Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CD1D	912	broad.mit.edu	37	1	158151309	158151309	+	Silent	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr1:158151309G>A	uc001frr.2	+	3	625	c.126G>A	c.(124-126)ACG>ACA	p.T42T	CD1D_uc009wsr.1_Silent_p.T42T|CD1D_uc009wss.2_Silent_p.T42T|CD1D_uc009wst.1_5'UTR	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	42	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					GCAGCTGGACGCGCACCGACG	0.627000												
OR6N2	81442	broad.mit.edu	37	1	158746540	158746540	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr1:158746540C>A	uc010pir.1	-	1	886	c.886G>T	c.(886-888)GAA>TAA	p.E296*		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TTAATGATTTCCTTGTTACGA	0.408000												
PITRM1	10531	broad.mit.edu	37	10	3185599	3185599	+	Missense_Mutation	SNP	G	G	A	rs35046873	by1000genomes	TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr10:3185599G>A	uc010qah.1	-	20	2365	c.2333C>T	c.(2332-2334)ACG>ATG	p.T778M	PITRM1_uc001igr.1_Missense_Mutation_p.T876M|PITRM1_uc001igs.1_Translation_Start_Site|PITRM1_uc001igt.1_Missense_Mutation_p.T876M|PITRM1_uc009xhv.1_Missense_Mutation_p.T442M|PITRM1_uc001igu.1_Missense_Mutation_p.T802M|PITRM1_uc010qai.1_Missense_Mutation_p.T847M|uc001igv.1_Intron			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	778					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1						ATCTGGGTCCGTGTAGGGGAC	0.572000												
ANO9	338440	broad.mit.edu	37	11	421037	421037	+	Silent	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr11:421037G>A	uc001lpi.2	-	17	1483	c.1398C>T	c.(1396-1398)CAC>CAT	p.H466H	ANO9_uc001lph.2_Silent_p.H159H|ANO9_uc010qvv.1_Silent_p.H322H	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	466	Extracellular (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						AGCCGCTGGCGTGGCACTGCG	0.647000												
NLRP14	338323	broad.mit.edu	37	11	7064768	7064768	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr11:7064768C>T	uc001mfb.1	+	4	1834	c.1511C>T	c.(1510-1512)TCC>TTC	p.S504F		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	504					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GGGAACCCTTCCTGCCAGCCT	0.408000												
CD6	923	broad.mit.edu	37	11	60783242	60783242	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr11:60783242C>T	uc001nqq.2	+	9	1668	c.1445C>T	c.(1444-1446)TCG>TTG	p.S482L	CD6_uc001nqp.2_Missense_Mutation_p.S482L|CD6_uc001nqr.2_Missense_Mutation_p.S450L|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Intron	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	482	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						GACTCTGGCTCGGACTCAGAC	0.632000												
KCNK4	50801	broad.mit.edu	37	11	64064717	64064717	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr11:64064717G>A	uc001nzj.1	+	4	763	c.440G>A	c.(439-441)CGC>CAC	p.R147H	KCNK4_uc009ypl.1_Missense_Mutation_p.A120T|KCNK4_uc001nzk.1_Missense_Mutation_p.A81T|KCNK4_uc010rnk.1_5'UTR|KCNK4_uc001nzl.1_Missense_Mutation_p.A81T|KCNK4_uc001nzm.3_RNA|KCNK4_uc001nzn.1_Missense_Mutation_p.R147H|KCNK4_uc001nzo.2_Missense_Mutation_p.R147H|KCNK4_uc001nzp.1_5'UTR	NM_033310	NP_201567	Q9NYG8	KCNK4_HUMAN	TRAAK	147	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						TCCTCCCTGCGCCATGGCATC	0.637000												
ATM	472	broad.mit.edu	37	11	108128225	108128225	+	Silent	SNP	A	A	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr11:108128225A>T	uc001pkb.1	+	15	2653	c.2268A>T	c.(2266-2268)GCA>GCT	p.A756A	ATM_uc009yxr.1_Silent_p.A756A	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	756					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGCAATGTGCAGGAGAAAGTA	0.328000			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)		
