Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
SLC1A7	6512	broad.mit.edu	37	1	53558323	53558323	+	Silent	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr1:53558323G>A	uc001cuy.2	-	7	1102	c.934C>T	c.(934-936)CTG>TTG	p.L312L	SLC1A7_uc001cux.2_5'Flank	NM_006671	NP_006662	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter),	312	Helical; (Potential).					integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|large_intestine(1)	3				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	AGCAGGGGCAGGATAAAGAGC	0.592000												
CNN3	1266	broad.mit.edu	37	1	95367785	95367785	+	Silent	SNP	A	A	G			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr1:95367785A>G	uc010otw.1	-	5	358	c.276T>C	c.(274-276)GCT>GCC	p.A92A	CNN3_uc010otv.1_Silent_p.A51A|CNN3_uc001dqz.3_Silent_p.A92A|CNN3_uc010otx.1_Intron	NM_001839	NP_001830	Q15417	CNN3_HUMAN	calponin 3	92	CH.				actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		AAGCCTGAATAGCTTTAATAA	0.343000												
OLFML2B	25903	broad.mit.edu	37	1	161967627	161967627	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr1:161967627G>A	uc001gbu.2	-	6	1886	c.1462C>T	c.(1462-1464)CGG>TGG	p.R488W	OLFML2B_uc010pkq.1_Missense_Mutation_p.R489W	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	488										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			ATGACATTCCGGATGTCATCT	0.552000												
TNR	7143	broad.mit.edu	37	1	175292512	175292512	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr1:175292512C>T	uc001gkp.1	-	21	4139	c.4058G>A	c.(4057-4059)CGG>CAG	p.R1353Q	TNR_uc009wwu.1_Missense_Mutation_p.R1353Q	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1353					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TAAGGACTGCCGTTTTCTCCC	0.473000												
PPFIBP1	8496	broad.mit.edu	37	12	27841317	27841317	+	Silent	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr12:27841317G>A	uc001ric.1	+	25	2852	c.2475G>A	c.(2473-2475)GCG>GCA	p.A825A	PPFIBP1_uc010sjr.1_Silent_p.A656A|PPFIBP1_uc001rib.1_Silent_p.A819A|PPFIBP1_uc001ria.2_Silent_p.A794A|PPFIBP1_uc001rid.1_Silent_p.A672A|PPFIBP1_uc001rif.1_Silent_p.A332A	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	825	SAM 3.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CAGAATATGCGCCCAATCTCA	0.473000												
SLC17A8	246213	broad.mit.edu	37	12	100811871	100811871	+	Silent	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr12:100811871C>T	uc010svi.1	+	11	1675	c.1362C>T	c.(1360-1362)AAC>AAT	p.N454N	SLC17A8_uc009ztx.2_Silent_p.N404N	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	454	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						GGATCTCAAACGGAGTGGGAA	0.488000												
NRXN3	9369	broad.mit.edu	37	14	80271525	80271525	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr14:80271525C>T	uc001xun.2	+	16	3367	c.2876C>T	c.(2875-2877)CCG>CTG	p.P959L	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.P327L|NRXN3_uc010asw.2_Missense_Mutation_p.P357L|NRXN3_uc001xur.3_Missense_Mutation_p.P327L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1332	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GAATGTGAGCCGAGTACAGGT	0.333000												
ATP8B4	79895	broad.mit.edu	37	15	50223420	50223420	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr15:50223420C>T	uc001zxu.2	-	16	1680	c.1538G>A	c.(1537-1539)CGG>CAG	p.R513Q	ATP8B4_uc010ber.2_Missense_Mutation_p.R386Q|ATP8B4_uc010ufd.1_Intron|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	513	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTCTGGGGTCCGGGATTTAAA	0.398000												
IL16	3603	broad.mit.edu	37	15	81589340	81589340	+	Silent	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr15:81589340C>T	uc002bgh.3	+	13	2350	c.1974C>T	c.(1972-1974)GCC>GCT	p.A658A	IL16_uc010blq.1_Silent_p.A612A|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Silent_p.A700A|IL16_uc002bgg.2_Silent_p.A658A|IL16_uc002bgi.1_Silent_p.A48A|IL16_uc002bgj.2_Silent_p.A152A|IL16_uc002bgk.2_5'UTR|IL16_uc002bgl.1_5'UTR|IL16_uc010unq.1_5'Flank	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	658					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GTGCCTCTGCCGGCTGCCCAG	0.592000												
CNOT1	23019	broad.mit.edu	37	16	58619350	58619350	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr16:58619350T>G	uc002env.2	-	8	991	c.698A>C	c.(697-699)GAC>GCC	p.D233A	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.D233A|CNOT1_uc002enx.2_Missense_Mutation_p.D233A|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	233					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CATTAGAATGTCCCGTTTTTC	0.453000												
