Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
SLC2A7	155184	broad.mit.edu	37	1	9082993	9082993	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:9082993C>T	uc009vmo.1	-	3	295	c.295G>A	c.(295-297)GTT>ATT	p.V99I		NM_207420	NP_997303	Q6PXP3	GTR7_HUMAN	intestinal facilitative glucose transporter 7	99	Helical; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CAGCTATCAACCAGCAGGCCC	0.512000												
DFFA	1676	broad.mit.edu	37	1	10527274	10527274	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:10527274G>A	uc001arj.2	-	3	512	c.414C>T	c.(412-414)ATC>ATT	p.I138I	DFFA_uc001ark.2_Silent_p.I138I	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	138					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		ATAGGAGGATGATGCTGGACA	0.537000												
PRAMEF12	390999	broad.mit.edu	37	1	12837237	12837237	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:12837237C>T	uc001aui.2	+	3	974	c.947C>T	c.(946-948)CCG>CTG	p.P316L		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	316										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCTTGGTGCCCGAGCATCCGT	0.567000												
AIM1L	55057	broad.mit.edu	37	1	26655305	26655305	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:26655305G>A	uc001bmd.3	-	15	1669	c.1239C>T	c.(1237-1239)ATC>ATT	p.I413I		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	413	Beta/gamma crystallin 'Greek key' 9.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		TGCTGAGCTCGATCTCCTTCC	0.597000												
CELSR2	1952	broad.mit.edu	37	1	109793708	109793708	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:109793708C>T	uc001dxa.3	+	1	1068	c.1007C>T	c.(1006-1008)CCC>CTC	p.P336L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	336	Cadherin 2.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GGGGGCAGCCCCTCTGAAGTC	0.607000												
TRIM33	51592	broad.mit.edu	37	1	114940396	114940396	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:114940396G>A	uc001eew.2	-	20	3342	c.3258C>T	c.(3256-3258)TTC>TTT	p.F1086F	TRIM33_uc010owr.1_Silent_p.F700F|TRIM33_uc010ows.1_Silent_p.F718F|TRIM33_uc001eex.2_Silent_p.F1069F	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	1086					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCAAAGGTGCGAAGGTCCTGT	0.468000			T	RET	papillary thyroid							
CD1E	913	broad.mit.edu	37	1	158325888	158325888	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:158325888C>G	uc001fse.2	+	4	1136	c.897C>G	c.(895-897)ATC>ATG	p.I299M	CD1E_uc010pid.1_Missense_Mutation_p.I297M|CD1E_uc010pie.1_Missense_Mutation_p.I200M|CD1E_uc010pif.1_Missense_Mutation_p.I110M|CD1E_uc001fsd.2_Intron|CD1E_uc001fsk.2_Missense_Mutation_p.I209M|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Missense_Mutation_p.I110M|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.I299M|CD1E_uc001fry.2_Intron|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Missense_Mutation_p.I110M|CD1E_uc001fsi.2_Intron|CD1E_uc009wsv.2_Missense_Mutation_p.I200M|CD1E_uc001frz.2_Missense_Mutation_p.I209M|CD1E_uc009wsw.2_Missense_Mutation_p.I57M	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	299	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					ATCTAATCATCCATTGGGGTG	0.547000												
TNFSF4	7292	broad.mit.edu	37	1	173157667	173157667	+	Silent	SNP	T	T	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:173157667T>C	uc001giw.2	-	2	351	c.195A>G	c.(193-195)CAA>CAG	p.Q65Q	TNFSF4_uc001giv.2_Silent_p.Q15Q	NM_003326	NP_003317	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily,	65	Extracellular (Potential).				acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			central_nervous_system(1)	1						TACCGGTAAATTGTACTTTGA	0.318000												
CHI3L1	1116	broad.mit.edu	37	1	203152776	203152776	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:203152776A>G	uc001gzi.2	-	5	629	c.458T>C	c.(457-459)CTA>CCA	p.L153P	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_5'Flank|CHI3L1_uc001gzj.2_Missense_Mutation_p.L153P	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	153					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1						CACCTTGATTAGGGTGGTAAA	0.587000												
NFASC	23114	broad.mit.edu	37	1	204966334	204966334	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:204966334C>T	uc001hbj.2	+	25	3147	c.2819C>T	c.(2818-2820)ACG>ATG	p.T940M	NFASC_uc010pra.1_Intron|NFASC_uc001hbi.2_Intron|NFASC_uc010prb.1_Intron|NFASC_uc010prc.1_Intron|NFASC_uc001hbl.1_Intron|NFASC_uc001hbm.1_Intron|NFASC_uc001hbn.1_Missense_Mutation_p.T86M|NFASC_uc009xbh.1_Translation_Start_Site	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	997	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GTGGGTGCGACGGGCGCTGTG	0.557000												
MARK1	4139	broad.mit.edu	37	1	220824034	220824034	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:220824034G>A	uc001hmn.3	+	14	2140	c.1543G>A	c.(1543-1545)GTA>ATA	p.V515I	MARK1_uc009xdw.2_Missense_Mutation_p.V515I|MARK1_uc010pun.1_Missense_Mutation_p.V515I|MARK1_uc001hmm.3_Missense_Mutation_p.V493I	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	515					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		AGATCGATACGTAGCATTGCA	0.408000												
KIAA1383	54627	broad.mit.edu	37	1	232942122	232942122	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:232942122G>T	uc001hvh.2	+	1	1485	c.1353G>T	c.(1351-1353)TTG>TTT	p.L451F		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	309										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				ACACTAACTTGACCCAAGAAA	0.443000												
NID1	4811	broad.mit.edu	37	1	236142365	236142365	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:236142365C>T	uc001hxo.2	-	19	3654	c.3552G>A	c.(3550-3552)ACG>ACA	p.T1184T	NID1_uc009xgd.2_Silent_p.T1051T|NID1_uc009xgc.2_Silent_p.T265T	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	1184					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GGAAAGCATCCGTCTCCTTGG	0.507000												
FMN2	56776	broad.mit.edu	37	1	240256644	240256644	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:240256644C>T	uc010pyd.1	+	1	1460	c.1235C>T	c.(1234-1236)CCG>CTG	p.P412L	FMN2_uc010pye.1_Missense_Mutation_p.P412L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	412					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AAGCCCTACCCGCTCATCACC	0.677000												
