Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PER3	8863	broad.mit.edu	37	1	7863904	7863904	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:7863904C>T	uc001aoo.2	+	9	1304	c.1129C>T	c.(1129-1131)CGA>TGA	p.R377*	PER3_uc009vmg.1_Nonsense_Mutation_p.R378*|PER3_uc009vmh.1_Nonsense_Mutation_p.R378*|PER3_uc001aop.2_Nonsense_Mutation_p.R378*|PER3_uc010nzw.1_Nonsense_Mutation_p.R59*|PER3_uc001aon.2_Nonsense_Mutation_p.R377*	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	377	PAC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		GCATAAAGTTCGAACGTAAGC	0.388000												
FBXO44	93611	broad.mit.edu	37	1	11715958	11715958	+	Silent	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:11715958C>T	uc001asm.2	+	2	192	c.66C>T	c.(64-66)CCC>CCT	p.P22P	FBXO2_uc001asj.2_5'Flank|FBXO2_uc009vna.2_5'Flank|FBXO2_uc009vnb.1_5'Flank|FBXO44_uc001ask.2_Silent_p.P22P|FBXO44_uc010oaq.1_Silent_p.P22P|FBXO44_uc001asl.2_Silent_p.P22P|FBXO44_uc001asn.2_Silent_p.P22P|FBXO44_uc010oar.1_Silent_p.P22P|FBXO44_uc010oas.1_Intron	NM_033182	NP_149438	Q9H4M3	FBX44_HUMAN	F-box protein 44 isoform 1	22	F-box.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CGCACGTGCCCGCCCGCCAGC	0.632000												
BRDT	676	broad.mit.edu	37	1	92433710	92433710	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:92433710A>T	uc001dok.3	+	4	687	c.338A>T	c.(337-339)GAT>GTT	p.D113V	BRDT_uc001dol.3_Missense_Mutation_p.D113V|BRDT_uc010osz.1_Missense_Mutation_p.D113V|BRDT_uc009wdf.2_Missense_Mutation_p.D40V|BRDT_uc010ota.1_Missense_Mutation_p.D67V|BRDT_uc010otb.1_Missense_Mutation_p.D67V|BRDT_uc001dom.3_Missense_Mutation_p.D113V	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	113	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		TAGCCTGGAGATGACATTGTT	0.368000												
CD1A	909	broad.mit.edu	37	1	158226001	158226001	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:158226001T>C	uc001frt.2	+	3	1066	c.533T>C	c.(532-534)CTT>CCT	p.L178P		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	178	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	ACACACAATCTTCTCAGTGAC	0.473000												
DCAF6	55827	broad.mit.edu	37	1	167974018	167974018	+	Silent	SNP	A	A	G			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:167974018A>G	uc001gew.2	+	10	1607	c.1365A>G	c.(1363-1365)ACA>ACG	p.T455T	DCAF6_uc001gev.2_Silent_p.T455T|DCAF6_uc001gex.2_Silent_p.T455T|DCAF6_uc010plk.1_Silent_p.T424T|DCAF6_uc001gey.2_Silent_p.T308T	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	455					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GACACCACACACATCATCAGT	0.398000												
SELP	6403	broad.mit.edu	37	1	169565209	169565209	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:169565209G>C	uc001ggi.3	-	12	2120	c.2055C>G	c.(2053-2055)AGC>AGG	p.S685R	SELP_uc001ggh.2_Missense_Mutation_p.S520R|SELP_uc009wvr.2_Missense_Mutation_p.S685R	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	685	Extracellular (Potential).|Sushi 8.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	AAGGTCTGCAGCTGAGAGTGC	0.493000												
PAPPA2	60676	broad.mit.edu	37	1	176668366	176668366	+	Silent	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:176668366C>T	uc001gkz.2	+	8	4041	c.2877C>T	c.(2875-2877)CAC>CAT	p.H959H	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	959					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TCTTCCAACACCCGGTCCAAG	0.567000												
PAPPA2	60676	broad.mit.edu	37	1	176668713	176668713	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:176668713A>C	uc001gkz.2	+	8	4388	c.3224A>C	c.(3223-3225)AAG>ACG	p.K1075T	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1075					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TCTCACAGGAAGTTCACGGAC	0.537000												
FAM71A	149647	broad.mit.edu	37	1	212798427	212798427	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:212798427A>T	uc001hjk.2	+	1	612	c.208A>T	c.(208-210)ACC>TCC	p.T70S	uc010pth.1_Intron	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	70										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CCGTATGGTGACCATGGGCAT	0.527000												
RYR2	6262	broad.mit.edu	37	1	237870335	237870335	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:237870335G>A	uc001hyl.1	+	68	9787	c.9667G>A	c.(9667-9669)GAG>AAG	p.E3223K	RYR2_uc010pxz.1_Missense_Mutation_p.E178K	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3223					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGAATTAGCCGAGTCCGGCAT	0.468000												
