Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
SPAG17	200162	broad.mit.edu	37	1	118550748	118550748	+	Silent	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr1:118550748G>A	uc001ehk.2	-	31	4574	c.4506C>T	c.(4504-4506)ATC>ATT	p.I1502I		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1502						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CACAGTTGGCGATAACAGTGG	0.502000												
CFH	3075	broad.mit.edu	37	1	196696029	196696029	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr1:196696029C>T	uc001gtj.3	+	14	2435	c.2195C>T	c.(2194-2196)ACG>ATG	p.T732M		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	732	Sushi 12.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						AGATCAATTACGTGTATTCAT	0.383000												
DENND5A	23258	broad.mit.edu	37	11	9199806	9199806	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr11:9199806A>T	uc001mhl.2	-	8	2034	c.1779T>A	c.(1777-1779)GAT>GAA	p.D593E	DENND5A_uc010rbw.1_Missense_Mutation_p.D593E|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	593	Poly-Asp.									liver(1)	1						TATCATCATCATCATGACACA	0.458000												
MDM2	4193	broad.mit.edu	37	12	69230464	69230464	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr12:69230464A>C	uc001sui.2	+	10	1140	c.853A>C	c.(853-855)ACT>CCT	p.T285P	MDM2_uc009zri.2_Missense_Mutation_p.T240P|MDM2_uc009zqx.2_Missense_Mutation_p.T230P|MDM2_uc009zqw.2_Intron|MDM2_uc001suk.2_Intron|MDM2_uc001sun.3_Missense_Mutation_p.T104P|MDM2_uc009zqz.2_Missense_Mutation_p.T232P|MDM2_uc009zra.2_Intron|MDM2_uc001sum.1_Intron|MDM2_uc009zrd.2_5'UTR|MDM2_uc009zrc.2_Intron|MDM2_uc009zre.2_Intron|MDM2_uc009zrf.2_Intron|MDM2_uc001suo.2_Missense_Mutation_p.T79P|MDM2_uc009zrg.2_Intron|MDM2_uc009zrh.2_Intron	NM_002392	NP_002383	Q00987	MDM2_HUMAN	mouse double minute 2 homolog isoform MDM2	279	Necessary for interaction with USP2.|ARF-binding.|Asp/Glu-rich (acidic).|Interaction with MTBP (By similarity).|Region II.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|central_nervous_system(1)	3	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ATATCAAGTTACTGTGTATCA	0.323000			A		sarcoma|glioma|colorectal|other							
CMKLR1	1240	broad.mit.edu	37	12	108686331	108686331	+	Missense_Mutation	SNP	G	G	A	rs148287464	by1000genomes	TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr12:108686331G>A	uc009zuw.2	-	3	600	c.409C>T	c.(409-411)CGC>TGC	p.R137C	CMKLR1_uc001tmw.2_Missense_Mutation_p.R137C|CMKLR1_uc001tmv.2_Missense_Mutation_p.R135C|CMKLR1_uc009zuv.2_Missense_Mutation_p.R137C	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	137	Cytoplasmic (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GAGATGCAGCGGTCAGAGCTG	0.557000												
SLITRK5	26050	broad.mit.edu	37	13	88329455	88329455	+	Silent	SNP	C	C	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr13:88329455C>A	uc001vln.2	+	2	2031	c.1812C>A	c.(1810-1812)CGC>CGA	p.R604R	SLITRK5_uc010tic.1_Silent_p.R363R	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	604	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCGACATGCGCTCCATTAAGT	0.567000												
C14orf118	55668	broad.mit.edu	37	14	76620846	76620846	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr14:76620846G>A	uc001xsh.2	+	2	226	c.140G>A	c.(139-141)CGT>CAT	p.R47H	C14orf118_uc001xsi.2_Missense_Mutation_p.R47H|C14orf118_uc001xsj.1_Missense_Mutation_p.R47H|C14orf118_uc001xsk.1_Missense_Mutation_p.R47H|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	47	Arg-rich.									ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		GGTCGGAAGCGTCGTTCTGAC	0.582000												
SEPT12	124404	broad.mit.edu	37	16	4833960	4833960	+	Missense_Mutation	SNP	C	C	T	rs144420035	byFrequency	TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr16:4833960C>T	uc002cxq.2	-	5	625	c.484G>A	c.(484-486)GTG>ATG	p.V162M	SEPT12_uc002cxr.2_Intron|SEPT12_uc010bty.2_RNA	NM_144605	NP_653206	Q8IYM1	SEP12_HUMAN	septin 12 isoform 2	162					cell cycle|cell division	cleavage furrow|midbody|perinuclear region of cytoplasm|septin complex|spindle|stress fiber	GDP binding|GTP binding|phosphatidylinositol binding|protein homodimerization activity			skin(1)	1						ACAAAGTACACGCAGCAGTGC	0.632000												