OR2L13	284521	broad.mit.edu	37	1	248263077	248263077	+	Missense_Mutation	SNP	C	C	T	rs147060080		TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr1:248263077C>T	uc001ids.2	+	3	737	c.400C>T	c.(400-402)CGC>TGC	p.R134C		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TTATCCTATCCGCATGAGTAA	0.488000												
CNNM1	26507	broad.mit.edu	37	10	101124191	101124191	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr10:101124191G>A	uc001kpp.3	+	5	2335	c.2046G>A	c.(2044-2046)GAG>GAA	p.E682E	CNNM1_uc009xwe.2_Silent_p.E682E|CNNM1_uc010qpi.1_Silent_p.E682E|CNNM1_uc009xwf.2_Silent_p.E682E|CNNM1_uc009xwg.2_Silent_p.E82E	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	682					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		TGGAGGTGGAGGTTGGTAAGG	0.423000												
DENND5A	23258	broad.mit.edu	37	11	9192306	9192306	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr11:9192306C>T	uc001mhl.2	-	9	2180	c.1925G>A	c.(1924-1926)CGT>CAT	p.R642H	DENND5A_uc001mhk.2_5'UTR|DENND5A_uc010rbw.1_Missense_Mutation_p.R642H|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	642										liver(1)	1						TTTTGCCAGACGCAGCTCAAT	0.318000												
DSCAML1	57453	broad.mit.edu	37	11	117307909	117307909	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr11:117307909C>T	uc001prh.1	-	26	4831	c.4829G>A	c.(4828-4830)CGC>CAC	p.R1610H		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1550	Extracellular (Potential).|Fibronectin type-III 6.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGCCCTCATGCGCAGCTCGTA	0.647000												
PDE3A	5139	broad.mit.edu	37	12	20769164	20769164	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:20769164C>T	uc001reh.1	+	4	1292	c.1270C>T	c.(1270-1272)CGC>TGC	p.R424C		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	424					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TCTTTCCTAGCGCCTGAGAAG	0.428000												
LRRK2	120892	broad.mit.edu	37	12	40697868	40697868	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:40697868T>G	uc001rmg.3	+	27	3830	c.3709T>G	c.(3709-3711)TTG>GTG	p.L1237V	LRRK2_uc001rmh.1_Missense_Mutation_p.L859V|LRRK2_uc009zjw.2_Missense_Mutation_p.L75V|LRRK2_uc001rmi.2_Missense_Mutation_p.L70V	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1237	LRR 10.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CATCTTGGACTTGAGTGAAAA	0.373000												
ZBTB39	9880	broad.mit.edu	37	12	57398420	57398420	+	Silent	SNP	T	T	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:57398420T>C	uc001sml.1	-	2	368	c.282A>G	c.(280-282)ACA>ACG	p.T94T	RDH16_uc010sqx.1_5'Flank	NM_014830	NP_055645	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	94	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						TGATCAGGTCTGTGAAGAGTT	0.517000												
CAND1	55832	broad.mit.edu	37	12	67699937	67699937	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:67699937C>G	uc001stn.2	+	10	2926	c.2489C>G	c.(2488-2490)TCT>TGT	p.S830C	CAND1_uc001sto.2_Missense_Mutation_p.S340C	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	830	HEAT 19.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		AACTCAAGGTCTACAGATTCC	0.413000												
NT5DC3	51559	broad.mit.edu	37	12	104192371	104192371	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:104192371G>A	uc010swe.1	-	5	650	c.609C>T	c.(607-609)TAC>TAT	p.Y203Y		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	203							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						TTACCTTTCCGTAAAAGTCAC	0.438000												
RIC8B	55188	broad.mit.edu	37	12	107209073	107209073	+	Silent	SNP	G	G	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:107209073G>T	uc001tlx.2	+	3	857	c.732G>T	c.(730-732)GTG>GTT	p.V244V	RIC8B_uc001tlw.2_Silent_p.V244V|RIC8B_uc001tly.2_Silent_p.V204V|RIC8B_uc001tlz.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	244					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						GTTGGAAGGTGCATAAAGAGG	0.423000												
PRDM4	11108	broad.mit.edu	37	12	108134886	108134886	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:108134886T>G	uc001tmp.2	-	10	2198	c.1761A>C	c.(1759-1761)GAA>GAC	p.E587D	PRDM4_uc010sww.1_5'UTR|PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	587					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TCCACTTCCTTTCTTTGCTGT	0.493000												
SBNO1	55206	broad.mit.edu	37	12	123829886	123829886	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:123829886G>C	uc010tap.1	-	3	469	c.469C>G	c.(469-471)CTA>GTA	p.L157V	SBNO1_uc010tao.1_Missense_Mutation_p.L156V|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.L157V|SBNO1_uc001ueu.2_Missense_Mutation_p.L156V|SBNO1_uc001uev.2_Missense_Mutation_p.L155V|SBNO1_uc009zxy.1_Missense_Mutation_p.L122V	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	157							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TTTTTCAGTAGATCTTTAAGC	0.423000												
ALOX5AP	241	broad.mit.edu	37	13	31326239	31326239	+	Missense_Mutation	SNP	C	C	T	rs148308449		TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr13:31326239C>T	uc001utf.1	+	3	295	c.221C>T	c.(220-222)GCG>GTG	p.A74V	ALOX5AP_uc010tdr.1_Missense_Mutation_p.A131V	NM_001629	NP_001620	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	74	Helical.				cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding				0		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		CTCTGGTCTGCGGGGCTACTT	0.463000												
KBTBD6	89890	broad.mit.edu	37	13	41705946	41705946	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr13:41705946C>G	uc001uxu.1	-	1	991	c.702G>C	c.(700-702)GAG>GAC	p.E234D	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.E168D|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	234							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		TCTGCTCACTCTCCACGTCCA	0.597000												
EDNRB	1910	broad.mit.edu	37	13	78492238	78492238	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr13:78492238G>A	uc001vko.2	-	1	729	c.471C>T	c.(469-471)ATC>ATT	p.I157I	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Silent_p.I157I|EDNRB_uc010aez.1_Silent_p.I157I|EDNRB_uc001vkp.1_Silent_p.I240I|EDNRB_uc010afa.1_Silent_p.I157I	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	157	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	TGTAGACATTGATAGGGATGT	0.512000												
