Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PIK3CD	5293	broad.mit.edu	37	1	9770626	9770626	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:9770626G>A	uc001aqb.3	+	3	321	c.113G>A	c.(112-114)CGC>CAC	p.R38H	PIK3CD_uc001aqa.2_Missense_Mutation_p.R38H|PIK3CD_uc010oaf.1_Missense_Mutation_p.R38H|PIK3CD_uc001aqe.3_Missense_Mutation_p.R38H	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	38					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGTGTCCCGCAATGCCAAC	0.468000												
PRAMEF6	440561	broad.mit.edu	37	1	13001329	13001329	+	Missense_Mutation	SNP	T	T	G			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:13001329T>G	uc001auq.2	-	3	440	c.354A>C	c.(352-354)GAA>GAC	p.E118D	PRAMEF5_uc001aur.2_Intron	NM_001010889	NP_001010889	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	118											0	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCCATAGCTTCAGACCAAA	0.493000												
HP1BP3	50809	broad.mit.edu	37	1	21076258	21076258	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:21076258A>G	uc001bdw.1	-	10	1239	c.1099T>C	c.(1099-1101)TAT>CAT	p.Y367H	HP1BP3_uc001bdv.1_Missense_Mutation_p.Y329H|HP1BP3_uc010odh.1_Missense_Mutation_p.Y329H|HP1BP3_uc001bdy.1_Missense_Mutation_p.Y367H|HP1BP3_uc010odf.1_Missense_Mutation_p.Y26H|HP1BP3_uc010odg.1_Missense_Mutation_p.Y215H	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	367	H15 3.				nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		TCTAGGACATACTTCTTCAGA	0.428000												
ZDHHC18	84243	broad.mit.edu	37	1	27159097	27159097	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:27159097C>T	uc001bnb.2	+	2	590	c.495C>T	c.(493-495)ATC>ATT	p.I165I	ZDHHC18_uc010ofh.1_Silent_p.I30I	NM_032283	NP_115659	Q9NUE0	ZDH18_HUMAN	zinc finger, DHHC-type containing 18	165						integral to membrane	zinc ion binding				0		all_cancers(24;5.82e-22)|all_epithelial(13;9.91e-20)|Colorectal(325;0.000147)|Breast(348;0.000706)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;5.71e-53)|Epithelial(14;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(117;1.53e-29)|Colorectal(126;1.9e-09)|COAD - Colon adenocarcinoma(152;4.2e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000548)|STAD - Stomach adenocarcinoma(196;0.00065)|KIRC - Kidney renal clear cell carcinoma(1967;0.000779)|GBM - Glioblastoma multiforme(114;0.0265)|READ - Rectum adenocarcinoma(331;0.0455)|Lung(427;0.163)|LUSC - Lung squamous cell carcinoma(448;0.237)		AGAAACAGATCGGTGAGGTTT	0.532000												
GJA8	2703	broad.mit.edu	37	1	147381081	147381081	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:147381081C>T	uc001epu.1	+	2	1062	c.999C>T	c.(997-999)GGC>GGT	p.G333G		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	333	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					AAGTGGAGGGCGAGGGGCCGC	0.647000												
FLG	2312	broad.mit.edu	37	1	152285654	152285654	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:152285654G>T	uc001ezu.1	-	3	1744	c.1708C>A	c.(1708-1710)CAA>AAA	p.Q570K	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	570	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTCGTGTTTGTCTGCTTGCA	0.537000									Ichthyosis			
C1orf129	80133	broad.mit.edu	37	1	170967420	170967420	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:170967420G>T	uc001ghg.2	+	15	1731	c.1601G>T	c.(1600-1602)AGT>ATT	p.S534I	C1orf129_uc009wvy.2_Missense_Mutation_p.S341I|C1orf129_uc010plz.1_Intron	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	534							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACTGAAGTGAGTTTTGTAGAC	0.398000												
PAPPA2	60676	broad.mit.edu	37	1	176526217	176526217	+	Silent	SNP	C	C	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:176526217C>A	uc001gkz.2	+	2	1923	c.759C>A	c.(757-759)ACC>ACA	p.T253T	PAPPA2_uc001gky.1_Silent_p.T253T|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	253					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AAGCAGAGACCTTTAACTCCC	0.557000												
RGS18	64407	broad.mit.edu	37	1	192127860	192127860	+	Missense_Mutation	SNP	A	A	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:192127860A>C	uc001gsg.2	+	1	269	c.93A>C	c.(91-93)GAA>GAC	p.E31D		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	31					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						CAGGAAAAGAAGAAACAAGCA	0.294000												
ARV1	64801	broad.mit.edu	37	1	231131557	231131557	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:231131557C>T	uc009xfl.1	+	4	529	c.500C>T	c.(499-501)CCC>CTC	p.P167L	ARV1_uc001huh.2_Missense_Mutation_p.P167L	NM_022786	NP_073623	Q9H2C2	ARV1_HUMAN	ARV1 homolog	167					sphingolipid metabolic process	integral to membrane				breast(2)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		GTAGAACGGCCCATGACGGCA	0.373000												
FMN2	56776	broad.mit.edu	37	1	240286542	240286542	+	Missense_Mutation	SNP	A	A	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr1:240286542A>C	uc010pyd.1	+	2	1904	c.1679A>C	c.(1678-1680)AAG>ACG	p.K560T	FMN2_uc010pye.1_Missense_Mutation_p.K560T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	560					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAAGCAGAGAAGTTTTGCTCC	0.512000												
ENKUR	219670	broad.mit.edu	37	10	25273753	25273753	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr10:25273753G>A	uc001isg.1	-	5	841	c.676C>T	c.(676-678)CGC>TGC	p.R226C	ENKUR_uc001ish.1_Missense_Mutation_p.R164C	NM_145010	NP_659447	Q8TC29	ENKUR_HUMAN	enkurin	226						cilium|flagellum	calmodulin binding|SH3 domain binding				0						CTCTGCTTGCGGATCTTCTTT	0.388000												
FRMPD2	143162	broad.mit.edu	37	10	49420007	49420007	+	Missense_Mutation	SNP	T	T	G			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr10:49420007T>G	uc001jgi.2	-	13	1708	c.1601A>C	c.(1600-1602)AAG>ACG	p.K534T	FRMPD2_uc001jgh.2_Missense_Mutation_p.K502T|FRMPD2_uc001jgj.2_Missense_Mutation_p.K512T	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	534	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CCTCAAGAACTTCAGCTCAGC	0.582000												
GRID1	2894	broad.mit.edu	37	10	87482893	87482893	+	Missense_Mutation	SNP	C	C	T	rs148165863		TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr10:87482893C>T	uc001kdl.1	-	12	1965	c.1864G>A	c.(1864-1866)GAA>AAA	p.E622K	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.E193K	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	622	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	ACGGAAGATTCGCCACCTGCG	0.602000										Multiple Myeloma(13;0.14)		
SORCS3	22986	broad.mit.edu	37	10	106907471	106907471	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr10:106907471C>T	uc001kyi.1	+	9	1626	c.1399C>T	c.(1399-1401)CGT>TGT	p.R467C		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	467	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTCAGACACGCGTGGGATTTA	0.453000												