TBCEL	219899	broad.mit.edu	37	11	120924372	120924372	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr11:120924372G>A	uc009zay.2	+	4	464	c.386G>A	c.(385-387)CGC>CAC	p.R129H	TBCEL_uc001pxo.2_Missense_Mutation_p.R129H|TBCEL_uc001pxp.2_5'UTR|TBCEL_uc001pxq.2_Intron	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	129	LRR 3.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		TCTGGGGTTCGCAAACTTGTC	0.483000												
ANKRD13A	88455	broad.mit.edu	37	12	110474086	110474086	+	Silent	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr12:110474086G>A	uc001tpx.2	+	14	1789	c.1530G>A	c.(1528-1530)TCG>TCA	p.S510S	ANKRD13A_uc010sxw.1_Silent_p.S509S|ANKRD13A_uc001tpy.2_Silent_p.S110S|ANKRD13A_uc001tpz.2_Silent_p.S148S|ANKRD13A_uc001tqa.2_Missense_Mutation_p.E95K	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	510											0						GACCAGCTTCGAATGGAGGGA	0.478000												
RB1	5925	broad.mit.edu	37	13	48951169	48951169	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr13:48951169A>T	uc001vcb.2	+	13	1497	c.1331A>T	c.(1330-1332)CAG>CTG	p.Q444L	RB1_uc010act.1_Missense_Mutation_p.Q145L	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	444	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)|p.Q444H(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATTGGATCACAGGTAACTTGA	0.333000		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)		
ARID4A	5926	broad.mit.edu	37	14	58795012	58795012	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr14:58795012C>T	uc001xdp.2	+	9	894	c.640C>T	c.(640-642)CGA>TGA	p.R214*	ARID4A_uc001xdo.2_Nonsense_Mutation_p.R214*|ARID4A_uc001xdq.2_Nonsense_Mutation_p.R214*	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	214					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						GTGTTTAGTTCGATCATTTAT	0.338000												
TTLL13	440307	broad.mit.edu	37	15	90799471	90799471	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr15:90799471G>A	uc002bpd.1	+	6	935	c.647G>A	c.(646-648)CGA>CAA	p.R216Q	TTLL13_uc002bpe.1_Intron	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	216	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			TTCATTACCCGAAATCCCCGG	0.547000												
GRIN2A	2903	broad.mit.edu	37	16	9934865	9934865	+	Silent	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr16:9934865G>A	uc002czo.3	-	6	1973	c.1425C>T	c.(1423-1425)TAC>TAT	p.Y475Y	GRIN2A_uc010uym.1_Silent_p.Y475Y|GRIN2A_uc010uyn.1_Silent_p.Y318Y|GRIN2A_uc002czr.3_Silent_p.Y475Y	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	475	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATAGAGGTCGTAAGTAAACT	0.423000												
GPT2	84706	broad.mit.edu	37	16	46956237	46956237	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr16:46956237G>A	uc002eel.2	+	9	1215	c.1121G>A	c.(1120-1122)CGC>CAC	p.R374H	GPT2_uc002eem.2_Missense_Mutation_p.R274H|GPT2_uc002een.2_5'Flank	NM_133443	NP_597700	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase 2 isoform 1	374					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTGTCGGTGCGCCTGTGCCCC	0.607000												
DHX38	9785	broad.mit.edu	37	16	72130190	72130190	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr16:72130190G>A	uc002fcb.2	+	2	489	c.134G>A	c.(133-135)CGC>CAC	p.R45H	TXNL4B_uc010cgl.2_5'Flank|TXNL4B_uc002fca.2_5'Flank|TXNL4B_uc010vmn.1_5'Flank|TXNL4B_uc010vmo.1_5'Flank|DHX38_uc010vmp.1_Missense_Mutation_p.R45H|DHX38_uc010cgn.1_5'Flank	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	45					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				CCTGCTCCCCGCCCTTCATTA	0.552000												
SLC6A4	6532	broad.mit.edu	37	17	28539849	28539849	+	Silent	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr17:28539849C>T	uc002hey.3	-	9	1657	c.1113G>A	c.(1111-1113)ACG>ACA	p.T371T	SLC6A4_uc010csg.2_5'Flank	NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	371	Helical; Name=7; (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	AAACGAAGCTCGTCATGCAGT	0.542000												
