Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
TTC4	7268	broad.mit.edu	37	1	55186864	55186864	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr1:55186864G>A	uc001cxx.3	+	4	473	c.420G>A	c.(418-420)GTG>GTA	p.V140V	C1orf175_uc001cxq.2_RNA|TTC4_uc001cxw.3_Silent_p.V140V|TTC4_uc001cxv.2_Silent_p.V151V	NM_004623	NP_004614	O95801	TTC4_HUMAN	tetratricopeptide repeat domain 4	140	TPR 2.						binding				0						TCAATGATGTGACAGCTGCCA	0.343000												
TLR5	7100	broad.mit.edu	37	1	223285764	223285764	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr1:223285764C>A	uc001hnv.1	-	4	1056	c.610G>T	c.(610-612)GCA>TCA	p.A204S	TLR5_uc001hnw.1_Missense_Mutation_p.A204S	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	204	Extracellular (Potential).				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		CTATTAGCTGCGAGGCTAAAA	0.428000												
OBSCN	84033	broad.mit.edu	37	1	228481244	228481244	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr1:228481244C>T	uc009xez.1	+	41	11102	c.11058C>T	c.(11056-11058)CTC>CTT	p.L3686L	OBSCN_uc001hsn.2_Silent_p.L3686L|OBSCN_uc001hsq.1_Silent_p.L942L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3686	Ig-like 37.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCCGCGGCCTCGTGGCAGAGG	0.642000												
MTR	4548	broad.mit.edu	37	1	237026774	237026774	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr1:237026774C>T	uc001hyi.3	+	22	2748	c.2325C>T	c.(2323-2325)ATC>ATT	p.I775I	MTR_uc010pxw.1_Silent_p.I368I|MTR_uc010pxx.1_Silent_p.I724I|MTR_uc010pxy.1_Silent_p.I629I	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	775	B12-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGGCACCATCGTGCTGGCCA	0.547000												
GAD2	2572	broad.mit.edu	37	10	26581413	26581413	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr10:26581413C>T	uc001isp.2	+	14	1909	c.1406C>T	c.(1405-1407)GCG>GTG	p.A469V	GAD2_uc001isq.2_Missense_Mutation_p.A469V	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	469					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	GGGTTTGAAGCGCATGTTGAT	0.448000												
PTCHD3	374308	broad.mit.edu	37	10	27688039	27688039	+	Silent	SNP	A	A	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr10:27688039A>T	uc001itu.2	-	4	1606	c.1488T>A	c.(1486-1488)ACT>ACA	p.T496T		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	496	SSD.|Helical; (Potential).				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CCAGGATGTTAGTGATGGTGG	0.398000												
CHAT	1103	broad.mit.edu	37	10	50835788	50835788	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr10:50835788C>T	uc001jhz.2	+	7	1221	c.1068C>T	c.(1066-1068)GAC>GAT	p.D356D	CHAT_uc001jhv.1_Silent_p.D238D|CHAT_uc001jhx.1_Silent_p.D238D|CHAT_uc001jhy.1_Silent_p.D238D|CHAT_uc001jia.2_Silent_p.D238D|CHAT_uc010qgs.1_Silent_p.D238D	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	356					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TGACGTCTGACGGGAGGAGCG	0.582000												
RRP12	23223	broad.mit.edu	37	10	99141471	99141471	+	Splice_Site	SNP	C	C	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr10:99141471C>G	uc001knf.2	-	11	1459	c.1320_splice	c.e11+1	p.K440_splice	RRP12_uc009xvm.2_Splice_Site_p.K158_splice|RRP12_uc010qou.1_Splice_Site_p.K379_splice|RRP12_uc009xvn.2_Splice_Site_p.K340_splice	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1							integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		AGTTGCAGTACCTTGAGGCTC	0.607000												
MRGPRX4	117196	broad.mit.edu	37	11	18194966	18194966	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr11:18194966C>T	uc001mnv.1	+	1	583	c.163C>T	c.(163-165)CGC>TGC	p.R55C		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	55	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CCTGGGCTACCGCATGCGCAG	0.547000												
DCDC1	341019	broad.mit.edu	37	11	31327931	31327931	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr11:31327931C>A	uc001msv.2	-	5	641	c.439G>T	c.(439-441)GCA>TCA	p.A147S	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	147					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					GAGAACTCTGCAACCCTGAAG	0.318000												
RIN1	9610	broad.mit.edu	37	11	66099763	66099763	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr11:66099763C>T	uc001ohn.1	-	10	2463	c.2336G>A	c.(2335-2337)CGG>CAG	p.R779Q	RIN1_uc010roy.1_Missense_Mutation_p.R410Q|RIN1_uc009yrd.1_Missense_Mutation_p.R472Q|RIN1_uc010roz.1_Missense_Mutation_p.R674Q|RIN1_uc010rpa.1_Missense_Mutation_p.R613Q	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	779					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						CTCTGCTGCCCGGCTTCCCTC	0.622000												
DLG2	1740	broad.mit.edu	37	11	84634228	84634228	+	Translation_Start_Site	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr11:84634228C>T	uc001paj.2	-	1	238	c.-65G>A	c.(-67--63)TCGTG>TCATG		DLG2_uc010rsz.1_Translation_Start_Site|DLG2_uc010rta.1_Translation_Start_Site|DLG2_uc001pak.2_Intron|DLG2_uc001pal.1_Translation_Start_Site	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2							cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CCCACACACACGATCCTGGGC	0.458000												
