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	141					apoptosis|G2/M transition of mitotic cell cycle|induction of apoptosis by extracellular signals|interspecies interaction between organisms|intracellular signal transduction|nerve growth factor receptor signaling pathway	cytosol|melanosome	histone deacetylase binding|phosphoserine binding			lung(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(18;0.203)	UCEC - Uterine corpus endometrioid carcinoma (25;0.0887)		AGCCTCCTTCCTGTCGTTTCC	0.413000												
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	G	T	rs121913343		TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr17:7577121G>T	uc002gim.2	-	8	1011	c.817C>A	c.(817-819)CGT>AGT	p.R273S	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141S|TP53_uc010cng.1_Missense_Mutation_p.R141S|TP53_uc002gii.1_Missense_Mutation_p.R141S|TP53_uc010cnh.1_Missense_Mutation_p.R273S|TP53_uc010cni.1_Missense_Mutation_p.R273S|TP53_uc002gij.2_Missense_Mutation_p.R273S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542000	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
SLC13A2	9058	broad.mit.edu	37	17	26818792	26818792	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr17:26818792T>A	uc002hbh.2	+	6	867	c.800T>A	c.(799-801)TTC>TAC	p.F267Y	SLC13A2_uc010wal.1_Missense_Mutation_p.F224Y|SLC13A2_uc010wam.1_Missense_Mutation_p.F223Y|SLC13A2_uc010wan.1_Missense_Mutation_p.F316Y|SLC13A2_uc010wao.1_Missense_Mutation_p.F224Y|SLC13A2_uc002hbi.2_Missense_Mutation_p.F196Y	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	267						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GCCTCCTGGTTCAGCTTCGCC	0.582000												
RALBP1	10928	broad.mit.edu	37	18	9535916	9535916	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr18:9535916G>A	uc002kob.2	+	10	2172	c.1949G>A	c.(1948-1950)AGG>AAG	p.R650K	RALBP1_uc002koc.2_Missense_Mutation_p.R650K	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	650					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						AGCAGGGATAGGAAGGAGACG	0.632000												
ST8SIA5	29906	broad.mit.edu	37	18	44260212	44260212	+	Silent	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr18:44260212C>T	uc002lcj.1	-	7	1492	c.924G>A	c.(922-924)GCG>GCA	p.A308A	ST8SIA5_uc002lci.1_Silent_p.A155A|ST8SIA5_uc010xcy.1_Silent_p.A344A|ST8SIA5_uc010xcz.1_Silent_p.A277A	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	308	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GCTCCAGCGCCGCAGTGACCA	0.607000												
SYDE1	85360	broad.mit.edu	37	19	15224376	15224376	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr19:15224376C>T	uc002nah.1	+	8	1841	c.1810C>T	c.(1810-1812)CGC>TGC	p.R604C	SYDE1_uc002nai.1_Missense_Mutation_p.R537C|SYDE1_uc002naj.1_Missense_Mutation_p.R261C	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	604	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2						TTCAGATCCCCGCCTGCCCCG	0.607000												
BCKDHA	593	broad.mit.edu	37	19	41920017	41920017	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr19:41920017G>A	uc002oqq.2	+	4	468	c.439G>A	c.(439-441)GCC>ACC	p.A147T	CYP2F1_uc010xvw.1_Intron|BCKDHA_uc002oqm.3_Missense_Mutation_p.A181T|BCKDHA_uc002oqp.1_Missense_Mutation_p.A39T|BCKDHA_uc002oqr.2_Missense_Mutation_p.A147T|BCKDHA_uc010xvz.1_Missense_Mutation_p.A125T	NM_000709	NP_000700	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha	147					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding				0						GAGTGCCGCCGCCCTGGACAA	0.607000												