TPP2	7174	broad.mit.edu	37	13	103295620	103295620	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr13:103295620T>G	uc001vpi.3	+	17	2172	c.2069T>G	c.(2068-2070)CTA>CGA	p.L690R		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	690					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAGTTTGTTCTACATGCAGTC	0.373000												
KIAA1409	57578	broad.mit.edu	37	14	94053116	94053116	+	Missense_Mutation	SNP	A	A	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr14:94053116A>C	uc001ybv.1	+	19	2446	c.2363A>C	c.(2362-2364)AAG>ACG	p.K788T	KIAA1409_uc001ybs.1_Missense_Mutation_p.K788T	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	965						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GAAATGGCTAAGTTTGAAGAG	0.358000												
FANCI	55215	broad.mit.edu	37	15	89837116	89837116	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr15:89837116T>G	uc010bnp.1	+	23	2434	c.2344T>G	c.(2344-2346)TCT>GCT	p.S782A	FANCI_uc002bnm.1_Missense_Mutation_p.S782A|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.S603A|FANCI_uc002bnq.1_Missense_Mutation_p.S195A	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	782					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CAAAAAACTCTCTGACATTCT	0.348000								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia			
WDR90	197335	broad.mit.edu	37	16	701703	701703	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr16:701703C>T	uc002cii.1	+	8	850	c.796C>T	c.(796-798)CGG>TGG	p.R266W	WDR90_uc002cig.1_Missense_Mutation_p.R266W|WDR90_uc002cih.1_Missense_Mutation_p.R266W|WDR90_uc002cij.1_RNA	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	266										ovary(1)	1		Hepatocellular(780;0.0218)				CAAACCTGTGCGGTTCAGTGT	0.652000												
ATP2A1	487	broad.mit.edu	37	16	28909608	28909608	+	Silent	SNP	C	C	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr16:28909608C>A	uc002dro.1	+	14	1784	c.1600C>A	c.(1600-1602)CGG>AGG	p.R534R	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.R534R|ATP2A1_uc002drp.1_Silent_p.R409R	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	534	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGGCACCACCCGGGTGCCACT	0.632000												
PHKG2	5261	broad.mit.edu	37	16	30768315	30768315	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr16:30768315T>C	uc002dzk.1	+	10	1211	c.1118T>C	c.(1117-1119)CTC>CCC	p.L373P	PHKG2_uc002dzi.1_Missense_Mutation_p.L377P|PHKG2_uc002dzj.1_Missense_Mutation_p.L271P	NM_000294	NP_000285	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	373					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)	1			Colorectal(24;0.198)			CGGGCGGCTCTCTTTCAGCAC	0.617000												
CDH1	999	broad.mit.edu	37	16	68845623	68845623	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr16:68845623A>G	uc002ewg.1	+	7	993	c.869A>G	c.(868-870)GAC>GGC	p.D290G	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.D290G	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	290	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		ACAGACGCGGACGATGATGTG	0.493000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
INCA1	388324	broad.mit.edu	37	17	4891775	4891775	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:4891775C>T	uc002gaj.2	-	8	1088	c.636G>A	c.(634-636)TCG>TCA	p.S212S	CAMTA2_uc010cku.1_5'Flank|CAMTA2_uc002gag.1_5'Flank|CAMTA2_uc002gah.1_5'Flank|CAMTA2_uc002gai.1_5'Flank|CAMTA2_uc010vsu.1_5'Flank|INCA1_uc002gak.2_Silent_p.S212S|INCA1_uc002gal.2_Silent_p.S197S|INCA1_uc002gam.2_Silent_p.S197S	NM_213726	NP_998891	Q0VD86	INCA1_HUMAN	inhibitor of CDK, cyclin A1 interacting protein	212						nucleus					0						CAGTGCTGAACGAGGCCAGAG	0.567000												
TP53	7157	broad.mit.edu	37	17	7578407	7578407	+	Missense_Mutation	SNP	G	G	C	rs138729528		TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:7578407G>C	uc002gim.2	-	5	717	c.523C>G	c.(523-525)CGC>GGC	p.R175G	TP53_uc002gig.1_Missense_Mutation_p.R175G|TP53_uc002gih.2_Missense_Mutation_p.R175G|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43G|TP53_uc010cng.1_Missense_Mutation_p.R43G|TP53_uc002gii.1_Missense_Mutation_p.R43G|TP53_uc010cnh.1_Missense_Mutation_p.R175G|TP53_uc010cni.1_Missense_Mutation_p.R175G|TP53_uc002gij.2_Missense_Mutation_p.R175G|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82G|TP53_uc002gio.2_Missense_Mutation_p.R43G|TP53_uc010vug.1_Missense_Mutation_p.R136G	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(721)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.S149fs*72(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGGGGCAGCGCCTCACAACC	0.657000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
MFSD6L	162387	broad.mit.edu	37	17	8701689	8701689	+	Missense_Mutation	SNP	C	C	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:8701689C>G	uc002glp.1	-	1	898	c.750G>C	c.(748-750)TTG>TTC	p.L250F		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	250	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						CCACGGACCCCAAGGAGAGGA	0.577000												
MYH13	8735	broad.mit.edu	37	17	10219280	10219280	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:10219280G>A	uc002gmk.1	-	28	3891	c.3801C>T	c.(3799-3801)GAC>GAT	p.D1267D		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1267	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TCTGTTGCTCGTCCTTGGCTT	0.463000												
ZNF286A	57335	broad.mit.edu	37	17	15604534	15604534	+	Missense_Mutation	SNP	C	C	T	rs145330416	byFrequency	TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:15604534C>T	uc010cot.2	+	3	502	c.106C>T	c.(106-108)CGC>TGC	p.R36C	ZNF286A_uc002goz.3_5'UTR|ZNF286A_uc010vwa.1_Missense_Mutation_p.R36C|ZNF286A_uc002gpa.2_Missense_Mutation_p.R36C	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	36					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		GGCTGCTCTGCGCCTCACGGC	0.483000												
UTP6	55813	broad.mit.edu	37	17	30190407	30190407	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:30190407G>A	uc002hgr.2	-	19	1848	c.1765C>T	c.(1765-1767)CAT>TAT	p.H589Y	UTP6_uc002hgq.2_Missense_Mutation_p.H405Y|UTP6_uc010cst.2_Missense_Mutation_p.H438Y	NM_018428	NP_060898	Q9NYH9	UTP6_HUMAN	hepatocellular carcinoma-associated antigen 66	589					rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				TGCATAGCATGTTTAGCTACA	0.453000												
