Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CLSTN1	22883	broad.mit.edu	37	1	9809625	9809625	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:9809625G>C	uc001aqh.2	-	7	1638	c.879C>G	c.(877-879)GAC>GAG	p.D293E	CLSTN1_uc001aqi.2_Missense_Mutation_p.D283E|CLSTN1_uc010oag.1_Missense_Mutation_p.D293E	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	293	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		CGACTGGCTCGTCACATGTCT	0.572000												
CLCNKA	1187	broad.mit.edu	37	1	16359716	16359716	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:16359716C>T	uc001axu.2	+	19	2061	c.1981C>T	c.(1981-1983)CGG>TGG	p.R661W	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.R660W|CLCNKA_uc010obw.1_Missense_Mutation_p.R618W|CLCNKB_uc001axw.3_Intron	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	661	CBS 2.				excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CGTGACATCGCGGGGCAGAGC	0.612000											OREG0013132	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
ASH1L	55870	broad.mit.edu	37	1	155408474	155408474	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:155408474G>A	uc009wqq.2	-	5	5952	c.5472C>T	c.(5470-5472)GAC>GAT	p.D1824D	ASH1L_uc001fkt.2_Silent_p.D1824D	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1824					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TATTGACATGGTCTAGGTTTT	0.448000												
SPTA1	6708	broad.mit.edu	37	1	158623116	158623116	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:158623116G>A	uc001fst.1	-	22	3335	c.3136C>T	c.(3136-3138)CGA>TGA	p.R1046*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1046					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCTTCTCGTCGCCGCTGTGGG	0.537000												
LRRC52	440699	broad.mit.edu	37	1	165513859	165513859	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:165513859G>C	uc001gde.2	+	1	382	c.326G>C	c.(325-327)AGC>ACC	p.S109T	LOC400794_uc001gdc.2_Intron|LOC400794_uc001gdd.2_Intron|LOC400794_uc009wvd.2_Intron	NM_001005214	NP_001005214	Q8N7C0	LRC52_HUMAN	leucine rich repeat containing 52 precursor	109	LRR 3.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)					CTTGACCTCAGCTCCAACAAC	0.488000												
DSTYK	25778	broad.mit.edu	37	1	205132996	205132996	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:205132996C>T	uc001hbw.2	-	4	1476	c.1412G>A	c.(1411-1413)CGA>CAA	p.R471Q	DSTYK_uc001hbx.2_Missense_Mutation_p.R471Q|DSTYK_uc001hby.1_Intron	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	471						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						CTGATTAAGTCGGGAGATGAT	0.512000												
TRAF3IP3	80342	broad.mit.edu	37	1	209933511	209933511	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:209933511C>T	uc001hho.2	+	3	417	c.127C>T	c.(127-129)CGC>TGC	p.R43C	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.R43C|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.R43C|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.R43C|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.R43C	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	43	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		GACCACTTGCCGCCAGGTGGG	0.612000												
CENPF	1063	broad.mit.edu	37	1	214818018	214818018	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:214818018T>A	uc001hkm.2	+	13	5279	c.5105T>A	c.(5104-5106)CTC>CAC	p.L1702H		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1798					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CAGCAGGACCTCAATCTAGAC	0.438000												
TLR5	7100	broad.mit.edu	37	1	223285526	223285526	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:223285526G>C	uc001hnv.1	-	4	1294	c.848C>G	c.(847-849)GCT>GGT	p.A283G	TLR5_uc001hnw.1_Missense_Mutation_p.A283G	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	283	Extracellular (Potential).				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		GGCCAGGCCAGCAAATGTGTT	0.483000												
ZWINT	11130	broad.mit.edu	37	10	58120068	58120068	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr10:58120068C>G	uc001jjx.1	-	2	155	c.118G>C	c.(118-120)GTT>CTT	p.V40L	ZWINT_uc001jjy.1_Missense_Mutation_p.V40L|ZWINT_uc001jka.1_Missense_Mutation_p.V40L|ZWINT_uc009xoy.1_RNA	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	40					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0						ACAAACTCAACCAGGATCTTG	0.572000												
HK1	3098	broad.mit.edu	37	10	71142523	71142523	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr10:71142523G>A	uc001jpl.3	+	10	1647	c.1546G>A	c.(1546-1548)GTC>ATC	p.V516I	HK1_uc001jpg.3_Missense_Mutation_p.V504I|HK1_uc001jph.3_Missense_Mutation_p.V520I|HK1_uc001jpi.3_Missense_Mutation_p.V520I|HK1_uc001jpj.3_Missense_Mutation_p.V551I|HK1_uc001jpk.3_Missense_Mutation_p.V515I|HK1_uc009xqd.2_Missense_Mutation_p.V394I	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	516	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						GCCCTCCTTCGTCCGGAGAAC	0.632000												
SAR1A	56681	broad.mit.edu	37	10	71921409	71921409	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr10:71921409G>C	uc010qjh.1	-	4	347	c.144C>G	c.(142-144)GAC>GAG	p.D48E	SAR1A_uc010qji.1_Missense_Mutation_p.D48E|SAR1A_uc010qjj.1_Missense_Mutation_p.D5E	NM_001142648	NP_001136120	Q9NR31	SAR1A_HUMAN	SAR1a gene homolog 1	48					ER to Golgi vesicle-mediated transport|intracellular protein transport	Golgi apparatus	GTP binding|GTPase activity				0						GGCCCAATCTGTCATCTTTGA	0.388000												
BTAF1	9044	broad.mit.edu	37	10	93753597	93753597	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr10:93753597T>A	uc001khr.2	+	22	3290	c.3192T>A	c.(3190-3192)AAT>AAA	p.N1064K	BTAF1_uc001kht.1_Missense_Mutation_p.N502K	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1064					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TCGACATAAATAATTTTGGTA	0.323000												
RBP4	5950	broad.mit.edu	37	10	95360237	95360237	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr10:95360237C>T	uc001kit.2	-	4	352	c.268G>A	c.(268-270)GAC>AAC	p.D90N		NM_006744	NP_006735	P02753	RET4_HUMAN	retinol-binding protein 4, plasma precursor	90					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding				0		Colorectal(252;0.122)			Vitamin A(DB00162)	CCCACCATGTCTGCGCACACG	0.582000												
ABCC2	1244	broad.mit.edu	37	10	101590129	101590129	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr10:101590129G>A	uc001kqf.2	+	20	2825	c.2686G>A	c.(2686-2688)GAA>AAA	p.E896K		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	896	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AGAGATCCCCGAAGATGCAGC	0.507000												
GFRA1	2674	broad.mit.edu	37	10	117884945	117884945	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr10:117884945A>G	uc001lcj.2	-	6	1255	c.557T>C	c.(556-558)GTC>GCC	p.V186A	GFRA1_uc001lci.2_Missense_Mutation_p.V181A|GFRA1_uc009xyr.2_Missense_Mutation_p.V181A	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	186	2.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		GCGGTTGCAGACATCGTTGGA	0.597000												
NKX6-2	84504	broad.mit.edu	37	10	134598811	134598811	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr10:134598811C>T	uc001llr.2	-	2	637	c.552G>A	c.(550-552)TCG>TCA	p.S184S		NM_177400	NP_796374	Q9C056	NKX62_HUMAN	NK6 transcription factor related, locus 2	184	Homeobox.					nucleus	sequence-specific DNA binding transcription factor activity				0		all_cancers(35;2.79e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0584)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;4.06e-05)|Epithelial(32;5.53e-05)|all cancers(32;5.99e-05)		TCATGCCCAGCGAGTAGGCGA	0.692000												
MUC5B	727897	broad.mit.edu	37	11	1155765	1155765	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:1155765C>T	uc009ycr.1	+	5	579	c.453C>T	c.(451-453)TCC>TCT	p.S151S		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	147	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCAAGGGCTCCGTCCTGGTCA	0.662000												
LIN7C	55327	broad.mit.edu	37	11	27528282	27528282	+	Silent	SNP	T	T	C	rs142535769	by1000genomes	TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:27528282T>C	uc001mrl.2	-	1	45	c.18A>G	c.(16-18)GAA>GAG	p.E6E	LIN7C_uc009yii.2_Silent_p.E6E|BDNFOS_uc001mrm.2_5'Flank|BDNFOS_uc009yij.2_5'Flank|BDNFOS_uc009yik.2_5'Flank|BDNFOS_uc009yil.2_5'Flank|BDNFOS_uc001mrp.2_5'Flank|BDNFOS_uc009yim.2_5'Flank|BDNFOS_uc009yin.2_5'Flank|BDNFOS_uc009yio.2_5'Flank|BDNFOS_uc009yip.2_5'Flank|BDNFOS_uc001mrn.2_5'Flank|BDNFOS_uc009yiq.2_5'Flank|BDNFOS_uc001mro.2_5'Flank|BDNFOS_uc009yir.2_5'Flank|BDNFOS_uc009yis.2_5'Flank|BDNFOS_uc009yit.2_5'Flank|BDNFOS_uc009yiu.2_5'Flank|BDNFOS_uc009yiv.2_5'Flank|BDNFOS_uc009yiw.2_5'Flank|BDNFOS_uc009yix.2_5'Flank|BDNFOS_uc009yiy.2_5'Flank|BDNFOS_uc009yiz.2_5'Flank|BDNFOS_uc001mrq.3_5'Flank|BDNFOS_uc001mrr.3_5'Flank|BDNFOS_uc009yja.2_5'Flank|BDNFOS_uc009yjb.2_5'Flank	NM_018362	NP_060832	Q9NUP9	LIN7C_HUMAN	lin-7 homolog C	6	Kinase interacting site (By similarity).				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction					0						GCCGCACGGGTTCCCCTAGCG	0.662000												
