Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PLEKHN1	84069	broad.mit.edu	37	1	909420	909420	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:909420G>A	uc001ace.2	+	13	1833	c.1798G>A	c.(1798-1800)GCC>ACC	p.A600T	PLEKHN1_uc001acd.2_Missense_Mutation_p.A548T|PLEKHN1_uc001acf.2_Missense_Mutation_p.A513T	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	600											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		GCCCCCAGACGCCCCTCAGCT	0.711000												
PHACTR4	65979	broad.mit.edu	37	1	28807116	28807116	+	Missense_Mutation	SNP	G	G	C	rs147207733	by1000genomes	TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:28807116G>C	uc001bpw.2	+	9	2042	c.1760G>C	c.(1759-1761)CGG>CCG	p.R587P	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.R571P|PHACTR4_uc001bpy.2_Missense_Mutation_p.R597P	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	587	RPEL 2.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		ACACTGATCCGGTAGGCCTTT	0.373000												
PTCH2	8643	broad.mit.edu	37	1	45293539	45293539	+	Silent	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:45293539C>A	uc010olf.1	-	14	2046	c.2034G>T	c.(2032-2034)CCG>CCT	p.P678P	PTCH2_uc010olg.1_Silent_p.P376P	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	678	Cytoplasmic (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					GGAGCAGCAACGGGGCAAACT	0.592000									Basal_Cell_Nevus_syndrome			
BEND5	79656	broad.mit.edu	37	1	49201942	49201942	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:49201942G>A	uc001crx.3	-	5	1121	c.1077C>T	c.(1075-1077)CCC>CCT	p.P359P	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron|AGBL4_uc010omx.1_Intron|AGBL4_uc001crv.1_Intron|AGBL4_uc010omy.1_Intron|BEND5_uc001crw.3_Silent_p.P190P	NM_024603	NP_078879	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	359	BEN.									skin(1)	1						GAGGCGAGAGGGGTGGTTTAG	0.458000												
C1orf173	127254	broad.mit.edu	37	1	75037172	75037172	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:75037172A>C	uc001dgg.2	-	14	4441	c.4222T>G	c.(4222-4224)TTA>GTA	p.L1408V		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1408	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTCCGTGCTAATTCCTCTACC	0.547000												
IFI44L	10964	broad.mit.edu	37	1	79093642	79093642	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:79093642T>A	uc010oro.1	+	2	221	c.42T>A	c.(40-42)CAT>CAA	p.H14Q	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	14						cytoplasm					0						ATGAAAATCATCTGCGCAAGC	0.363000												
ZNF644	84146	broad.mit.edu	37	1	91403345	91403345	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:91403345G>A	uc001dnw.2	-	4	3527	c.3385C>T	c.(3385-3387)CGT>TGT	p.R1129C	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	1129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		AGGCCATTACGGTATGCTTCA	0.383000												
GFI1	2672	broad.mit.edu	37	1	92944272	92944272	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:92944272G>A	uc001dou.3	-	6	1127	c.963C>T	c.(961-963)TTC>TTT	p.F321F	GFI1_uc001dov.3_Silent_p.F321F|GFI1_uc001dow.3_Silent_p.F321F	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	321	C2H2-type 3.				negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		ATGACCTCTTGAAGCTCTTCC	0.433000												
PDE4DIP	9659	broad.mit.edu	37	1	145075742	145075742	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:145075742G>A	uc001emh.2	-	1	338	c.121C>T	c.(121-123)CAG>TAG	p.Q41*	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Nonsense_Mutation_p.Q41*|PDE4DIP_uc001emk.2_Nonsense_Mutation_p.Q41*	NM_022359	NP_071754	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	715					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CGTGGGGACTGAGGGGTTCGC	0.736000			T	PDGFRB	MPD							
ANKRD35	148741	broad.mit.edu	37	1	145562224	145562224	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:145562224C>T	uc001eob.1	+	10	2020	c.1912C>T	c.(1912-1914)CGG>TGG	p.R638W	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Missense_Mutation_p.R481W	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	638	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGGGCGGGAGCGGCAGAGGTT	0.607000												
ETV3L	440695	broad.mit.edu	37	1	157062655	157062655	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:157062655C>T	uc001fqq.1	-	5	1157	c.872G>A	c.(871-873)GGG>GAG	p.G291E		NM_001004341	NP_001004341	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	291						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Hepatocellular(266;0.158)	Prostate(1639;0.184)				CTGTCCCAGCCCTGCCAAGAG	0.632000												
KIRREL	55243	broad.mit.edu	37	1	158057640	158057640	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:158057640T>G	uc001frn.3	+	6	1161	c.757T>G	c.(757-759)TTG>GTG	p.L253V	KIRREL_uc010pib.1_Missense_Mutation_p.L153V|KIRREL_uc009wsq.2_Missense_Mutation_p.L89V|KIRREL_uc001fro.3_Missense_Mutation_p.L51V	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	253	Extracellular (Potential).|Ig-like C2-type 3.					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CCCCGAGATCTTGGGCTACAG	0.602000											OREG0013906	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
KDM5B	10765	broad.mit.edu	37	1	202715452	202715452	+	Splice_Site	SNP	C	C	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:202715452C>G	uc001gyf.2	-	15	2133	c.2017_splice	c.e15-1	p.G673_splice	KDM5B_uc009xag.2_Splice_Site_p.G709_splice|KDM5B_uc001gyg.1_Splice_Site_p.G515_splice	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B						negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						CAATCACTCCCTAGAATAAAG	0.378000												
OR2G2	81470	broad.mit.edu	37	1	247752185	247752185	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:247752185G>A	uc010pyy.1	+	1	524	c.524G>A	c.(523-525)CGC>CAC	p.R175H		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGTGGGCATCGCCAAGTGGAT	0.552000												
OR2G3	81469	broad.mit.edu	37	1	247769166	247769166	+	Silent	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:247769166T>C	uc010pyz.1	+	1	279	c.279T>C	c.(277-279)ACT>ACC	p.T93T		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGACGATCACTTACGGTGGTT	0.468000												
OR2M4	26245	broad.mit.edu	37	1	248402821	248402821	+	Silent	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:248402821A>G	uc010pzh.1	+	1	591	c.591A>G	c.(589-591)AGA>AGG	p.R197R		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	197	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CATTTGAAAGACTACTTGTCA	0.413000												
USP6NL	9712	broad.mit.edu	37	10	11523795	11523795	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr10:11523795C>T	uc001ikt.3	-	14	1373	c.1052G>A	c.(1051-1053)CGG>CAG	p.R351Q	USP6NL_uc001iks.1_Missense_Mutation_p.R368Q	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	351						intracellular	Rab GTPase activator activity				0						TAACTTTGCCCGCTTTAGTTC	0.363000												
C1QL3	389941	broad.mit.edu	37	10	16562644	16562644	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr10:16562644C>T	uc001ioj.1	-	1	1361	c.421G>A	c.(421-423)GAG>AAG	p.E141K		NM_001010908	NP_001010908	Q5VWW1	C1QL3_HUMAN	complement component 1, q subcomponent-like 3	141	C1q.					collagen				ovary(1)	1						TTGAGCACCTCGTAGCCTTCA	0.602000												
BICC1	80114	broad.mit.edu	37	10	60560026	60560026	+	Missense_Mutation	SNP	G	G	T	rs34714605		TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr10:60560026G>T	uc001jki.1	+	13	1798	c.1798G>T	c.(1798-1800)GAT>TAT	p.D600Y	BICC1_uc001jkj.1_Missense_Mutation_p.D241Y	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	600					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						AAATCACGGGGATCCGTCCAT	0.403000												
CPN1	1369	broad.mit.edu	37	10	101835745	101835745	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr10:101835745C>T	uc001kql.2	-	2	603	c.343G>A	c.(343-345)GTC>ATC	p.V115I		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	115	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		ATGAGCTGGACGATGCGCTGG	0.617000												
ATRNL1	26033	broad.mit.edu	37	10	117059577	117059577	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr10:117059577A>C	uc001lcg.2	+	16	2835	c.2449A>C	c.(2449-2451)AAT>CAT	p.N817H	ATRNL1_uc010qsm.1_5'UTR|ATRNL1_uc010qsn.1_5'Flank	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	817	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GCGCAAGATCAATATATCCTA	0.408000												
OR51M1	390059	broad.mit.edu	37	11	5411155	5411155	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:5411155A>G	uc010qzc.1	+	1	527	c.527A>G	c.(526-528)AAG>AGG	p.K176R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	176						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCCTCCTGAAGGCTTTTCCC	0.512000												
NELL1	4745	broad.mit.edu	37	11	20959354	20959354	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:20959354A>C	uc001mqe.2	+	10	1173	c.1020A>C	c.(1018-1020)AAA>AAC	p.K340N	NELL1_uc001mqf.2_Missense_Mutation_p.K340N|NELL1_uc009yid.2_Missense_Mutation_p.K368N|NELL1_uc010rdo.1_Missense_Mutation_p.K283N|NELL1_uc010rdp.1_Missense_Mutation_p.K100N	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	340	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ATGGAGGAAAAGTTCTTGCAG	0.403000												
CD44	960	broad.mit.edu	37	11	35232982	35232982	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:35232982A>G	uc001mvu.2	+	14	2230	c.1796A>G	c.(1795-1797)AAT>AGT	p.N599S	CD44_uc001mvv.2_Missense_Mutation_p.N556S|CD44_uc001mvw.2_Missense_Mutation_p.N350S|CD44_uc001mvx.2_Intron|CD44_uc001mvy.2_Intron|CD44_uc001mwc.3_Missense_Mutation_p.N286S|CD44_uc010rer.1_Intron|CD44_uc009ykh.2_Intron|CD44_uc010res.1_Missense_Mutation_p.N163S|CD44_uc010ret.1_RNA|CD44_uc010reu.1_Missense_Mutation_p.N127S	NM_000610	NP_000601	P16070	CD44_HUMAN	CD44 antigen isoform 1 precursor	599	Extracellular (Potential).|Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			pancreas(1)	1	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	TCTAATGTCAATCGTTCCTTA	0.383000												
