Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
FAM5B	57795	broad.mit.edu	37	1	177245464	177245464	+	Silent	SNP	C	C	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr1:177245464C>A	uc001glf.2	+	6	1218	c.906C>A	c.(904-906)ACC>ACA	p.T302T	FAM5B_uc010pna.1_Silent_p.T52T|FAM5B_uc001glg.2_Silent_p.T197T	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	302						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						GCAGCCCCACCTTCCCTGAAT	0.577000												
RBP3	5949	broad.mit.edu	37	10	48388390	48388390	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr10:48388390C>T	uc001jez.2	-	1	2602	c.2488G>A	c.(2488-2490)GCC>ACC	p.A830T		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	830	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CGCTGGCCGGCGACCTGGGGC	0.607000												
BRSK2	9024	broad.mit.edu	37	11	1472605	1472605	+	Silent	SNP	G	G	A	rs3793971		TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr11:1472605G>A	uc001lti.2	+	15	1886	c.1500G>A	c.(1498-1500)CCG>CCA	p.P500P	BRSK2_uc009ycv.1_Silent_p.P522P|BRSK2_uc001lth.1_Silent_p.P500P|BRSK2_uc001ltj.2_Silent_p.P500P|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Silent_p.P500P|BRSK2_uc001ltm.2_Silent_p.P546P|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA|BRSK2_uc009ycw.2_5'UTR	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	500					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		GCACAGTTCCGACGCCGGAGG	0.637000												
SERPING1	710	broad.mit.edu	37	11	57381843	57381843	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr11:57381843C>A	uc001nkp.1	+	8	1483	c.1292C>A	c.(1291-1293)ACA>AAA	p.T431K	SERPING1_uc001nkq.1_Missense_Mutation_p.T394K|SERPING1_uc010rju.1_Missense_Mutation_p.T379K|SERPING1_uc010rjv.1_Missense_Mutation_p.T436K|SERPING1_uc001nkr.1_Missense_Mutation_p.T431K|SERPING1_uc009ymi.1_Missense_Mutation_p.T440K|SERPING1_uc009ymj.1_3'UTR|SERPING1_uc001nks.1_Missense_Mutation_p.T122K	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	431					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						TGTGGGCTGACAGAGGACCCA	0.522000									Hereditary_Angioedema			
ODZ4	26011	broad.mit.edu	37	11	78413143	78413143	+	Silent	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr11:78413143G>A	uc001ozl.3	-	28	4978	c.4515C>T	c.(4513-4515)CTC>CTT	p.L1505L	ODZ4_uc009yvb.1_Silent_p.L89L	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1505	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CCCCAGCAACGAGTGAGATCT	0.473000												
ETNK1	55500	broad.mit.edu	37	12	22796905	22796905	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr12:22796905T>C	uc001rft.2	+	2	654	c.632T>C	c.(631-633)ATA>ACA	p.I211T	ETNK1_uc009ziz.2_Missense_Mutation_p.I211T|ETNK1_uc001rfs.2_Missense_Mutation_p.I211T	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	211					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						TATGAATTTATACAAGGAGAA	0.398000												
ATF7	11016	broad.mit.edu	37	12	53918448	53918448	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr12:53918448T>C	uc001sdy.2	-	9	1079	c.1058A>G	c.(1057-1059)AAC>AGC	p.N353S	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Missense_Mutation_p.N342S|ATF7_uc010sol.1_Missense_Mutation_p.N321S	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	353	Basic motif.|Essential for binding adenovirus 2 E1A.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						TGCAGCCCGGTTGCGCTCCAG	0.607000												