NLRP2	55655	broad.mit.edu	37	19	55494535	55494535	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr19:55494535G>A	uc002qij.2	+	6	1555	c.1469G>A	c.(1468-1470)CGC>CAC	p.R490H	NLRP2_uc010yfp.1_Missense_Mutation_p.R467H|NLRP2_uc010esn.2_Missense_Mutation_p.R466H|NLRP2_uc010eso.2_Missense_Mutation_p.R487H|NLRP2_uc010esp.2_Missense_Mutation_p.R468H	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	490	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GACATCCTCCGCCAGGACAGA	0.602000												
ADCY3	109	broad.mit.edu	37	2	25044392	25044392	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr2:25044392G>A	uc002rfs.3	-	19	3320	c.3121C>T	c.(3121-3123)CGC>TGC	p.R1041C	ADCY3_uc002rfr.3_Missense_Mutation_p.R628C|ADCY3_uc010ykm.1_Missense_Mutation_p.R1042C	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	1041	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TCACCTATGCGCAGCATGAAG	0.617000												
CAPN13	92291	broad.mit.edu	37	2	30966280	30966280	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr2:30966280G>A	uc002rnn.2	-	12	1590	c.1414C>T	c.(1414-1416)CGA>TGA	p.R472*	CAPN13_uc002rnm.2_RNA|CAPN13_uc002rno.2_Nonsense_Mutation_p.R26*	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	472					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AGGAAGATTCGGAGCAAGAAC	0.408000												
UGGT1	56886	broad.mit.edu	37	2	128937376	128937376	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr2:128937376G>A	uc002tps.2	+	35	4010	c.3832G>A	c.(3832-3834)GTG>ATG	p.V1278M	UGGT1_uc002tpr.2_Missense_Mutation_p.V1254M	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	1278	Glucosyltransferase (By similarity).				'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						GATGCTATCCGTGCTGAAGAA	0.373000												
CENPB	1059	broad.mit.edu	37	20	3766016	3766016	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr20:3766016C>G	uc002wjk.2	-	1	1322	c.1115G>C	c.(1114-1116)TGG>TCG	p.W372S	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	372					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						CACTGCCTGCCAGGCGGCAGC	0.627000												
MYLK2	85366	broad.mit.edu	37	20	30414609	30414609	+	Silent	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr20:30414609C>T	uc002wwq.2	+	8	1194	c.1092C>T	c.(1090-1092)GGC>GGT	p.G364G	MYLK2_uc002wws.2_5'UTR	NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	364	Protein kinase.				cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GCATCGAGGGCGGAGAGCTCT	0.592000												
PREX1	57580	broad.mit.edu	37	20	47324856	47324856	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr20:47324856C>T	uc002xtw.1	-	6	748	c.725G>A	c.(724-726)CGG>CAG	p.R242Q		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	242					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CTCCATCTGCCGCTTGGTCTC	0.642000												
B4GALT5	9334	broad.mit.edu	37	20	48263510	48263510	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr20:48263510G>A	uc002xuu.3	-	3	550	c.356C>T	c.(355-357)CCT>CTT	p.P119L		NM_004776	NP_004767	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	119	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			ACTCATGGAAGGGAGTCTTTC	0.463000												
UFD1L	7353	broad.mit.edu	37	22	19444143	19444143	+	Silent	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr22:19444143G>A	uc002zpm.2	-	9	775	c.645C>T	c.(643-645)GAC>GAT	p.D215D	UFD1L_uc002zpo.2_Silent_p.D215D|UFD1L_uc011agy.1_Silent_p.D215D|UFD1L_uc002zpp.2_Silent_p.D168D	NM_005659	NP_005650	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1-like isoform A	215					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity				0	Colorectal(54;0.0993)					AGCCACTGTGGTCGGCTTCAC	0.567000												