RAG1	5896	broad.mit.edu	37	11	36594879	36594879	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:36594879T>G	uc001mwu.3	+	2	149	c.25T>G	c.(25-27)TTG>GTG	p.L9V	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	9	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				CCCACCCACCTTGGGACTCAG	0.423000									Familial_Hemophagocytic_Lymphohistiocytosis			
LRRC4C	57689	broad.mit.edu	37	11	40136913	40136913	+	Silent	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:40136913C>A	uc001mxa.1	-	2	2894	c.930G>T	c.(928-930)CTG>CTT	p.L310L	LRRC4C_uc001mxc.1_Silent_p.L306L|LRRC4C_uc001mxd.1_Silent_p.L306L|LRRC4C_uc001mxb.1_Silent_p.L306L	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	310	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				AGCTGAGCCACAGTATGTCAC	0.478000												
CHST1	8534	broad.mit.edu	37	11	45671646	45671646	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:45671646G>A	uc001mys.1	-	4	1499	c.828C>T	c.(826-828)TGC>TGT	p.C276C		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	276	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		AGAAGTCCTCGCACACCGTGG	0.647000												
OR4A47	403253	broad.mit.edu	37	11	48510689	48510689	+	Silent	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:48510689G>T	uc010rhx.1	+	1	345	c.345G>T	c.(343-345)GTG>GTT	p.V115V		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCCTGTTGGTGATGGCCTATG	0.473000												
OR8H3	390152	broad.mit.edu	37	11	55890635	55890635	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:55890635A>G	uc001nii.1	+	1	787	c.787A>G	c.(787-789)AGA>GGA	p.R263G		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					CTTAAAGCCAAGAAAGTCTTA	0.388000												
OR9Q2	219957	broad.mit.edu	37	11	57958763	57958763	+	Silent	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:57958763C>A	uc010rka.1	+	1	801	c.801C>A	c.(799-801)TCC>TCA	p.S267S		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				CAGGCCAGTCCTCCGAGGGAG	0.562000												
TYR	7299	broad.mit.edu	37	11	88961116	88961116	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:88961116C>A	uc001pcs.2	+	3	1244	c.1162C>A	c.(1162-1164)CTT>ATT	p.L388I		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	388	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TATCTTCCTTCTTCACCATGC	0.398000									Oculocutaneous_Albinism			
FAM76B	143684	broad.mit.edu	37	11	95509183	95509183	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:95509183G>A	uc001pfn.2	-	9	1145	c.833C>T	c.(832-834)ACT>ATT	p.T278I	FAM76B_uc001pfm.2_RNA	NM_144664	NP_653265	Q5HYJ3	FA76B_HUMAN	hypothetical protein LOC143684	278	Potential.										0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CTTTAGTTCAGTTAACTGAGA	0.313000												
DRD2	1813	broad.mit.edu	37	11	113295233	113295233	+	Silent	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:113295233G>T	uc001pnz.2	-	1	462	c.141C>A	c.(139-141)GTC>GTA	p.V47V	DRD2_uc010rwv.1_Silent_p.V47V|DRD2_uc001poa.3_Silent_p.V47V|DRD2_uc001pob.3_Silent_p.V47V|DRD2_uc009yyr.1_Silent_p.V47V	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	47	Helical; Name=1; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CGAAGACGATGACAGCGATGA	0.617000												
OR8B4	283162	broad.mit.edu	37	11	124294043	124294043	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:124294043G>C	uc010sak.1	-	1	725	c.725C>G	c.(724-726)TCC>TGC	p.S242C		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		AATTATGTGGGAGCCCCATGT	0.463000												
OPCML	4978	broad.mit.edu	37	11	132290089	132290089	+	Nonstop_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr11:132290089A>G	uc001qgs.2	-	7	1086	c.1036T>C	c.(1036-1038)TGA>CGA	p.*346R	OPCML_uc001qgu.2_Nonstop_Mutation_p.*339R|OPCML_uc010sck.1_Nonstop_Mutation_p.*355R|OPCML_uc001qgt.2_Nonstop_Mutation_p.*345R|OPCML_uc010scl.1_Nonstop_Mutation_p.*305R	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	346					cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		ATTTCTTATCAAAACTTGATG	0.478000												
KCNA1	3736	broad.mit.edu	37	12	5020801	5020801	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:5020801G>A	uc001qnh.2	+	2	1362	c.257G>A	c.(256-258)CGG>CAG	p.R86Q		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	86					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GACCGCAACCGGCCCAGCTTC	0.612000												
GAPDH	2597	broad.mit.edu	37	12	6647006	6647006	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:6647006T>C	uc001qop.1	+	8	884	c.782T>C	c.(781-783)GTG>GCG	p.V261A	GAPDH_uc009zep.1_Missense_Mutation_p.V219A|GAPDH_uc001qoq.1_Missense_Mutation_p.V186A|GAPDH_uc001qor.1_Missense_Mutation_p.V220A|GAPDH_uc001qos.1_Missense_Mutation_p.V261A|GAPDH_uc001qot.1_Missense_Mutation_p.V261A|GAPDH_uc001qou.1_Missense_Mutation_p.V220A|GAPDH_uc001qov.1_Missense_Mutation_p.V219A|GAPDH_uc001qow.1_Missense_Mutation_p.V214A|GAPDH_uc001qox.1_Missense_Mutation_p.V87A	NM_002046	NP_002037	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	261					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding				0					NADH(DB00157)	ATCAAGAAGGTGGTGAAGCAG	0.587000											OREG0021628	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
ETV6	2120	broad.mit.edu	37	12	12022503	12022503	+	Silent	SNP	C	C	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:12022503C>G	uc001qzz.2	+	5	883	c.609C>G	c.(607-609)TCC>TCG	p.S203S	ETV6_uc001raa.1_5'UTR	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	203						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CCCTCCGGTCCCCCCTGGACA	0.632000			T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL							
ST8SIA1	6489	broad.mit.edu	37	12	22408298	22408298	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:22408298T>G	uc001rfo.3	-	3	889	c.407A>C	c.(406-408)AAG>ACG	p.K136T	ST8SIA1_uc009zix.2_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	136	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						CGCGCATTTCTTCAATGGCAG	0.478000												
ARID2	196528	broad.mit.edu	37	12	46231349	46231349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:46231349C>T	uc001ros.1	+	10	1189	c.1189C>T	c.(1189-1191)CAG>TAG	p.Q397*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q397*|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q43*|ARID2_uc001rot.1_Nonsense_Mutation_p.Q43*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	397					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATATGTGGATCAGGATTCCTA	0.368000												
SCN8A	6334	broad.mit.edu	37	12	52100394	52100394	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:52100394G>A	uc001ryw.2	+	11	1708	c.1530G>A	c.(1528-1530)GGG>GGA	p.G510G	SCN8A_uc010snl.1_Silent_p.G375G|SCN8A_uc001ryx.1_Silent_p.G375G|SCN8A_uc001ryz.1_Silent_p.G375G|SCN8A_uc001ryy.2_Silent_p.G375G	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	510					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AGGAGAAAGGGGATCCCGAGA	0.453000												
HOXC6	3223	broad.mit.edu	37	12	54423485	54423485	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:54423485G>A	uc001sev.2	+	2	559	c.447G>A	c.(445-447)TCG>TCA	p.S149S	HOXC6_uc001ses.2_Silent_p.S67S|HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron	NM_004503	NP_004494	P09630	HXC6_HUMAN	homeobox C6 isoform 1	149	Homeobox.				regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|upper_aerodigestive_tract(1)	3						AGATCTACTCGCGGTACCAGA	0.597000												
NAV3	89795	broad.mit.edu	37	12	78444720	78444720	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:78444720G>A	uc001syp.2	+	11	2482	c.2309G>A	c.(2308-2310)CGA>CAA	p.R770Q	NAV3_uc001syo.2_Missense_Mutation_p.R770Q|NAV3_uc010sub.1_Missense_Mutation_p.R270Q	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	770						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.R770Q(1)		large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GGTACCAGTCGATTCATCCAC	0.592000										HNSCC(70;0.22)		
LIN7A	8825	broad.mit.edu	37	12	81283099	81283099	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:81283099T>G	uc001szj.1	-	2	325	c.132A>C	c.(130-132)GAA>GAC	p.E44D	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	44	L27.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						GCACTGGTACTTCTCCAGATT	0.333000												
CUX2	23316	broad.mit.edu	37	12	111779799	111779799	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:111779799C>A	uc001tsa.1	+	21	3754	c.3601C>A	c.(3601-3603)CTC>ATC	p.L1201I		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1201	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CATCGAGCTCCTCTCCTTCCA	0.607000												
TMEM132D	121256	broad.mit.edu	37	12	129563232	129563232	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:129563232C>A	uc009zyl.1	-	8	2290	c.1962G>T	c.(1960-1962)AAG>AAT	p.K654N	TMEM132D_uc001uia.2_Missense_Mutation_p.K192N	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	654	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CAGTGATGGTCTTTTCAGCGA	0.567000												
SACS	26278	broad.mit.edu	37	13	23905184	23905184	+	Silent	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr13:23905184A>G	uc001uon.2	-	10	13420	c.12831T>C	c.(12829-12831)CCT>CCC	p.P4277P	SACS_uc001uoo.2_Silent_p.P4130P|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4277					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AGAAAAGAGGAGGAATGCTTC	0.463000												
HSPH1	10808	broad.mit.edu	37	13	31725791	31725791	+	Silent	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr13:31725791T>C	uc001utj.2	-	6	1016	c.618A>G	c.(616-618)TCA>TCG	p.S206S	HSPH1_uc001utk.2_Silent_p.S206S|HSPH1_uc010aaw.2_Silent_p.S165S|HSPH1_uc001utl.2_Silent_p.S208S|HSPH1_uc010tds.1_Intron|HSPH1_uc010tdt.1_Intron	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	206					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CTTGAAAAGCTGAATGTCCCA	0.373000												
NBEA	26960	broad.mit.edu	37	13	36242529	36242529	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr13:36242529C>A	uc001uvb.2	+	57	8829	c.8623C>A	c.(8623-8625)CAG>AAG	p.Q2875K	NBEA_uc010abi.2_Missense_Mutation_p.Q1533K|NBEA_uc010tef.1_Missense_Mutation_p.Q668K|NBEA_uc001uvd.2_Missense_Mutation_p.Q453K	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2875	WD 4.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CAGTGACGGCCAGAACCTGGT	0.418000												
