Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
S100PBP	64766	broad.mit.edu	37	1	33318765	33318765	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:33318765G>A	uc001bvz.2	+	6	1387	c.1110G>A	c.(1108-1110)ACG>ACA	p.T370T	S100PBP_uc001bwc.2_Silent_p.T370T|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	370						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				ACCTCACCACGCGGTGAGTGG	0.348000												
MACF1	23499	broad.mit.edu	37	1	39776014	39776014	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:39776014T>G	uc010ois.1	+	26	3234	c.3029T>G	c.(3028-3030)TTC>TGC	p.F1010C	MACF1_uc001cda.1_Missense_Mutation_p.F918C|MACF1_uc001cdc.1_Missense_Mutation_p.F97C|MACF1_uc009vvq.1_Missense_Mutation_p.F67C|MACF1_uc001cdb.1_Missense_Mutation_p.F97C	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1010					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCTGTGCTGTTCTCAGTGGCT	0.527000												
GTF2B	2959	broad.mit.edu	37	1	89329732	89329732	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:89329732G>C	uc001dmo.3	-	3	309	c.190C>G	c.(190-192)CCA>GCA	p.P64A	GTF2B_uc009wcw.1_Intron	NM_001514	NP_001505	Q00403	TF2B_HUMAN	general transcription factor IIB	64					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		ACTCGAGATGGATCTTTTGTT	0.398000												
POGZ	23126	broad.mit.edu	37	1	151413529	151413529	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:151413529A>T	uc001eyd.1	-	3	464	c.158T>A	c.(157-159)GTG>GAG	p.V53E	POGZ_uc001eye.1_Intron|POGZ_uc010pdb.1_Missense_Mutation_p.V53E|POGZ_uc001eyf.1_Intron|POGZ_uc010pdc.1_Intron|POGZ_uc009wmv.1_Missense_Mutation_p.V53E|POGZ_uc010pdd.1_Intron|POGZ_uc001eyg.1_Missense_Mutation_p.V53E	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	53					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGCGATGGGCACTGGAGCCGA	0.547000												
S100A7L2	645922	broad.mit.edu	37	1	153410796	153410796	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:153410796G>A	uc010pdx.1	-	2	121	c.43C>T	c.(43-45)CCT>TCT	p.P15S		NM_001045479	NP_001038944			S100 calcium binding protein A7-like 2											ovary(1)	1	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCACCTAGAGGGATATTCATC	0.398000												
APOA2	336	broad.mit.edu	37	1	161192255	161192255	+	Silent	SNP	C	C	T	rs138452270		TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:161192255C>T	uc001fzc.1	-	4	301	c.243G>A	c.(241-243)ACG>ACA	p.T81T	APOA2_uc001fzb.1_RNA	NM_001643	NP_001634	P02652	APOA2_HUMAN	apolipoprotein A-II preproprotein	81					cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			skin(1)	1	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TAACCAGTTCCGTTCCAGCCT	0.498000												
ATP1B1	481	broad.mit.edu	37	1	169099314	169099314	+	RNA	SNP	C	C	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:169099314C>A	uc001gfs.1	+	5		c.759C>A						P05026	AT1B1_HUMAN	Synthetic construct DNA, clone: pF1KB8186, Homo sapiens ATP1B1 gene for ATPase, Na+/K+ transporting, beta 1 polypeptide, without stop codon, in Flexi system.						ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	all_hematologic(923;0.208)					CCTTCCCGTTCAGTGCACTGG	0.443000												
CACNA1E	777	broad.mit.edu	37	1	181546939	181546939	+	Missense_Mutation	SNP	G	G	A	rs140645319	by1000genomes	TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:181546939G>A	uc001gow.2	+	4	715	c.550G>A	c.(550-552)GTG>ATG	p.V184M	CACNA1E_uc009wxr.2_Missense_Mutation_p.V91M|CACNA1E_uc009wxs.2_Missense_Mutation_p.V91M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	184	I.|Extracellular (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CAATACTCACGTGGACCTGAG	0.547000												
SLC26A9	115019	broad.mit.edu	37	1	205901913	205901913	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:205901913A>T	uc001hdq.2	-	4	407	c.293T>A	c.(292-294)CTT>CAT	p.L98H	SLC26A9_uc001hdp.2_Missense_Mutation_p.L98H	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	98	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GACTGCAGGAAGGTTGGCCAG	0.572000												
TRAF3IP3	80342	broad.mit.edu	37	1	209933473	209933473	+	Missense_Mutation	SNP	G	G	A	rs142003331	byFrequency	TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:209933473G>A	uc001hho.2	+	3	379	c.89G>A	c.(88-90)CGT>CAT	p.R30H	TRAF3IP3_uc001hhl.2_Missense_Mutation_p.R30H|TRAF3IP3_uc001hhm.1_Missense_Mutation_p.R30H|TRAF3IP3_uc001hhn.2_Missense_Mutation_p.R30H|TRAF3IP3_uc009xcr.2_Missense_Mutation_p.R30H	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	30	Cytoplasmic (Potential).					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		CAAGAGATCCGTGAAAGCCGC	0.627000												
ARID4B	51742	broad.mit.edu	37	1	235377337	235377337	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:235377337C>T	uc001hwq.2	-	17	2086	c.1588G>A	c.(1588-1590)GAA>AAA	p.E530K	ARID4B_uc001hwr.2_Intron|ARID4B_uc001hws.3_Intron|ARID4B_uc001hwt.3_Missense_Mutation_p.E211K	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	530	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			tTATTCGTTTCATCTCTTGAA	0.189000												
TRDMT1	1787	broad.mit.edu	37	10	17216575	17216575	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr10:17216575G>T	uc001iop.2	-	2	197	c.149C>A	c.(148-150)ACA>AAA	p.T50K	TRDMT1_uc001ioq.2_Missense_Mutation_p.T50K|TRDMT1_uc001ior.2_Missense_Mutation_p.T50K|TRDMT1_uc001ios.2_5'UTR|TRDMT1_uc009xjt.2_Missense_Mutation_p.H17N|TRDMT1_uc010qcd.1_Missense_Mutation_p.T50K|TRDMT1_uc009xjs.1_Missense_Mutation_p.H17N|TRDMT1_uc009xju.1_RNA	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform	50					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						AAGTAACTGTGTGTGAGGAAA	0.368000												
AIFM2	84883	broad.mit.edu	37	10	71874730	71874730	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr10:71874730C>T	uc010qjg.1	-	7	929	c.916G>A	c.(916-918)GTG>ATG	p.V306M	AIFM2_uc001jqp.1_Missense_Mutation_p.V306M	NM_032797	NP_116186	Q9BRQ8	AIFM2_HUMAN	apoptosis-inducing factor (AIF)-like	306					apoptotic mitochondrial changes|chromosome condensation|induction of apoptosis	cytosol|integral to membrane|mitochondrial outer membrane	DNA binding|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding			central_nervous_system(1)	1						ATGTTGGCCACGGCGATGTTG	0.592000												
EBF3	253738	broad.mit.edu	37	10	131665478	131665478	+	Silent	SNP	G	G	A	rs151206880		TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr10:131665478G>A	uc001lki.1	-	10	998	c.939C>T	c.(937-939)GGC>GGT	p.G313G		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	322	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CTTCGACGACGCCAGGAATGT	0.582000												
PHRF1	57661	broad.mit.edu	37	11	601629	601629	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:601629A>T	uc001lqe.2	+	10	1211	c.1080A>T	c.(1078-1080)AAA>AAT	p.K360N	PHRF1_uc010qwc.1_Missense_Mutation_p.K360N|PHRF1_uc010qwd.1_Missense_Mutation_p.K359N|PHRF1_uc010qwe.1_Missense_Mutation_p.K356N|PHRF1_uc009ybz.1_Missense_Mutation_p.K151N	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	360	Arg-rich.						RNA polymerase binding|zinc ion binding				0						CATCCGCAAAAAGTAAGAGCT	0.512000												
TALDO1	6888	broad.mit.edu	37	11	760142	760142	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:760142C>T	uc001lqz.2	+	4	400	c.350C>T	c.(349-351)GCG>GTG	p.A117V	TALDO1_uc010qwl.1_Missense_Mutation_p.A117V|TALDO1_uc001lra.2_Missense_Mutation_p.A117V	NM_006755	NP_006746	P37837	TALDO_HUMAN	transaldolase 1	117					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		GATAAAGATGCGATGGTGGCC	0.547000												