CLDN25	644672	broad.mit.edu	37	11	113650730	113650730	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr11:113650730G>T	uc009yyw.1	+	1	213	c.213G>T	c.(211-213)TTG>TTT	p.L71F		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	71	Extracellular (Potential).					integral to membrane|tight junction	structural molecule activity				0						AATCCTTCTTGTCTCTGCCCC	0.567000												
OR10G9	219870	broad.mit.edu	37	11	123893746	123893746	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr11:123893746G>A	uc010sad.1	+	1	27	c.27G>A	c.(25-27)GCG>GCA	p.A9A		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TCGTGACAGCGTTCATCCTCA	0.542000												
NTN4	59277	broad.mit.edu	37	12	96077367	96077367	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr12:96077367C>G	uc001tei.2	-	6	1750	c.1301G>C	c.(1300-1302)TGC>TCC	p.C434S	NTN4_uc009ztf.2_Missense_Mutation_p.C434S|NTN4_uc009ztg.2_Missense_Mutation_p.C397S	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	434	Laminin EGF-like 3.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						TCCCACCATGCACCTGTCACA	0.597000												
GAS2L3	283431	broad.mit.edu	37	12	101016092	101016092	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr12:101016092C>G	uc001thu.2	+	9	914	c.688C>G	c.(688-690)CAT>GAT	p.H230D	GAS2L3_uc009zty.2_Missense_Mutation_p.H230D|GAS2L3_uc001thv.2_Missense_Mutation_p.H126D	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	230	GAR.				cell cycle arrest					skin(1)	1						TAGTTGTTCTCATCGATTTTC	0.323000												
GAS2L3	283431	broad.mit.edu	37	12	101016095	101016095	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr12:101016095C>T	uc001thu.2	+	9	917	c.691C>T	c.(691-693)CGA>TGA	p.R231*	GAS2L3_uc009zty.2_Nonsense_Mutation_p.R231*|GAS2L3_uc001thv.2_Nonsense_Mutation_p.R127*	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	231	GAR.				cell cycle arrest					skin(1)	1						TTGTTCTCATCGATTTTCTAT	0.318000												
GAS2L3	283431	broad.mit.edu	37	12	101017925	101017925	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr12:101017925C>G	uc001thu.2	+	10	1568	c.1342C>G	c.(1342-1344)CCA>GCA	p.P448A	GAS2L3_uc009zty.2_Missense_Mutation_p.P448A|GAS2L3_uc001thv.2_Missense_Mutation_p.P344A	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	448					cell cycle arrest					skin(1)	1						CAAGGTTATTCCAGCCCAGAA	0.413000												
GAS2L3	283431	broad.mit.edu	37	12	101018070	101018070	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr12:101018070C>A	uc001thu.2	+	10	1713	c.1487C>A	c.(1486-1488)TCC>TAC	p.S496Y	GAS2L3_uc009zty.2_Missense_Mutation_p.S496Y|GAS2L3_uc001thv.2_Missense_Mutation_p.S392Y	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	496					cell cycle arrest					skin(1)	1						TCAAATTCATCCTCAAAATGT	0.353000												
GAS2L3	283431	broad.mit.edu	37	12	101018357	101018357	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr12:101018357C>G	uc001thu.2	+	10	2000	c.1774C>G	c.(1774-1776)CAG>GAG	p.Q592E	GAS2L3_uc009zty.2_Missense_Mutation_p.Q592E|GAS2L3_uc001thv.2_Missense_Mutation_p.Q488E	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	592					cell cycle arrest					skin(1)	1						AAAGCAGCCTCAGAATAAAAG	0.443000												
GPR109A	338442	broad.mit.edu	37	12	123187315	123187315	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr12:123187315G>A	uc001ucx.1	-	1	590	c.516C>T	c.(514-516)GGC>GGT	p.G172G	GPR81_uc001ucw.1_Intron	NM_177551	NP_808219	Q8TDS4	HCAR2_HUMAN	G protein-coupled receptor 109A	172	Extracellular (Potential).				negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	AATTTGCACCGCCATTCTGGA	0.542000												
N4BP2L2	10443	broad.mit.edu	37	13	33016759	33016759	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr13:33016759C>G	uc010abe.1	-	7	1937	c.1915G>C	c.(1915-1917)GAA>CAA	p.E639Q	N4BP2L2_uc001uug.2_Missense_Mutation_p.E522Q|N4BP2L2_uc010abd.1_Missense_Mutation_p.E552Q|N4BP2L2_uc001uuh.2_Missense_Mutation_p.E470Q|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.E624Q	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TGTAAAATTTCTGGAGAAATA	0.338000												
GPC5	2262	broad.mit.edu	37	13	92101163	92101163	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr13:92101163G>A	uc010tif.1	+	2	678	c.312G>A	c.(310-312)GCG>GCA	p.A104A		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	104						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CTCGAAATGCGGCTGCTTTTC	0.438000												
RASA3	22821	broad.mit.edu	37	13	114806557	114806557	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr13:114806557G>C	uc001vui.2	-	4	422	c.291C>G	c.(289-291)ATC>ATG	p.I97M	RASA3_uc010tkk.1_Missense_Mutation_p.I65M|RASA3_uc001vuj.2_Translation_Start_Site|RASA3_uc010tkl.1_Intron	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	97					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			CCTCCTTCTGGATGGCCACCT	0.612000												