TRPC4	7223	broad.mit.edu	37	13	38229234	38229234	+	Silent	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr13:38229234T>C	uc001uws.2	-	7	2110	c.1875A>G	c.(1873-1875)CAA>CAG	p.Q625Q	TRPC4_uc010abv.2_Silent_p.Q205Q|TRPC4_uc001uwt.2_Silent_p.Q625Q|TRPC4_uc010tey.1_Silent_p.Q625Q|TRPC4_uc010abw.2_Silent_p.Q452Q|TRPC4_uc010abx.2_Silent_p.Q625Q|TRPC4_uc010aby.2_Silent_p.Q625Q	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	625	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		CAGCAATCAGTTGGTAAGAAT	0.338000												
SLITRK5	26050	broad.mit.edu	37	13	88329829	88329829	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr13:88329829C>T	uc001vln.2	+	2	2405	c.2186C>T	c.(2185-2187)GCG>GTG	p.A729V	SLITRK5_uc010tic.1_Missense_Mutation_p.A488V	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	729	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CACCCACACGCGCACGTGCAT	0.657000												
IPO5	3843	broad.mit.edu	37	13	98654779	98654779	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr13:98654779C>T	uc001vnf.1	+	11	1232	c.1167C>T	c.(1165-1167)TGC>TGT	p.C389C	IPO5_uc001vne.2_Silent_p.C407C|IPO5_uc010tik.1_Silent_p.C264C|IPO5_uc010til.1_Silent_p.C329C|IPO5_uc001vng.1_Silent_p.C10C	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	389					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						GTGAAGGGTGCCACCAGCAAA	0.373000												
NALCN	259232	broad.mit.edu	37	13	102030937	102030937	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr13:102030937A>G	uc001vox.1	-	4	548	c.359T>C	c.(358-360)GTT>GCT	p.V120A	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.V120A|NALCN_uc001vpa.2_Missense_Mutation_p.V120A	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	120	Helical; Name=S3 of repeat I; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CACCAAAGAAACCCAAAGGCA	0.308000												
SOX1	6656	broad.mit.edu	37	13	112722355	112722355	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr13:112722355C>T	uc001vsb.1	+	1	443	c.383C>T	c.(382-384)ACG>ATG	p.T128M		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	128					chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		AAGACCAAGACGCTGCTCAAG	0.507000												
TRIM9	114088	broad.mit.edu	37	14	51561231	51561231	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr14:51561231G>A	uc001wyx.3	-	1	1192	c.427C>T	c.(427-429)CGC>TGC	p.R143C	TRIM9_uc001wyy.2_Missense_Mutation_p.R143C|TRIM9_uc001wyz.3_Missense_Mutation_p.R143C	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	143					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					GGGAAGCCGCGGAGCCCCCGG	0.662000												
TMX1	81542	broad.mit.edu	37	14	51721136	51721136	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr14:51721136G>A	uc001wza.3	+	8	867	c.742G>A	c.(742-744)GAA>AAA	p.E248K	TMX1_uc010aoa.2_Missense_Mutation_p.E164K	NM_030755	NP_110382	Q9H3N1	TMX1_HUMAN	thioredoxin domain containing 1 precursor	248	Cytoplasmic (Potential).				anti-apoptosis|cell proliferation|cell redox homeostasis|DNA replication|electron transport chain|ER to Golgi vesicle-mediated transport|leukocyte activation|positive regulation of growth|positive regulation of transcription, DNA-dependent|response to stress|signal transduction	endoplasmic reticulum membrane|integral to membrane|membrane fraction	arsenate reductase (thioredoxin) activity|disulfide oxidoreductase activity				0						AGATGTTTCAGAAGAAGAAGC	0.383000												
FBXO34	55030	broad.mit.edu	37	14	55818684	55818684	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr14:55818684G>T	uc001xbu.2	+	2	1821	c.1576G>T	c.(1576-1578)GGG>TGG	p.G526W	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.G526W	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	526										ovary(2)|lung(2)|skin(1)	5						GGAAAAAAGTGGGTCTGCTGA	0.493000												
KIAA0317	9870	broad.mit.edu	37	14	75143434	75143434	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr14:75143434G>A	uc001xqb.2	-	6	1008	c.503C>T	c.(502-504)ACC>ATC	p.T168I	KIAA0317_uc010tut.1_Missense_Mutation_p.T7I|KIAA0317_uc001xqc.2_Missense_Mutation_p.T168I	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	168					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		CACAATTTTGGTCTTAGAAGG	0.323000												
MARK3	4140	broad.mit.edu	37	14	103934456	103934456	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr14:103934456G>A	uc001ymz.3	+	12	1863	c.1197G>A	c.(1195-1197)CAG>CAA	p.Q399Q	MARK3_uc001ymx.3_Silent_p.Q399Q|MARK3_uc001ymw.3_Silent_p.Q399Q|MARK3_uc001yna.3_Silent_p.Q383Q|MARK3_uc001ymy.3_Silent_p.Q320Q|MARK3_uc010awp.2_Silent_p.Q422Q|MARK3_uc010tyb.1_Silent_p.Q194Q	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	399							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			GTACTGGCCAGTCTCCTCACC	0.448000												
AHNAK2	113146	broad.mit.edu	37	14	105416442	105416442	+	Silent	SNP	C	C	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr14:105416442C>G	uc010axc.1	-	7	5466	c.5346G>C	c.(5344-5346)GTG>GTC	p.V1782V	AHNAK2_uc001ypx.2_Silent_p.V1682V	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1782						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GAGACACCTCCACGTCGGGGG	0.657000												
GANC	2595	broad.mit.edu	37	15	42641627	42641627	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr15:42641627A>G	uc001zpi.2	+	22	2779	c.2465A>G	c.(2464-2466)CAA>CGA	p.Q822R	CAPN3_uc001zpk.1_5'UTR|CAPN3_uc001zpl.1_5'UTR	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	822					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		CATTCATTCCAATACCTCCAC	0.383000												
EPB42	2038	broad.mit.edu	37	15	43494042	43494042	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr15:43494042C>T	uc001zra.3	-	12	2213	c.1913G>A	c.(1912-1914)AGA>AAA	p.R638K	EPB42_uc001zqz.3_Missense_Mutation_p.R305K|EPB42_uc010bde.2_Silent_p.Q429Q|EPB42_uc001zrb.3_Missense_Mutation_p.R668K|EPB42_uc010udm.1_Missense_Mutation_p.R560K	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	638					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		CATCACTTACCTGTAGCTCCT	0.542000												
TP53BP1	7158	broad.mit.edu	37	15	43701941	43701941	+	Splice_Site	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr15:43701941T>C	uc001zrs.2	-	25	5439	c.5291_splice	c.e25-1	p.E1764_splice	TP53BP1_uc010udp.1_Splice_Site_p.E1762_splice|TP53BP1_uc001zrq.3_Splice_Site_p.E1767_splice|TP53BP1_uc001zrr.3_Splice_Site_p.E1769_splice|TP53BP1_uc001zrp.2_Splice_Site_p.E181_splice	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3						double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CCAAAAATTCTATATTAAAAA	0.393000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes				
SEMA6D	80031	broad.mit.edu	37	15	48056124	48056124	+	Silent	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr15:48056124T>G	uc010bek.2	+	10	1185	c.825T>G	c.(823-825)ACT>ACG	p.T275T	SEMA6D_uc001zvw.2_Silent_p.T275T|SEMA6D_uc001zvx.1_Silent_p.T275T|SEMA6D_uc001zvy.2_Silent_p.T275T|SEMA6D_uc001zvz.2_Silent_p.T275T|SEMA6D_uc001zwa.2_Silent_p.T275T|SEMA6D_uc001zwb.2_Silent_p.T275T|SEMA6D_uc001zwc.2_Silent_p.T275T	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	275	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		AACACTGGACTTCATTTCTAA	0.473000												
ADAMTSL3	57188	broad.mit.edu	37	15	84651800	84651800	+	Silent	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr15:84651800C>A	uc002bjz.3	+	21	3644	c.3420C>A	c.(3418-3420)GGC>GGA	p.G1140G	ADAMTSL3_uc010bmt.1_Silent_p.G1140G|ADAMTSL3_uc010bmu.1_Silent_p.G1140G	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1140						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGTGGCGGGGCATCCAGGAAG	0.552000												
RLBP1	6017	broad.mit.edu	37	15	89760498	89760498	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr15:89760498G>T	uc002bnl.2	-	5	579	c.199C>A	c.(199-201)CAG>AAG	p.Q67K		NM_000326	NP_000317	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	67					response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)	1	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	ACCATCTCCTGCAGCTCTCGC	0.632000												
IQGAP1	8826	broad.mit.edu	37	15	91035841	91035841	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr15:91035841C>T	uc002bpl.1	+	35	4627	c.4526C>T	c.(4525-4527)ACA>ATA	p.T1509I	IQGAP1_uc010uqg.1_Missense_Mutation_p.T130I	NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1509	C2.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CTGCAACAGACATACGCTGCT	0.433000												
CHD2	1106	broad.mit.edu	37	15	93467679	93467679	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr15:93467679C>T	uc002bsp.2	+	3	766	c.191C>T	c.(190-192)TCG>TTG	p.S64L	CHD2_uc002bsm.1_Missense_Mutation_p.S64L|CHD2_uc002bsn.2_Missense_Mutation_p.S64L|CHD2_uc002bso.1_Missense_Mutation_p.S64L|CHD2_uc010urb.1_Missense_Mutation_p.S77L	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	64	Ser-rich.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GAGAGTCAGTCGGAATCTGAG	0.527000												
RHOT2	89941	broad.mit.edu	37	16	720267	720267	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr16:720267G>A	uc002cip.2	+	7	415	c.348G>A	c.(346-348)GTG>GTA	p.V116V	RHOT2_uc002ciq.2_Silent_p.V9V|RHOT2_uc010bqy.2_5'Flank	NM_138769	NP_620124	Q8IXI1	MIRO2_HUMAN	ras homolog gene family, member T2	116	Miro 1.|Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			pancreas(1)	1		Hepatocellular(780;0.0218)				TCATCCTAGTGGGCAACAAGT	0.637000												
A2BP1	54715	broad.mit.edu	37	16	7703860	7703860	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr16:7703860C>T	uc002cys.2	+	12	1789	c.801C>T	c.(799-801)TAC>TAT	p.Y267Y	A2BP1_uc010buf.1_Silent_p.Y267Y|A2BP1_uc002cyr.1_Silent_p.Y266Y|A2BP1_uc002cyt.2_Silent_p.Y240Y|A2BP1_uc010uxz.1_Silent_p.Y310Y|A2BP1_uc010uya.1_Silent_p.Y224Y|A2BP1_uc002cyv.1_Silent_p.Y267Y|A2BP1_uc010uyb.1_Silent_p.Y267Y|A2BP1_uc002cyw.2_Silent_p.Y287Y|A2BP1_uc002cyy.2_Silent_p.Y287Y|A2BP1_uc002cyx.2_Silent_p.Y287Y|A2BP1_uc010uyc.1_Silent_p.Y260Y	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	267					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		CGGCCGCCTACCGAGGGGCGC	0.602000												