SORCS1	114815	broad.mit.edu	37	10	108458997	108458997	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr10:108458997C>T	uc001kym.2	-	9	1396	c.1388G>A	c.(1387-1389)GGC>GAC	p.G463D	SORCS1_uc001kyl.2_Missense_Mutation_p.G463D|SORCS1_uc009xxs.2_Missense_Mutation_p.G463D|SORCS1_uc001kyn.1_Missense_Mutation_p.G463D|SORCS1_uc001kyo.2_Missense_Mutation_p.G463D	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	463	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CATGATGTTGCCCTCAGGGCC	0.542000												
MKI67	4288	broad.mit.edu	37	10	129907388	129907388	+	Missense_Mutation	SNP	T	T	G			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr10:129907388T>G	uc001lke.2	-	13	2911	c.2716A>C	c.(2716-2718)AAA>CAA	p.K906Q	MKI67_uc001lkf.2_Missense_Mutation_p.K546Q|MKI67_uc009yav.1_Missense_Mutation_p.K481Q|MKI67_uc009yaw.1_Missense_Mutation_p.K56Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	906					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGACCTCTTTTTAGGATGCAC	0.363000												
ADAM8	101	broad.mit.edu	37	10	135083907	135083907	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr10:135083907G>A	uc010qva.1	-	15	1676	c.1625C>T	c.(1624-1626)GCG>GTG	p.A542V	ADAM8_uc010quz.1_Missense_Mutation_p.A581V|ADAM8_uc009ybi.2_Missense_Mutation_p.A581V			P78325	ADAM8_HUMAN	SubName: Full=cDNA FLJ50704, highly similar to ADAM 8 (EC 3.4.24.-) (A disintegrinand metalloproteinase domain 8);	542					integrin-mediated signaling pathway|proteolysis		metalloendopeptidase activity			large_intestine(2)|central_nervous_system(1)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;7.72e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.23e-06)|Epithelial(32;1.02e-05)		TGGTTCATACGCAGTGCCATC	0.672000												
NUP160	23279	broad.mit.edu	37	11	47837151	47837151	+	Silent	SNP	A	A	G			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr11:47837151A>G	uc001ngm.2	-	13	1651	c.1566T>C	c.(1564-1566)AAT>AAC	p.N522N	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	522					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						CTTGTTGTAAATTTCGAAACT	0.403000												
OR4D6	219983	broad.mit.edu	37	11	59224624	59224624	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr11:59224624G>A	uc010rku.1	+	1	191	c.191G>A	c.(190-192)CGG>CAG	p.R64Q		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTTCTCCTGCGGAACAAATCA	0.458000												
MS4A13	503497	broad.mit.edu	37	11	60285672	60285672	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr11:60285672T>A	uc001nps.2	+	3	439	c.116T>A	c.(115-117)TTA>TAA	p.L39*	MS4A13_uc009ync.2_Nonsense_Mutation_p.L39*|MS4A13_uc009ynd.2_Nonsense_Mutation_p.L39*	NM_001012417	NP_001012417	Q5J8X5	M4A13_HUMAN	membrane-spanning 4-domains, subfamily A, member	39	Helical; (Potential).					integral to membrane					0						GGATGTACTTTATGGGGAATT	0.323000												
RAB38	23682	broad.mit.edu	37	11	87883041	87883041	+	Silent	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr11:87883041T>C	uc001pcj.1	-	2	332	c.285A>G	c.(283-285)CCA>CCG	p.P95P		NM_022337	NP_071732	P57729	RAB38_HUMAN	RAB38	95					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CAAATGTGGCTGGCCTGGTGA	0.428000												
CNTN5	53942	broad.mit.edu	37	11	99827732	99827732	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr11:99827732C>T	uc001pga.2	+	8	1207	c.868C>T	c.(868-870)CGT>TGT	p.R290C	CNTN5_uc009ywv.1_Missense_Mutation_p.R290C|CNTN5_uc001pfz.2_Missense_Mutation_p.R290C|CNTN5_uc001pgb.2_Missense_Mutation_p.R216C	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	290					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACTCACTCTGCGTAATGATGG	0.398000												
SIK3	23387	broad.mit.edu	37	11	116718205	116718205	+	Missense_Mutation	SNP	A	A	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr11:116718205A>T	uc001ppy.2	-	22	3657	c.3621T>A	c.(3619-3621)GAT>GAA	p.D1207E	SIK3_uc001ppz.2_Missense_Mutation_p.D1046E|SIK3_uc001pqa.2_Missense_Mutation_p.D1147E|SIK3_uc001ppw.2_Missense_Mutation_p.D564E|SIK3_uc001ppx.2_Missense_Mutation_p.D585E	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	1207						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						CATTTTCCCCATCCTGAAACT	0.562000												
OR6X1	390260	broad.mit.edu	37	11	123624910	123624910	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr11:123624910C>T	uc010rzy.1	-	1	317	c.317G>A	c.(316-318)GGC>GAC	p.G106D		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTCGGTGGTGCCCACGAAGAA	0.522000												
ADAMTS8	11095	broad.mit.edu	37	11	130278390	130278390	+	Missense_Mutation	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr11:130278390T>C	uc001qgg.3	-	8	2426	c.2068A>G	c.(2068-2070)AGG>GGG	p.R690G	ADAMTS8_uc001qgf.2_Missense_Mutation_p.R171G	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	690	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GAGACCTTCCTGCAGGAGTTG	0.512000												
KCNA6	3742	broad.mit.edu	37	12	4920073	4920073	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr12:4920073C>T	uc001qng.2	+	1	1732	c.866C>T	c.(865-867)CCG>CTG	p.P289L		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	289						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						CCTAGCAAGCCGGCCTTCTTC	0.552000										HNSCC(72;0.22)		
TMEM106C	79022	broad.mit.edu	37	12	48359740	48359740	+	Missense_Mutation	SNP	C	C	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr12:48359740C>A	uc001rqp.2	+	4	486	c.371C>A	c.(370-372)ACA>AAA	p.T124K	TMEM106C_uc001rqo.2_Missense_Mutation_p.T124K|TMEM106C_uc001rqr.2_Missense_Mutation_p.T124K|TMEM106C_uc001rqq.2_Missense_Mutation_p.T124K	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	124						endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		GTGAAAGTCACATTTAATAAG	0.488000												
GRIP1	23426	broad.mit.edu	37	12	66935616	66935616	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr12:66935616C>T	uc001stk.2	-	3	492	c.251G>A	c.(250-252)CGG>CAG	p.R84Q	GRIP1_uc010sta.1_Missense_Mutation_p.R28Q|GRIP1_uc001stl.1_Missense_Mutation_p.R28Q|GRIP1_uc001stm.2_Missense_Mutation_p.R84Q	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	84	PDZ 1.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		TCCTCCTTGCCGCAGATTAGA	0.463000												
CIT	11113	broad.mit.edu	37	12	120271923	120271923	+	Missense_Mutation	SNP	A	A	G	rs75000396		TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr12:120271923A>G	uc001txi.1	-	6	679	c.626T>C	c.(625-627)GTT>GCT	p.V209A	CIT_uc001txj.1_Missense_Mutation_p.V209A	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	209	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		AACGCTGTGAACAGCCAAAAT	0.443000												