CDH1	999	broad.mit.edu	37	16	68842595	68842595	+	Splice_Site	SNP	G	G	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr16:68842595G>T	uc002ewg.1	+	5	656	c.532_splice	c.e5-1	p.I178_splice	CDH1_uc010vlj.1_Splice_Site|CDH1_uc010cfg.1_Splice_Site_p.I178_splice	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein						adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(4)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TTTGTCTTCAGATCAAATCCA	0.418000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
IMP5	162540	broad.mit.edu	37	17	43923555	43923555	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr17:43923555G>A	uc010wka.1	+	1	1283	c.1283G>A	c.(1282-1284)CGG>CAG	p.R428Q	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	428	Cytoplasmic (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		AAAGTGCCCCGGCTAAGAGTC	0.587000												
CACNA1G	8913	broad.mit.edu	37	17	48680542	48680542	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr17:48680542G>A	uc002irk.1	+	21	4523	c.4151G>A	c.(4150-4152)CGG>CAG	p.R1384Q	CACNA1G_uc002iri.1_Missense_Mutation_p.R1384Q|CACNA1G_uc002irj.1_Missense_Mutation_p.R1361Q|CACNA1G_uc002irl.1_Missense_Mutation_p.R1361Q|CACNA1G_uc002irm.1_Missense_Mutation_p.R1361Q|CACNA1G_uc002irn.1_Missense_Mutation_p.R1361Q|CACNA1G_uc002iro.1_Missense_Mutation_p.R1361Q|CACNA1G_uc002irp.1_Missense_Mutation_p.R1384Q|CACNA1G_uc002irq.1_Missense_Mutation_p.R1361Q|CACNA1G_uc002irr.1_Missense_Mutation_p.R1384Q|CACNA1G_uc002irs.1_Missense_Mutation_p.R1384Q|CACNA1G_uc002irt.1_Missense_Mutation_p.R1384Q|CACNA1G_uc002irv.1_Missense_Mutation_p.R1384Q|CACNA1G_uc002irw.1_Missense_Mutation_p.R1361Q|CACNA1G_uc002iru.1_Missense_Mutation_p.R1361Q|CACNA1G_uc002irx.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002iry.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002irz.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002isa.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002isb.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002isc.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002isd.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002ise.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002isf.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002isg.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002ish.1_Missense_Mutation_p.R1297Q|CACNA1G_uc002isi.1_Missense_Mutation_p.R1274Q|CACNA1G_uc002isj.2_Missense_Mutation_p.R108Q	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1384	III.|Helical; Name=S4 of repeat III; (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CGGCTGCTGCGGACCCTGCGC	0.657000												
ME2	4200	broad.mit.edu	37	18	48443718	48443718	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr18:48443718C>T	uc002ley.2	+	6	726	c.470C>T	c.(469-471)GCT>GTT	p.A157V	ME2_uc010dpd.2_Missense_Mutation_p.A157V	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	157					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	GTGATTAAGGCTGTTGTAGTG	0.338000												
CREB3L3	84699	broad.mit.edu	37	19	4154997	4154997	+	Silent	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr19:4154997C>T	uc002lzl.2	+	2	245	c.129C>T	c.(127-129)GGC>GGT	p.G43G	CREB3L3_uc002lzm.2_Silent_p.G34G|CREB3L3_uc010xib.1_Silent_p.G34G|CREB3L3_uc010xic.1_Silent_p.G34G	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	43	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGCTGGGCGAGGGCTGGG	0.642000												
RDH8	50700	broad.mit.edu	37	19	10129502	10129502	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr19:10129502C>A	uc002mmr.2	+	3	607	c.358C>A	c.(358-360)CGT>AGT	p.R120S		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	120					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	CGGAGCTGTCCGTCTCGTCAA	0.587000												
FOSL2	2355	broad.mit.edu	37	2	28635103	28635103	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr2:28635103G>A	uc002rma.2	+	4	1578	c.769G>A	c.(769-771)GGT>AGT	p.G257S	FOSL2_uc010ymi.1_Missense_Mutation_p.G218S	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	257					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					GGGCTTCTACGGTGAGGAGCC	0.647000												
RANBP2	5903	broad.mit.edu	37	2	109399073	109399073	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr2:109399073C>A	uc002tem.3	+	28	9250	c.9124C>A	c.(9124-9126)CAG>AAG	p.Q3042K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	3042	RanBD1 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AGAATGTCAGCAGAATTTAAT	0.398000												