PTPRJ	5795	broad.mit.edu	37	11	48177352	48177352	+	Splice_Site	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:48177352G>C	uc001ngp.3	+	20	3585	c.3230_splice	c.e20-1	p.Y1077_splice		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J						contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						TAATGTCACAGATGATATTTC	0.388000												
MS4A15	219995	broad.mit.edu	37	11	60531284	60531284	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:60531284G>A	uc009ynf.1	+	2	298	c.78G>A	c.(76-78)CCG>CCA	p.P26P	MS4A15_uc001npx.2_Intron|MS4A15_uc001npy.2_RNA|MS4A15_uc009yng.1_Silent_p.P26P	NM_001098835	NP_001092305	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member	26						integral to membrane	receptor activity			lung(1)	1						GCCCACCTCCGGCCATTCTGC	0.602000												
SCGB2A2	4250	broad.mit.edu	37	11	62037723	62037723	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:62037723T>A	uc001ntc.2	+	1	94	c.35T>A	c.(34-36)CTC>CAC	p.L12H	SCGB2A2_uc009ynx.2_Missense_Mutation_p.L12H	NM_002411	NP_002402	Q13296	SG2A2_HUMAN	secretoglobin, family 2A, member 2 precursor	12						extracellular region	steroid binding			ovary(1)	1						CTGGCGGCCCTCTCCCAGCAC	0.607000												
RSF1	51773	broad.mit.edu	37	11	77409649	77409649	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:77409649G>A	uc001oyn.2	-	7	2718	c.2598C>T	c.(2596-2598)GGC>GGT	p.G866G	RSF1_uc001oym.2_Silent_p.G614G	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	866					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			ATTTTTCACTGCCAGACCCTT	0.433000												
KCTD21	283219	broad.mit.edu	37	11	77884828	77884828	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:77884828C>A	uc001ozb.2	-	2	848	c.773G>T	c.(772-774)CGG>CTG	p.R258L		NM_001029859	NP_001025030	Q4G0X4	KCD21_HUMAN	potassium channel tetramerisation domain	258						voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.46e-24)			TTACCTGTACCGTATTAATCG	0.498000												
GRM5	2915	broad.mit.edu	37	11	88781018	88781018	+	Nonsense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:88781018G>C	uc001pcq.2	-	1	223	c.23C>G	c.(22-24)TCA>TGA	p.S8*	GRM5_uc009yvm.2_Nonsense_Mutation_p.S8*|GRM5_uc009yvn.1_Nonsense_Mutation_p.S8*	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	8					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AAGTAAGACTGACAGGATCAA	0.473000												
SESN3	143686	broad.mit.edu	37	11	94923017	94923017	+	Silent	SNP	T	T	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:94923017T>G	uc001pfk.1	-	4	673	c.451A>C	c.(451-453)AGA>CGA	p.R151R	SESN3_uc010rug.1_Intron|SESN3_uc001pfl.2_Silent_p.R151R	NM_144665	NP_653266	P58005	SESN3_HUMAN	sestrin 3	151					cell cycle arrest	nucleus					0		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		TTTTTCAGTCTTTGTGGCACA	0.348000												
BIRC2	329	broad.mit.edu	37	11	102220931	102220931	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:102220931C>G	uc001pgy.2	+	2	1745	c.346C>G	c.(346-348)CTG>GTG	p.L116V	BIRC2_uc010ruq.1_Missense_Mutation_p.L67V|BIRC2_uc010rur.1_Missense_Mutation_p.L116V	NM_001166	NP_001157	Q13490	BIRC2_HUMAN	baculoviral IAP repeat-containing protein 2	116					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		TATTCAGAATCTGGTTTCAGC	0.413000												
BCL9L	283149	broad.mit.edu	37	11	118771876	118771876	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:118771876A>G	uc001pug.2	-	6	3541	c.2576T>C	c.(2575-2577)ATG>ACG	p.M859T	BCL9L_uc009zal.2_Missense_Mutation_p.M854T	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	859					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GTCCTGGGACATGGCTTGGTA	0.602000												
SORL1	6653	broad.mit.edu	37	11	121495981	121495981	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:121495981G>C	uc001pxx.2	+	46	6439	c.6359G>C	c.(6358-6360)GGG>GCG	p.G2120A	SORL1_uc010rzp.1_Missense_Mutation_p.G966A|SORL1_uc010rzq.1_Missense_Mutation_p.G735A	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	2120	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GATGAGCTGGGGTCTGGTGAG	0.473000												
NTF3	4908	broad.mit.edu	37	12	5603686	5603686	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:5603686G>A	uc001qnl.3	+	1	389	c.306G>A	c.(304-306)CCG>CCA	p.P102P	NTF3_uc001qnk.3_Silent_p.P115P	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	102					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						ACAACTCACCGCGGGTCCTGC	0.642000												
TAS2R20	259295	broad.mit.edu	37	12	11150144	11150144	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:11150144C>T	uc001qzm.2	-	1	331	c.331G>A	c.(331-333)GTC>ATC	p.V111I	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176889	NP_795370	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	111	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						GAGAAATTGACGATCTTGAGC	0.358000												
PLBD1	79887	broad.mit.edu	37	12	14664633	14664633	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:14664633G>C	uc001rcc.1	-	7	1018	c.857C>G	c.(856-858)TCT>TGT	p.S286C		NM_024829	NP_079105	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	286					lipid catabolic process	extracellular region	hydrolase activity				0						ATCATCCAGAGACTCCAAAAA	0.373000												
MLL2	8085	broad.mit.edu	37	12	49421805	49421805	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:49421805T>A	uc001rta.3	-	46	14502	c.14502A>T	c.(14500-14502)GAA>GAT	p.E4834D		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4834					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GACCCTCAGCTTCCCCCTTCT	0.612000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)		
PFDN5	5204	broad.mit.edu	37	12	53689700	53689700	+	Silent	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:53689700G>C	uc001scl.2	+	2	267	c.150G>C	c.(148-150)CTG>CTC	p.L50L	PFDN5_uc001scm.2_Intron|PFDN5_uc001scn.2_RNA|PFDN5_uc001sco.2_RNA	NM_002624	NP_002615	Q99471	PFD5_HUMAN	prefoldin subunit 5 isoform alpha	50					'de novo' posttranslational protein folding|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent	nucleus|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)	1						AGGACTGTCTGAACGTGCTGA	0.537000												
OS9	10956	broad.mit.edu	37	12	58090082	58090082	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:58090082C>T	uc001spj.2	+	5	564	c.505C>T	c.(505-507)CGC>TGC	p.R169C	OS9_uc010srx.1_Intron|OS9_uc001spk.2_Missense_Mutation_p.R169C|OS9_uc001spl.2_Missense_Mutation_p.R169C|OS9_uc001spm.2_Missense_Mutation_p.R169C|OS9_uc001spn.2_Missense_Mutation_p.R169C|OS9_uc010sry.1_Intron|OS9_uc010srz.1_Missense_Mutation_p.R110C	NM_006812	NP_006803	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum	169	PRKCSH.				ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			ovary(1)	1	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TCGTCTTAAACGCTACCACAG	0.562000												
TSFM	10102	broad.mit.edu	37	12	58176625	58176625	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:58176625G>A	uc001sqi.2	+	1	90	c.41G>A	c.(40-42)CGG>CAG	p.R14Q	TSFM_uc010sse.1_5'UTR|TSFM_uc001sqh.2_Missense_Mutation_p.R14Q|TSFM_uc010ssf.1_Missense_Mutation_p.R14Q	NM_005726	NP_005717	P43897	EFTS_HUMAN	Ts translation elongation factor, mitochondrial	14					regulation of transcription elongation, DNA-dependent	mitochondrion|nucleus	translation elongation factor activity				0	all_cancers(7;6.31e-80)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CTGGTCGCGCGGACCGGGAGC	0.642000											OREG0021954	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
IRAK3	11213	broad.mit.edu	37	12	66638317	66638317	+	Silent	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:66638317C>G	uc001sth.2	+	9	1041	c.939C>G	c.(937-939)GCC>GCG	p.A313A	IRAK3_uc010ssy.1_Silent_p.A252A	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	313	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		CTGATTTTGCCATGGCACACT	0.408000												
NCOR2	9612	broad.mit.edu	37	12	124827739	124827739	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:124827739C>T	uc010tba.1	-	33	4889	c.4772G>A	c.(4771-4773)CGA>CAA	p.R1591Q	NCOR2_uc010tay.1_Missense_Mutation_p.R1590Q|NCOR2_uc010taz.1_Missense_Mutation_p.R1574Q|NCOR2_uc010tbb.1_Missense_Mutation_p.R1583Q|NCOR2_uc010tbc.1_Missense_Mutation_p.R1573Q	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1591					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CGTCAGCTTTCGGTCCTGGGA	0.632000												