XYLT1	64131	broad.mit.edu	37	16	17352902	17352902	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr16:17352902G>A	uc002dfa.2	-	3	941	c.856C>T	c.(856-858)CGC>TGC	p.R286C		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	286	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						AACTTGTGGCGGCAGTAAGTC	0.607000												
VWA3A	146177	broad.mit.edu	37	16	22130291	22130291	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr16:22130291C>T	uc010vbq.1	+	12	1155	c.1059C>T	c.(1057-1059)CAC>CAT	p.H353H	VWA3A_uc010bxd.2_5'Flank|VWA3A_uc010bxc.2_Silent_p.H340H	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	353	Potential.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		TCCTCAGCCACGTGCAAGCCC	0.612000												
SLC5A2	6524	broad.mit.edu	37	16	31500028	31500028	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr16:31500028C>T	uc002ecf.3	+	10	1234	c.1215C>T	c.(1213-1215)TTC>TTT	p.F405F	SLC5A2_uc010car.2_Intron|C16orf58_uc002ecg.2_RNA	NM_003041	NP_003032	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose	405	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			ovary(1)	1						GCACGCTCTTCACCATGGACA	0.697000												
CES1	1066	broad.mit.edu	37	16	55857581	55857581	+	Silent	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr16:55857581G>T	uc002eim.2	-	4	525	c.417C>A	c.(415-417)ATC>ATA	p.I139I	CES1_uc002eil.2_Silent_p.I140I|CES1_uc002ein.2_Silent_p.I139I	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	139					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	CCCCTCCGTGGATCCACACCA	0.557000												
KCTD19	146212	broad.mit.edu	37	16	67325601	67325601	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr16:67325601C>T	uc002esu.2	-	13	2409	c.2358G>A	c.(2356-2358)ACG>ACA	p.T786T	KCTD19_uc002est.2_Silent_p.T558T|KCTD19_uc010vjj.1_Silent_p.T529T	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	786						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TGTCCATCTCCGTGGTATAGA	0.607000												
ZCCHC14	23174	broad.mit.edu	37	16	87451107	87451107	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr16:87451107G>A	uc002fjz.1	-	8	958	c.931C>T	c.(931-933)CAC>TAC	p.H311Y	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Missense_Mutation_p.H87Y	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	311					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TAATACTTGTGCAAACGCAGT	0.507000											OREG0024030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
NXN	64359	broad.mit.edu	37	17	729219	729219	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr17:729219T>A	uc002fsa.2	-	2	552	c.460A>T	c.(460-462)ATC>TTC	p.I154F	NXN_uc002fsb.1_Missense_Mutation_p.I41F|NXN_uc002frz.2_5'UTR|NXN_uc010vqe.1_Missense_Mutation_p.I46F	NM_022463	NP_071908	Q6DKJ4	NXN_HUMAN	nucleoredoxin	154					cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			ovary(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		TCATCTCGGATCACCAGCAGC	0.522000												
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
EFNB3	1949	broad.mit.edu	37	17	7611546	7611546	+	Silent	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr17:7611546G>T	uc002gis.2	+	2	790	c.393G>T	c.(391-393)TCG>TCT	p.S131S		NM_001406	NP_001397	Q15768	EFNB3_HUMAN	ephrin-B3 precursor	131	Extracellular (Potential).				cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			ovary(1)	1		all_cancers(10;1.14e-06)|Prostate(122;0.081)				AGTTCCGCTCGCACCACGATT	0.572000												
TAF15	8148	broad.mit.edu	37	17	34160922	34160922	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr17:34160922G>A	uc002hkd.2	+	8	703	c.617G>A	c.(616-618)CGC>CAC	p.R206H	TAF15_uc010ctw.1_Intron|TAF15_uc002hkc.2_Missense_Mutation_p.R203H	NM_139215	NP_631961	Q92804	RBP56_HUMAN	TBP-associated factor 15 isoform 1	206	Gln/Gly/Ser/Tyr-rich.				positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		TAF15/NR4A3(33)	bone(33)|lung(1)|skin(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GGTGGTGACCGCGGTGGCTTC	0.413000			T	TEC|CHN1|ZNF384	extraskeletal myxoid chondrosarcomas|ALL							
KRT35	3886	broad.mit.edu	37	17	39633390	39633390	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr17:39633390G>A	uc002hws.2	-	7	1329	c.1286C>T	c.(1285-1287)GCG>GTG	p.A429V		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	429	Tail.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				GCAGGAGGCCGCAGGAAGACA	0.572000												
DUS1L	64118	broad.mit.edu	37	17	80017925	80017925	+	Missense_Mutation	SNP	C	C	T	rs138475537		TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr17:80017925C>T	uc002kdq.2	-	10	1486	c.1067G>A	c.(1066-1068)CGG>CAG	p.R356Q	DUS1L_uc002kdp.2_Missense_Mutation_p.R225Q|DUS1L_uc002kdr.2_Missense_Mutation_p.R356Q|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	356					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CTCCAGGGCCCGCTTGCTGCG	0.652000												
FASN	2194	broad.mit.edu	37	17	80039961	80039961	+	Silent	SNP	C	C	A	rs146309529		TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr17:80039961C>A	uc002kdu.2	-	36	6204	c.6087G>T	c.(6085-6087)GCG>GCT	p.A2029A	FASN_uc002kdv.1_RNA	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	2029	Beta-ketoacyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TGCTCTGTCCCGCATTGCCAC	0.567000												
L3MBTL4	91133	broad.mit.edu	37	18	6239858	6239858	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr18:6239858G>T	uc002kmz.3	-	9	726	c.566C>A	c.(565-567)TCT>TAT	p.S189Y	L3MBTL4_uc010dkt.2_Missense_Mutation_p.S189Y|L3MBTL4_uc002kmy.3_Missense_Mutation_p.S27Y	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	189	MBT 2.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				AAATTCTTTAGACATTGGCCC	0.468000												
ARHGAP28	79822	broad.mit.edu	37	18	6859866	6859866	+	Silent	SNP	G	G	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr18:6859866G>C	uc010wzi.1	+	4	403	c.165G>C	c.(163-165)GGG>GGC	p.G55G	ARHGAP28_uc002knc.2_Silent_p.G180G|ARHGAP28_uc002knd.2_Silent_p.G73G|ARHGAP28_uc002kne.2_Silent_p.G73G|ARHGAP28_uc002knf.2_Silent_p.G64G			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	55					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				ATAAAGAAGGGAGTTTTGCGG	0.433000												
CTAGE1	64693	broad.mit.edu	37	18	19997725	19997725	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr18:19997725C>T	uc002ktv.1	-	1	154	c.50G>A	c.(49-51)CGT>CAT	p.R17H		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	17	Helical; (Potential).					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AACAGCTGCACGTATCACCAA	0.468000												
DCC	1630	broad.mit.edu	37	18	51053126	51053126	+	Silent	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr18:51053126C>A	uc002lfe.1	+	28	4838	c.4251C>A	c.(4249-4251)GCC>GCA	p.A1417A	DCC_uc010dpf.1_Silent_p.A1050A	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1417	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGGATTCAGCCAATGTAAGGG	0.478000												
MED16	10025	broad.mit.edu	37	19	872114	872114	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:872114G>A	uc002lqd.1	-	12	2061	c.1910C>T	c.(1909-1911)TCC>TTC	p.S637F	MED16_uc010drw.1_Intron|MED16_uc002lqe.2_Missense_Mutation_p.S626F|MED16_uc002lqf.2_Missense_Mutation_p.S626F	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	637	WD 4.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCAGCAGGGAACCCTGCCC	0.627000												
MUC16	94025	broad.mit.edu	37	19	9066275	9066275	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:9066275C>A	uc002mkp.2	-	3	21375	c.21171G>T	c.(21169-21171)AAG>AAT	p.K7057N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7059	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGAATGAGTCTTTGCCTGGG	0.493000												
ZNF439	90594	broad.mit.edu	37	19	11978219	11978219	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:11978219A>C	uc002mss.2	+	3	463	c.335A>C	c.(334-336)AAG>ACG	p.K112T	ZNF439_uc002msr.2_5'UTR	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTCCAGAAGAAGAAAGCTTCT	0.413000												
PVRL2	5819	broad.mit.edu	37	19	45368587	45368587	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:45368587G>A	uc002ozw.1	+	2	538	c.148G>A	c.(148-150)GTG>ATG	p.V50M	PVRL2_uc002ozv.2_Missense_Mutation_p.V50M	NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	50	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		CGGGGGCACCGTGGAGCTGCC	0.642000												
ZNF347	84671	broad.mit.edu	37	19	53645699	53645699	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:53645699C>T	uc002qbb.1	-	5	451	c.382G>A	c.(382-384)GGA>AGA	p.G128R	ZNF347_uc010eql.1_Missense_Mutation_p.G129R|ZNF347_uc002qbc.1_Missense_Mutation_p.G129R	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		AAGGAACATCCTTCAATGTCT	0.398000												
PTPRH	5794	broad.mit.edu	37	19	55693420	55693420	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:55693420C>G	uc002qjq.2	-	19	3235	c.3162G>C	c.(3160-3162)AAG>AAC	p.K1054N	PTPRH_uc010esv.2_Missense_Mutation_p.K876N|SYT5_uc002qjm.1_5'Flank|SYT5_uc002qjp.2_5'Flank|SYT5_uc002qjn.1_5'Flank|SYT5_uc002qjo.1_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1054	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TCTCTCTCATCTTCCTTACAA	0.637000												
BRSK1	84446	broad.mit.edu	37	19	55823347	55823347	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:55823347C>T	uc002qkg.2	+	19	2525	c.2248C>T	c.(2248-2250)CGC>TGC	p.R750C	BRSK1_uc002qkf.2_Missense_Mutation_p.R766C|BRSK1_uc002qkh.2_Missense_Mutation_p.R445C	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	750					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CCCACCCGGCCGCCCAGACCC	0.701000												
NLRP8	126205	broad.mit.edu	37	19	56466131	56466131	+	Missense_Mutation	SNP	A	A	G	rs144060853	byFrequency	TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:56466131A>G	uc002qmh.2	+	3	778	c.707A>G	c.(706-708)AAG>AGG	p.K236R	NLRP8_uc010etg.2_Missense_Mutation_p.K236R	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	236	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TACGCCCACAAGCGCTGGTGT	0.532000												
ZNF470	388566	broad.mit.edu	37	19	57088868	57088868	+	Silent	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:57088868T>C	uc002qnl.3	+	6	1747	c.1071T>C	c.(1069-1071)CAT>CAC	p.H357H	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	357	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		CCCTAGCTCATCATCGAAGGA	0.438000												
