Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
LPHN2	23266	broad.mit.edu	37	1	82456569	82456569	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr1:82456569A>C	uc001dit.3	+	21	4133	c.3952A>C	c.(3952-3954)AGC>CGC	p.S1318R	LPHN2_uc001dis.2_Missense_Mutation_p.S298R|LPHN2_uc001diu.2_Missense_Mutation_p.S1318R|LPHN2_uc001div.2_3'UTR|LPHN2_uc009wcd.2_3'UTR|LPHN2_uc001diw.2_Missense_Mutation_p.S945R	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	1374	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TCTTTATACAAGCATGCCCAA	0.493000												
C1orf51	148523	broad.mit.edu	37	1	150256881	150256881	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr1:150256881G>A	uc001euh.2	+	4	624	c.488G>A	c.(487-489)CGT>CAT	p.R163H	C1orf51_uc001eui.2_Missense_Mutation_p.R75H|C1orf51_uc001euj.2_Missense_Mutation_p.R163H	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	163											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGATCCAGCGTATTGTAGGT	0.468000												
SPTA1	6708	broad.mit.edu	37	1	158617375	158617375	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr1:158617375T>C	uc001fst.1	-	27	4049	c.3850A>G	c.(3850-3852)AGC>GGC	p.S1284G		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1284	Spectrin 12.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCATTTAGGCTCTCCTTACGA	0.542000												
TNR	7143	broad.mit.edu	37	1	175355352	175355352	+	Silent	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr1:175355352G>T	uc001gkp.1	-	6	1674	c.1593C>A	c.(1591-1593)GTC>GTA	p.V531V	TNR_uc009wwu.1_Silent_p.V531V	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	531	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GAATGAAATCGACTTTGGCTC	0.577000												
FAM89A	375061	broad.mit.edu	37	1	231155737	231155737	+	Missense_Mutation	SNP	C	C	T	rs61740910	byFrequency	TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr1:231155737C>T	uc001hui.2	-	2	465	c.427G>A	c.(427-429)GAT>AAT	p.D143N	FAM89A_uc009xfm.2_Missense_Mutation_p.D154N|MIR1182_hsa-mir-1182|MI0006275_5'Flank	NM_198552	NP_940954	Q96GI7	FA89A_HUMAN	family with sequence similarity 89, member A	143											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TCCTCTTCATCGAAGAAGCCG	0.587000												
B3GALNT2	148789	broad.mit.edu	37	1	235629002	235629002	+	Silent	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr1:235629002G>A	uc001hxc.2	-	7	1021	c.792C>T	c.(790-792)TTC>TTT	p.F264F	B3GALNT2_uc001hxd.1_Silent_p.F305F	NM_152490	NP_689703	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	264	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			breast(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			CACCTTCCAAGAATTCATGAG	0.363000												
OR6F1	343169	broad.mit.edu	37	1	247875986	247875986	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr1:247875986C>A	uc001idj.1	-	1	72	c.72G>T	c.(70-72)CAG>CAT	p.Q24H		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AGAGAGAGAGCTGAAGAGTTT	0.463000												
OR2M4	26245	broad.mit.edu	37	1	248402739	248402739	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr1:248402739G>T	uc010pzh.1	+	1	509	c.509G>T	c.(508-510)AGC>ATC	p.S170I		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCTTACTGCAGCTCTCTGGAA	0.433000												
GTPBP4	23560	broad.mit.edu	37	10	1053033	1053033	+	Silent	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr10:1053033C>T	uc001ift.2	+	10	1149	c.1078C>T	c.(1078-1080)CTG>TTG	p.L360L	GTPBP4_uc010qac.1_Silent_p.L151L|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Silent_p.L244L|GTPBP4_uc010qae.1_Silent_p.L313L	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	360					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		GCTGAATAGACTGCACCTGGC	0.507000												
PRKG1	5592	broad.mit.edu	37	10	54041923	54041923	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr10:54041923G>C	uc001jjm.2	+	14	1705	c.1511G>C	c.(1510-1512)GGC>GCC	p.G504A	PRKG1_uc001jjo.2_Missense_Mutation_p.G519A|PRKG1_uc009xow.1_Missense_Mutation_p.G222A|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	504	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		GTTGATTTTGGCTTTGCAAAG	0.343000												
BICC1	80114	broad.mit.edu	37	10	60588555	60588555	+	Silent	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr10:60588555G>A	uc001jki.1	+	21	2829	c.2829G>A	c.(2827-2829)TCG>TCA	p.S943S		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	943					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TTTTTGAATCGCCAAATGCAC	0.468000												