OR2L2	26246	broad.mit.edu	37	1	248201664	248201664	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr1:248201664T>C	uc001idw.2	+	1	191	c.95T>C	c.(94-96)CTC>CCC	p.L32P	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTCATTTTTCTCATTTTCCTA	0.378000												
GATA3	2625	broad.mit.edu	37	10	8100641	8100641	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr10:8100641G>A	uc001ika.2	+	3	1172	c.615G>A	c.(613-615)ATG>ATA	p.M205I	GATA3_uc001ijz.2_Missense_Mutation_p.M205I	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	205					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						GTGGCAGCATGACCGCCCTGG	0.687000			F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)					
CELF2	10659	broad.mit.edu	37	10	11259399	11259399	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr10:11259399G>A	uc001iki.3	+	3	354	c.262G>A	c.(262-264)GTA>ATA	p.V88I	CELF2_uc010qbi.1_Intron|CELF2_uc010qbj.1_Missense_Mutation_p.V88I|CELF2_uc001ikk.2_Missense_Mutation_p.V95I|CELF2_uc001ikl.3_Missense_Mutation_p.V95I|CELF2_uc010qbk.1_RNA|CELF2_uc010qbl.1_Missense_Mutation_p.V64I|CELF2_uc010qbm.1_Intron|CELF2_uc001iko.3_Missense_Mutation_p.V64I|CELF2_uc001ikp.3_Missense_Mutation_p.V64I|CELF2_uc010qbn.1_Missense_Mutation_p.V72I|CELF2_uc009xiw.1_Intron|CELF2_uc010qbo.1_Intron|CELF2_uc010qbp.1_Intron	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	88	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 1.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						TTGTTGTTTCGTAACATTTTA	0.368000												
FRMPD2	143162	broad.mit.edu	37	10	49376666	49376666	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr10:49376666G>A	uc001jgi.2	-	27	3616	c.3509C>T	c.(3508-3510)GCG>GTG	p.A1170V	FRMPD2_uc001jgh.2_Missense_Mutation_p.A1138V|FRMPD2_uc001jgj.2_Missense_Mutation_p.A1148V|FRMPD2L1_uc001jgf.2_Missense_Mutation_p.A181V|FRMPD2_uc001jgg.2_Missense_Mutation_p.A122V|FRMPD2_uc001jgk.2_Missense_Mutation_p.A122V	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	1170					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CTCAGGCAGCGCACCTGGAGG	0.572000												
OR5T2	219464	broad.mit.edu	37	11	55999758	55999758	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr11:55999758T>G	uc010rjc.1	-	1	904	c.904A>C	c.(904-906)AGT>CGT	p.S302R		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	302	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TAGCTGGAACTTGGTCTCACA	0.428000												
OR9G4	283189	broad.mit.edu	37	11	56510973	56510973	+	Silent	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr11:56510973C>T	uc010rjo.1	-	1	315	c.315G>A	c.(313-315)AAG>AAA	p.K105K		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	105	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						AGGAAATGCGCTTATCTTCTG	0.463000												
MMP27	64066	broad.mit.edu	37	11	102563733	102563733	+	Silent	SNP	C	C	T	rs138562543	by1000genomes	TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr11:102563733C>T	uc001phd.1	-	9	1256	c.1233G>A	c.(1231-1233)CCG>CCA	p.P411P		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	411	Hemopexin-like 3.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		CCACTCTCTGCGGGAACCCTT	0.433000												
FGF23	8074	broad.mit.edu	37	12	4479725	4479725	+	Silent	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr12:4479725G>A	uc001qmq.1	-	3	686	c.540C>T	c.(538-540)AGC>AGT	p.S180S		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	180		Cleavage; by proprotein convertases.			cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			CGTCCTCGGCGCTCCGGGTGT	0.687000												
TRPV4	59341	broad.mit.edu	37	12	110230484	110230484	+	Silent	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr12:110230484C>T	uc001tpj.1	-	10	1892	c.1797G>A	c.(1795-1797)ACG>ACA	p.T599T	TRPV4_uc001tpg.1_Silent_p.T565T|TRPV4_uc001tph.1_Silent_p.T552T|TRPV4_uc001tpi.1_Silent_p.T492T|TRPV4_uc001tpk.1_Silent_p.T599T|TRPV4_uc001tpl.1_Silent_p.T539T	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	599	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TATAGGTCCCCGTCAGCTTCA	0.577000												
RCBTB1	55213	broad.mit.edu	37	13	50140787	50140787	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr13:50140787C>T	uc001vde.1	-	4	505	c.244G>A	c.(244-246)GGG>AGG	p.G82R		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and	82	RCC1 1.				cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		GGTCCACTCCCGTAACTGAGG	0.423000												