PEG3	5178	broad.mit.edu	37	19	57335788	57335788	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:57335788G>T	uc002qnu.2	-	1	587	c.236C>A	c.(235-237)ACC>AAC	p.T79N	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_5'UTR|ZIM2_uc002qnq.2_5'UTR|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_5'UTR|PEG3_uc002qnt.2_Missense_Mutation_p.T79N|PEG3_uc002qnv.2_Missense_Mutation_p.T79N|PEG3_uc002qnw.2_5'UTR|PEG3_uc002qnx.2_5'UTR|PEG3_uc010etr.2_Missense_Mutation_p.T79N	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	79	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTTGGTGCGGGTCTCCGGCTG	0.532000												
PXDN	7837	broad.mit.edu	37	2	1652213	1652213	+	Silent	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:1652213G>T	uc002qxa.2	-	17	3403	c.3339C>A	c.(3337-3339)GGC>GGA	p.G1113G		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1113					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GCGGATCGATGCCGCCCTCAT	0.592000												
PXDN	7837	broad.mit.edu	37	2	1677547	1677547	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:1677547A>C	uc002qxa.2	-	9	950	c.886T>G	c.(886-888)TTG>GTG	p.L296V	PXDN_uc002qxb.1_Missense_Mutation_p.L296V|PXDN_uc002qxc.1_Missense_Mutation_p.L113V	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	296	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCGTCCAGCAAGTTTAGGCGG	0.502000												
PUM2	23369	broad.mit.edu	37	2	20511426	20511426	+	Splice_Site	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:20511426T>C	uc002rds.1	-	4	372	c.349_splice	c.e4-1	p.G117_splice	PUM2_uc002rdt.1_Splice_Site_p.G117_splice|PUM2_uc002rdr.2_Splice_Site_p.G56_splice|PUM2_uc010yjy.1_Splice_Site_p.G117_splice|PUM2_uc002rdu.1_Splice_Site_p.G117_splice|PUM2_uc010yjz.1_Splice_Site_p.G56_splice	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2						regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTAGTGCCCTGAGGAAAAAG	0.383000												
OTOF	9381	broad.mit.edu	37	2	26688846	26688846	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:26688846G>A	uc002rhk.2	-	37	4726	c.4599C>T	c.(4597-4599)ATC>ATT	p.I1533I	OTOF_uc010yla.1_Silent_p.I263I|OTOF_uc002rhh.2_Silent_p.I766I|OTOF_uc002rhi.2_Silent_p.I843I|OTOF_uc002rhj.2_Silent_p.I766I	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1533	Cytoplasmic (Potential).|C2 4.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTGCTTGGAGATGTAGTTCT	0.582000												
CAD	790	broad.mit.edu	37	2	27465519	27465519	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:27465519G>A	uc002rji.2	+	41	6416	c.6254G>A	c.(6253-6255)CGC>CAC	p.R2085H	CAD_uc010eyw.2_Missense_Mutation_p.R2022H	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	2085	ATCase (Aspartate transcarbamylase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AAGCACGGACGCACAGTACAT	0.602000												
CDC42EP3	10602	broad.mit.edu	37	2	37873541	37873541	+	Missense_Mutation	SNP	C	C	T	rs144011190	by1000genomes	TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:37873541C>T	uc002rqi.1	-	2	1183	c.190G>A	c.(190-192)GAG>AAG	p.E64K		NM_006449	NP_006440	Q9UKI2	BORG2_HUMAN	Cdc42 effector protein 3	64					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding				0		all_hematologic(82;0.172)				GGTAAAAGCTCGTAGTTCCCT	0.527000												
GFPT1	2673	broad.mit.edu	37	2	69555475	69555475	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:69555475C>T	uc002sfh.2	-	17	1946	c.1767G>A	c.(1765-1767)GTG>GTA	p.V589V		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	607	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						TGATCATGATCACAGGCATCA	0.438000												
GPAT2	150763	broad.mit.edu	37	2	96697824	96697824	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:96697824G>A	uc002svf.2	-	3	357	c.134C>T	c.(133-135)CCC>CTC	p.P45L	GPAT2_uc002svg.2_5'UTR|GPAT2_uc010yuh.1_Missense_Mutation_p.P45L|GPAT2_uc002svh.2_Missense_Mutation_p.P45L	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	45					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						ACCCACAAAGGGGCGATACTT	0.602000												
EIF5B	9669	broad.mit.edu	37	2	100009484	100009484	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:100009484G>A	uc002tab.2	+	18	2987	c.2803G>A	c.(2803-2805)GGA>AGA	p.G935R	EIF5B_uc010yvq.1_5'Flank	NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	935					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						AAAGATTCTTGGAAAAGACCT	0.343000												
LRP1B	53353	broad.mit.edu	37	2	141250255	141250255	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:141250255T>G	uc002tvj.1	-	57	10014	c.9042A>C	c.(9040-9042)GAA>GAC	p.E3014D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3014	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTAAAAAAGGTTCTTCATCTA	0.338000										TSP Lung(27;0.18)		
SCN9A	6335	broad.mit.edu	37	2	167141141	167141141	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:167141141C>T	uc010fpl.2	-	12	2137	c.1796G>A	c.(1795-1797)AGC>AAC	p.S599N	uc002udp.2_Intron|SCN9A_uc002udr.1_Missense_Mutation_p.S470N|SCN9A_uc002uds.1_Missense_Mutation_p.S470N|SCN9A_uc002udt.1_Missense_Mutation_p.S470N	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	599						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GATGTTACTGCTGCGTCGCTC	0.547000												
TTN	7273	broad.mit.edu	37	2	179654102	179654102	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:179654102T>G	uc010zfg.1	-	13	2285	c.2061A>C	c.(2059-2061)CAA>CAC	p.Q687H	TTN_uc010zfh.1_Missense_Mutation_p.Q641H|TTN_uc010zfi.1_Missense_Mutation_p.Q641H|TTN_uc010zfj.1_Missense_Mutation_p.Q641H|TTN_uc002unb.2_Missense_Mutation_p.Q687H|TTN_uc010frg.1_Missense_Mutation_p.Q269H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	687							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATGGGTAACTTGGATTTGTT	0.353000												
CCDC141	285025	broad.mit.edu	37	2	179702352	179702352	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:179702352T>G	uc002unf.1	-	13	1926	c.1869A>C	c.(1867-1869)GAA>GAC	p.E623D	CCDC141_uc002une.1_Missense_Mutation_p.E73D	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	623							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			AGAGCATGTCTTCAGGCAGGA	0.547000												
DNAH7	56171	broad.mit.edu	37	2	196673538	196673538	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:196673538G>A	uc002utj.3	-	53	10052	c.9951C>T	c.(9949-9951)GCC>GCT	p.A3317A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3317					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TACAAAGGTTGGCATAAGGAT	0.418000												
MDH1B	130752	broad.mit.edu	37	2	207620121	207620121	+	Silent	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:207620121T>C	uc002vbs.2	-	5	577	c.522A>G	c.(520-522)GAA>GAG	p.E174E	MDH1B_uc010ziw.1_Intron|MDH1B_uc010fui.2_Silent_p.E174E|MDH1B_uc010fuj.2_Silent_p.E76E|MDH1B_uc002vbt.2_Intron	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	174					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TGAGATGTTCTTCCGCCTGCT	0.522000												
MAP2	4133	broad.mit.edu	37	2	210558112	210558112	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:210558112A>C	uc002vde.1	+	7	1466	c.1218A>C	c.(1216-1218)AAA>AAC	p.K406N	MAP2_uc002vdc.1_Missense_Mutation_p.K406N|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.K402N	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	406					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TTATGGGGAAAGTTTTAGAGG	0.443000												
FARSB	10056	broad.mit.edu	37	2	223488429	223488429	+	Silent	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:223488429A>C	uc002vne.1	-	13	1226	c.1191T>G	c.(1189-1191)ACT>ACG	p.T397T	FARSB_uc010zlq.1_Silent_p.T417T|FARSB_uc002vnf.1_Silent_p.T298T	NM_005687	NP_005678	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	397					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	GGAGAAGTTCAGTGAGCTTAT	0.393000												
SPHKAP	80309	broad.mit.edu	37	2	228881277	228881277	+	Silent	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:228881277A>G	uc002vpq.2	-	7	4340	c.4293T>C	c.(4291-4293)ATT>ATC	p.I1431I	SPHKAP_uc002vpp.2_Silent_p.I1431I|SPHKAP_uc010zlx.1_Silent_p.I1431I	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1431						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GATCTGTTTCAATCTGAATCA	0.458000												
ALPI	248	broad.mit.edu	37	2	233322819	233322819	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr2:233322819G>A	uc002vst.3	+	8	1045	c.968G>A	c.(967-969)CGC>CAC	p.R323H	ALPI_uc002vsu.3_Missense_Mutation_p.R234H	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	323					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		AGGAACCCCCGCGGCTTCTAC	0.657000												
PCNA	5111	broad.mit.edu	37	20	5099508	5099508	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr20:5099508A>G	uc002wlp.2	-	2	429	c.226T>C	c.(226-228)TCC>CCC	p.S76P	PCNA_uc002wlq.2_Missense_Mutation_p.S76P|PCNA_uc010zqs.1_Missense_Mutation_p.S76P	NM_182649	NP_872590	P12004	PCNA_HUMAN	proliferating cell nuclear antigen	76	Potential.|Interaction with NUDT15.				cell proliferation|DNA strand elongation involved in DNA replication|mismatch repair|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|positive regulation of deoxyribonuclease activity|regulation of DNA replication|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair|translesion synthesis	cytoplasm|DNA replication factor C complex|microtubule cytoskeleton|nuclear replication fork|nucleoplasm|PCNA complex|PCNA-p21 complex	dinucleotide insertion or deletion binding|DNA polymerase processivity factor activity|MutLalpha complex binding|purine-specific mismatch base pair DNA N-glycosylase activity			lung(1)	1						AGTATTTTGGACATACTAGAA	0.458000								DNA_polymerases_(catalytic_subunits)				
PAX1	5075	broad.mit.edu	37	20	21687213	21687213	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr20:21687213G>A	uc002wsj.2	+	2	478	c.424G>A	c.(424-426)GTA>ATA	p.V142I	PAX1_uc010zsl.1_Missense_Mutation_p.V142I|PAX1_uc010zsm.1_Missense_Mutation_p.V118I	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	142	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						GCAGCTCCGCGTATCCCACGG	0.682000												