DCC	1630	broad.mit.edu	37	18	50741940	50741940	+	Silent	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr18:50741940C>T	uc002lfe.1	+	12	2471	c.1884C>T	c.(1882-1884)AAC>AAT	p.N628N	DCC_uc010xdr.1_Silent_p.N476N|DCC_uc010dpf.1_Silent_p.N283N	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	628	Extracellular (Potential).|Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CGCCTCAGAACGTCTCCCTGG	0.398000												
SAFB	6294	broad.mit.edu	37	19	5667069	5667069	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr19:5667069C>T	uc002mcf.2	+	18	2400	c.2347C>T	c.(2347-2349)CGC>TGC	p.R783C	SAFB_uc002mcg.2_Missense_Mutation_p.R783C|SAFB_uc002mce.3_Missense_Mutation_p.R782C|SAFB_uc010xir.1_Missense_Mutation_p.R782C|SAFB_uc010xis.1_Missense_Mutation_p.R714C|SAFB_uc010xit.1_Missense_Mutation_p.R625C|SAFB_uc010xiu.1_Missense_Mutation_p.R582C	NM_002967	NP_002958	Q15424	SAFB1_HUMAN	scaffold attachment factor B	783	Interaction with SAFB2.|Interaction with POLR2A.|Arg-rich.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			ovary(1)|liver(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		TTACCCAGAACGCCATGGAGG	0.612000												
TPO	7173	broad.mit.edu	37	2	1544475	1544475	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr2:1544475G>A	uc002qww.2	+	16	2819	c.2728G>A	c.(2728-2730)GCA>ACA	p.A910T	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.A853T|TPO_uc002qwr.2_Missense_Mutation_p.A910T|TPO_uc002qwx.2_Missense_Mutation_p.A853T|TPO_uc010yio.1_Missense_Mutation_p.A737T|TPO_uc010yip.1_Missense_Mutation_p.A866T|TPO_uc002qwy.1_Missense_Mutation_p.A206T|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	910	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCAGCGGGCCGCAGCTCAGGA	0.642000												
CSRNP3	80034	broad.mit.edu	37	2	166535704	166535704	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr2:166535704A>G	uc002udf.2	+	7	1575	c.1199A>G	c.(1198-1200)CAT>CGT	p.H400R	CSRNP3_uc002udg.2_Missense_Mutation_p.H400R	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	400					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						TTGGGCACCCATGCCGAAGTT	0.378000												
TTN	7273	broad.mit.edu	37	2	179586749	179586749	+	Silent	SNP	A	A	C			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr2:179586749A>C	uc010zfg.1	-	75	19133	c.18909T>G	c.(18907-18909)ACT>ACG	p.T6303T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.T2964T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7230							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTTGACCAAGTGATTCGCA	0.418000												
DNAH7	56171	broad.mit.edu	37	2	196825572	196825572	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr2:196825572C>T	uc002utj.3	-	18	2404	c.2303G>A	c.(2302-2304)CGT>CAT	p.R768H		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	768	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTCATAAAGACGAAGATAAGG	0.403000												
ACSS2	55902	broad.mit.edu	37	20	33508811	33508811	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr20:33508811T>G	uc002xbd.2	+	10	1267	c.1146T>G	c.(1144-1146)TTT>TTG	p.F382L	ACSS2_uc002xbc.2_Missense_Mutation_p.F287L|ACSS2_uc010zum.1_Intron|ACSS2_uc010gey.2_Missense_Mutation_p.F395L|ACSS2_uc002xbe.2_Missense_Mutation_p.F90L|ACSS2_uc002xbf.2_Intron	NM_018677	NP_061147	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	382					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGGGTCAGTTTGAGGGGATTC	0.507000												
SLC12A5	57468	broad.mit.edu	37	20	44664476	44664476	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr20:44664476G>A	uc010zxl.1	+	4	485	c.409G>A	c.(409-411)GTC>ATC	p.V137I	SLC12A5_uc002xra.2_Missense_Mutation_p.V114I|SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.V114I	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	137	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity	p.V114I(1)		ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CATCTTTGGCGTCATCCTCTT	0.602000												