TMX1	81542	broad.mit.edu	37	14	51713861	51713861	+	Silent	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr14:51713861C>T	uc001wza.3	+	4	491	c.366C>T	c.(364-366)GAC>GAT	p.D122D	TMX1_uc010aoa.2_Silent_p.D38D	NM_030755	NP_110382	Q9H3N1	TMX1_HUMAN	thioredoxin domain containing 1 precursor	122	Thioredoxin.|Extracellular (Potential).				anti-apoptosis|cell proliferation|cell redox homeostasis|DNA replication|electron transport chain|ER to Golgi vesicle-mediated transport|leukocyte activation|positive regulation of growth|positive regulation of transcription, DNA-dependent|response to stress|signal transduction	endoplasmic reticulum membrane|integral to membrane|membrane fraction	arsenate reductase (thioredoxin) activity|disulfide oxidoreductase activity				0						CTAAGAAGGACTTCATAAACT	0.363000												
DLST	1743	broad.mit.edu	37	14	75361090	75361090	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr14:75361090A>G	uc001xqv.2	+	10	811	c.748A>G	c.(748-750)ACT>GCT	p.T250A	DLST_uc001xqu.2_Missense_Mutation_p.T162A|DLST_uc001xqt.2_Missense_Mutation_p.T166A|DLST_uc010tuw.1_Missense_Mutation_p.T164A|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Missense_Mutation_p.T250A	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	250					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		AATGCTGACAACTTTTAATGA	0.468000												
DENND4A	10260	broad.mit.edu	37	15	65989678	65989678	+	Silent	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr15:65989678T>C	uc002aph.2	-	20	3123	c.2745A>G	c.(2743-2745)GAA>GAG	p.E915E	DENND4A_uc002api.2_Silent_p.E958E|DENND4A_uc002apj.3_Silent_p.E915E	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	915					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						CTCTTCTAACTTCATCTTTAG	0.318000												
ADAMTSL3	57188	broad.mit.edu	37	15	84611717	84611717	+	Silent	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr15:84611717G>A	uc002bjz.3	+	19	2597	c.2373G>A	c.(2371-2373)ACG>ACA	p.T791T	ADAMTSL3_uc010bmt.1_Silent_p.T791T|ADAMTSL3_uc010bmu.1_Silent_p.T791T	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	791	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCTGCTAACGGATGGCAGCT	0.547000												
ADAD2	161931	broad.mit.edu	37	16	84228960	84228960	+	Silent	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr16:84228960C>T	uc002fhr.2	+	5	906	c.792C>T	c.(790-792)ACC>ACT	p.T264T	ADAD2_uc002fhq.2_Silent_p.T346T|uc002fhs.1_5'UTR	NM_001145400	NP_001138872	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2 isoform	264	A to I editase.				RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding				0						CTCTGGGCACCGGCAGCAGCT	0.677000												
SLC35B1	10237	broad.mit.edu	37	17	47783608	47783608	+	Silent	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr17:47783608G>A	uc002iph.1	-	3	384	c.297C>T	c.(295-297)GTC>GTT	p.V99V	SLC35B1_uc002ipi.1_Silent_p.V32V|SLC35B1_uc002ipj.1_5'UTR|SLC35B1_uc010wly.1_Silent_p.V99V	NM_005827	NP_005818	P78383	S35B1_HUMAN	solute carrier family 35, member B1	99	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	UDP-galactose transmembrane transporter activity				0						AATTGCTGGAGACCATGGCAC	0.498000												
ATP8B3	148229	broad.mit.edu	37	19	1785587	1785587	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:1785587C>T	uc002ltw.2	-	26	3508	c.3274G>A	c.(3274-3276)GTC>ATC	p.V1092I	ATP8B3_uc002ltv.2_Missense_Mutation_p.V1055I|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1092	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGAAGTTGACCAGAGAGGTG	0.612000												
ZNF567	163081	broad.mit.edu	37	19	37210533	37210533	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:37210533C>T	uc010xtl.1	+	6	1129	c.907C>T	c.(907-909)CAC>TAC	p.H303Y	ZNF567_uc002oeo.1_Missense_Mutation_p.H303Y|ZNF567_uc010xtk.1_Missense_Mutation_p.H303Y|ZNF567_uc002oep.3_Missense_Mutation_p.H272Y|ZNF567_uc002oeq.1_Missense_Mutation_p.H272Y	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	303	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCAGAGAACTCACACAGGAGA	0.423000												