ACCN1	40	broad.mit.edu	37	17	32483077	32483077	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:32483077G>A	uc002hhu.2	-	1	749	c.475C>T	c.(475-477)CGT>TGT	p.R159C		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	159	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	TGGCCCACACGGTGCAGGAAC	0.567000												
CDC6	990	broad.mit.edu	37	17	38447833	38447833	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:38447833T>A	uc002huj.1	+	4	783	c.573T>A	c.(571-573)TGT>TGA	p.C191*		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	191					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						AACACATCTGTGGGAAAAAAG	0.502000												
ANKRD40	91369	broad.mit.edu	37	17	48776919	48776919	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:48776919G>A	uc002iso.2	-	3	874	c.619C>T	c.(619-621)CCT>TCT	p.P207S		NM_052855	NP_443087	Q6AI12	ANR40_HUMAN	ankyrin repeat domain 40	207	Pro-rich.										0			BRCA - Breast invasive adenocarcinoma(22;2.03e-09)			TGACAAACAGGACCCGGTTTT	0.552000												
BPTF	2186	broad.mit.edu	37	17	65919031	65919031	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:65919031C>A	uc002jgf.2	+	14	5694	c.5633C>A	c.(5632-5634)ACT>AAT	p.T1878N	BPTF_uc002jge.2_Missense_Mutation_p.T2004N	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	2004					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CCCAAGCAAACTGGCCCTGTT	0.463000												
SSTR2	6752	broad.mit.edu	37	17	71166520	71166520	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr17:71166520G>A	uc002jje.2	+	2	1422	c.1062G>A	c.(1060-1062)ACG>ACA	p.T354T		NM_001050	NP_001041	P30874	SSR2_HUMAN	somatostatin receptor 2	354	Cytoplasmic (Potential).				digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity				0			LUSC - Lung squamous cell carcinoma(166;0.197)			ATGAGACCACGGAGACCCAGA	0.552000												
LAMA1	284217	broad.mit.edu	37	18	7080074	7080074	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr18:7080074A>T	uc002knm.2	-	3	339	c.245T>A	c.(244-246)ATA>AAA	p.I82K	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	82	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCATGTGATATTGGATGGCG	0.398000												
KIAA1012	22878	broad.mit.edu	37	18	29435730	29435730	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr18:29435730G>A	uc002kxc.3	-	21	3593	c.3229C>T	c.(3229-3231)CGG>TGG	p.R1077W	KIAA1012_uc002kxb.3_Missense_Mutation_p.R1023W|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1077					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTTAAAGACCGACTGGTACAA	0.353000												
ZNF236	7776	broad.mit.edu	37	18	74607109	74607109	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr18:74607109G>A	uc002lmi.2	+	10	1750	c.1552G>A	c.(1552-1554)GCC>ACC	p.A518T	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	518	C2H2-type 11.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GTGCTTCCGCGCCTTCGCCGT	0.617000												
ATP9B	374868	broad.mit.edu	37	18	76936846	76936846	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr18:76936846G>A	uc002lmx.2	+	8	826	c.812G>A	c.(811-813)GGT>GAT	p.G271D	ATP9B_uc002lmv.1_Intron|ATP9B_uc002lmw.1_Missense_Mutation_p.G271D|ATP9B_uc002lmy.1_Intron|ATP9B_uc002lmz.1_Translation_Start_Site	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	271	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CAACTAGATGGTGAAACTGAC	0.453000												
ZNF557	79230	broad.mit.edu	37	19	7081985	7081985	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:7081985G>A	uc002mgb.2	+	7	812	c.327G>A	c.(325-327)GTG>GTA	p.V109V	ZNF557_uc002mga.2_Silent_p.V116V|ZNF557_uc002mgc.2_Silent_p.V116V	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		TTTCAGATGTGGAGAATCCAT	0.328000												
ZNF317	57693	broad.mit.edu	37	19	9271728	9271728	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:9271728G>A	uc002mku.2	+	7	1682	c.1407G>A	c.(1405-1407)ACG>ACA	p.T469T	ZNF317_uc002mkv.2_Silent_p.T328T|ZNF317_uc002mkw.2_Silent_p.T437T|ZNF317_uc002mkx.2_Silent_p.T384T|ZNF317_uc002mky.2_Silent_p.T352T	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGATACACACGCAAGAGAGAC	0.532000												
SLC1A6	6511	broad.mit.edu	37	19	15063868	15063868	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:15063868C>T	uc002naa.1	-	8	1379	c.1371G>A	c.(1369-1371)ACG>ACA	p.T457T	SLC1A6_uc010dzu.1_Silent_p.T379T|SLC1A6_uc010xod.1_Silent_p.T393T	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	457					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	CTGCTGTGGCCGTGATGCTGC	0.363000												
ZNF599	148103	broad.mit.edu	37	19	35251150	35251150	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:35251150G>T	uc010edn.1	-	4	944	c.556C>A	c.(556-558)CCA>ACA	p.P186T	ZNF599_uc010edm.1_Missense_Mutation_p.P149T	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TCTTTTCCTGGTCCTTGAGAG	0.473000												
HIPK4	147746	broad.mit.edu	37	19	40886895	40886895	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:40886895G>A	uc002onp.2	-	3	1288	c.1003C>T	c.(1003-1005)CGC>TGC	p.R335C		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	335	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GGGCTGATGCGTTCGTGTGAC	0.652000												
SCAF1	58506	broad.mit.edu	37	19	50149863	50149863	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:50149863C>T	uc002poq.2	+	5	466	c.342C>T	c.(340-342)CGC>CGT	p.R114R		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	114					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TTCCCAGCCGCCTGGACCTGC	0.667000												
ZNF578	147660	broad.mit.edu	37	19	53014862	53014862	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:53014862C>A	uc002pzp.3	+	6	1472	c.1228C>A	c.(1228-1230)CAA>AAA	p.Q410K		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	185	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		GGCTTTTAATCAACAATCACA	0.383000												
ZNF600	162966	broad.mit.edu	37	19	53268973	53268973	+	Nonsense_Mutation	SNP	G	G	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:53268973G>C	uc002qab.3	-	3	2322	c.2036C>G	c.(2035-2037)TCA>TGA	p.S679*		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	679	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		TTTCAGGTGTGAATCACTCCC	0.398000												