C11orf41	25758	broad.mit.edu	37	11	33564658	33564658	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:33564658C>T	uc001mup.3	+	1	782	c.658C>T	c.(658-660)CCA>TCA	p.P220S	C11orf41_uc001mun.1_Missense_Mutation_p.P220S	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	220						integral to membrane				ovary(2)	2						TCATGCCTCCCCATCTCCTGT	0.547000											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
GLYAT	10249	broad.mit.edu	37	11	58477426	58477426	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:58477426G>A	uc001nnb.2	-	6	859	c.704C>T	c.(703-705)CCG>CTG	p.P235L		NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	235					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	CCGGTATTCCGGCAAGGTGCC	0.547000												
MARK2	2011	broad.mit.edu	37	11	63666571	63666571	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:63666571A>C	uc001nxw.2	+	7	1101	c.522A>C	c.(520-522)AGA>AGC	p.R174S	MARK2_uc001nxx.2_Missense_Mutation_p.R174S|MARK2_uc001nxy.2_Missense_Mutation_p.R174S|MARK2_uc001nxv.3_Missense_Mutation_p.R174S|MARK2_uc001nxz.3_Missense_Mutation_p.R141S|MARK2_uc009yoy.2_Missense_Mutation_p.R141S	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	174	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						TTGTCCATAGAGACTTAAAGG	0.493000												
EFEMP2	30008	broad.mit.edu	37	11	65635413	65635413	+	Missense_Mutation	SNP	G	G	C	rs150435989		TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:65635413G>C	uc001ofy.3	-	10	1283	c.1089C>G	c.(1087-1089)ATC>ATG	p.I363M	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.I363M	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	363					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		AGGTCGCCTGGATCTGGAACA	0.577000												
EFEMP2	30008	broad.mit.edu	37	11	65635426	65635426	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:65635426T>C	uc001ofy.3	-	10	1270	c.1076A>G	c.(1075-1077)GAC>GGC	p.D359G	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.D359G	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	359					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		CTGGAACACGTCAGCGGGCAC	0.592000												
PC	5091	broad.mit.edu	37	11	66639309	66639309	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:66639309G>A	uc001ojn.1	-	3	219	c.170C>T	c.(169-171)ACG>ATG	p.T57M	PC_uc001ojo.1_Missense_Mutation_p.T57M|PC_uc001ojp.1_Missense_Mutation_p.T57M	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	57	Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GCCCAGCTCCGTGCAGGCCCG	0.577000												
KCNE3	10008	broad.mit.edu	37	11	74168442	74168442	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:74168442T>A	uc001ovc.2	-	3	514	c.167A>T	c.(166-168)AAC>ATC	p.N56I	KCNE3_uc001ovd.2_Missense_Mutation_p.N56I	NM_005472	NP_005463	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related	56						integral to membrane	voltage-gated potassium channel activity			ovary(1)	1	Breast(11;2.86e-06)					CATGTAGGAGTTGTCATCACG	0.562000												
PCF11	51585	broad.mit.edu	37	11	82879823	82879823	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:82879823G>T	uc001ozx.3	+	8	2791	c.2446G>T	c.(2446-2448)GGG>TGG	p.G816W	PCF11_uc010rsu.1_Missense_Mutation_p.G947W	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	816	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GCTAGGAGGTGGGTGTCCTTT	0.562000												
KIAA1377	57562	broad.mit.edu	37	11	101849101	101849101	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:101849101C>T	uc001pgm.2	+	7	3139	c.2869C>T	c.(2869-2871)CGA>TGA	p.R957*	KIAA1377_uc001pgn.2_Nonsense_Mutation_p.R913*|KIAA1377_uc010run.1_Nonsense_Mutation_p.R758*	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	957							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAGAAGAAAACGAATTGCTGA	0.353000												
CASP4	837	broad.mit.edu	37	11	104819260	104819260	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:104819260G>A	uc001pid.1	-	6	998	c.925C>T	c.(925-927)CAC>TAC	p.H309Y	CASP4_uc001pib.1_Missense_Mutation_p.H253Y|CASP4_uc009yxg.1_Missense_Mutation_p.H218Y	NM_001225	NP_001216	P49662	CASP4_HUMAN	caspase 4 isoform alpha precursor	309					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			lung(2)|ovary(1)|skin(1)	4		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		AGATACATACGTGGCGTTGAA	0.443000												
TMPRSS13	84000	broad.mit.edu	37	11	117780642	117780642	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:117780642C>T	uc001prs.1	-	8	1081	c.988G>A	c.(988-990)GCG>ACG	p.A330T	TMPRSS13_uc009yzr.1_Missense_Mutation_p.A9T|TMPRSS13_uc001prt.1_Missense_Mutation_p.A9T|TMPRSS13_uc001pru.1_Missense_Mutation_p.A330T	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	325	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			pancreas(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GAGGCCAGCGCCCCTCCCACG	0.617000												
C11orf63	79864	broad.mit.edu	37	11	122817220	122817220	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:122817220C>G	uc001pym.2	+	6	1946	c.1649C>G	c.(1648-1650)TCT>TGT	p.S550C		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	550										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		TTCCATTCTTCTTCTGACAGC	0.403000												
TMEM45B	120224	broad.mit.edu	37	11	129725628	129725628	+	Silent	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr11:129725628C>T	uc001qfe.1	+	4	472	c.411C>T	c.(409-411)CAC>CAT	p.H137H	TMEM45B_uc001qff.1_Silent_p.H137H	NM_138788	NP_620143	Q96B21	TM45B_HUMAN	transmembrane protein 45B	137						integral to membrane					0	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		ACCACGTCCACAACCGGCCTC	0.552000												
OR6C75	390323	broad.mit.edu	37	12	55759444	55759444	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr12:55759444C>A	uc010spk.1	+	1	550	c.550C>A	c.(550-552)CAG>AAG	p.Q184K		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						TCCAATGCTGCAGCTCTCTTG	0.408000												
CNOT2	4848	broad.mit.edu	37	12	70704765	70704765	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr12:70704765T>C	uc001svv.2	+	3	718	c.139T>C	c.(139-141)TCT>CCT	p.S47P	CNOT2_uc009zro.2_Missense_Mutation_p.S47P|CNOT2_uc009zrp.2_Missense_Mutation_p.S27P|CNOT2_uc009zrq.2_Missense_Mutation_p.S47P	NM_014515	NP_055330	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	47					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity				0	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			CTACAGCCAGTCTTCTATGTT	0.388000												
MYBPC1	4604	broad.mit.edu	37	12	102010978	102010978	+	Splice_Site	SNP	A	A	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr12:102010978A>C	uc001tii.2	+	3	164	c.62_splice	c.e3-2	p.E21_splice	MYBPC1_uc001tif.1_Splice_Site_p.E21_splice|MYBPC1_uc001tig.2_Splice_Site_p.E21_splice|MYBPC1_uc010svq.1_Intron|MYBPC1_uc001tih.2_Splice_Site_p.E21_splice|MYBPC1_uc001tij.2_Splice_Site_p.E21_splice|MYBPC1_uc010svr.1_Splice_Site_p.E21_splice|MYBPC1_uc010svs.1_Splice_Site_p.E21_splice|MYBPC1_uc010svt.1_Splice_Site_p.E9_splice|MYBPC1_uc010svu.1_Splice_Site_p.E21_splice|MYBPC1_uc001tik.2_Intron	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3						cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						CTTTCTACACAGAACCAAGTA	0.433000												
SIAH3	283514	broad.mit.edu	37	13	46357872	46357872	+	Silent	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr13:46357872C>T	uc001vap.2	-	2	538	c.456G>A	c.(454-456)GCG>GCA	p.A152A		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	152					multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						AATCAGCCGGCGCGGGGAGGT	0.612000												