MRAS	22808	broad.mit.edu	37	3	138116252	138116252	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr3:138116252G>A	uc003esh.3	+	3	841	c.280G>A	c.(280-282)GTC>ATC	p.V94I	MRAS_uc011bmi.1_Missense_Mutation_p.V18I|MRAS_uc003esi.3_Missense_Mutation_p.V94I|MRAS_uc011bmj.1_Missense_Mutation_p.V18I	NM_012219	NP_036351	O14807	RASM_HUMAN	muscle RAS oncogene homolog precursor	94					actin cytoskeleton organization|muscle organ development|Ras protein signal transduction	intracellular|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CGTCTACTCCGTCACTGACAA	0.577000												
KLHL24	54800	broad.mit.edu	37	3	183368817	183368817	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr3:183368817A>C	uc003flv.2	+	3	968	c.673A>C	c.(673-675)AAA>CAA	p.K225Q	KLHL24_uc003flw.2_Missense_Mutation_p.K225Q|KLHL24_uc003flx.2_Missense_Mutation_p.K225Q	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	225	BACK.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			TGTTATTGGTAAAGAGGAGAT	0.423000												
TP63	8626	broad.mit.edu	37	3	189582154	189582154	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr3:189582154C>T	uc003fry.2	+	5	802	c.713C>T	c.(712-714)ACG>ATG	p.T238M	TP63_uc003frx.2_Missense_Mutation_p.T238M|TP63_uc003frz.2_Missense_Mutation_p.T238M|TP63_uc010hzc.1_Missense_Mutation_p.T238M|TP63_uc003fsa.2_Missense_Mutation_p.T144M|TP63_uc003fsb.2_Missense_Mutation_p.T144M|TP63_uc003fsc.2_Missense_Mutation_p.T144M|TP63_uc003fsd.2_Missense_Mutation_p.T144M|TP63_uc010hzd.1_Missense_Mutation_p.T59M|TP63_uc003fse.1_Missense_Mutation_p.T119M	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	238					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GAGCACGTCACGGAGGTGGTG	0.517000									Hay-Wells_syndrome	HNSCC(45;0.13)		
WDFY3	23001	broad.mit.edu	37	4	85715865	85715865	+	Silent	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr4:85715865G>A	uc003hpd.2	-	21	3702	c.3294C>T	c.(3292-3294)TCC>TCT	p.S1098S		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1098						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AACTTAAGCCGGAGGGAGGAG	0.348000												
MARCH1	55016	broad.mit.edu	37	4	164466833	164466833	+	Silent	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr4:164466833G>A	uc003iqs.1	-	7	1463	c.486C>T	c.(484-486)CAC>CAT	p.H162H	MARCH1_uc003iqr.1_Silent_p.H145H	NM_017923	NP_060393	Q8TCQ1	MARH1_HUMAN	membrane-associated RING-CH protein I	162	Helical; (Potential).				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCGCGATTACGTGGAATGTGA	0.428000												
PCSK1	5122	broad.mit.edu	37	5	95768636	95768636	+	Silent	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr5:95768636C>T	uc003kls.1	-	1	317	c.111G>A	c.(109-111)GCG>GCA	p.A37A		NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	37					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGGGGATCTCCGCTGCCCATT	0.547000												
PCDHA11	56138	broad.mit.edu	37	5	140250589	140250589	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr5:140250589G>A	uc003lia.2	+	1	2759	c.1901G>A	c.(1900-1902)CGT>CAT	p.R634H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R634H	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	634	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCACAACGCGTGCCCTGGAC	0.667000												
PCDHB6	56130	broad.mit.edu	37	5	140530549	140530549	+	Silent	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr5:140530549C>T	uc003lir.2	+	1	711	c.711C>T	c.(709-711)AAC>AAT	p.N237N	PCDHB6_uc011dah.1_Silent_p.N101N	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	237	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAATGACAACGTCCCCGAGT	0.562000												