POLE	5426	broad.mit.edu	37	12	133209266	133209266	+	Silent	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr12:133209266C>G	uc001uks.1	-	44	6164	c.6120G>C	c.(6118-6120)GCG>GCC	p.A2040A	POLE_uc001ukq.1_Silent_p.A250A|POLE_uc001ukr.1_Silent_p.A844A|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	2040					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GGGCTCCGACCGCCCCCTCGG	0.657000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage				
SGCG	6445	broad.mit.edu	37	13	23824841	23824841	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr13:23824841G>A	uc001uom.2	+	4	525	c.370G>A	c.(370-372)GGC>AGC	p.G124S	SGCG_uc009zzv.2_Missense_Mutation_p.G124S|SGCG_uc009zzw.2_Missense_Mutation_p.G124S	NM_000231	NP_000222	Q13326	SGCG_HUMAN	gamma sarcoglycan	124	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0		all_cancers(29;4.34e-23)|all_epithelial(30;4.4e-19)|all_lung(29;2.45e-18)|Lung SC(185;0.0228)|Breast(139;0.188)		all cancers(112;0.00255)|Epithelial(112;0.0129)|OV - Ovarian serous cystadenocarcinoma(117;0.0365)|Lung(94;0.205)		GGAGGTCACAGGCAGGTTAAA	0.403000												
B3GALTL	145173	broad.mit.edu	37	13	31891748	31891748	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr13:31891748G>A	uc010aaz.2	+	13	1220	c.1110G>A	c.(1108-1110)GAG>GAA	p.E370E	B3GALTL_uc001utn.3_RNA	NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	370	Lumenal (Potential).				fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		ACTCCGGCGAGCCTGTGTTTC	0.507000												
COG6	57511	broad.mit.edu	37	13	40251606	40251606	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr13:40251606C>T	uc001uxh.2	+	5	530	c.430C>T	c.(430-432)CAA>TAA	p.Q144*	COG6_uc001uxi.2_Nonsense_Mutation_p.Q92*|COG6_uc010acb.2_Nonsense_Mutation_p.Q144*	NM_020751	NP_065802	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6 isoform	144					protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		AAATTACAGCCAAAAATTAGA	0.333000												
PCDH20	64881	broad.mit.edu	37	13	61987362	61987362	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr13:61987362G>C	uc001vid.3	-	2	1234	c.870C>G	c.(868-870)ATC>ATG	p.I290M	PCDH20_uc010thj.1_Missense_Mutation_p.I290M	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	263	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CCTCAGCTATGATGATGCTCA	0.527000												
SLC7A8	23428	broad.mit.edu	37	14	23652065	23652065	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr14:23652065T>A	uc001wiz.2	-	1	785	c.59A>T	c.(58-60)GAG>GTG	p.E20V	SLC7A8_uc010akj.2_Missense_Mutation_p.E20V	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	20					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	GGCGTCCGACTCGCCCCCACC	0.572000												
CMTM5	116173	broad.mit.edu	37	14	23848585	23848585	+	Silent	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr14:23848585C>G	uc010akm.2	+	5	1095	c.651C>G	c.(649-651)GCC>GCG	p.A217A	CMTM5_uc001wjs.2_Silent_p.A150A|CMTM5_uc001wjt.2_Silent_p.A119A|CMTM5_uc010akn.2_Silent_p.A112A|CMTM5_uc001wju.2_Silent_p.A99A|CMTM5_uc010ako.2_RNA	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	217					chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		CACCCGGGGCCAGCCAGGGTG	0.587000												
G2E3	55632	broad.mit.edu	37	14	31071327	31071327	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr14:31071327G>C	uc001wqk.2	+	10	1154	c.1000G>C	c.(1000-1002)GAT>CAT	p.D334H	G2E3_uc010tpe.1_Missense_Mutation_p.D249H|G2E3_uc010tpf.1_Missense_Mutation_p.D288H	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	334					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						CCAGAGTAAAGATCTACTGAG	0.328000												
PSMC1	5700	broad.mit.edu	37	14	90735757	90735757	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr14:90735757G>A	uc001xyf.2	+	9	946	c.898G>A	c.(898-900)GGT>AGT	p.G300S	PSMC1_uc001xyg.2_Missense_Mutation_p.G227S|PSMC1_uc001xyh.2_Missense_Mutation_p.G227S	NM_002802	NP_002793	P62191	PRS4_HUMAN	proteasome 26S ATPase subunit 1	300					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0		all_cancers(154;0.142)		COAD - Colon adenocarcinoma(157;0.21)		CTCCAATTCTGGTGGTGAGAG	0.428000												
UBE3A	7337	broad.mit.edu	37	15	25616254	25616254	+	Missense_Mutation	SNP	C	C	T	rs140204238		TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr15:25616254C>T	uc001zaq.2	-	4	1076	c.1076G>A	c.(1075-1077)CGA>CAA	p.R359Q	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.R336Q|UBE3A_uc001zas.2_Missense_Mutation_p.R356Q|UBE3A_uc001zat.2_Missense_Mutation_p.R336Q	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	359				R -> RNLVNEFNSR (in Ref. 7; AA sequence).	brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		CACTAGATTTCGACTGTTAAA	0.383000												
IVD	3712	broad.mit.edu	37	15	40703835	40703835	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr15:40703835C>G	uc001zls.3	+	6	975	c.641C>G	c.(640-642)ACA>AGA	p.T214R	IVD_uc001zlq.2_Missense_Mutation_p.T184R	NM_002225	NP_002216	P26440	IVD_HUMAN	isovaleryl Coenzyme A dehydrogenase isoform 1	211					leucine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|isovaleryl-CoA dehydrogenase activity			ovary(1)	1		all_cancers(109;1.19e-18)|all_epithelial(112;1.52e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0808)		TATGCCAAGACAGATCTGGCT	0.537000												
BAHD1	22893	broad.mit.edu	37	15	40751171	40751171	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr15:40751171C>T	uc001zlu.2	+	2	579	c.508C>T	c.(508-510)CGG>TGG	p.R170W	BAHD1_uc001zlt.2_Missense_Mutation_p.R170W|BAHD1_uc010bbp.1_Missense_Mutation_p.R170W|BAHD1_uc001zlv.2_Missense_Mutation_p.R170W	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	170					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CTCCAAGAAGCGGCCCCGGCT	0.687000												
SPG11	80208	broad.mit.edu	37	15	44888535	44888535	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr15:44888535A>C	uc001ztx.2	-	25	4211	c.4180T>G	c.(4180-4182)TAC>GAC	p.Y1394D	SPG11_uc010ueh.1_Missense_Mutation_p.Y1394D|SPG11_uc010uei.1_Missense_Mutation_p.Y1394D|SPG11_uc001zty.1_Missense_Mutation_p.Y123D	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1394	Cytoplasmic (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GGGCTGAAGTACTGGATAAGG	0.438000												
CACNA1H	8912	broad.mit.edu	37	16	1245993	1245993	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr16:1245993C>T	uc002cks.2	+	5	861	c.613C>T	c.(613-615)CGG>TGG	p.R205W	CACNA1H_uc002ckt.2_Missense_Mutation_p.R205W	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	205	Helical; Name=S4 of repeat I; (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCGGGTGCTGCGGCCCCTCCG	0.657000												
A2BP1	54715	broad.mit.edu	37	16	7568355	7568355	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr16:7568355G>A	uc002cys.2	+	5	1222	c.234G>A	c.(232-234)GCG>GCA	p.A78A	A2BP1_uc010buf.1_Silent_p.A78A|A2BP1_uc002cyr.1_Silent_p.A78A|A2BP1_uc002cyt.2_Silent_p.A78A|A2BP1_uc010uxz.1_Silent_p.A121A|A2BP1_uc010uya.1_Silent_p.A114A|A2BP1_uc002cyv.1_Silent_p.A78A|A2BP1_uc010uyb.1_Silent_p.A78A|A2BP1_uc002cyw.2_Silent_p.A98A|A2BP1_uc002cyy.2_Silent_p.A98A|A2BP1_uc002cyx.2_Silent_p.A98A|A2BP1_uc010uyc.1_Silent_p.A98A	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	78					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		AGAGCCCGGCGGACACGAGCG	0.652000												
ARHGAP17	55114	broad.mit.edu	37	16	24942523	24942523	+	Silent	SNP	C	C	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr16:24942523C>A	uc002dnb.2	-	19	2190	c.2097G>T	c.(2095-2097)CGG>CGT	p.R699R	ARHGAP17_uc002dmx.2_5'UTR|ARHGAP17_uc002dmw.2_5'UTR|ARHGAP17_uc002dmy.2_Silent_p.R144R|ARHGAP17_uc002dmz.2_Silent_p.R223R|ARHGAP17_uc002dna.2_Silent_p.R426R|ARHGAP17_uc002dnc.2_Silent_p.R621R|ARHGAP17_uc010vcf.1_Silent_p.R442R|ARHGAP17_uc002dne.1_5'UTR	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	699	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		TGGAGTACCTCCGGGGTGCTG	0.667000												
MT1M	4499	broad.mit.edu	37	16	56667294	56667294	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr16:56667294G>A	uc002ejn.2	+	2	181	c.71G>A	c.(70-72)TGC>TAC	p.C24Y	MT1A_uc002eji.2_Intron|MT1M_uc010vhe.1_RNA|uc002ejo.1_5'Flank|uc002ejp.1_5'Flank	NM_176870	NP_789846	Q8N339	MT1M_HUMAN	metallothionein 1M	24	Beta.	Divalent metal cation; cluster B.					metal ion binding			ovary(1)	1						TGCAAAGAGTGCAAATGCACC	0.577000												