SDC4	6385	broad.mit.edu	37	20	43964515	43964515	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr20:43964515G>A	uc002xnu.2	-	2	146	c.106C>T	c.(106-108)CGA>TGA	p.R36*	SDC4_uc010zws.1_Intron	NM_002999	NP_002990	P31431	SDC4_HUMAN	syndecan 4 precursor	36	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytoskeletal protein binding|thrombospondin receptor activity				0		Myeloproliferative disorder(115;0.0122)				GAGAAGTATCGGCCTTCTAGG	0.552000												
LIPI	149998	broad.mit.edu	37	21	15538737	15538737	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr21:15538737A>C	uc002yjm.2	-	5	752	c.742T>G	c.(742-744)TTT>GTT	p.F248V	LIPI_uc010gkw.1_Intron	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	227					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTTGGATAAAAATCTATATGT	0.348000												
TMPRSS15	5651	broad.mit.edu	37	21	19725236	19725236	+	Silent	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr21:19725236A>G	uc002ykw.2	-	10	1186	c.1155T>C	c.(1153-1155)ACT>ACC	p.T385T		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	385	Extracellular (Potential).|MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CATTGCCAAAAGTGTGGTCAA	0.358000												
C21orf58	54058	broad.mit.edu	37	21	47731399	47731399	+	Missense_Mutation	SNP	G	G	T	rs13049404	byFrequency	TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr21:47731399G>T	uc002zjf.2	-	7	1826	c.692C>A	c.(691-693)CCT>CAT	p.P231H	C21orf58_uc002ziz.2_Missense_Mutation_p.P148H|C21orf58_uc002zja.2_Missense_Mutation_p.P125H|C21orf58_uc011afw.1_Missense_Mutation_p.P148H|C21orf58_uc002zjc.2_Missense_Mutation_p.P125H|C21orf58_uc011afx.1_Missense_Mutation_p.P125H|C21orf58_uc010gqj.1_RNA	NM_058180	NP_478060	P58505	CU058_HUMAN	hypothetical protein LOC54058	231										pancreas(1)	1	Breast(49;0.112)			Colorectal(79;0.239)		CCGTTGAGTAGGGAAGGCCTG	0.498000												
YPEL1	29799	broad.mit.edu	37	22	22057704	22057704	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr22:22057704G>A	uc002zvl.2	-	4	557	c.225C>T	c.(223-225)GCC>GCT	p.A75A	YPEL1_uc002zvm.2_RNA	NM_013313	NP_037445	O60688	YPEL1_HUMAN	yippee-like 1	75						nucleus					0	Colorectal(54;0.105)					AGTAGATGTCGGCAACCGCAT	0.642000												
SNRPD3	6634	broad.mit.edu	37	22	24953726	24953726	+	Silent	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr22:24953726T>C	uc003aam.1	+	2	524	c.84T>C	c.(82-84)TAT>TAC	p.Y28Y	C22orf13_uc003aah.2_5'Flank|C22orf13_uc003aal.2_5'Flank|C22orf13_uc003aai.3_5'Flank|C22orf13_uc003aaj.3_5'Flank|C22orf13_uc003aak.3_5'Flank|SNRPD3_uc011aju.1_Silent_p.Y28Y	NM_004175	NP_004166	P62318	SMD3_HUMAN	small nuclear ribonucleoprotein polypeptide D3	28					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	enzyme binding|histone pre-mRNA DCP binding			ovary(1)	1						GTGAGGTATATCGGGGGAAGC	0.512000												
MYH9	4627	broad.mit.edu	37	22	36690198	36690198	+	Silent	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr22:36690198G>T	uc003apg.2	-	28	4008	c.3777C>A	c.(3775-3777)GTC>GTA	p.V1259V		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1259	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CGTTGAACTTGACCTGCAGCT	0.672000			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated			
CNTN6	27255	broad.mit.edu	37	3	1418726	1418726	+	Silent	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr3:1418726A>G	uc003boz.2	+	17	2400	c.2133A>G	c.(2131-2133)GGA>GGG	p.G711G	CNTN6_uc011asj.1_Silent_p.G639G|CNTN6_uc003bpa.2_Silent_p.G711G	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	711	Fibronectin type-III 2.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATGGAGGTGGAGGAAGTCGGT	0.398000												
TRAK1	22906	broad.mit.edu	37	3	42260998	42260998	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr3:42260998G>A	uc003cky.2	+	15	2192	c.1976G>A	c.(1975-1977)GGG>GAG	p.G659E	TRAK1_uc011azi.1_Missense_Mutation_p.G638E	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	659					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						CACCATCCTGGGAAGTGCATG	0.473000												
SFMBT1	51460	broad.mit.edu	37	3	52968852	52968852	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr3:52968852G>A	uc003dgf.2	-	6	999	c.430C>T	c.(430-432)CCT>TCT	p.P144S	SFMBT1_uc010hmr.2_Missense_Mutation_p.P91S|SFMBT1_uc003dgg.2_Missense_Mutation_p.P144S|SFMBT1_uc003dgh.2_Missense_Mutation_p.P144S	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	144	MBT 2.				regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		GGAACAGGAGGACTACATGCT	0.428000												
FILIP1L	11259	broad.mit.edu	37	3	99569565	99569565	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr3:99569565G>A	uc003dtm.2	-	5	1418	c.955C>T	c.(955-957)CAA>TAA	p.Q319*	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Nonsense_Mutation_p.Q319*|FILIP1L_uc010hpf.2_Intron|FILIP1L_uc010hpg.2_Nonsense_Mutation_p.Q79*|FILIP1L_uc003dtn.2_Nonsense_Mutation_p.Q79*|FILIP1L_uc003dtp.1_Nonsense_Mutation_p.Q79*	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	319	Potential.					cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						TGGCGATTTTGACTGTCCTCA	0.478000												
TRIM42	287015	broad.mit.edu	37	3	140397174	140397174	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr3:140397174C>T	uc003eto.1	+	1	294	c.103C>T	c.(103-105)CGG>TGG	p.R35W		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	35	Cys-rich.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CACCTCAGAGCGGAACTGCAC	0.527000												
PIGG	54872	broad.mit.edu	37	4	509771	509771	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:509771G>A	uc003gak.3	+	6	1047	c.911G>A	c.(910-912)CGA>CAA	p.R304Q	PIGG_uc003gaj.3_Missense_Mutation_p.R304Q|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Missense_Mutation_p.R171Q|PIGG_uc003gal.3_Missense_Mutation_p.R215Q|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Missense_Mutation_p.R182Q|PIGG_uc003gam.2_Missense_Mutation_p.R215Q|PIGG_uc003gan.2_Missense_Mutation_p.R215Q	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	304	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						GGTGATATCCGACATCCAAAG	0.433000												
WFS1	7466	broad.mit.edu	37	4	6303278	6303278	+	Missense_Mutation	SNP	G	G	A	rs143084511	byFrequency	TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:6303278G>A	uc003giy.2	+	8	1922	c.1756G>A	c.(1756-1758)GCC>ACC	p.A586T	WFS1_uc003gix.2_Missense_Mutation_p.A586T|WFS1_uc003giz.2_Missense_Mutation_p.A404T	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	586					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		GCTGCAGTTCGCCCGGTGGTT	0.667000												
SLIT2	9353	broad.mit.edu	37	4	20487885	20487885	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:20487885T>G	uc003gpr.1	+	7	806	c.602T>G	c.(601-603)CTT>CGT	p.L201R	SLIT2_uc003gps.1_Missense_Mutation_p.L201R	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	201					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATGCCTAAACTTAGGACTTTG	0.323000												
LIMCH1	22998	broad.mit.edu	37	4	41648596	41648596	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:41648596A>C	uc003gvu.3	+	12	1405	c.1351A>C	c.(1351-1353)ACC>CCC	p.T451P	LIMCH1_uc003gvv.3_Missense_Mutation_p.T451P|LIMCH1_uc003gvw.3_Missense_Mutation_p.T451P|LIMCH1_uc003gvx.3_Missense_Mutation_p.T439P|LIMCH1_uc003gwe.3_Missense_Mutation_p.T451P|LIMCH1_uc003gvy.3_Missense_Mutation_p.T280P|LIMCH1_uc003gwa.3_Missense_Mutation_p.T292P|LIMCH1_uc003gvz.3_Missense_Mutation_p.T836P|LIMCH1_uc011byu.1_Missense_Mutation_p.T285P|LIMCH1_uc003gwc.3_Missense_Mutation_p.T297P|LIMCH1_uc003gwd.3_Missense_Mutation_p.T285P|LIMCH1_uc011byv.1_Missense_Mutation_p.T202P	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	451					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						TGAGAGGTTCACCATCAGTGA	0.488000												
BEND4	389206	broad.mit.edu	37	4	42145964	42145964	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:42145964G>T	uc003gwn.2	-	3	1115	c.535C>A	c.(535-537)CTT>ATT	p.L179I	BEND4_uc003gwm.2_Missense_Mutation_p.L179I|BEND4_uc011byy.1_Missense_Mutation_p.L179I	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	179											0						AAGAGGCTAAGAACTCGACTG	0.448000												
GRXCR1	389207	broad.mit.edu	37	4	42895343	42895343	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:42895343C>T	uc003gwt.2	+	1	60	c.60C>T	c.(58-60)ATC>ATT	p.I20I		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	20					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						GGTTTCGGATCGCGTCCTCTC	0.507000												
UGT2B28	54490	broad.mit.edu	37	4	70146482	70146482	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:70146482T>A	uc003hej.2	+	1	266	c.264T>A	c.(262-264)AAT>AAA	p.N88K	UGT2B28_uc010ihr.2_Missense_Mutation_p.N88K	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	88					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	AATTTGAGAATATCATCATGC	0.343000												
C4orf40	401137	broad.mit.edu	37	4	71020099	71020099	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:71020099C>A	uc003hfa.3	+	2	80	c.7C>A	c.(7-9)CTT>ATT	p.L3I	C4orf40_uc003hfb.3_Missense_Mutation_p.L3I	NM_214711	NP_999876	Q6MZM9	CD040_HUMAN	hypothetical protein LOC401137 precursor	3						extracellular region					0						CAAAATGAAGCTTCTCCTTTG	0.284000												
TRPC3	7222	broad.mit.edu	37	4	122853799	122853799	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:122853799C>T	uc003ieg.2	-	2	688	c.614G>A	c.(613-615)CGT>CAT	p.R205H	TRPC3_uc010inr.2_Missense_Mutation_p.R132H|TRPC3_uc003ief.2_Missense_Mutation_p.R132H|TRPC3_uc011cgl.1_5'UTR	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	120	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						CAGAGTGAGACGCTTGCTGGC	0.647000												
EDNRA	1909	broad.mit.edu	37	4	148457038	148457038	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:148457038G>A	uc003iky.2	+	5	1449	c.757G>A	c.(757-759)GAT>AAT	p.D253N	EDNRA_uc011cid.1_Missense_Mutation_p.D28N|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Missense_Mutation_p.D144N	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	253	Extracellular (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	GTTCTACCAAGATGTAAAGGA	0.418000												