C11orf35	256329	broad.mit.edu	37	11	557633	557633	+	Missense_Mutation	SNP	G	G	A	rs138095963		TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr11:557633G>A	uc001lpx.2	-	6	626	c.563C>T	c.(562-564)ACG>ATG	p.T188M	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	188										pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGTCTCTGCCGTCACTACCTG	0.612000												
UBQLN3	50613	broad.mit.edu	37	11	5528867	5528867	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr11:5528867G>A	uc001may.1	-	2	2008	c.1922C>T	c.(1921-1923)ACG>ATG	p.T641M	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	641	UBA.									ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCGCCCCCCGTAGCAATGAG	0.537000												
MRGPRX3	117195	broad.mit.edu	37	11	18159146	18159146	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr11:18159146C>T	uc001mnu.2	+	3	758	c.397C>T	c.(397-399)CGC>TGC	p.R133C		NM_054031	NP_473372	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	133	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2						GTACCACTGCCGCCGCCCCAG	0.572000												
OR8J1	219477	broad.mit.edu	37	11	56128624	56128624	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr11:56128624C>A	uc010rjh.1	+	1	902	c.902C>A	c.(901-903)GCT>GAT	p.A301D		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTGAAGACTGCTCTACAGAGA	0.368000												
TRPC6	7225	broad.mit.edu	37	11	101375501	101375501	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr11:101375501G>A	uc001pgk.3	-	2	624	c.199C>T	c.(199-201)CGG>TGG	p.R67W	TRPC6_uc009ywy.2_Missense_Mutation_p.R67W|TRPC6_uc009ywz.1_Missense_Mutation_p.R67W	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	67	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		GTCTGCCGCCGGTGAGCCAGT	0.463000												
MCAM	4162	broad.mit.edu	37	11	119182655	119182655	+	Missense_Mutation	SNP	C	C	A	rs1131437		TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr11:119182655C>A	uc001pwf.2	-	10	1177	c.1148G>T	c.(1147-1149)GGC>GTC	p.G383V	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	383	Ig-like C2-type 2.|Extracellular (Potential).			G -> D (in Ref. 1, 2 and 3).	anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CAGCACCTGGCCTGTCTGGGA	0.642000												
HEPACAM	220296	broad.mit.edu	37	11	124794667	124794667	+	Silent	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr11:124794667G>A	uc001qbk.2	-	2	790	c.384C>T	c.(382-384)GAC>GAT	p.D128D	HEPACAM_uc009zbj.2_5'Flank|HEPACAM_uc001qbl.1_Silent_p.D128D	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	128	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TGAAGGTGTCGTCGGTGATGG	0.552000												
FGF6	2251	broad.mit.edu	37	12	4553300	4553300	+	Missense_Mutation	SNP	G	G	A	rs140216440		TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr12:4553300G>A	uc001qmr.1	-	2	493	c.449C>T	c.(448-450)ACG>ATG	p.T150M		NM_020996	NP_066276	P10767	FGF6_HUMAN	fibroblast growth factor 6 precursor	150					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			lung(2)|ovary(1)	3			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			TGAACTCACCGTTGCGTACAA	0.478000												
CLEC1B	51266	broad.mit.edu	37	12	10147790	10147790	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr12:10147790T>A	uc001qwu.2	-	5	694	c.494A>T	c.(493-495)AAG>ATG	p.K165M	CLEC1B_uc009zhd.2_Missense_Mutation_p.K132M	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	165	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						CTCATTCGACTTCTGGCGAGA	0.423000												
IAPP	3375	broad.mit.edu	37	12	21531349	21531349	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr12:21531349T>A	uc001rev.2	+	3	411	c.259T>A	c.(259-261)TTG>ATG	p.L87M	SLCO1A2_uc001res.2_Intron|SLCO1A2_uc010siq.1_Intron	NM_000415	NP_000406	P10997	IAPP_HUMAN	islet amyloid polypeptide precursor	87					apoptosis|cell-cell signaling|endocrine pancreas development|signal transduction	extracellular region|soluble fraction	hormone activity				0					Perindopril(DB00790)	ACTGAATTACTTGCCCCTTTA	0.383000												
PPFIBP1	8496	broad.mit.edu	37	12	27829368	27829368	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr12:27829368C>T	uc001ric.1	+	18	1846	c.1469C>T	c.(1468-1470)GCT>GTT	p.A490V	PPFIBP1_uc010sjr.1_Missense_Mutation_p.A321V|PPFIBP1_uc001rib.1_Missense_Mutation_p.A473V|PPFIBP1_uc001ria.2_Missense_Mutation_p.A459V|PPFIBP1_uc001rid.1_Missense_Mutation_p.A337V|PPFIBP1_uc001rif.1_5'Flank	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	490					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					CAGGACAGAGCTCCGGCAGAA	0.552000												
