Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
SLC45A1	50651	broad.mit.edu	37	1	8390936	8390936	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:8390936C>T	uc001apb.2	+	4	1383	c.1383C>T	c.(1381-1383)GAC>GAT	p.D461D	SLC45A1_uc001apc.2_Silent_p.D159D	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	461					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCATCCCGGACGCAGCCGGAG	0.607000												
PRAMEF12	390999	broad.mit.edu	37	1	12837182	12837182	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:12837182G>A	uc001aui.2	+	3	919	c.892G>A	c.(892-894)GTA>ATA	p.V298I		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	298										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGACAGTCGTAATGACCGA	0.542000												
ATP13A2	23400	broad.mit.edu	37	1	17323520	17323520	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:17323520C>T	uc001baa.2	-	12	1380	c.1190G>A	c.(1189-1191)CGC>CAC	p.R397H	ATP13A2_uc001bab.2_Missense_Mutation_p.R392H|ATP13A2_uc001bac.2_Missense_Mutation_p.R392H|ATP13A2_uc009vpa.1_Missense_Mutation_p.R110H|ATP13A2_uc001bad.1_Missense_Mutation_p.R110H	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	397	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CATACCTGTGCGGGTCACCAC	0.527000												
COL11A1	1301	broad.mit.edu	37	1	103488310	103488310	+	Silent	SNP	A	A	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:103488310A>G	uc001dul.2	-	8	1551	c.1233T>C	c.(1231-1233)ATT>ATC	p.I411I	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Silent_p.I423I|COL11A1_uc001dun.2_Silent_p.I372I|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	411	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TTGTTTCTGTAATATCAGTTT	0.338000												
MAN1A2	10905	broad.mit.edu	37	1	117963257	117963257	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:117963257C>A	uc001ehd.1	+	5	1562	c.841C>A	c.(841-843)CTA>ATA	p.L281I	MAN1A2_uc009whg.1_Missense_Mutation_p.L71I	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	281	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		AGCATATTACCTATCAGGAGA	0.363000												
HSD3B2	3284	broad.mit.edu	37	1	119964589	119964589	+	Silent	SNP	G	G	A	rs114527791	by1000genomes	TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:119964589G>A	uc001ehs.2	+	3	1238	c.465G>A	c.(463-465)CCG>CCA	p.P155P	HSD3B2_uc001eht.2_Silent_p.P155P|HSD3B2_uc001ehu.2_Intron	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	155			P -> L (in AH2; nonsalt-wasting form).		androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	CTCCATACCCGTACAGCAAAA	0.498000												
FMO5	2330	broad.mit.edu	37	1	146696558	146696558	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:146696558A>G	uc001epi.2	-	2	453	c.64T>C	c.(64-66)TGC>CGC	p.C22R	FMO5_uc001eph.3_Missense_Mutation_p.C22R|FMO5_uc001epj.2_Missense_Mutation_p.C22R|FMO5_uc001epk.3_Missense_Mutation_p.C22R	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	22						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					TCTTCTACGCAGCACTTGATG	0.502000												
ADAMTSL4	54507	broad.mit.edu	37	1	150532570	150532570	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:150532570C>T	uc001eux.2	+	19	3359	c.3123C>T	c.(3121-3123)CCC>CCT	p.P1041P	ADAMTSL4_uc009wlw.2_Silent_p.P1064P|ADAMTSL4_uc010pcg.1_Silent_p.P1002P|ADAMTSL4_uc009wlx.2_Silent_p.P204P	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	1041	PLAC.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CACATTGCCCCCTGGTGGTAC	0.617000											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
FLG	2312	broad.mit.edu	37	1	152277422	152277422	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:152277422T>A	uc001ezu.1	-	3	9976	c.9940A>T	c.(9940-9942)AGA>TGA	p.R3314*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3314	Filaggrin 20.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGAGTGTCTGGAGCTGTCT	0.562000									Ichthyosis			
FLG	2312	broad.mit.edu	37	1	152285533	152285533	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:152285533C>T	uc001ezu.1	-	3	1865	c.1829G>A	c.(1828-1830)GGG>GAG	p.G610E	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	610	Filaggrin 3.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGGGCCCCGATGATTG	0.572000									Ichthyosis			
DEDD	9191	broad.mit.edu	37	1	161092952	161092952	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:161092952G>A	uc001fxz.2	-	5	666	c.493C>T	c.(493-495)CGG>TGG	p.R165W	NIT1_uc001fxw.2_Intron|DEDD_uc009wty.2_Missense_Mutation_p.R165W|DEDD_uc001fya.2_Missense_Mutation_p.R165W|DEDD_uc001fyb.2_Missense_Mutation_p.R165W|DEDD_uc010pkb.1_Missense_Mutation_p.R122W|DEDD_uc001fyc.2_Missense_Mutation_p.R5W	NM_001039712	NP_001034801	O75618	DEDD_HUMAN	death effector domain-containing protein	165					apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding				0	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CGGGCTGGCCGCTTGCTACAC	0.547000												
SLC9A11	284525	broad.mit.edu	37	1	173556830	173556830	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:173556830C>T	uc001giz.2	-	5	920	c.497G>A	c.(496-498)CGT>CAT	p.R166H	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	166					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						ATTCACAGAACGAAGAGGATC	0.294000												
SRGAP2	23380	broad.mit.edu	37	1	206566910	206566910	+	Silent	SNP	C	C	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:206566910C>G	uc001hdy.2	+	4	783	c.450C>G	c.(448-450)GCC>GCG	p.A150A	SRGAP2_uc009xbt.2_Silent_p.A74A|SRGAP2_uc010prt.1_Silent_p.A74A|SRGAP2_uc001hdx.2_Silent_p.A150A|SRGAP2_uc010pru.1_Silent_p.A74A|SRGAP2_uc010prv.1_Silent_p.A74A	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	237					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					AGCGTCAAGCCAAGTACACGG	0.413000												
CENPF	1063	broad.mit.edu	37	1	214819047	214819047	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:214819047A>G	uc001hkm.2	+	13	6308	c.6134A>G	c.(6133-6135)CAG>CGG	p.Q2045R		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2141	Potential.|Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAGGACTCACAGGCACTGTCT	0.428000												
ZNF124	7678	broad.mit.edu	37	1	247320073	247320073	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:247320073T>A	uc001ick.2	-	4	990	c.851A>T	c.(850-852)CAT>CTT	p.H284L	ZNF124_uc001ici.2_Intron|ZNF124_uc001icj.1_Missense_Mutation_p.H222L	NM_003431	NP_003422	Q15973	ZN124_HUMAN	zinc finger protein 124	284	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			CTGTGCAATATGAGTTTTCTC	0.443000												