PSG3	5671	broad.mit.edu	37	19	43242982	43242982	+	Silent	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:43242982C>T	uc002oue.2	-	2	456	c.324G>A	c.(322-324)CTG>CTA	p.L108L	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Silent_p.L130L	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	108	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				CATTCTGGATCAGCAGGGATG	0.448000												
SLC8A2	6543	broad.mit.edu	37	19	47969473	47969473	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:47969473G>A	uc002pgx.2	-	2	466	c.188C>T	c.(187-189)CCG>CTG	p.P63L	SLC8A2_uc010xyq.1_Intron|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Missense_Mutation_p.P63L	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	63	Extracellular (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		ACCCAGCGACGGGTCGTCGGG	0.672000												
BIRC8	112401	broad.mit.edu	37	19	53793270	53793270	+	Nonsense_Mutation	SNP	G	G	A	rs113838023	byFrequency	TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:53793270G>A	uc002qbk.2	-	1	1606	c.358C>T	c.(358-360)CGA>TGA	p.R120*		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	120					apoptosis		zinc ion binding	p.R120*(1)		lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		AATCCCATTCGTATAGCTTCT	0.383000												
ZSCAN5B	342933	broad.mit.edu	37	19	56704310	56704310	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:56704310T>A	uc010ygh.1	-	1	112	c.112A>T	c.(112-114)AGG>TGG	p.R38W		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	38					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCAGGGTTCCTGTCGTGATTT	0.562000												
ZSCAN5B	342933	broad.mit.edu	37	19	56704314	56704314	+	Silent	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:56704314G>A	uc010ygh.1	-	1	108	c.108C>T	c.(106-108)CAC>CAT	p.H36H		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	36					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GGTTCCTGTCGTGATTTCCAA	0.562000												
ZNF470	388566	broad.mit.edu	37	19	57089694	57089694	+	Missense_Mutation	SNP	C	C	T	rs143160710		TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:57089694C>T	uc002qnl.3	+	6	2573	c.1897C>T	c.(1897-1899)CGT>TGT	p.R633C	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	633	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		CTTTAGCCATCGTAAATCCCT	0.433000												
HS1BP3	64342	broad.mit.edu	37	2	20840801	20840801	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr2:20840801T>C	uc002rdw.1	-	3	379	c.338A>G	c.(337-339)AAT>AGT	p.N113S	HS1BP3_uc002rdx.2_Missense_Mutation_p.N113S|HS1BP3_uc002rdy.2_Missense_Mutation_p.N113S	NM_022460	NP_071905	Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	113	PX.				cell communication		phosphatidylinositol binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGATCTCATTGAACACGGC	0.582000												
STRN	6801	broad.mit.edu	37	2	37076928	37076928	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr2:37076928G>A	uc002rpn.2	-	17	2111	c.2102C>T	c.(2101-2103)TCG>TTG	p.S701L	STRN_uc010ezx.2_Missense_Mutation_p.S664L	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	701	WD 4.				dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				GGCTACCATCGAGTGGATCAG	0.413000												
C2orf78	388960	broad.mit.edu	37	2	74042710	74042710	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr2:74042710C>T	uc002sjr.1	+	3	1481	c.1360C>T	c.(1360-1362)CCC>TCC	p.P454S		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	454										ovary(2)	2						TACTTACCTCCCCCCGATCTT	0.463000												