TBPL2	387332	broad.mit.edu	37	14	55907216	55907216	+	Silent	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr14:55907216C>T	uc001xby.2	-	1	48	c.48G>A	c.(46-48)CCG>CCA	p.P16P		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	16					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						AGGGTAAGCGCGGAGCGAGCA	0.692000												
HSPA2	3306	broad.mit.edu	37	14	65008905	65008905	+	Silent	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr14:65008905C>T	uc001xhj.2	+	2	1414	c.1338C>T	c.(1336-1338)TAC>TAT	p.Y446Y	HSPA2_uc001xhk.3_Silent_p.Y446Y	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	446					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		TGCAGGTATACGAGGGCGAAC	0.597000												
TSHR	7253	broad.mit.edu	37	14	81609934	81609934	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr14:81609934C>T	uc001xvd.1	+	10	1688	c.1532C>T	c.(1531-1533)ACG>ATG	p.T511M		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	511	Helical; Name=3; (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TCGGTGTATACGCTGACGGTC	0.577000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 					
RAGE	5891	broad.mit.edu	37	14	102700063	102700063	+	Silent	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr14:102700063G>A	uc001ylm.2	-	8	880	c.654C>T	c.(652-654)ATC>ATT	p.I218I	RAGE_uc010txv.1_Silent_p.I188I|RAGE_uc001yln.2_Silent_p.I36I|RAGE_uc001ylh.2_RNA|RAGE_uc001yli.2_RNA|RAGE_uc001yll.2_RNA|RAGE_uc001ylj.2_RNA|RAGE_uc001ylk.2_RNA	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	218	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CGGGTGTGCCGATGACATCGT	0.527000												
TLN2	83660	broad.mit.edu	37	15	63111822	63111822	+	Splice_Site	SNP	T	T	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr15:63111822T>A	uc002alb.3	+	50	6877	c.6877_splice	c.e50+2	p.G2293_splice	TLN2_uc002alc.3_Splice_Site_p.G686_splice|TLN2_uc010uic.1_5'Flank	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2						cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CCATGAAAGGTAGGCTGGATT	0.572000												
NOX5	79400	broad.mit.edu	37	15	69328256	69328256	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr15:69328256C>T	uc002ars.1	+	7	1188	c.1168C>T	c.(1168-1170)CGC>TGC	p.R390C	NOX5_uc002arp.1_Missense_Mutation_p.R372C|NOX5_uc002arq.1_Missense_Mutation_p.R344C|NOX5_uc010bid.1_Missense_Mutation_p.R355C|NOX5_uc002arr.1_Missense_Mutation_p.R362C|NOX5_uc010bie.1_Missense_Mutation_p.R190C|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	390	Ferric oxidoreductase.|Cytoplasmic (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						TTCCTGCATCCGCAGGAGTGG	0.582000												
NEO1	4756	broad.mit.edu	37	15	73552659	73552659	+	Missense_Mutation	SNP	G	G	A	rs140293397		TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr15:73552659G>A	uc002avm.3	+	15	2393	c.2251G>A	c.(2251-2253)GTT>ATT	p.V751I	NEO1_uc010ukx.1_Missense_Mutation_p.V751I|NEO1_uc010uky.1_Missense_Mutation_p.V751I|NEO1_uc010ukz.1_Missense_Mutation_p.V175I|NEO1_uc002avn.3_Missense_Mutation_p.V416I	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	751	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						ACGCCCGCTCGTTACTAGCAT	0.483000												
ALPK3	57538	broad.mit.edu	37	15	85383832	85383832	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr15:85383832C>T	uc002ble.2	+	5	2095	c.1928C>T	c.(1927-1929)GCG>GTG	p.A643V		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	643					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGTGTCCGGGCGCCTGGGGAG	0.652000												
TTLL13	440307	broad.mit.edu	37	15	90799041	90799041	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr15:90799041C>T	uc002bpd.1	+	5	760	c.472C>T	c.(472-474)CGG>TGG	p.R158W	TTLL13_uc002bpe.1_Intron	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	158	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			TCTGCTGGCTCGGAACCTCAA	0.532000												
E4F1	1877	broad.mit.edu	37	16	2285333	2285333	+	Silent	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr16:2285333G>A	uc002cpm.2	+	14	2163	c.2115G>A	c.(2113-2115)GCG>GCA	p.A705A	E4F1_uc010bsi.2_3'UTR|E4F1_uc010bsj.2_Silent_p.A528A|DNASE1L2_uc002cpn.2_5'Flank|DNASE1L2_uc002cpo.2_5'Flank|DNASE1L2_uc002cpp.2_5'Flank|DNASE1L2_uc002cpq.2_5'Flank	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	705				EA -> RG (in Ref. 1; AAD09139).	cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GCCCAGAGGCGGCTGCCGCCG	0.672000												