PDZRN4	29951	broad.mit.edu	37	12	41946487	41946487	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr12:41946487A>C	uc010skn.1	+	6	704	c.636A>C	c.(634-636)CAA>CAC	p.Q212H	PDZRN4_uc001rmq.3_Missense_Mutation_p.Q153H|PDZRN4_uc009zjz.2_Missense_Mutation_p.Q151H|PDZRN4_uc001rmr.2_Missense_Mutation_p.Q38H	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	411	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTAGCAGTCAAGAGAAGCTGG	0.468000												
E2F7	144455	broad.mit.edu	37	12	77417916	77417916	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr12:77417916G>A	uc001sym.3	-	13	2851	c.2615C>T	c.(2614-2616)ACG>ATG	p.T872M	E2F7_uc009zse.2_3'UTR	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	872					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						CTTGAAAAACGTCTCACGATG	0.473000												
TCTN2	79867	broad.mit.edu	37	12	124171418	124171418	+	Silent	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr12:124171418G>T	uc001ufp.2	+	6	728	c.600G>T	c.(598-600)CGG>CGT	p.R200R	TCTN2_uc009zya.2_Silent_p.R199R	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	200	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TGTTCAGACGGTCCTGCTTCA	0.532000												
FRY	10129	broad.mit.edu	37	13	32760399	32760399	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr13:32760399C>G	uc001utx.2	+	27	3818	c.3322C>G	c.(3322-3324)CAC>GAC	p.H1108D	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTCCCTAGTTCACCACCGAAG	0.413000												
PRKCH	5583	broad.mit.edu	37	14	61917668	61917668	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr14:61917668C>T	uc001xfn.2	+	6	1116	c.811C>T	c.(811-813)CGA>TGA	p.R271*	PRKCH_uc010tsa.1_Nonsense_Mutation_p.R110*	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	271	Phorbol-ester/DAG-type 2.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		GGGAATAATGCGACAAGGACT	0.488000												
RGS6	9628	broad.mit.edu	37	14	72976881	72976881	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr14:72976881C>T	uc001xna.3	+	14	1508	c.985C>T	c.(985-987)CGA>TGA	p.R329*	RGS6_uc010ttn.1_Nonsense_Mutation_p.R329*|RGS6_uc001xmx.3_Nonsense_Mutation_p.R329*|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Nonsense_Mutation_p.R329*|RGS6_uc010ttp.1_Nonsense_Mutation_p.R260*|RGS6_uc001xmz.1_Nonsense_Mutation_p.R190*	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	329	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAGCCAACAGCGAGTAAAAAG	0.458000												
TP53BP1	7158	broad.mit.edu	37	15	43699759	43699759	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr15:43699759A>G	uc001zrs.2	-	28	5889	c.5741T>C	c.(5740-5742)TTA>TCA	p.L1914S	TP53BP1_uc010udp.1_Missense_Mutation_p.L1912S|TP53BP1_uc001zrq.3_Missense_Mutation_p.L1917S|TP53BP1_uc001zrr.3_Missense_Mutation_p.L1919S|TP53BP1_uc001zrp.2_Missense_Mutation_p.L331S	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1914	BRCT 2.				double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		AAATACCCCTAAAGCAATATC	0.493000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes				
ACAN	176	broad.mit.edu	37	15	89382268	89382268	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr15:89382268G>A	uc010upo.1	+	3	819	c.445G>A	c.(445-447)GTG>ATG	p.V149M	ACAN_uc002bmx.2_Missense_Mutation_p.V149M|ACAN_uc010upp.1_Missense_Mutation_p.V149M|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	149					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCTGGAAGTCGTGGTGAAAGG	0.557000												
ACSM2B	348158	broad.mit.edu	37	16	20563552	20563552	+	Silent	SNP	A	A	G			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr16:20563552A>G	uc002dhj.3	-	7	1018	c.808T>C	c.(808-810)TTG>CTG	p.L270L	ACSM2B_uc002dhk.3_Silent_p.L270L|ACSM2B_uc010bwf.1_Silent_p.L270L	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	270					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						AGTGAGCCCAAGATGTTCAGT	0.423000												
GTF3C1	2975	broad.mit.edu	37	16	27472881	27472881	+	Silent	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr16:27472881G>T	uc002dov.1	-	37	6160	c.6120C>A	c.(6118-6120)GGC>GGA	p.G2040G	GTF3C1_uc002dou.2_Silent_p.G2015G	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	2040						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GGGACTCCAGGCCCTGGAGAC	0.483000												
N4BP1	9683	broad.mit.edu	37	16	48594664	48594664	+	Splice_Site	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr16:48594664C>T	uc002efp.2	-	2	2126	c.1889_splice	c.e2+1	p.T630_splice		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1						negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				AATGGACTTACGTAATTGCAA	0.338000												