OR2T1	26696	broad.mit.edu	37	1	248569964	248569964	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr1:248569964G>T	uc010pzm.1	+	1	669	c.669G>T	c.(667-669)GAG>GAT	p.E223D		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	223	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTCCCGGGAGATTAACCACT	0.507000												
OSBPL5	114879	broad.mit.edu	37	11	3115056	3115056	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr11:3115056C>T	uc001lxk.2	-	16	1887	c.1729G>A	c.(1729-1731)GGG>AGG	p.G577R	OSBPL5_uc010qxq.1_Missense_Mutation_p.G488R|OSBPL5_uc009ydw.2_Missense_Mutation_p.G509R|OSBPL5_uc001lxl.2_Missense_Mutation_p.G509R|OSBPL5_uc009ydx.2_Missense_Mutation_p.G601R|OSBPL5_uc001lxj.2_Missense_Mutation_p.G31R	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	577					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GTGCTACCCCCGAAGAAGGGC	0.627000												
OR4A47	403253	broad.mit.edu	37	11	48510483	48510483	+	Missense_Mutation	SNP	G	G	A	rs142333570	byFrequency	TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr11:48510483G>A	uc010rhx.1	+	1	139	c.139G>A	c.(139-141)GTA>ATA	p.V47I		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGTAGTGACCGTAACTGTCAG	0.418000												
OR5M3	219482	broad.mit.edu	37	11	56237295	56237295	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr11:56237295G>A	uc010rjk.1	-	1	679	c.679C>T	c.(679-681)CGC>TGC	p.R227C		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TCTGCTGAGCGCATTCGCAGA	0.418000												
DSCAML1	57453	broad.mit.edu	37	11	117651260	117651260	+	Silent	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr11:117651260G>A	uc001prh.1	-	2	494	c.492C>T	c.(490-492)ACC>ACT	p.T164T	DSCAML1_uc001pri.1_5'UTR	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	104	Extracellular (Potential).|Ig-like C2-type 1.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CGTTCTCCGCGGTGCAGAAGT	0.622000												
CACNA1C	775	broad.mit.edu	37	12	2788847	2788847	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr12:2788847C>T	uc009zdu.1	+	44	5786	c.5473C>T	c.(5473-5475)CGC>TGC	p.R1825C	CACNA1C_uc009zdv.1_Missense_Mutation_p.R1774C|CACNA1C_uc001qkb.2_Missense_Mutation_p.R1777C|CACNA1C_uc001qkc.2_Missense_Mutation_p.R1796C|CACNA1C_uc001qke.2_Missense_Mutation_p.R1766C|CACNA1C_uc001qkf.2_Missense_Mutation_p.R1785C|CACNA1C_uc001qjz.2_Missense_Mutation_p.R1777C|CACNA1C_uc001qkd.2_Missense_Mutation_p.R1796C|CACNA1C_uc001qkg.2_Missense_Mutation_p.R1783C|CACNA1C_uc009zdw.1_Missense_Mutation_p.R1818C|CACNA1C_uc001qkh.2_Missense_Mutation_p.R1785C|CACNA1C_uc001qkl.2_Missense_Mutation_p.R1825C|CACNA1C_uc001qkn.2_Missense_Mutation_p.R1777C|CACNA1C_uc001qko.2_Missense_Mutation_p.R1797C|CACNA1C_uc001qkp.2_Missense_Mutation_p.R1777C|CACNA1C_uc001qkr.2_Missense_Mutation_p.R1794C|CACNA1C_uc001qku.2_Missense_Mutation_p.R1777C|CACNA1C_uc001qkq.2_Missense_Mutation_p.R1805C|CACNA1C_uc001qks.2_Missense_Mutation_p.R1777C|CACNA1C_uc001qkt.2_Missense_Mutation_p.R1796C|CACNA1C_uc001qki.1_Missense_Mutation_p.R1513C|CACNA1C_uc001qkj.1_Missense_Mutation_p.R1513C|CACNA1C_uc001qkk.1_Missense_Mutation_p.R1513C|CACNA1C_uc001qkm.1_Missense_Mutation_p.R1502C|CACNA1C_uc010sea.1_Missense_Mutation_p.R468C|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.R95C	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1825	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CGCCCTGGGTCGCCTCCCTCG	0.677000												
ACRBP	84519	broad.mit.edu	37	12	6748124	6748124	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr12:6748124C>T	uc001qpu.1	-	9	1553	c.1505G>A	c.(1504-1506)CGG>CAG	p.R502Q	LPAR5_uc001qps.2_5'Flank|LPAR5_uc010sff.1_5'UTR|ACRBP_uc001qpt.1_5'Flank|ACRBP_uc010sfg.1_Missense_Mutation_p.R469Q	NM_032489	NP_115878	Q8NEB7	ACRBP_HUMAN	proacrosin binding protein sp32 precursor	502						acrosomal vesicle|extracellular region				central_nervous_system(1)	1						GCTCACCTTCCGATTGCGGTT	0.532000												
CDCA3	83461	broad.mit.edu	37	12	6958779	6958779	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr12:6958779C>G	uc001qrg.2	-	4	622	c.494G>C	c.(493-495)AGC>ACC	p.S165T	CDCA3_uc001qre.2_Missense_Mutation_p.S165T|uc001qrf.1_5'Flank|USP5_uc001qri.3_5'Flank|USP5_uc001qrh.3_5'Flank	NM_031299	NP_112589	Q99618	CDCA3_HUMAN	cell division cycle associated 3	165					cell division|mitosis	cytosol					0						GGAGCTCTGGCTGGCCACAGG	0.512000												
ABCC9	10060	broad.mit.edu	37	12	22001093	22001093	+	Missense_Mutation	SNP	C	C	T	rs143685061		TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr12:22001093C>T	uc001rfi.1	-	23	2877	c.2857G>A	c.(2857-2859)GAA>AAA	p.E953K	ABCC9_uc001rfh.2_Missense_Mutation_p.E953K|ABCC9_uc001rfj.1_Missense_Mutation_p.E917K	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	953	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CCTTCGTCTTCGTCCTCCATC	0.418000												
C12orf40	283461	broad.mit.edu	37	12	40114807	40114807	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr12:40114807C>T	uc001rmc.2	+	13	1880	c.1713C>T	c.(1711-1713)TGC>TGT	p.C571C	C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	571								p.C571G(1)		ovary(6)	6						AGTTGCAGTGCAATTCAGCCC	0.388000												
CNTN1	1272	broad.mit.edu	37	12	41387064	41387064	+	Silent	SNP	C	C	T	rs147943881		TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr12:41387064C>T	uc001rmm.1	+	17	2219	c.2106C>T	c.(2104-2106)GAC>GAT	p.D702D	CNTN1_uc001rmn.1_Silent_p.D691D	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	702					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTAAAACAGACGGTGCTGGTA	0.368000												
TMTC2	160335	broad.mit.edu	37	12	83251144	83251144	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr12:83251144T>G	uc001szt.2	+	2	871	c.439T>G	c.(439-441)TTC>GTC	p.F147V	TMTC2_uc001szr.1_Missense_Mutation_p.F147V|TMTC2_uc001szs.1_Missense_Mutation_p.F147V|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	147	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						GGCCAGTCTCTTCTTTCTCCT	0.552000												
DNAH10	196385	broad.mit.edu	37	12	124416550	124416550	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr12:124416550C>T	uc001uft.3	+	75	12862	c.12837C>T	c.(12835-12837)ATC>ATT	p.I4279I	DNAH10_uc001ufu.3_Silent_p.I192I	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	4279					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTCTTTTTATCGGGCATATCC	0.478000												
NUPL1	9818	broad.mit.edu	37	13	25883397	25883397	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr13:25883397C>T	uc001uqi.2	+	3	509	c.263C>T	c.(262-264)ACT>ATT	p.T88I	NUPL1_uc001uqg.1_Missense_Mutation_p.T88I|NUPL1_uc001uqj.2_Intron	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	88	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		ATAGCAACAACTATAACTACA	0.318000												