SRRM2	23524	broad.mit.edu	37	16	2815007	2815007	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr16:2815007C>G	uc002crk.2	+	11	5027	c.4478C>G	c.(4477-4479)CCT>CGT	p.P1493R	SRRM2_uc002crj.1_Missense_Mutation_p.P1397R|SRRM2_uc002crl.1_Missense_Mutation_p.P1493R|SRRM2_uc010bsu.1_Missense_Mutation_p.P1397R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1493	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCTCAGACTCCTAGGCCGAGG	0.498000												
ABCC6	368	broad.mit.edu	37	16	16256896	16256896	+	Missense_Mutation	SNP	C	C	T	rs147794514		TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr16:16256896C>T	uc002den.3	-	24	3497	c.3460G>A	c.(3460-3462)GTA>ATA	p.V1154I	ABCC6_uc010bvo.2_Intron	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	1154	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CTTTCATCTACGCGAGCATTG	0.572000												
TPPP3	51673	broad.mit.edu	37	16	67424237	67424237	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr16:67424237C>T	uc002esz.2	-	3	1206	c.371G>A	c.(370-372)CGG>CAG	p.R124Q	TPPP3_uc002eta.2_Missense_Mutation_p.R124Q|TPPP3_uc002etb.2_Missense_Mutation_p.R124Q	NM_016140	NP_057224	Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family	124					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		GTCCGTCAGCCGGTCTACAGC	0.617000												
SMG6	23293	broad.mit.edu	37	17	2203683	2203683	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr17:2203683G>A	uc002fub.1	-	2	419	c.364C>T	c.(364-366)CCT>TCT	p.P122S	SMG6_uc002fud.1_Missense_Mutation_p.P91S	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	122	Interaction with telomeric DNA.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						GCAGTCCTAGGAAAGGATTCT	0.443000												
MINK1	50488	broad.mit.edu	37	17	4794768	4794768	+	Silent	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr17:4794768G>A	uc010vsl.1	+	16	1954	c.1758G>A	c.(1756-1758)CGG>CGA	p.R586R	MINK1_uc010vsk.1_Silent_p.R586R|MINK1_uc010vsm.1_Intron|MINK1_uc010vsn.1_Silent_p.R586R|MINK1_uc010vso.1_Silent_p.R531R|MINK1_uc010vsp.1_Silent_p.R76R	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	586					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						TGGCACACCGGGTCCCACTGA	0.657000												
IMP5	162540	broad.mit.edu	37	17	43922979	43922979	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr17:43922979C>A	uc010wka.1	+	1	707	c.707C>A	c.(706-708)GCT>GAT	p.A236D	LOC100128977_uc010wjz.1_Intron	NM_175882	NP_787078	Q8IUH8	IMP5_HUMAN	intramembrane protease 5 precursor	236	Cytoplasmic (Potential).					integral to membrane	aspartic-type endopeptidase activity			pancreas(2)	2	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.148)		GCTGCAGCAGCTGAGGGAGCC	0.642000												
LRRC37A3	374819	broad.mit.edu	37	17	62857004	62857004	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr17:62857004A>G	uc002jey.2	-	11	3791	c.3260T>C	c.(3259-3261)ATT>ACT	p.I1087T	LRRC37A3_uc010wqg.1_Missense_Mutation_p.I205T|LRRC37A3_uc002jex.1_Missense_Mutation_p.I64T|LRRC37A3_uc010wqf.1_Missense_Mutation_p.I125T|LRRC37A3_uc010dek.1_Missense_Mutation_p.I93T	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1087	Extracellular (Potential).					integral to membrane					0						CTCCGGCTCAATAATCAGCTC	0.483000												
SEPT9	10801	broad.mit.edu	37	17	75398336	75398336	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr17:75398336G>A	uc002jts.3	+	3	398	c.272G>A	c.(271-273)CGG>CAG	p.R91Q	SEPT9_uc010wtk.1_Missense_Mutation_p.R72Q|SEPT9_uc002jtt.3_5'UTR|SEPT9_uc002jtu.3_Missense_Mutation_p.R73Q|SEPT9_uc002jtv.2_Missense_Mutation_p.R84Q|SEPT9_uc002jtw.2_5'UTR|SEPT9_uc002jtx.1_5'UTR|SEPT9_uc010wtl.1_5'Flank	NM_001113491	NP_001106963	Q9UHD8	SEPT9_HUMAN	septin 9 isoform a	91					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding|protein binding			breast(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(99;0.153)			GCGTCCCTGCGGAGGGTGGAG	0.667000												
OR7D2	162998	broad.mit.edu	37	19	9297018	9297018	+	Silent	SNP	G	G	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:9297018G>T	uc002mkz.1	+	1	749	c.561G>T	c.(559-561)CTG>CTT	p.L187L		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	187	Extracellular (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						TCCTCCAGCTGGCCTGCTCTG	0.433000												
GIPC1	10755	broad.mit.edu	37	19	14591450	14591450	+	Silent	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:14591450G>A	uc002myt.2	-	5	699	c.429C>T	c.(427-429)CTC>CTT	p.L143L	GIPC1_uc002myu.2_Silent_p.L143L|GIPC1_uc002myv.2_Silent_p.L46L|GIPC1_uc002myw.2_Silent_p.L46L|GIPC1_uc002myx.2_Silent_p.L143L|GIPC1_uc002myy.2_Silent_p.L46L	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	143	PDZ.				endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						TGGTGAGCCCGAGTGCATCCT	0.657000											OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