CDH1	999	broad.mit.edu	37	16	68847399	68847399	+	Splice_Site	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr16:68847399G>T	uc002ewg.1	+	9	1444	c.1320_splice	c.e9+1	p.K440_splice	CDH1_uc010vlj.1_Splice_Site|CDH1_uc010cfg.1_Intron	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein						adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(3)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		AACAGCAAAGGTTTGTATGGT	0.458000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
P2RX1	5023	broad.mit.edu	37	17	3802234	3802234	+	Silent	SNP	G	G	A	rs139414872		TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr17:3802234G>A	uc002fww.2	-	9	1401	c.960C>T	c.(958-960)GAC>GAT	p.D320D		NM_002558	NP_002549	P51575	P2RX1_HUMAN	purinergic receptor P2X1	320	Extracellular (Potential).				platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			ovary(1)|skin(1)	2				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		TCACCTTGCCGTCCACCAGGA	0.527000												
PLD2	5338	broad.mit.edu	37	17	4717978	4717978	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr17:4717978G>A	uc002fzc.2	+	12	1246	c.1145G>A	c.(1144-1146)AGA>AAA	p.R382K	PLD2_uc010vsj.1_Missense_Mutation_p.R239K|PLD2_uc002fzd.2_Missense_Mutation_p.R382K	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	382					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	GATGACTGGAGACTGGACATT	0.592000												
GFAP	2670	broad.mit.edu	37	17	42992568	42992568	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr17:42992568G>A	uc002ihq.2	-	1	347	c.287C>T	c.(286-288)GCG>GTG	p.A96V	GFAP_uc002ihr.2_Missense_Mutation_p.A96V|GFAP_uc010wjg.1_RNA	NM_002055	NP_002046	P14136	GFAP_HUMAN	glial fibrillary acidic protein isoform 1	96	Rod.|Coil 1A.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			ovary(1)|pancreas(1)	2		Prostate(33;0.0959)				AGCAGCCAGCGCCTTGTTTTG	0.612000												
ITGB4	3691	broad.mit.edu	37	17	73723521	73723521	+	Silent	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr17:73723521C>T	uc002jpg.2	+	4	386	c.199C>T	c.(199-201)CTG>TTG	p.L67L	ITGB4_uc002jph.2_Silent_p.L67L|ITGB4_uc010dgo.2_Silent_p.L67L|ITGB4_uc002jpi.3_Silent_p.L67L|ITGB4_uc010dgp.1_Silent_p.L67L|ITGB4_uc002jpj.2_Silent_p.L67L	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	67	PSI.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCAGGCGGAGCTGCTGGCCGC	0.672000												
MYOM1	8736	broad.mit.edu	37	18	3188900	3188900	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr18:3188900T>C	uc002klp.2	-	4	951	c.617A>G	c.(616-618)AAG>AGG	p.K206R	MYOM1_uc002klq.2_Missense_Mutation_p.K206R	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	206	5.|6 X 6 AA tandem repeats.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						CGTGGACTGCTTGGATGCTGT	0.532000												
KLHL14	57565	broad.mit.edu	37	18	30349740	30349740	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr18:30349740G>A	uc002kxm.1	-	2	1203	c.815C>T	c.(814-816)CCG>CTG	p.P272L		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	272	BACK.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						CACCAGCTCCGGGGCCGGGAT	0.637000												
EMR1	2015	broad.mit.edu	37	19	6904148	6904148	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr19:6904148C>A	uc002mfw.2	+	8	942	c.904C>A	c.(904-906)CCC>ACC	p.P302T	EMR1_uc010dvc.2_Missense_Mutation_p.P302T|EMR1_uc010dvb.2_Missense_Mutation_p.P250T|EMR1_uc010xji.1_Missense_Mutation_p.P161T|EMR1_uc010xjj.1_Intron	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	302	Extracellular (Potential).|EGF-like 6; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					AGGCTTTCATCCCAATCCAGA	0.478000												
NDUFA13	51079	broad.mit.edu	37	19	19646380	19646380	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr19:19646380G>A	uc010xqy.1	+	7	1091	c.832G>A	c.(832-834)GTA>ATA	p.V278I	YJEFN3_uc002nmt.1_Missense_Mutation_p.V196I|YJEFN3_uc010ecf.1_Missense_Mutation_p.V146I|YJEFN3_uc002nmu.1_RNA|CILP2_uc002nmv.3_5'Flank|CILP2_uc002nmw.3_5'Flank	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	GGTGGATGCCGTACTGGGCCC	0.692000												
ZNF99	7652	broad.mit.edu	37	19	22939932	22939932	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr19:22939932T>G	uc010xrh.1	-	6	2399	c.2399A>C	c.(2398-2400)AAG>ACG	p.K800T		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTGTAGGGCTTCTCCCCAGT	0.373000												