PRKD1	5587	broad.mit.edu	37	14	30100211	30100211	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr14:30100211T>C	uc001wqh.2	-	10	1590	c.1409A>G	c.(1408-1410)GAA>GGA	p.E470G		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	470	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		AGACAAAATTTCAGATAAAGG	0.318000												
ARF6	382	broad.mit.edu	37	14	50360781	50360781	+	Silent	SNP	C	C	T	rs117373659	by1000genomes	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr14:50360781C>T	uc001wxg.3	+	2	948	c.327C>T	c.(325-327)GAC>GAT	p.D109D		NM_001663	NP_001654	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	109					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding				0	all_epithelial(31;0.000822)|Breast(41;0.0117)					TTATCAATGACCGGGAGATGA	0.582000												
PAPLN	89932	broad.mit.edu	37	14	73730411	73730411	+	Missense_Mutation	SNP	C	C	T	rs139258651	byFrequency	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr14:73730411C>T	uc010ttx.1	+	19	2945	c.2782C>T	c.(2782-2784)CGG>TGG	p.R928W	PAPLN_uc001xnw.3_Missense_Mutation_p.R901W|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.R912W|PAPLN_uc010arm.2_Missense_Mutation_p.R127W|PAPLN_uc010arn.2_Missense_Mutation_p.R128W	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	928	Ig-like C2-type 1.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCAGTTGGTGCGGCTCTCCTG	0.637000												
MAPK8IP3	23162	broad.mit.edu	37	16	1808983	1808983	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr16:1808983C>T	uc002cmk.2	+	10	1350	c.1230C>T	c.(1228-1230)CGC>CGT	p.R410R	MAPK8IP3_uc002cml.2_Intron|MAPK8IP3_uc010uvl.1_Silent_p.R411R	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	410					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCCTAGTGCGCGATGATTTCT	0.602000												
ABCC1	4363	broad.mit.edu	37	16	16126992	16126992	+	Silent	SNP	C	C	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr16:16126992C>A	uc010bvi.2	+	6	817	c.642C>A	c.(640-642)TCC>TCA	p.S214S	ABCC1_uc010bvj.2_Silent_p.S214S|ABCC1_uc010bvk.2_Silent_p.S214S|ABCC1_uc010bvl.2_Silent_p.S214S|ABCC1_uc010bvm.2_Silent_p.S214S|ABCC1_uc002del.3_Silent_p.S98S|ABCC1_uc010bvn.2_Silent_p.S77S	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	214	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCAGCGCTTCCTTCCTGTCGA	0.478000												
SPN	6693	broad.mit.edu	37	16	29675436	29675436	+	Silent	SNP	C	C	T	rs139180392	byFrequency	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr16:29675436C>T	uc002dtm.2	+	2	523	c.387C>T	c.(385-387)ACC>ACT	p.T129T	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Silent_p.T129T|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	129	Extracellular (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						GATCCCACACCGTGACAGGTG	0.532000												
MYBBP1A	10514	broad.mit.edu	37	17	4457494	4457494	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr17:4457494T>C	uc002fyb.3	-	3	436	c.374A>G	c.(373-375)AAG>AGG	p.K125R	MYBBP1A_uc002fxz.3_Missense_Mutation_p.K125R	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	125	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						TCTCACCTTCTTCACCTGATG	0.567000												
TP53	7157	broad.mit.edu	37	17	7577568	7577568	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr17:7577568C>A	uc002gim.2	-	7	907	c.713G>T	c.(712-714)TGT>TTT	p.C238F	TP53_uc002gig.1_Missense_Mutation_p.C238F|TP53_uc002gih.2_Missense_Mutation_p.C238F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C106F|TP53_uc010cng.1_Missense_Mutation_p.C106F|TP53_uc002gii.1_Missense_Mutation_p.C106F|TP53_uc010cnh.1_Missense_Mutation_p.C238F|TP53_uc010cni.1_Missense_Mutation_p.C238F|TP53_uc002gij.2_Missense_Mutation_p.C238F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C145F|TP53_uc002gio.2_Missense_Mutation_p.C106F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	238	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	C -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> Y (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C238Y(47)|p.C238F(34)|p.C238S(18)|p.C238R(14)|p.0?(7)|p.C238*(4)|p.C238W(2)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.C238fs*9(1)|p.M237_N239delMCN(1)|p.C238fs*21(1)|p.C238del(1)|p.C238G(1)|p.C238C(1)|p.M237fs*1(1)|p.C145F(1)|p.H233fs*6(1)|p.H233_C242del10(1)|p.N239_C242del(1)|p.M237_C238insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAACTGTTACACATGTAGTT	0.572000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
MYH1	4619	broad.mit.edu	37	17	10417440	10417440	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr17:10417440C>T	uc002gmo.2	-	7	629	c.535G>A	c.(535-537)GGA>AGA	p.G179R	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	179	Myosin head-like.|ATP (Potential).					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CCAGATTCTCCGCTGTCAAAG	0.418000												