TUBGCP3	10426	broad.mit.edu	37	13	113212621	113212621	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr13:113212621C>T	uc001vse.1	-	5	624	c.437G>A	c.(436-438)CGG>CAG	p.R146Q	TUBGCP3_uc010tjq.1_Missense_Mutation_p.R136Q|TUBGCP3_uc001vsf.2_Missense_Mutation_p.R146Q|TUBGCP3_uc001vsg.1_Missense_Mutation_p.R146Q	NM_006322	NP_006313	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	146					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					CTGGGCACTCCGATCTTGGTA	0.602000												
MAPK1IP1L	93487	broad.mit.edu	37	14	55529793	55529793	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr14:55529793G>A	uc001xbq.1	+	3	640	c.476G>A	c.(475-477)GGG>GAG	p.G159E		NM_144578	NP_653179	Q8NDC0	MISSL_HUMAN	MAPK-interacting and spindle-stabilizing	159	Pro-rich.										0						GGAATGGGAGGGCAGTATCCT	0.597000												
PLD4	122618	broad.mit.edu	37	14	105398406	105398406	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr14:105398406C>T	uc001ypu.1	+	9	1257	c.1116C>T	c.(1114-1116)CGC>CGT	p.R372R	PLD4_uc010tyl.1_Silent_p.R379R	NM_138790	NP_620145	Q96BZ4	PLD4_HUMAN	phospholipase D4	372					lipid catabolic process	integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity			central_nervous_system(1)|skin(1)	2		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.00067)|OV - Ovarian serous cystadenocarcinoma(23;0.00976)|Epithelial(46;0.0201)|GBM - Glioblastoma multiforme(11;0.116)		Choline(DB00122)	AGGGCGTGCGCGTGCGCCTGC	0.711000												
ATP10A	57194	broad.mit.edu	37	15	25928567	25928567	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr15:25928567G>T	uc010ayu.2	-	17	3464	c.3358C>A	c.(3358-3360)CAG>AAG	p.Q1120K		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1120	Helical; (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		AGATACCACTGGTCAATCATG	0.498000												
CSPG4	1464	broad.mit.edu	37	15	75968312	75968312	+	Missense_Mutation	SNP	C	C	T	rs149670354		TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr15:75968312C>T	uc002baw.2	-	10	6641	c.6548G>A	c.(6547-6549)CGG>CAG	p.R2183Q		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	2183	Extracellular (Potential).|Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TGCTTCCGTCCGGGCGGCCTC	0.697000												
HBQ1	3049	broad.mit.edu	37	16	231013	231013	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr16:231013G>A	uc002cfz.2	+	3	486	c.335G>A	c.(334-336)CGG>CAG	p.R112Q		NM_005331	NP_005322	P09105	HBAT_HUMAN	theta 1 globin	112						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				ACCCTCGCCCGGCACTACCCC	0.701000												
ACSM3	6296	broad.mit.edu	37	16	20793081	20793081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr16:20793081C>T	uc002dhr.2	+	7	1178	c.991C>T	c.(991-993)CGA>TGA	p.R331*	ACSM3_uc002dhq.2_Nonsense_Mutation_p.R331*|ACSM3_uc010vba.1_Nonsense_Mutation_p.R360*|ERI2_uc002dhs.2_Intron	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	331					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						AACTGTATACCGAATGCTTGT	0.378000												
MYST1	84148	broad.mit.edu	37	16	31131779	31131779	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr16:31131779C>T	uc002eay.2	+	3	424	c.406C>T	c.(406-408)CGC>TGC	p.R136C	MYST1_uc002eax.2_Missense_Mutation_p.R136C	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	136					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						GCAGCCTGAGCGCAAGATCAC	0.567000												
ABCC11	85320	broad.mit.edu	37	16	48247385	48247385	+	Missense_Mutation	SNP	G	G	A	rs148839428		TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr16:48247385G>A	uc002eff.1	-	9	1675	c.1325C>T	c.(1324-1326)ACG>ATG	p.T442M	ABCC11_uc002efg.1_Missense_Mutation_p.T442M|ABCC11_uc002efh.1_Missense_Mutation_p.T442M|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	442	Cytoplasmic (Potential).|ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CTTGGAATTCGTGAGACCTTT	0.552000									Cerumen_Type			
NEURL4	84461	broad.mit.edu	37	17	7231011	7231011	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr17:7231011C>T	uc002gga.1	-	2	482	c.475G>A	c.(475-477)GTG>ATG	p.V159M	NEURL4_uc002ggb.1_Missense_Mutation_p.V159M|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	159	NHR 1.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						TCCACGCCCACGCGGTCCCCT	0.657000												
TP53	7157	broad.mit.edu	37	17	7578479	7578479	+	Missense_Mutation	SNP	G	G	T	rs28934874		TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr17:7578479G>T	uc002gim.2	-	5	645	c.451C>A	c.(451-453)CCC>ACC	p.P151T	TP53_uc002gig.1_Missense_Mutation_p.P151T|TP53_uc002gih.2_Missense_Mutation_p.P151T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.P19T|TP53_uc010cng.1_Missense_Mutation_p.P19T|TP53_uc002gii.1_Missense_Mutation_p.P19T|TP53_uc010cnh.1_Missense_Mutation_p.P151T|TP53_uc010cni.1_Missense_Mutation_p.P151T|TP53_uc002gij.2_Missense_Mutation_p.P151T|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.P58T|TP53_uc002gio.2_Missense_Mutation_p.P19T|TP53_uc010vug.1_Missense_Mutation_p.P112T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	151	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		P -> R (in sporadic cancers; somatic mutation).|P -> A (in sporadic cancers; somatic mutation).|P -> L (in sporadic cancers; somatic mutation).|P -> H (in sporadic cancers; somatic mutation).|P -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P151S(61)|p.P151H(25)|p.P151T(13)|p.P151P(12)|p.P151A(10)|p.P152fs*18(9)|p.0?(7)|p.P151fs*30(7)|p.P151L(6)|p.P151R(6)|p.T150fs*16(3)|p.P151_V173del23(1)|p.P152_P153del(1)|p.P152fs*28(1)|p.P151del(1)|p.D148_T155delDSTPPPGT(1)|p.T150_P153delTPPP(1)|p.P58A(1)|p.D148fs*23(1)|p.S149fs*72(1)|p.S149fs*17(1)|p.Q144_G154del11(1)|p.P19A(1)|p.P152fs*14(1)|p.T150_P151delTP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGGCGGGGGTGTGGAATCA	0.612000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
ULK2	9706	broad.mit.edu	37	17	19689396	19689396	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr17:19689396G>A	uc002gwm.3	-	21	2614	c.2105C>T	c.(2104-2106)CCG>CTG	p.P702L	ULK2_uc002gwn.2_Missense_Mutation_p.P702L	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	702					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GGCTCCTGCCGGAGCTACAAC	0.498000												
TAOK1	57551	broad.mit.edu	37	17	27844528	27844528	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr17:27844528C>T	uc002hdz.1	+	16	1956	c.1762C>T	c.(1762-1764)CAG>TAG	p.Q588*	TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Nonsense_Mutation_p.Q588*	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	588	Potential.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			GCTTTCAAAGCAGAAGGAGAA	0.388000												