CDH8	1006	broad.mit.edu	37	16	61687567	61687567	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr16:61687567C>T	uc002eog.1	-	12	2597	c.2345G>A	c.(2344-2346)CGC>CAC	p.R782H		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	782	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TCTCTTAAAGCGGGGACCCCA	0.473000												
PDPR	55066	broad.mit.edu	37	16	70190507	70190507	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr16:70190507A>T	uc002eyf.1	+	19	3322	c.2365A>T	c.(2365-2367)ATT>TTT	p.I789F	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.I689F|PDPR_uc002eyg.1_Missense_Mutation_p.I456F|PDPR_uc002eyh.2_Missense_Mutation_p.I134F|PDPR_uc010vls.1_Missense_Mutation_p.I134F	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	789					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		GGGAGAGCCCATTTACCGGAA	0.532000												
CAMTA2	23125	broad.mit.edu	37	17	4873788	4873788	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:4873788G>A	uc002gah.1	-	17	2960	c.2852C>T	c.(2851-2853)CCG>CTG	p.P951L	SPAG7_uc002gae.2_5'Flank|SPAG7_uc002gaf.2_5'Flank|CAMTA2_uc010cku.1_Missense_Mutation_p.P974L|CAMTA2_uc002gag.1_Missense_Mutation_p.P950L|CAMTA2_uc002gai.1_Missense_Mutation_p.P953L|CAMTA2_uc010ckv.1_Missense_Mutation_p.P598L	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	951					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						AATCCGCTCCGGTGTGGCTTC	0.607000												
DNAH2	146754	broad.mit.edu	37	17	7662770	7662770	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:7662770C>T	uc002giu.1	+	15	2493	c.2479C>T	c.(2479-2481)CGG>TGG	p.R827W		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	827	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTACATGATTCGGCTGGACCG	0.522000												
DNAH9	1770	broad.mit.edu	37	17	11774939	11774939	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:11774939G>A	uc002gne.2	+	52	10146	c.10078G>A	c.(10078-10080)GTG>ATG	p.V3360M	DNAH9_uc010coo.2_Missense_Mutation_p.V2654M	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3360					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTCTGAAAACGTGAGGTGGGC	0.473000												
NUFIP2	57532	broad.mit.edu	37	17	27614063	27614063	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:27614063C>T	uc002hdy.3	-	2	1038	c.949G>A	c.(949-951)GAT>AAT	p.D317N	NUFIP2_uc002hdx.3_Intron	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	317						nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			TTGGGCCGATCATCAAACTTT	0.493000												
KRT12	3859	broad.mit.edu	37	17	39023097	39023097	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:39023097C>T	uc002hvk.2	-	1	366	c.342G>A	c.(340-342)TCG>TCA	p.S114S		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	114	Head.|Gly-rich.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CATCATTGCCCGAGAGAATAC	0.512000												
WNK4	65266	broad.mit.edu	37	17	40935985	40935985	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:40935985G>A	uc002ibj.2	+	3	843	c.822G>A	c.(820-822)CCG>CCA	p.P274P	WNK4_uc010wgx.1_5'UTR|WNK4_uc002ibk.1_Silent_p.P46P|WNK4_uc010wgy.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	274	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		AGATGAAGCCGCGGGTCCTTC	0.652000												
GFAP	2670	broad.mit.edu	37	17	42989090	42989090	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:42989090G>A	uc002ihq.2	-	5	916	c.856C>T	c.(856-858)CGG>TGG	p.R286W	GFAP_uc002ihr.2_Missense_Mutation_p.R286W|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	286	Coil 2B.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				AACTGGCGCCGGTAGTCGTTG	0.692000												
FMNL1	752	broad.mit.edu	37	17	43320665	43320665	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:43320665C>T	uc002iin.2	+	17	2391	c.2191C>T	c.(2191-2193)CGC>TGC	p.R731C	FMNL1_uc002iiq.2_Missense_Mutation_p.R309C|FMNL1_uc010dag.2_RNA	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	731	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						GGGGGCCGAGCGCATCTGCCA	0.617000												
ABCA10	10349	broad.mit.edu	37	17	67212089	67212089	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:67212089C>G	uc010dfa.1	-	9	1604	c.725G>C	c.(724-726)GGT>GCT	p.G242A	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'Flank|ABCA10_uc010dfc.1_Missense_Mutation_p.G134A	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	242	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TCCAGCCAAACCAGCGAGCAT	0.383000												
TMC8	147138	broad.mit.edu	37	17	76129507	76129507	+	Silent	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:76129507C>G	uc002jup.2	+	6	934	c.552C>G	c.(550-552)CTC>CTG	p.L184L	TMC6_uc002jul.1_5'Flank|TMC8_uc002juq.2_5'UTR|TMC8_uc010wtr.1_5'Flank	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	184	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			ACACCTATCTCTTCTACGGTG	0.498000									Epidermodysplasia_Verruciformis_Familial_Clustering_of			
SOCS3	9021	broad.mit.edu	37	17	76354545	76354545	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:76354545G>A	uc002jvl.2	-	2	1048	c.632C>T	c.(631-633)CCG>CTG	p.P211L		NM_003955	NP_003946	O14543	SOCS3_HUMAN	suppressor of cytokine signaling 3	211	SOCS box.				anti-apoptosis|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|regulation of growth|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol	protein kinase inhibitor activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.000688)|OV - Ovarian serous cystadenocarcinoma(97;0.0554)			AATGGGCCCCGGCAGCTGGGT	0.632000												
MUC16	94025	broad.mit.edu	37	19	9087354	9087354	+	Silent	SNP	A	A	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:9087354A>G	uc002mkp.2	-	1	4665	c.4461T>C	c.(4459-4461)GCT>GCC	p.A1487A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1487	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGAAAAATAGCAAATGTAC	0.438000												
FAM129C	199786	broad.mit.edu	37	19	17644500	17644500	+	Silent	SNP	T	T	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:17644500T>A	uc010xpr.1	+	5	648	c.510T>A	c.(508-510)CCT>CCA	p.P170P	FAM129C_uc010xpq.1_Silent_p.P170P|FAM129C_uc010xps.1_Silent_p.P139P|FAM129C_uc010xpt.1_RNA	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	170											0						CTCTCTGCCCTGAATCCTTGG	0.393000												
TMEM149	79713	broad.mit.edu	37	19	36231285	36231285	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:36231285C>T	uc002obc.2	-	3	439	c.338G>A	c.(337-339)AGA>AAA	p.R113K	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Missense_Mutation_p.R113K|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Missense_Mutation_p.R193K	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	113	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGCACCTCTCTGCAGCGCCA	0.731000												
CYP2S1	29785	broad.mit.edu	37	19	41704707	41704707	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:41704707C>T	uc002opw.2	+	5	803	c.748C>T	c.(748-750)CGG>TGG	p.R250W	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Intron	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	250					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						CTTCACAGTCCGGCAGGTGCA	0.642000												
SPHK2	56848	broad.mit.edu	37	19	49132886	49132886	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:49132886C>T	uc002pjr.2	+	7	2187	c.1821C>T	c.(1819-1821)GCC>GCT	p.A607A	SPHK2_uc010xzt.1_Silent_p.A548A|SPHK2_uc002pjs.2_Silent_p.A607A|SPHK2_uc002pjt.2_Silent_p.A401A|SPHK2_uc002pju.2_Intron|SPHK2_uc002pjv.2_Silent_p.A571A|SPHK2_uc002pjw.2_Silent_p.A669A	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	607					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CGGCCCGTGCCTTCCGCCTAG	0.677000												
ZNF677	342926	broad.mit.edu	37	19	53741803	53741803	+	Silent	SNP	A	A	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:53741803A>G	uc002qbf.1	-	5	362	c.177T>C	c.(175-177)TCT>TCC	p.S59S	ZNF677_uc002qbg.1_Silent_p.S59S	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		TAAATCCAACAGAAATATCTG	0.299000												
PRKCG	5582	broad.mit.edu	37	19	54401213	54401213	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:54401213C>T	uc002qcq.1	+	10	1222	c.940C>T	c.(940-942)CGG>TGG	p.R314W	PRKCG_uc010yef.1_Silent_p.S284S|PRKCG_uc010yeg.1_Missense_Mutation_p.R314W|PRKCG_uc010yeh.1_Missense_Mutation_p.R201W	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	314				RVRM -> VSRT (in Ref. 3; AAA60102).	activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CTTTCCACAGCGGGTGCGGAT	0.473000												