CXCR2	3579	broad.mit.edu	37	2	218999840	218999840	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr2:218999840G>A	uc002vgz.1	+	4	541	c.316G>A	c.(316-318)GCC>ACC	p.A106T	CXCR2_uc002vha.1_Missense_Mutation_p.A106T|CXCR2_uc002vhb.1_Missense_Mutation_p.A106T	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	106	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						CATCTGGGCCGCCTCCAAGGT	0.552000												
ATRN	8455	broad.mit.edu	37	20	3541448	3541448	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr20:3541448C>T	uc002wim.2	+	8	1433	c.1343C>T	c.(1342-1344)TCT>TTT	p.S448F	ATRN_uc002wil.2_Missense_Mutation_p.S448F	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	448	Extracellular (Potential).|Kelch 2.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						GTTGGGCACTCTGCACACATT	0.453000												
GDF5	8200	broad.mit.edu	37	20	34021881	34021881	+	Silent	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr20:34021881C>T	uc010gfc.1	-	2	1573	c.1332G>A	c.(1330-1332)ACG>ACA	p.T444T	uc002xcj.2_Missense_Mutation_p.R98C|GDF5_uc002xck.1_Silent_p.T444T|GDF5_uc010zvc.1_Silent_p.T444T	NM_000557	NP_000548	P43026	GDF5_HUMAN	growth differentiation factor 5 preproprotein	444					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity				0	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CTGCATGATTCGTGGGCTCCA	0.612000												
CLDN8	9073	broad.mit.edu	37	21	31587979	31587979	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr21:31587979C>T	uc002ynu.1	-	1	340	c.265G>A	c.(265-267)GTG>ATG	p.V89M		NM_199328	NP_955360	P56748	CLD8_HUMAN	claudin 8	89	Helical; (Potential).				calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						AAGGACATCACGGAAGCAGCA	0.537000												
SAPS2	9701	broad.mit.edu	37	22	50878172	50878172	+	Missense_Mutation	SNP	C	C	T	rs148549099		TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr22:50878172C>T	uc003blb.1	+	21	2593	c.2171C>T	c.(2170-2172)ACG>ATG	p.T724M	SAPS2_uc003bky.1_Missense_Mutation_p.T698M|SAPS2_uc003bkz.1_Missense_Mutation_p.T697M|SAPS2_uc003blc.2_Missense_Mutation_p.T724M|SAPS2_uc003bla.1_Missense_Mutation_p.T698M|SAPS2_uc003bld.1_Missense_Mutation_p.T257M	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	724						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		GCGAACTCAACGCCCACAGCC	0.632000												
AZI2	64343	broad.mit.edu	37	3	28373891	28373891	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr3:28373891T>A	uc003ceb.2	-	6	1148	c.616A>T	c.(616-618)AGC>TGC	p.S206C	AZI2_uc003cec.2_Missense_Mutation_p.S94C|AZI2_uc003ced.2_Missense_Mutation_p.S206C|AZI2_uc003cee.3_Missense_Mutation_p.S206C|AZI2_uc003ceg.2_Missense_Mutation_p.S206C|AZI2_uc011axd.1_Missense_Mutation_p.S206C|AZI2_uc003cef.2_Missense_Mutation_p.S206C	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2 isoform a	206	Interaction with TBK1.					mitochondrion|plasma membrane				ovary(2)	2						AGATCTCTGCTCTTCAGATTG	0.328000												
SNTN	132203	broad.mit.edu	37	3	63649696	63649696	+	Silent	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr3:63649696C>T	uc003dlr.2	+	4	389	c.369C>T	c.(367-369)TTC>TTT	p.F123F		NM_001080537	NP_001074006	A6NMZ2	SNTAN_HUMAN	sentan, cilia apical structure protein	123						cilium	calcium ion binding			ovary(1)	1						TTGAAGACTTCATGATCTTGC	0.338000												
ROBO2	6092	broad.mit.edu	37	3	77526676	77526676	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr3:77526676G>A	uc003dpy.3	+	3	1143	c.500G>A	c.(499-501)TGG>TAG	p.W167*	ROBO2_uc003dpz.2_Nonsense_Mutation_p.W167*|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Nonsense_Mutation_p.W167*	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	167	Ig-like C2-type 2.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ACCATCTACTGGAAAAAAGAC	0.453000												