EP400	57634	broad.mit.edu	37	12	132497672	132497672	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr12:132497672G>A	uc001ujn.2	+	16	3595	c.3560G>A	c.(3559-3561)CGC>CAC	p.R1187H	EP400_uc001ujl.2_Missense_Mutation_p.R1186H|EP400_uc001ujm.2_Missense_Mutation_p.R1187H	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1223	Interactions with RUVBL1 and RUVBL2.|Helicase ATP-binding.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAGATGCAGCGCGTGAAGGGC	0.557000												
DDX51	317781	broad.mit.edu	37	12	132627302	132627302	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr12:132627302C>T	uc001ujy.3	-	3	680	c.641G>A	c.(640-642)CGG>CAG	p.R214Q	NOC4L_uc001ujz.1_5'Flank	NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	214					rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		GCCGTGTGCCCGCAGCTGCTT	0.617000												
TNFRSF19	55504	broad.mit.edu	37	13	24190168	24190168	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr13:24190168G>A	uc001uov.1	+	4	407	c.343G>A	c.(343-345)GGG>AGG	p.G115R	TNFRSF19_uc001uot.2_Missense_Mutation_p.G115R|TNFRSF19_uc010tcu.1_5'UTR|TNFRSF19_uc001uow.2_Missense_Mutation_p.G115R	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	115	Extracellular (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TGCCATCTGCGGGGACTGCTT	0.473000												
KPNA3	3839	broad.mit.edu	37	13	50279772	50279772	+	Missense_Mutation	SNP	T	T	C	rs79884028		TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr13:50279772T>C	uc001vdj.2	-	15	1772	c.1357A>G	c.(1357-1359)ATA>GTA	p.I453V		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	453	ARM 10; atypical.				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		CATTCCTCTATTATTTCAGCT	0.383000												
ABCC4	10257	broad.mit.edu	37	13	95859004	95859004	+	Missense_Mutation	SNP	A	A	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr13:95859004A>T	uc001vmd.3	-	8	1062	c.943T>A	c.(943-945)TGC>AGC	p.C315S	ABCC4_uc010afk.2_Missense_Mutation_p.C315S|ABCC4_uc001vme.2_Missense_Mutation_p.C315S|ABCC4_uc010tih.1_Missense_Mutation_p.C240S|ABCC4_uc001vmf.2_Missense_Mutation_p.C272S|ABCC4_uc010afl.1_Missense_Mutation_p.C272S|ABCC4_uc010afm.1_Missense_Mutation_p.C328S	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	315	ABC transmembrane type-1 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CCTCTGAGGCAGGAACTTCTC	0.393000												
KDELC1	79070	broad.mit.edu	37	13	103446097	103446097	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr13:103446097C>T	uc001vpq.3	-	3	832	c.448G>A	c.(448-450)GAG>AAG	p.E150K	KDELC1_uc001vpr.3_5'UTR	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	150						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CAGTTCATCTCCCGTAGCCAG	0.438000												
OR4L1	122742	broad.mit.edu	37	14	20529107	20529107	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr14:20529107C>T	uc001vwn.1	+	1	904	c.904C>T	c.(904-906)CGG>TGG	p.R302W		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	302	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R302L(1)		ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		AAGAAAATTACGGTTCCAATA	0.303000												
ZFYVE26	23503	broad.mit.edu	37	14	68244307	68244307	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr14:68244307C>T	uc001xka.2	-	25	5082	c.4943G>A	c.(4942-4944)CGT>CAT	p.R1648H	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.R1648H	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1648					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CTGGATTTCACGGTGTCGGAC	0.532000												
SPTBN5	51332	broad.mit.edu	37	15	42143986	42143986	+	Silent	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr15:42143986G>A	uc001zos.2	-	63	10875	c.10542C>T	c.(10540-10542)GGC>GGT	p.G3514G		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3549	PH.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CCTGCCTCCCGCCAGGCAGCA	0.597000												
ADAM10	102	broad.mit.edu	37	15	58920052	58920052	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr15:58920052C>T	uc002afd.1	-	10	1651	c.1207G>A	c.(1207-1209)GAA>AAA	p.E403K	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.E102K|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	403	Peptidase M12B.|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		TTCTTAGATTCTCCTGGTGTG	0.348000												
BTBD12	84464	broad.mit.edu	37	16	3639390	3639390	+	Missense_Mutation	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr16:3639390T>C	uc002cvp.2	-	12	4876	c.4249A>G	c.(4249-4251)AGT>GGT	p.S1417G		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1417	Interaction with MUS81.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GGGGGGTCACTGTCCAGTGGG	0.622000								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia			
BTBD12	84464	broad.mit.edu	37	16	3640449	3640449	+	Missense_Mutation	SNP	C	C	T	rs142079276	byFrequency	TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr16:3640449C>T	uc002cvp.2	-	12	3817	c.3190G>A	c.(3190-3192)GGA>AGA	p.G1064R		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1064	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						TGGGAAGTTCCGCCACGGGAC	0.637000								Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia			
NOMO1	23420	broad.mit.edu	37	16	14970589	14970589	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr16:14970589C>T	uc002dcv.2	+	22	2651	c.2585C>T	c.(2584-2586)GCG>GTG	p.A862V		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	862	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						GTTCTGACTGCGGTGGAAGGA	0.473000												
SRCAP	10847	broad.mit.edu	37	16	30750658	30750658	+	Silent	SNP	C	C	T	rs146224299		TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr16:30750658C>T	uc002dze.1	+	34	9682	c.9297C>T	c.(9295-9297)AGC>AGT	p.S3099S	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.S2894S	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	3099					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TAGCAGATAGCGGGCCAGGCG	0.592000												
PYCARD	29108	broad.mit.edu	37	16	31213016	31213016	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr16:31213016G>A	uc010cak.2	-	3	718	c.478C>T	c.(478-480)CGG>TGG	p.R160W	PYCARD_uc002ebm.2_Missense_Mutation_p.R141W	NM_013258	NP_037390	Q9ULZ3	ASC_HUMAN	PYD and CARD domain containing isoform a	160	CARD.				induction of apoptosis|positive regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex	caspase activator activity|cysteine-type endopeptidase activity|protein homodimerization activity|Pyrin domain binding				0						AAGAGCTTCCGCATCTTGCTT	0.597000												
DYNC1LI2	1783	broad.mit.edu	37	16	66759770	66759770	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr16:66759770G>A	uc002eqb.1	-	12	1370	c.1339C>T	c.(1339-1341)CCT>TCT	p.P447S	DYNC1LI2_uc010vis.1_Missense_Mutation_p.P370S	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	447					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		CCAGCACCAGGACTTCCAGGA	0.488000												