PRPF31	26121	broad.mit.edu	37	19	54621676	54621676	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:54621676G>A	uc002qdh.2	+	2	414	c.18G>A	c.(16-18)GAG>GAA	p.E6E	TFPT_uc010yej.1_5'Flank|TFPT_uc010erd.2_5'Flank|PRPF31_uc010yek.1_Silent_p.E6E	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	6					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGGCAGATGAGCTCTTAGCTG	0.323000												
CNOT3	4849	broad.mit.edu	37	19	54657452	54657452	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:54657452G>T	uc002qdj.1	+	17	2349	c.2038G>T	c.(2038-2040)GGC>TGC	p.G680C	CNOT3_uc010yel.1_Missense_Mutation_p.R707S|CNOT3_uc002qdi.2_Missense_Mutation_p.R591S|CNOT3_uc002qdk.1_Missense_Mutation_p.G680C|CNOT3_uc010ere.1_RNA|CNOT3_uc002qdl.2_Missense_Mutation_p.G135C	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	680					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCTCCCCCAGGGCACTAAGGC	0.627000												
LILRB2	10288	broad.mit.edu	37	19	54778550	54778550	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:54778550A>G	uc002qfb.2	-	14	2050	c.1784T>C	c.(1783-1785)CTG>CCG	p.L595P	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_3'UTR|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.L594P|LILRB2_uc010yet.1_Missense_Mutation_p.L479P	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	595	ITIM motif 3.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTGGATGGCCAGGGTGGCGTA	0.612000												
KIR3DL1	3811	broad.mit.edu	37	19	55329954	55329954	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:55329954G>A	uc002qhk.3	+	3	318	c.255G>A	c.(253-255)GTG>GTA	p.V85V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Silent_p.V27V|KIR3DL1_uc010esf.2_Intron|KIR3DL1_uc010yfo.1_Silent_p.V27V|KIR3DL1_uc002qhl.3_Silent_p.V85V	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	85	Extracellular (Potential).|Ig-like C2-type 1.				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		TGAGCCCTGTGACCACAGCAC	0.512000												
AURKC	6795	broad.mit.edu	37	19	57746683	57746683	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:57746683C>A	uc002qoe.2	+	7	1017	c.828C>A	c.(826-828)TAC>TAA	p.Y276*	AURKC_uc002qoc.2_Nonsense_Mutation_p.Y257*|AURKC_uc002qod.2_Nonsense_Mutation_p.Y242*|AURKC_uc010etv.2_Nonsense_Mutation_p.Y273*	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	276	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		TTCTCAGATACCAGCCCTTGG	0.577000												
ZSCAN18	65982	broad.mit.edu	37	19	58601477	58601477	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:58601477C>T	uc002qri.2	-	2	467	c.158G>A	c.(157-159)CGG>CAG	p.R53Q	ZSCAN18_uc002qrj.3_Missense_Mutation_p.R53Q|ZSCAN18_uc010yhs.1_Intron|ZSCAN18_uc002qrh.2_Missense_Mutation_p.R53Q|ZSCAN18_uc010yht.1_Missense_Mutation_p.R109Q|ZSCAN18_uc002qrk.1_Missense_Mutation_p.R53Q|ZSCAN18_uc002qrl.2_Missense_Mutation_p.R53Q	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	53	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GACAAATTCCCGGAAACGCAG	0.677000												
CPSF3	51692	broad.mit.edu	37	2	9580739	9580739	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:9580739C>T	uc002qzo.1	+	8	915	c.880C>T	c.(880-882)CGC>TGC	p.R294C	CPSF3_uc010ewx.1_Missense_Mutation_p.R294C|CPSF3_uc002qzp.1_Missense_Mutation_p.R257C	NM_016207	NP_057291	Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3,	294					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			breast(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		TGACAAAATCCGCAAACAGAT	0.383000												
CLIP4	79745	broad.mit.edu	37	2	29383251	29383251	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:29383251A>T	uc002rmv.2	+	12	1691	c.1452A>T	c.(1450-1452)GAA>GAT	p.E484D	CLIP4_uc002rmu.2_Missense_Mutation_p.E484D|CLIP4_uc010ezm.1_Missense_Mutation_p.E484D|CLIP4_uc002rmw.2_RNA	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	484										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GCGAGGGGGAACTCCGCCTCG	0.498000												
MAL	4118	broad.mit.edu	37	2	95713846	95713846	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:95713846G>T	uc002stx.1	+	2	295	c.236G>T	c.(235-237)GGT>GTT	p.G79V	MAL_uc002sty.1_Intron|MAL_uc002stz.1_Missense_Mutation_p.G79V|MAL_uc002sua.1_Intron	NM_002371	NP_002362	P21145	MAL_HUMAN	T-lymphocyte maturation-associated protein	79	Cytoplasmic (Potential).|MARVEL.				apical protein localization|cell differentiation|central nervous system development|induction of apoptosis|membrane raft polarization|myelination	apical plasma membrane|endoplasmic reticulum|endosome|integral to plasma membrane|membrane raft	apoptotic protease activator activity|channel activity|lipid binding|structural constituent of myelin sheath				0				STAD - Stomach adenocarcinoma(1183;0.18)		GGAGCCCACGGTGGAGAGACT	0.617000												
ZNF2	7549	broad.mit.edu	37	2	95847608	95847608	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:95847608C>T	uc002suf.2	+	6	1494	c.1032C>T	c.(1030-1032)AAC>AAT	p.N344N	ZNF2_uc002sug.2_Silent_p.N302N|ZNF2_uc010yue.1_Silent_p.N307N|ZNF2_uc010fhs.2_Silent_p.N265N	NM_021088	NP_066574	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2 isoform a	344	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		ATCAGTGTAACGAGTGTGGCA	0.493000												
MBD5	55777	broad.mit.edu	37	2	149240903	149240903	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:149240903A>T	uc002twm.3	+	10	3731	c.2743A>T	c.(2743-2745)AAC>TAC	p.N915Y	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.N915Y|MBD5_uc002two.2_5'Flank|MBD5_uc002twp.2_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	915						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ACACCCCTTGAACCCCAGCCT	0.468000												
SCN1A	6323	broad.mit.edu	37	2	166848344	166848344	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:166848344T>G	uc010zcz.1	-	26	5426	c.5408A>C	c.(5407-5409)AAG>ACG	p.K1803T		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1814	IV.		WEKF -> C (in SMEI).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGGATCAAACTTCTCCCAAAC	0.453000												
HOXD4	3233	broad.mit.edu	37	2	177017437	177017437	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:177017437C>G	uc002uks.2	+	2	784	c.535C>G	c.(535-537)CTG>GTG	p.L179V		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	179	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		TAACAGGTATCTGACAAGGCG	0.527000												
CASP8	841	broad.mit.edu	37	2	202151266	202151266	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:202151266G>C	uc002uxr.1	+	10	1598	c.1389G>C	c.(1387-1389)ATG>ATC	p.M463I	CASP8_uc002uxp.1_Missense_Mutation_p.M480I|CASP8_uc002uxq.1_Missense_Mutation_p.M448I|CASP8_uc002uxt.1_Missense_Mutation_p.M522I|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Missense_Mutation_p.M448I|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Missense_Mutation_p.M379I	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	463					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GGAAACAGATGCCTCAGCCTA	0.318000										HNSCC(4;0.00038)		
COL6A3	1293	broad.mit.edu	37	2	238249128	238249128	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr2:238249128G>A	uc002vwl.2	-	38	8716	c.8431C>T	c.(8431-8433)CGC>TGC	p.R2811C	COL6A3_uc002vwo.2_Missense_Mutation_p.R2605C|COL6A3_uc010znj.1_Missense_Mutation_p.R2204C|COL6A3_uc002vwj.2_Missense_Mutation_p.R192C	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2811	VWFA 12.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTCCCGAAGCGCATCAAAGGC	0.552000												
INSM1	3642	broad.mit.edu	37	20	20350144	20350144	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr20:20350144C>T	uc002wrx.2	+	1	1380	c.1233C>T	c.(1231-1233)TAC>TAT	p.Y411Y		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	411					endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		TGGCCTTGTACCCCGGGCCCG	0.761000												
GGTLC1	92086	broad.mit.edu	37	20	23967200	23967200	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr20:23967200C>T	uc002wts.2	-	2	182	c.49G>A	c.(49-51)GAC>AAC	p.D17N	GGTLC1_uc002wtu.2_Missense_Mutation_p.D17N	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1	17							gamma-glutamyltransferase activity			ovary(1)	1						TGAGTGGTGTCGTCAGAGATC	0.637000												
EPB41L1	2036	broad.mit.edu	37	20	34775685	34775685	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr20:34775685G>C	uc002xfb.2	+	8	1044	c.873G>C	c.(871-873)AAG>AAC	p.K291N	EPB41L1_uc002xeu.2_Missense_Mutation_p.K229N|EPB41L1_uc010zvo.1_Missense_Mutation_p.K291N|EPB41L1_uc002xev.2_Missense_Mutation_p.K291N|EPB41L1_uc002xew.2_Missense_Mutation_p.K194N|EPB41L1_uc002xex.2_Missense_Mutation_p.K260N|EPB41L1_uc002xey.2_Missense_Mutation_p.K218N|EPB41L1_uc002xez.2_Missense_Mutation_p.K229N	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	291	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					ACCATGCCAAGGTACCACCAG	0.537000												