ZNF582	147948	broad.mit.edu	37	19	56901826	56901826	+	Missense_Mutation	SNP	T	T	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:56901826T>G	uc002qmz.1	-	3	213	c.54A>C	c.(52-54)GAA>GAC	p.E18D	ZNF582_uc002qmy.2_Missense_Mutation_p.E49D	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	18	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		ACTGCCATTCTTCTTGGGAGA	0.478000												
ZNF416	55659	broad.mit.edu	37	19	58083815	58083815	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:58083815C>A	uc002qpf.2	-	4	1628	c.1457G>T	c.(1456-1458)AGA>ATA	p.R486I	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	486	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		AGTGTGAGTTCTCTGGTGCCT	0.403000												
ZNF417	147687	broad.mit.edu	37	19	58420743	58420743	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr19:58420743G>A	uc002qqq.2	-	3	1102	c.903C>T	c.(901-903)TGC>TGT	p.C301C	ZNF417_uc010yhm.1_Silent_p.C258C|ZNF417_uc002qqr.2_Silent_p.C300C	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	301	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		AAGATTTCCCGCACTCCTCAC	0.453000												
PLEK	5341	broad.mit.edu	37	2	68613709	68613709	+	Missense_Mutation	SNP	C	C	T	rs148824923		TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr2:68613709C>T	uc002sen.3	+	5	710	c.548C>T	c.(547-549)TCG>TTG	p.S183L	PLEK_uc010fde.2_Missense_Mutation_p.S183L	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	183	DEP.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		ATTGCTTCATCGCTGCTCAAT	0.527000												
ZEB2	9839	broad.mit.edu	37	2	145274864	145274864	+	Silent	SNP	G	G	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr2:145274864G>T	uc002tvu.2	-	2	534	c.54C>A	c.(52-54)GCC>GCA	p.A18A	ZEB2_uc002tvv.2_Silent_p.A13A|ZEB2_uc010zbm.1_Silent_p.A13A|ZEB2_uc010fnp.2_Silent_p.A13A|ZEB2_uc010fnq.1_Silent_p.A47A|ZEB2_uc002tvw.2_Silent_p.A13A|ZEB2_uc002tvx.1_RNA|ZEB2_uc002tvy.2_Silent_p.A47A|ZEB2_uc002tvz.2_RNA|ZEB2_uc002twa.2_RNA	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	18						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCCTGGGATTGGCTTGTTTGC	0.592000												
ABCB11	8647	broad.mit.edu	37	2	169791908	169791908	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr2:169791908G>A	uc002ueo.1	-	23	2968	c.2842C>T	c.(2842-2844)CGC>TGC	p.R948C	ABCB11_uc010zda.1_Missense_Mutation_p.R390C|ABCB11_uc010zdb.1_Missense_Mutation_p.R424C	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	948	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GCAACAGTGCGGATGTTACTG	0.438000												
SPAG16	79582	broad.mit.edu	37	2	214727351	214727351	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr2:214727351A>G	uc002veq.2	+	11	1305	c.1213A>G	c.(1213-1215)AGT>GGT	p.S405G	SPAG16_uc010fuz.1_Missense_Mutation_p.S256G|SPAG16_uc002ver.2_Missense_Mutation_p.S351G|SPAG16_uc010zjk.1_Missense_Mutation_p.S311G	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	405	WD 2.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTTCCATCCCAGGTCAGTGCA	0.498000												
CXCR1	3577	broad.mit.edu	37	2	219029327	219029327	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr2:219029327C>T	uc002vhc.2	-	2	727	c.608G>A	c.(607-609)CGG>CAG	p.R203Q		NM_000634	NP_000625	P25024	CXCR1_HUMAN	interleukin 8 receptor alpha	203	Helical; Name=5; (Potential).				dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			lung(2)	2						AGGCAGGATCCGCAACACCAT	0.522000												
COL4A4	1286	broad.mit.edu	37	2	227875130	227875130	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr2:227875130G>A	uc010zlt.1	-	45	5075	c.4421C>T	c.(4420-4422)ACG>ATG	p.T1474M		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1474	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CTCCTGGTCCGTCTGACTGTG	0.587000												
HDLBP	3069	broad.mit.edu	37	2	242196205	242196205	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr2:242196205G>A	uc002waz.2	-	6	695	c.467C>T	c.(466-468)GCC>GTC	p.A156V	HDLBP_uc002wba.2_Missense_Mutation_p.A156V|HDLBP_uc002wbb.2_Missense_Mutation_p.A177V|HDLBP_uc010fzn.1_5'UTR	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	156					cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TTTGGGAATGGCAACAGTTGC	0.378000												
TASP1	55617	broad.mit.edu	37	20	13415717	13415717	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr20:13415717G>A	uc002woi.2	-	12	1187	c.1070C>T	c.(1069-1071)TCC>TTC	p.S357F	TASP1_uc010zri.1_RNA|TASP1_uc002woh.2_Missense_Mutation_p.S334F	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	357				S -> F (in Ref. 1; BAA91018).	asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						ATTTTGGGAGGAGTCAGGCTC	0.423000												
DNMT3B	1789	broad.mit.edu	37	20	31394056	31394056	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr20:31394056C>T	uc002wyc.2	+	22	2664	c.2343C>T	c.(2341-2343)ATC>ATT	p.I781I	DNMT3B_uc002wyd.2_Silent_p.I761I|DNMT3B_uc002wye.2_Intron|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_Intron|DNMT3B_uc010ztz.1_Intron|DNMT3B_uc010zua.1_Intron|DNMT3B_uc002wyf.2_Silent_p.I773I|DNMT3B_uc002wyg.2_Intron|DNMT3B_uc010geg.2_Intron|DNMT3B_uc010geh.2_RNA	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	781					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						CGAACTCGATCAAACAGGGGA	0.453000												
C20orf152	140894	broad.mit.edu	37	20	34563887	34563887	+	Missense_Mutation	SNP	G	G	A	rs138922540		TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr20:34563887G>A	uc002xes.1	+	3	362	c.206G>A	c.(205-207)CGA>CAA	p.R69Q	C20orf152_uc002xer.1_Missense_Mutation_p.R69Q|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	69											0	Breast(12;0.00631)					ATGCAAAGCCGAGTCACATTT	0.448000												
CTCFL	140690	broad.mit.edu	37	20	56098150	56098150	+	Missense_Mutation	SNP	G	G	C	rs139237396	byFrequency	TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr20:56098150G>C	uc010gix.1	-	2	1390	c.728C>G	c.(727-729)TCT>TGT	p.S243C	CTCFL_uc010giw.1_Missense_Mutation_p.S243C|CTCFL_uc002xym.2_Missense_Mutation_p.S243C|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Missense_Mutation_p.S243C|CTCFL_uc010gjb.1_Missense_Mutation_p.S243C|CTCFL_uc010gjc.1_Missense_Mutation_p.S243C|CTCFL_uc010gjd.1_Missense_Mutation_p.S243C|CTCFL_uc010gje.2_Missense_Mutation_p.S243C|CTCFL_uc010gjf.2_Missense_Mutation_p.S38C|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Missense_Mutation_p.S243C|CTCFL_uc010gji.1_Missense_Mutation_p.S38C|CTCFL_uc010gjj.1_Missense_Mutation_p.S243C|CTCFL_uc010gjk.1_Missense_Mutation_p.S243C|CTCFL_uc010gjl.1_Missense_Mutation_p.S243C	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	243					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			ATTTTTTGTAGATTTGGCCTT	0.403000												
