Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
RNF19B	127544	broad.mit.edu	37	1	33402454	33402454	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr1:33402454C>T	uc010oho.1	-	9	2152	c.2152G>A	c.(2152-2154)GAG>AAG	p.E718K	RNF19B_uc001bwm.3_3'UTR|RNF19B_uc010ohp.1_Missense_Mutation_p.E717K	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	718						integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GTTTGTCCCTCGGCTAGGGCA	0.567000												
SPTA1	6708	broad.mit.edu	37	1	158606544	158606544	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr1:158606544A>C	uc001fst.1	-	37	5396	c.5197T>G	c.(5197-5199)TTG>GTG	p.L1733V		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1733	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACTCGTATCAACTTCTCCCTA	0.473000												
FCRLA	84824	broad.mit.edu	37	1	161682978	161682978	+	Silent	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr1:161682978G>A	uc001gbe.2	+	6	1199	c.957G>A	c.(955-957)CCG>CCA	p.P319P	FCRLA_uc001gbd.2_Silent_p.P313P|FCRLA_uc001gbf.2_Silent_p.P224P|FCRLA_uc001gbg.2_Silent_p.P173P|FCRLA_uc009wuo.2_Silent_p.P179P|FCRLA_uc009wup.2_Silent_p.P129P|FCRLA_uc009wuq.2_Silent_p.P78P	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	296	Pro-rich.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			TGCCTCCGCCGCCAACCCCAT	0.572000												
OR2L8	391190	broad.mit.edu	37	1	248112415	248112415	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr1:248112415C>A	uc001idt.1	+	1	256	c.256C>A	c.(256-258)CAT>AAT	p.H86N	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TGATTTTCTGCATGGAAACAA	0.448000												
RET	5979	broad.mit.edu	37	10	43612057	43612057	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr10:43612057G>A	uc001jal.2	+	12	2352	c.2162G>A	c.(2161-2163)CGG>CAG	p.R721Q	RET_uc001jak.1_Missense_Mutation_p.R721Q|RET_uc010qez.1_Missense_Mutation_p.R467Q	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	721	Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	GAATTCCCTCGGAAGAACTTG	0.512000		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma			
DLG5	9231	broad.mit.edu	37	10	79581291	79581291	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr10:79581291G>A	uc001jzk.2	-	15	3021	c.2951C>T	c.(2950-2952)ACA>ATA	p.T984I	DLG5_uc001jzi.2_5'Flank|DLG5_uc001jzj.2_Intron|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.T588I	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	984	Pro-rich.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TTTGGGGGGTGTCTGGGGGCG	0.552000												
NRG3	10718	broad.mit.edu	37	10	84498378	84498378	+	Silent	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr10:84498378G>A	uc001kco.2	+	3	1026	c.999G>A	c.(997-999)CCG>CCA	p.P333P	NRG3_uc010qlz.1_Silent_p.P333P|NRG3_uc001kcp.2_Silent_p.P112P|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	333	Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AATTTCTGCCGAAAACTGATT	0.398000												
GRID1	2894	broad.mit.edu	37	10	87487712	87487712	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr10:87487712A>G	uc001kdl.1	-	10	1534	c.1433T>C	c.(1432-1434)CTG>CCG	p.L478P	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.L49P	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	478	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TTTAAAGCCCAGAGCCTTGGC	0.537000										Multiple Myeloma(13;0.14)		
OR52J3	119679	broad.mit.edu	37	11	5068425	5068425	+	Missense_Mutation	SNP	C	C	T	rs142062445	byFrequency	TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr11:5068425C>T	uc010qyv.1	+	1	670	c.670C>T	c.(670-672)CGT>TGT	p.R224C		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTACATTCTCCGTGCTGTCTT	0.448000												