ADAP2	55803	broad.mit.edu	37	17	29281526	29281526	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr17:29281526G>T	uc002hfx.2	+	9	1114	c.835G>T	c.(835-837)GCC>TCC	p.A279S	ADAP2_uc010csk.2_Missense_Mutation_p.A285S|ADAP2_uc002hfy.2_Missense_Mutation_p.A278S|ADAP2_uc010csl.2_RNA	NM_018404	NP_060874	Q9NPF8	ADAP2_HUMAN	centaurin-alpha 2 protein	279	PH 2.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		ovary(1)	1						AAGGTGGTTCGCCCTGGATTG	0.537000												
MED13	9969	broad.mit.edu	37	17	60061595	60061595	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr17:60061595C>G	uc002izo.2	-	15	2902	c.2825G>C	c.(2824-2826)AGT>ACT	p.S942T		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	942					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						AACAGTCCAACTCTGACGGTA	0.403000												
SYNGR2	9144	broad.mit.edu	37	17	76168001	76168001	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr17:76168001C>T	uc002juu.1	+	4	686	c.659C>T	c.(658-660)CCG>CTG	p.P220L	SYNGR2_uc002jut.2_Missense_Mutation_p.R250C|SYNGR2_uc002juv.1_3'UTR|SYNGR2_uc010dhi.1_RNA	NM_004710	NP_004701	O43760	SNG2_HUMAN	synaptogyrin 2	220						integral to plasma membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			GGCTACCAGCCGCCCCCTGTG	0.647000												
DSEL	92126	broad.mit.edu	37	18	65181679	65181679	+	Missense_Mutation	SNP	A	A	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr18:65181679A>G	uc002lke.1	-	2	1421	c.197T>C	c.(196-198)CTG>CCG	p.L66P		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	56						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				ACTTTTCTTCAGCTTTTGGTT	0.378000												
NFATC1	4772	broad.mit.edu	37	18	77171139	77171139	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr18:77171139C>T	uc010xfg.1	+	2	1317	c.864C>T	c.(862-864)CAC>CAT	p.H288H	NFATC1_uc002lnc.1_Silent_p.H288H|NFATC1_uc010xff.1_Silent_p.H288H|NFATC1_uc002lnd.2_Silent_p.H288H|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Silent_p.H288H|NFATC1_uc010xfi.1_Silent_p.H275H|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Silent_p.H275H|NFATC1_uc002lng.2_Silent_p.H275H|NFATC1_uc010xfk.1_Silent_p.H275H	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	288	3 X SP repeats.|3.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGTCCCCGCACGGCTCCCCGC	0.692000												
ELANE	1991	broad.mit.edu	37	19	853309	853309	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr19:853309G>A	uc002lqb.2	+	3	310	c.272G>A	c.(271-273)CGG>CAG	p.R91Q		NM_001972	NP_001963	P08246	ELNE_HUMAN	neutrophil elastase preproprotein	91	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			pancreas(1)	1					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	AACCTCTCGCGGCGGGAGCCC	0.672000									Kostmann_syndrome			
HMHA1	23526	broad.mit.edu	37	19	1079752	1079752	+	Silent	SNP	G	G	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr19:1079752G>T	uc002lqz.1	+	12	1656	c.1425G>T	c.(1423-1425)ACG>ACT	p.T475T	HMHA1_uc010xgd.1_Silent_p.T491T|HMHA1_uc010xge.1_Silent_p.T315T|HMHA1_uc002lra.1_Silent_p.T315T|HMHA1_uc002lrb.1_Silent_p.T358T|HMHA1_uc002lrc.1_Silent_p.T110T	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	475	Potential.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCGAAGACGCAGAAGCAGG	0.682000												
CLEC17A	388512	broad.mit.edu	37	19	14705596	14705596	+	Silent	SNP	T	T	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr19:14705596T>C	uc010dzn.1	+	7	464	c.387T>C	c.(385-387)TGT>TGC	p.C129C	CLEC17A_uc002mzh.1_Silent_p.C112C|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Silent_p.C129C|CLEC17A_uc010dzo.1_Silent_p.C129C			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	129	Cytoplasmic (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						CTGTCACCTGTCCACCTCCTC	0.488000												
ZNF568	374900	broad.mit.edu	37	19	37488168	37488168	+	Silent	SNP	T	T	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr19:37488168T>C	uc010efg.2	+	10	2090	c.1533T>C	c.(1531-1533)CAT>CAC	p.H511H	ZNF568_uc010xtn.1_Silent_p.H449H|uc010efi.2_Silent_p.H329H|uc010efj.2_Silent_p.H329H			Q3ZCX4	ZN568_HUMAN	SubName: Full=cDNA FLJ57578, moderately similar to Mus musculus zinc finger protein 568 (Zfp568), mRNA;	548	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTATTCGACATCAGAGTGTCC	0.448000												
PRX	57716	broad.mit.edu	37	19	40900427	40900427	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr19:40900427C>T	uc002onr.2	-	7	4101	c.3832G>A	c.(3832-3834)GAC>AAC	p.D1278N	PRX_uc002onq.2_Missense_Mutation_p.D1139N|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1278					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGCTCCACGTCGGGCAGTGAG	0.687000												
CYP2A13	1553	broad.mit.edu	37	19	41600977	41600977	+	Missense_Mutation	SNP	G	G	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr19:41600977G>C	uc002opt.2	+	8	1284	c.1275G>C	c.(1273-1275)AAG>AAC	p.K425N		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	425					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	AGTTTAAGAAGAGTGATGCTT	0.577000												
SHANK1	50944	broad.mit.edu	37	19	51171798	51171798	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr19:51171798G>A	uc002psx.1	-	22	3438	c.3419C>T	c.(3418-3420)CCG>CTG	p.P1140L	SHANK1_uc002psw.1_Missense_Mutation_p.P524L	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1140					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ggcgggcggcggctgcgggga	0.443000												
LILRA5	353514	broad.mit.edu	37	19	54823401	54823401	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr19:54823401T>C	uc002qfe.2	-	4	262	c.142A>G	c.(142-144)ACC>GCC	p.T48A	LILRA5_uc002qff.2_Missense_Mutation_p.T36A|LILRA5_uc010yev.1_Missense_Mutation_p.T48A|LILRA5_uc010yew.1_Missense_Mutation_p.T36A|LILRA5_uc002qfh.1_Missense_Mutation_p.T36A|LILRA5_uc002qfg.1_Missense_Mutation_p.T48A	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	48	Extracellular (Potential).				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCCCAGAGGGTGGCTTTGGAG	0.617000												
TPO	7173	broad.mit.edu	37	2	1507810	1507810	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr2:1507810C>T	uc002qww.2	+	14	2568	c.2477C>T	c.(2476-2478)GCG>GTG	p.A826V	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.A769V|TPO_uc002qwr.2_Missense_Mutation_p.A826V|TPO_uc002qwx.2_Missense_Mutation_p.A769V|TPO_uc010yio.1_Missense_Mutation_p.A653V|TPO_uc010yip.1_Intron|TPO_uc002qwy.1_Intron|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	826	Extracellular (Potential).|EGF-like; calcium-binding (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGTCTCTGCGCGGACCCCTAC	0.572000												