C20orf194	25943	broad.mit.edu	37	20	3355774	3355774	+	Splice_Site	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr20:3355774C>T	uc002wii.2	-	5	460	c.409_splice	c.e5-1	p.Y137_splice	C20orf194_uc002wik.2_Splice_Site|C20orf194_uc010gay.1_Splice_Site	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943												0						CATCTTCATACTGAAGAGACA	0.383000												
CD93	22918	broad.mit.edu	37	20	23065099	23065099	+	Silent	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr20:23065099G>A	uc002wsv.2	-	1	1879	c.1731C>T	c.(1729-1731)GAC>GAT	p.D577D		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	577	Extracellular (Potential).				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCTTTTGCCCGTCAGTGCCAT	0.617000												
GNAS	2778	broad.mit.edu	37	20	57484421	57484421	+	Missense_Mutation	SNP	G	G	A	rs121913495		TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr20:57484421G>A	uc002xzw.2	+	8	2816	c.2531G>A	c.(2530-2532)CGT>CAT	p.R844H	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Missense_Mutation_p.R142H|GNAS_uc002xzx.2_Missense_Mutation_p.R142H|GNAS_uc010gjr.2_Missense_Mutation_p.R92H|GNAS_uc002xzy.2_Missense_Mutation_p.R127H|GNAS_uc002yaa.2_Missense_Mutation_p.R187H|GNAS_uc010zzt.1_Missense_Mutation_p.R202H|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Missense_Mutation_p.R92H|GNAS_uc002yae.2_Missense_Mutation_p.R126H	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	201	GTP (By similarity).		R -> L (in non-MAS endocrine tumors).|R -> S (in AIMAH, pituitary tumor and polyostotic fibrous dysplasia).|R -> H (in MAS, somatotrophinoma and AIMAH).|R -> G (in MAS).		activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity	p.R201H(37)|p.R201L(1)|p.R844H(1)		pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CTTCGCTGCCGTGTCCTGACT	0.423000			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)		
RHOA	387	broad.mit.edu	37	3	49405956	49405956	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr3:49405956G>T	uc003cwu.2	-	3	458	c.182C>A	c.(181-183)GCT>GAT	p.A61D	RHOA_uc010hku.2_Translation_Start_Site	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	61	GTP (By similarity).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	TTCCTGCCCAGCTGTGTCCCA	0.473000												
MYH15	22989	broad.mit.edu	37	3	108159995	108159995	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr3:108159995T>C	uc003dxa.1	-	24	2885	c.2828A>G	c.(2827-2829)GAG>GGG	p.E943G		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	943	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						AGAATTTATCTCCTCTTCTTC	0.478000												
MME	4311	broad.mit.edu	37	3	154886414	154886414	+	Silent	SNP	C	C	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr3:154886414C>T	uc010hvr.1	+	19	2125	c.1914C>T	c.(1912-1914)CAC>CAT	p.H638H	MME_uc003fab.1_Silent_p.H638H|MME_uc003fac.1_Silent_p.H638H|MME_uc003fad.1_Silent_p.H638H|MME_uc003fae.1_Silent_p.H638H	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	638	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GTGGACAGCACGTATGTCATT	0.383000												
CLCN2	1181	broad.mit.edu	37	3	184073198	184073198	+	Silent	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr3:184073198G>A	uc003foi.2	-	12	1414	c.1290C>T	c.(1288-1290)AAC>AAT	p.N430N	CLCN2_uc003foh.2_Translation_Start_Site|CLCN2_uc010hya.1_Silent_p.N430N|CLCN2_uc011brl.1_Silent_p.N430N|CLCN2_uc011brm.1_Silent_p.N386N|CLCN2_uc011brn.1_Silent_p.N430N	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	430	Helical; (By similarity).					chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	TGAGGAAGACGTTGGCACGTG	0.522000												
OR14J1	442191	broad.mit.edu	37	6	29274611	29274611	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr6:29274611G>A	uc011dln.1	+	1	145	c.145G>A	c.(145-147)GTG>ATG	p.V49M		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CATCATTACCGTGGACCGTCG	0.468000												
C6orf1	221491	broad.mit.edu	37	6	34214824	34214824	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr6:34214824G>A	uc003ojf.2	-	4	714	c.122C>T	c.(121-123)CCA>CTA	p.P41L	uc003oje.1_5'Flank|C6orf1_uc003ojg.2_Missense_Mutation_p.P41L|C6orf1_uc003ojh.2_Missense_Mutation_p.P41L|C6orf1_uc003oji.2_RNA	NM_178508	NP_848603	Q86T20	CF001_HUMAN	hypothetical protein LOC221491 precursor	41						extracellular region					0		Ovarian(999;0.0228)		BRCA - Breast invasive adenocarcinoma(397;1.11e-10)		TGCTCACCTTGGGGTCTCCCA	0.607000											OREG0017364	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