ELMO3	79767	broad.mit.edu	37	16	67237416	67237416	+	Missense_Mutation	SNP	C	C	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr16:67237416C>A	uc002esa.2	+	19	2082	c.2039C>A	c.(2038-2040)GCC>GAC	p.A680D	ELMO3_uc002esb.2_Missense_Mutation_p.A663D|ELMO3_uc002esc.2_Missense_Mutation_p.A514D|uc010vjf.1_5'Flank|MIR328_hsa-mir-328|MI0000804_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	627	PH.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		TATGAGTTGGCCTTCTCAATC	0.647000												
MYH10	4628	broad.mit.edu	37	17	8390909	8390909	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr17:8390909G>A	uc002gll.2	-	34	4891	c.4795C>T	c.(4795-4797)CGG>TGG	p.R1599W	MYH10_uc002glm.2_Missense_Mutation_p.R1630W|MYH10_uc010cnx.2_Missense_Mutation_p.R1608W	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1599	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TCGAGCTCCCGCACCTAATGG	0.547000												
MYH10	4628	broad.mit.edu	37	17	8508154	8508154	+	Silent	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr17:8508154G>A	uc002gll.2	-	3	588	c.492C>T	c.(490-492)TGC>TGT	p.C164C	MYH10_uc002glm.2_Silent_p.C164C|MYH10_uc010cnx.2_Silent_p.C164C	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	164	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CTTGAAGCATGCATCTGTAAG	0.313000												
TBX21	30009	broad.mit.edu	37	17	45822578	45822578	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr17:45822578C>T	uc002ilv.1	+	6	1665	c.1454C>T	c.(1453-1455)CCG>CTG	p.P485L		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	485					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						CCCATCCGGCCGGAATCCAGT	0.657000												
ITGA3	3675	broad.mit.edu	37	17	48155636	48155636	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr17:48155636C>T	uc010dbl.2	+	18	2749	c.2285C>T	c.(2284-2286)ACC>ATC	p.T762I	ITGA3_uc010dbm.2_Missense_Mutation_p.T762I	NM_002204	NP_002195	P26006	ITA3_HUMAN	integrin alpha 3 isoform a precursor	762	Extracellular (Potential).				blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			ovary(2)|pancreas(1)	3						ACACTCCAGACCTCGCTTAGC	0.577000												
CDH2	1000	broad.mit.edu	37	18	25573520	25573520	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr18:25573520C>T	uc002kwg.2	-	8	1561	c.1102G>A	c.(1102-1104)GCC>ACC	p.A368T	CDH2_uc010xbn.1_Missense_Mutation_p.A337T	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	368	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GTGATGACGGCCGTGGCTGTG	0.438000												
NFATC1	4772	broad.mit.edu	37	18	77246937	77246937	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr18:77246937G>A	uc010xfg.1	+	9	3235	c.2782G>A	c.(2782-2784)GTA>ATA	p.V928I	NFATC1_uc002lnd.2_Intron|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Missense_Mutation_p.V456I|NFATC1_uc002lnf.2_Missense_Mutation_p.V915I|NFATC1_uc002lng.2_Intron|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	928	Nuclear export signal.|Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CCTGGATGACGGTGAGTGCCC	0.617000												
ELAVL1	1994	broad.mit.edu	37	19	8028580	8028580	+	Silent	SNP	G	G	A	rs145371492	by1000genomes	TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr19:8028580G>A	uc002mjb.2	-	6	935	c.768C>T	c.(766-768)GAC>GAT	p.D256D		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	256	RRM 3.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						GGATCCCCTCGTCGGCATCCT	0.572000												
MUC16	94025	broad.mit.edu	37	19	9047614	9047614	+	Missense_Mutation	SNP	C	C	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr19:9047614C>A	uc002mkp.2	-	5	34221	c.34017G>T	c.(34015-34017)GAG>GAT	p.E11339D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11341	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CATGTGGGGACTCAGGCACTG	0.483000												
ZNF823	55552	broad.mit.edu	37	19	11832637	11832637	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr19:11832637C>T	uc002msm.2	-	4	1838	c.1712G>A	c.(1711-1713)CGA>CAA	p.R571Q	ZNF823_uc010xmd.1_Missense_Mutation_p.R389Q|ZNF823_uc010dyi.1_Missense_Mutation_p.R527Q	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	571	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TTCATGTCCTCGAAGGAAACG	0.433000										HNSCC(68;0.2)		
LRRC4B	94030	broad.mit.edu	37	19	51021776	51021776	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr19:51021776C>T	uc002pss.2	-	3	1331	c.1194G>A	c.(1192-1194)ACG>ACA	p.T398T		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	398	Extracellular (Potential).|Ig-like C2-type.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		TGCCGTTGGGCGTCAGCCAGT	0.647000												
NLRP5	126206	broad.mit.edu	37	19	56552381	56552381	+	Missense_Mutation	SNP	C	C	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr19:56552381C>A	uc002qmj.2	+	11	2880	c.2880C>A	c.(2878-2880)AAC>AAA	p.N960K	NLRP5_uc002qmi.2_Missense_Mutation_p.N941K	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	960	LRR 8.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCCTATCCAACAACAGCCTGG	0.577000												
PRKCE	5581	broad.mit.edu	37	2	46203682	46203682	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr2:46203682A>G	uc002rut.2	+	3	724	c.527A>G	c.(526-528)TAT>TGT	p.Y176C		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	176	Phorbol-ester/DAG-type 1.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			ATGGCCACCTATCTTCGGCAG	0.562000												
DNAH7	56171	broad.mit.edu	37	2	196765097	196765097	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr2:196765097C>T	uc002utj.3	-	28	4558	c.4457G>A	c.(4456-4458)CGC>CAC	p.R1486H		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1486	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGAACACAAGCGATACGTAGC	0.458000												
BMPR2	659	broad.mit.edu	37	2	203378463	203378463	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr2:203378463G>A	uc002uzf.3	+	4	1588	c.440G>A	c.(439-441)CGA>CAA	p.R147Q	BMPR2_uc010ftr.2_Missense_Mutation_p.R147Q	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	147	Extracellular (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						TCATTTAACCGAGATGAGACA	0.259000												
GPBAR1	151306	broad.mit.edu	37	2	219128380	219128380	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr2:219128380C>T	uc010zjw.1	+	2	1180	c.933C>T	c.(931-933)CCC>CCT	p.P311P	GPBAR1_uc010zjx.1_Silent_p.P311P|GPBAR1_uc010zjy.1_Silent_p.P311P	NM_170699	NP_733800	Q8TDU6	GPBAR_HUMAN	G protein-coupled bile acid receptor 1	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;7.19e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGACAGTCCCGGCCCCAGCA	0.642000												
ZNF142	7701	broad.mit.edu	37	2	219508125	219508125	+	Silent	SNP	G	G	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr2:219508125G>C	uc002vin.2	-	8	3550	c.3114C>G	c.(3112-3114)CTC>CTG	p.L1038L	ZNF142_uc002vil.2_Silent_p.L999L|ZNF142_uc010fvt.2_Silent_p.L875L|ZNF142_uc002vim.2_Silent_p.L875L	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1038					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TAATAGAGGAGAGCCGGGAAC	0.607000												