C2orf44	80304	broad.mit.edu	37	2	24261172	24261172	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr2:24261172A>C	uc002rep.2	-	2	1324	c.1193T>G	c.(1192-1194)CTA>CGA	p.L398R	C2orf44_uc010eya.2_Missense_Mutation_p.L398R	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	398							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AATTAGTAATAGTTGGTCTGT	0.353000												
NCOA1	8648	broad.mit.edu	37	2	24964833	24964833	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr2:24964833G>A	uc002rfk.2	+	17	3742	c.3484G>A	c.(3484-3486)GGT>AGT	p.G1162S	NCOA1_uc010eye.2_Missense_Mutation_p.G1162S|NCOA1_uc002rfi.2_Missense_Mutation_p.G1011S|NCOA1_uc002rfj.2_Missense_Mutation_p.G1162S|NCOA1_uc002rfl.2_Missense_Mutation_p.G1162S|NCOA1_uc010eyf.2_Missense_Mutation_p.G55S	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1162									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTCCTCAGGGTGCTCCACA	0.522000			T	PAX3	alveolar rhadomyosarcoma							
C2orf39	92749	broad.mit.edu	37	2	26677608	26677608	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr2:26677608C>T	uc002rhg.2	+	15	2087	c.2013C>T	c.(2011-2013)TCC>TCT	p.S671S		NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	671											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGATCCCTTCCTCCAAGCAGA	0.592000												
TTN	7273	broad.mit.edu	37	2	179417913	179417913	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr2:179417913T>C	uc010zfg.1	-	284	82234	c.82010A>G	c.(82009-82011)AAT>AGT	p.N27337S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.N21032S|TTN_uc010zfi.1_Missense_Mutation_p.N20965S|TTN_uc010zfj.1_Missense_Mutation_p.N20840S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28264							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTGTATCATTGCGAGTAAC	0.408000												
CRYGD	1421	broad.mit.edu	37	2	208988895	208988895	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr2:208988895C>T	uc002vcn.3	-	2	309	c.193G>A	c.(193-195)GAC>AAC	p.D65N		NM_006891	NP_008822	P07320	CRGD_HUMAN	crystallin, gamma D	65	Beta/gamma crystallin 'Greek key' 2.				cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		TGCTGGTGGTCGGCATAGTCG	0.662000												
SCG2	7857	broad.mit.edu	37	2	224463718	224463718	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr2:224463718C>T	uc002vnm.2	-	2	416	c.283G>A	c.(283-285)GAT>AAT	p.D95N		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	95					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGGCTTTCATCGCCATTTTCT	0.463000												
JAG1	182	broad.mit.edu	37	20	10639259	10639259	+	Missense_Mutation	SNP	C	C	T	rs121918351		TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr20:10639259C>T	uc002wnw.2	-	4	1067	c.551G>A	c.(550-552)CGC>CAC	p.R184H		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	184	Extracellular (Potential).		R -> C (in ALGS1).|R -> H (in ALGS1).|R -> G (in ALGS1).|R -> L (in ALGS1).		angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						ACAGGTCACGCGGATCTGATA	0.522000									Alagille_Syndrome			
SSTR4	6754	broad.mit.edu	37	20	23016919	23016919	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr20:23016919G>A	uc002wsr.2	+	1	863	c.799G>A	c.(799-801)GTC>ATC	p.V267I		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	267	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GGTCGTGGTCGTCTTTGTGCT	0.607000												
SEMG2	6407	broad.mit.edu	37	20	43850987	43850987	+	Silent	SNP	C	C	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr20:43850987C>A	uc010ggz.2	+	2	771	c.714C>A	c.(712-714)CTC>CTA	p.L238L	SEMG2_uc002xnk.2_Silent_p.L238L|SEMG2_uc002xnl.2_Silent_p.L238L	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	238	2-2.|Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				AAACTTCACTCCATCCTGCAC	0.378000												
ARFGEF2	10564	broad.mit.edu	37	20	47639687	47639687	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr20:47639687A>C	uc002xtx.3	+	35	4876	c.4724A>C	c.(4723-4725)AAG>ACG	p.K1575T	ARFGEF2_uc010zyf.1_Missense_Mutation_p.K868T	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1575					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			ACGAGCAAAAAGGAGGATGCA	0.478000												
CBLN4	140689	broad.mit.edu	37	20	54579014	54579014	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr20:54579014C>T	uc002xxa.2	-	1	999	c.214G>A	c.(214-216)GCC>ACC	p.A72T		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	72	C1q.					cell junction|extracellular region|synapse		p.A72T(1)		ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			GCCGAGAAGGCGACCTTGGAG	0.637000												
ZNF831	128611	broad.mit.edu	37	20	57766931	57766931	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr20:57766931C>T	uc002yan.2	+	1	857	c.857C>T	c.(856-858)GCG>GTG	p.A286V		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	286						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCCCCCATGGCGTCACCTGGG	0.662000												
GTPBP5	26164	broad.mit.edu	37	20	60768650	60768650	+	Silent	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr20:60768650G>A	uc002yce.3	+	2	212	c.174G>A	c.(172-174)CCG>CCA	p.P58P	GTPBP5_uc011aab.1_Intron|GTPBP5_uc011aac.1_Intron|GTPBP5_uc011aad.1_5'UTR|GTPBP5_uc011aae.1_Intron|GTPBP5_uc011aaf.1_Silent_p.P58P|GTPBP5_uc011aag.1_Silent_p.P58P	NM_015666	NP_056481	Q9H4K7	GTPB5_HUMAN	GTP binding protein 5	58	Localized in the mitocondria.|Not localized in the mitocondria.				ribosome biogenesis	mitochondrion	GTP binding|GTPase activity|magnesium ion binding				0	Breast(26;3.52e-09)		BRCA - Breast invasive adenocarcinoma(19;2.5e-08)			AGGAACTCCCGGGGAAGAAGC	0.627000												
TIAM1	7074	broad.mit.edu	37	21	32493107	32493107	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr21:32493107C>T	uc002yow.1	-	29	4827	c.4355G>A	c.(4354-4356)CGA>CAA	p.R1452Q	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Missense_Mutation_p.R1392Q	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1452					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						AAACCTGTTTCGAGCCAGCCG	0.552000												
C21orf63	59271	broad.mit.edu	37	21	33867373	33867373	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr21:33867373G>A	uc002ypr.1	+	5	1081	c.671G>A	c.(670-672)CGA>CAA	p.R224Q	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.R224Q|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.R129Q|C21orf63_uc011adq.1_5'UTR	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	224	SUEL-type lectin 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						GTCCTATCCCGAAGGTGCTAT	0.488000												