SCN10A	6336	broad.mit.edu	37	3	38739948	38739948	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr3:38739948C>T	uc003ciq.2	-	27	4763	c.4763G>A	c.(4762-4764)CGA>CAA	p.R1588Q		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1588	IV.|Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTTGGCCGCTCGGATCAGTCT	0.517000												
CELSR3	1951	broad.mit.edu	37	3	48698891	48698891	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr3:48698891G>A	uc003cul.2	-	1	1458	c.1177C>T	c.(1177-1179)CGC>TGC	p.R393C	CELSR3_uc003cuf.1_Missense_Mutation_p.R463C	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	393	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ATGCTCTCGCGGTCCAGAGCT	0.672000												
SLC4A4	8671	broad.mit.edu	37	4	72313451	72313451	+	Splice_Site	SNP	G	G	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr4:72313451G>T	uc003hfy.2	+	9	1170	c.1053_splice	c.e9+1	p.E351_splice	SLC4A4_uc010iic.2_Splice_Site_p.E351_splice|SLC4A4_uc010iib.2_Splice_Site_p.E351_splice|SLC4A4_uc003hfz.2_Splice_Site_p.E351_splice|SLC4A4_uc003hgc.3_Splice_Site_p.E307_splice|SLC4A4_uc010iid.2_Splice_Site|SLC4A4_uc003hga.2_Splice_Site_p.E229_splice|SLC4A4_uc003hgb.3_Splice_Site_p.E307_splice	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate							basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GTCTGATGAGGTAGGAAATCA	0.418000												
LEF1	51176	broad.mit.edu	37	4	109010376	109010376	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr4:109010376A>G	uc003hyt.1	-	4	1107	c.452T>C	c.(451-453)GTC>GCC	p.V151A	LEF1_uc011cfj.1_Missense_Mutation_p.V36A|LEF1_uc011cfk.1_Missense_Mutation_p.V83A|LEF1_uc003hyu.1_Missense_Mutation_p.V151A|LEF1_uc003hyv.1_Missense_Mutation_p.V151A|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	151	Pro-rich.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GAGAGGATGGACCGCATGGGA	0.498000												
ODZ3	55714	broad.mit.edu	37	4	183675916	183675916	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr4:183675916G>A	uc003ivd.1	+	21	4433	c.4396G>A	c.(4396-4398)GCC>ACC	p.A1466T	ODZ3_uc003ive.1_Missense_Mutation_p.A879T	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1466	Extracellular (Potential).|NHL 5.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		AGATGGCTACGCCAAGGATGC	0.507000												
ADCY2	108	broad.mit.edu	37	5	7766854	7766854	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr5:7766854A>G	uc003jdz.1	+	17	2216	c.2149A>G	c.(2149-2151)ACA>GCA	p.T717A	ADCY2_uc011cmo.1_Missense_Mutation_p.T537A	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	717					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CACAACAAACACAAGCTTTTC	0.393000												
FBXO4	26272	broad.mit.edu	37	5	41934278	41934278	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr5:41934278A>C	uc003jmq.2	+	5	822	c.766A>C	c.(766-768)AAC>CAC	p.N256H	FBXO4_uc003jmp.2_Missense_Mutation_p.N256H|FBXO4_uc003jmr.2_Missense_Mutation_p.N256H	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	256					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				AAGTGCAGTTAACAAGATGTT	0.388000												
PJA2	9867	broad.mit.edu	37	5	108698688	108698688	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr5:108698688C>A	uc003kos.3	-	6	1725	c.1505G>T	c.(1504-1506)TGG>TTG	p.W502L		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	502					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		GTACTGTAACCAAGGAATTTC	0.358000												