POLG2	11232	broad.mit.edu	37	17	62488810	62488810	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr17:62488810G>A	uc002jei.2	-	3	852	c.769C>T	c.(769-771)CGT>TGT	p.R257C	POLG2_uc010deg.1_Missense_Mutation_p.R257C	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	257					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			AGTCGATGACGTAACCAGAAA	0.358000												
APOH	350	broad.mit.edu	37	17	64212961	64212961	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr17:64212961C>T	uc002jfn.3	-	6	788	c.729G>A	c.(727-729)CCG>CCA	p.P243P		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	243	Sushi 4.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			CTATTTCTTCCGGGCCATCCA	0.423000												
KCNJ16	3773	broad.mit.edu	37	17	68128638	68128638	+	Missense_Mutation	SNP	G	G	A	rs144258139		TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr17:68128638G>A	uc002jin.2	+	5	896	c.410G>A	c.(409-411)CGC>CAC	p.R137H	KCNJ16_uc002jio.2_Missense_Mutation_p.R137H|KCNJ16_uc002jip.2_Missense_Mutation_p.R137H|KCNJ16_uc002jiq.2_Missense_Mutation_p.R169H	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	137	Extracellular (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					TATGGTTATCGCTGTGTTACT	0.458000												
SETBP1	26040	broad.mit.edu	37	18	42532485	42532485	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr18:42532485G>A	uc010dni.2	+	4	3476	c.3180G>A	c.(3178-3180)ATG>ATA	p.M1060I		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1060						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CAATGCCTATGATGAACCTTG	0.488000									Schinzel-Giedion_syndrome			
CDH20	28316	broad.mit.edu	37	18	59221564	59221564	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr18:59221564C>T	uc010dps.1	+	11	2054	c.2042C>T	c.(2041-2043)GCG>GTG	p.A681V	CDH20_uc002lif.2_Missense_Mutation_p.A675V	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	681	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TTCGACATCGCGGCCATGTGG	0.667000												
RDH8	50700	broad.mit.edu	37	19	10132297	10132297	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr19:10132297G>A	uc002mmr.2	+	6	1057	c.808G>A	c.(808-810)GTG>ATG	p.V270M		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	270					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	GCTCAAAACCGTGGATTCCTC	0.607000												
CYP4F22	126410	broad.mit.edu	37	19	15651382	15651382	+	Missense_Mutation	SNP	C	C	T	rs144569785		TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr19:15651382C>T	uc002nbh.3	+	8	960	c.793C>T	c.(793-795)CGG>TGG	p.R265W		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	265						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						GCGGAGGTTCCGGCAGGCCTG	0.617000												
NLRP12	91662	broad.mit.edu	37	19	54314031	54314031	+	Silent	SNP	G	G	A	rs147080557	by1000genomes	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr19:54314031G>A	uc002qch.3	-	3	1102	c.882C>T	c.(880-882)GAC>GAT	p.D294D	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.D294D|NLRP12_uc002qcj.3_Silent_p.D294D|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.D294D	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	294	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CATCGAAGCCGTCGATGATGA	0.582000												
LILRB5	10990	broad.mit.edu	37	19	54758651	54758651	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr19:54758651G>C	uc002qex.2	-	6	1313	c.1202C>G	c.(1201-1203)TCC>TGC	p.S401C	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.S392C|LILRB5_uc002qey.2_Missense_Mutation_p.S401C|LILRB5_uc002qez.2_Missense_Mutation_p.S301C|LILRB5_uc002qfa.1_Missense_Mutation_p.S291C|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	401	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTAGGGGTAGGACCTGATTGC	0.567000												
TTYH1	57348	broad.mit.edu	37	19	54932467	54932467	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr19:54932467G>A	uc002qfq.2	+	3	414	c.322G>A	c.(322-324)GGT>AGT	p.G108S	TTYH1_uc010yey.1_Missense_Mutation_p.G157S|TTYH1_uc002qfr.2_Missense_Mutation_p.G108S|TTYH1_uc002qft.2_Missense_Mutation_p.G108S|TTYH1_uc002qfu.1_Missense_Mutation_p.G23S	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	108	Helical; Name=2; (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		CATTGGCATCGGTTTCTATGG	0.642000												
RAB10	10890	broad.mit.edu	37	2	26332773	26332773	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr2:26332773G>T	uc002rgv.2	+	3	1074	c.325G>T	c.(325-327)GAG>TAG	p.E109*		NM_016131	NP_057215	P61026	RAB10_HUMAN	ras-related GTP-binding protein RAB10	109					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAACATAGATGAGGTAAGACC	0.368000												
PLB1	151056	broad.mit.edu	37	2	28812361	28812361	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr2:28812361G>A	uc002rmb.1	+	27	1860	c.1860G>A	c.(1858-1860)AGG>AGA	p.R620R	PLB1_uc010ezj.1_Silent_p.R609R|PLB1_uc002rmc.2_Silent_p.R308R|PLB1_uc002rmd.1_Silent_p.R130R	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	620	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					ATGACACAAGGGAAGATTTTA	0.488000												