PCDHB11	56125	broad.mit.edu	37	5	140581312	140581312	+	Silent	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr5:140581312C>T	uc003liy.2	+	1	1965	c.1965C>T	c.(1963-1965)ACC>ACT	p.T655T	PCDHB11_uc011daj.1_Silent_p.T290T	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	655	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTCGGCCACCGCCACGCTGC	0.721000												
FAM71B	153745	broad.mit.edu	37	5	156592829	156592829	+	Silent	SNP	T	T	C			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr5:156592829T>C	uc003lwn.2	-	1	451	c.351A>G	c.(349-351)CTA>CTG	p.L117L		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	117						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCGTGAGCTCTAGAGTCTTGA	0.527000												
DLL1	28514	broad.mit.edu	37	6	170592163	170592163	+	Silent	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr6:170592163G>A	uc003qxm.2	-	10	2549	c.2079C>T	c.(2077-2079)GAC>GAT	p.D693D		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	693	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		AACAGCCCGAGTCCGGCCTTT	0.463000												
HOXA13	3209	broad.mit.edu	37	7	27239615	27239615	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr7:27239615C>A	uc003szb.1	-	1	111	c.82G>T	c.(82-84)GCC>TCC	p.A28S	uc003szc.1_5'Flank	NM_000522	NP_000513	P31271	HXA13_HUMAN	homeobox A13	28					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)	1						AGCTCGTCGGCCACCAGGCCG	0.408000			T	NUP98	AML							
TBL2	26608	broad.mit.edu	37	7	72984991	72984991	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr7:72984991C>T	uc003tyh.2	-	7	1324	c.1190G>A	c.(1189-1191)CGG>CAG	p.R397Q	TBL2_uc011kex.1_Missense_Mutation_p.R361Q|TBL2_uc010lbg.2_Missense_Mutation_p.R302Q|TBL2_uc003tyi.2_Missense_Mutation_p.R232Q|TBL2_uc011key.1_Missense_Mutation_p.R268Q|TBL2_uc010lbh.2_Missense_Mutation_p.R302Q	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	397	WD 7.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				GTGAAACAGCCGCACCGCCCG	0.632000												
TFPI2	7980	broad.mit.edu	37	7	93519622	93519622	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr7:93519622G>A	uc003umy.1	-	2	173	c.98C>T	c.(97-99)GCG>GTG	p.A33V	GNGT1_uc003umx.1_Intron|TFPI2_uc003umz.1_Missense_Mutation_p.A33V|TFPI2_uc003una.1_Intron|TFPI2_uc003unb.1_Missense_Mutation_p.A33V|TFPI2_uc010lfg.1_Intron	NM_006528	NP_006519	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2 precursor	33					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity			pancreas(1)	1	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			ACAGATCTCCGCGTTATTTCC	0.572000												
ZNF775	285971	broad.mit.edu	37	7	150093795	150093796	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr7:150093795_150093796CC>AT	uc003whf.1	+	3	351_352	c.226_227CC>AT	c.(226-228)CCT>ATT	p.P76I		NM_173680	NP_775951	Q96BV0	ZN775_HUMAN	zinc finger protein 775	76					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.0173)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAGGTGGGCCCCTCCCACTGAG	0.703000												
ZMAT4	79698	broad.mit.edu	37	8	40554842	40554842	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr8:40554842C>T	uc003xnr.2	-	4	417	c.271G>A	c.(271-273)GAT>AAT	p.D91N	ZMAT4_uc003xns.2_Missense_Mutation_p.D91N	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	91	Matrin-type 2.					nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			TAATGGGAATCGGCCACCACC	0.502000												
TOX	9760	broad.mit.edu	37	8	59728015	59728015	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr8:59728015G>A	uc003xtw.1	-	7	1495	c.1274C>T	c.(1273-1275)CCG>CTG	p.P425L		NM_014729	NP_055544	O94900	TOX_HUMAN	thymus high mobility group box protein TOX	425						nucleus	DNA binding			kidney(2)|lung(1)|skin(1)	4		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GTGAAGAGGCGGGCTGATCTG	0.587000												