NCAN	1463	broad.mit.edu	37	19	19329874	19329874	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:19329874G>A	uc002nlz.2	+	3	323	c.224G>A	c.(223-225)CGG>CAG	p.R75Q		NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	75	Ig-like V-type.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GATGCCCCTCGGATAAAGTGG	0.657000												
ZNF14	7561	broad.mit.edu	37	19	19824904	19824904	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:19824904G>A	uc002nnk.1	-	3	341	c.187C>T	c.(187-189)CGA>TGA	p.R63*		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				ACTCACCTTCGATTTTTCCCC	0.368000												
ZNF676	163223	broad.mit.edu	37	19	22363376	22363376	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:22363376A>C	uc002nqs.1	-	3	1461	c.1143T>G	c.(1141-1143)AAT>AAG	p.N381K		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	381	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CCTTATGTGTATTAAGGGTTG	0.393000												
FCGBP	8857	broad.mit.edu	37	19	40366308	40366308	+	Silent	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:40366308G>A	uc002omp.3	-	30	13934	c.13926C>T	c.(13924-13926)TGC>TGT	p.C4642C		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4642	VWFD 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CACATTCCCCGCAGCCCTGGG	0.697000												
CBLC	23624	broad.mit.edu	37	19	45296762	45296762	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:45296762G>A	uc002ozs.2	+	8	1232	c.1169G>A	c.(1168-1170)CGC>CAC	p.R390H	CBLC_uc010ejt.2_Missense_Mutation_p.R344H	NM_012116	NP_036248	Q9ULV8	CBLC_HUMAN	Cas-Br-M (murine) ecotropic retroviral	390	RING-type.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(1)|skin(1)	6	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				CCCTTCTGCCGCTGCGAGATC	0.637000			M		AML							
POLD1	5424	broad.mit.edu	37	19	50912857	50912857	+	Silent	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:50912857C>T	uc002psb.3	+	17	2144	c.2088C>T	c.(2086-2088)AGC>AGT	p.S696S	POLD1_uc002psc.3_Silent_p.S696S|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Silent_p.S722S	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	696					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		TGAAGGTGAGCGCCAACTCCG	0.682000								DNA_polymerases_(catalytic_subunits)				
ZNF548	147694	broad.mit.edu	37	19	57909885	57909885	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr19:57909885G>A	uc002qom.2	+	3	480	c.230G>A	c.(229-231)TGT>TAT	p.C77Y	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.C80Y	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCAAAGCCCTGTCTGTCCAGC	0.512000												
APOB	338	broad.mit.edu	37	2	21227217	21227217	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr2:21227217G>T	uc002red.2	-	28	12139	c.12011C>A	c.(12010-12012)CCA>CAA	p.P4004Q		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4004					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCCTACGGCTGGGGAGGCTGC	0.498000												
APOB	338	broad.mit.edu	37	2	21227262	21227262	+	Missense_Mutation	SNP	C	C	T	rs148197354		TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr2:21227262C>T	uc002red.2	-	28	12094	c.11966G>A	c.(11965-11967)CGC>CAC	p.R3989H		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3989					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTCTGGTAGCGCAGATGGAG	0.507000												
TBC1D8	11138	broad.mit.edu	37	2	101646088	101646088	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr2:101646088G>A	uc010fiv.2	-	12	2173	c.2042C>T	c.(2041-2043)GCG>GTG	p.A681V	TBC1D8_uc002tau.3_Missense_Mutation_p.A438V	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	681	Rab-GAP TBC.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CACATTCACCGCACTCTCTAG	0.567000												
IL1R2	7850	broad.mit.edu	37	2	102644697	102644697	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr2:102644697C>T	uc002tbm.2	+	9	1269	c.1040C>T	c.(1039-1041)ACG>ATG	p.T347M	IL1R2_uc002tbn.2_Missense_Mutation_p.T347M	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	347	Ig-like C2-type 3.|Helical; (Potential).				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	GCCTCCTCCACGTTCTCCTGG	0.507000												