TMEM178	130733	broad.mit.edu	37	2	39893123	39893123	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr2:39893123G>A	uc002rrt.2	+	1	34	c.9G>A	c.(7-9)CCG>CCA	p.P3P	TMEM178_uc010fam.1_Silent_p.P3P	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	3						integral to membrane					0		all_hematologic(82;0.248)				CCATGGAGCCGCGGGCGCTCG	0.473000												
PSD4	23550	broad.mit.edu	37	2	113942985	113942985	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr2:113942985G>A	uc002tjc.2	+	4	1400	c.1217G>A	c.(1216-1218)TGG>TAG	p.W406*	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Nonsense_Mutation_p.W405*|PSD4_uc002tjf.2_5'UTR	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	406					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GGTCCTTTTTGGCCCCAGGTG	0.512000												
C2orf85	285093	broad.mit.edu	37	2	242814250	242814250	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr2:242814250C>T	uc010fzu.1	+	2	566	c.543C>T	c.(541-543)ACC>ACT	p.T181T		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	181						integral to membrane				ovary(1)	1						GCACTGGCACCGTCTCCAGGG	0.662000												
KIAA0406	9675	broad.mit.edu	37	20	36627656	36627656	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr20:36627656C>T	uc002xhl.2	-	6	2936	c.2727G>A	c.(2725-2727)CAG>CAA	p.Q909Q	KIAA0406_uc002xhm.2_Silent_p.Q909Q	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	909							binding				0		Myeloproliferative disorder(115;0.00874)				AGGGCCAGGCCTGATGAGCCA	0.557000												
ZHX3	23051	broad.mit.edu	37	20	39833134	39833134	+	Silent	SNP	G	G	A	rs113667928	byFrequency	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr20:39833134G>A	uc002xjs.1	-	3	801	c.423C>T	c.(421-423)AAC>AAT	p.N141N	ZHX3_uc002xjq.1_Silent_p.N141N|ZHX3_uc002xjr.1_Silent_p.N141N|ZHX3_uc002xjt.1_Silent_p.N141N|ZHX3_uc002xju.1_Silent_p.N141N|ZHX3_uc002xjv.1_Silent_p.N141N|ZHX3_uc002xjw.1_Silent_p.N141N|ZHX3_uc010ggg.1_Silent_p.N141N	NM_015035	NP_055850	Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	141					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Myeloproliferative disorder(115;0.00425)				GCTTGGCCACGTTCCACACAA	0.567000												
TOM1	10043	broad.mit.edu	37	22	35719519	35719519	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr22:35719519G>A	uc003ann.2	+	5	522	c.397G>A	c.(397-399)GAT>AAT	p.D133N	TOM1_uc011ami.1_Missense_Mutation_p.D100N|TOM1_uc011amj.1_5'UTR|TOM1_uc003ans.2_5'UTR|TOM1_uc011amk.1_Missense_Mutation_p.D95N|TOM1_uc003anp.2_Missense_Mutation_p.D133N|TOM1_uc011aml.1_Intron|TOM1_uc003ano.2_RNA|TOM1_uc003anq.2_Missense_Mutation_p.D127N|TOM1_uc003anr.2_5'UTR	NM_005488	NP_005479	O60784	TOM1_HUMAN	target of myb1 isoform 1	133	VHS.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			ovary(1)	1						CAGCTCGCCCGATCTGACAGG	0.617000												
ATP2B2	491	broad.mit.edu	37	3	10417266	10417266	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr3:10417266C>T	uc003bvt.2	-	11	1703	c.1264G>A	c.(1264-1266)GTG>ATG	p.V422M	ATP2B2_uc003bvv.2_Missense_Mutation_p.V377M|ATP2B2_uc003bvw.2_Missense_Mutation_p.V377M|ATP2B2_uc010hdo.2_Missense_Mutation_p.V127M	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	422	Extracellular (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TTGTTGACCACGAAGGTGTCC	0.562000												
FBLN2	2199	broad.mit.edu	37	3	13669425	13669425	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr3:13669425G>A	uc011avb.1	+	10	2509	c.2384G>A	c.(2383-2385)CGC>CAC	p.R795H	FBLN2_uc011auz.1_Missense_Mutation_p.R821H|FBLN2_uc011ava.1_Missense_Mutation_p.R842H|FBLN2_uc011avc.1_Missense_Mutation_p.R842H	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	795	EGF-like 4; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GCCAGGCAGCGCTGCATGGAT	0.627000												
MBD4	8930	broad.mit.edu	37	3	129152786	129152786	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr3:129152786G>T	uc003emh.1	-	5	1494	c.1318C>A	c.(1318-1320)CCT>ACT	p.P440T	MBD4_uc003emi.1_Missense_Mutation_p.P440T|MBD4_uc003emj.1_Missense_Mutation_p.P434T|MBD4_uc003emk.1_Missense_Mutation_p.P122T|MBD4_uc011bkw.1_Missense_Mutation_p.P440T	NM_003925	NP_003916	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	440					depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			ovary(1)|lung(1)	2						GACCGAGGAGGTGTCCATTTC	0.413000								BER_DNA_glycosylases				
EPHB1	2047	broad.mit.edu	37	3	134920403	134920403	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr3:134920403T>C	uc003eqt.2	+	12	2438	c.2218T>C	c.(2218-2220)TAT>CAT	p.Y740H	EPHB1_uc003equ.2_Missense_Mutation_p.Y301H	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	740	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						TGAGATGAATTATGTGCATCG	0.532000												