PCIF1	63935	broad.mit.edu	37	20	44574499	44574499	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr20:44574499A>T	uc002xqs.2	+	12	1632	c.1318A>T	c.(1318-1320)AGC>TGC	p.S440C	PCIF1_uc002xqt.2_Missense_Mutation_p.S20C|PCIF1_uc002xqu.2_5'Flank	NM_022104	NP_071387	Q9H4Z3	PCIF1_HUMAN	phosphorylated CTD interacting factor 1	440						nucleus				skin(1)	1						GGTCAAGGTCAGCCGCAACTA	0.587000												
SLCO4A1	28231	broad.mit.edu	37	20	61287965	61287965	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr20:61287965C>T	uc002ydb.1	+	2	364	c.159C>T	c.(157-159)GAC>GAT	p.D53D	SLCO4A1_uc002ydc.1_RNA	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	53	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			GCCCCCTGGACACCAGCAAGC	0.716000												
DIDO1	11083	broad.mit.edu	37	20	61542173	61542173	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr20:61542173G>A	uc002ydr.1	-	3	1056	c.792C>T	c.(790-792)TAC>TAT	p.Y264Y	DIDO1_uc002yds.1_Silent_p.Y264Y|DIDO1_uc002ydt.1_Silent_p.Y264Y|DIDO1_uc002ydu.1_Silent_p.Y264Y|DIDO1_uc002ydv.1_Silent_p.Y264Y|DIDO1_uc002ydw.1_Silent_p.Y264Y|DIDO1_uc002ydx.1_Silent_p.Y264Y|DIDO1_uc011aao.1_Silent_p.Y264Y	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	264					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CGTTGGGGTCGTAACCCTCAC	0.537000												
ARVCF	421	broad.mit.edu	37	22	19967604	19967604	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr22:19967604G>A	uc002zqz.2	-	6	1329	c.1058C>T	c.(1057-1059)CCG>CTG	p.P353L	ARVCF_uc002zqy.2_5'Flank|ARVCF_uc002zra.2_3'UTR	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	353	ARM 1.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					CCGCCAGCGCGGCTCCTTGCG	0.721000												
EFCAB6	64800	broad.mit.edu	37	22	43933323	43933323	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr22:43933323G>T	uc003bdy.1	-	29	4197	c.3982C>A	c.(3982-3984)CTC>ATC	p.L1328I	EFCAB6_uc003bdz.1_Missense_Mutation_p.L1176I|EFCAB6_uc010gzi.1_Missense_Mutation_p.L1176I	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1328	Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				TCTTTCAGGAGCTGGCGCCAG	0.567000												
GNL3	26354	broad.mit.edu	37	3	52725622	52725622	+	Silent	SNP	T	T	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr3:52725622T>G	uc003dfd.2	+	9	1019	c.846T>G	c.(844-846)GTT>GTG	p.V282V	GNL3_uc003dfe.2_Silent_p.V270V|GNL3_uc003dff.2_Silent_p.V270V|SNORD69_uc003dfh.1_5'Flank	NM_014366	NP_055181	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3	282	G.|Intermediate (By similarity).				regulation of cell proliferation	nucleolus	GTP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		TGTGTAATGTTGGTGTATCCA	0.338000												
CEP63	80254	broad.mit.edu	37	3	134276999	134276999	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr3:134276999C>G	uc003eqo.1	+	14	1932	c.1483C>G	c.(1483-1485)CTA>GTA	p.L495V	CEP63_uc003eql.1_Intron|CEP63_uc003eqm.2_Intron|CEP63_uc003eqn.1_Intron	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	495	Potential.				cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						AGAGATTTCACTAGCAGACCT	0.338000												
KIAA1109	84162	broad.mit.edu	37	4	123161241	123161241	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr4:123161241G>A	uc003ieh.2	+	27	4449	c.4404G>A	c.(4402-4404)GCG>GCA	p.A1468A	KIAA1109_uc003iei.1_Silent_p.A1221A|KIAA1109_uc010ins.1_Silent_p.A811A|KIAA1109_uc003iek.2_Silent_p.A87A	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1468					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTGTTTCTGCGTTAGGTGGAG	0.418000												
PCDH10	57575	broad.mit.edu	37	4	134072398	134072398	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr4:134072398G>T	uc003iha.2	+	1	1929	c.1103G>T	c.(1102-1104)AGT>ATT	p.S368I	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.S368I	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	368	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GAAGCGGTGAGTGAGGGCGCG	0.627000												
INPP4B	8821	broad.mit.edu	37	4	143007328	143007328	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr4:143007328T>A	uc003iix.3	-	25	3051	c.2456A>T	c.(2455-2457)AAG>ATG	p.K819M	INPP4B_uc003iiw.3_Missense_Mutation_p.K819M|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.K634M|INPP4B_uc011cho.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	819					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TTCTACATTCTTTCTTTTTTT	0.333000												
FGG	2266	broad.mit.edu	37	4	155533323	155533323	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr4:155533323C>T	uc003ioj.2	-	3	295	c.154G>A	c.(154-156)GCA>ACA	p.A52T	FGG_uc003iog.2_Missense_Mutation_p.A52T|FGG_uc003ioh.2_Missense_Mutation_p.A52T|FGG_uc010ipx.2_5'UTR|FGG_uc010ipy.2_Intron|FGG_uc003ioi.2_5'Flank|FGG_uc003iok.2_Missense_Mutation_p.A52T	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	52					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AGGAAATCTGCAATGCCACAG	0.328000												
CDH9	1007	broad.mit.edu	37	5	26988325	26988325	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr5:26988325C>A	uc003jgs.1	-	2	285	c.116G>T	c.(115-117)GGT>GTT	p.G39V	CDH9_uc010iug.2_Missense_Mutation_p.G39V	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	39					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTTTGTCAGACCCGCTATCTT	0.393000												
NUP155	9631	broad.mit.edu	37	5	37333694	37333694	+	Silent	SNP	C	C	T	rs142662644	byFrequency	TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr5:37333694C>T	uc003jku.1	-	13	1507	c.1389G>A	c.(1387-1389)GCG>GCA	p.A463A	NUP155_uc003jkt.1_Silent_p.A404A|NUP155_uc010iuz.1_Silent_p.A463A	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	463					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATTCATCTATCGCAGAAAGAG	0.328000												
OXCT1	5019	broad.mit.edu	37	5	41862794	41862794	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr5:41862794G>A	uc003jmn.2	-	2	468	c.137C>T	c.(136-138)CCA>CTA	p.P46L		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor	46					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	AGCTTCTACTGGATCTGTATA	0.358000												
PCDHA10	56139	broad.mit.edu	37	5	140237313	140237313	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr5:140237313C>T	uc003lhx.2	+	1	1680	c.1680C>T	c.(1678-1680)AAC>AAT	p.N560N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Silent_p.N560N	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	560	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAACGACAACGCTCCCGCGC	0.682000												
PCDHB2	56133	broad.mit.edu	37	5	140474846	140474846	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr5:140474846C>T	uc003lil.2	+	1	610	c.472C>T	c.(472-474)CGT>TGT	p.R158C	PCDHB2_uc003lim.1_Translation_Start_Site	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	158	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTAATAGAACGTGCCCAGGA	0.383000												
PRSS16	10279	broad.mit.edu	37	6	27215755	27215755	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr6:27215755C>T	uc003nja.2	+	2	177	c.165C>T	c.(163-165)GCC>GCT	p.A55A	PRSS16_uc011dkt.1_RNA|PRSS16_uc003njb.2_Silent_p.A55A|PRSS16_uc010jqq.1_5'Flank|PRSS16_uc010jqr.1_5'Flank|PRSS16_uc003njc.1_5'Flank	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	55					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						GTGCTGCAGCCCTCCCAAAAG	0.637000												
OR2B3	442184	broad.mit.edu	37	6	29054811	29054811	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr6:29054811C>T	uc003nlx.2	-	1	280	c.215G>A	c.(214-216)TGC>TAC	p.C72Y		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						TGTGGTATAGCAGAGATCTAA	0.423000												
LRFN2	57497	broad.mit.edu	37	6	40359728	40359728	+	Missense_Mutation	SNP	C	C	T	rs146316351	byFrequency	TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr6:40359728C>T	uc003oph.1	-	3	2789	c.2324G>A	c.(2323-2325)CGG>CAG	p.R775Q		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	775	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AAAAGTCCCCCGGGCCCCCAC	0.607000												
MRPS10	55173	broad.mit.edu	37	6	42185576	42185576	+	Silent	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr6:42185576C>T	uc003osa.3	-	1	58	c.12G>A	c.(10-12)CGG>CGA	p.R4R	MRPS10_uc011dup.1_5'UTR	NM_018141	NP_060611	P82664	RT10_HUMAN	mitochondrial ribosomal protein S10	4					translation	actin cytoskeleton|mitochondrion|ribosome	structural constituent of ribosome				0	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00528)			CGAACGCTGTCCGCGCCGCCA	0.592000												