DCHS2	54798	broad.mit.edu	37	4	155242139	155242139	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr4:155242139G>A	uc003inw.2	-	14	3047	c.3047C>T	c.(3046-3048)ACG>ATG	p.T1016M		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1016	Cadherin 8.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATGAGATGTCGTCTCATAATC	0.373000												
DNAH5	1767	broad.mit.edu	37	5	13824336	13824336	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:13824336A>T	uc003jfd.2	-	39	6593	c.6551T>A	c.(6550-6552)GTA>GAA	p.V2184E		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2184					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GTCCCGTAGTACACGCATGAC	0.448000									Kartagener_syndrome			
CAPSL	133690	broad.mit.edu	37	5	35910624	35910624	+	Silent	SNP	G	G	A	rs75736388	byFrequency	TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:35910624G>A	uc003jjt.1	-	3	254	c.159C>T	c.(157-159)GAC>GAT	p.D53D	CAPSL_uc003jju.1_Silent_p.D53D	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	53	EF-hand 1.|1 (Potential).					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			GATTATTATCGTCATCCATAA	0.313000												
NIPBL	25836	broad.mit.edu	37	5	37020626	37020626	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:37020626G>A	uc003jkl.3	+	26	5575	c.5076G>A	c.(5074-5076)ATG>ATA	p.M1692I	NIPBL_uc003jkk.3_Missense_Mutation_p.M1692I	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1692					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AAAAAGCAATGAAATCACAAA	0.368000												
C5orf42	65250	broad.mit.edu	37	5	37183749	37183749	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:37183749T>C	uc011cpa.1	-	26	4765	c.4534A>G	c.(4534-4536)AGG>GGG	p.R1512G	C5orf42_uc011coy.1_Missense_Mutation_p.R13G|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.R587G|C5orf42_uc011cpb.1_Missense_Mutation_p.R393G	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1512										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CACATTTTCCTTTTATCAGTT	0.294000												
CMYA5	202333	broad.mit.edu	37	5	79031976	79031976	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:79031976G>T	uc003kgc.2	+	2	7460	c.7388G>T	c.(7387-7389)AGA>ATA	p.R2463I		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2463						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTGGAAAACAGATCATATACC	0.363000												
GPR98	84059	broad.mit.edu	37	5	89949196	89949196	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:89949196T>G	uc003kju.2	+	20	3901	c.3805T>G	c.(3805-3807)TTC>GTC	p.F1269V	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1269	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATTACCAACTTCACCATTTT	0.433000												
FBN2	2201	broad.mit.edu	37	5	127614390	127614390	+	Missense_Mutation	SNP	G	G	A	rs1801169		TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:127614390G>A	uc003kuu.2	-	57	7721	c.7282C>T	c.(7282-7284)CCT>TCT	p.P2428S		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2428	TB 9.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCAGTTCCAGGAAGTGGGCAA	0.478000												
PCDHA1	56147	broad.mit.edu	37	5	140168138	140168138	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:140168138C>T	uc003lhb.2	+	1	2263	c.2263C>T	c.(2263-2265)CGG>TGG	p.R755W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.R755W	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	755	Cytoplasmic (Potential).|5 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGCAGAGGCGGCAGAGGGT	0.617000												
PCDHA13	56136	broad.mit.edu	37	5	140263569	140263569	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:140263569C>T	uc003lif.2	+	1	1716	c.1716C>T	c.(1714-1716)AGC>AGT	p.S572S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.S572S|PCDHA13_uc003lid.2_Silent_p.S572S	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	572	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCTGGCAGCGCGGGAGGCA	0.697000												
CYFIP2	26999	broad.mit.edu	37	5	156816394	156816394	+	Silent	SNP	C	C	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:156816394C>T	uc003lwq.2	+	31	3543	c.3405C>T	c.(3403-3405)TTC>TTT	p.F1135F	CYFIP2_uc011ddn.1_Silent_p.F1109F|CYFIP2_uc011ddo.1_Silent_p.F939F|CYFIP2_uc003lwr.2_Silent_p.F1135F|CYFIP2_uc003lws.2_Silent_p.F1135F|CYFIP2_uc003lwt.2_Silent_p.F1038F|CYFIP2_uc011ddp.1_Silent_p.F869F|CYFIP2_uc003lwv.2_Silent_p.F90F	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1160					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCATGCAGTTCGTGTACTGCA	0.617000												
HMMR	3161	broad.mit.edu	37	5	162901197	162901197	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr5:162901197C>A	uc003lzf.2	+	10	1218	c.1036C>A	c.(1036-1038)CTG>ATG	p.L346M	HMMR_uc003lzh.2_Missense_Mutation_p.L347M|HMMR_uc003lzg.2_Missense_Mutation_p.L331M|HMMR_uc011dem.1_Missense_Mutation_p.L260M	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	346						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		TGATTCACTTCTGCAACAAGA	0.274000												
NUP153	9972	broad.mit.edu	37	6	17675564	17675564	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr6:17675564G>C	uc003ncd.1	-	4	819	c.619C>G	c.(619-621)CTG>GTG	p.L207V	NUP153_uc011dje.1_Missense_Mutation_p.L207V|NUP153_uc010jpl.1_Missense_Mutation_p.L207V	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	207					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GGGGACCACAGAGGTGGCAAT	0.393000												
TMEM200A	114801	broad.mit.edu	37	6	130761908	130761908	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr6:130761908G>A	uc003qca.2	+	3	1212	c.341G>A	c.(340-342)CGC>CAC	p.R114H	TMEM200A_uc010kfh.2_Missense_Mutation_p.R114H|TMEM200A_uc010kfi.2_Missense_Mutation_p.R114H|TMEM200A_uc003qcb.2_Missense_Mutation_p.R114H	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	114	Extracellular (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GTGGTGGTTCGCTTCTTTGAG	0.408000												
GPR141	353345	broad.mit.edu	37	7	37780254	37780254	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr7:37780254T>G	uc003tfm.1	+	1	259	c.259T>G	c.(259-261)TTC>GTC	p.F87V	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	87	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						TGGGCTGCCCTTCTGCAAATT	0.488000												
AMPH	273	broad.mit.edu	37	7	38534094	38534094	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr7:38534094G>A	uc003tgu.2	-	4	308	c.239C>T	c.(238-240)TCG>TTG	p.S80L	AMPH_uc003tgv.2_Missense_Mutation_p.S80L	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	80	BAR.|Potential.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TTCATGCAGCGACTCTGTGAG	0.532000												
ZNF107	51427	broad.mit.edu	37	7	64168394	64168394	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr7:64168394A>G	uc003ttd.2	+	7	2498	c.1712A>G	c.(1711-1713)AAG>AGG	p.K571R	ZNF107_uc003tte.2_Missense_Mutation_p.K571R	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	571	C2H2-type 18; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				ACTACACAAAAGATAATTCAT	0.323000												
CDK14	5218	broad.mit.edu	37	7	90546950	90546950	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr7:90546950A>T	uc003uky.2	+	8	959	c.737A>T	c.(736-738)TAC>TTC	p.Y246F	CDK14_uc003ukz.1_Missense_Mutation_p.Y228F|CDK14_uc010les.1_Missense_Mutation_p.Y200F|CDK14_uc011khl.1_Missense_Mutation_p.Y117F	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	246	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						GGTCTGTCTTACATCCACCAG	0.413000												
PON1	5444	broad.mit.edu	37	7	94937461	94937461	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr7:94937461A>G	uc003uns.2	-	6	657	c.560T>C	c.(559-561)CTT>CCT	p.L187P	PON1_uc011kih.1_Missense_Mutation_p.L187P	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	187					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	GTAGGGGTCAAGAAAATAGTG	0.388000												
DNAJB6	10049	broad.mit.edu	37	7	157177654	157177654	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr7:157177654T>C	uc003wnk.2	+	7	726	c.572T>C	c.(571-573)ATA>ACA	p.I191T	DNAJB6_uc003wnj.2_Missense_Mutation_p.I191T|DNAJB6_uc003wnl.2_Missense_Mutation_p.I178T|DNAJB6_uc011kvy.1_Missense_Mutation_p.I142T|DNAJB6_uc011kvz.1_Intron|DNAJB6_uc010lqt.2_Missense_Mutation_p.I191T	NM_058246	NP_490647	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	191	Interaction with KRT18.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			ovary(2)	2	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		TTCAAATCGATATCAACTTCA	0.408000												
MCPH1	79648	broad.mit.edu	37	8	6312749	6312749	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:6312749G>T	uc003wqi.2	+	9	1979	c.1911G>T	c.(1909-1911)TTG>TTT	p.L637F		NM_024596	NP_078872	Q8NEM0	MCPH1_HUMAN	microcephalin	637						microtubule organizing center				central_nervous_system(1)|skin(1)	2		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		ATGAGGAATTGAAGAAAAGTG	0.368000												
DLC1	10395	broad.mit.edu	37	8	13357278	13357278	+	Silent	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:13357278T>C	uc003wwm.2	-	2	747	c.303A>G	c.(301-303)GAA>GAG	p.E101E	DLC1_uc003wwn.2_Silent_p.E101E|DLC1_uc011kxy.1_Silent_p.E101E	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	101					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						CTGTGCTGGCTTCCAGAGAAA	0.423000												
PSD3	23362	broad.mit.edu	37	8	18729760	18729760	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:18729760G>A	uc003wza.2	-	3	717	c.614C>T	c.(613-615)ACG>ATG	p.T205M		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	205					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ACTTTCCTCCGTTGTTACTTC	0.438000												
UNC5D	137970	broad.mit.edu	37	8	35425650	35425650	+	Silent	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:35425650T>C	uc003xjr.1	+	3	685	c.357T>C	c.(355-357)ACT>ACC	p.T119T	UNC5D_uc003xjs.1_Silent_p.T114T	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	119	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TCAATGTTACTAGGCAACAGG	0.512000												