HAUS4	54930	broad.mit.edu	37	14	23415837	23415837	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr14:23415837A>G	uc001whp.2	-	9	1020	c.989T>C	c.(988-990)CTT>CCT	p.L330P	HAUS4_uc001who.2_RNA|HAUS4_uc001whq.2_Missense_Mutation_p.L204P|HAUS4_uc001whr.2_Missense_Mutation_p.L330P|HAUS4_uc001whs.2_Missense_Mutation_p.L285P|HAUS4_uc001wht.2_Missense_Mutation_p.L330P|HAUS4_uc001whu.2_Missense_Mutation_p.L285P|HAUS4_uc001whv.2_Missense_Mutation_p.L206P|HAUS4_uc001whw.2_Missense_Mutation_p.L330P|HAUS4_uc001whx.2_Missense_Mutation_p.L285P	NM_017815	NP_060285	Q9H6D7	HAUS4_HUMAN	HAUS augmin-like complex, subunit 4	330					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				ovary(1)	1						CTCCTCCCCAAGGACCTCATA	0.557000												
ACIN1	22985	broad.mit.edu	37	14	23532239	23532239	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr14:23532239T>G	uc001wit.3	-	14	3284	c.2956A>C	c.(2956-2958)AAG>CAG	p.K986Q	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.K228Q|ACIN1_uc001wiq.3_Missense_Mutation_p.K228Q|ACIN1_uc001wir.3_Missense_Mutation_p.K259Q|ACIN1_uc001wis.3_Missense_Mutation_p.K667Q|ACIN1_uc010akg.2_Missense_Mutation_p.K973Q	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	986					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ACTCCGGACTTCTGCTGGCTA	0.478000												
AKAP6	9472	broad.mit.edu	37	14	33290766	33290766	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr14:33290766G>A	uc001wrq.2	+	13	3917	c.3747G>A	c.(3745-3747)TTG>TTA	p.L1249L		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1249					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCCCTTCCTTGAAGCTTGGAG	0.438000												
SGPP1	81537	broad.mit.edu	37	14	64194098	64194098	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr14:64194098G>A	uc001xgj.2	-	1	659	c.565C>T	c.(565-567)CCG>TCG	p.P189S		NM_030791	NP_110418	Q9BX95	SGPP1_HUMAN	sphingosine-1-phosphate phosphatase 1	189						endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0056)|all cancers(60;0.0141)|BRCA - Breast invasive adenocarcinoma(234;0.103)		ACCACGGGCGGCGAGGCGGGC	0.632000												
SYNE2	23224	broad.mit.edu	37	14	64628976	64628976	+	Silent	SNP	A	A	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr14:64628976A>C	uc001xgm.2	+	88	16511	c.16281A>C	c.(16279-16281)CCA>CCC	p.P5427P	SYNE2_uc001xgl.2_Silent_p.P5427P|SYNE2_uc010apy.2_Silent_p.P1812P|SYNE2_uc001xgn.2_Silent_p.P389P|SYNE2_uc001xgo.2_RNA|SYNE2_uc001xgp.2_Silent_p.P156P|SYNE2_uc010aqa.2_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5427	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCCTGCCCCCAGCCCTGCAGG	0.547000												
KCNK13	56659	broad.mit.edu	37	14	90651236	90651236	+	Silent	SNP	C	C	T	rs112153420	byFrequency	TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr14:90651236C>T	uc001xye.1	+	2	1558	c.1116C>T	c.(1114-1116)AAC>AAT	p.N372N		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	372	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				AGATGGCCAACGGCTGCCCCC	0.597000												
FBLN5	10516	broad.mit.edu	37	14	92343836	92343836	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr14:92343836T>C	uc001xzx.3	-	10	1653	c.1180A>G	c.(1180-1182)ATG>GTG	p.M394V	FBLN5_uc010aud.2_Missense_Mutation_p.M399V|FBLN5_uc010aue.2_Missense_Mutation_p.M435V|FBLN5_uc001xzw.2_5'Flank	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	394					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				CTTACCCGCATGTAAAATTCT	0.537000												
SERPINA5	5104	broad.mit.edu	37	14	95056501	95056501	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr14:95056501G>A	uc001ydm.2	+	4	953	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	SERPINA5_uc010ave.2_Missense_Mutation_p.R248Q|SERPINA3_uc001ydo.3_5'Flank	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	248					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CTCCTGGACCGGAACCTCTCC	0.577000												
MKRN3	7681	broad.mit.edu	37	15	23811198	23811198	+	Missense_Mutation	SNP	G	G	A	rs140349866		TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr15:23811198G>A	uc001ywh.3	+	1	745	c.269G>A	c.(268-270)CGA>CAA	p.R90Q	MKRN3_uc001ywi.2_Missense_Mutation_p.R90Q|MKRN3_uc010ayi.1_Missense_Mutation_p.R90Q	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	90						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TTGCCAAGCCGAAGCAGCGGC	0.602000												
MKRN3	7681	broad.mit.edu	37	15	23811962	23811962	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr15:23811962C>T	uc001ywh.3	+	1	1509	c.1033C>T	c.(1033-1035)CGC>TGC	p.R345C	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.R345C	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	345	RING-type.					ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TAGGTGTATCCGCAGGTGGAG	0.507000												
GJD2	57369	broad.mit.edu	37	15	35045438	35045438	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr15:35045438G>A	uc001zis.1	-	2	207	c.207C>T	c.(205-207)CGC>CGT	p.R69R	uc001zit.1_5'Flank	NM_020660	NP_065711	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	69	Extracellular (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		TGGGGAAGGCGCGGTCATAGC	0.552000												
DNAJC17	55192	broad.mit.edu	37	15	41067260	41067260	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr15:41067260G>C	uc001zms.1	-	8	580	c.569C>G	c.(568-570)TCC>TGC	p.S190C	DNAJC17_uc010bbz.1_RNA|DNAJC17_uc010bca.1_RNA|DNAJC17_uc010bcb.1_RNA	NM_018163	NP_060633	Q9NVM6	DJC17_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 17	190	RRM.				protein folding		heat shock protein binding|nucleotide binding|RNA binding|unfolded protein binding				0		all_cancers(109;4.16e-14)|all_epithelial(112;9.68e-12)|Lung NSC(122;3.19e-09)|all_lung(180;6.45e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		GACGTCTTTGGAGTAGCCACC	0.502000												
KIAA1199	57214	broad.mit.edu	37	15	81230194	81230194	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr15:81230194C>T	uc002bfw.1	+	24	3541	c.3281C>T	c.(3280-3282)TCG>TTG	p.S1094L	KIAA1199_uc010unn.1_Missense_Mutation_p.S1094L	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	1094										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TCCATCCTCTCGGATGTTCAC	0.577000												
IQGAP1	8826	broad.mit.edu	37	15	91037964	91037964	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr15:91037964G>A	uc002bpl.1	+	36	4749	c.4648G>A	c.(4648-4650)GAA>AAA	p.E1550K	IQGAP1_uc010uqg.1_Missense_Mutation_p.E171K	NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1550	C2.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AAAGCCTAGGGAAATGAAAGG	0.358000												
ST8SIA2	8128	broad.mit.edu	37	15	93007503	93007503	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr15:93007503A>G	uc002bra.2	+	6	1171	c.1016A>G	c.(1015-1017)TAC>TGC	p.Y339C	ST8SIA2_uc002brb.2_Missense_Mutation_p.Y318C	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	339	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			AAGTATGGCTACACCTCCCAG	0.532000												
MSLNL	401827	broad.mit.edu	37	16	820288	820288	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr16:820288G>A	uc002cjz.1	-	15	2697	c.2697C>T	c.(2695-2697)AGC>AGT	p.S899S		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	548	Extracellular (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						CAACATCCAGGCTCTGCGGAG	0.692000												
ABCC6	368	broad.mit.edu	37	16	16255323	16255325	+	Missense_Mutation	TNP	ACG	ACG	CGA			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr16:16255323_16255325ACG>CGA	uc002den.3	-	25	3640_3642	c.3603_3605CGT>TCG	c.(3601-3606)CTCGTG>CTTCGG	p.V1202R	ABCC6_uc010bvo.2_RNA	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	1202	ABC transmembrane type-1 2.|Helical; Name=17; (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		AGAGAAGCCCACGAGGCCAGCAC	0.626000												