EYS	346007	broad.mit.edu	37	6	66204885	66204885	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr6:66204885C>A	uc011dxu.1	-	4	957	c.419G>T	c.(418-420)TGG>TTG	p.W140L	EYS_uc003peq.2_Missense_Mutation_p.W140L|EYS_uc003per.1_Missense_Mutation_p.W140L|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	140					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						AACACTCAGCCACTTAGAATT	0.423000												
RIMS1	22999	broad.mit.edu	37	6	72984077	72984077	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr6:72984077A>T	uc003pga.2	+	23	3501	c.3424A>T	c.(3424-3426)AGG>TGG	p.R1142W	RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Intron|RIMS1_uc010kaq.2_Intron|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgf.2_Intron|RIMS1_uc003pgg.2_Missense_Mutation_p.R295W|RIMS1_uc003pgi.2_Intron|RIMS1_uc003pgh.2_Intron|RIMS1_uc003pgd.2_Intron|RIMS1_uc003pge.2_Intron|RIMS1_uc011dye.1_Intron|RIMS1_uc011dyf.1_Intron	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1142					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CTCCCTAGATAGGAGACGACC	0.463000												
OPRM1	4988	broad.mit.edu	37	6	154439830	154439830	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr6:154439830G>T	uc003qpr.2	+	4	1414	c.1177G>T	c.(1177-1179)GAA>TAA	p.E393*	OPRM1_uc011efc.1_Nonsense_Mutation_p.E312*|OPRM1_uc011efd.1_Nonsense_Mutation_p.E293*|OPRM1_uc011efe.1_Nonsense_Mutation_p.E486*|OPRM1_uc003qpt.1_Intron|OPRM1_uc003qps.2_RNA|OPRM1_uc010kjg.2_Nonsense_Mutation_p.E293*	NM_000914	NP_000905	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1	393	Cytoplasmic (Potential).				behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	AGAAAATCTGGAAGCAGAAAC	0.458000												
NUPL2	11097	broad.mit.edu	37	7	23221774	23221774	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:23221774G>C	uc003svu.2	+	1	329	c.70G>C	c.(70-72)GGT>CGT	p.G24R	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_5'UTR|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_5'UTR	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	24	C3H1-type.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						CGAACATCCCGGTGCTAGGGG	0.627000												
OSBPL3	26031	broad.mit.edu	37	7	24905023	24905023	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:24905023C>T	uc003sxf.2	-	7	1016	c.611G>A	c.(610-612)GGT>GAT	p.G204D	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.G204D|OSBPL3_uc003sxh.2_Missense_Mutation_p.G204D|OSBPL3_uc003sxi.2_Missense_Mutation_p.G204D	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	204					lipid transport		lipid binding|protein binding			skin(1)	1						TGTCTCACCACCACAAGAAAA	0.403000												
POM121L12	285877	broad.mit.edu	37	7	53103907	53103907	+	Silent	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:53103907G>A	uc003tpz.2	+	1	559	c.543G>A	c.(541-543)GCG>GCA	p.A181A		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	181											0						TGCTGGGGGCGCTCAGCCAGT	0.582000												
POM121	9883	broad.mit.edu	37	7	72399003	72399003	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:72399003A>T	uc003twk.2	+	4	1103	c.1103A>T	c.(1102-1104)AAG>ATG	p.K368M	POM121_uc003twj.2_Missense_Mutation_p.K103M|POM121_uc010lam.1_Missense_Mutation_p.K103M	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	368	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				TTTGTGCCTAAGTAAGTGGGA	0.468000												
CDK14	5218	broad.mit.edu	37	7	90419944	90419944	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:90419944C>T	uc003uky.2	+	5	743	c.521C>T	c.(520-522)ACA>ATA	p.T174I	CDK14_uc003ukt.1_Missense_Mutation_p.T128I|CDK14_uc003ukv.1_Missense_Mutation_p.T128I|CDK14_uc003uku.1_Missense_Mutation_p.T128I|CDK14_uc003ukx.1_RNA|CDK14_uc003ukz.1_Missense_Mutation_p.T156I|CDK14_uc010les.1_Missense_Mutation_p.T128I|CDK14_uc011khl.1_Missense_Mutation_p.T45I	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	174	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						GAAGAAGGGACACCTTTCACA	0.408000												
FZD1	8321	broad.mit.edu	37	7	90896065	90896065	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:90896065G>A	uc003ula.2	+	1	2283	c.1870G>A	c.(1870-1872)GGC>AGC	p.G624S		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	624	Cytoplasmic (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			GATCTGGTCCGGCAAGACCCT	0.597000												
FLNC	2318	broad.mit.edu	37	7	128487899	128487899	+	Silent	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:128487899G>C	uc003vnz.3	+	25	4646	c.4437G>C	c.(4435-4437)GTG>GTC	p.V1479V	FLNC_uc003voa.3_Silent_p.V1479V	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1479	Filamin 13.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CCCTGCAGGTGGCTGTGCTGG	0.697000												
KRBA1	84626	broad.mit.edu	37	7	149430833	149430833	+	Silent	SNP	T	T	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:149430833T>A	uc003wfz.2	+	18	3189	c.2790T>A	c.(2788-2790)TCT>TCA	p.S930S	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.S537S	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	930	Pro-rich.									ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACTGCAGCTCTTCCCAGCAGC	0.692000												
GIMAP1	170575	broad.mit.edu	37	7	150417616	150417616	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:150417616G>A	uc003whq.2	+	3	611	c.524G>A	c.(523-525)CGC>CAC	p.R175H	GIMAP1_uc003whp.2_Missense_Mutation_p.R183H	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	175	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CGGGCCTTGCGCGAGCTGGTG	0.652000												
ST18	9705	broad.mit.edu	37	8	53073962	53073962	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr8:53073962C>T	uc003xqz.2	-	9	1723	c.1567G>A	c.(1567-1569)GGA>AGA	p.G523R	ST18_uc011ldq.1_Missense_Mutation_p.G170R|ST18_uc011ldr.1_Missense_Mutation_p.G488R|ST18_uc011lds.1_Missense_Mutation_p.G428R|ST18_uc003xra.2_Missense_Mutation_p.G523R|ST18_uc003xrb.2_Missense_Mutation_p.G523R	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	523						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GTTTTTCGTCCTTGCACTGTT	0.428000												
C8orf34	116328	broad.mit.edu	37	8	69434170	69434170	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr8:69434170G>A	uc010lyz.2	+	6	693	c.644G>A	c.(643-645)TGG>TAG	p.W215*	C8orf34_uc010lyy.1_Nonsense_Mutation_p.W215*|C8orf34_uc003xyb.2_Nonsense_Mutation_p.W190*	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	215					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			AATGACCAATGGGAAAGTGAA	0.418000												
ZNF704	619279	broad.mit.edu	37	8	81605248	81605248	+	Missense_Mutation	SNP	G	G	A	rs148333158		TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr8:81605248G>A	uc003yby.1	-	3	548	c.316C>T	c.(316-318)CGG>TGG	p.R106W		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	106						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			CCGTTCGGCCGCACGGGAGGA	0.522000												
ZFPM2	23414	broad.mit.edu	37	8	106814853	106814853	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr8:106814853A>G	uc003ymd.2	+	8	2566	c.2543A>G	c.(2542-2544)AAA>AGA	p.K848R	ZFPM2_uc011lhs.1_Missense_Mutation_p.K579R	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	848					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ACGTCTCCCAAAAGGCTGCTG	0.478000												
PKHD1L1	93035	broad.mit.edu	37	8	110455187	110455187	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr8:110455187A>T	uc003yne.2	+	36	4510	c.4406A>T	c.(4405-4407)TAC>TTC	p.Y1469F		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1469	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCATTTTCTTACCAATTTACT	0.323000										HNSCC(38;0.096)		
PARP10	84875	broad.mit.edu	37	8	145059422	145059422	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr8:145059422G>C	uc003zal.3	-	5	856	c.748C>G	c.(748-750)CTG>GTG	p.L250V	PARP10_uc003zak.3_5'UTR|PARP10_uc011lku.1_Missense_Mutation_p.L262V|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.L250V|PARP10_uc010mfn.1_Missense_Mutation_p.L165V|PARP10_uc010mfo.1_3'UTR	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	250						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCGGGCTCCAGgatgtcgtag	0.333000												
CNTLN	54875	broad.mit.edu	37	9	17484457	17484457	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr9:17484457A>G	uc003zmz.2	+	24	4043	c.4017A>G	c.(4015-4017)ATA>ATG	p.I1339M	CNTLN_uc003zmy.2_Missense_Mutation_p.I1340M|CNTLN_uc010mio.2_Missense_Mutation_p.I1019M	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1340						centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		TAGAGGAAATATTAGACACAG	0.333000												