ZNF567	163081	broad.mit.edu	37	19	37203687	37203687	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr19:37203687T>G	uc010xtl.1	+	5	363	c.141T>G	c.(139-141)TGT>TGG	p.C47W	ZNF567_uc002oeo.1_Missense_Mutation_p.C47W|ZNF567_uc010xtk.1_Missense_Mutation_p.C47W|ZNF567_uc002oep.3_Missense_Mutation_p.C16W|ZNF567_uc002oeq.1_Missense_Mutation_p.C16W	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TTTCAGGGTGTCACATGACCA	0.428000												
ZNF808	388558	broad.mit.edu	37	19	53057977	53057977	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr19:53057977T>G	uc010epq.1	+	5	1985	c.1808T>G	c.(1807-1809)GTT>GGT	p.V603G	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	603	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TGTGACAAAGTTTTTGGTCAG	0.383000												
ZSCAN1	284312	broad.mit.edu	37	19	58565264	58565264	+	Missense_Mutation	SNP	C	C	T	rs144536843	byFrequency	TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr19:58565264C>T	uc002qrc.1	+	6	1319	c.1072C>T	c.(1072-1074)CGG>TGG	p.R358W		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	358					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CAAGGGCCCCCGGGAGTCCGT	0.662000												
UBE2M	9040	broad.mit.edu	37	19	59067588	59067588	+	Silent	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr19:59067588G>A	uc002qtl.3	-	6	1015	c.420C>T	c.(418-420)AAC>AAT	p.N140N	CHMP2A_uc002qti.2_5'Flank|CHMP2A_uc002qtj.2_5'Flank|CHMP2A_uc002qtk.2_5'Flank	NM_003969	NP_003960	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	140					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		GGTCCTCGGGGTTGGGCTCCT	0.612000												
RASGRP3	25780	broad.mit.edu	37	2	33748980	33748980	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr2:33748980G>T	uc002rox.2	+	9	1178	c.551G>T	c.(550-552)TGC>TTC	p.C184F	RASGRP3_uc010ync.1_Missense_Mutation_p.C184F|RASGRP3_uc002roy.2_Missense_Mutation_p.C184F	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	184	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					ATCCATGGCTGCCTGGAGAAT	0.383000												
DYSF	8291	broad.mit.edu	37	2	71744167	71744167	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr2:71744167C>T	uc002sie.2	+	9	1280	c.904C>T	c.(904-906)CGG>TGG	p.R302W	DYSF_uc010feg.2_Missense_Mutation_p.R333W|DYSF_uc010feh.2_Missense_Mutation_p.R302W|DYSF_uc002sig.3_Missense_Mutation_p.R302W|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R302W|DYSF_uc010fef.2_Missense_Mutation_p.R333W|DYSF_uc010fei.2_Missense_Mutation_p.R333W|DYSF_uc010fek.2_Missense_Mutation_p.R334W|DYSF_uc010fej.2_Missense_Mutation_p.R303W|DYSF_uc010fel.2_Missense_Mutation_p.R303W|DYSF_uc010feo.2_Missense_Mutation_p.R334W|DYSF_uc010fem.2_Missense_Mutation_p.R303W|DYSF_uc010fen.2_Missense_Mutation_p.R334W|DYSF_uc002sif.2_Missense_Mutation_p.R303W	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	302	Cytoplasmic (Potential).|C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CGGGGAGTTCCGGGTAATTGC	0.512000												
HK2	3099	broad.mit.edu	37	2	75115135	75115135	+	Silent	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr2:75115135G>A	uc002snd.2	+	16	4251	c.2325G>A	c.(2323-2325)CGG>CGA	p.R775R		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	775	Catalytic.		R -> Q.		apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						TCTCAGAGCGGCTCAAGACAA	0.498000												
CTNNA2	1496	broad.mit.edu	37	2	80101439	80101439	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr2:80101439G>A	uc010ysh.1	+	5	828	c.823G>A	c.(823-825)GAG>AAG	p.E275K	CTNNA2_uc010yse.1_Missense_Mutation_p.E275K|CTNNA2_uc010ysf.1_Missense_Mutation_p.E275K|CTNNA2_uc010ysg.1_Missense_Mutation_p.E275K	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	275					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GGGCATCGGCGAGCTGGCTGC	0.527000												
SFRS15	57466	broad.mit.edu	37	21	33068535	33068535	+	Splice_Site	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr21:33068535C>T	uc002ypd.2	-	9	1386	c.960_splice	c.e9-1	p.F320_splice	SFRS15_uc002ype.2_Splice_Site_p.F320_splice|SFRS15_uc010glu.2_Splice_Site_p.F305_splice|SFRS15_uc002ypf.1_Splice_Site	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform							nucleus	nucleotide binding|RNA binding				0						AGGAAAGCCACTAAAAAAAGG	0.403000												
CACNA1I	8911	broad.mit.edu	37	22	40015370	40015370	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr22:40015370G>A	uc003ayc.2	+	4	538	c.538G>A	c.(538-540)GTG>ATG	p.V180M	CACNA1I_uc003ayd.2_Missense_Mutation_p.V180M|CACNA1I_uc003aye.2_Missense_Mutation_p.V95M|CACNA1I_uc003ayf.2_Missense_Mutation_p.V95M	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	180	I.|Helical; Name=S4 of repeat I; (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CATCCGCACCGTGCGCGTCCT	0.612000												