KCNH6	81033	broad.mit.edu	37	17	61601589	61601589	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr17:61601589C>T	uc002jay.2	+	2	246	c.166C>T	c.(166-168)CGA>TGA	p.R56*	KCNH6_uc002jax.1_Nonsense_Mutation_p.R56*|KCNH6_uc010wpl.1_5'UTR|KCNH6_uc010wpm.1_Nonsense_Mutation_p.R56*|KCNH6_uc002jaz.1_Nonsense_Mutation_p.R56*	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	56	PAS.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	CGGCTACTCCCGAGTGGAGGT	0.617000												
PITPNC1	26207	broad.mit.edu	37	17	65628319	65628319	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr17:65628319G>A	uc002jgc.2	+	6	774	c.427G>A	c.(427-429)GAT>AAT	p.D143N	PITPNC1_uc002jgb.2_Missense_Mutation_p.D143N	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	143					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			TATTGCCTGCGATGAAATTCC	0.358000												
TUBB4	10382	broad.mit.edu	37	19	6495726	6495726	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr19:6495726G>A	uc002mfg.1	-	4	891	c.784C>T	c.(784-786)CGC>TGC	p.R262C	TUBB4_uc002mff.1_Missense_Mutation_p.R190C|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	262					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		AAGTGCAGGCGAGGAAAGGGA	0.677000												
GALNT13	114805	broad.mit.edu	37	2	155099307	155099307	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr2:155099307G>A	uc002tyr.3	+	6	1142	c.575G>A	c.(574-576)CGT>CAT	p.R192H	GALNT13_uc002tyt.3_Missense_Mutation_p.R192H|GALNT13_uc010foc.1_Missense_Mutation_p.R11H	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	192	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						ATACGTGCCCGTCTTCGAGGA	0.423000												
CERKL	375298	broad.mit.edu	37	2	182409462	182409462	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr2:182409462T>G	uc002unx.2	-	12	1509	c.1408A>C	c.(1408-1410)AAA>CAA	p.K470Q	CERKL_uc002uny.2_Missense_Mutation_p.K444Q|CERKL_uc010zfm.1_Missense_Mutation_p.K426Q|CERKL_uc002unz.2_Missense_Mutation_p.K192Q|CERKL_uc002uoa.2_Missense_Mutation_p.K375Q|CERKL_uc002uob.2_Missense_Mutation_p.K192Q|CERKL_uc002uoc.2_Missense_Mutation_p.K331Q|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Missense_Mutation_p.K239Q|CERKL_uc002unw.2_Missense_Mutation_p.K40Q	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	470					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TTCAGGTGTTTTATAAATTCT	0.289000												
CLK1	1195	broad.mit.edu	37	2	201722526	201722526	+	Silent	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr2:201722526G>A	uc002uwe.2	-	7	928	c.747C>T	c.(745-747)TAC>TAT	p.Y249Y	CLK1_uc002uwd.2_Silent_p.Y72Y|CLK1_uc010zhi.1_Silent_p.Y291Y|CLK1_uc002uwf.2_Silent_p.Y23Y|CLK1_uc002uwg.2_Silent_p.Y98Y|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	249	Protein kinase.				cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						TAATGAAGTCGTAAGTACTAA	0.363000												
HJURP	55355	broad.mit.edu	37	2	234749948	234749948	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr2:234749948T>C	uc002vvg.2	-	8	1544	c.1478A>G	c.(1477-1479)AAA>AGA	p.K493R	HJURP_uc010znd.1_Missense_Mutation_p.K432R|HJURP_uc010zne.1_Missense_Mutation_p.K401R	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	493					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		ACTTTTTGCTTTTGCTTTGCT	0.502000												
ASTE1	28990	broad.mit.edu	37	3	130737361	130737361	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr3:130737361A>C	uc003env.1	-	4	1944	c.1502T>G	c.(1501-1503)ATC>AGC	p.I501S	ASTE1_uc010htm.1_Missense_Mutation_p.I501S|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	501					DNA repair		nuclease activity				0						AGGGCTGTTGATTATGGCAAT	0.433000												
GPR87	53836	broad.mit.edu	37	3	151012949	151012949	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr3:151012949C>G	uc003eyt.2	-	3	446	c.85G>C	c.(85-87)GGG>CGG	p.G29R	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	29	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTTCCTGGCCCGTCGCTCCTG	0.483000												
HDAC3	8841	broad.mit.edu	37	5	141014457	141014457	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr5:141014457C>T	uc003llf.2	-	3	268	c.202G>A	c.(202-204)GAC>AAC	p.D68N	HDAC3_uc003lle.1_Missense_Mutation_p.D11N|HDAC3_uc010jgd.1_Intron|HDAC3_uc010jge.1_Intron|RELL2_uc003lli.2_5'Flank|RELL2_uc003llh.2_5'Flank|RELL2_uc003llg.2_5'Flank|RELL2_uc010jgf.2_5'Flank	NM_003883	NP_003874	O15379	HDAC3_HUMAN	histone deacetylase 3	68	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	TGCAGGAAGTCAATGTAGTCC	0.542000												