SEC14L2	23541	broad.mit.edu	37	22	30812329	30812329	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr22:30812329C>T	uc003ahr.2	+	11	1191	c.1018C>T	c.(1018-1020)CAG>TAG	p.Q340*	SEC14L2_uc003ahq.2_Nonsense_Mutation_p.Q340*|SEC14L2_uc011akx.1_Nonsense_Mutation_p.Q286*|SEC14L2_uc003ahs.2_Nonsense_Mutation_p.Q266*|SEC14L2_uc011aky.1_Nonsense_Mutation_p.Q257*|SEC14L2_uc003aht.2_RNA|SEC14L2_uc003ahu.3_Intron|SEC14L2_uc010gvv.2_RNA|SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Nonsense_Mutation_p.Q33*|MTP18_uc003ahv.1_Nonsense_Mutation_p.Q164*|MTP18_uc010gvy.1_Intron	NM_012429	NP_036561	O76054	S14L2_HUMAN	SEC14-like 2 isoform 1	340	GOLD.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	phospholipid binding|transporter activity|vitamin E binding				0					Vitamin E(DB00163)	GCTGCCCAACCAGAGGTACAA	0.547000												
SEC14L4	284904	broad.mit.edu	37	22	30891385	30891385	+	Silent	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr22:30891385G>A	uc003aid.2	-	5	379	c.279C>T	c.(277-279)TAC>TAT	p.Y93Y	SEC14L4_uc011akz.1_Silent_p.Y93Y|SEC14L4_uc003aie.2_Silent_p.Y78Y|SEC14L4_uc003aif.2_Silent_p.Y39Y	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	93	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	GGCAGCCTTCGTAGTCGTAGC	0.562000												
CNTN6	27255	broad.mit.edu	37	3	1414148	1414148	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr3:1414148G>T	uc003boz.2	+	13	1925	c.1658G>T	c.(1657-1659)AGG>ATG	p.R553M	CNTN6_uc011asj.1_Missense_Mutation_p.R481M|CNTN6_uc003bpa.2_Missense_Mutation_p.R553M	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	553	Ig-like C2-type 6.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CATTTTGAAAGGATTGGAGGA	0.358000												
CPNE9	151835	broad.mit.edu	37	3	9756630	9756630	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr3:9756630G>A	uc003bsd.2	+	10	854	c.683G>A	c.(682-684)CGG>CAG	p.R228Q		NM_153635	NP_705899	Q8IYJ1	CPNE9_HUMAN	copine-like protein	228	C2 2.									ovary(2)	2	Medulloblastoma(99;0.227)					GACTGGGACCGGGATGGAAGG	0.453000												
BSN	8927	broad.mit.edu	37	3	49680203	49680203	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr3:49680203C>A	uc003cxe.3	+	3	1250	c.1136C>A	c.(1135-1137)CCC>CAC	p.P379H		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	379					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CAGCCTGCCCCCAGCAAGGGG	0.652000												
PCOLCE2	26577	broad.mit.edu	37	3	142567080	142567080	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr3:142567080C>T	uc003evd.2	-	3	623	c.427G>A	c.(427-429)GCT>ACT	p.A143T		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	143	CUB 1.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						GGTTCAGCAGCGGAGAACATG	0.458000												
MME	4311	broad.mit.edu	37	3	154832866	154832866	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr3:154832866C>T	uc010hvr.1	+	4	491	c.280C>T	c.(280-282)CGT>TGT	p.R94C	MME_uc003fab.1_Missense_Mutation_p.R94C|MME_uc003fac.1_Missense_Mutation_p.R94C|MME_uc003fad.1_Missense_Mutation_p.R94C|MME_uc003fae.1_Missense_Mutation_p.R94C	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	94	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CTGGTTGAAACGTAATGTCAT	0.448000												
FGF12	2257	broad.mit.edu	37	3	192053209	192053209	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr3:192053209G>A	uc003fsx.2	-	3	1181	c.355C>T	c.(355-357)CAA>TAA	p.Q119*	FGF12_uc003fsy.2_Nonsense_Mutation_p.Q57*	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	119					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTCACTCCTTGGATGGCCACT	0.458000												
KIAA1530	57654	broad.mit.edu	37	4	1345537	1345537	+	Missense_Mutation	SNP	C	C	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr4:1345537C>G	uc003gde.3	+	4	911	c.464C>G	c.(463-465)GCA>GGA	p.A155G		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	155											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			CGGAGTCTGGCAGAAAGGAAG	0.373000											OREG0016033	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
FRAS1	80144	broad.mit.edu	37	4	79396677	79396677	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr4:79396677C>T	uc003hlb.2	+	54	8208	c.7768C>T	c.(7768-7770)CGC>TGC	p.R2590C		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2589	Calx-beta 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CGTCCTGTGTCGCACCGAGCA	0.577000												
LEF1	51176	broad.mit.edu	37	4	108991888	108991888	+	Silent	SNP	A	A	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr4:108991888A>G	uc003hyt.1	-	9	1702	c.1047T>C	c.(1045-1047)TAT>TAC	p.Y349Y	LEF1_uc011cfj.1_Silent_p.Y206Y|LEF1_uc011cfk.1_Silent_p.Y253Y|LEF1_uc003hyu.1_Silent_p.Y321Y|LEF1_uc003hyv.1_Silent_p.Y321Y|LEF1_uc010imb.1_RNA|LEF1_uc003hys.1_RNA|LEF1_uc010ima.1_Silent_p.Y37Y|LEF1_uc003hyw.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	349	HMG box.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GTGCTAATTCATAATATTTAG	0.418000												
HAND2	9464	broad.mit.edu	37	4	174450016	174450016	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr4:174450016C>T	uc003ith.1	-	1	1363	c.425G>A	c.(424-426)CGC>CAC	p.R142H	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Silent_p.A107A|HAND2_uc010ire.1_Missense_Mutation_p.R142H	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	142	Helix-loop-helix motif.				adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		GGTGGCCAGGCGCAGGGTCTT	0.612000												
FAT1	2195	broad.mit.edu	37	4	187557880	187557880	+	Silent	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr4:187557880G>A	uc003izf.2	-	5	4019	c.3831C>T	c.(3829-3831)ACC>ACT	p.T1277T		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1277	Extracellular (Potential).|Cadherin 11.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						CATCCTTGTCGGTGGCTATGA	0.493000										HNSCC(5;0.00058)		
UGT3A1	133688	broad.mit.edu	37	5	35965682	35965682	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr5:35965682T>C	uc003jjv.1	-	4	806	c.649A>G	c.(649-651)ATG>GTG	p.M217V	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.M217V|UGT3A1_uc011cor.1_Missense_Mutation_p.M183V|UGT3A1_uc003jjy.1_Missense_Mutation_p.M163V	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	217	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTAGACTGCATGTCCCATTGG	0.448000												
C5orf42	65250	broad.mit.edu	37	5	37170433	37170433	+	Silent	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr5:37170433G>A	uc011cpa.1	-	33	6403	c.6172C>T	c.(6172-6174)CTG>TTG	p.L2058L	C5orf42_uc011coy.1_Silent_p.L558L|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Silent_p.L1133L|C5orf42_uc003jkr.1_Silent_p.L91L	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2058										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ATCTGTTGCAGCTTGAATAAA	0.338000												