BTD	686	broad.mit.edu	37	3	15686531	15686531	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr3:15686531G>T	uc003cah.2	+	4	1271	c.1168G>T	c.(1168-1170)GCT>TCT	p.A390S	BTD_uc011avv.1_Missense_Mutation_p.A392S|BTD_uc011avw.1_Missense_Mutation_p.A392S|BTD_uc011avx.1_Missense_Mutation_p.A370S	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	390					central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0						GAACGTGAATGCTCCTCCCAC	0.478000												
TGFBR2	7048	broad.mit.edu	37	3	30715619	30715619	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr3:30715619C>T	uc003ceo.2	+	5	1659	c.1277C>T	c.(1276-1278)GCT>GTT	p.A426V	TGFBR2_uc003cen.2_Missense_Mutation_p.A451V	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	426	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						AGATACATGGCTCCAGAAGTC	0.448000												
TGFBR2	7048	broad.mit.edu	37	3	30715667	30715667	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr3:30715667T>C	uc003ceo.2	+	5	1707	c.1325T>C	c.(1324-1326)TTC>TCC	p.F442S	TGFBR2_uc003cen.2_Missense_Mutation_p.F467S	NM_003242	NP_003233	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II	442	Protein kinase.|Cytoplasmic (Potential).				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			pancreas(9)|large_intestine(6)|stomach(4)|lung(3)|ovary(3)|central_nervous_system(1)	26						GTTGAGTCCTTCAAGCAGACC	0.488000												
RHOA	387	broad.mit.edu	37	3	49412898	49412898	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr3:49412898T>C	uc003cwu.2	-	2	401	c.125A>G	c.(124-126)TAT>TGT	p.Y42C	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	42	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ATCTGCCACATAGTTCTCAAA	0.433000												
CACNA1D	776	broad.mit.edu	37	3	53785816	53785816	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr3:53785816G>A	uc003dgv.3	+	28	3720	c.3557G>A	c.(3556-3558)CGG>CAG	p.R1186Q	CACNA1D_uc003dgu.3_Missense_Mutation_p.R1206Q|CACNA1D_uc003dgy.3_Missense_Mutation_p.R1186Q|CACNA1D_uc003dgw.3_Missense_Mutation_p.R853Q|CACNA1D_uc003dgx.1_Missense_Mutation_p.R334Q	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1186	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CGTCCCTTGCGGAGATACATC	0.507000												
TMEM108	66000	broad.mit.edu	37	3	133098617	133098617	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr3:133098617T>C	uc003eph.2	+	4	336	c.62T>C	c.(61-63)CTG>CCG	p.L21P	TMEM108_uc003epi.2_Missense_Mutation_p.L21P|TMEM108_uc003epj.1_Missense_Mutation_p.L21P|TMEM108_uc003epk.2_Intron|TMEM108_uc003epm.2_5'UTR	NM_023943	NP_076432	Q6UXF1	TM108_HUMAN	transmembrane protein 108 precursor	21						integral to membrane				ovary(2)|skin(2)	4						ATCTTGGCACTGACCGAAGCG	0.552000												
KIAA1211	57482	broad.mit.edu	37	4	57181091	57181091	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr4:57181091G>A	uc003hbk.2	+	8	1814	c.1423G>A	c.(1423-1425)GAT>AAT	p.D475N	KIAA1211_uc010iha.2_Missense_Mutation_p.D468N|KIAA1211_uc011bzz.1_Missense_Mutation_p.D385N|KIAA1211_uc003hbm.1_Missense_Mutation_p.D361N	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	475	Glu-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CCAGGGGGCCGATCGTCCTGG	0.632000												
SEC24D	9871	broad.mit.edu	37	4	119736228	119736228	+	Silent	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr4:119736228C>T	uc003ici.3	-	6	1028	c.756G>A	c.(754-756)CCG>CCA	p.P252P	SEC24D_uc003icj.3_Silent_p.P253P|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	252	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						GGGGCTGTGGCGGACCAGCCA	0.517000												
FGA	2243	broad.mit.edu	37	4	155506853	155506853	+	Silent	SNP	A	A	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr4:155506853A>C	uc003iod.1	-	5	1786	c.1728T>G	c.(1726-1728)TCT>TCG	p.S576S	FGA_uc003ioe.1_Silent_p.S576S|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	576	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TGTAACTTGAAGATTTACCAC	0.443000												
ADAMTS16	170690	broad.mit.edu	37	5	5242289	5242289	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr5:5242289G>A	uc003jdl.2	+	17	2785	c.2647G>A	c.(2647-2649)GTG>ATG	p.V883M	ADAMTS16_uc003jdk.1_Missense_Mutation_p.V883M	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	883	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TGAGTGCTCCGTGTCCTGCGG	0.617000												
PCDHB2	56133	broad.mit.edu	37	5	140474440	140474440	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr5:140474440G>T	uc003lil.2	+	1	204	c.66G>T	c.(64-66)TTG>TTT	p.L22F	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	22					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTTTGTTTTGCTGGGCATAG	0.537000												