FAT2	2196	broad.mit.edu	37	5	150921854	150921854	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr5:150921854T>A	uc003lue.3	-	9	8847	c.8834A>T	c.(8833-8835)TAC>TTC	p.Y2945F	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2945	Extracellular (Potential).|Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCTGTGATGTAGCAGGTGAC	0.453000												
EHMT2	10919	broad.mit.edu	37	6	31848468	31848468	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr6:31848468C>T	uc003nxz.1	-	27	3444	c.3434G>A	c.(3433-3435)CGG>CAG	p.R1145Q	EHMT2_uc003nxv.1_Missense_Mutation_p.R184Q|EHMT2_uc003nxw.1_Missense_Mutation_p.R184Q|EHMT2_uc003nxx.1_Missense_Mutation_p.R343Q|EHMT2_uc003nxy.1_Missense_Mutation_p.R943Q|EHMT2_uc011don.1_Missense_Mutation_p.R1168Q|EHMT2_uc003nya.1_Missense_Mutation_p.R1111Q|SLC44A4_uc010jti.2_5'Flank|SLC44A4_uc011dom.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1145	SET.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						CTCCCCAGTCCGGATGTCTCG	0.592000												
ZNF76	7629	broad.mit.edu	37	6	35260365	35260365	+	Silent	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr6:35260365C>T	uc003oki.1	+	10	1171	c.966C>T	c.(964-966)TGC>TGT	p.C322C	ZNF76_uc011dsz.1_Silent_p.C322C|ZNF76_uc003okj.1_Silent_p.C322C	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	322	C2H2-type 6.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCCAGGCTGCGGGAAACGCT	0.463000												
GUCA1A	2978	broad.mit.edu	37	6	42141400	42141400	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr6:42141400G>A	uc003orx.2	+	3	694	c.49G>A	c.(49-51)GAG>AAG	p.E17K	GUCA1A_uc011duo.1_RNA|GUCA1A_uc010jxt.2_Missense_Mutation_p.E17K	NM_000409	NP_000400	P43080	GUC1A_HUMAN	guanylate cyclase activator 1A (retina)	17	EF-hand 1.				signal transduction|visual perception	membrane	calcium ion binding|calcium sensitive guanylate cyclase activator activity				0	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;5.54e-05)|Epithelial(12;0.000167)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GAGCAGCACCGAGTGCCACCA	0.587000												
CDK13	8621	broad.mit.edu	37	7	40134360	40134360	+	Silent	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr7:40134360C>T	uc003thh.3	+	14	4602	c.4320C>T	c.(4318-4320)AGC>AGT	p.S1440S	CDK13_uc003thi.3_Silent_p.S1380S|CDK13_uc003thj.2_Silent_p.S491S|CDK13_uc003thk.2_Silent_p.S373S	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1440					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TGGCAAACAGCAGTGACCCTT	0.473000												
ASB4	51666	broad.mit.edu	37	7	95157511	95157511	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr7:95157511G>A	uc011kij.1	+	3	874	c.874G>A	c.(874-876)GTG>ATG	p.V292M	ASB4_uc003unx.2_Missense_Mutation_p.V292M	NM_016116	NP_057200	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box-containing protein 4	292					intracellular signal transduction					central_nervous_system(1)	1	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			CATCCAGTACGTGCTGAAGGT	0.587000											OREG0018172	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
WISP1	8840	broad.mit.edu	37	8	134233084	134233084	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr8:134233084G>A	uc003yub.2	+	3	686	c.610G>A	c.(610-612)GAT>AAT	p.D204N	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	204					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			AGGAGCCTTCGGTGGGTGTGG	0.617000												
FAM135B	51059	broad.mit.edu	37	8	139323096	139323096	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr8:139323096C>T	uc003yuy.2	-	3	316	c.145G>A	c.(145-147)GCT>ACT	p.A49T	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	49										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTCTGCCCAGCGATGGAGGCA	0.557000										HNSCC(54;0.14)		