TRIP12	9320	broad.mit.edu	37	2	230670450	230670450	+	Silent	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr2:230670450G>A	uc002vpw.1	-	17	2530	c.2421C>T	c.(2419-2421)AAC>AAT	p.N807N	TRIP12_uc002vpx.1_Silent_p.N855N|TRIP12_uc002vpy.1_Silent_p.N537N|TRIP12_uc010zlz.1_Intron	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	807	WWE.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		ACTTACTAGTGTTACTATTGG	0.318000												
PER2	8864	broad.mit.edu	37	2	239169471	239169471	+	Missense_Mutation	SNP	C	C	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr2:239169471C>A	uc002vyc.2	-	13	1777	c.1540G>T	c.(1540-1542)GCC>TCC	p.A514S	PER2_uc010znv.1_Missense_Mutation_p.A514S	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	514					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		AGACGTACGGCTCTCCTCCGG	0.567000												
PREX1	57580	broad.mit.edu	37	20	47276504	47276504	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr20:47276504G>A	uc002xtw.1	-	16	1857	c.1834C>T	c.(1834-1836)CGC>TGC	p.R612C		NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	612					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AAGTCGTTGCGAAGCTGTTTG	0.577000												
APP	351	broad.mit.edu	37	21	27372462	27372462	+	Silent	SNP	G	G	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr21:27372462G>T	uc002ylz.2	-	7	1101	c.901C>A	c.(901-903)CGA>AGA	p.R301R	APP_uc010glk.2_Silent_p.R296R|APP_uc002yma.2_Silent_p.R301R|APP_uc011ach.1_Silent_p.R245R|APP_uc002ymb.2_Intron|APP_uc010glj.2_Intron|APP_uc011aci.1_Intron	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	301	Extracellular (Potential).|BPTI/Kunitz inhibitor.	Reactive bond.			adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				ATCATTGCTCGGCACGGCCCC	0.517000												
GRIK1	2897	broad.mit.edu	37	21	31015233	31015233	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr21:31015233C>T	uc002yno.1	-	7	1475	c.1011G>A	c.(1009-1011)CGG>CGA	p.R337R	GRIK1_uc002ynn.2_Silent_p.R337R|GRIK1_uc011acs.1_Silent_p.R337R|GRIK1_uc011act.1_Silent_p.R281R|GRIK1_uc010glq.1_Silent_p.R195R|GRIK1_uc002ynr.2_Silent_p.R337R	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	337	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GCTGGGATGCCCGGTGCGAGG	0.532000												
KLHL22	84861	broad.mit.edu	37	22	20819530	20819530	+	Missense_Mutation	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr22:20819530T>C	uc002zsl.1	-	4	836	c.727A>G	c.(727-729)ACA>GCA	p.T243A	KLHL22_uc011ahr.1_Missense_Mutation_p.T100A|KLHL22_uc002zsm.1_Missense_Mutation_p.T243A	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	243					cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AACCGCACTGTCTCAAGGAGC	0.602000												
GGT5	2687	broad.mit.edu	37	22	24621533	24621533	+	Silent	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr22:24621533G>A	uc002zzo.3	-	9	1734	c.1317C>T	c.(1315-1317)TCC>TCT	p.S439S	GGT5_uc002zzp.3_Silent_p.S439S|GGT5_uc002zzr.3_Silent_p.S407S|GGT5_uc002zzq.3_Silent_p.S407S|GGT5_uc011ajm.1_Silent_p.S362S	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	439	Extracellular (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						GGGTGGTGCCGGAACCCCGGG	0.647000												
APOL6	80830	broad.mit.edu	37	22	36054692	36054692	+	Silent	SNP	C	C	T	rs140682432		TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr22:36054692C>T	uc003aoe.2	+	3	375	c.81C>T	c.(79-81)GAC>GAT	p.D27D	APOL6_uc003aod.2_RNA	NM_030641	NP_085144	Q9BWW8	APOL6_HUMAN	apolipoprotein L6	27					lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity				0						TGTGTGAAGACGTGGAGCTAC	0.438000												
CNTN4	152330	broad.mit.edu	37	3	3085346	3085346	+	Missense_Mutation	SNP	A	A	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr3:3085346A>C	uc003bpc.2	+	22	2990	c.2769A>C	c.(2767-2769)CAA>CAC	p.Q923H	CNTN4_uc003bpe.2_Missense_Mutation_p.Q595H|CNTN4_uc003bpf.2_Missense_Mutation_p.Q594H|CNTN4_uc003bpg.2_Missense_Mutation_p.Q179H	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	923	Fibronectin type-III 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ATTGGGATCAAGTGAAGGCCC	0.413000												
TADA3	10474	broad.mit.edu	37	3	9832967	9832967	+	Missense_Mutation	SNP	G	G	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr3:9832967G>C	uc003bsx.1	-	2	732	c.184C>G	c.(184-186)CGT>GGT	p.R62G	TADA3_uc010hcn.1_Missense_Mutation_p.R62G|TADA3_uc003bsy.2_Missense_Mutation_p.R62G|ARPC4_uc003bsz.1_5'Flank|ARPC4_uc003bta.1_5'Flank|ARPC4_uc003btb.1_5'Flank|ARPC4_uc003btc.1_5'Flank	NM_006354	NP_006345	O75528	TADA3_HUMAN	transcriptional adaptor 3 isoform a	62	Potential.				estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity				0						TCAAGCACACGCAGGCGCCGG	0.602000												
ATP2B2	491	broad.mit.edu	37	3	10387238	10387238	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr3:10387238C>T	uc003bvt.2	-	18	2972	c.2533G>A	c.(2533-2535)GCC>ACC	p.A845T	ATP2B2_uc003bvv.2_Missense_Mutation_p.A800T|ATP2B2_uc003bvw.2_Missense_Mutation_p.A800T|ATP2B2_uc010hdo.2_Missense_Mutation_p.A550T	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	845	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GCCTCCTTGGCCACGTCAGTG	0.592000												
KIF15	56992	broad.mit.edu	37	3	44879787	44879787	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr3:44879787C>T	uc003cnx.3	+	27	3341	c.3192C>T	c.(3190-3192)GAC>GAT	p.D1064D	KIF15_uc010hiq.2_Silent_p.D967D|KIF15_uc010hir.2_Silent_p.D112D	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15	1064	Potential.				blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		TCTGTGAGGACCTGGCTCATG	0.453000												
NIT2	56954	broad.mit.edu	37	3	100058731	100058731	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr3:100058731C>T	uc003dtv.2	+	3	273	c.199C>T	c.(199-201)CAG>TAG	p.Q67*	NIT2_uc011bha.1_Nonsense_Mutation_p.Q67*	NM_020202	NP_064587	Q9NQR4	NIT2_HUMAN	nitrilase family, member 2	67	CN hydrolase.				nitrogen compound metabolic process		omega-amidase activity			ovary(1)	1						TGAATCCACACAGAAGCTTTC	0.353000												
HCLS1	3059	broad.mit.edu	37	3	121350700	121350700	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr3:121350700A>G	uc003eeh.3	-	14	1579	c.1454T>C	c.(1453-1455)CTG>CCG	p.L485P	HCLS1_uc011bjj.1_Missense_Mutation_p.L448P	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	485	SH3.				erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		TAGTCACTCCAGAAGCTTGAC	0.527000												