TFG	10342	broad.mit.edu	37	3	100463762	100463762	+	Silent	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr3:100463762T>C	uc003due.2	+	7	1256	c.807T>C	c.(805-807)GGT>GGC	p.G269G	TFG_uc003duf.2_Silent_p.G269G|TFG_uc003dug.2_Silent_p.G265G|TFG_uc003duh.2_Silent_p.G265G|TFG_uc003dui.2_Silent_p.G269G	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	269					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						AACAGTATGGTATTCAGTATT	0.448000			T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC							
SOX14	8403	broad.mit.edu	37	3	137484052	137484052	+	Silent	SNP	G	G	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr3:137484052G>T	uc003erm.1	+	1	474	c.426G>T	c.(424-426)GCG>GCT	p.A142A		NM_004189	NP_004180	O95416	SOX14_HUMAN	SRY-box 14	142					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding				0						TGGACCCCGCGCAGTTTAGCT	0.716000												
EHHADH	1962	broad.mit.edu	37	3	184966304	184966304	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr3:184966304T>C	uc003fpf.2	-	2	103	c.76A>G	c.(76-78)ACG>GCG	p.T26A	EHHADH_uc011brs.1_5'UTR	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	26	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	AGTAAAGTCGTACTAAAAGAA	0.333000												
EVC2	132884	broad.mit.edu	37	4	5578019	5578019	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr4:5578019G>C	uc003gij.2	-	18	3274	c.3220C>G	c.(3220-3222)CTG>GTG	p.L1074V	EVC2_uc011bwb.1_Missense_Mutation_p.L514V|EVC2_uc003gik.2_Missense_Mutation_p.L994V	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1074	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						GCTTGGTGCAGGACAGTAGAG	0.592000												
APBB2	323	broad.mit.edu	37	4	40824002	40824002	+	Silent	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr4:40824002G>A	uc003gvl.2	-	17	2625	c.1995C>T	c.(1993-1995)GAC>GAT	p.D665D	APBB2_uc010ifu.2_Silent_p.D237D|APBB2_uc003gvm.2_Silent_p.D643D|APBB2_uc003gvn.2_Silent_p.D666D|APBB2_uc003gvk.2_Silent_p.D117D	NM_173075	NP_775098	Q92870	APBB2_HUMAN	amyloid beta A4 precursor protein-binding,	665	PID 2.				cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			ovary(2)|large_intestine(1)	3						ATGTGTGGACGTCCTTCCCAA	0.522000												
TXK	7294	broad.mit.edu	37	4	48116415	48116415	+	Silent	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr4:48116415G>A	uc003gxx.3	-	2	107	c.21C>T	c.(19-21)AAC>AAT	p.N7N	TXK_uc003gxy.1_Silent_p.N7N	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	7						cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						ACTGGATGGTGTTATCTGAAA	0.418000												
C4orf33	132321	broad.mit.edu	37	4	130030829	130030829	+	Splice_Site	SNP	T	T	G			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr4:130030829T>G	uc003igu.3	+	5	858	c.494_splice	c.e5+2	p.F165_splice	C4orf33_uc010ioc.1_Nonstop_Mutation_p.*166E|C4orf33_uc010iod.2_Splice_Site_p.F165_splice	NM_173487	NP_775758	Q8N1A6	CD033_HUMAN	hypothetical protein LOC132321											upper_aerodigestive_tract(1)	1						ACCTGATTTGTAAGTAGAAAA	0.338000												
TTC29	83894	broad.mit.edu	37	4	147724798	147724798	+	Missense_Mutation	SNP	A	A	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr4:147724798A>T	uc003ikw.3	-	11	1368	c.1141T>A	c.(1141-1143)TTT>ATT	p.F381I	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.F407I|TTC29_uc010ipd.1_Missense_Mutation_p.F381I	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	381	TPR 5.						binding				0	all_hematologic(180;0.151)					GTTGTGTCAAAAGCTTGCTGA	0.348000												
CDSN	1041	broad.mit.edu	37	6	31084714	31084714	+	Silent	SNP	G	G	A	rs145637055	byFrequency	TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr6:31084714G>A	uc003nsm.1	-	2	705	c.678C>T	c.(676-678)CCC>CCT	p.P226P	PSORS1C1_uc003nsl.1_Intron|PSORS1C1_uc010jsj.1_Intron	NM_001264	NP_001255	Q15517	CDSN_HUMAN	corneodesmosin precursor	226	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			ovary(1)|pancreas(1)	2						CTCCACTGCAGGGAGAGTCGG	0.627000												