TRPM3	80036	broad.mit.edu	37	9	73233887	73233887	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr9:73233887C>T	uc004aid.2	-	16	2462	c.2218G>A	c.(2218-2220)GTG>ATG	p.V740M	TRPM3_uc004ahu.2_Missense_Mutation_p.V570M|TRPM3_uc004ahv.2_Missense_Mutation_p.V542M|TRPM3_uc004ahw.2_Missense_Mutation_p.V612M|TRPM3_uc004ahx.2_Missense_Mutation_p.V599M|TRPM3_uc004ahy.2_Missense_Mutation_p.V602M|TRPM3_uc004ahz.2_Missense_Mutation_p.V589M|TRPM3_uc004aia.2_Missense_Mutation_p.V587M|TRPM3_uc004aib.2_Missense_Mutation_p.V577M|TRPM3_uc004aic.2_Missense_Mutation_p.V740M	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	765	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TTGGCAGCCACGGCAAGCTGC	0.607000												
CTNNAL1	8727	broad.mit.edu	37	9	111741743	111741743	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr9:111741743G>A	uc004bdo.1	-	7	961	c.919C>T	c.(919-921)CGG>TGG	p.R307W	CTNNAL1_uc010mts.1_Missense_Mutation_p.R43W|CTNNAL1_uc010mtt.1_Missense_Mutation_p.R307W|CTNNAL1_uc004bdp.1_Missense_Mutation_p.R307W	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	307					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		AGATTCTCCCGAAGAGCTTCA	0.418000												
FAM120C	54954	broad.mit.edu	37	X	54107882	54107882	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chrX:54107882T>C	uc004dsz.3	-	14	2934	c.2851A>G	c.(2851-2853)ATC>GTC	p.I951V	FAM120C_uc011moh.1_Silent_p.Q813Q	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	951										ovary(1)|central_nervous_system(1)	2						TGGGGTGGGATTGGATGGAGA	0.393000												
NAP1L2	4674	broad.mit.edu	37	X	72433514	72433514	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chrX:72433514A>T	uc004ebi.2	-	1	1171	c.815T>A	c.(814-816)ATT>AAT	p.I272N	NAP1L2_uc011mqj.1_Missense_Mutation_p.I130N	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	272					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					CTTAACTTTAATATCTGTCAG	0.363000												
DEPDC4	120863	broad.mit.edu	37	12	100660815	100660816	+	Frame_Shift_Ins	INS	-	-	C	rs142975288	by1000genomes	TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr12:100660814_100660815A>AC	uc009ztv.1	-	0	43_44	c.40_41T>GT	c.(40-42)gttfs	p.V14fs	SCYL2_uc009ztw.1_5'Flank|SCYL2_uc001thm.1_5'Flank|SCYL2_uc001thn.3_5'Flank|DEPDC4_uc001thh.1_Non-coding_Transcript|DEPDC4_uc001thi.3_Frame_Shift_Ins_p.V14fs|DEPDC4_uc001thj.1_Frame_Shift_Ins_p.V14fs|DEPDC4_uc001thk.1_5'UTR|DEPDC4_uc001thl.1_Non-coding_Transcript	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	Homo sapiens DEP domain containing 4 (DEPDC4), mRNA.	14					intracellular signal transduction					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)|urinary_tract(1)	15						AGTCAAAAGAACCGCCATAAGC	0.634												
RBBP6	5930	broad.mit.edu	37	16	24583197	24583198	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D7-8578-01A-21D-2340-08	TCGA-D7-8578-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4e5dfe9a-e9be-4fb5-b9f3-d41268dbfad3	33b49419-1891-4766-96fd-a54a188f70dc	g.chr16:24583196_24583197T>TA	uc002dmh.3	+	17	5849_5850	c.4809_4810T>TA	c.(4807-4812)attactfs	p.I1603fs	RBBP6_uc002dmi.3_Frame_Shift_Ins_p.I1569fs|RBBP6_uc010bxr.3_Frame_Shift_Ins_p.I763fs|RBBP6_uc002dmk.3_Frame_Shift_Ins_p.I1436fs	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	Homo sapiens retinoblastoma binding protein 6 (RBBP6), transcript variant 1, mRNA.	1603					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.Q1602R(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		AAGAGCAAATTACTGGGCAAAT	0.381