Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
AJAP1	55966	broad.mit.edu	37	1	4832465	4832465	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:4832465C>A	uc001alm.1	+	4	1424	c.1043C>A	c.(1042-1044)ACG>AAG	p.T348K	AJAP1_uc001aln.2_Missense_Mutation_p.T348K	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	348	Targeting signals.|Cytoplasmic (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		GACATATTCACGGCCTATAAC	0.617000												
PER3	8863	broad.mit.edu	37	1	7879395	7879395	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:7879395G>T	uc001aoo.2	+	13	1724	c.1549G>T	c.(1549-1551)GTG>TTG	p.V517L	PER3_uc009vmg.1_Missense_Mutation_p.V525L|PER3_uc009vmh.1_Missense_Mutation_p.V518L|PER3_uc001aop.2_Missense_Mutation_p.V525L|PER3_uc010nzw.1_Missense_Mutation_p.V206L	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	517	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		AAACAATAGTGTGTACACTGA	0.423000												
PEX14	5195	broad.mit.edu	37	1	10687392	10687392	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:10687392A>G	uc001arn.2	+	8	670	c.649A>G	c.(649-651)AAC>GAC	p.N217D	PEX14_uc009vmv.2_Missense_Mutation_p.N153D|PEX14_uc010oam.1_Missense_Mutation_p.N153D|PEX14_uc010oan.1_Missense_Mutation_p.N174D|PEX14_uc009vmw.2_Missense_Mutation_p.N153D	NM_004565	NP_004556	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	217					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(1)	1	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		GTCCGAAATTAACTCCTTGAA	0.567000												
SPEN	23013	broad.mit.edu	37	1	16248837	16248837	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:16248837G>A	uc001axk.1	+	10	2047	c.1843G>A	c.(1843-1845)GAA>AAA	p.E615K	SPEN_uc010obp.1_Missense_Mutation_p.E574K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	615					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AATGTTAGCCGAAAGAAGGTA	0.234000												
RAP1GAP	5909	broad.mit.edu	37	1	21929359	21929359	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:21929359C>T	uc001bex.2	-	19	1734	c.1476G>A	c.(1474-1476)CCG>CCA	p.P492P	RAP1GAP_uc001bev.2_Silent_p.P577P|RAP1GAP_uc001bew.2_Silent_p.P556P|RAP1GAP_uc001bey.2_Silent_p.P518P	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	492					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GGGAGCCGAACGGGCCCGACT	0.642000												
KIAA0467	23334	broad.mit.edu	37	1	43908169	43908169	+	Silent	SNP	G	G	A	rs138303356		TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:43908169G>A	uc001cjk.1	+	43	5796	c.5334G>A	c.(5332-5334)GCG>GCA	p.A1778A		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2677						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGGGCCGAGCGCTGGTTCGCC	0.597000												
C1orf141	400757	broad.mit.edu	37	1	67591441	67591441	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:67591441G>C	uc001ddl.1	-	3	338	c.227C>G	c.(226-228)TCA>TGA	p.S76*	C1orf141_uc001ddm.1_Nonsense_Mutation_p.S76*|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	76										ovary(1)	1						TTACATTTTTGATTTTGTAAT	0.239000												
USP33	23032	broad.mit.edu	37	1	78201795	78201795	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:78201795C>T	uc001dht.2	-	7	840	c.493G>A	c.(493-495)GTA>ATA	p.V165I	USP33_uc001dhu.2_Missense_Mutation_p.V134I|USP33_uc001dhv.2_5'UTR|USP33_uc001dhw.2_Missense_Mutation_p.V165I	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	165					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						TCATCAAATACGGCAACCAGA	0.343000												
DPYD	1806	broad.mit.edu	37	1	97915676	97915676	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:97915676T>G	uc001drv.2	-	14	1981	c.1844A>C	c.(1843-1845)GAG>GCG	p.E615A		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	615					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AGCCGTTTTCTCACTGATGAG	0.443000												