HOXD10	3236	broad.mit.edu	37	2	176981985	176981985	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr2:176981985G>A	uc002ukj.2	+	1	494	c.424G>A	c.(424-426)GAG>AAG	p.E142K		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	142						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		TTGTCCCGTTGAGAACCCTGA	0.522000												
PDE1A	5136	broad.mit.edu	37	2	183104879	183104879	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr2:183104879C>T	uc002uos.2	-	4	440	c.356G>A	c.(355-357)CGG>CAG	p.R119Q	PDE1A_uc010zfp.1_Missense_Mutation_p.R15Q|PDE1A_uc002uoq.1_Missense_Mutation_p.R119Q|PDE1A_uc010zfq.1_Missense_Mutation_p.R119Q|PDE1A_uc002uor.2_Missense_Mutation_p.R103Q|PDE1A_uc002uou.2_Missense_Mutation_p.R85Q	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	119					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			CACAATGCTCCGAAATTTTGG	0.418000												
SPAG16	79582	broad.mit.edu	37	2	215013968	215013968	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr2:215013968T>G	uc002veq.2	+	15	1790	c.1698T>G	c.(1696-1698)AAT>AAG	p.N566K	SPAG16_uc010fuz.1_Missense_Mutation_p.N417K|SPAG16_uc002ver.2_Missense_Mutation_p.N512K|SPAG16_uc010zjk.1_Missense_Mutation_p.N472K	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	566	WD 6.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		GTCCTGGCAATGAGGTGAATT	0.388000												
ZCCHC3	85364	broad.mit.edu	37	20	279293	279293	+	Silent	SNP	A	A	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr20:279293A>C	uc002wdf.2	+	2	1087	c.1063A>C	c.(1063-1065)AGG>CGG	p.R355R	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	356	CCHC-type 2.						nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			CAGGTGCTTCAGGTGCGGGGA	0.622000												
C20orf195	79025	broad.mit.edu	37	20	62187885	62187885	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr20:62187885C>T	uc002yfj.2	+	2	961	c.869C>T	c.(868-870)ACG>ATG	p.T290M	C20orf195_uc002yfk.2_Missense_Mutation_p.T290M	NM_024059	NP_076964	Q9BVV2	CT195_HUMAN	hypothetical protein LOC79025	290											0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GAGACCTCCACGCTGGTGTAC	0.627000												
GAB4	128954	broad.mit.edu	37	22	17472781	17472781	+	Silent	SNP	T	T	G			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr22:17472781T>G	uc002zlw.2	-	2	568	c.460A>C	c.(460-462)AGG>CGG	p.R154R	GAB4_uc010gqs.1_Silent_p.R154R	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	154										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TCCTCCTGCCTGAAGCCACAG	0.562000												
WNT7B	7477	broad.mit.edu	37	22	46318808	46318808	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr22:46318808G>T	uc003bgo.2	-	4	1352	c.978C>A	c.(976-978)TGC>TGA	p.C326*	WNT7B_uc010haa.2_Nonsense_Mutation_p.C330*	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	326					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		AGTGGAATTTGCAGTTGCACT	0.652000												
CLCN2	1181	broad.mit.edu	37	3	184073278	184073278	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr3:184073278G>A	uc003foi.2	-	12	1334	c.1210C>T	c.(1210-1212)CGG>TGG	p.R404W	CLCN2_uc003foh.2_5'UTR|CLCN2_uc010hya.1_Missense_Mutation_p.R404W|CLCN2_uc011brl.1_Missense_Mutation_p.R404W|CLCN2_uc011brm.1_Missense_Mutation_p.R360W|CLCN2_uc011brn.1_Missense_Mutation_p.R404W	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	404						chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	ACCCACGTCCGATTGTCAAAC	0.602000												
KIAA1530	57654	broad.mit.edu	37	4	1374737	1374737	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr4:1374737C>T	uc003gde.3	+	12	2269	c.1822C>T	c.(1822-1824)CGT>TGT	p.R608C	KIAA1530_uc010ibv.2_Missense_Mutation_p.R159C	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	608											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			AGACAGGGCTCGTGAGCAGCG	0.667000												
WDR19	57728	broad.mit.edu	37	4	39254766	39254766	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr4:39254766A>C	uc003gtv.2	+	25	2884	c.2730A>C	c.(2728-2730)AGA>AGC	p.R910S	WDR19_uc011byi.1_Missense_Mutation_p.R750S|WDR19_uc003gtw.1_Missense_Mutation_p.R507S	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	910	TPR 4.				cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TTTTTTACAGATACAAAGAAG	0.318000												
TACR3	6870	broad.mit.edu	37	4	104640591	104640591	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr4:104640591G>A	uc003hxe.1	-	1	385	c.242C>T	c.(241-243)CCG>CTG	p.P81L		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	81	Extracellular (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GCGCCAGGACGGCTGCACGAA	0.647000												