CLDN11	5010	broad.mit.edu	37	3	170150502	170150502	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr3:170150502G>A	uc003fgx.2	+	3	784	c.582G>A	c.(580-582)GCG>GCA	p.A194A	CLDN11_uc011bpt.1_Intron|CLDN11_uc003fgy.2_Silent_p.A110A	NM_005602	NP_005593	O75508	CLD11_HUMAN	claudin 11	194	Cytoplasmic (Potential).			RFYYTAGSSSPTHAKSAHV -> VSTTLRALAPRLMRRVPT YKRAARLPTEVL (in Ref. 1; AAC25187).	calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			central_nervous_system(1)	1	all_cancers(22;5.62e-23)|all_epithelial(15;7.54e-28)|all_lung(20;2.51e-17)|Lung NSC(18;1.02e-16)|Ovarian(172;0.000567)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			ACTACACTGCGGGCTCTAGCT	0.612000												
ECT2	1894	broad.mit.edu	37	3	172486836	172486836	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr3:172486836C>T	uc003fii.2	+	12	1376	c.1238C>T	c.(1237-1239)ACT>ATT	p.T413I	ECT2_uc010hwv.1_Missense_Mutation_p.T444I|ECT2_uc003fih.2_Missense_Mutation_p.T412I|ECT2_uc003fij.1_Missense_Mutation_p.T413I|ECT2_uc003fik.1_Missense_Mutation_p.T413I|ECT2_uc003fil.1_Missense_Mutation_p.T444I	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	413					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AAAAGCTCCACTCCAGTTCCT	0.348000												
ATP13A5	344905	broad.mit.edu	37	3	193081122	193081122	+	Missense_Mutation	SNP	G	G	T	rs12637558	byFrequency	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr3:193081122G>T	uc011bsq.1	-	3	287	c.287C>A	c.(286-288)TCC>TAC	p.S96Y		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	96					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding	p.S96Y(1)		ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CTTCAGTGTGGATAAGTAGAG	0.398000												
EPHA5	2044	broad.mit.edu	37	4	66217148	66217148	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr4:66217148G>A	uc003hcy.2	-	14	2660	c.2467C>T	c.(2467-2469)CGG>TGG	p.R823W	EPHA5_uc003hcx.2_Missense_Mutation_p.R755W|EPHA5_uc003hcz.2_Missense_Mutation_p.R801W|EPHA5_uc011cah.1_Missense_Mutation_p.R824W|EPHA5_uc011cai.1_Missense_Mutation_p.R802W|EPHA5_uc003hda.2_Missense_Mutation_p.R824W	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	823	Cytoplasmic (Potential).|Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						TCCAGTACCCGGGAAAGTCCA	0.433000										TSP Lung(17;0.13)		
RG9MTD2	93587	broad.mit.edu	37	4	100470352	100470352	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr4:100470352C>T	uc003huy.2	-	8	1226	c.913G>A	c.(913-915)GAT>AAT	p.D305N	RG9MTD2_uc003huz.3_Missense_Mutation_p.D305N|RG9MTD2_uc003hva.3_Missense_Mutation_p.D305N	NM_152292	NP_689505	Q8TBZ6	RG9D2_HUMAN	RNA (guanine-9-) methyltransferase domain	305							methyltransferase activity			ovary(2)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.7e-08)		TCACTGGAATCACTGTCCGAT	0.463000												
PCDH10	57575	broad.mit.edu	37	4	134073378	134073378	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr4:134073378G>C	uc003iha.2	+	1	2909	c.2083G>C	c.(2083-2085)GGG>CGG	p.G695R	PCDH10_uc003igz.2_Missense_Mutation_p.G695R	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	695	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		cggaggcggaggGTCAGGAGA	0.577000												
CTNND2	1501	broad.mit.edu	37	5	11364949	11364949	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr5:11364949G>A	uc003jfa.1	-	8	1376	c.1231C>T	c.(1231-1233)CGG>TGG	p.R411W	CTNND2_uc010itt.2_Missense_Mutation_p.R320W|CTNND2_uc011cmy.1_Missense_Mutation_p.R74W|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_5'UTR	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	411	ARM 1.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGCAGGGCCCGCAACTCTGGG	0.577000												
F2R	2149	broad.mit.edu	37	5	76028449	76028449	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr5:76028449C>T	uc003ken.3	+	2	664	c.399C>T	c.(397-399)GTC>GTT	p.V133V		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	133	Cytoplasmic (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	AAATGAAGGTCAAGAAGCCGG	0.512000												
FKBP5	2289	broad.mit.edu	37	6	35586920	35586920	+	Missense_Mutation	SNP	C	C	T	rs140297532	byFrequency	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr6:35586920C>T	uc011dte.1	-	5	664	c.461G>A	c.(460-462)CGG>CAG	p.R154Q	FKBP5_uc003okx.2_Missense_Mutation_p.R154Q|FKBP5_uc011dtf.1_Intron|FKBP5_uc003oky.2_Missense_Mutation_p.R154Q|FKBP5_uc003okz.2_Missense_Mutation_p.R154Q	NM_001145776	NP_001139248	Q13451	FKBP5_HUMAN	FK506 binding protein 5 isoform 1	154					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1						CTCTCCTTTCCGTTTGGTTCT	0.383000												
MCHR2	84539	broad.mit.edu	37	6	100382330	100382330	+	Silent	SNP	A	A	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr6:100382330A>G	uc003pqh.1	-	5	966	c.651T>C	c.(649-651)TAT>TAC	p.Y217Y	MCHR2_uc003pqi.1_Silent_p.Y217Y	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	217	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		AAATTAAAATATAGCACACCA	0.259000												