RBBP6	5930	broad.mit.edu	37	16	24581590	24581590	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr16:24581590G>A	uc002dmh.2	+	17	4619	c.3579G>A	c.(3577-3579)AGG>AGA	p.R1193R	RBBP6_uc010vcb.1_Silent_p.R1060R|RBBP6_uc002dmi.2_Silent_p.R1159R|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Silent_p.R1026R	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1193					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		AAATGGATAGGACCCCTGAAA	0.358000												
KLHL36	79786	broad.mit.edu	37	16	84693458	84693458	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr16:84693458G>A	uc002fig.2	+	4	1371	c.1230G>A	c.(1228-1230)GCG>GCA	p.A410A	KLHL36_uc010chl.2_Intron	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	410	Kelch 3.									skin(2)	2						AGAACGGAGCGCTCTCTTCAG	0.582000												
TP53	7157	broad.mit.edu	37	17	7577094	7577094	+	Missense_Mutation	SNP	G	G	A	rs28934574		TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr17:7577094G>A	uc002gim.2	-	8	1038	c.844C>T	c.(844-846)CGG>TGG	p.R282W	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R282W|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R150W|TP53_uc010cng.1_Missense_Mutation_p.R150W|TP53_uc002gii.1_Missense_Mutation_p.R150W|TP53_uc010cnh.1_Missense_Mutation_p.R282W|TP53_uc010cni.1_Missense_Mutation_p.R282W|TP53_uc002gij.2_Missense_Mutation_p.R282W	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	282	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|R -> Q (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R282W(367)|p.R282G(27)|p.R282Q(20)|p.R282P(14)|p.R282R(8)|p.0?(7)|p.R282L(3)|p.D281fs*63(2)|p.?(2)|p.R282fs*24(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.R280fs*62(1)|p.R282_E287delRRTEEE(1)|p.G279fs*59(1)|p.S269fs*21(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.R282H(1)|p.R283_T284>T(1)|p.V272_K292del21(1)|p.R282fs*63(1)|p.C275fs*20(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTGTGCGCCGGTCTCTCCCA	0.557000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
EFCAB5	374786	broad.mit.edu	37	17	28417544	28417544	+	Silent	SNP	G	G	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr17:28417544G>T	uc002het.2	+	20	3981	c.3789G>T	c.(3787-3789)CTG>CTT	p.L1263L	EFCAB5_uc010cse.2_Silent_p.L1018L|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1263							calcium ion binding			ovary(1)|skin(1)	2						GAGAGGCTCTGGGAGTCCTCG	0.428000												
KRTAP9-9	81870	broad.mit.edu	37	17	39411934	39411934	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr17:39411934C>A	uc010wfq.1	+	3	254	c.252C>A	c.(250-252)AGC>AGA	p.S84R		NM_030975	NP_112237	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	99						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GTGGGTCCAGCTGTGGCCAGA	0.612000												
IGF2BP1	10642	broad.mit.edu	37	17	47076502	47076502	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr17:47076502G>C	uc002iom.2	+	2	541	c.207G>C	c.(205-207)GAG>GAC	p.E69D	IGF2BP1_uc010dbj.2_Missense_Mutation_p.E69D	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	69	RRM 1.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						AACGCTTAGAGATTGAACATT	0.493000												
RNFT1	51136	broad.mit.edu	37	17	58040311	58040311	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr17:58040311C>T	uc002iya.2	-	2	484	c.391G>A	c.(391-393)GCA>ACA	p.A131T	uc002iye.1_5'Flank|RNFT1_uc002iyb.2_RNA|RNFT1_uc002iyc.2_5'UTR|RNFT1_uc010wop.1_Missense_Mutation_p.A131T|RNFT1_uc002iyd.3_Missense_Mutation_p.A131T	NM_016125	NP_057209	Q5M7Z0	RNFT1_HUMAN	PTD016 protein	131						integral to membrane	zinc ion binding				0	all_cancers(5;1.58e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;7.95e-12)|all cancers(12;1.34e-10)			CCAGATTCTGCGGCAGTATCA	0.463000												
AATK	9625	broad.mit.edu	37	17	79095615	79095615	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr17:79095615G>A	uc010dia.2	-	11	2201	c.2121C>T	c.(2119-2121)GGC>GGT	p.G707G	AATK_uc010dhz.2_RNA	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	707						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GACTGGGGCAGCCCTCAGCGT	0.706000												
CD97	976	broad.mit.edu	37	19	14517256	14517256	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr19:14517256C>G	uc002myl.2	+	15	2058	c.1935C>G	c.(1933-1935)TTC>TTG	p.F645L	CD97_uc002mym.2_Missense_Mutation_p.F596L|CD97_uc002myn.2_Missense_Mutation_p.F552L	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	645	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						TGCGCGTGTTCCAAGGCCAGG	0.647000											OREG0025312	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
ZNF536	9745	broad.mit.edu	37	19	30935864	30935864	+	Silent	SNP	G	G	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr19:30935864G>C	uc002nsu.1	+	2	1533	c.1395G>C	c.(1393-1395)GCG>GCC	p.A465A	ZNF536_uc010edd.1_Silent_p.A465A	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AGAAGGAAGCGCTGGGGAAGC	0.657000												
CYP2F1	1572	broad.mit.edu	37	19	41627980	41627980	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr19:41627980C>T	uc002opu.1	+	6	820	c.764C>T	c.(763-765)TCG>TTG	p.S255L	CYP2F1_uc010xvw.1_Missense_Mutation_p.S41L|CYP2F1_uc010xvv.1_Missense_Mutation_p.S255L|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	255					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						CACCAGGCCTCGCTAGACCCC	0.587000												
GPR32	2854	broad.mit.edu	37	19	51273919	51273919	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr19:51273919G>A	uc010ycf.1	+	1	62	c.62G>A	c.(61-63)CGT>CAT	p.R21H		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	21	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GTCCTGACACGTGATCGCTCT	0.522000												
VN1R2	317701	broad.mit.edu	37	19	53762763	53762763	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr19:53762763A>C	uc002qbi.2	+	1	1219	c.1135A>C	c.(1135-1137)AGT>CGT	p.S379R		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	379	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		CAGGCTCTGCAGTATCTGCTG	0.458000												
TNNT1	7138	broad.mit.edu	37	19	55645256	55645256	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr19:55645256A>C	uc002qjb.3	-	13	879	c.790T>G	c.(790-792)TTC>GTC	p.F264V	TNNT1_uc002qiz.3_Missense_Mutation_p.F178V|TNNT1_uc002qja.3_Missense_Mutation_p.F178V|TNNT1_uc002qjc.3_Missense_Mutation_p.F248V|TNNT1_uc002qje.3_Missense_Mutation_p.F237V|TNNT1_uc002qjd.3_Missense_Mutation_p.F237V	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	264					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CACACTCACAACTTCTGGGCG	0.632000												
PEG3	5178	broad.mit.edu	37	19	57326272	57326272	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr19:57326272C>T	uc002qnu.2	-	7	3889	c.3538G>A	c.(3538-3540)GAG>AAG	p.E1180K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E1151K|PEG3_uc002qnv.2_Missense_Mutation_p.E1180K|PEG3_uc002qnw.2_Missense_Mutation_p.E1056K|PEG3_uc002qnx.2_Missense_Mutation_p.E1054K|PEG3_uc010etr.2_Missense_Mutation_p.E1180K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1180	C2H2-type 7.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTCTGATGCTCGAAAAGGAAT	0.458000												
PNPT1	87178	broad.mit.edu	37	2	55874501	55874501	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr2:55874501C>T	uc002rzf.2	-	19	1636	c.1583G>A	c.(1582-1584)CGT>CAT	p.R528H	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	528					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGTCAGCAAACGATAATCTTC	0.289000												
RETSAT	54884	broad.mit.edu	37	2	85571127	85571127	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr2:85571127C>A	uc002spd.2	-	9	1719	c.1528G>T	c.(1528-1530)GGG>TGG	p.G510W	RETSAT_uc010fge.2_Intron|RETSAT_uc010ysm.1_Missense_Mutation_p.G449W|RETSAT_uc010fgf.2_Missense_Mutation_p.G301W	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	510					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	CCTACCTTCCCCTCCAGCTGT	0.542000												
NEB	4703	broad.mit.edu	37	2	152483704	152483704	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr2:152483704C>G	uc010fnx.2	-	66	9621	c.9430G>C	c.(9430-9432)GAT>CAT	p.D3144H		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3144	Nebulin 85.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		CACTGGAGATCAGATTTGTAA	0.393000												
LRP2	4036	broad.mit.edu	37	2	170072858	170072858	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr2:170072858T>C	uc002ues.2	-	35	5944	c.5731A>G	c.(5731-5733)AAA>GAA	p.K1911E		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1911	LDL-receptor class B 17.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AAGAGAGTTTTCACAGATGTG	0.493000												
DNAH7	56171	broad.mit.edu	37	2	196729342	196729342	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr2:196729342C>G	uc002utj.3	-	41	7138	c.7037G>C	c.(7036-7038)GGA>GCA	p.G2346A		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2346	ATP (Potential).|AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGACTGCCTTCCACTCCCTCC	0.473000												
CCNYL1	151195	broad.mit.edu	37	2	208611776	208611776	+	Silent	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr2:208611776C>T	uc002vci.2	+	6	849	c.492C>T	c.(490-492)TAC>TAT	p.Y164Y	CCNYL1_uc002vch.2_Silent_p.Y145Y	NM_001142300	NP_001135772	Q8N7R7	CCYL1_HUMAN	cyclin Y-like 1 isoform 1	215	Cyclin N-terminal.				regulation of cyclin-dependent protein kinase activity		protein kinase binding				0				LUSC - Lung squamous cell carcinoma(261;0.0731)|Epithelial(149;0.139)|Lung(261;0.14)		TACAGGTTTACTTAGAAAGGC	0.318000												
SIRPD	128646	broad.mit.edu	37	20	1517875	1517875	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr20:1517875G>A	uc002wfi.2	-	3	547	c.503C>T	c.(502-504)TCG>TTG	p.S168L		NM_178460	NP_848555	Q9H106	SIRPD_HUMAN	signal-regulatory protein delta precursor	168						extracellular region				ovary(1)|kidney(1)|skin(1)	3						AGGCAGGGCCGAGAGGCAGGT	0.597000												
PTPN1	5770	broad.mit.edu	37	20	49197803	49197803	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr20:49197803A>G	uc002xvl.2	+	9	1264	c.1090A>G	c.(1090-1092)ATG>GTG	p.M364V	PTPN1_uc010zys.1_Missense_Mutation_p.M291V	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	364					blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	ATTCCTCAGCATGAGTCAAGA	0.532000												
DIDO1	11083	broad.mit.edu	37	20	61542508	61542508	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr20:61542508C>T	uc002ydr.1	-	3	721	c.457G>A	c.(457-459)GAT>AAT	p.D153N	DIDO1_uc002yds.1_Missense_Mutation_p.D153N|DIDO1_uc002ydt.1_Missense_Mutation_p.D153N|DIDO1_uc002ydu.1_Missense_Mutation_p.D153N|DIDO1_uc002ydv.1_Missense_Mutation_p.D153N|DIDO1_uc002ydw.1_Missense_Mutation_p.D153N|DIDO1_uc002ydx.1_Missense_Mutation_p.D153N|DIDO1_uc011aao.1_Missense_Mutation_p.D153N	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	153					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTGTCACTATCGGAGGTGTCA	0.572000												
KCNQ2	3785	broad.mit.edu	37	20	62046361	62046361	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr20:62046361C>G	uc002yey.1	-	13	1597	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	KCNQ2_uc002yez.1_Missense_Mutation_p.E444Q|KCNQ2_uc002yfa.1_Missense_Mutation_p.E456Q|KCNQ2_uc002yfb.1_Missense_Mutation_p.E446Q	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	474	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GGGCTGTCCTCGAGGCTCTGG	0.692000												
NCAM2	4685	broad.mit.edu	37	21	22656515	22656515	+	Silent	SNP	G	G	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr21:22656515G>T	uc002yld.1	+	3	381	c.132G>T	c.(130-132)GCG>GCT	p.A44A	NCAM2_uc011acb.1_Intron|NCAM2_uc011acc.1_Silent_p.A69A	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	44	Ig-like C2-type 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TCTTTGCAGCGATTGGTGAAC	0.328000												
CSF2RB	1439	broad.mit.edu	37	22	37328890	37328890	+	Missense_Mutation	SNP	G	G	A	rs146404001	by1000genomes	TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr22:37328890G>A	uc003aqa.3	+	9	1313	c.1096G>A	c.(1096-1098)GAA>AAA	p.E366K	CSF2RB_uc003aqc.3_Missense_Mutation_p.E372K	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	366	Extracellular (Potential).|Fibronectin type-III 2.				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	AATGCGATACGAACACATAGA	0.567000												
ADSL	158	broad.mit.edu	37	22	40754925	40754925	+	Silent	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr22:40754925C>T	uc003ayp.3	+	5	599	c.540C>T	c.(538-540)TGC>TGT	p.C180C	ADSL_uc003ays.3_Silent_p.C180C|ADSL_uc003ayq.3_Silent_p.C180C|ADSL_uc003ayr.3_5'UTR|ADSL_uc003ayt.3_Silent_p.C165C|ADSL_uc010gyb.1_RNA	NM_000026	NP_000017	P30566	PUR8_HUMAN	adenylosuccinate lyase isoform a	180					AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			ovary(1)	1						AGGATCTTTGCATGGATCTCC	0.532000												
PLXNB2	23654	broad.mit.edu	37	22	50717049	50717049	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr22:50717049G>A	uc003bkv.3	-	29	4729	c.4623C>T	c.(4621-4623)CGC>CGT	p.R1541R	PLXNB2_uc003bkt.1_Silent_p.R333R|PLXNB2_uc003bku.1_Silent_p.R526R	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1541	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGGTGTTGACGCGCTTCCACC	0.667000												
GMPS	8833	broad.mit.edu	37	3	155649637	155649637	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr3:155649637G>C	uc003faq.2	+	13	1979	c.1644G>C	c.(1642-1644)AGG>AGC	p.R548S	GMPS_uc011bom.1_Missense_Mutation_p.R449S	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	548					glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TTCTGGCTAGGCTTATACCTC	0.428000			T	MLL	AML							
CRIPAK	285464	broad.mit.edu	37	4	1388392	1388392	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr4:1388392G>A	uc003gdf.2	+	1	3053	c.93G>A	c.(91-93)GAG>GAA	p.E31E		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	31					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CCCATGTGGAGTGCCCGCCTG	0.622000												
FAM53A	152877	broad.mit.edu	37	4	1657119	1657119	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr4:1657119G>A	uc011bve.1	-	4	666	c.468C>T	c.(466-468)GGC>GGT	p.G156G	FAM53A_uc010ibw.2_Silent_p.G156G	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	156						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			TGGCACTCCCGCCGCTGTCGC	0.736000												
PI4K2B	55300	broad.mit.edu	37	4	25256828	25256828	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr4:25256828G>A	uc003grk.2	+	3	698	c.565G>A	c.(565-567)GAA>AAA	p.E189K	PI4K2B_uc011bxs.1_Missense_Mutation_p.E93K	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	189	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)				GTACCTTTCCGAAGCGGGTGC	0.443000												
CDH9	1007	broad.mit.edu	37	5	26903778	26903778	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:26903778C>A	uc003jgs.1	-	6	1136	c.967G>T	c.(967-969)GAT>TAT	p.D323Y	CDH9_uc010iug.2_Missense_Mutation_p.D323Y	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	323	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TCCTGTGTATCCTTGTCAGTG	0.403000												
RXFP3	51289	broad.mit.edu	37	5	33937437	33937437	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:33937437C>T	uc003jic.1	+	1	949	c.592C>T	c.(592-594)CGG>TGG	p.R198W		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	198	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						AGGACACGGCCGGGGCGACTG	0.672000												
AGXT2	64902	broad.mit.edu	37	5	35035360	35035360	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:35035360G>A	uc003jjf.2	-	5	627	c.548C>T	c.(547-549)GCG>GTG	p.A183V	AGXT2_uc011com.1_Missense_Mutation_p.A183V|AGXT2_uc011con.1_Missense_Mutation_p.A91V	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	183					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GTTTGAGTGCGCCCTGGCCAT	0.433000												
SPEF2	79925	broad.mit.edu	37	5	35806993	35806993	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:35806993G>A	uc003jjo.2	+	35	5306	c.5195G>A	c.(5194-5196)AGT>AAT	p.S1732N	SPEF2_uc003jjp.1_Missense_Mutation_p.S1218N|SPEF2_uc003jjr.2_Missense_Mutation_p.S787N	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1732					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAAGGGGGAAGTGAAGCACAG	0.393000												
UGT3A2	167127	broad.mit.edu	37	5	36037997	36037997	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:36037997G>A	uc003jjz.1	-	6	1290	c.1197C>T	c.(1195-1197)GTC>GTT	p.V399V	UGT3A2_uc011cos.1_Silent_p.V365V|UGT3A2_uc011cot.1_Silent_p.V97V	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	399	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTTCTACTCGGACCATGTTTT	0.478000												
CDC20B	166979	broad.mit.edu	37	5	54415675	54415675	+	Silent	SNP	C	C	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:54415675C>A	uc003jpo.1	-	11	1588	c.1413G>T	c.(1411-1413)GTG>GTT	p.V471V	CDC20B_uc003jpn.1_Silent_p.V471V|CDC20B_uc010ivu.1_Silent_p.V429V	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	471	WD 6.										0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			TCCACACAGTCACATCATTCT	0.423000												
ZNF366	167465	broad.mit.edu	37	5	71757315	71757315	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:71757315C>G	uc003kce.1	-	2	195	c.9G>C	c.(7-9)AAG>AAC	p.K3N		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		TCTTCATTTCCTTCTGCATCC	0.423000												
GPR98	84059	broad.mit.edu	37	5	90024493	90024493	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:90024493G>A	uc003kju.2	+	49	10265	c.10169G>A	c.(10168-10170)AGG>AAG	p.R3390K	GPR98_uc003kjt.2_Missense_Mutation_p.R1096K|GPR98_uc003kjv.2_Missense_Mutation_p.R990K	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3390	Extracellular (Potential).|EAR 3.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CAGGTCTTCAGGTGGAATGGA	0.433000												
FER	2241	broad.mit.edu	37	5	108134020	108134020	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:108134020T>A	uc003kop.1	+	3	521	c.137T>A	c.(136-138)TTA>TAA	p.L46*	FER_uc011cve.1_Intron|FER_uc011cvf.1_RNA|FER_uc003koq.2_Nonsense_Mutation_p.L46*|FER_uc011cvg.1_5'UTR	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	46	Important for interaction with membranes containing phosphoinositides.|FCH.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GCATCTACTTTACAGAACCTT	0.328000												
PCDHA11	56138	broad.mit.edu	37	5	140250469	140250469	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:140250469G>A	uc003lia.2	+	1	2639	c.1781G>A	c.(1780-1782)CGC>CAC	p.R594H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R594H	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	594	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAAGGTGCGCGCAGTGGAT	0.687000												
UIMC1	51720	broad.mit.edu	37	5	176395935	176395936	+	Missense_Mutation	DNP	AC	AC	CT			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr5:176395935_176395936AC>CT	uc011dfp.1	-	6	987_988	c.820_821GT>AG	c.(820-822)GTG>AGG	p.V274R	UIMC1_uc003mfc.1_Missense_Mutation_p.V151R|UIMC1_uc003mfd.1_Intron|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mff.1_Intron	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	274	AIR.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAAATAGTTCACAGTGCCCCCA	0.505000												
CDYL	9425	broad.mit.edu	37	6	4937947	4937947	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr6:4937947G>T	uc003mwi.2	+	6	1390	c.1259G>T	c.(1258-1260)AGC>ATC	p.S420I	CDYL_uc003mwj.2_Missense_Mutation_p.S366I|CDYL_uc003mwk.2_Missense_Mutation_p.S131I|CDYL_uc011dhx.1_Missense_Mutation_p.S234I|CDYL_uc011dhy.1_Missense_Mutation_p.S234I	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	420					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		AAAAGAGAAAGCACTAAAATG	0.403000												
DNAH8	1769	broad.mit.edu	37	6	38840773	38840773	+	Silent	SNP	G	G	T	rs114719419		TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr6:38840773G>T	uc003ooe.1	+	49	7278	c.6678G>T	c.(6676-6678)ACG>ACT	p.T2226T		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8									p.T2226M(1)		skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAACTCTGACGTTAGCTAATG	0.428000												
SNAP91	9892	broad.mit.edu	37	6	84371281	84371281	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr6:84371281A>C	uc011dze.1	-	5	709	c.392T>G	c.(391-393)TTG>TGG	p.L131W	SNAP91_uc003pkb.2_Missense_Mutation_p.L96W|SNAP91_uc003pkc.2_Missense_Mutation_p.L131W|SNAP91_uc003pkd.2_Missense_Mutation_p.L131W|SNAP91_uc003pka.2_Missense_Mutation_p.L131W|SNAP91_uc011dzf.1_Missense_Mutation_p.L12W	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	131	ENTH.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		CTTTTCATTCAAATATCTACT	0.328000												
NCOA7	135112	broad.mit.edu	37	6	126176272	126176272	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr6:126176272G>C	uc010kes.2	+	5	606	c.157G>C	c.(157-159)GAC>CAC	p.D53H	NCOA7_uc003qae.3_Missense_Mutation_p.D53H|NCOA7_uc003qah.2_Missense_Mutation_p.D53H|NCOA7_uc003qai.2_Missense_Mutation_p.D53H|NCOA7_uc010ket.2_Intron|NCOA7_uc003qaf.2_Missense_Mutation_p.D53H|NCOA7_uc003qag.2_Missense_Mutation_p.D53H|NCOA7_uc003qaj.2_Missense_Mutation_p.D53H	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	53					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		TTTAGAGCCAGACAAGTGCAA	0.378000												
INMT	11185	broad.mit.edu	37	7	30795204	30795204	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr7:30795204C>T	uc003tbs.1	+	3	545	c.529C>T	c.(529-531)CGC>TGC	p.R177C	FAM188B_uc010kwe.2_Intron|INMT_uc010kwc.1_RNA|INMT_uc010kwd.1_Missense_Mutation_p.R176C	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	177						cytoplasm	amine N-methyltransferase activity				0						TGATGCCTACCGCGCTGCCCT	0.657000												
GCK	2645	broad.mit.edu	37	7	44191983	44191983	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr7:44191983A>C	uc003tkl.2	-	3	720	c.250T>G	c.(250-252)TTC>GTC	p.F84V	GCK_uc003tkj.1_Missense_Mutation_p.F83V|GCK_uc003tkk.1_Missense_Mutation_p.F85V	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	84					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						ATCACCCTGAAGTTAGTGCCA	0.597000												
PON2	5445	broad.mit.edu	37	7	95035535	95035535	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr7:95035535C>G	uc003unv.2	-	8	923	c.802G>C	c.(802-804)GAT>CAT	p.D268H	PON2_uc003unu.2_Missense_Mutation_p.D256H|PON2_uc010lfk.2_RNA|PON2_uc003unw.2_Missense_Mutation_p.D181H	NM_000305	NP_000296	Q15165	PON2_HUMAN	paraoxonase 2 isoform 1	268		Calcium 1; catalytic (By similarity).			aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding				0	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			GATAAATTATCCACCAGTGTA	0.428000												
DUS4L	11062	broad.mit.edu	37	7	107214184	107214184	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr7:107214184G>A	uc003veh.2	+	5	607	c.274G>A	c.(274-276)GAT>AAT	p.D92N	DUS4L_uc003veg.2_Intron|DUS4L_uc011klw.1_Intron|DUS4L_uc011klx.1_5'UTR|DUS4L_uc010ljl.2_5'Flank	NM_181581	NP_853559	O95620	DUS4L_HUMAN	dihydrouridine synthase 4-like	92					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0						TGCTGCTAACGATGCAAGACT	0.403000												
CPA5	93979	broad.mit.edu	37	7	130008389	130008389	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr7:130008389G>T	uc010lmd.1	+	14	1882	c.1262G>T	c.(1261-1263)TGG>TTG	p.W421L	CPA5_uc003vps.2_Missense_Mutation_p.W421L|CPA5_uc003vpt.2_Nonsense_Mutation_p.G393*|CPA5_uc010lme.1_Missense_Mutation_p.W421L|CPA5_uc003vpu.1_Missense_Mutation_p.W421L|uc003vpv.1_RNA	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	421					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					CAGGAGACGTGGATGGCGCTT	0.607000												