DDX56	54606	broad.mit.edu	37	7	44611094	44611094	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr7:44611094G>T	uc003tlg.2	-	6	1530	c.887C>A	c.(886-888)TCC>TAC	p.S296Y	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Missense_Mutation_p.S232Y|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Missense_Mutation_p.S296Y|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	296	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						GGCAGACCTGGAGCGCAGTGG	0.438000												
FBXL13	222235	broad.mit.edu	37	7	102572363	102572363	+	Nonsense_Mutation	SNP	G	G	A	rs149803390		TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr7:102572363G>A	uc003vaq.2	-	9	1169	c.742C>T	c.(742-744)CAA>TAA	p.Q248*	FBXL13_uc010liq.1_Nonsense_Mutation_p.Q63*|FBXL13_uc010lir.1_Nonsense_Mutation_p.Q248*|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Nonsense_Mutation_p.Q248*|LRRC17_uc003vat.2_Intron|LRRC17_uc003vau.2_Intron	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	248	LRR 1.										0						TTCAACTCTTGCAAGTTCCTA	0.353000												
XKR6	286046	broad.mit.edu	37	8	10755990	10755990	+	Silent	SNP	C	C	T			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr8:10755990C>T	uc003wtk.1	-	3	1425	c.1398G>A	c.(1396-1398)CCG>CCA	p.P466P		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	466						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CAGTGGTCTCCGGGTCTCTGT	0.473000												
NCALD	83988	broad.mit.edu	37	8	102731642	102731642	+	Silent	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr8:102731642G>A	uc003yke.2	-	2	585	c.216C>T	c.(214-216)TTC>TTT	p.F72F	NCALD_uc003ykf.2_Silent_p.F72F|NCALD_uc003ykg.2_Silent_p.F72F|NCALD_uc003ykh.2_Silent_p.F72F|NCALD_uc003yki.2_Silent_p.F72F|NCALD_uc003ykj.2_Silent_p.F72F|NCALD_uc003ykk.2_Silent_p.F72F|NCALD_uc003ykl.2_Silent_p.F72F	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	72	EF-hand 2.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			CATTTGCATCGAAGGTGCGGA	0.443000												
SEC16A	9919	broad.mit.edu	37	9	139370971	139370971	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr9:139370971G>A	uc004chx.2	-	3	1406	c.1097C>T	c.(1096-1098)TCA>TTA	p.S366L	SEC16A_uc004chv.3_5'Flank|SEC16A_uc004chw.2_Missense_Mutation_p.S366L|SEC16A_uc010nbn.2_Missense_Mutation_p.S366L|SEC16A_uc010nbo.1_Missense_Mutation_p.S366L	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	188					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		TGAAGCTCCTGAGTCTGCTTC	0.582000												
SATL1	340562	broad.mit.edu	37	X	84363373	84363373	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chrX:84363373G>A	uc011mqx.1	-	1	602	c.602C>T	c.(601-603)CCA>CTA	p.P201L	SATL1_uc004een.2_Missense_Mutation_p.P201L	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	14	Gln-rich.						N-acetyltransferase activity			breast(2)	2						GCTGATGCCTGGTTGTTGCAC	0.572000												
ARID1A	8289	broad.mit.edu	37	1	27057722	27057723	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr1:27057721_27057722C>CA	uc001bmv.1	+	2	1802_1803	c.1429_1430C>CA	c.(1429-1431)cacfs	p.H477fs	ARID1A_uc001bmt.1_Frame_Shift_Ins_p.H477fs|ARID1A_uc001bmu.1_Frame_Shift_Ins_p.H477fs|ARID1A_uc001bmw.1_Frame_Shift_Ins_p.H94fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 1, mRNA.	477					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	SWI/SNF complex|nBAF complex|npBAF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCAAAGTCCTCACCCTCAGCAG	0.545			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""							
BZRAP1	9256	broad.mit.edu	37	17	56386384	56386385	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-8365-01A-21D-2340-08	TCGA-BR-8365-10A-01D-2341-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	094f7fc0-9c0c-4dad-aad5-d1b4d91b976a	10f5d5aa-736e-4108-a459-c3274df8814e	g.chr17:56386383_56386384C>CT	uc002ivx.4	-	21	5120_5121	c.4249_4250G>AG	c.(4249-4251)agcfs	p.S1417fs	BZRAP1_uc002ivw.3_5'Flank|BZRAP1_uc010dcs.3_Frame_Shift_Ins_p.S1357fs|BZRAP1_uc010wnt.2_Frame_Shift_Ins_p.S1417fs	NM_004758	NP_004749	O95153	RIMB1_HUMAN	Homo sapiens benzodiazapine receptor (peripheral) associated protein 1 (BZRAP1), transcript variant 1, mRNA.	1417						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCGCCTGCGGCTTGGGGGCTTC	0.653