ADORA3	140	broad.mit.edu	37	1	112045631	112045631	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:112045631C>T	uc001ebh.3	-	1	1113	c.346G>A	c.(346-348)GTC>ATC	p.V116I	ADORA3_uc001ebg.3_Intron|ADORA3_uc001ebf.2_Missense_Mutation_p.V116I	NM_000677	NP_000668	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 2	116	Cytoplasmic (By similarity).				activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GGCTACCTGACGGTAAGCTTG	0.522000												
HRNR	388697	broad.mit.edu	37	1	152185618	152185618	+	Silent	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:152185618G>C	uc001ezt.1	-	3	8563	c.8487C>G	c.(8485-8487)CTC>CTG	p.L2829L		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2829					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGGAAAACTGAGAAAATATG	0.403000												
HRNR	388697	broad.mit.edu	37	1	152185707	152185707	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:152185707G>C	uc001ezt.1	-	3	8474	c.8398C>G	c.(8398-8400)CAG>GAG	p.Q2800E		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2800	30.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTCCATGCTGACTATAACCA	0.522000												
HRNR	388697	broad.mit.edu	37	1	152185775	152185775	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:152185775G>C	uc001ezt.1	-	3	8406	c.8330C>G	c.(8329-8331)TCT>TGT	p.S2777C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2777	30.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTGAACCAGACCCGTGTCG	0.592000												
FLG2	388698	broad.mit.edu	37	1	152330090	152330090	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:152330090T>C	uc001ezw.3	-	3	245	c.172A>G	c.(172-174)ATG>GTG	p.M58V	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	58	S-100-like (By similarity).|EF-hand 2.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCATATGCATGATGACATCC	0.438000												
LCE2B	26239	broad.mit.edu	37	1	152659558	152659558	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:152659558T>C	uc001fai.2	+	2	293	c.239T>C	c.(238-240)CTC>CCC	p.L80P		NM_014357	NP_055172	O14633	LCE2B_HUMAN	late cornified envelope 2B	80	Cys-rich.				keratinization					ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGCCCCGTCTCTTCCACCGG	0.687000												
SPRR3	6707	broad.mit.edu	37	1	152975747	152975747	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:152975747A>C	uc001fax.3	+	3	401	c.251A>C	c.(250-252)AAG>ACG	p.K84T	SPRR3_uc001faz.3_Missense_Mutation_p.K84T|SPRR3_uc001fay.2_Missense_Mutation_p.K76T	NM_005416	NP_005407	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	84	6.|14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			skin(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGTTGTACCAAGGTCCCTGAG	0.592000												
OR10K2	391107	broad.mit.edu	37	1	158390620	158390620	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:158390620T>A	uc010pii.1	-	1	37	c.37A>T	c.(37-39)ATC>TTC	p.I13F		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					CCGAGGAAGATGACCTCTCTC	0.512000												
OR10K1	391109	broad.mit.edu	37	1	158435654	158435654	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:158435654G>A	uc010pij.1	+	1	303	c.303G>A	c.(301-303)ATG>ATA	p.M101I		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	101	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CCATCCAAATGTTTTCCTTCC	0.502000												
SPTA1	6708	broad.mit.edu	37	1	158639573	158639573	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:158639573C>T	uc001fst.1	-	13	1802	c.1603G>A	c.(1603-1605)GTA>ATA	p.V535I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	535	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GTCTTGTCTACAGTCTGAAAA	0.403000												
OR6K6	128371	broad.mit.edu	37	1	158724937	158724937	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:158724937C>T	uc001fsw.1	+	1	332	c.332C>T	c.(331-333)TCC>TTC	p.S111F		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	111	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					AAGATGCTGTCCTGCCTAATC	0.512000												
RGS4	5999	broad.mit.edu	37	1	163044232	163044232	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:163044232G>A	uc009wuy.2	+	5	1011	c.500G>A	c.(499-501)CGC>CAC	p.R167H	RGS4_uc001gcl.3_Missense_Mutation_p.R264H|RGS4_uc009wuz.2_3'UTR|RGS4_uc009wva.2_Missense_Mutation_p.R149H	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	167	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						TCCTACCGCCGCTTCCTCAAG	0.502000												