FBXW7	55294	broad.mit.edu	37	4	153247366	153247366	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr4:153247366C>T	uc003ims.2	-	10	1585	c.1436G>A	c.(1435-1437)CGA>CAA	p.R479Q	FBXW7_uc011cii.1_Missense_Mutation_p.R479Q|FBXW7_uc003imt.2_Missense_Mutation_p.R479Q|FBXW7_uc011cih.1_Missense_Mutation_p.R303Q|FBXW7_uc003imq.2_Missense_Mutation_p.R399Q|FBXW7_uc003imr.2_Missense_Mutation_p.R361Q	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	479	WD 3.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R479Q(31)|p.R479L(7)|p.R479G(3)|p.R399Q(2)|p.R240L(1)|p.R399L(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403000			Mis|N|D|F		colorectal|endometrial|T-ALL							
DNAH5	1767	broad.mit.edu	37	5	13769145	13769145	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr5:13769145G>C	uc003jfd.2	-	58	9863	c.9821C>G	c.(9820-9822)TCT>TGT	p.S3274C	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3274	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTTGTCTTTAGAGATGCTGTC	0.458000									Kartagener_syndrome			
DDX4	54514	broad.mit.edu	37	5	55094378	55094378	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr5:55094378G>A	uc003jqg.3	+	18	1668	c.1594G>A	c.(1594-1596)GTT>ATT	p.V532I	DDX4_uc010ivz.2_Missense_Mutation_p.V512I|DDX4_uc003jqh.3_Missense_Mutation_p.V498I|DDX4_uc003jqj.2_Missense_Mutation_p.V383I	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	532	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				AGAAAAGCTCGTTGAAATTCT	0.328000												
HTR1A	3350	broad.mit.edu	37	5	63256939	63256939	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr5:63256939G>T	uc011cqt.1	-	1	608	c.608C>A	c.(607-609)GCT>GAT	p.A203D		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	203	Helical; Name=5; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	GATGTAGAAAGCTCCAAAGGT	0.587000												
CTNNA1	1495	broad.mit.edu	37	5	138221962	138221962	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr5:138221962C>T	uc003ldh.2	+	8	1219	c.1124C>T	c.(1123-1125)ACC>ATC	p.T375I	CTNNA1_uc011cyx.1_Missense_Mutation_p.T272I|CTNNA1_uc011cyy.1_Missense_Mutation_p.T252I|CTNNA1_uc003ldi.2_Missense_Mutation_p.T73I|CTNNA1_uc003ldj.2_Missense_Mutation_p.T375I|CTNNA1_uc003ldl.2_Missense_Mutation_p.T5I	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	375	Interaction with alpha-actinin.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACCAAGAAGACCAGGGACTTG	0.358000												
HCRTR2	3062	broad.mit.edu	37	6	55145214	55145214	+	Silent	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr6:55145214G>A	uc003pcl.2	+	6	1392	c.1077G>A	c.(1075-1077)GCG>GCA	p.A359A	HCRTR2_uc010jzv.2_RNA	NM_001526	NP_001517	O43614	OX2R_HUMAN	orexin receptor 2	359	Helical; Name=7; (Potential).				feeding behavior	integral to plasma membrane	neuropeptide receptor activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|breast(1)	6	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATAGTGCTGCGAATCCAATTA	0.343000												
HOXA1	3198	broad.mit.edu	37	7	27135441	27135441	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr7:27135441C>T	uc003sye.2	-	1	185	c.91G>A	c.(91-93)GAC>AAC	p.D31N	HOXA1_uc003syd.2_Missense_Mutation_p.D31N|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	31						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						ATCCTATGGTCCGAGGGGTAG	0.597000											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay
HECW1	23072	broad.mit.edu	37	7	43484720	43484720	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr7:43484720C>T	uc003tid.1	+	11	2554	c.1949C>T	c.(1948-1950)ACG>ATG	p.T650M	HECW1_uc011kbi.1_Missense_Mutation_p.T650M	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	650					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GATGGCGACACGCACCCCAGC	0.716000												
HEPACAM2	253012	broad.mit.edu	37	7	92855746	92855746	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr7:92855746G>C	uc003umm.2	-	1	37	c.14C>G	c.(13-15)GCT>GGT	p.A5G	HEPACAM2_uc011khy.1_Missense_Mutation_p.A5G	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	5						integral to membrane				ovary(3)|breast(1)|kidney(1)	5						CTCCATGAAAGCATCCTGTCC	0.488000												
SVOPL	136306	broad.mit.edu	37	7	138329520	138329520	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr7:138329520C>T	uc011kqh.1	-	8	731	c.731G>A	c.(730-732)CGC>CAC	p.R244H	SVOPL_uc003vue.2_Missense_Mutation_p.R92H	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	244						integral to membrane	transmembrane transporter activity				0						CTTGGCAACGCGCTCCAGAGT	0.587000												