INTS1	26173	broad.mit.edu	37	7	1535799	1535799	+	Silent	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr7:1535799T>C	uc003skn.2	-	12	1805	c.1704A>G	c.(1702-1704)GAA>GAG	p.E568E	INTS1_uc003skp.1_5'Flank	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	568					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		TACTCCTCTTTTCTCCTTTGT	0.652000												
ZAN	7455	broad.mit.edu	37	7	100350373	100350373	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr7:100350373C>T	uc003uwj.2	+	14	2810	c.2645C>T	c.(2644-2646)ACG>ATG	p.T882M	ZAN_uc003uwk.2_Missense_Mutation_p.T882M|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	882	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACCATCCCCACGGAAAAACCC	0.502000												
KCND2	3751	broad.mit.edu	37	7	119914783	119914783	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr7:119914783C>G	uc003vjj.1	+	1	1062	c.97C>G	c.(97-99)CAG>GAG	p.Q33E		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	33	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					TCCCCCGAGGCAGGAGAGGAA	0.627000												
CNOT4	4850	broad.mit.edu	37	7	135079154	135079154	+	Silent	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr7:135079154T>C	uc003vsv.1	-	10	1450	c.1143A>G	c.(1141-1143)GTA>GTG	p.V381V	CNOT4_uc003vss.2_Silent_p.V378V|CNOT4_uc011kpz.1_Silent_p.V378V|CNOT4_uc003vst.2_Silent_p.V381V|CNOT4_uc003vsu.1_Silent_p.V378V|CNOT4_uc011kpy.1_Silent_p.V381V	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	381					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						TAGAGGATGATACTGGGATTG	0.383000												
RP1	6101	broad.mit.edu	37	8	55542840	55542840	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr8:55542840T>C	uc003xsd.1	+	4	6546	c.6398T>C	c.(6397-6399)CTT>CCT	p.L2133P	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	2133					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGTGAAAATCTTTTCATTTGG	0.323000												
ABCA1	19	broad.mit.edu	37	9	107571749	107571749	+	Silent	SNP	G	G	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr9:107571749G>A	uc004bcl.2	-	30	4585	c.4272C>T	c.(4270-4272)ATC>ATT	p.I1424I		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1424	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCACTCACGGGATTGGGTTTC	0.507000												
ZNF157	7712	broad.mit.edu	37	X	47272403	47272403	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chrX:47272403T>A	uc004dhr.1	+	4	1000	c.931T>A	c.(931-933)TTC>ATC	p.F311I		NM_003446	NP_003437	P51786	ZN157_HUMAN	zinc finger protein 157	311	C2H2-type 6.				negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGGGAAAAACTTCCGTGCAAA	0.423000												
CDCP1	64866	broad.mit.edu	37	3	45160116	45160119	+	Splice_Site	DEL	GAAG	GAAG	-			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr3:45160115_45160118TGAAG>T	uc003com.3	-	2	218	c.83_splice	c.e2-1	p.E28_splice	CDCP1_uc003con.3_Splice_Site_p.E28_splice	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	Homo sapiens CUB domain containing protein 1 (CDCP1), transcript variant 1, mRNA.	28						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CAAAAGCTTCTGAAGGAAGGAAGG	0.471												
C11orf2	738	broad.mit.edu	37	11	64863866	64863866	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr11:64863866delG	uc001ocr.1	+	1	184	c.144delG	c.(142-144)GCGfs	p.A48fs		NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	48					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						AAGGGGAGGCGGCGGGACGCC	0.701												