DKK4	27121	broad.mit.edu	37	8	42231770	42231770	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:42231770C>G	uc003xpb.2	-	4	634	c.523G>C	c.(523-525)GTC>CTC	p.V175L		NM_014420	NP_055235	Q9UBT3	DKK4_HUMAN	dickkopf homolog 4 precursor	175	DKK-type Cys-2.				multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				ovary(1)	1	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			CTGGAGCAGACCTGTCCCTCC	0.502000												
PXDNL	137902	broad.mit.edu	37	8	52323896	52323896	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:52323896G>A	uc003xqu.3	-	16	2077	c.1976C>T	c.(1975-1977)GCA>GTA	p.A659V	PXDNL_uc003xqt.3_5'Flank	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	659					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCCTGCTCTTGCCATTTCCAC	0.502000												
TCEA1	6917	broad.mit.edu	37	8	54891686	54891686	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:54891686T>C	uc003xru.2	-	8	1047	c.724A>G	c.(724-726)AAA>GAA	p.K242E	TCEA1_uc003xrv.2_Missense_Mutation_p.K221E|TCEA1_uc011ldw.1_Missense_Mutation_p.K58E|TCEA1_uc010lyg.2_RNA	NM_006756	NP_006747	P23193	TCEA1_HUMAN	transcription elongation factor A 1 isoform 1	242	TFIIS central.				positive regulation of viral transcription|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	nucleoplasm	DNA binding|translation elongation factor activity|zinc ion binding				0		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;9.1e-07)|Epithelial(17;9.44e-05)|all cancers(17;0.000699)			ATGGCTTCTTTGGTCAAGTTT	0.438000			T	PLAG1	salivary adenoma							
VPS13B	157680	broad.mit.edu	37	8	100729456	100729456	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:100729456G>A	uc003yiv.2	+	37	6698	c.6587G>A	c.(6586-6588)AGT>AAT	p.S2196N	VPS13B_uc003yiw.2_Missense_Mutation_p.S2171N	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2196					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTTAAAACAAGTCTCAAAGAA	0.383000												
ZNF34	80778	broad.mit.edu	37	8	145998712	145998712	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:145998712C>A	uc003zdy.3	-	6	1724	c.1622G>T	c.(1621-1623)CGG>CTG	p.R541L	ZNF34_uc010mgb.2_Missense_Mutation_p.R438L|ZNF34_uc003zdx.3_Missense_Mutation_p.R520L	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	541	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		GGAACTGTGCCGGAAGGCCTT	0.587000												
BNC2	54796	broad.mit.edu	37	9	16436469	16436469	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr9:16436469T>G	uc003zml.2	-	6	1863	c.1723A>C	c.(1723-1725)AGT>CGT	p.S575R	BNC2_uc011lmw.1_Missense_Mutation_p.S480R|BNC2_uc003zmm.2_Missense_Mutation_p.S533R|BNC2_uc003zmq.1_Missense_Mutation_p.S589R|BNC2_uc003zmr.1_Missense_Mutation_p.S612R|BNC2_uc003zmp.1_Missense_Mutation_p.S603R|BNC2_uc010mij.1_Missense_Mutation_p.S497R|BNC2_uc011lmv.1_Missense_Mutation_p.S401R|BNC2_uc003zmo.1_Missense_Mutation_p.S497R|BNC2_uc003zmj.2_Missense_Mutation_p.S340R|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.S340R|BNC2_uc003zmn.1_Missense_Mutation_p.S340R	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	575	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GTGAGTAAACTTCTATAAAAT	0.517000												
SETX	23064	broad.mit.edu	37	9	135202556	135202556	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr9:135202556T>A	uc004cbk.2	-	10	4612	c.4429A>T	c.(4429-4431)ATG>TTG	p.M1477L	SETX_uc004cbj.2_Missense_Mutation_p.M1096L|SETX_uc010mzt.2_Missense_Mutation_p.M1096L	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1477					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		AAAGCTGCCATCTCTATATGA	0.413000												
BARHL1	56751	broad.mit.edu	37	9	135462862	135462862	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr9:135462862G>A	uc004cbp.1	+	2	805	c.613G>A	c.(613-615)GTG>ATG	p.V205M		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	205	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		GTACCTGAGCGTGCAGGACCG	0.667000												
TRO	7216	broad.mit.edu	37	X	54956444	54956444	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chrX:54956444A>T	uc004dtq.2	+	12	3394	c.3287A>T	c.(3286-3288)AAC>ATC	p.N1096I	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.N627I|TRO_uc004dtw.2_Missense_Mutation_p.N699I|TRO_uc004dtx.2_Missense_Mutation_p.N479I	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1096	29.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						CCAATCACCAACCCTGGCTTT	0.572000												
MSN	4478	broad.mit.edu	37	X	64949468	64949468	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chrX:64949468A>G	uc004dwf.2	+	4	559	c.361A>G	c.(361-363)ACC>GCC	p.T121A		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	121	FERM.				leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						CCCGCCTGAGACCGCTGTGCT	0.512000			T	ALK	ALCL							
PCDH11X	27328	broad.mit.edu	37	X	91133636	91133636	+	Silent	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chrX:91133636G>A	uc004efk.1	+	2	3242	c.2397G>A	c.(2395-2397)GAG>GAA	p.E799E	PCDH11X_uc004efl.1_Silent_p.E799E|PCDH11X_uc004efo.1_Silent_p.E799E|PCDH11X_uc010nmv.1_Silent_p.E799E|PCDH11X_uc004efm.1_Silent_p.E799E|PCDH11X_uc004efn.1_Silent_p.E799E|PCDH11X_uc004efh.1_Silent_p.E799E|PCDH11X_uc004efj.1_Silent_p.E799E	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	799	Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CAAATACTGAGATAGCTGATG	0.443000												
ATP11C	286410	broad.mit.edu	37	X	138856961	138856961	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chrX:138856961T>G	uc004faz.2	-	19	2212	c.2113A>C	c.(2113-2115)ACA>CCA	p.T705P	ATP11C_uc004fay.2_RNA|ATP11C_uc004fba.2_Missense_Mutation_p.T705P	NM_173694	NP_775965	Q8NB49	AT11C_HUMAN	ATPase, class VI, type 11C isoform a	705	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(5)|large_intestine(3)	8	Acute lymphoblastic leukemia(192;0.000127)					ATGGTTTTTGTGGTTAGTTCT	0.413000												
PRRG3	79057	broad.mit.edu	37	X	150869097	150869097	+	Silent	SNP	C	C	G			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chrX:150869097C>G	uc004few.1	+	4	678	c.288C>G	c.(286-288)GCC>GCG	p.A96A		NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	proline rich Gla (G-carboxyglutamic acid) 3	96	Helical; (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTCATCGCCTTGTTCATCA	0.597000												
ATP2B3	492	broad.mit.edu	37	X	152813388	152813388	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chrX:152813388G>A	uc004fht.1	+	7	1180	c.1054G>A	c.(1054-1056)GCA>ACA	p.A352T	ATP2B3_uc004fhs.1_Missense_Mutation_p.A352T	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	352	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAAAGCCAACGCACCCAAAAA	0.597000												
CDC73	79577	broad.mit.edu	37	1	193107220	193107221	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr1:193107220_193107221delAG	uc001gtb.2	+	6	672_673	c.429_430delAG	c.(427-432)GAAGAGfs	p.E143fs		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	143_144					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						TCCAGGATGAAGAGTGTGTGCG	0.366									Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome			
IKBIP	121457	broad.mit.edu	37	12	99007790	99007790	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:99007790delT	uc001tfv.2	-	3	736	c.626delA	c.(625-627)AATfs	p.N209fs	IKBIP_uc001tfw.2_3'UTR	NM_201612	NP_963906	Q70UQ0	IKIP_HUMAN	IKK interacting protein isoform 2	209	Potential.				induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TTTTACTGTATTTTTTTCTAC	0.318												
ZNF177	7730	broad.mit.edu	37	19	9489708	9489708	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:9489708delA	uc002mli.2	+	9	767	c.104delA	c.(103-105)CAAfs	p.Q35fs	ZNF177_uc002mlj.2_5'UTR|ZNF177_uc002mlk.2_Frame_Shift_Del_p.Q35fs	NM_003451	NP_003442	Q13360	ZN177_HUMAN	zinc finger protein 177	35	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GACCCTGCTCAAAAAAATCTA	0.413												
NOP56	10528	broad.mit.edu	37	20	2638596	2638598	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr20:2638596_2638598delAAG	uc002wgh.2	+	12	1494_1496	c.1441_1443delAAG	c.(1441-1443)AAGdel	p.K484del	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_In_Frame_Del_p.K318del|NOP56_uc002wgm.1_3'UTR	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	484	Lys-rich.				rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						AAAACCCAAAAAGAAGAAAAAGC	0.443												
FLJ43860	389690	broad.mit.edu	37	8	142490526	142490526	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr8:142490526delA	uc003ywi.2	-	7	854	c.773delT	c.(772-774)TTCfs	p.F258fs	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	258							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CGTGCTCAGGAACGGGACTGA	0.632												
GOLGA3	2802	broad.mit.edu	37	12	133357449	133357449	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr12:133357448_133357448AG>A	uc001ukz.1	-	17	4077	c.3518_3518CT>T	c.(3517-3519)cttfs	p.L1173fs	GOLGA3_uc021rgt.1_Non-coding_Transcript|GOLGA3_uc001ula.1_Frame_Shift_Del_p.L1173fs	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Homo sapiens golgin A3 (GOLGA3), transcript variant 1, mRNA.	1173					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GGCCTGGACAAGATGCTTCAT	0.542												
ZNF521	25925	broad.mit.edu	37	18	22806953	22806955	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr18:22806952_22806954GTTC>G	uc002kvk.2	-	3	1175_1177	c.928_930GAAC>C	c.(928-930)aac>C	p.N310del	ZNF521_uc010xbe.1_Non-coding_Transcript|ZNF521_uc010dly.2_In_Frame_Del_p.N310del|ZNF521_uc002kvl.2_In_Frame_Del_p.N90del	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	Homo sapiens zinc finger protein 521 (ZNF521), mRNA.	310					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TGCTGCATGAGTTCTTCTTCTCC	0.547			T	PAX5	ALL							
LILRA1	11024	broad.mit.edu	37	19	55107789	55107790	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D7-6525-01A-11D-1800-08	TCGA-D7-6525-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1802f450-e90b-4642-9408-cc9736df76b5	3cbf6b07-f408-4018-a236-41c3e280c557	g.chr19:55107788_55107789G>GC	uc002qgh.1	+	6	1275_1276	c.1093_1094G>GC	c.(1093-1095)gccfs	p.A365fs	LILRA1_uc010yfg.1_Frame_Shift_Ins_p.A363fs|LILRA1_uc010yfh.2_Frame_Shift_Ins_p.A365fs	NM_006863	NP_006854	O75019	LIRA1_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 (LILRA1), mRNA.	365	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		AGCAGCTGATGCCCCCCTCCGT	0.589