FAM162B	221303	broad.mit.edu	37	6	117083148	117083148	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr6:117083148C>A	uc003pxi.2	-	3	529	c.382G>T	c.(382-384)GCC>TCC	p.A128S		NM_001085480	NP_001078949	Q5T6X4	F162B_HUMAN	hypothetical protein LOC221303	128						integral to membrane					0						ACCCTTTTGGCTGACACTATC	0.418000												
TULP4	56995	broad.mit.edu	37	6	158870124	158870124	+	Missense_Mutation	SNP	G	G	A	rs35262826	byFrequency	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr6:158870124G>A	uc003qrf.2	+	4	1997	c.640G>A	c.(640-642)GGC>AGC	p.G214S	TULP4_uc011efo.1_Missense_Mutation_p.G214S|TULP4_uc003qrg.2_Missense_Mutation_p.G214S	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	214					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CGGTGTCCTCGGCATGTCCTG	0.602000												
DLL1	28514	broad.mit.edu	37	6	170592399	170592399	+	Missense_Mutation	SNP	G	G	T	rs144070852		TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr6:170592399G>T	uc003qxm.2	-	9	2438	c.1968C>A	c.(1966-1968)GAC>GAA	p.D656E		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	656	Cytoplasmic (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TGCTGTGCGCGTCCCTGACGG	0.677000												
TMEM195	392636	broad.mit.edu	37	7	15584510	15584510	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr7:15584510T>A	uc003stb.1	-	3	466	c.296A>T	c.(295-297)TAT>TTT	p.Y99F		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	99					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CTCCCAGATATAAATATAACT	0.353000												
CAMK2B	816	broad.mit.edu	37	7	44259793	44259793	+	Silent	SNP	C	C	T	rs149916298	byFrequency	TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr7:44259793C>T	uc003tkq.2	-	23	2079	c.1869G>A	c.(1867-1869)ACG>ACA	p.T623T	CAMK2B_uc003tkp.2_Silent_p.T499T|CAMK2B_uc003tkx.2_Silent_p.T459T|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Silent_p.T475T|CAMK2B_uc003tks.2_Silent_p.T474T|CAMK2B_uc003tku.2_Silent_p.T460T|CAMK2B_uc003tkv.2_Silent_p.T436T|CAMK2B_uc003tkt.2_Silent_p.T449T|CAMK2B_uc003tkw.2_Silent_p.T406T|CAMK2B_uc010kyc.2_Silent_p.T499T|CAMK2B_uc003tkn.2_Silent_p.T256T	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	623					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						CAATGTACTGCGTGAGCCGGA	0.637000												
ABCA13	154664	broad.mit.edu	37	7	48559747	48559747	+	Silent	SNP	G	G	C			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr7:48559747G>C	uc003toq.2	+	53	13933	c.13908G>C	c.(13906-13908)CTG>CTC	p.L4636L	ABCA13_uc010kys.1_Silent_p.L1711L|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Silent_p.L366L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4636					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AATATGACCTGACCCACAACT	0.448000												
SEMA3A	10371	broad.mit.edu	37	7	83614755	83614755	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr7:83614755C>G	uc003uhz.2	-	13	1806	c.1491G>C	c.(1489-1491)AAG>AAC	p.K497N		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	497	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ATAGTACCTGCTTAGTGGAAA	0.313000												
MTUS1	57509	broad.mit.edu	37	8	17601257	17601257	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr8:17601257C>T	uc003wxv.2	-	3	2617	c.2143G>A	c.(2143-2145)GAC>AAC	p.D715N	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.D715N|MTUS1_uc010lsz.2_Missense_Mutation_p.D715N	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	715						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		CCGCAGGAGTCAGGCTTGGAT	0.418000												
PXDNL	137902	broad.mit.edu	37	8	52384808	52384808	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr8:52384808C>T	uc003xqu.3	-	8	852	c.751G>A	c.(751-753)GTC>ATC	p.V251I		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	251	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GTGAAGTAGACGGTATTTCCT	0.433000												
PREX2	80243	broad.mit.edu	37	8	69009347	69009347	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr8:69009347G>A	uc003xxv.1	+	22	2491	c.2464G>A	c.(2464-2466)GTG>ATG	p.V822M	PREX2_uc003xxu.1_Missense_Mutation_p.V822M|PREX2_uc011lez.1_Missense_Mutation_p.V757M	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	822					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ATATGGTGTCGTGTATGAGTA	0.463000												
APBA1	320	broad.mit.edu	37	9	72132004	72132004	+	Silent	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr9:72132004C>T	uc004ahh.2	-	2	399	c.123G>A	c.(121-123)CCG>CCA	p.P41P		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	41					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GCTGCTGCGGCGGCTGCTGCT	0.716000												
FLJ46321	389763	broad.mit.edu	37	9	84609979	84609979	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr9:84609979C>T	uc004amn.2	+	4	4641	c.4594C>T	c.(4594-4596)CGG>TGG	p.R1532W		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1532						integral to membrane					0						CCCCACTTGCCGGCGTCAGGT	0.532000												