HBG2	3048	broad.mit.edu	37	11	5275655	5275655	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr11:5275655A>G	uc001mai.1	-	2	619	c.182T>C	c.(181-183)GTC>GCC	p.V61A	HBG2_uc001mak.1_RNA|HBG2_uc001maj.1_Missense_Mutation_p.V61A	NM_000559	NP_000550	P69892	HBG2_HUMAN	A-gamma globin	61					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGTGCCTTGACTTTGGGGTT	0.537000												
PGR	5241	broad.mit.edu	37	11	100922231	100922231	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr11:100922231A>T	uc001pgh.2	-	5	3024	c.2281T>A	c.(2281-2283)TTT>ATT	p.F761I	PGR_uc001pgg.2_Missense_Mutation_p.F142I|PGR_uc001pgi.2_Missense_Mutation_p.F659I|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	761	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CCTAGACCAAACACCATTAAG	0.348000												
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr17:7578457C>T	uc002gim.2	-	5	667	c.473G>A	c.(472-474)CGC>CAC	p.R158H	TP53_uc002gig.1_Missense_Mutation_p.R158H|TP53_uc002gih.2_Missense_Mutation_p.R158H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26H|TP53_uc010cng.1_Missense_Mutation_p.R26H|TP53_uc002gii.1_Missense_Mutation_p.R26H|TP53_uc010cnh.1_Missense_Mutation_p.R158H|TP53_uc010cni.1_Missense_Mutation_p.R158H|TP53_uc002gij.2_Missense_Mutation_p.R158H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65H|TP53_uc002gio.2_Missense_Mutation_p.R26H|TP53_uc010vug.1_Missense_Mutation_p.R119H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
ATP1A3	478	broad.mit.edu	37	19	42490135	42490135	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr19:42490135G>A	uc002osg.2	-	6	641	c.487C>T	c.(487-489)CGG>TGG	p.R163W	ATP1A3_uc010xwf.1_Missense_Mutation_p.R174W|ATP1A3_uc010xwg.1_Missense_Mutation_p.R133W|ATP1A3_uc010xwh.1_Missense_Mutation_p.R176W|ATP1A3_uc002osh.2_Missense_Mutation_p.R163W	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	163	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TCACCTTCCCGGATCACCAGG	0.622000												
C20orf26	26074	broad.mit.edu	37	20	20257982	20257982	+	Silent	SNP	C	C	T			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr20:20257982C>T	uc002wru.2	+	22	2752	c.2676C>T	c.(2674-2676)GCC>GCT	p.A892A	C20orf26_uc010zse.1_Silent_p.A872A|C20orf26_uc002wrw.2_RNA	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	892										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CGCTAGGAGCCGCCGGAGTCA	0.667000												
GK2	2712	broad.mit.edu	37	4	80328138	80328138	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr4:80328138T>C	uc003hlu.2	-	1	1235	c.1217A>G	c.(1216-1218)GAG>GGG	p.E406G		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	406					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						TTCCAAAATCTCTCGGGTTTG	0.443000												
RXFP1	59350	broad.mit.edu	37	4	159493865	159493865	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr4:159493865G>T	uc003ipz.2	+	2	147	c.65G>T	c.(64-66)GGA>GTA	p.G22V	RXFP1_uc010iqj.1_5'UTR|RXFP1_uc011cja.1_5'UTR|RXFP1_uc010iqo.2_Missense_Mutation_p.G22V|RXFP1_uc011cjb.1_5'UTR|RXFP1_uc010iqk.2_5'UTR|RXFP1_uc011cjc.1_5'UTR|RXFP1_uc011cjd.1_5'UTR|RXFP1_uc010iql.2_5'UTR|RXFP1_uc011cje.1_Missense_Mutation_p.G22V|RXFP1_uc010iqm.2_Missense_Mutation_p.G22V|RXFP1_uc011cjf.1_5'UTR|RXFP1_uc010iqn.2_Intron	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	22	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		CATGGGGGTGGACAGGATGTC	0.488000												
PCDHB9	56127	broad.mit.edu	37	5	140568790	140568790	+	Silent	SNP	C	C	T			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr5:140568790C>T	uc003liw.1	+	3	1899	c.1899C>T	c.(1897-1899)CGC>CGT	p.R633R		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	633	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAGCGAGCGCGACGCAGCCA	0.682000												