RASD2	23551	broad.mit.edu	37	22	35947662	35947662	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr22:35947662G>T	uc003anx.2	+	3	589	c.384G>T	c.(382-384)AAG>AAT	p.K128N	RASD2_uc003any.2_Missense_Mutation_p.K128N	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	128					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						ACAAGACCAAGGAGGCGGCGG	0.617000												
SETD2	29072	broad.mit.edu	37	3	47155459	47155459	+	Missense_Mutation	SNP	T	T	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr3:47155459T>C	uc003cqs.2	-	5	4675	c.4622A>G	c.(4621-4623)AAT>AGT	p.N1541S	SETD2_uc003cqv.2_Missense_Mutation_p.N1530S	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1541	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AAACCGTCTATTGGAACAATA	0.398000			N|F|S|Mis		clear cell renal carcinoma							
LAMB2	3913	broad.mit.edu	37	3	49167420	49167420	+	Silent	SNP	G	G	A	rs146643686		TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr3:49167420G>A	uc003cwe.2	-	10	1556	c.1257C>T	c.(1255-1257)GAC>GAT	p.D419D	LAMB2_uc003cwf.1_Silent_p.D419D	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	419	Laminin EGF-like 3.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGCGACCACCGTCTTGAGAAC	0.562000												
PARP3	10039	broad.mit.edu	37	3	51979157	51979157	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr3:51979157G>A	uc003dby.2	+	6	1149	c.778G>A	c.(778-780)GTC>ATC	p.V260I	PARP3_uc003dbz.2_Missense_Mutation_p.V267I	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	260	PARP alpha-helical.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CTTTTACACCGTCATCCCGCA	0.637000												
PPARGC1A	10891	broad.mit.edu	37	4	23815403	23815403	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr4:23815403C>T	uc003gqs.2	-	8	1823	c.1703G>A	c.(1702-1704)CGT>CAT	p.R568H	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	568	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				GGACCTTGAACGAGAGCGCAT	0.453000												
CORIN	10699	broad.mit.edu	37	4	47746513	47746513	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr4:47746513C>T	uc003gxm.2	-	5	798	c.705G>A	c.(703-705)CCG>CCA	p.P235P	CORIN_uc011bzf.1_Silent_p.P96P|CORIN_uc011bzg.1_Silent_p.P168P|CORIN_uc011bzh.1_Silent_p.P235P|CORIN_uc011bzi.1_Silent_p.P235P|CORIN_uc003gxn.3_Silent_p.P235P	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	235	Extracellular (Potential).|FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						TGAGGAAATCCGGCCAGGAGT	0.463000												
UGT2A1	10941	broad.mit.edu	37	4	70455255	70455255	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr4:70455255G>C	uc003hem.3	-	6	1482	c.1419C>G	c.(1417-1419)CAC>CAG	p.H473Q	UGT2A1_uc011caq.1_Missense_Mutation_p.H639Q|UGT2A1_uc010ihu.2_Missense_Mutation_p.H473Q|UGT2A1_uc010iht.2_Missense_Mutation_p.H429Q|UGT2A1_uc010ihs.2_Missense_Mutation_p.H474Q	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	473	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						CAACCCGAAGGTGCTTGGCTC	0.488000												
EREG	2069	broad.mit.edu	37	4	75246757	75246757	+	Missense_Mutation	SNP	G	G	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr4:75246757G>T	uc003hie.1	+	3	347	c.181G>T	c.(181-183)GCT>TCT	p.A61S	EREG_uc003hid.2_Missense_Mutation_p.A55S	NM_001432	NP_001423	O14944	EREG_HUMAN	epiregulin preproprotein	61	Extracellular (Potential).				angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|skin(1)	2			Lung(101;0.196)			TCCACGTGTGGCTCAAGTGTC	0.398000												
TRIML1	339976	broad.mit.edu	37	4	189068387	189068387	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr4:189068387G>A	uc003izm.1	+	6	1383	c.1268G>A	c.(1267-1269)GGG>GAG	p.G423E	TRIML1_uc003izn.1_Missense_Mutation_p.G147E	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	423	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		TTCTACAACGGGACGGATGAA	0.517000												
EMB	133418	broad.mit.edu	37	5	49699147	49699147	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr5:49699147C>A	uc003jom.2	-	6	991	c.742G>T	c.(742-744)GAA>TAA	p.E248*	EMB_uc010ivq.2_Nonsense_Mutation_p.E42*|EMB_uc003jol.2_Nonsense_Mutation_p.E179*|EMB_uc011cpy.1_Nonsense_Mutation_p.E198*|EMB_uc010ivr.2_Nonsense_Mutation_p.E194*	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	248	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TCAATGTGTTCTTCACTCTCG	0.438000												
ANKRD55	79722	broad.mit.edu	37	5	55407441	55407441	+	Silent	SNP	G	G	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr5:55407441G>T	uc003jqu.2	-	10	1286	c.1134C>A	c.(1132-1134)GTC>GTA	p.V378V	ANKRD55_uc003jqt.2_Silent_p.V90V	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	377										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TGATGTCATTGACTTCTGAGG	0.468000												
NLN	57486	broad.mit.edu	37	5	65088312	65088312	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr5:65088312G>A	uc003juf.2	+	9	1473	c.1357G>A	c.(1357-1359)GGT>AGT	p.G453S	NLN_uc003jue.2_Missense_Mutation_p.G453S|NLN_uc003jug.2_Missense_Mutation_p.G282S|NLN_uc010iww.2_Missense_Mutation_p.G148S	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	453					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		GGCCTGCTTCGGTCTCCAGCC	0.562000												
IRF1	3659	broad.mit.edu	37	5	131822042	131822042	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr5:131822042T>A	uc003kxa.2	-	7	802	c.568A>T	c.(568-570)AGC>TGC	p.S190C	C5orf56_uc010jds.1_Missense_Mutation_p.L68Q|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.S190C|IRF1_uc010jdt.1_Missense_Mutation_p.S190C	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	190					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		GGGAGAGTGCTGCTGACAGCA	0.572000												