SLC2A6	11182	broad.mit.edu	37	9	136341384	136341384	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr9:136341384G>A	uc004cee.2	-	4	632	c.537C>T	c.(535-537)TTC>TTT	p.F179F	SLC2A6_uc004cef.2_Silent_p.F179F|SLC2A6_uc004ceg.2_Silent_p.F179F|SLC2A6_uc011mdj.1_Silent_p.F179F	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	179	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		ACAGGGATCCGAACACTGCCA	0.652000												
ZNF182	7569	broad.mit.edu	37	X	47836536	47836536	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:47836536G>A	uc004dir.2	-	7	1296	c.950C>T	c.(949-951)CCT>CTT	p.P317L	ZNF182_uc004dis.2_Missense_Mutation_p.P298L|ZNF182_uc004dit.2_Missense_Mutation_p.P317L|ZNF182_uc011mlu.1_Missense_Mutation_p.P297L	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						ACATTCATAAGGTTTTTCTCC	0.413000												
HUWE1	10075	broad.mit.edu	37	X	53576261	53576261	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:53576261G>A	uc004dsp.2	-	67	10096	c.9694C>T	c.(9694-9696)CGC>TGC	p.R3232C	HUWE1_uc004dsn.2_Missense_Mutation_p.R2040C	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3232					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCACTGCTGCGCTGCAAGATG	0.512000												
USP51	158880	broad.mit.edu	37	X	55515254	55515254	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:55515254G>A	uc004dun.1	-	2	198	c.119C>T	c.(118-120)GCG>GTG	p.A40V	USP51_uc011moo.1_5'Flank	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	40					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						CCCCGCCGCCGCCTCCTCCAT	0.647000												
CAPN6	827	broad.mit.edu	37	X	110494255	110494255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:110494255G>A	uc004epc.1	-	8	1216	c.1048C>T	c.(1048-1050)CGA>TGA	p.R350*	CAPN6_uc011msu.1_Nonsense_Mutation_p.R95*	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	350	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						AGCTCCTTTCGGCCAAAAATA	0.498000												
STAG2	10735	broad.mit.edu	37	X	123220506	123220506	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:123220506G>A	uc004etz.3	+	29	3502	c.3163G>A	c.(3163-3165)GAC>AAC	p.D1055N	STAG2_uc004eua.2_Missense_Mutation_p.D1055N|STAG2_uc004eub.2_Missense_Mutation_p.D1055N|STAG2_uc004euc.2_Missense_Mutation_p.D1055N|STAG2_uc004eud.2_Missense_Mutation_p.D1055N|STAG2_uc004eue.2_Missense_Mutation_p.D1055N	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1055					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGGTGATGATGACACCATGTC	0.458000												
VGLL1	51442	broad.mit.edu	37	X	135631089	135631089	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:135631089G>A	uc004ezy.2	+	3	726	c.556G>A	c.(556-558)GCC>ACC	p.A186T	MIR934_hsa-mir-934|MI0005756_5'Flank	NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)					GGAATCTGCCGCCAGGGAGAA	0.577000												
SLITRK2	84631	broad.mit.edu	37	X	144905642	144905642	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:144905642G>C	uc004fcd.2	+	5	2689	c.1699G>C	c.(1699-1701)GAG>CAG	p.E567Q	SLITRK2_uc010nsp.2_Missense_Mutation_p.E567Q|SLITRK2_uc010nso.2_Missense_Mutation_p.E567Q|SLITRK2_uc011mwq.1_Missense_Mutation_p.E567Q|SLITRK2_uc011mwr.1_Missense_Mutation_p.E567Q|SLITRK2_uc011mws.1_Missense_Mutation_p.E567Q|SLITRK2_uc004fcg.2_Missense_Mutation_p.E567Q|SLITRK2_uc011mwt.1_Missense_Mutation_p.E567Q	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	567	Extracellular (Potential).|LRRCT 2.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					GCATGCAGGGGAGATACTAAA	0.478000												
MTMR1	8776	broad.mit.edu	37	X	149905805	149905805	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:149905805C>T	uc004fei.2	+	11	1469	c.1334C>T	c.(1333-1335)ACA>ATA	p.T445I	MTMR1_uc011mya.1_Missense_Mutation_p.T351I|MTMR1_uc004feh.1_Missense_Mutation_p.T453I|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	445	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TGGGACCGAACAGCCCAGCTC	0.453000												
ATP2B3	492	broad.mit.edu	37	X	152845624	152845624	+	Silent	SNP	G	G	A			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chrX:152845624G>A	uc004fht.1	+	20	3657	c.3531G>A	c.(3529-3531)CCG>CCA	p.P1177P	ATP2B3_uc004fhs.1_3'UTR|ATP2B3_uc010nuf.1_Silent_p.P314P|ATP2B3_uc004fhu.1_Silent_p.P129P	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	1177	Cytoplasmic (Potential).|Poly-Pro.				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCCGCCCCCGTCCCCCAACC	0.602000												
FOXD4	2298	broad.mit.edu	37	9	117413	117414	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-8296-01A-11D-2340-08	TCGA-BR-8296-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64c0f192-0cd5-4a42-98e9-da539ffbdb8e	97c72465-c307-4e73-8a74-9d5c6da3680e	g.chr9:117412_117413A>AG	uc003zfz.3	-	0	1005_1006	c.707_708T>CT	c.(706-708)cctfs	p.P236fs		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	Homo sapiens forkhead box D4 (FOXD4), mRNA.	236	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCGGCGGGGCAGGGGCCCCAAG	0.728