LMX1A	4009	broad.mit.edu	37	1	165175151	165175151	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:165175151C>T	uc001gcy.1	-	7	1159	c.938G>A	c.(937-939)CGA>CAA	p.R313Q	LMX1A_uc001gcz.1_Missense_Mutation_p.R313Q|LMX1A_uc001gcw.1_Missense_Mutation_p.R31Q|LMX1A_uc001gcx.1_Missense_Mutation_p.R64Q	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	313						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					GAGACCCTGTCGGAAGGGATC	0.582000												
TPR	7175	broad.mit.edu	37	1	186324590	186324590	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:186324590C>T	uc001grv.2	-	17	2420	c.2123G>A	c.(2122-2124)CGA>CAA	p.R708Q		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	708	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ATTTTGTGATCGCAAATCTGT	0.284000			T	NTRK1	papillary thyroid							
CFHR3	10878	broad.mit.edu	37	1	196748352	196748352	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:196748352G>A	uc001gtl.2	+	2	206	c.119G>A	c.(118-120)AGA>AAA	p.R40K	CFHR3_uc001gtk.2_Missense_Mutation_p.R40K|CFHR3_uc010poy.1_Missense_Mutation_p.R40K|CFHR1_uc001gtm.2_Missense_Mutation_p.R3K	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	40	Sushi 1.					extracellular space					0						AATATGCGTAGACCATACTTT	0.323000												
CFHR3	10878	broad.mit.edu	37	1	196749078	196749078	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:196749078T>C	uc001gtl.2	+	3	492	c.405T>C	c.(403-405)TCT>TCC	p.S135S	CFHR3_uc001gtk.2_Silent_p.S135S|CFHR3_uc010poy.1_Silent_p.S135S|CFHR1_uc001gtm.2_Intron	NM_021023	NP_066303	Q02985	FHR3_HUMAN	complement factor H-related 3 precursor	135	Sushi 2.					extracellular space					0						AAGGCTGGTCTCCTACTCCCA	0.493000												
PTPRC	5788	broad.mit.edu	37	1	198711490	198711490	+	Silent	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:198711490A>G	uc001gur.1	+	25	2865	c.2685A>G	c.(2683-2685)CAA>CAG	p.Q895Q	PTPRC_uc001gus.1_Silent_p.Q847Q|PTPRC_uc001gut.1_Silent_p.Q734Q	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	895	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.	Substrate (By similarity).			axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TGATGGTTCAAGTAGAGGTAT	0.363000												
INTS7	25896	broad.mit.edu	37	1	212156066	212156066	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:212156066G>A	uc001hiw.1	-	9	1189	c.1084C>T	c.(1084-1086)CAT>TAT	p.H362Y	INTS7_uc009xdb.1_Missense_Mutation_p.H362Y|INTS7_uc001hix.1_Missense_Mutation_p.H238Y|INTS7_uc001hiy.1_Missense_Mutation_p.H362Y|INTS7_uc010pta.1_Missense_Mutation_p.H313Y	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	362					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CTAACTCCATGAGCTGCAATG	0.378000												
ACTN2	88	broad.mit.edu	37	1	236914822	236914822	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:236914822G>C	uc001hyf.2	+	15	1913	c.1709G>C	c.(1708-1710)GGA>GCA	p.G570A	ACTN2_uc001hyg.2_Missense_Mutation_p.G362A|ACTN2_uc009xgi.1_Missense_Mutation_p.G570A|ACTN2_uc010pxu.1_Missense_Mutation_p.G259A|ACTN2_uc001hyh.2_Missense_Mutation_p.G258A	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	570	Spectrin 3.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGGCGGACGGAGAGCGGCAG	0.537000												
RYR2	6262	broad.mit.edu	37	1	237617865	237617865	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:237617865C>T	uc001hyl.1	+	15	1587	c.1467C>T	c.(1465-1467)TTC>TTT	p.F489F		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	489	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAATCTCTTCCAGGAAGAGG	0.423000												
RYR2	6262	broad.mit.edu	37	1	237675029	237675029	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:237675029G>A	uc001hyl.1	+	24	2880	c.2760G>A	c.(2758-2760)GAG>GAA	p.E920E		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	920	Cytoplasmic (By similarity).|1.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCCTGGTGGAGTTCTCCAAGC	0.438000												