SEC24A	10802	broad.mit.edu	37	5	134044579	134044579	+	Splice_Site	SNP	G	G	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr5:134044579G>T	uc003kzs.2	+	18	3015	c.2727_splice	c.e18+1	p.Q909_splice	SEC24A_uc011cxu.1_Splice_Site_p.Q673_splice	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTTAAACAGGTAAGAAAAAC	0.269000												
SLC35B3	51000	broad.mit.edu	37	6	8430176	8430176	+	Missense_Mutation	SNP	C	C	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr6:8430176C>A	uc010joe.2	-	3	384	c.218G>T	c.(217-219)AGC>ATC	p.S73I	SLC35B3_uc003mya.2_Missense_Mutation_p.S41I|SLC35B3_uc003myc.2_RNA|SLC35B3_uc003myb.2_Missense_Mutation_p.S73I|SLC35B3_uc011did.1_Missense_Mutation_p.S73I|SLC35B3_uc003myd.2_RNA|SLC35B3_uc010jof.2_Missense_Mutation_p.S41I|SLC35B3_uc011die.1_Missense_Mutation_p.S73I	NM_001142541	NP_001136013	Q9H1N7	S35B3_HUMAN	solute carrier family 35, member B3	73					transmembrane transport	Golgi membrane|integral to membrane					0	Ovarian(93;0.0569)					GTTAAACTTGCTGAGATTCAT	0.348000												
OR5V1	81696	broad.mit.edu	37	6	29323192	29323192	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr6:29323192G>A	uc011dlo.1	-	1	863	c.781C>T	c.(781-783)CGG>TGG	p.R261W		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R261Q(1)		ovary(3)|kidney(1)	4						GAGATGGGCCGTACATATGTA	0.438000												
LY6G6C	80740	broad.mit.edu	37	6	31686897	31686897	+	Silent	SNP	G	G	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr6:31686897G>C	uc003nwh.2	-	3	408	c.354C>G	c.(352-354)GGC>GGG	p.G118G	LY6G6C_uc010jtd.2_RNA	NM_025261	NP_079537	O95867	LY66C_HUMAN	lymphocyte antigen 6 complex G6C precursor	118						anchored to membrane|plasma membrane					0						AGAGGCCAAGGCCAGCCAAGG	0.607000												
GFRAL	389400	broad.mit.edu	37	6	55216354	55216354	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr6:55216354G>A	uc003pcm.1	+	5	760	c.674G>A	c.(673-675)CGC>CAC	p.R225H		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	225	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGTGTAATTCGCAGCTGCCAA	0.428000												
HIVEP2	3097	broad.mit.edu	37	6	143095264	143095264	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr6:143095264C>T	uc003qjd.2	-	5	1355	c.612G>A	c.(610-612)CTG>CTA	p.L204L		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	204	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TGTGTTTTTTCAGTACACTAG	0.463000												
MTHFD1L	25902	broad.mit.edu	37	6	151257996	151257996	+	Missense_Mutation	SNP	A	A	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr6:151257996A>G	uc003qob.2	+	12	1581	c.1313A>G	c.(1312-1314)CAG>CGG	p.Q438R	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Missense_Mutation_p.Q439R|MTHFD1L_uc003qoc.2_Missense_Mutation_p.Q386R	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	438	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		GGGCTTGTGCAGGCTCTGACC	0.512000												
DLL1	28514	broad.mit.edu	37	6	170594221	170594221	+	Missense_Mutation	SNP	A	A	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr6:170594221A>T	uc003qxm.2	-	8	1505	c.1035T>A	c.(1033-1035)GAT>GAA	p.D345E		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	345	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TGTTCTCGAGATCCTACACGA	0.557000												
SDK1	221935	broad.mit.edu	37	7	4273010	4273010	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr7:4273010C>T	uc003smx.2	+	41	6090	c.5951C>T	c.(5950-5952)GCG>GTG	p.A1984V	SDK1_uc010kso.2_Missense_Mutation_p.A1240V|SDK1_uc003smy.2_Missense_Mutation_p.A471V|SDK1_uc003smz.2_Missense_Mutation_p.A44V	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1984	Fibronectin type-III 13.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTGAATGAGGCGGGCTACGGG	0.622000												
C7orf16	10842	broad.mit.edu	37	7	31735216	31735216	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr7:31735216C>T	uc003tcl.2	+	3	374	c.216C>T	c.(214-216)CAC>CAT	p.H72H	C7orf16_uc011kaf.1_Intron	NM_006658	NP_006649	O96001	GSUB_HUMAN	G-substrate isoform 1	72					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction				ovary(2)|central_nervous_system(1)	3			GBM - Glioblastoma multiforme(11;0.216)			CGGCGCTGCACATCCCACCTT	0.443000												
LAMB1	3912	broad.mit.edu	37	7	107572693	107572693	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr7:107572693C>T	uc003vew.2	-	28	4653	c.4318G>A	c.(4318-4320)GCC>ACC	p.A1440T	LAMB1_uc003vev.2_Missense_Mutation_p.A1464T|LAMB1_uc003veu.2_5'Flank	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1440	Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCTGCCAGGCGTTGTGTGCA	0.552000												
GCC1	79571	broad.mit.edu	37	7	127222337	127222337	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr7:127222337G>A	uc003vma.2	-	2	2477	c.2059C>T	c.(2059-2061)CGG>TGG	p.R687W		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	687	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TCCAGCAGCCGATCCTGCAGC	0.592000												
XRCC2	7516	broad.mit.edu	37	7	152346034	152346034	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr7:152346034C>T	uc003wld.2	-	3	622	c.536G>A	c.(535-537)TGC>TAC	p.C179Y		NM_005431	NP_005422	O43543	XRCC2_HUMAN	X-ray repair cross complementing protein 2	179					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			breast(1)|liver(1)	2		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		CTTCTCTAAGCACTGAGAACA	0.433000								Homologous_recombination				
TMEM215	401498	broad.mit.edu	37	9	32784506	32784506	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr9:32784506G>A	uc003zri.3	+	2	690	c.325G>A	c.(325-327)GAT>AAT	p.D109N		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	109						integral to membrane					0						GGGGAGCTCAGATGAGCTGGC	0.617000												
KIAA1045	23349	broad.mit.edu	37	9	34976588	34976588	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr9:34976588G>A	uc003zvq.2	+	5	878	c.700G>A	c.(700-702)GGG>AGG	p.G234R	KIAA1045_uc003zvr.2_Missense_Mutation_p.G234R	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	234							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			AGCCAAGCGGGGGGACCGTGA	0.632000												