PI15	51050	broad.mit.edu	37	8	75757681	75757681	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr8:75757681G>A	uc003yal.2	+	5	769	c.590G>A	c.(589-591)TGG>TAG	p.W197*	uc003yak.1_Intron|PI15_uc003yam.2_Nonsense_Mutation_p.W197*	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	197						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			ATGAATGTTTGGGGATCTGTG	0.413000												
CIZ1	25792	broad.mit.edu	37	9	130940663	130940663	+	Silent	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr9:130940663C>T	uc004btt.2	-	9	1768	c.1605G>A	c.(1603-1605)GCG>GCA	p.A535A	CIZ1_uc004btr.2_Silent_p.A507A|CIZ1_uc004bts.2_Silent_p.A506A|CIZ1_uc011maq.1_Silent_p.A474A|CIZ1_uc004btu.2_Silent_p.A455A|CIZ1_uc011mar.1_Silent_p.A434A|CIZ1_uc011mas.1_Silent_p.A565A|CIZ1_uc004btw.2_Silent_p.A479A|CIZ1_uc004btv.2_Silent_p.A535A	NM_001131016	NP_001124488	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1 isoform	535						nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4						GCATCTCTCTCGCTCTGTTTT	0.587000												
C9orf171	389799	broad.mit.edu	37	9	135374767	135374767	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr9:135374767C>T	uc004cbn.2	+	4	460	c.412C>T	c.(412-414)CGC>TGC	p.R138C	C9orf171_uc004cbo.2_Missense_Mutation_p.R102C	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	138										ovary(4)|large_intestine(1)	5						AGCCATCGGACGCTGGAACGT	0.642000												
NELF	26012	broad.mit.edu	37	9	140350865	140350865	+	Silent	SNP	T	T	C			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr9:140350865T>C	uc004cna.2	-	4	934	c.702A>G	c.(700-702)CAA>CAG	p.Q234Q	C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_5'Flank|NELF_uc010nci.2_Silent_p.Q2Q|NELF_uc011mey.1_RNA|NELF_uc011mez.1_Silent_p.Q234Q|NELF_uc004cmz.2_Silent_p.Q234Q|NELF_uc004cnc.2_Silent_p.Q234Q|NELF_uc004cnb.2_Silent_p.Q234Q	NM_001130969	NP_001124441	Q6X4W1	NELF_HUMAN	nasal embryonic LHRH factor isoform a	234						nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)		AGACTCACGCTTGCATAGTTG	0.532000												
MAP7D2	256714	broad.mit.edu	37	X	20081624	20081624	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chrX:20081624G>A	uc004czr.1	-	3	299	c.280C>T	c.(280-282)CGA>TGA	p.R94*	MAP7D2_uc011mji.1_Nonsense_Mutation_p.R50*|MAP7D2_uc010nfo.1_Nonsense_Mutation_p.R94*|MAP7D2_uc011mjj.1_Nonsense_Mutation_p.R94*|MAP7D2_uc004czs.1_Nonsense_Mutation_p.R50*	NM_152780	NP_689993	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	94	Potential.									ovary(2)|breast(1)	3						TTTCGCCATCGCTCCTCCATT	0.547000												
PLXNB3	5365	broad.mit.edu	37	X	153036951	153036951	+	Silent	SNP	C	C	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chrX:153036951C>T	uc004fii.2	+	14	2532	c.2358C>T	c.(2356-2358)TAC>TAT	p.Y786Y	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Silent_p.Y468Y|PLXNB3_uc010nuk.2_Silent_p.Y809Y|PLXNB3_uc011mzd.1_Silent_p.Y425Y|PLXNB3_uc004fij.1_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	786	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					TGATCCTGTACGACTGCGCCA	0.667000												
BZRAP1	9256	broad.mit.edu	37	17	56386384	56386385	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-A4J2-01A-21D-A25D-08	TCGA-BR-A4J2-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c0cd0e3b-9ffe-4231-a81d-1be43a73c495	2dda3e71-60cd-4ef0-8717-e4ea2fb2fa58	g.chr17:56386383_56386384C>CT	uc002ivx.4	-	21	5120_5121	c.4249_4250G>AG	c.(4249-4251)agcfs	p.S1417fs	BZRAP1_uc002ivw.3_5'Flank|BZRAP1_uc010dcs.3_Frame_Shift_Ins_p.S1357fs|BZRAP1_uc010wnt.2_Frame_Shift_Ins_p.S1417fs	NM_004758	NP_004749	O95153	RIMB1_HUMAN	Homo sapiens benzodiazapine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant 1, mRNA.	1417						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGCCTGCGGCTTGGGGGCTTC	0.653