C6orf201	404220	broad.mit.edu	37	6	4087935	4087935	+	Silent	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr6:4087935C>T	uc003mwa.3	+	2	828	c.60C>T	c.(58-60)CGC>CGT	p.R20R	C6orf146_uc010jnq.1_5'Flank|C6orf146_uc003mvy.2_5'Flank|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Silent_p.R20R|C6orf201_uc003mwb.3_RNA	NM_001085401	NP_001078870	Q7Z4U5	CF201_HUMAN	hypothetical protein LOC404220	20											0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TTTATTCCCGCAAGAGTGAAG	0.473000												
FRS3	10817	broad.mit.edu	37	6	41744669	41744669	+	Silent	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr6:41744669G>T	uc003orc.1	-	3	301	c.57C>A	c.(55-57)ACC>ACA	p.T19T		NM_006653	NP_006644	O43559	FRS3_HUMAN	fibroblast growth factor receptor substrate 3	19	IRS-type PTB.				fibroblast growth factor receptor signaling pathway	plasma membrane	fibroblast growth factor receptor binding|insulin receptor binding			ovary(2)	2	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCTTGAACTTGGTGGGGTGGT	0.542000												
SYNE1	23345	broad.mit.edu	37	6	152563476	152563476	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr6:152563476G>T	uc010kiw.2	-	107	20394	c.19792C>A	c.(19792-19794)CTG>ATG	p.L6598M	SYNE1_uc010kiv.2_Missense_Mutation_p.L1122M|SYNE1_uc003qos.3_Missense_Mutation_p.L1122M|SYNE1_uc003qot.3_Missense_Mutation_p.L6527M|SYNE1_uc003qou.3_Missense_Mutation_p.L6598M	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6598	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGTCAGCCAGATCTTGTAGG	0.468000										HNSCC(10;0.0054)		
OSBPL3	26031	broad.mit.edu	37	7	24874246	24874246	+	Silent	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr7:24874246G>A	uc003sxf.2	-	15	2010	c.1605C>T	c.(1603-1605)AAC>AAT	p.N535N	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Silent_p.N499N|OSBPL3_uc003sxh.2_Silent_p.N504N|OSBPL3_uc003sxi.2_Silent_p.N468N|OSBPL3_uc003sxj.1_Silent_p.N264N|OSBPL3_uc003sxk.1_Silent_p.N233N	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	535					lipid transport		lipid binding|protein binding			skin(1)	1						CCTTCCCGATGTTGTTCCTCA	0.617000												
GLI3	2737	broad.mit.edu	37	7	42011956	42011956	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr7:42011956C>T	uc011kbh.1	-	13	2174	c.2083G>A	c.(2083-2085)GTC>ATC	p.V695I	GLI3_uc011kbg.1_Missense_Mutation_p.V636I	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	695					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TCTGCCTTGACGGTTTTCACC	0.552000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
ADAM22	53616	broad.mit.edu	37	7	87564386	87564386	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr7:87564386T>C	uc003ujn.2	+	2	210	c.131T>C	c.(130-132)TTC>TCC	p.F44S	ADAM22_uc003uji.1_Missense_Mutation_p.F43S|ADAM22_uc003ujj.1_Missense_Mutation_p.F44S|ADAM22_uc003ujk.1_Missense_Mutation_p.F44S|ADAM22_uc003ujl.1_Missense_Mutation_p.F44S|ADAM22_uc003ujm.2_Missense_Mutation_p.F44S|ADAM22_uc003ujo.2_Missense_Mutation_p.F44S|ADAM22_uc003ujp.1_Missense_Mutation_p.F96S	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	44					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			GAAAACCGCTTCGTGGAGCGC	0.612000												
PTPRZ1	5803	broad.mit.edu	37	7	121652018	121652018	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr7:121652018A>C	uc003vjy.2	+	12	3313	c.2918A>C	c.(2917-2919)AAG>ACG	p.K973T	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	973	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CCAATACCTAAGTCTTCGTTA	0.443000												
DLGAP2	9228	broad.mit.edu	37	8	1513926	1513926	+	Silent	SNP	G	G	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr8:1513926G>C	uc003wpl.2	+	3	1165	c.1068G>C	c.(1066-1068)GGG>GGC	p.G356G	DLGAP2_uc003wpm.2_Silent_p.G356G	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	435					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TGAGAAGTGGGAGTTACATTA	0.557000												
BMP1	649	broad.mit.edu	37	8	22037329	22037329	+	Silent	SNP	T	T	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chr8:22037329T>C	uc003xbg.2	+	7	1192	c.948T>C	c.(946-948)CTT>CTC	p.L316L	BMP1_uc003xba.2_Silent_p.L316L|BMP1_uc003xbb.2_Silent_p.L316L|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_Silent_p.L65L|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_Silent_p.L65L|BMP1_uc011kzc.1_Silent_p.L65L|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	316	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		CCCGCAAGCTTTACAAGTGCC	0.612000												