CLCN1	1180	broad.mit.edu	37	7	143027909	143027909	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr7:143027909C>T	uc003wcr.1	+	8	985	c.898C>T	c.(898-900)CGG>TGG	p.R300W	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_RNA|CLCN1_uc010loy.1_Silent_p.F95F	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	300			R -> Q.		muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CTTTGCTGTTCGGAACTACTG	0.557000												
KCNH2	3757	broad.mit.edu	37	7	150648871	150648871	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr7:150648871C>T	uc003wic.2	-	7	1623	c.1610G>A	c.(1609-1611)CGG>CAG	p.R537Q	KCNH2_uc003wib.2_Missense_Mutation_p.R197Q|KCNH2_uc011kux.1_Missense_Mutation_p.R441Q|KCNH2_uc003wid.2_Missense_Mutation_p.R197Q|KCNH2_uc003wie.2_Missense_Mutation_p.R537Q	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	537	Helical; Voltage-sensor; Name=Segment S4; (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	ATCCAGCTTCCGCGCCACGCG	0.657000												
GALNT11	63917	broad.mit.edu	37	7	151805280	151805280	+	Silent	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr7:151805280C>T	uc010lqg.1	+	6	1100	c.870C>T	c.(868-870)GTC>GTT	p.V290V	GALNT11_uc011kvm.1_Silent_p.V209V|GALNT11_uc003wku.2_Silent_p.V290V|GALNT11_uc011kvn.1_RNA|GALNT11_uc003wkw.1_Silent_p.V38V	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	290	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		CCCCTGTCGTCCGCGGAGGGT	0.602000												
DLC1	10395	broad.mit.edu	37	8	12957702	12957702	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:12957702T>C	uc003wwm.2	-	9	2588	c.2144A>G	c.(2143-2145)GAG>GGG	p.E715G	DLC1_uc003wwk.1_Missense_Mutation_p.E278G|DLC1_uc003wwl.1_Missense_Mutation_p.E312G|DLC1_uc011kxx.1_Missense_Mutation_p.E204G	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	715					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						GGCGGAGATCTCCACGCAGTT	0.582000												
TUSC3	7991	broad.mit.edu	37	8	15397991	15397991	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:15397991C>T	uc003wwt.2	+	1	262	c.52C>T	c.(52-54)CGG>TGG	p.R18W	TUSC3_uc003wwr.2_Missense_Mutation_p.R18W|TUSC3_uc003wws.2_Missense_Mutation_p.R18W|TUSC3_uc003wwu.2_Missense_Mutation_p.R18W|TUSC3_uc003wwv.2_Missense_Mutation_p.R18W|TUSC3_uc003www.2_Missense_Mutation_p.R18W|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.R18W	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	18					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		GCGGCGGCTGCGGTACCTGCC	0.687000												
UNC5D	137970	broad.mit.edu	37	8	35541183	35541183	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:35541183C>T	uc003xjr.1	+	5	1017	c.689C>T	c.(688-690)ACC>ATC	p.T230I	UNC5D_uc003xjs.1_Missense_Mutation_p.T225I|UNC5D_uc003xjt.1_5'UTR	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	230	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GGAAATTACACCTGCATGGCA	0.537000												
MRPL15	29088	broad.mit.edu	37	8	55060008	55060008	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:55060008C>T	uc003xsa.2	+	5	683	c.620C>T	c.(619-621)CCA>CTA	p.P207L		NM_014175	NP_054894	Q9P015	RM15_HUMAN	mitochondrial ribosomal protein L15 precursor	207					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0		Lung NSC(129;0.109)|all_epithelial(80;0.134)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;4.3e-07)|Epithelial(17;5.79e-05)|all cancers(17;0.000458)			ATGCTTCCACCAGAAGAACTG	0.413000												
CA3	761	broad.mit.edu	37	8	86360349	86360349	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:86360349C>G	uc003ydj.2	+	7	833	c.750C>G	c.(748-750)ATC>ATG	p.I250M	CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	250					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						CACAGCCTATCAATAACAGGG	0.562000												
NECAB1	64168	broad.mit.edu	37	8	91940518	91940518	+	Silent	SNP	G	G	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:91940518G>T	uc011lgg.1	+	8	878	c.684G>T	c.(682-684)CTG>CTT	p.L228L		NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	228	Potential.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			TTGATAGACTGGAAAAGAAGG	0.403000												
ZFPM2	23414	broad.mit.edu	37	8	106815129	106815129	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:106815129A>G	uc003ymd.2	+	8	2842	c.2819A>G	c.(2818-2820)CAA>CGA	p.Q940R	ZFPM2_uc011lhs.1_Missense_Mutation_p.Q671R	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	940					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GCAACCCTGCAAGGCTTGAAG	0.413000												
ZNF572	137209	broad.mit.edu	37	8	125990059	125990059	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:125990059C>T	uc003yrr.2	+	3	1704	c.1549C>T	c.(1549-1551)CCC>TCC	p.P517S		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGGGGAAATGCCCTTCATCTC	0.438000										HNSCC(60;0.17)		
GPT	2875	broad.mit.edu	37	8	145731400	145731400	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr8:145731400C>T	uc011lli.1	+	8	999	c.842C>T	c.(841-843)GCC>GTC	p.A281V	GPT_uc011llj.1_Silent_p.R303R|GPT_uc003zdh.3_Missense_Mutation_p.A281V	NM_005309	NP_005300	P24298	ALAT1_HUMAN	glutamic pyruvate transaminase	281					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)|central_nervous_system(1)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AACGTGTACGCCGCGGGTTCG	0.677000												
SETX	23064	broad.mit.edu	37	9	135202659	135202660	+	Nonsense_Mutation	DNP	AC	AC	CT			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr9:135202659_135202660AC>CT	uc004cbk.2	-	10	4508_4509	c.4325_4326GT>AG	c.(4324-4326)TGT>TAG	p.C1442*	SETX_uc004cbj.2_Nonsense_Mutation_p.C1061*|SETX_uc010mzt.2_Nonsense_Mutation_p.C1061*	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	1442					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CTACAGAATCACACTGGTTCAA	0.416000												
USP11	8237	broad.mit.edu	37	X	47092439	47092439	+	Silent	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:47092439G>A	uc004dhp.2	+	1	126	c.126G>A	c.(124-126)ACG>ACA	p.T42T		NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	42					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GAGAACGgacggcgatggcga	0.383000												
AR	367	broad.mit.edu	37	X	66765885	66765885	+	Silent	SNP	A	A	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:66765885A>T	uc004dwu.1	+	1	2012	c.897A>T	c.(895-897)GCA>GCT	p.A299A	AR_uc011mpd.1_Silent_p.A299A|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Silent_p.A299A	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	297	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	ACGACAGCGCAGGCAAGAGCA	0.567000									Androgen_Insensitivity_Syndrome			
NAP1L2	4674	broad.mit.edu	37	X	72432992	72432992	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:72432992G>A	uc004ebi.2	-	1	1693	c.1337C>T	c.(1336-1338)GCT>GTT	p.A446V	NAP1L2_uc011mqj.1_Missense_Mutation_p.A304V	NM_021963	NP_068798	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	446					nucleosome assembly	chromatin assembly complex				lung(1)	1	Renal(35;0.156)					TTTGCAACAAGCTTTAACTTC	0.378000												
CDX4	1046	broad.mit.edu	37	X	72667379	72667379	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:72667379C>T	uc011mqk.1	+	1	290	c.290C>T	c.(289-291)CCG>CTG	p.P97L		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	97						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					GGCACAGTGCCGGTGAACGAC	0.642000												