PLD5	200150	broad.mit.edu	37	1	242511425	242511425	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:242511425A>T	uc001hzn.1	-	2	436	c.309T>A	c.(307-309)AAT>AAA	p.N103K	PLD5_uc001hzl.3_Missense_Mutation_p.N41K|PLD5_uc001hzm.3_Translation_Start_Site|PLD5_uc001hzo.1_Missense_Mutation_p.I9N			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	103						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TATTTTGGCAATTTTTTTCTG	0.443000												
OR2T6	254879	broad.mit.edu	37	1	248551074	248551074	+	Silent	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:248551074C>A	uc001iei.1	+	1	165	c.165C>A	c.(163-165)CTC>CTA	p.L55L		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L55P(1)		ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCCTCATCTCCACACCCCCA	0.473000												
OR2T3	343173	broad.mit.edu	37	1	248637588	248637588	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:248637588A>G	uc001iel.1	+	1	937	c.937A>G	c.(937-939)AGA>GGA	p.R313G		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGCAGTCAAGAATGAACCA	0.483000												
OR2T10	127069	broad.mit.edu	37	1	248756332	248756332	+	Silent	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr1:248756332T>A	uc010pzn.1	-	1	738	c.738A>T	c.(736-738)ACA>ACT	p.T246T		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGCTGACCACTGTAATGTGGG	0.443000												
ZNF248	57209	broad.mit.edu	37	10	38121107	38121107	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr10:38121107C>T	uc001izd.1	-	6	1675	c.1176G>A	c.(1174-1176)AAG>AAA	p.K392K	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Silent_p.K392K	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	392	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGAGGTTTGACTTCTCCCAGA	0.458000												
DNTT	1791	broad.mit.edu	37	10	98087281	98087281	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr10:98087281G>A	uc001kmf.2	+	7	1101	c.931G>A	c.(931-933)GTC>ATC	p.V311I	DNTT_uc001kmg.2_Missense_Mutation_p.V311I	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	311	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AGCAGAGGCCGTCAGTGTGCT	0.517000												
PDCD11	22984	broad.mit.edu	37	10	105199528	105199528	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr10:105199528G>C	uc001kwy.1	+	28	4138	c.4051G>C	c.(4051-4053)GCT>CCT	p.A1351P		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1351	S1 motif 12.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TGTGGGTTTGGCTCGGTACTC	0.552000												
SORCS3	22986	broad.mit.edu	37	10	106401694	106401694	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr10:106401694G>C	uc001kyi.1	+	1	836	c.609G>C	c.(607-609)TGG>TGC	p.W203C		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	203	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TGGTGCACTGGTCGGGACACA	0.701000												
GPAM	57678	broad.mit.edu	37	10	113917086	113917086	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr10:113917086G>C	uc009xxy.1	-	19	2240	c.2042C>G	c.(2041-2043)CCA>CGA	p.P681R	GPAM_uc001kzp.2_Missense_Mutation_p.P681R|GPAM_uc001kzq.1_Missense_Mutation_p.P681R	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	681	Mitochondrial intermembrane (Potential).|Mitochondrial intermembrane (Potential).				phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		CAAAGGTTCTGGAAGCTTCTT	0.458000												
DCLRE1A	9937	broad.mit.edu	37	10	115605541	115605541	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr10:115605541T>A	uc001law.2	-	4	3199	c.2281A>T	c.(2281-2283)AAC>TAC	p.N761Y		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	761					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		TGAAGCTTGTTCTTCAACAAA	0.358000								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function				