GOLGA1	2800	broad.mit.edu	37	9	127643517	127643517	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr9:127643517G>C	uc004bpc.2	-	22	2498	c.2156C>G	c.(2155-2157)GCT>GGT	p.A719G	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	719	GRIP.					Golgi cisterna membrane				ovary(1)	1						CACTGACACAGCTTTTATAAG	0.493000												
SCAI	286205	broad.mit.edu	37	9	127734104	127734104	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr9:127734104G>C	uc004bpe.2	-	16	1500	c.1419C>G	c.(1417-1419)AGC>AGG	p.S473R	SCAI_uc004bpd.2_Missense_Mutation_p.S496R|SCAI_uc010mwu.2_Intron	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	473	Helical; (Potential).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						GAGTGAAGAGGCTACCTCGCT	0.358000												
CHIC1	53344	broad.mit.edu	37	X	72783280	72783282	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chrX:72783280_72783282delGAG	uc004ebk.3	+	1	297_299	c.160_162delGAG	c.(160-162)GAGdel	p.E68del	CHIC1_uc010nlo.2_RNA|CHIC1_uc011mql.1_In_Frame_Del_p.E68del|CHIC1_uc004ebl.3_In_Frame_Del_p.E68del	NM_001039840	NP_001034929	Q5VXU3	CHIC1_HUMAN	cysteine-rich hydrophobic domain 1	68	Poly-Glu.|Potential.					cytoplasmic membrane-bounded vesicle|plasma membrane					0	Renal(35;0.156)					agaggaggaagaggaggaggagg	0.320												
OBSCN	84033	broad.mit.edu	37	1	228430943	228430944	+	Frame_Shift_Ins	INS	-	-	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr1:228430942_228430943A>AG	uc009xez.1	+	9	3032_3033	c.2988_2989A>AG	c.(2986-2991)gcagggfs	p.A996fs	OBSCN_uc001hsn.3_Frame_Shift_Ins_p.A996fs	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	996	Ig-like 10.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	M band|Z disc|cytosol	ATP binding|Rho guanyl-nucleotide exchange factor activity|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGCTGAGGCAGGGGCCAGTGC	0.589												
VARS	7407	broad.mit.edu	37	6	31760235	31760246	+	In_Frame_Del	DEL	TTTCTTTGCCTC	TTTCTTTGCCTC	-			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr6:31760234_31760245GTTTCTTTGCCTC>G	uc003nxe.3	-	4	1133_1144	c.710_721GAGGCAAAGAAAC>C	c.(709-723)gaggcaaagaaacgg>gCgg	p.237_241EAKKR>A	VARS_uc011doi.1_Non-coding_Transcript	NM_006295	NP_006286	P26640	SYVC_HUMAN	Homo sapiens valyl-tRNA synthetase (VARS), nuclear gene encoding mitochondrial protein, mRNA.	237					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	AGCTTCTCCCGTTTCTTTGCCTCTTTCTTGAG	0.561												
TES	26136	broad.mit.edu	37	7	115889259	115889273	+	In_Frame_Del	DEL	CCAAGAAGAATGTCT	CCAAGAAGAATGTCT	-	rs62621959		TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr7:115889258_115889272GCCAAGAAGAATGTCT>G	uc003vho.3	+	2	513_527	c.298_312GCCAAGAAGAATGTCT>G	c.(298-312)gccaagaagaatgtc>G	p.AKKNV100del	TES_uc011kmx.2_In_Frame_Del_p.AKKNV100del|TES_uc011kmy.2_Intron|TES_uc010lka.2_In_Frame_Del_p.AKKNV91del|TES_uc003vhp.3_In_Frame_Del_p.AKKNV91del|TES_uc022aki.1_Non-coding_Transcript	NM_015641	NP_690042	Q9UGI8	TES_HUMAN	Homo sapiens testis derived transcript (3 LIM domains) (TES), transcript variant 1, mRNA.	100	PET.				negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding			endometrium(4)|large_intestine(4)|lung(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	12	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			TCCAGTTGCTGCCAAGAAGAATGTCTCCATCAATA	0.391												
OR52J3	119679	broad.mit.edu	37	11	5068474	5068484	+	Frame_Shift_Del	DEL	GCACGTGTGGC	GCACGTGTGGC	-	rs61731854	byFrequency	TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr11:5068473_5068483AGCACGTGTGGC>A	uc010qyv.2	+	0	718_728	c.718_728AGCACGTGTGGC>A	c.(718-729)agcacgtgtggcfs	p.S240fs		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	Homo sapiens olfactory receptor, family 52, subfamily J, member 3 (OR52J3), mRNA.	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T241T(2)		NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAAAGCCCTAAGCACGTGTGGCGCTCATGTT	0.445												
NBEA	26960	broad.mit.edu	37	13	35731227	35731230	+	Frame_Shift_Del	DEL	GTGT	GTGT	-			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr13:35731226_35731229AGTGT>A	uc021rid.1	+	20	3197_3200	c.2663_2666AGTGT>A	c.(2662-2667)cagtgtfs	p.Q888fs	NBEA_uc021ric.1_Frame_Shift_Del_p.Q888fs	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	Homo sapiens neurobeachin (NBEA), transcript variant 1, mRNA.	888						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGCTTATTGCAGTGTTCAGTGTGG	0.304												
B2M	567	broad.mit.edu	37	15	45007747	45007751	+	Frame_Shift_Del	DEL	GAATT	GAATT	-			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr15:45007746_45007750AGAATT>A	uc001zuc.3	+	1	253_257	c.193_197AGAATT>A	c.(193-198)agaattfs	p.R65fs	B2M_uc010uek.1_Frame_Shift_Del_p.R65fs|B2M_uc010bdx.1_Frame_Shift_Del_p.R65fs	NM_004048	NP_004039	P61769	B2MG_HUMAN	Homo sapiens beta-2-microglobulin (B2M), mRNA.	65	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	Golgi membrane|MHC class I protein complex|early endosome membrane	protein binding	p.K61_L74del(2)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GAATGGAGAGAGAATTGAAAAAGTG	0.415												
CENPN	55839	broad.mit.edu	37	16	81061838	81061838	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr16:81061837_81061837TC>T	uc002ffy.4	+	9	1662	c.872_872TC>T	c.(871-873)ctcfs	p.L291fs	CENPN_uc002ffx.2_Frame_Shift_Del_p.L291fs|CENPN_uc010vnl.1_Frame_Shift_Del_p.L257fs|CENPN_uc010vnm.1_Frame_Shift_Del_p.L271fs	NM_001100625	NP_001094095	Q96H22	CENPN_HUMAN	Homo sapiens centromere protein N (CENPN), transcript variant 1, mRNA.	291					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm				breast(1)|large_intestine(5)|lung(4)	10						GAAGAACCCCTCCGATGCCTA	0.398												
SPACA3	124912	broad.mit.edu	37	17	31323877	31323888	+	In_Frame_Del	DEL	TTTCACAAGCGG	TTTCACAAGCGG	-			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:31323876_31323887ATTTCACAAGCGG>A	uc002hhs.1	+	2	434_445	c.359_370ATTTCACAAGCGG>A	c.(358-372)tatttcacaagcggt>tAgt	p.120_124YFTSG>*	SPACA3_uc010cte.1_Non-coding_Transcript	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	Homo sapiens sperm acrosome associated 3 (SPACA3), mRNA.	120					cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			breast(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	18			BRCA - Breast invasive adenocarcinoma(9;0.193)			TGCCTTGCTTATTTCACAAGCGGTTTCAACGC	0.590												
BZRAP1	9256	broad.mit.edu	37	17	56386384	56386385	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:56386383_56386384C>CT	uc002ivx.4	-	21	5120_5121	c.4249_4250G>AG	c.(4249-4251)agcfs	p.S1417fs	BZRAP1_uc002ivw.3_5'Flank|BZRAP1_uc010dcs.3_Frame_Shift_Ins_p.S1357fs|BZRAP1_uc010wnt.2_Frame_Shift_Ins_p.S1417fs	NM_004758	NP_004749	O95153	RIMB1_HUMAN	Homo sapiens benzodiazapine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant 1, mRNA.	1417						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGCCTGCGGCTTGGGGGCTTC	0.653												
BCAS3	54828	broad.mit.edu	37	17	59112070	59112086	+	Frame_Shift_Del	DEL	GGCGGAGAATTTTGTGT	GGCGGAGAATTTTGTGT	-			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr17:59112069_59112085GGGCGGAGAATTTTGTGT>G	uc002iyv.4	+	17	1834_1850	c.1725_1741GGGCGGAGAATTTTGTGT>G	c.(1723-1743)atgggcggagaattttgtgtgfs	p.M575fs	BCAS3_uc010wow.1_Frame_Shift_Del_p.M347fs|BCAS3_uc002iyu.4_Frame_Shift_Del_p.M560fs|BCAS3_uc002iyw.4_Frame_Shift_Del_p.M556fs|BCAS3_uc002iyy.4_Frame_Shift_Del_p.M331fs|BCAS3_uc002iyz.4_Frame_Shift_Del_p.M129fs|BCAS3_uc002iza.4_Frame_Shift_Del_p.M114fs	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	Homo sapiens breast carcinoma amplified sequence 3 (BCAS3), transcript variant 1, mRNA.	575						nucleus		p.E578*(2)		NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GCAAATCGATGGGCGGAGAATTTTGTGTGGCTGCTAT	0.341												
PRX	57716	broad.mit.edu	37	19	40901644	40901645	+	Frame_Shift_Ins	INS	-	-	G			TCGA-D7-8570-01A-11D-2340-08	TCGA-D7-8570-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	429aad6f-816d-4739-baa3-b0ebf2fcd501	37b5cb53-cfff-47ae-9769-b5df2c72f1e5	g.chr19:40901643_40901644T>TG	uc002onr.3	-	6	2884_2885	c.2615_2616A>CA	c.(2614-2616)ccafs	p.P872fs	PRX_uc002onq.3_Frame_Shift_Ins_p.P733fs|PRX_uc002ons.3_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	Homo sapiens periaxin (PRX), transcript variant 2, mRNA.	872					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTTTAGCGGCTGGGACCTGCCC	0.629