KDM5C	8242	broad.mit.edu	37	X	53228037	53228038	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chrX:53228037_53228038insA	uc004drz.2	-	16	2809_2810	c.2276_2277insT	c.(2275-2277)ATGfs	p.M759fs	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Frame_Shift_Ins_p.M692fs|KDM5C_uc004dsa.2_Frame_Shift_Ins_p.M758fs	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	759					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						GCTTATGCAGCATGGCAGGAAG	0.579			N|F|S		clear cell renal carcinoma							
ATP1A1	476	broad.mit.edu	37	1	116930018	116930019	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr1:116930017_116930018T>TG	uc001ege.3	+	3	630_631	c.291_292T>TG	c.(289-294)tttgggfs	p.F97fs	ATP1A1_uc010owv.1_Frame_Shift_Ins_p.F66fs|ATP1A1_uc010oww.2_Frame_Shift_Ins_p.F97fs|ATP1A1_uc010owx.2_Frame_Shift_Ins_p.F66fs	NM_000701	NP_001153706	P05023	AT1A1_HUMAN	Homo sapiens ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), transcript variant 1, mRNA.	97					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	GGCAGCTCTTTGGGGGGTTCTC	0.510												
OBSCN	84033	broad.mit.edu	37	1	228430943	228430944	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr1:228430942_228430943A>AG	uc009xez.1	+	9	3032_3033	c.2988_2989A>AG	c.(2986-2991)gcagggfs	p.A996fs	OBSCN_uc001hsn.3_Frame_Shift_Ins_p.A996fs	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	996	Ig-like 10.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	M band|Z disc|cytosol	ATP binding|Rho guanyl-nucleotide exchange factor activity|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGCTGAGGCAGGGGCCAGTGC	0.589												
CDCP1	64866	broad.mit.edu	37	3	45160116	45160119	+	Splice_Site	DEL	GAAG	GAAG	-			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr3:45160115_45160118TGAAG>T	uc003com.3	-	2	218	c.83_splice	c.e2-1	p.E28_splice	CDCP1_uc003con.3_Splice_Site_p.E28_splice	NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	Homo sapiens CUB domain containing protein 1 (CDCP1), transcript variant 1, mRNA.	28						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		CAAAAGCTTCTGAAGGAAGGAAGG	0.471												
BZRAP1	9256	broad.mit.edu	37	17	56386384	56386385	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr17:56386383_56386384C>CT	uc002ivx.4	-	21	5120_5121	c.4249_4250G>AG	c.(4249-4251)agcfs	p.S1417fs	BZRAP1_uc002ivw.3_5'Flank|BZRAP1_uc010dcs.3_Frame_Shift_Ins_p.S1357fs|BZRAP1_uc010wnt.2_Frame_Shift_Ins_p.S1417fs	NM_004758	NP_004749	O95153	RIMB1_HUMAN	Homo sapiens benzodiazapine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant 1, mRNA.	1417						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGCCTGCGGCTTGGGGGCTTC	0.653												
CIC	23152	broad.mit.edu	37	19	42791342	42791346	+	Frame_Shift_Del	DEL	CCCAG	CCCAG	-			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chr19:42791341_42791345CCCCAG>C	uc002otf.1	+	2	441_445	c.401_405CCCCAG>C	c.(400-405)cccccafs	p.P134fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	Homo sapiens capicua homolog (Drosophila) (CIC), mRNA.	134	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GCCTCCGGCCCCCCAGGAGAGCCCC	0.663			"""Mis, F, S"""		oligodendroglioma							
KDM5C	8242	broad.mit.edu	37	X	53228038	53228039	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CD-8532-01A-11D-2340-08	TCGA-CD-8532-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5a078dcc-ae7b-4b2d-a013-2183a7dc39a3	6fcf7d26-e5d1-4d82-8d07-8fa6927d3c03	g.chrX:53228037_53228038C>CA	uc004drz.3	-	15	2809_2810	c.2276_2277G>TG	c.(2275-2277)atgfs	p.M759fs	KDM5C_uc022bxe.1_Frame_Shift_Ins_p.M692fs|KDM5C_uc004dsa.3_Frame_Shift_Ins_p.M758fs	NM_004187	NP_004178	P41229	KDM5C_HUMAN	Homo sapiens lysine (K)-specific demethylase 5C (KDM5C), transcript variant 1, mRNA.	759					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						GCTTATGCAGCATGGCAGGAAG	0.579			"""N, F, S"""		clear cell renal carcinoma