IFITM1	8519	broad.mit.edu	37	11	314303	314303	+	Missense_Mutation	SNP	C	C	T	rs11552362		TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:314303C>T	uc001loy.3	+	1	313	c.133C>T	c.(133-135)CTC>TTC	p.L45F		NM_003641	NP_003632	P13164	IFM1_HUMAN	interferon induced transmembrane protein 1	45	Helical; (Potential).				negative regulation of cell proliferation|regulation of immune response|response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding|receptor signaling protein activity				0		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		GTTCAACACCCTCTTCTTGAA	0.617000												
OR51L1	119682	broad.mit.edu	37	11	5020810	5020810	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:5020810T>C	uc010qyu.1	+	1	598	c.598T>C	c.(598-600)TAT>CAT	p.Y200H		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAACAGTATTTATGGGCTTTG	0.428000												
OR10A5	144124	broad.mit.edu	37	11	6867680	6867680	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:6867680C>G	uc001met.1	+	1	767	c.767C>G	c.(766-768)TCT>TGT	p.S256C		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	256	Helical; Name=6; (Potential).			S -> L (in Ref. 4; AAC70019).	sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TATATATCTTCTAGCCTCACC	0.433000												
OR10A5	144124	broad.mit.edu	37	11	6867694	6867694	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:6867694T>G	uc001met.1	+	1	781	c.781T>G	c.(781-783)TTC>GTC	p.F261V		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCTCACCTACTTCTGGCCTAA	0.423000												
OVCH2	341277	broad.mit.edu	37	11	7718031	7718031	+	Silent	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:7718031A>T	uc010rbf.1	-	10	1122	c.1122T>A	c.(1120-1122)TCT>TCA	p.S374S		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		TGTCTTCTAAAGAATACATTG	0.458000												
NELL1	4745	broad.mit.edu	37	11	20948910	20948910	+	Silent	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:20948910T>G	uc001mqe.2	+	8	969	c.816T>G	c.(814-816)ACT>ACG	p.T272T	NELL1_uc001mqf.2_Silent_p.T272T|NELL1_uc009yid.2_Silent_p.T300T|NELL1_uc010rdo.1_Silent_p.T215T|NELL1_uc010rdp.1_Silent_p.T32T	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	272	VWFC 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GTGAGAAGACTTGTCAAGTGA	0.383000												
NELL1	4745	broad.mit.edu	37	11	20959356	20959356	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:20959356T>G	uc001mqe.2	+	10	1175	c.1022T>G	c.(1021-1023)GTT>GGT	p.V341G	NELL1_uc001mqf.2_Missense_Mutation_p.V341G|NELL1_uc009yid.2_Missense_Mutation_p.V369G|NELL1_uc010rdo.1_Missense_Mutation_p.V284G|NELL1_uc010rdp.1_Missense_Mutation_p.V101G	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	341	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GGAGGAAAAGTTCTTGCAGAA	0.408000												
LRRC4C	57689	broad.mit.edu	37	11	40136487	40136487	+	Silent	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:40136487A>T	uc001mxa.1	-	2	3320	c.1356T>A	c.(1354-1356)TCT>TCA	p.S452S	LRRC4C_uc001mxc.1_Silent_p.S448S|LRRC4C_uc001mxd.1_Silent_p.S448S|LRRC4C_uc001mxb.1_Silent_p.S448S	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	452					regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				TTGAAAAGTAAGAGAAAGGAG	0.483000												
OR4A47	403253	broad.mit.edu	37	11	48511093	48511093	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:48511093T>A	uc010rhx.1	+	1	749	c.749T>A	c.(748-750)GTT>GAT	p.V250D		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTCTTCTTTGTTCCTTGTATT	0.433000												
OR8H3	390152	broad.mit.edu	37	11	55890577	55890577	+	Silent	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:55890577T>A	uc001nii.1	+	1	729	c.729T>A	c.(727-729)TCT>TCA	p.S243S		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					CTTGCGTCTCTCATCTCTTGG	0.403000												
OR8J1	219477	broad.mit.edu	37	11	56127847	56127847	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:56127847A>G	uc010rjh.1	+	1	125	c.125A>G	c.(124-126)AAC>AGC	p.N42S		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATGGCAGGGAACCTGGGCATC	0.493000												
CLP1	10978	broad.mit.edu	37	11	57427134	57427134	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:57427134G>A	uc001nkw.2	+	2	325	c.186G>A	c.(184-186)AAG>AAA	p.K62K	CLP1_uc010rjw.1_Silent_p.K62K|CLP1_uc009yml.2_Silent_p.K62K	NM_006831	NP_006822	Q92989	CLP1_HUMAN	ATP/GTP-binding protein isoform 1	62					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|siRNA loading onto RISC involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|termination of RNA polymerase II transcription|tRNA splicing, via endonucleolytic cleavage and ligation	nucleoplasm|tRNA-intron endonuclease complex	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity			ovary(1)	1						CTGGTGCCAAGGTGGCTGTTT	0.502000												
FADS2	9415	broad.mit.edu	37	11	61624490	61624490	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:61624490A>G	uc001nsl.1	+	6	902	c.752A>G	c.(751-753)AAG>AGG	p.K251R	FADS2_uc001nsj.2_Missense_Mutation_p.K229R|FADS2_uc010rlo.1_Missense_Mutation_p.K220R|FADS2_uc001nsk.2_Missense_Mutation_p.K251R	NM_004265	NP_004256	O95864	FADS2_HUMAN	fatty acid desaturase 2	251	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			ovary(1)|pancreas(1)	2					Alpha-Linolenic Acid(DB00132)	CAGTACGGCAAGAAGAAGCTG	0.572000												
RBM4	5936	broad.mit.edu	37	11	66411193	66411193	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:66411193C>T	uc009yrj.2	+	3	1173	c.685C>T	c.(685-687)CGG>TGG	p.R229W	RBM4_uc009yrk.2_Missense_Mutation_p.R204W|RBM4_uc001oiw.1_Missense_Mutation_p.R229W|RBM4_uc001oix.1_Intron|RBM4_uc010rpj.1_Intron|RBM4_uc001oiy.1_Missense_Mutation_p.R229W|RBM4_uc001oiz.1_Missense_Mutation_p.R229W	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	229	Interaction with TNPO3.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		CCGTGCTGCCCGGTCCTATGA	0.567000												
P2RY6	5031	broad.mit.edu	37	11	73008014	73008014	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:73008014G>A	uc001otm.2	+	4	856	c.451G>A	c.(451-453)GTG>ATG	p.V151M	P2RY6_uc001otn.2_Missense_Mutation_p.V151M|P2RY6_uc001oto.2_Missense_Mutation_p.V151M|P2RY6_uc001otp.2_Missense_Mutation_p.V151M|P2RY6_uc001otq.2_Missense_Mutation_p.V151M|P2RY6_uc001otr.2_Missense_Mutation_p.V151M|P2RY6_uc001ots.2_Missense_Mutation_p.V151M	NM_176796	NP_789766	Q15077	P2RY6_HUMAN	pyrimidinergic receptor P2Y6	151	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						GTGTGTAGCCGTGTGGCTGGC	0.667000												
C2CD3	26005	broad.mit.edu	37	11	73844002	73844002	+	Silent	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:73844002A>G	uc001ouu.2	-	7	1331	c.1104T>C	c.(1102-1104)TCT>TCC	p.S368S	C2CD3_uc001ouv.2_Silent_p.S368S	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	368						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					ACCGATTCCTAGAAAAGGCTC	0.403000												
HEPHL1	341208	broad.mit.edu	37	11	93808527	93808527	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:93808527C>T	uc001pep.2	+	9	1849	c.1692C>T	c.(1690-1692)GGC>GGT	p.G564G	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	564	Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GTAAAAAGGGCGTCCTCAATG	0.517000												
ANGPTL5	253935	broad.mit.edu	37	11	101775550	101775550	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:101775550G>A	uc001pgl.2	-	5	1030	c.434C>T	c.(433-435)TCA>TTA	p.S145L		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	145	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		CTCACCATGTGACTGAACAGG	0.353000												
DYNC2H1	79659	broad.mit.edu	37	11	103152957	103152957	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:103152957C>T	uc001pho.2	+	72	10955	c.10811C>T	c.(10810-10812)GCT>GTT	p.A3604V	DYNC2H1_uc001phn.1_Missense_Mutation_p.A3611V|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3604					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTACGGAAAGCTGTAAGTTAA	0.294000												
TTC12	54970	broad.mit.edu	37	11	113235630	113235630	+	Silent	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:113235630T>G	uc001pnu.2	+	21	1995	c.1890T>G	c.(1888-1890)GGT>GGG	p.G630G	TTC12_uc001pnv.2_Silent_p.G636G|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Silent_p.G480G	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	630							binding	p.G630D(1)		pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TCTGCCTTGGTAACTGCATGG	0.542000												