PCDHGB3	56102	broad.mit.edu	37	5	140751697	140751697	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr5:140751697C>T	uc003ljw.1	+	1	1736	c.1736C>T	c.(1735-1737)CCG>CTG	p.P579L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.P579L|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	579	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATATGGTGCCGCGCTCTGCA	0.642000												
PCDHGA12	26025	broad.mit.edu	37	5	140810837	140810837	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr5:140810837G>A	uc003lkt.1	+	1	680	c.511G>A	c.(511-513)GAG>AAG	p.E171K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.E171K	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	171	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGAGCTACGAGCTCAGCCC	0.527000												
ZNF318	24149	broad.mit.edu	37	6	43323429	43323429	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr6:43323429G>A	uc003oux.2	-	4	1721	c.1643C>T	c.(1642-1644)GCA>GTA	p.A548V	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	548					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TACGGATTCTGCCTTTAAATC	0.478000												
PRDM1	639	broad.mit.edu	37	6	106555018	106555018	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr6:106555018C>T	uc003prd.2	+	7	2369	c.2135C>T	c.(2134-2136)GCG>GTG	p.A712V	PRDM1_uc003pre.2_Missense_Mutation_p.A578V	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	712					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		AACTGCGCTGCGGCCCCGGCG	0.582000			D|N|Mis|F|S		DLBCL							
WBSCR17	64409	broad.mit.edu	37	7	71175811	71175811	+	Silent	SNP	T	T	C			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr7:71175811T>C	uc003tvy.2	+	10	1566	c.1566T>C	c.(1564-1566)CCT>CCC	p.P522P	WBSCR17_uc003tvz.2_Silent_p.P221P	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	522	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CACTCCTCCCTGACACCCGCT	0.612000												
TG	7038	broad.mit.edu	37	8	134108585	134108585	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr8:134108585G>A	uc003ytw.2	+	43	7581	c.7540G>A	c.(7540-7542)GAC>AAC	p.D2514N	TG_uc010mdw.2_Missense_Mutation_p.D1273N|TG_uc011ljb.1_Missense_Mutation_p.D883N|TG_uc011ljc.1_Missense_Mutation_p.D647N|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2514					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TTCTCAGGACGACGGGCTCAT	0.562000												
NHS	4810	broad.mit.edu	37	X	17744273	17744273	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chrX:17744273G>A	uc004cxx.2	+	6	2322	c.1984G>A	c.(1984-1986)GTG>ATG	p.V662M	NHS_uc011mix.1_Missense_Mutation_p.V683M|NHS_uc004cxy.2_Missense_Mutation_p.V506M|NHS_uc004cxz.2_Missense_Mutation_p.V485M|NHS_uc004cya.2_Missense_Mutation_p.V385M	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	662						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CAGTGTTTTCGTGACAGAGCA	0.517000												
NKRF	55922	broad.mit.edu	37	X	118724855	118724855	+	Missense_Mutation	SNP	G	G	A	rs144370117		TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chrX:118724855G>A	uc004erq.2	-	2	1186	c.533C>T	c.(532-534)ACG>ATG	p.T178M	NKRF_uc004err.2_Missense_Mutation_p.T178M	NM_017544	NP_060014	O15226	NKRF_HUMAN	transcription factor NRF	178	Active repression domain.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			ovary(1)|central_nervous_system(1)	2						GATTGTCGCCGTTAATTTTTC	0.398000												
SPEF2	79925	broad.mit.edu	37	5	35694396	35694396	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-A4IU-01A-22D-A25D-08	TCGA-BR-A4IU-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f0ced3b1-37d8-4846-86c1-33f0b064f628	332d8b81-8600-42ab-b80c-942c30d8f916	g.chr5:35694396delC	uc003jjo.2	+	13	2017	c.1906delC	c.(1906-1908)CAAfs	p.Q636fs	SPEF2_uc003jjq.3_Frame_Shift_Del_p.Q636fs|SPEF2_uc003jjp.1_Frame_Shift_Del_p.Q127fs	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	636					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAAGGATCCACAACATGTATT	0.323