Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CHD5	26038	broad.mit.edu	37	1	6209393	6209393	+	Silent	SNP	G	G	A	rs147670357		TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr1:6209393G>A	uc001amb.1	-	8	1174	c.1074C>T	c.(1072-1074)TGC>TGT	p.C358C	CHD5_uc001amc.1_5'Flank	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	358	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGCAGGTGTCGCACAGGATGA	0.602000												
ASTN1	460	broad.mit.edu	37	1	176838101	176838101	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr1:176838101C>T	uc001glc.2	-	22	3738	c.3526G>A	c.(3526-3528)GCC>ACC	p.A1176T	ASTN1_uc001glb.1_Missense_Mutation_p.A1176T|ASTN1_uc001gld.1_Missense_Mutation_p.A1176T	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1184					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GTGTTGTAGGCGGTCTGCTGC	0.468000												
SIPA1L2	57568	broad.mit.edu	37	1	232551275	232551275	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr1:232551275C>A	uc001hvg.2	-	17	4885	c.4727G>T	c.(4726-4728)TGG>TTG	p.W1576L	SIPA1L2_uc001hvf.2_Missense_Mutation_p.W650L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1576					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GAGGTGGGTCCAATCTAACCC	0.572000												
RGS7	6000	broad.mit.edu	37	1	240975337	240975337	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr1:240975337T>G	uc001hyv.2	-	14	1293	c.963A>C	c.(961-963)GAA>GAC	p.E321D	RGS7_uc010pyh.1_Missense_Mutation_p.E295D|RGS7_uc010pyj.1_Missense_Mutation_p.E237D|RGS7_uc001hyu.2_Missense_Mutation_p.E321D|RGS7_uc009xgn.1_Missense_Mutation_p.E268D|RGS7_uc001hyw.2_Missense_Mutation_p.E321D|RGS7_uc001hyt.2_Missense_Mutation_p.E153D	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	321					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GCTGGCTCGGTTCTTTGCTAT	0.398000												
OR2M5	127059	broad.mit.edu	37	1	248308867	248308867	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr1:248308867A>G	uc010pze.1	+	1	418	c.418A>G	c.(418-420)ATT>GTT	p.I140V		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GAGACCCAAAATTTGTGGACT	0.468000												
PCDH15	65217	broad.mit.edu	37	10	55582245	55582245	+	Silent	SNP	A	A	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr10:55582245A>G	uc001jju.1	-	33	5636	c.5241T>C	c.(5239-5241)CTT>CTC	p.L1747L	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.L1744L|PCDH15_uc010qhw.1_Silent_p.L1707L|PCDH15_uc010qhx.1_Silent_p.L1678L|PCDH15_uc010qhy.1_Silent_p.L1754L|PCDH15_uc010qhz.1_Silent_p.L1749L|PCDH15_uc010qia.1_Silent_p.L1727L|PCDH15_uc010qib.1_Silent_p.L1724L	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1747	Poly-Pro.|Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				gaggagggggaaggggaCAGG	0.179000										HNSCC(58;0.16)		
HIF1AN	55662	broad.mit.edu	37	10	102305759	102305759	+	Silent	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr10:102305759C>T	uc001krj.3	+	5	858	c.783C>T	c.(781-783)TAC>TAT	p.Y261Y		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	261	JmjC.|Interaction with HIF1A.|Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		TGGTTGGTTACGAAACAGTGG	0.453000												
OR5AS1	219447	broad.mit.edu	37	11	55798495	55798495	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr11:55798495G>T	uc010riw.1	+	1	601	c.601G>T	c.(601-603)GCT>TCT	p.A201S		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					TCTGCTCTTTGCTTTGTGCAG	0.423000												
CHFR	55743	broad.mit.edu	37	12	133435715	133435715	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr12:133435715C>G	uc001ulf.2	-	8	970	c.886G>C	c.(886-888)GAC>CAC	p.D296H	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.D284H|CHFR_uc010tbs.1_Missense_Mutation_p.D296H|CHFR_uc001uld.2_Missense_Mutation_p.D255H|CHFR_uc010tbt.1_Missense_Mutation_p.D204H	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	296					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TCCATCTTGTCTGGCTTCCCA	0.597000												
BRCA2	675	broad.mit.edu	37	13	32911853	32911853	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr13:32911853T>A	uc001uub.1	+	11	3588	c.3361T>A	c.(3361-3363)TCA>ACA	p.S1121T		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1121					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ATTAGAAGAATCAGGAAGTCA	0.338000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)		
BRCA2	675	broad.mit.edu	37	13	32911967	32911967	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr13:32911967T>A	uc001uub.1	+	11	3702	c.3475T>A	c.(3475-3477)TGC>AGC	p.C1159S		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1159					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TTCTGAGGAATGCAGAGATGC	0.388000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)		
OCA2	4948	broad.mit.edu	37	15	28228574	28228574	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr15:28228574A>C	uc001zbh.3	-	14	1530	c.1420T>G	c.(1420-1422)TTC>GTC	p.F474V	OCA2_uc010ayv.2_Missense_Mutation_p.F450V	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	474	Extracellular (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ATGTTTGTGAAGATCACTTCT	0.468000									Oculocutaneous_Albinism			
TMEM85	51234	broad.mit.edu	37	15	34517759	34517759	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr15:34517759G>T	uc001zhq.2	+	2	180	c.109G>T	c.(109-111)GGC>TGC	p.G37C	TMEM85_uc010ucb.1_Missense_Mutation_p.G37C|TMEM85_uc001zhr.2_RNA|TMEM85_uc001zhs.2_Missense_Mutation_p.G37C|TMEM85_uc010bat.2_Intron	NM_016454	NP_057538	Q5J8M3	TMM85_HUMAN	transmembrane protein 85	37					apoptosis	integral to membrane					0		all_lung(180;1.15e-06)		all cancers(64;1.03e-17)|GBM - Glioblastoma multiforme(113;3.33e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)|Lung(196;0.217)		CCGGGGCAGTGGCCAGGGAGA	0.512000												
ABCC12	94160	broad.mit.edu	37	16	48149471	48149471	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr16:48149471C>T	uc002efc.1	-	13	2190	c.1844G>A	c.(1843-1845)CGC>CAC	p.R615H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	615	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				GTAGACAGCGCGGGCCAGGCT	0.632000												
CDH8	1006	broad.mit.edu	37	16	61687741	61687741	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr16:61687741A>C	uc002eog.1	-	12	2423	c.2171T>G	c.(2170-2172)TTT>TGT	p.F724C		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	724	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TACATTTATAAATTCATCGAC	0.453000												
MYH4	4622	broad.mit.edu	37	17	10368833	10368833	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr17:10368833C>T	uc002gmn.2	-	5	542	c.431G>A	c.(430-432)CGA>CAA	p.R144Q	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	144	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CTTTTTGCCTCGGTAGGCTGT	0.542000												
KRTAP9-9	81870	broad.mit.edu	37	17	39412077	39412077	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr17:39412077C>G	uc010wfq.1	+	3	397	c.395C>G	c.(394-396)ACC>AGC	p.T132S		NM_030975	NP_112237	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	147						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			TGCTGTGAGACCACCTGCTGC	0.607000												
CLUL1	27098	broad.mit.edu	37	18	644941	644941	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr18:644941C>T	uc002kkp.2	+	8	1386	c.1241C>T	c.(1240-1242)TCC>TTC	p.S414F	CLUL1_uc010wys.1_Missense_Mutation_p.S466F|CLUL1_uc002kkq.2_Missense_Mutation_p.S414F	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	414					cell death	extracellular region				ovary(2)	2						GGAAATATTTCCAAACAAGAT	0.348000												
FECH	2235	broad.mit.edu	37	18	55247314	55247314	+	Missense_Mutation	SNP	G	G	A	rs150830931	byFrequency	TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr18:55247314G>A	uc002lgq.3	-	2	302	c.185C>T	c.(184-186)CCG>CTG	p.P62L	FECH_uc002lgp.3_Missense_Mutation_p.P62L|FECH_uc002lgr.3_5'UTR	NM_000140	NP_000131	P22830	HEMH_HUMAN	ferrochelatase isoform b precursor	62			P -> R (in EPP).		generation of precursor metabolites and energy|heme biosynthetic process|protoporphyrinogen IX metabolic process|response to light stimulus	mitochondrial inner membrane|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferrochelatase activity|ferrous iron binding|protein binding			central_nervous_system(1)	1		Colorectal(73;0.227)				CCTCTTCTGCGGTTGAACTTG	0.522000												
ZNF99	7652	broad.mit.edu	37	19	22940942	22940942	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr19:22940942T>C	uc010xrh.1	-	5	1496	c.1496A>G	c.(1495-1497)GAG>GGG	p.E499G		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				GTAGGGTTTCTCCCCAGTATG	0.358000												
PSG2	5670	broad.mit.edu	37	19	43575896	43575896	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr19:43575896G>C	uc002ovr.2	-	4	1013	c.920C>G	c.(919-921)GCC>GGC	p.A307G	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.A307G|PSG2_uc010eiq.1_Missense_Mutation_p.A307G|PSG2_uc002ovs.3_Missense_Mutation_p.A307G|PSG2_uc002ovt.3_Missense_Mutation_p.A307G	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	307	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				CTCGCCAGTGGCTGAGTTACG	0.458000												
DPRX	503834	broad.mit.edu	37	19	54140031	54140031	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr19:54140031C>T	uc002qcf.1	+	3	416	c.365C>T	c.(364-366)ACG>ATG	p.T122M		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	122						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		CTGGTGTACACGGGTCATCGA	0.562000												
ZNF274	10782	broad.mit.edu	37	19	58697083	58697083	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr19:58697083C>G	uc002qrq.1	+	3	497	c.38C>G	c.(37-39)CCA>CGA	p.P13R	ZNF274_uc010yhu.1_RNA|ZNF274_uc010yhv.1_Intron|ZNF274_uc002qrr.1_Missense_Mutation_p.P13R|ZNF274_uc002qrs.1_Intron|ZNF274_uc010eum.1_5'UTR	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	13					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		TTTTAGGAACCAGTGACCTTT	0.512000												
PXDN	7837	broad.mit.edu	37	2	1677547	1677547	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr2:1677547A>C	uc002qxa.2	-	9	950	c.886T>G	c.(886-888)TTG>GTG	p.L296V	PXDN_uc002qxb.1_Missense_Mutation_p.L296V|PXDN_uc002qxc.1_Missense_Mutation_p.L113V	NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	296	Ig-like C2-type 1.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCGTCCAGCAAGTTTAGGCGG	0.502000												
KCNIP3	30818	broad.mit.edu	37	2	96040939	96040939	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr2:96040939G>A	uc002sup.2	+	5	545	c.430G>A	c.(430-432)GGG>AGG	p.G144R	KCNIP3_uc002suq.2_Missense_Mutation_p.G118R	NM_013434	NP_038462	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3 isoform 1	144	EF-hand 2.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			breast(2)|ovary(1)	3				READ - Rectum adenocarcinoma(193;0.13)		GGACGGGAACGGGGCCATCCA	0.622000												
HOXD3	3232	broad.mit.edu	37	2	177036736	177036736	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr2:177036736G>A	uc002ukt.1	+	3	1209	c.1033G>A	c.(1033-1035)GGC>AGC	p.G345S		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	345					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		CAACGGCGGCGGCTTCGCCAG	0.697000												
TTN	7273	broad.mit.edu	37	2	179640792	179640792	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr2:179640792T>G	uc010zfg.1	-	28	6023	c.5799A>C	c.(5797-5799)GAA>GAC	p.E1933D	TTN_uc010zfh.1_Missense_Mutation_p.E1887D|TTN_uc010zfi.1_Missense_Mutation_p.E1887D|TTN_uc010zfj.1_Missense_Mutation_p.E1887D|TTN_uc002unb.2_Missense_Mutation_p.E1933D|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1933							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTAAAATCTTCCCTCTGTT	0.443000												
OBSL1	23363	broad.mit.edu	37	2	220432469	220432469	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr2:220432469G>A	uc010fwk.2	-	3	1562	c.1505C>T	c.(1504-1506)TCC>TTC	p.S502F	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Missense_Mutation_p.S502F|OBSL1_uc002vmj.2_Missense_Mutation_p.S89F	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	502					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		AGTGGTACGGGAGTTGCCCAG	0.622000												
SNPH	9751	broad.mit.edu	37	20	1277044	1277044	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr20:1277044G>C	uc002wes.2	+	3	265	c.29G>C	c.(28-30)CGG>CCG	p.R10P	SNPH_uc002wet.2_Missense_Mutation_p.R54P	NM_014723	NP_055538	O15079	SNPH_HUMAN	syntaphilin	10					synaptic vesicle docking involved in exocytosis	cell junction|integral to membrane|synapse|synaptosome	syntaxin-1 binding			ovary(2)	2						GGAAGTAGACGGACCTCTGCT	0.642000												
GGTLC1	92086	broad.mit.edu	37	20	23967072	23967072	+	Splice_Site	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr20:23967072C>T	uc002wts.2	-	2	309	c.176_splice	c.e2+1	p.Y59_splice	GGTLC1_uc002wtu.2_Splice_Site_p.Y59_splice	NM_178312	NP_842564	Q9BX51	GGTL1_HUMAN	gamma-glutamyltransferase light chain 1								gamma-glutamyltransferase activity			ovary(1)	1						GCAGCCCCTACTAGAGGTTGA	0.632000												
KRTAP21-2	337978	broad.mit.edu	37	21	32119459	32119459	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr21:32119459G>A	uc011adh.1	-	1	62	c.62C>T	c.(61-63)TCC>TTC	p.S21F		NM_181617	NP_853648	Q3LI59	KR212_HUMAN	keratin associated protein 21-2	21						intermediate filament					0						tccacagccggaactccagcc	0.149000												
OR5K1	26339	broad.mit.edu	37	3	98188977	98188977	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr3:98188977G>A	uc003dsm.2	+	1	557	c.557G>A	c.(556-558)AGA>AAA	p.R186K		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						CCCTTGTATAGACTCTCTTGT	0.363000												
DHX36	170506	broad.mit.edu	37	3	154010343	154010343	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr3:154010343C>T	uc003ezy.3	-	15	1892	c.1811G>A	c.(1810-1812)GGA>GAA	p.G604E	DHX36_uc010hvq.2_Missense_Mutation_p.G590E|DHX36_uc003ezz.3_Missense_Mutation_p.G604E	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	604	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			ACCTTACCTTCCAGCTCGACC	0.348000												
FNDC3B	64778	broad.mit.edu	37	3	172055153	172055153	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr3:172055153T>G	uc003fhy.2	+	16	1986	c.1814T>G	c.(1813-1815)CTC>CGC	p.L605R	FNDC3B_uc003fhz.3_Missense_Mutation_p.L605R|FNDC3B_uc003fia.2_Missense_Mutation_p.L536R	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	605	Fibronectin type-III 4.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TCAGAAATCCTCAAGTACTTG	0.328000												
WHSC1	7468	broad.mit.edu	37	4	1978261	1978261	+	Silent	SNP	G	G	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr4:1978261G>A	uc003gdz.3	+	21	3857	c.3681G>A	c.(3679-3681)CGG>CGA	p.R1227R	WHSC1_uc003geb.3_Silent_p.R1227R|WHSC1_uc003gec.3_Silent_p.R1227R|WHSC1_uc003ged.3_Silent_p.R1227R|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Silent_p.R446R|WHSC1_uc011bvh.1_Silent_p.R288R|WHSC1_uc010icf.2_Silent_p.R575R	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1227					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		AAACGAGGCGGCGCAGAGCAA	0.537000			T	IGH@	MM							
LATS1	9113	broad.mit.edu	37	6	150001244	150001244	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr6:150001244C>G	uc003qmu.1	-	5	2908	c.2360G>C	c.(2359-2361)GGG>GCG	p.G787A	LATS1_uc010kif.1_Missense_Mutation_p.G682A|LATS1_uc003qmv.1_Missense_Mutation_p.G787A	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	787	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		CATATCACCCCCAGGAATGTA	0.388000												
CHRM2	1129	broad.mit.edu	37	7	136701002	136701002	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr7:136701002G>A	uc003vtf.1	+	4	2013	c.1390G>A	c.(1390-1392)GCT>ACT	p.A464T	CHRM2_uc003vtg.1_Missense_Mutation_p.A464T|CHRM2_uc003vtj.1_Missense_Mutation_p.A464T|CHRM2_uc003vtk.1_Missense_Mutation_p.A464T|CHRM2_uc003vtl.1_Missense_Mutation_p.A464T|CHRM2_uc003vtm.1_Missense_Mutation_p.A464T|CHRM2_uc003vti.1_Missense_Mutation_p.A464T|CHRM2_uc003vto.1_Missense_Mutation_p.A464T|CHRM2_uc003vtn.1_Missense_Mutation_p.A464T|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	464	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GAACATAGGCGCTACAAGGTA	0.408000												
RP1L1	94137	broad.mit.edu	37	8	10467031	10467031	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr8:10467031G>A	uc003wtc.2	-	4	4806	c.4577C>T	c.(4576-4578)ACG>ATG	p.T1526M		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1526					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GGCCTTCTCCGTCTTCTTCAG	0.662000												
PSD3	23362	broad.mit.edu	37	8	18725257	18725257	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr8:18725257C>T	uc003wza.2	-	4	1664	c.1561G>A	c.(1561-1563)GTC>ATC	p.V521I		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	521					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		CCATTGGTGACGCCACTAGAA	0.522000												
UNC5D	137970	broad.mit.edu	37	8	35542177	35542177	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr8:35542177C>T	uc003xjr.1	+	6	1157	c.829C>T	c.(829-831)CGG>TGG	p.R277W	UNC5D_uc003xjs.1_Missense_Mutation_p.R272W|UNC5D_uc003xjt.1_Missense_Mutation_p.R46W	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	277	TSP type-1 1.|Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GAAACGTTCCCGGACCTGCAC	0.522000												
CSMD3	114788	broad.mit.edu	37	8	113960100	113960100	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr8:113960100T>A	uc003ynu.2	-	9	1586	c.1427A>T	c.(1426-1428)GAG>GTG	p.E476V	CSMD3_uc003ynt.2_Missense_Mutation_p.E436V|CSMD3_uc011lhx.1_Missense_Mutation_p.E372V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	476	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AATACCTCCCTCATTTACTGC	0.274000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
SEC16A	9919	broad.mit.edu	37	9	139368957	139368957	+	Silent	SNP	A	A	C			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chr9:139368957A>C	uc004chx.2	-	3	3420	c.3111T>G	c.(3109-3111)CTT>CTG	p.L1037L	SEC16A_uc004chv.3_Intron|SEC16A_uc004chw.2_Silent_p.L1037L|SEC16A_uc010nbn.2_Silent_p.L1037L|SEC16A_uc010nbo.1_Silent_p.L1037L	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	859					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		AAAAACGGTCAAGGTTAGGCG	0.582000												
PCDH11X	27328	broad.mit.edu	37	X	91134131	91134131	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chrX:91134131A>C	uc004efk.1	+	2	3737	c.2892A>C	c.(2890-2892)CAA>CAC	p.Q964H	PCDH11X_uc004efl.1_Missense_Mutation_p.Q964H|PCDH11X_uc004efo.1_Missense_Mutation_p.Q964H|PCDH11X_uc010nmv.1_Missense_Mutation_p.Q964H|PCDH11X_uc004efm.1_Missense_Mutation_p.Q964H|PCDH11X_uc004efn.1_Missense_Mutation_p.Q964H|PCDH11X_uc004efh.1_Missense_Mutation_p.Q964H|PCDH11X_uc004efj.1_Missense_Mutation_p.Q964H	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	964	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ACATCATCCAAGAACTGCCTC	0.507000												
NRK	203447	broad.mit.edu	37	X	105178264	105178264	+	Silent	SNP	A	A	G			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chrX:105178264A>G	uc004emd.2	+	20	3630	c.3327A>G	c.(3325-3327)GGA>GGG	p.G1109G	NRK_uc010npc.1_Silent_p.G777G	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1109							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						CAGGTGGTGGAAATGAGGCCT	0.418000										HNSCC(51;0.14)		
DCAF12L2	340578	broad.mit.edu	37	X	125299770	125299770	+	Silent	SNP	C	C	T			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chrX:125299770C>T	uc004euk.1	-	1	165	c.138G>A	c.(136-138)GCG>GCA	p.A46A		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	46										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						TGCGACGCGTCGCCGGCCGCT	0.741000												
MAGEC1	9947	broad.mit.edu	37	X	140995303	140995303	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8384-01A-21D-2394-08	TCGA-BR-8384-10A-01D-2394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	67e2a6ef-86ba-44b7-8e27-caa5d939abc9	f3204691-0a34-4064-90ce-8fa32a8e43c4	g.chrX:140995303C>A	uc004fbt.2	+	4	2399	c.2113C>A	c.(2113-2115)CTG>ATG	p.L705M	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	705							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGGACTCCCTGTCTTCTCT	0.562000										HNSCC(15;0.026)