ARHGEF12	23365	broad.mit.edu	37	11	120348905	120348905	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr11:120348905A>C	uc001pxl.1	+	37	3580	c.3573A>C	c.(3571-3573)AAA>AAC	p.K1191N	ARHGEF12_uc009zat.2_Missense_Mutation_p.K1172N|ARHGEF12_uc009zau.1_Missense_Mutation_p.K1088N	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1191					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TATCGTCAAAACCTCAGTCTC	0.388000			T	MLL	AML							
CASC1	55259	broad.mit.edu	37	12	25261681	25261681	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr12:25261681T>C	uc001rgl.2	-	15	2034	c.1952A>G	c.(1951-1953)CAA>CGA	p.Q651R	CASC1_uc001rgk.2_Missense_Mutation_p.Q657R|CASC1_uc001rgm.3_3'UTR|CASC1_uc001rgj.2_Missense_Mutation_p.Q611R|CASC1_uc010sje.1_Missense_Mutation_p.Q592R|CASC1_uc010sjf.1_3'UTR	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	651										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			CTTCAGTCTTTGTGCTCTGTC	0.368000												
SMARCC2	6601	broad.mit.edu	37	12	56568472	56568472	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr12:56568472G>A	uc001skb.2	-	16	1565	c.1459C>T	c.(1459-1461)CGC>TGC	p.R487C	SMARCC2_uc001skd.2_Missense_Mutation_p.R487C|SMARCC2_uc001ska.2_Missense_Mutation_p.R487C|SMARCC2_uc001skc.2_Missense_Mutation_p.R487C|SMARCC2_uc010sqf.1_Missense_Mutation_p.R376C	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	487	SWIRM.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			AGGTTTCGGCGGCAGGCGGTA	0.517000												
LRRC10	376132	broad.mit.edu	37	12	70003953	70003953	+	Silent	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr12:70003953A>G	uc001svc.2	-	1	990	c.666T>C	c.(664-666)AAT>AAC	p.N222N		NM_201550	NP_963844	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	222						nucleus					0	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TCCTGCAAGGATTGTGGTCAT	0.587000												
PTPRB	5787	broad.mit.edu	37	12	70974970	70974970	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr12:70974970G>A	uc001swb.3	-	8	1800	c.1770C>T	c.(1768-1770)ATC>ATT	p.I590I	PTPRB_uc010sto.1_Silent_p.I590I|PTPRB_uc010stp.1_Silent_p.I500I|PTPRB_uc001swc.3_Silent_p.I808I|PTPRB_uc001swa.3_Silent_p.I808I|PTPRB_uc001swd.3_Silent_p.I807I|PTPRB_uc009zrr.1_Silent_p.I687I	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	590	Fibronectin type-III 7.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CATTTTCATGGATCAGTAAGA	0.463000												
NAV3	89795	broad.mit.edu	37	12	78604244	78604244	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr12:78604244A>G	uc001syp.2	+	40	7278	c.7105A>G	c.(7105-7107)AGC>GGC	p.S2369G	NAV3_uc001syo.2_Missense_Mutation_p.S2347G|NAV3_uc010sub.1_Missense_Mutation_p.S1826G|NAV3_uc009zsf.2_Missense_Mutation_p.S1178G	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	2369						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CGACAGCGAAAGCACCAGCCA	0.388000										HNSCC(70;0.22)		
CHPT1	56994	broad.mit.edu	37	12	102117024	102117024	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr12:102117024A>G	uc001tin.2	+	6	1082	c.859A>G	c.(859-861)ACT>GCT	p.T287A	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Missense_Mutation_p.T287A	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	287					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						AAAGTCAGCAACTGATGTGTT	0.343000												
NUAK1	9891	broad.mit.edu	37	12	106464550	106464550	+	Splice_Site	SNP	A	A	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr12:106464550A>C	uc001tlj.1	-	6	2212	c.832_splice	c.e6+1	p.D278_splice		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5								ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						CAGGGCACGCACCTGAGGGCT	0.507000												
TMEM132D	121256	broad.mit.edu	37	12	129822217	129822217	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr12:129822217T>A	uc009zyl.1	-	4	1589	c.1261A>T	c.(1261-1263)AGC>TGC	p.S421C		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	421	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCCTTTGGGCTCACATAGATC	0.612000												