SMARCD3	6604	broad.mit.edu	37	7	150936233	150936233	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr7:150936233G>A	uc003wjs.2	-	13	1509	c.1408C>T	c.(1408-1410)CGC>TGC	p.R470C	SMARCD3_uc003wjt.2_Missense_Mutation_p.R457C|SMARCD3_uc003wju.2_Missense_Mutation_p.R457C	NM_001003801	NP_001003801	Q6STE5	SMRD3_HUMAN	SWI/SNF related, matrix associated, actin	470					cellular lipid metabolic process|chromatin modification|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	nuclear hormone receptor binding|protein binding|transcription coactivator activity|transcription factor binding			ovary(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCCTGCCTGCGCTGCTGGATC	0.572000												
ELAVL2	1993	broad.mit.edu	37	9	23762098	23762098	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr9:23762098G>C	uc003zpu.2	-	2	410	c.135C>G	c.(133-135)TAC>TAG	p.Y45*	ELAVL2_uc003zps.2_Nonsense_Mutation_p.Y45*|ELAVL2_uc003zpt.2_Nonsense_Mutation_p.Y45*|ELAVL2_uc003zpv.2_Nonsense_Mutation_p.Y45*|ELAVL2_uc003zpw.2_Nonsense_Mutation_p.Y45*	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	45	RRM 1.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TCTGAGGAAGGTAGTTGACTA	0.428000												
ELAVL2	1993	broad.mit.edu	37	9	23762120	23762120	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr9:23762120T>G	uc003zpu.2	-	2	388	c.113A>C	c.(112-114)AAG>ACG	p.K38T	ELAVL2_uc003zps.2_Missense_Mutation_p.K38T|ELAVL2_uc003zpt.2_Missense_Mutation_p.K38T|ELAVL2_uc003zpv.2_Missense_Mutation_p.K38T|ELAVL2_uc003zpw.2_Missense_Mutation_p.K38T	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	38					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TAAGTTGGTCTTGCTGTCTTC	0.443000												
FBXO10	26267	broad.mit.edu	37	9	37521626	37521626	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr9:37521626G>T	uc004aab.2	-	8	2189	c.2140C>A	c.(2140-2142)CCA>ACA	p.P714T	FBXO10_uc004aac.2_Missense_Mutation_p.P730T|FBXO10_uc004aad.2_Missense_Mutation_p.P264T	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	714						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		CGGCGCAGTGGGTCGTCCTCC	0.562000												
TTC16	158248	broad.mit.edu	37	9	130489637	130489637	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr9:130489637G>A	uc004brq.1	+	12	1724	c.1657G>A	c.(1657-1659)GAG>AAG	p.E553K	PTRH1_uc011mah.1_5'Flank|TTC16_uc011mai.1_Missense_Mutation_p.E540K|TTC16_uc004brr.1_Missense_Mutation_p.E403K|TTC16_uc010mxn.1_Missense_Mutation_p.E149K	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	553							binding				0						TGCGACCTCCGAGGAGCTGAA	0.517000												
ST6GALNAC4	27090	broad.mit.edu	37	9	130674788	130674788	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr9:130674788C>T	uc004bss.2	-	4	646	c.370G>A	c.(370-372)GTC>ATC	p.V124I	ST6GALNAC4_uc004bst.2_Missense_Mutation_p.V40I	NM_175039	NP_778204	Q9H4F1	SIA7D_HUMAN	sialyltransferase 7D isoform a	124	Lumenal (Potential).				glycolipid metabolic process|protein glycosylation	integral to Golgi membrane|nucleus|soluble fraction	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity				0						GTGTGTGAGACGACACGCAGG	0.632000												
FIGF	2277	broad.mit.edu	37	X	15402056	15402056	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chrX:15402056A>T	uc004cwt.1	-	1	522	c.13T>A	c.(13-15)TGG>AGG	p.W5R		NM_004469	NP_004460	O43915	VEGFD_HUMAN	vascular endothelial growth factor D	5					angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					ACCACTACCCACTCTCTGTAC	0.408000												
DCAF12L1	139170	broad.mit.edu	37	X	125685743	125685743	+	Silent	SNP	G	G	A			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chrX:125685743G>A	uc004eul.2	-	1	1100	c.849C>T	c.(847-849)GAC>GAT	p.D283D		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	283	WD 3.									skin(3)|ovary(1)	4						GGAAGTAGCCGTCCAAGGACA	0.622000												
SOX9	6662	broad.mit.edu	37	17	70119089	70119090	+	Frame_Shift_Ins	INS	-	-	GT			TCGA-BR-8380-01A-11D-2340-08	TCGA-BR-8380-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ccfe725-1cd6-41cc-9bd1-7b055fd04e20	1e4e8e97-c2ad-46a8-a939-f10d2b189716	g.chr17:70119088_70119089G>GGT	uc002jiw.3	+	1	1032_1033	c.660_661G>GGT	c.(658-663)gaggtgfs	p.E220fs	AK094963_uc002jiv.3_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	Homo sapiens SRY (sex determining region Y)-box 9 (SOX9), mRNA.	220					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			GCATGAGCGAGGTGCACTCCCC	0.698