P2RY8	286530	broad.mit.edu	37	X	1584583	1584583	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:1584583G>A	uc004cpz.2	-	2	1117	c.869C>T	c.(868-870)CCG>CTG	p.P290L		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	290	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATAAACAAACGGGTCCAGACA	0.602000			T	CRLF2	B-ALL|Downs associated ALL							
MSL3	10943	broad.mit.edu	37	X	11793170	11793170	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:11793170G>A	uc004cuw.2	+	13	1643	c.1538G>A	c.(1537-1539)AGC>AAC	p.S513N	MSL3_uc004cux.2_Missense_Mutation_p.S454N|MSL3_uc011mig.1_Missense_Mutation_p.S364N|MSL3_uc011mih.1_Missense_Mutation_p.S501N|MSL3_uc004cuy.2_Missense_Mutation_p.S347N	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	513					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCACATTACAGCACCAAGAAC	0.453000												
CDKL5	6792	broad.mit.edu	37	X	18643268	18643268	+	Silent	SNP	T	T	C			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:18643268T>C	uc004cym.2	+	17	2650	c.2397T>C	c.(2395-2397)CCT>CCC	p.P799P	CDKL5_uc004cyn.2_Silent_p.P799P	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	799					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					CCGACAGCCCTGATCTTCTGA	0.478000												
KLHL34	257240	broad.mit.edu	37	X	21674200	21674200	+	Silent	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:21674200G>A	uc004czz.1	-	1	2249	c.1707C>T	c.(1705-1707)GTC>GTT	p.V569V		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	569	Kelch 5.									ovary(1)	1						CTGTCTCCTCGACCACGGCCA	0.682000												
MAGEB3	4114	broad.mit.edu	37	X	30254217	30254217	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:30254217G>A	uc004dca.1	+	5	913	c.176G>A	c.(175-177)CGT>CAT	p.R59H		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	59											0						GGTAGGTCACGTAGTGCTCTC	0.428000												
FAM120C	54954	broad.mit.edu	37	X	54161998	54161998	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:54161998C>T	uc004dsz.3	-	6	1381	c.1298G>A	c.(1297-1299)CGA>CAA	p.R433Q	FAM120C_uc011moh.1_Missense_Mutation_p.R433Q	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	433										ovary(1)|central_nervous_system(1)	2						CACTTGATTTCGTGGAAGGGG	0.393000												
MAGEE1	57692	broad.mit.edu	37	X	75650723	75650723	+	Silent	SNP	A	A	G			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:75650723A>G	uc004ecm.1	+	1	2607	c.2400A>G	c.(2398-2400)ACA>ACG	p.T800T		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	800	Interaction with DTNA (By similarity).|MAGE 2.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						TCTATGGGACAGAACTAGTGG	0.498000												
ZCCHC5	203430	broad.mit.edu	37	X	77912593	77912593	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:77912593C>T	uc004edc.1	-	2	1621	c.1325G>A	c.(1324-1326)GGC>GAC	p.G442D		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	442							nucleic acid binding|zinc ion binding			ovary(1)	1						GCATAAGCGGCCTTTGTGCCA	0.557000												
COL4A6	1288	broad.mit.edu	37	X	107431078	107431078	+	Silent	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:107431078C>T	uc004enw.3	-	22	1873	c.1770G>A	c.(1768-1770)CCG>CCA	p.P590P	COL4A6_uc004env.3_Silent_p.P589P|COL4A6_uc011msn.1_Silent_p.P589P|COL4A6_uc010npk.2_Silent_p.P589P	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	590	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						ATCAACTTACCGGAAGGCCTG	0.537000									Alport_syndrome_with_Diffuse_Leiomyomatosis			
IL13RA1	3597	broad.mit.edu	37	X	117895118	117895118	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:117895118C>T	uc004eqs.2	+	6	737	c.694C>T	c.(694-696)CAT>TAT	p.H232Y	IL13RA1_uc004eqr.1_Missense_Mutation_p.H232Y|IL13RA1_uc004eqt.1_Missense_Mutation_p.H232Y	NM_001560	NP_001551	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1 precursor	232	Extracellular (Potential).					interleukin-13 receptor complex	cytokine receptor activity				0						TGATCCTCCACATATTAAAAA	0.308000												
SAGE1	55511	broad.mit.edu	37	X	134989523	134989523	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6522-01A-11D-1800-08	TCGA-D7-6522-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4724ddc-1714-41ed-8d34-d1e7210f4776	94057bd1-d097-442e-ac82-0d54e3f678eb	g.chrX:134989523C>T	uc004ezh.2	+	9	1096	c.929C>T	c.(928-930)CCG>CTG	p.P310L	SAGE1_uc010nry.1_Missense_Mutation_p.P279L|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	310										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AATGACCAACCGCAACCTAAT	0.413000