DBR1	51163	broad.mit.edu	37	3	137892448	137892448	+	Missense_Mutation	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr3:137892448T>C	uc003erv.2	-	2	354	c.218A>G	c.(217-219)AAG>AGG	p.K73R	DBR1_uc003eru.2_Missense_Mutation_p.K22R	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	73						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						AACTGGAGCCTTTTTCTCTCC	0.398000												
SLIT2	9353	broad.mit.edu	37	4	20533667	20533667	+	Silent	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr4:20533667T>C	uc003gpr.1	+	17	1878	c.1674T>C	c.(1672-1674)CCT>CCC	p.P558P	SLIT2_uc003gps.1_Silent_p.P550P	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	558					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGAAACTTCCTCAATTACGTA	0.294000												
ANKRD17	26057	broad.mit.edu	37	4	73957913	73957913	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr4:73957913C>T	uc003hgp.2	-	29	5549	c.5432G>A	c.(5431-5433)AGC>AAC	p.S1811N	ANKRD17_uc003hgo.2_Missense_Mutation_p.S1698N|ANKRD17_uc003hgq.2_Missense_Mutation_p.S1560N|ANKRD17_uc003hgr.2_Missense_Mutation_p.S1810N	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1811					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGCTGAGGAGCTTTTCAAACG	0.388000												
FRG2	448831	broad.mit.edu	37	4	190947541	190947541	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr4:190947541G>T	uc003izv.2	-	3	382	c.329C>A	c.(328-330)GCA>GAA	p.A110E	FRG2_uc011clh.1_Missense_Mutation_p.A111E	NM_001005217	NP_001005217	Q64ET8	FRG2_HUMAN	FSHD region gene 2	110						nucleus				ovary(1)	1		all_cancers(14;1.01e-50)|all_epithelial(14;6.7e-35)|all_lung(41;2.17e-14)|Lung NSC(41;4.95e-14)|Breast(6;3.4e-05)|Melanoma(20;0.000539)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|all_hematologic(60;0.0489)|Prostate(90;0.0513)		all cancers(3;3.83e-31)|Epithelial(3;1.36e-30)|OV - Ovarian serous cystadenocarcinoma(60;1.99e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00831)|READ - Rectum adenocarcinoma(43;0.155)		GATTCTACCTGCTGTGTCTTG	0.428000												
BDP1	55814	broad.mit.edu	37	5	70763277	70763277	+	Missense_Mutation	SNP	T	T	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr5:70763277T>A	uc003kbp.1	+	6	1145	c.882T>A	c.(880-882)TTT>TTA	p.F294L	BDP1_uc003kbn.1_Missense_Mutation_p.F294L|BDP1_uc003kbo.2_Missense_Mutation_p.F294L	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	294	Interaction with ZBTB43.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ACTCCAGCTTTAGGAAAAACT	0.323000												
IL3	3562	broad.mit.edu	37	5	131398068	131398068	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr5:131398068G>A	uc003kwe.1	+	3	321	c.268G>A	c.(268-270)GCA>ACA	p.A90T		NM_000588	NP_000579	P08700	IL3_HUMAN	interleukin 3 precursor	90					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			ovary(2)|central_nervous_system(1)	3		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	TTTACAGAACGCATCAGCAAT	0.512000												
PCDHA4	56144	broad.mit.edu	37	5	140188293	140188293	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr5:140188293C>T	uc003lhi.2	+	1	1622	c.1521C>T	c.(1519-1521)TAC>TAT	p.Y507Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.Y507Y|PCDHA4_uc011daa.1_Silent_p.Y507Y	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	507	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCGAGCTACGTTTCGGTGC	0.662000												
PCDHB6	56130	broad.mit.edu	37	5	140531925	140531925	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr5:140531925C>T	uc003lir.2	+	1	2087	c.2087C>T	c.(2086-2088)TCG>TTG	p.S696L	PCDHB6_uc011dah.1_Missense_Mutation_p.S560L	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	696	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCTCGGTGTCGTCGCTCTTC	0.697000												
PCDH1	5097	broad.mit.edu	37	5	141243883	141243883	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr5:141243883C>T	uc003llq.2	-	3	2130	c.2013G>A	c.(2011-2013)CTG>CTA	p.L671L	PCDH1_uc003llp.2_Silent_p.L671L|PCDH1_uc011dbf.1_Silent_p.L649L	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	671	Extracellular (Potential).|Cadherin 6.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GATCAAAGCTCAGGCTGGATA	0.547000												
C1QTNF2	114898	broad.mit.edu	37	5	159776736	159776736	+	Silent	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr5:159776736G>A	uc003lyd.2	-	3	436	c.432C>T	c.(430-432)GCC>GCT	p.A144A		NM_031908	NP_114114	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	99	Collagen-like.					collagen				skin(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAATGGCCCCGGCTTTGCCCT	0.657000												
UNC5A	90249	broad.mit.edu	37	5	176304597	176304597	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr5:176304597G>A	uc003mey.2	+	10	1720	c.1528G>A	c.(1528-1530)GTC>ATC	p.V510I		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	510	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCCCCTGGCGTCCTGCTCAC	0.627000												
MBOAT1	154141	broad.mit.edu	37	6	20124775	20124775	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr6:20124775C>T	uc003ncx.1	-	8	976	c.771G>A	c.(769-771)ACG>ACA	p.T257T	MBOAT1_uc011dji.1_Silent_p.T108T	NM_001080480	NP_001073949	Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain	257	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			TCTTCGTTAGCGTCAAAAACA	0.478000												
BTN2A2	10385	broad.mit.edu	37	6	26388369	26388369	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr6:26388369C>T	uc003nhq.2	+	4	657	c.571C>T	c.(571-573)CCC>TCC	p.P191S	BTN2A2_uc011dkf.1_Missense_Mutation_p.P75S|BTN2A2_uc011dkg.1_Intron|BTN2A2_uc003nhr.2_Missense_Mutation_p.P75S|BTN2A2_uc011dkh.1_Intron|BTN2A2_uc003nhs.2_Missense_Mutation_p.P191S|BTN2A2_uc003nht.2_Missense_Mutation_p.P191S|BTN2A2_uc011dki.1_5'Flank	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	191	Extracellular (Potential).|Ig-like C2-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						TGAGGTTGTGCCCGCCCTGAA	0.577000												
OR12D3	81797	broad.mit.edu	37	6	29342887	29342887	+	Missense_Mutation	SNP	A	A	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr6:29342887A>C	uc003nme.2	-	1	182	c.178T>G	c.(178-180)TTT>GTT	p.F60V		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D,	60	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3						TTTCCCAGAAAAAAATACATA	0.398000												
BAT2	7916	broad.mit.edu	37	6	31604895	31604895	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr6:31604895G>A	uc003nvb.3	+	29	6473	c.6224G>A	c.(6223-6225)CGG>CAG	p.R2075Q	BAT2_uc003nvc.3_Missense_Mutation_p.R2075Q	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	2075	3-3.|3 X 50 AA type C repeats.					cytoplasm|nucleus	protein binding				0						GGATCATCACGGACTCCCCCA	0.502000												
CNR1	1268	broad.mit.edu	37	6	88854343	88854343	+	Silent	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr6:88854343G>A	uc011dzq.1	-	2	4214	c.651C>T	c.(649-651)TCC>TCT	p.S217S	CNR1_uc010kbz.2_Silent_p.S217S|CNR1_uc011dzr.1_Silent_p.S217S|CNR1_uc011dzs.1_Silent_p.S217S|CNR1_uc003pmq.3_Silent_p.S217S|CNR1_uc011dzt.1_Silent_p.S217S|CNR1_uc010kca.2_Silent_p.S184S	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	217	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GCCTGTGAATGGATATGTACC	0.577000												