CHSY3	337876	broad.mit.edu	37	5	129241195	129241195	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr5:129241195G>A	uc003kvd.2	+	1	673	c.673G>A	c.(673-675)GCG>ACG	p.A225T		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	225	Lumenal (Potential).|Pro-rich.					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GCCTGTCATCGCGCTACCGGG	0.612000												
SLC36A2	153201	broad.mit.edu	37	5	150696616	150696616	+	Missense_Mutation	SNP	A	A	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr5:150696616A>C	uc003lty.2	-	10	1344	c.1214T>G	c.(1213-1215)CTG>CGG	p.L405R	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_Missense_Mutation_p.L207R	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	405	Helical; (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGAGATGACCAGGTCCAGGCG	0.607000												
EEF1E1	9521	broad.mit.edu	37	6	8097522	8097522	+	Missense_Mutation	SNP	T	T	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr6:8097522T>C	uc003mxz.2	-	2	340	c.266A>G	c.(265-267)AAT>AGT	p.N89S	EEF1E1_uc011dic.1_Missense_Mutation_p.N89S	NM_004280	NP_004271	O43324	MCA3_HUMAN	eukaryotic translation elongation factor 1	89	GST C-terminal.				negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of DNA damage response, signal transduction by p53 class mediator|tRNA aminoacylation for protein translation	cytosol|nucleus					0	Ovarian(93;0.0398)					GTGGATGTCATTTTTACTGGA	0.403000												
HIVEP1	3096	broad.mit.edu	37	6	12125570	12125570	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr6:12125570G>A	uc003nac.2	+	4	5721	c.5542G>A	c.(5542-5544)GTT>ATT	p.V1848I	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1848					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TAAATTTGTCGTTATAGAACC	0.338000												
CRISP3	10321	broad.mit.edu	37	6	49704128	49704128	+	Silent	SNP	G	G	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr6:49704128G>C	uc003ozs.2	-	3	180	c.165C>G	c.(163-165)CCC>CCG	p.P55P		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	55					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTCTGGCAGGGGGAGATACTG	0.473000												
REV3L	5980	broad.mit.edu	37	6	111652933	111652933	+	Silent	SNP	A	A	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr6:111652933A>G	uc003puy.3	-	24	8303	c.7980T>C	c.(7978-7980)CTT>CTC	p.L2660L	REV3L_uc003pux.3_Silent_p.L2582L|REV3L_uc003puz.3_Silent_p.L2582L|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2660					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TAACTTGGTAAAGTAAATCTG	0.363000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage				
PDE1C	5137	broad.mit.edu	37	7	31917586	31917586	+	Missense_Mutation	SNP	T	T	G			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr7:31917586T>G	uc003tcm.1	-	5	958	c.489A>C	c.(487-489)TTA>TTC	p.L163F	PDE1C_uc003tcn.1_Missense_Mutation_p.L163F|PDE1C_uc003tco.1_Missense_Mutation_p.L223F|PDE1C_uc003tcr.2_Missense_Mutation_p.L163F|PDE1C_uc003tcs.2_Missense_Mutation_p.L163F	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	163					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			GTATTACCTTTAATGCCTCAA	0.333000												
KIAA1324L	222223	broad.mit.edu	37	7	86542424	86542424	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr7:86542424C>T	uc011kha.1	-	14	2013	c.1828G>A	c.(1828-1830)GGT>AGT	p.G610S	KIAA1324L_uc003uif.1_Missense_Mutation_p.G370S|KIAA1324L_uc011kgz.1_Missense_Mutation_p.G496S|KIAA1324L_uc003uie.2_Missense_Mutation_p.G443S	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	610	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					TGTTCAGAACCGAGGGCACAG	0.507000												
OR2F2	135948	broad.mit.edu	37	7	143632642	143632642	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr7:143632642C>T	uc011ktv.1	+	1	317	c.317C>T	c.(316-318)GCC>GTC	p.A106V		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					TTCTCCCTGGCCTTGGGTGGG	0.547000												
PDIA4	9601	broad.mit.edu	37	7	148701057	148701057	+	Silent	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr7:148701057G>A	uc003wff.2	-	10	2049	c.1767C>T	c.(1765-1767)GAC>GAT	p.D589D		NM_004911	NP_004902	P13667	PDIA4_HUMAN	protein disulfide isomerase A4 precursor	589	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			lung(5)|ovary(1)	6	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			CGCTGGGGACGTCGTTGGCAG	0.577000												
GALNTL5	168391	broad.mit.edu	37	7	151684285	151684285	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr7:151684285C>T	uc003wkp.2	+	5	800	c.577C>T	c.(577-579)CGG>TGG	p.R193W	GALNTL5_uc003wkq.2_Intron|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.R82W	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	193	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		GGAAACTTTTCGGGGAAAGGT	0.378000												
PTPRN2	5799	broad.mit.edu	37	7	157931093	157931093	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr7:157931093C>T	uc003wno.2	-	7	1146	c.1025G>A	c.(1024-1026)GGC>GAC	p.G342D	PTPRN2_uc003wnp.2_Missense_Mutation_p.G325D|PTPRN2_uc003wnq.2_Missense_Mutation_p.G342D|PTPRN2_uc003wnr.2_Missense_Mutation_p.G304D|PTPRN2_uc011kwa.1_Missense_Mutation_p.G365D	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	342	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ATGGTCCACGCCTTGCATCAG	0.672000												
PTPRN2	5799	broad.mit.edu	37	7	157959936	157959936	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr7:157959936C>T	uc003wno.2	-	6	718	c.597G>A	c.(595-597)ACG>ACA	p.T199T	PTPRN2_uc003wnp.2_Silent_p.T182T|PTPRN2_uc003wnq.2_Silent_p.T199T|PTPRN2_uc003wnr.2_Silent_p.T161T|PTPRN2_uc011kwa.1_Silent_p.T222T	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	199	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TCAGCGCAGACGTGTGGGCCA	0.622000												
SLC25A37	51312	broad.mit.edu	37	8	23429083	23429083	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr8:23429083C>T	uc003xdo.2	+	4	885	c.732C>T	c.(730-732)GCC>GCT	p.A244A	SLC25A37_uc003xdp.2_RNA|SLC25A37_uc010ltz.2_RNA|SLC25A37_uc003xdq.2_RNA|SLC25A37_uc003xdr.1_RNA|uc003xds.2_5'Flank	NM_016612	NP_057696	Q9NYZ2	MFRN1_HUMAN	solute carrier family 25, member 37	244	Solcar 3.|Helical; Name=5; (Potential).				ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane					0		Prostate(55;0.114)		Colorectal(74;0.0198)|COAD - Colon adenocarcinoma(73;0.0751)		GCGGGCTGGCCGGGGCCCTCG	0.647000												
KCNU1	157855	broad.mit.edu	37	8	36698509	36698509	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr8:36698509C>T	uc010lvw.2	+	16	1778	c.1691C>T	c.(1690-1692)ACG>ATG	p.T564M	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	564	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TCCCTCTTTACGGATGGTTTC	0.403000												