HSF2	3298	broad.mit.edu	37	6	122743424	122743424	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr6:122743424G>A	uc003pyu.2	+	8	998	c.811G>A	c.(811-813)GTT>ATT	p.V271I	HSF2_uc003pyv.2_Missense_Mutation_p.V271I	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	271					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		TAATGAGGATGTTATATCTGA	0.313000												
C7orf27	221927	broad.mit.edu	37	7	2594051	2594051	+	Silent	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr7:2594051G>A	uc003smi.2	-	2	57	c.15C>T	c.(13-15)TGC>TGT	p.C5C	C7orf27_uc003smj.1_Silent_p.C5C	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	5					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		GCAGCTGGGCGCATTCTGGGT	0.597000												
RABEPK	10244	broad.mit.edu	37	9	127990211	127990211	+	Silent	SNP	A	A	G			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr9:127990211A>G	uc004bpi.2	+	7	722	c.549A>G	c.(547-549)CCA>CCG	p.P183P	RABEPK_uc004bpj.2_Silent_p.P132P|RABEPK_uc004bpk.2_Silent_p.P183P|RABEPK_uc004bpl.1_Silent_p.P132P|RABEPK_uc004bpm.2_Silent_p.P183P	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	183	Kelch 3.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						GGTCACAGCCAGAGACACTTG	0.483000												
NHS	4810	broad.mit.edu	37	X	17745826	17745826	+	Silent	SNP	G	G	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chrX:17745826G>A	uc004cxx.2	+	6	3875	c.3537G>A	c.(3535-3537)CTG>CTA	p.L1179L	NHS_uc011mix.1_Silent_p.L1200L|NHS_uc004cxy.2_Silent_p.L1023L|NHS_uc004cxz.2_Silent_p.L1002L|NHS_uc004cya.2_Silent_p.L902L	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1179						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					ACACCATACTGTCCTTTTTAG	0.413000												
MAGEB10	139422	broad.mit.edu	37	X	27840218	27840218	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chrX:27840218C>A	uc004dbw.2	+	3	1022	c.795C>A	c.(793-795)AAC>AAA	p.N265K		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	265	MAGE.									lung(1)|breast(1)|central_nervous_system(1)	3						AAGTGCCCAACAGTGATCCTC	0.458000												
PCDH19	57526	broad.mit.edu	37	X	99551591	99551591	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chrX:99551591C>A	uc010nmz.2	-	6	4807	c.3131G>T	c.(3130-3132)TGC>TTC	p.C1044F	PCDH19_uc004efw.3_Missense_Mutation_p.C996F|PCDH19_uc004efx.3_Missense_Mutation_p.C997F	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	1044	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CTTGGGGCTGCAGATGGTCAC	0.592000												
PLA2G1B	5319	broad.mit.edu	37	12	120763700	120763701	+	Frame_Shift_Ins	INS	-	-	A	rs78096484		TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr12:120763699_120763700C>CA	uc001tyd.3	-	1	194_195	c.158_159G>TG	c.(157-159)ttgfs	p.L53fs	PLA2G1B_uc009zwx.3_Frame_Shift_Ins_p.L53fs	NM_000928	NP_000919	P04054	PA21B_HUMAN	Homo sapiens phospholipase A2, group IB (pancreas) (PLA2G1B), mRNA.	53					actin filament organization|activation of MAPK activity|activation of phospholipase A2 activity|arachidonic acid secretion|cellular response to insulin stimulus|glucose transport|interleukin-8 production|leukotriene biosynthetic process|multicellular organismal lipid catabolic process|neutrophil chemotaxis|neutrophil mediated immunity|phosphatidylcholine metabolic process|positive regulation of DNA replication|positive regulation of NF-kappaB transcription factor activity|positive regulation of calcium ion transport into cytosol|positive regulation of immune response|positive regulation of protein secretion|positive regulation of transcription from RNA polymerase II promoter	extracellular space	bile acid binding|calcium ion binding|calcium-dependent phospholipase A2 activity|cell surface binding|receptor binding			endometrium(1)|large_intestine(1)|lung(3)|skin(2)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTGAGCCCCCCAAGCCACAGTA	0.614											OREG0022189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
BZRAP1	9256	broad.mit.edu	37	17	56386384	56386385	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D7-8574-01A-13D-2340-08	TCGA-D7-8574-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8bb9319-5450-418d-874c-e117448cecfe	2c754412-22e7-471f-b5f7-a390110559b7	g.chr17:56386383_56386384C>CT	uc002ivx.4	-	21	5120_5121	c.4249_4250G>AG	c.(4249-4251)agcfs	p.S1417fs	BZRAP1_uc002ivw.3_5'Flank|BZRAP1_uc010dcs.3_Frame_Shift_Ins_p.S1357fs|BZRAP1_uc010wnt.2_Frame_Shift_Ins_p.S1417fs	NM_004758	NP_004749	O95153	RIMB1_HUMAN	Homo sapiens benzodiazapine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant 1, mRNA.	1417						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGCCTGCGGCTTGGGGGCTTC	0.653