MLLT4	4301	broad.mit.edu	37	6	168299060	168299060	+	Missense_Mutation	SNP	A	A	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr6:168299060A>C	uc003qwd.2	+	11	1632	c.1490A>C	c.(1489-1491)AAG>ACG	p.K497T	MLLT4_uc003qwb.1_Missense_Mutation_p.K482T|MLLT4_uc003qwc.1_Missense_Mutation_p.K498T|MLLT4_uc003qwf.2_Missense_Mutation_p.K183T	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	498					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CATGTATTTAAGTTTGTGGAC	0.488000			T	MLL	AL							
COL28A1	340267	broad.mit.edu	37	7	7421221	7421221	+	Missense_Mutation	SNP	A	A	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr7:7421221A>T	uc003src.1	-	28	2276	c.2159T>A	c.(2158-2160)TTC>TAC	p.F720Y	COL28A1_uc011jxe.1_Missense_Mutation_p.F403Y	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	720					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TGGGCCTGGGAAGCCTTGTGG	0.473000												
AGR3	155465	broad.mit.edu	37	7	16900174	16900174	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr7:16900174C>T	uc003sts.2	-	7	474	c.401G>A	c.(400-402)GGA>GAA	p.G134E		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	134						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		AGAGTATCTTCCAGCTATGTC	0.378000												
KBTBD2	25948	broad.mit.edu	37	7	32910203	32910203	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr7:32910203C>T	uc003tdb.2	-	4	1285	c.626G>A	c.(625-627)CGA>CAA	p.R209Q	AVL9_uc011kai.1_Intron	NM_015483	NP_056298	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	209											0			GBM - Glioblastoma multiforme(11;0.0499)			ATACTGGGATCGTGATTCTGT	0.398000												
CLIP2	7461	broad.mit.edu	37	7	73753314	73753314	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr7:73753314C>T	uc003uam.2	+	3	985	c.658C>T	c.(658-660)CGC>TGC	p.R220C	CLIP2_uc003uan.2_Missense_Mutation_p.R220C	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	220						microtubule associated complex				skin(3)	3						AAAGGACCTGCGCCTGGGGGA	0.672000												
PCLO	27445	broad.mit.edu	37	7	82582923	82582923	+	Missense_Mutation	SNP	A	A	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr7:82582923A>C	uc003uhx.2	-	5	7635	c.7346T>G	c.(7345-7347)GTG>GGG	p.V2449G	PCLO_uc003uhv.2_Missense_Mutation_p.V2449G|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2380	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGCTGTAGTCACTGGAGATGC	0.308000												
GNGT1	2792	broad.mit.edu	37	7	93536131	93536131	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr7:93536131G>T	uc003unc.1	+	2	221	c.73G>T	c.(73-75)GAA>TAA	p.E25*	GNGT1_uc003umx.1_RNA	NM_021955	NP_068774	P63211	GBG1_HUMAN	guanine nucleotide binding protein (G protein),	25					G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|signal transducer activity				0	all_cancers(62;2.39e-10)|all_epithelial(64;1.54e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			GCTCAAGAAAGAAGTGACACT	0.388000												
SND1	27044	broad.mit.edu	37	7	127725833	127725833	+	Splice_Site	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr7:127725833G>A	uc003vmi.2	+	20	2530	c.2304_splice	c.e20+1	p.N768_splice	SND1_uc010lle.2_Splice_Site_p.N421_splice	NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1						gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						CTACGGCAACGTGAGTGTTGG	0.517000												
OPN1SW	611	broad.mit.edu	37	7	128412618	128412618	+	Silent	SNP	C	C	T	rs140568559	byFrequency	TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr7:128412618C>T	uc003vnt.3	-	5	1023	c.1023G>A	c.(1021-1023)TCG>TCA	p.S341S		NM_001708	NP_001699	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	341	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0						CTTGGGTAGACGAGACAGTAG	0.443000												
RP1L1	94137	broad.mit.edu	37	8	10468213	10468213	+	Missense_Mutation	SNP	A	A	G			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:10468213A>G	uc003wtc.2	-	4	3624	c.3395T>C	c.(3394-3396)CTT>CCT	p.L1132P		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1132					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGGAGACCCAAGGTCTTCCTC	0.587000												
NRG1	3084	broad.mit.edu	37	8	32617821	32617821	+	Silent	SNP	A	A	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:32617821A>C	uc003xiv.2	+	11	1682	c.1165A>C	c.(1165-1167)AGA>CGA	p.R389R	NRG1_uc011lbf.1_Silent_p.R386R|NRG1_uc010lvo.2_Silent_p.R386R|NRG1_uc003xiu.2_Silent_p.R394R|NRG1_uc003xiw.2_Silent_p.R386R|NRG1_uc003xit.2_Silent_p.R389R|NRG1_uc010lvr.2_Silent_p.R131R|NRG1_uc010lvs.2_Silent_p.R131R|NRG1_uc010lvp.2_Silent_p.R343R|NRG1_uc010lvq.2_Silent_p.R326R|NRG1_uc011lbg.1_Silent_p.R235R|NRG1_uc011lbh.1_Silent_p.R232R|NRG1_uc003xja.2_Silent_p.R200R	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	389	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGGGGGCCCAAGAGGACGTCT	0.527000												
AP3M2	10947	broad.mit.edu	37	8	42012342	42012342	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:42012342C>T	uc003xop.2	+	3	428	c.137C>T	c.(136-138)CCT>CTT	p.P46L	AP3M2_uc003xoo.2_Missense_Mutation_p.P46L|AP3M2_uc010lxe.2_RNA|AP3M2_uc003xoq.1_5'UTR|AP3M2_uc003xor.1_Missense_Mutation_p.P46L	NM_001134296	NP_001127768	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	46					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus					0	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GAAAATGTGCCTCCGGTTATC	0.483000												
PXDNL	137902	broad.mit.edu	37	8	52321476	52321476	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:52321476G>A	uc003xqu.3	-	17	2809	c.2708C>T	c.(2707-2709)TCG>TTG	p.S903L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	903					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTCCCGCTCCGAGCTCCCGTA	0.597000												
PCMTD1	115294	broad.mit.edu	37	8	52773689	52773690	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:52773689_52773690CC>AA	uc003xqx.3	-	2	363_364	c.22_23GG>TT	c.(22-24)GGG>TTG	p.G8L	PCMTD1_uc003xqw.3_Missense_Mutation_p.G8L|PCMTD1_uc011ldn.1_Intron|PCMTD1_uc010lya.2_Intron|PCMTD1_uc011ldo.1_Missense_Mutation_p.G8L	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	8						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				ATTATCTTCCCCAGCACTCACA	0.347000												
PREX2	80243	broad.mit.edu	37	8	69032431	69032431	+	Missense_Mutation	SNP	G	G	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:69032431G>T	uc003xxv.1	+	29	3532	c.3505G>T	c.(3505-3507)GTG>TTG	p.V1169L		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1169					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CTATTGATAGGTGGATTCAAT	0.368000												