IARS	3376	broad.mit.edu	37	9	95004524	95004524	+	Missense_Mutation	SNP	G	G	C			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr9:95004524G>C	uc004art.1	-	29	3346	c.3089C>G	c.(3088-3090)ACA>AGA	p.T1030R	IARS_uc004ars.1_Missense_Mutation_p.T875R|IARS_uc004aru.3_Missense_Mutation_p.T1030R|IARS_uc010mqr.2_Missense_Mutation_p.T920R|IARS_uc010mqt.2_Missense_Mutation_p.T253R	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	1030					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	TATGAACTCTGTGTGGCTTTC	0.388000												
OR1L4	254973	broad.mit.edu	37	9	125487043	125487043	+	Missense_Mutation	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr9:125487043G>A	uc004bmu.1	+	1	775	c.775G>A	c.(775-777)GTC>ATC	p.V259I		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	259	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGTCATCTATGTCTATTTTAG	0.517000												
DPP7	29952	broad.mit.edu	37	9	140006168	140006168	+	Missense_Mutation	SNP	T	T	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr9:140006168T>A	uc004clh.2	-	11	1276	c.1246A>T	c.(1246-1248)AAC>TAC	p.N416Y		NM_013379	NP_037511	Q9UHL4	DPP2_HUMAN	dipeptidyl peptidase 7 preproprotein	416						cytoplasmic membrane-bounded vesicle|extracellular region|lysosome	aminopeptidase activity|protein binding|serine-type peptidase activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;4.25e-05)|Epithelial(140;0.000633)		GGGTCCAGGTTCCCGTTGGAG	0.517000												
ZMYM3	9203	broad.mit.edu	37	X	70462830	70462830	+	Silent	SNP	G	G	A			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chrX:70462830G>A	uc004dzh.1	-	22	3624	c.3537C>T	c.(3535-3537)CTC>CTT	p.L1179L	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.L1179L|ZMYM3_uc004dzj.1_Silent_p.L1167L	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1179					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TGTTGGGGAGGAGTGTGGGCT	0.502000												
PABPC5	140886	broad.mit.edu	37	X	90690785	90690785	+	Missense_Mutation	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chrX:90690785C>T	uc004efg.2	+	2	649	c.209C>T	c.(208-210)GCG>GTG	p.A70V	PABPC5_uc004eff.1_Intron	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	70	RRM 1.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CGCTTTCCCGCGGATGCAGAG	0.527000												
PCDH11X	27328	broad.mit.edu	37	X	91873417	91873417	+	Silent	SNP	C	C	T			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chrX:91873417C>T	uc004efk.1	+	7	4367	c.3522C>T	c.(3520-3522)AGC>AGT	p.S1174S	PCDH11X_uc004efl.1_Silent_p.S1164S|PCDH11X_uc004efo.1_Silent_p.S1137S|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Silent_p.S1166S|PCDH11X_uc004efn.1_Silent_p.S1156S	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1174	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TATGCCACAGCCCACCACTGT	0.557000												
AFF2	2334	broad.mit.edu	37	X	148048538	148048538	+	Silent	SNP	C	C	G			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chrX:148048538C>G	uc004fcp.2	+	14	3611	c.3132C>G	c.(3130-3132)TCC>TCG	p.S1044S	AFF2_uc004fcq.2_Silent_p.S1034S|AFF2_uc004fcr.2_Silent_p.S1005S|AFF2_uc011mxb.1_Silent_p.S1009S|AFF2_uc004fcs.2_Silent_p.S1009S|AFF2_uc011mxc.1_Silent_p.S685S	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1044					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					AGATGACGTCCTGGGCGGCTC	0.358000												
TMTC1	83857	broad.mit.edu	37	12	29670442	29670457	+	Frame_Shift_Del	DEL	GTGTTGTAATACAGTG	GTGTTGTAATACAGTG	-	rs112380600		TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr12:29670441_29670456AGTGTTGTAATACAGTG>A	uc021qwi.1	-	13	2132_2147	c.2073_2088CACTGTATTACAACACT>T	c.(2071-2088)gcactgtattacaacactfs	p.A691fs	TMTC1_uc001riz.3_Frame_Shift_Del_p.A340fs|TMTC1_uc001rja.3_Frame_Shift_Del_p.A427fs|TMTC1_uc001rjb.3_Frame_Shift_Del_p.A583fs|TMTC1_uc001riy.3_Frame_Shift_Del_p.A36fs	NM_001193451	NP_001180380	Q8IUR5	TMTC1_HUMAN	Homo sapiens transmembrane and tetratricopeptide repeat containing 1 (TMTC1), transcript variant 1, mRNA.	691						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CGTATCGGCCAGTGTTGTAATACAGTGCTCCCAAAG	0.472												
AKAP6	9472	broad.mit.edu	37	14	32902831	32902831	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr14:32902830_32902830AG>A	uc001wrq.3	+	1	301	c.131_131AG>A	c.(130-132)aagfs	p.K44fs	AKAP6_uc010aml.3_Frame_Shift_Del_p.K41fs	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 6 (AKAP6), mRNA.	44					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAGGCAATGAAGGACATGGAC	0.542												
MED6	10001	broad.mit.edu	37	14	71060070	71060075	+	In_Frame_Del	DEL	GATATA	GATATA	-			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr14:71060069_71060074TGATATA>T	uc010tth.2	-	3	326_331	c.296_301TATATCA>A	c.(295-303)tatatcatt>tAtt	p.II100del	MED6_uc001xmf.3_In_Frame_Del_p.II100del|MED6_uc010tti.2_In_Frame_Del_p.II100del|MED6_uc001xmg.1_In_Frame_Del_p.II100del|MED6_uc010ttj.2_In_Frame_Del_p.II100del	NM_005466	NP_005457	O75586	MED6_HUMAN	Homo sapiens mediator complex subunit 6 (MED6), mRNA.	100					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	transcription coactivator activity			large_intestine(2)|lung(2)|skin(1)	5				all cancers(60;0.00315)|BRCA - Breast invasive adenocarcinoma(234;0.00685)|OV - Ovarian serous cystadenocarcinoma(108;0.0352)		ACTCCAGCAATGATATAGTAATCAGC	0.335												
CSPG4	1464	broad.mit.edu	37	15	75982987	75982987	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr15:75982986_75982986TA>T	uc002baw.3	-	2	513	c.420_420TA>A	c.(418-420)ctafs	p.L140fs		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	Homo sapiens chondroitin sulfate proteoglycan 4 (CSPG4), mRNA.	140	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						AGGGGACCTCTAGGGGGGCTC	0.642												
ROCK1	6093	broad.mit.edu	37	18	18625286	18625287	+	In_Frame_Ins	INS	-	-	AAA			TCGA-D7-6518-01A-11D-1800-08	TCGA-D7-6518-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19406c86-dd55-420c-b6d4-b5ca9d3bfed6	8a32dd74-fa56-4328-917e-37c29e44cb47	g.chr18:18625285_18625286C>CAAA	uc002kte.3	-	4	1498_1499	c.557_558G>TTTG	c.(556-558)ttg>tTTTG	p.L186F		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Homo sapiens Rho-associated, coiled-coil containing protein kinase 1 (ROCK1), mRNA.	186	Protein kinase.				Rho protein signal transduction|actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking	Golgi membrane|centriole|cytosol	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					GGATTGCATCCAATGCAAGAAC	0.347