CYSLTR1	10800	broad.mit.edu	37	X	77529219	77529219	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:77529219C>T	uc004edb.2	-	3	425	c.25G>A	c.(25-27)GTA>ATA	p.V9I	CYSLTR1_uc010nma.2_Missense_Mutation_p.V9I|CYSLTR1_uc010nmb.2_Missense_Mutation_p.V9I	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	9	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	GCAGAAGATACTGTCAGATTT	0.363000												
COL4A6	1288	broad.mit.edu	37	X	107412759	107412759	+	Silent	SNP	C	C	A			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:107412759C>A	uc004enw.3	-	37	3763	c.3660G>T	c.(3658-3660)GGG>GGT	p.G1220G	COL4A6_uc004env.3_Silent_p.G1219G|COL4A6_uc011msn.1_Silent_p.G1195G|COL4A6_uc010npk.2_Silent_p.G1195G	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	1220	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						GGCCCGGCTTCCCTGGAGCTC	0.572000									Alport_syndrome_with_Diffuse_Leiomyomatosis			
HTR2C	3358	broad.mit.edu	37	X	114141785	114141785	+	Missense_Mutation	SNP	T	T	A	rs151266355		TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:114141785T>A	uc004epu.1	+	6	1912	c.1184T>A	c.(1183-1185)GTC>GAC	p.V395D	HTR2C_uc010nqc.1_Missense_Mutation_p.V395D|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	395	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	AAGCCTCCTGTCAGGCAGATT	0.443000												
DCAF12L2	340578	broad.mit.edu	37	X	125299259	125299259	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:125299259C>T	uc004euk.1	-	1	676	c.649G>A	c.(649-651)GTG>ATG	p.V217M		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	217	WD 2.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						CACAGAGCCACGGTGCCGTCG	0.637000												
MOSPD1	56180	broad.mit.edu	37	X	134025640	134025640	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:134025640A>G	uc004eyb.2	-	5	666	c.479T>C	c.(478-480)TTA>TCA	p.L160S	MOSPD1_uc004eya.2_Intron|MOSPD1_uc010nrv.2_RNA	NM_019556	NP_062456	Q9UJG1	MSPD1_HUMAN	motile sperm domain containing 1	160	Helical; (Potential).				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	integral to membrane|nucleus|perinuclear region of cytoplasm	structural molecule activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(192;0.000127)					GACAGTTAGTAAACTAGGTCC	0.453000												
MAP7D3	79649	broad.mit.edu	37	X	135314089	135314089	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:135314089C>T	uc004ezt.2	-	8	1118	c.1027G>A	c.(1027-1029)GTG>ATG	p.V343M	MAP7D3_uc004ezs.2_Missense_Mutation_p.V307M|MAP7D3_uc011mwc.1_Missense_Mutation_p.V325M|MAP7D3_uc010nsa.1_Missense_Mutation_p.V301M	NM_024597	NP_078873	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	343						cytoplasm|spindle				ovary(2)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;0.000127)					GACACGTCCACGCTCACCACA	0.567000												
MAGEA10	4109	broad.mit.edu	37	X	151303170	151303170	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:151303170T>G	uc004ffk.2	-	5	1331	c.923A>C	c.(922-924)AAG>ACG	p.K308T	MAGEA10_uc004ffl.2_Missense_Mutation_p.K308T	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	308	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GAGACTCATCTTCCTAATTTC	0.507000												
SLC10A3	8273	broad.mit.edu	37	X	153716440	153716440	+	Silent	SNP	G	G	A	rs151043660		TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chrX:153716440G>A	uc004flq.2	-	3	1104	c.840C>T	c.(838-840)GAC>GAT	p.D280D	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Silent_p.D251D|SLC10A3_uc004flp.2_Silent_p.D280D	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	280					organic anion transport	integral to membrane	bile acid:sodium symporter activity	p.D280N(1)		ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCAGGGTGACGTCCCCTCCAA	0.622000												
MYH10	4628	broad.mit.edu	37	17	8398465	8398466	+	In_Frame_Ins	INS	-	-	GTA			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr17:8398465_8398466insGTA	uc002gll.2	-	29	4048_4049	c.3952_3953insTAC	c.(3952-3954)CAG>CTACAG	p.1317_1318insL	MYH10_uc002glm.2_In_Frame_Ins_p.1348_1349insL|MYH10_uc010cnx.2_In_Frame_Ins_p.1326_1327insL	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1317_1318	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CTGTGTATCCTGTAGTTGAGAC	0.416												
SRBD1	55133	broad.mit.edu	37	2	45620206	45620207	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr2:45620206_45620207insT	uc002rus.2	-	20	2651_2652	c.2575_2576insA	c.(2575-2577)ATAfs	p.I859fs	SRBD1_uc010yoc.1_Frame_Shift_Ins_p.I378fs	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	859					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			GAATGAATTTATTTTTTGTTGC	0.386												
BCAN	63827	broad.mit.edu	37	1	156616753	156616756	+	Frame_Shift_Del	DEL	GGGC	GGGC	-			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr1:156616752_156616755GGGGC>G	uc001fpp.3	+	2	587_590	c.251_254GGGGC>G	c.(250-255)cggggcfs	p.R84fs	BCAN_uc001fpo.3_Frame_Shift_Del_p.R84fs	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	Homo sapiens brevican (BCAN), transcript variant 1, mRNA.	84	Ig-like V-type.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTCCTGTCCCGGGGCCGGGAGGCA	0.716												
SRBD1	55133	broad.mit.edu	37	2	45620207	45620208	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr2:45620206_45620207A>AT	uc002rus.3	-	19	2651_2652	c.2575_2576T>AT	c.(2575-2577)atafs	p.I859fs	SRBD1_uc010yoc.2_Frame_Shift_Ins_p.I378fs	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	Homo sapiens S1 RNA binding domain 1 (SRBD1), mRNA.	859					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		RNA binding|hydrolase activity, acting on ester bonds			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			GAATGAATTTATTTTTTGTTGC	0.386												
MYH10	4628	broad.mit.edu	37	17	8398466	8398467	+	In_Frame_Ins	INS	-	-	GTA			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr17:8398465_8398466T>TGTA	uc002glm.3	-	30	4141_4142	c.4045_4046A>TACA	c.(4045-4047)cag>TACAg	p.Q1349Y	MYH10_uc002gll.3_In_Frame_Ins_p.Q1318Y|MYH10_uc010cnx.3_In_Frame_Ins_p.Q1327Y	NM_005964	NP_005955	P35580	MYH10_HUMAN	Homo sapiens myosin, heavy chain 10, non-muscle (MYH10), transcript variant 2, mRNA.	1318					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	ADP binding|ATP binding|actin filament binding|actin-dependent ATPase activity|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CTGTGTATCCTGTAGTTGAGAC	0.416												
GRP	2922	broad.mit.edu	37	18	56892756	56892758	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr18:56892755_56892757GTCT>G	uc002lhv.3	+	1	269_271	c.171_173GTCT>G	c.(169-174)gagtct>gaGt	p.S60del	GRP_uc002lhu.3_In_Frame_Del_p.S60del|GRP_uc002lhw.3_In_Frame_Del_p.S60del	NM_002091	NP_002082	P07492	GRP_HUMAN	Homo sapiens gastrin-releasing peptide (GRP), transcript variant 1, mRNA.	60					neuropeptide signaling pathway	extracellular space	neuropeptide hormone activity			large_intestine(1)|lung(3)	4		Colorectal(73;0.0946)				GCACAGGGGAGTCTTCTTCTGTT	0.429												
ZSCAN18	65982	broad.mit.edu	37	19	58600101	58600102	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-8077-01A-11D-2340-08	TCGA-BR-8077-10A-01D-2340-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	141af187-b767-4e25-8b46-dfa8618b1794	4ff305bd-6a6a-4583-a89c-ddab140a042d	g.chr19:58600100_58600101T>TG	uc010yht.1	-	2	705_706	c.675_676A>CA	c.(673-678)cccagcfs	p.P225fs	ZSCAN18_uc002qrj.3_Frame_Shift_Ins_p.P169fs|ZSCAN18_uc010yhs.1_Frame_Shift_Ins_p.P34fs|ZSCAN18_uc002qrh.2_Frame_Shift_Ins_p.P169fs|ZSCAN18_uc002qri.2_Frame_Shift_Ins_p.P169fs|ZSCAN18_uc002qrk.1_Frame_Shift_Ins_p.P169fs|ZSCAN18_uc002qrl.2_Frame_Shift_Ins_p.P169fs	NM_001145542	NP_001139014	Q8TBC5	ZSC18_HUMAN	Homo sapiens zinc finger and SCAN domain containing 18 (ZSCAN18), transcript variant 1, mRNA.	169					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGGGCCTGGCTGGGGCTCGCGA	0.649