TM7SF4	81501	broad.mit.edu	37	8	105368424	105368424	+	Nonstop_Mutation	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:105368424T>C	uc003ylx.1	+	4	1460	c.1411T>C	c.(1411-1413)TGA>CGA	p.*471R		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	471					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AGACAAGTCATGAGAGACCCC	0.448000												
CSMD3	114788	broad.mit.edu	37	8	113256718	113256718	+	Missense_Mutation	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:113256718T>C	uc003ynu.2	-	65	10466	c.10307A>G	c.(10306-10308)TAT>TGT	p.Y3436C	CSMD3_uc003yns.2_Missense_Mutation_p.Y2638C|CSMD3_uc003ynt.2_Missense_Mutation_p.Y3396C|CSMD3_uc011lhx.1_Missense_Mutation_p.Y3267C	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3436	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTGACAGGTATAAATCAGTGT	0.443000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
COL14A1	7373	broad.mit.edu	37	8	121222070	121222070	+	Missense_Mutation	SNP	T	T	C			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr8:121222070T>C	uc003yox.2	+	12	1662	c.1397T>C	c.(1396-1398)GTG>GCG	p.V466A	COL14A1_uc003yoy.2_Missense_Mutation_p.V144A|COL14A1_uc010mde.1_Missense_Mutation_p.V144A	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	466	Fibronectin type-III 3.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TGGGATGCAGTGCCTGGGGCC	0.473000												
KIAA1797	54914	broad.mit.edu	37	9	20720434	20720434	+	Missense_Mutation	SNP	G	G	A	rs143009945		TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr9:20720434G>A	uc003zog.1	+	6	551	c.188G>A	c.(187-189)CGA>CAA	p.R63Q		NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	63						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		GTAGTGGTTCGAACAGCCTGC	0.468000												
SLC35D2	11046	broad.mit.edu	37	9	99086398	99086398	+	Missense_Mutation	SNP	G	G	T	rs145290742		TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr9:99086398G>T	uc004awc.2	-	10	882	c.806C>A	c.(805-807)ACG>AAG	p.T269K	SLC35D2_uc010msd.2_RNA|SLC35D2_uc010mse.2_Missense_Mutation_p.T222K|SLC35D2_uc010msf.2_Missense_Mutation_p.T181K|SLC35D2_uc004awd.2_Missense_Mutation_p.D111E	NM_007001	NP_008932	Q76EJ3	S35D2_HUMAN	solute carrier family 35, member D2	269	Helical; (Potential).					Golgi membrane|integral to membrane	nucleotide-sugar transmembrane transporter activity				0		Acute lymphoblastic leukemia(62;0.0167)				CACTGCTGTCGTCAGGGCTGA	0.512000												
ASTN2	23245	broad.mit.edu	37	9	119380718	119380718	+	Missense_Mutation	SNP	A	A	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr9:119380718A>T	uc004bjs.1	-	19	3341	c.3240T>A	c.(3238-3240)AGT>AGA	p.S1080R	ASTN2_uc004bjr.1_Missense_Mutation_p.S1076R|ASTN2_uc004bjt.1_Missense_Mutation_p.S1029R|ASTN2_uc004bjp.1_Missense_Mutation_p.S173R|ASTN2_uc004bjq.1_Missense_Mutation_p.S132R|ASTN2_uc011lxr.1_Missense_Mutation_p.S132R|ASTN2_uc011lxs.1_Missense_Mutation_p.S132R|ASTN2_uc011lxt.1_Missense_Mutation_p.S132R|ASTN2_uc004bjv.1_Missense_Mutation_p.S132R	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1080	Extracellular (Potential).|Fibronectin type-III.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						AGACCACAGTACTGGAGGGCT	0.527000												
SETX	23064	broad.mit.edu	37	9	135205649	135205649	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr9:135205649G>A	uc004cbk.2	-	10	1519	c.1336C>T	c.(1336-1338)CAA>TAA	p.Q446*	SETX_uc004cbj.2_Nonsense_Mutation_p.Q65*|SETX_uc010mzt.2_Nonsense_Mutation_p.Q65*	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	446					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCATCTGTTTGGTTGAGGACT	0.383000												
CLCN5	1184	broad.mit.edu	37	X	49854898	49854898	+	Missense_Mutation	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chrX:49854898C>T	uc004dos.1	+	10	1908	c.1660C>T	c.(1660-1662)CGG>TGG	p.R554W	CLCN5_uc004dor.1_Missense_Mutation_p.R624W|CLCN5_uc004doq.1_Missense_Mutation_p.R624W|CLCN5_uc004dot.1_Missense_Mutation_p.R554W	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	554	Cytoplasmic (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					TGCTCTTGGGCGGGAGGGCAT	0.488000												
ZCCHC5	203430	broad.mit.edu	37	X	77912678	77912678	+	Missense_Mutation	SNP	T	T	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chrX:77912678T>A	uc004edc.1	-	2	1536	c.1240A>T	c.(1240-1242)AGT>TGT	p.S414C		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	414							nucleic acid binding|zinc ion binding			ovary(1)	1						GCTGGTGGACTCTCGGGTCCA	0.517000												
BRWD3	254065	broad.mit.edu	37	X	79932138	79932138	+	Silent	SNP	C	C	T			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chrX:79932138C>T	uc004edt.2	-	41	5642	c.5379G>A	c.(5377-5379)AGG>AGA	p.R1793R	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Silent_p.R1389R|BRWD3_uc004edp.2_Silent_p.R1622R|BRWD3_uc004edq.2_Silent_p.R1389R|BRWD3_uc010nmj.1_Silent_p.R1389R|BRWD3_uc004edr.2_Silent_p.R1463R|BRWD3_uc004eds.2_Silent_p.R1389R|BRWD3_uc004edu.2_Silent_p.R1463R|BRWD3_uc004edv.2_Silent_p.R1389R|BRWD3_uc004edw.2_Silent_p.R1389R|BRWD3_uc004edx.2_Silent_p.R1389R|BRWD3_uc004edy.2_Silent_p.R1389R|BRWD3_uc004edz.2_Silent_p.R1463R|BRWD3_uc004eea.2_Silent_p.R1463R|BRWD3_uc004eeb.2_Silent_p.R1389R|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1793										ovary(4)	4						GATGGCTAACCCTGGCTTTTT	0.368000												
GPR112	139378	broad.mit.edu	37	X	135455081	135455081	+	Missense_Mutation	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chrX:135455081G>A	uc004ezu.1	+	15	7925	c.7634G>A	c.(7633-7635)CGT>CAT	p.R2545H	GPR112_uc010nsb.1_Missense_Mutation_p.R2340H	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2545	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ATAATTGAGCGTACTGGTCAC	0.488000												
G6PD	2539	broad.mit.edu	37	X	153760800	153760800	+	Silent	SNP	G	G	A			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chrX:153760800G>A	uc004fly.1	-	10	1382	c.1269C>T	c.(1267-1269)ACC>ACT	p.T423T	G6PD_uc004flx.1_Silent_p.T453T	NM_001042351	NP_001035810	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase isoform b	423					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGTTGCCGTAGGTCAGGTCCA	0.622000												
PCDH1	5097	broad.mit.edu	37	5	141244796	141244796	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CG-5734-01A-11D-1600-08	TCGA-CG-5734-11A-01D-1600-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fcf304f6-27f0-4e97-a070-78478cfb3f71	660f9d0f-0fc5-4eb7-b45e-561e05600357	g.chr5:141244795_141244795CT>C	uc003llp.3	-	2	1218	c.1101_1101AG>G	c.(1099-1101)aagfs	p.K367fs	PCDH1_uc011dbf.2_Frame_Shift_Del_p.K345fs|PCDH1_uc003llq.3_Frame_Shift_Del_p.K367fs	NM_032420	NP_115796	Q08174	PCDH1_HUMAN	Homo sapiens protocadherin 1 (PCDH1), transcript variant 2, mRNA.	367	Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CACGGGCACTCTTGGGGTTGG	0.577