MCM4	4173	broad.mit.edu	37	8	48889314	48889314	+	Silent	SNP	T	T	C			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr8:48889314T>C	uc003xqk.1	+	17	2663	c.2568T>C	c.(2566-2568)ACT>ACC	p.T856T	MCM4_uc003xql.1_Silent_p.T856T|MCM4_uc011ldi.1_Silent_p.T843T	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	856					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TGACAGTGACTGGGAAGACCG	0.493000												
NSMAF	8439	broad.mit.edu	37	8	59535981	59535981	+	Silent	SNP	A	A	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr8:59535981A>T	uc003xtt.2	-	8	673	c.459T>A	c.(457-459)CTT>CTA	p.L153L	NSMAF_uc011lee.1_Silent_p.L184L|NSMAF_uc003xtu.2_Silent_p.L153L	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	153					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				ATGCTCTGTGAAGCTACAGTA	0.338000												
EFR3A	23167	broad.mit.edu	37	8	132997219	132997219	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr8:132997219G>A	uc003yte.2	+	16	1982	c.1781G>A	c.(1780-1782)CGT>CAT	p.R594H		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	594						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			ATGTTCCATCGTTGTGGAATC	0.383000												
ZNF658	26149	broad.mit.edu	37	9	40774433	40774433	+	Missense_Mutation	SNP	T	T	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr9:40774433T>A	uc004abs.2	-	5	994	c.842A>T	c.(841-843)AAA>ATA	p.K281I	ZNF658_uc010mmm.1_Missense_Mutation_p.K281I|ZNF658_uc010mmn.1_Missense_Mutation_p.K281I	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AGCGGTGGTTTTGTCACAGGA	0.373000												
PHF2	5253	broad.mit.edu	37	9	96428068	96428068	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr9:96428068G>A	uc004aub.2	+	15	2185	c.2038G>A	c.(2038-2040)GTG>ATG	p.V680M	PHF2_uc011lug.1_Missense_Mutation_p.V563M|PHF2_uc004auc.2_Missense_Mutation_p.V99M	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	680					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		GTATGAGTACGTGTCGGATGA	0.587000												
ANKS6	203286	broad.mit.edu	37	9	101533322	101533322	+	Missense_Mutation	SNP	C	C	T	rs138782444	by1000genomes	TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr9:101533322C>T	uc004ayu.2	-	10	1849	c.1828G>A	c.(1828-1830)GTC>ATC	p.V610I	ANKS6_uc004ayt.2_Missense_Mutation_p.V309I|ANKS6_uc004ayv.1_Missense_Mutation_p.V72I|ANKS6_uc004ayw.1_Missense_Mutation_p.V192I|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	610										ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				ACAGGCCTGACGGGTGTCTAC	0.577000												
TNC	3371	broad.mit.edu	37	9	117825304	117825304	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr9:117825304G>A	uc004bjj.3	-	13	4287	c.3925C>T	c.(3925-3927)CGT>TGT	p.R1309C	TNC_uc010mvf.2_Missense_Mutation_p.R1309C	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1309	Fibronectin type-III 8.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						TCCATGGAACGCAGGCTGCCA	0.592000												
ASTN2	23245	broad.mit.edu	37	9	119976939	119976939	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr9:119976939C>T	uc004bjs.1	-	3	814	c.713G>A	c.(712-714)CGC>CAC	p.R238H	ASTN2_uc004bjr.1_Missense_Mutation_p.R238H|ASTN2_uc004bjt.1_Missense_Mutation_p.R238H	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	238	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CTGGGGGATGCGGCGACGCTT	0.637000												
CACNA1B	774	broad.mit.edu	37	9	140777327	140777327	+	Silent	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr9:140777327C>T	uc004cog.2	+	3	667	c.522C>T	c.(520-522)GTC>GTT	p.V174V	uc004cof.1_RNA	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	174	Helical; Name=S3 of repeat I; (Potential).|I.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCGTGGTCGTCCTCACAGGGT	0.612000												
GRPR	2925	broad.mit.edu	37	X	16142390	16142390	+	Missense_Mutation	SNP	G	G	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chrX:16142390G>T	uc004cxj.2	+	1	967	c.314G>T	c.(313-315)AGA>ATA	p.R105I		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	105	Extracellular (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					CTGGCTGACAGATGGCTATTT	0.532000											OREG0019682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
FAM47C	442444	broad.mit.edu	37	X	37029349	37029349	+	Missense_Mutation	SNP	C	C	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chrX:37029349C>A	uc004ddl.1	+	1	2880	c.2866C>A	c.(2866-2868)CCT>ACT	p.P956T		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	956										ovary(3)	3						AAGTGATGAACCTTTGATTGA	0.443000												
RPS6KA6	27330	broad.mit.edu	37	X	83359569	83359569	+	Missense_Mutation	SNP	G	G	A			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chrX:83359569G>A	uc004eej.1	-	17	1629	c.1552C>T	c.(1552-1554)CGG>TGG	p.R518W	RPS6KA6_uc011mqt.1_Missense_Mutation_p.R518W|RPS6KA6_uc011mqu.1_Missense_Mutation_p.R415W	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	518	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						CTAGCCTCCCGTTCCGAGAAA	0.353000												
MUM1L1	139221	broad.mit.edu	37	X	105450999	105450999	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chrX:105450999C>T	uc004emf.1	+	4	2223	c.1574C>T	c.(1573-1575)CCG>CTG	p.P525L	MUM1L1_uc004emg.1_Missense_Mutation_p.P525L	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	525										ovary(2)|pancreas(1)|skin(1)	4						GCCAGGGAACCGATGGCTGTA	0.448000												
ODZ1	10178	broad.mit.edu	37	X	123540329	123540329	+	Missense_Mutation	SNP	C	C	T			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chrX:123540329C>T	uc004euj.2	-	25	5036	c.4972G>A	c.(4972-4974)GAG>AAG	p.E1658K	ODZ1_uc011muj.1_Missense_Mutation_p.E1664K|ODZ1_uc010nqy.2_Missense_Mutation_p.E1665K	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1658	Extracellular (Potential).|YD 5.				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AGGTGTCCCTCGGGGTCATAC	0.488000												
EZH1	2145	broad.mit.edu	37	17	40864502	40864503	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-CD-8528-01A-11D-2340-08	TCGA-CD-8528-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1428870-65bf-45a5-b321-578ad94288c1	07bd0343-e5c6-48bf-ae2a-1d3d56b624ea	g.chr17:40864502_40864503delCT	uc002iaz.2	-	12	1350_1351	c.1205_1206delAG	c.(1204-1206)GAGfs	p.E402fs	EZH1_uc002iba.2_Frame_Shift_Del_p.E393fs|EZH1_uc010wgt.1_Frame_Shift_Del_p.E332fs|EZH1_uc010wgu.1_Frame_Shift_Del_p.E408fs|EZH1_uc010wgv.1_Frame_Shift_Del_p.E362fs|EZH1_uc010wgw.1_Frame_Shift_Del_p.E263fs|EZH1_uc010cyp.2_Frame_Shift_Del_p.E303fs|EZH1_uc010cyq.2_Frame_Shift_Del_p.E319fs|EZH1_uc010cyo.1_Frame_Shift_Del_p.E65fs|EZH1_uc010cyr.1_Frame_Shift_Del_p.E54fs	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	402					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		GAGAGTTAGCCTCTGAGAAGGG	0.465