GJB6	10804	broad.mit.edu	37	13	20796878	20796878	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:20796878T>G	uc001umz.3	-	3	1295	c.742A>C	c.(742-744)ATT>CTT	p.I248L	GJB6_uc001unc.3_Missense_Mutation_p.I248L|GJB6_uc001una.3_Missense_Mutation_p.I248L|GJB6_uc001und.3_Missense_Mutation_p.I248L|GJB6_uc001unb.3_Missense_Mutation_p.I248L	NM_006783	NP_006774	O95452	CXB6_HUMAN	gap junction protein, beta 6	248	Cytoplasmic (Potential).				cell communication|sensory perception of sound	connexon complex|integral to membrane|intracellular membrane-bounded organelle				ovary(1)	1		all_cancers(29;2.04e-22)|all_epithelial(30;1.19e-19)|all_lung(29;2.27e-18)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;2.17e-05)|Epithelial(112;0.00075)|OV - Ovarian serous cystadenocarcinoma(117;0.00978)|Lung(94;0.0238)|GBM - Glioblastoma multiforme(144;0.0323)|LUSC - Lung squamous cell carcinoma(192;0.0744)		CTATCTGAAATCAGCTCATTC	0.408000												
TNFRSF19	55504	broad.mit.edu	37	13	24190168	24190168	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:24190168G>A	uc001uov.1	+	4	407	c.343G>A	c.(343-345)GGG>AGG	p.G115R	TNFRSF19_uc001uot.2_Missense_Mutation_p.G115R|TNFRSF19_uc010tcu.1_5'UTR|TNFRSF19_uc001uow.2_Missense_Mutation_p.G115R	NM_018647	NP_061117	Q9NS68	TNR19_HUMAN	tumor necrosis factor receptor superfamily,	115	Extracellular (Potential).				apoptosis|induction of apoptosis|JNK cascade	integral to membrane|mitochondrion	tumor necrosis factor receptor activity			kidney(1)|skin(1)	2		all_cancers(29;3.4e-22)|all_epithelial(30;8.75e-19)|all_lung(29;5.09e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00193)|Epithelial(112;0.0137)|OV - Ovarian serous cystadenocarcinoma(117;0.0465)|GBM - Glioblastoma multiforme(144;0.184)|Lung(94;0.19)		TGCCATCTGCGGGGACTGCTT	0.473000												
TRPC4	7223	broad.mit.edu	37	13	38211114	38211114	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:38211114C>A	uc001uws.2	-	11	3095	c.2860G>T	c.(2860-2862)GAC>TAC	p.D954Y	TRPC4_uc010abv.2_Missense_Mutation_p.D534Y|TRPC4_uc001uwt.2_Missense_Mutation_p.D870Y|TRPC4_uc010tey.1_Missense_Mutation_p.D813Y|TRPC4_uc010abw.2_Missense_Mutation_p.D781Y|TRPC4_uc010abx.2_Missense_Mutation_p.D959Y|TRPC4_uc010aby.2_Missense_Mutation_p.D805Y	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	954	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ATACTAGAGTCCTCTTCTTTT	0.443000												
TRPC4	7223	broad.mit.edu	37	13	38211582	38211582	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:38211582C>T	uc001uws.2	-	11	2627	c.2392G>A	c.(2392-2394)GAT>AAT	p.D798N	TRPC4_uc010abv.2_Missense_Mutation_p.D378N|TRPC4_uc001uwt.2_Intron|TRPC4_uc010tey.1_Intron|TRPC4_uc010abw.2_Missense_Mutation_p.D625N|TRPC4_uc010abx.2_Missense_Mutation_p.D803N|TRPC4_uc010aby.2_Intron	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	798	Binds to ITPR1, ITPR2 and ITPR3.|Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GTGGTTAAATCAAAAAGGCTG	0.463000												
ENOX1	55068	broad.mit.edu	37	13	43896599	43896599	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:43896599G>A	uc001uza.3	-	11	1482	c.1182C>T	c.(1180-1182)ATC>ATT	p.I394I	ENOX1_uc001uzb.3_Silent_p.I394I|ENOX1_uc001uzc.3_Silent_p.I394I|ENOX1_uc001uyz.3_Silent_p.I3I|ENOX1_uc010tfm.1_Silent_p.I207I	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	394					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CTTCGCGGCGGATGCCCATGA	0.473000												
PCDH17	27253	broad.mit.edu	37	13	58298909	58298909	+	Silent	SNP	C	C	T	rs138830034	byFrequency	TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:58298909C>T	uc001vhq.1	+	4	3853	c.2961C>T	c.(2959-2961)TAC>TAT	p.Y987Y	PCDH17_uc010aec.1_Silent_p.Y986Y|PCDH17_uc001vhr.1_Silent_p.Y76Y	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	987	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CTGAGACTTACGAAACTGTGA	0.413000												
TDRD3	81550	broad.mit.edu	37	13	61084866	61084866	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:61084866A>T	uc001via.2	+	10	1627	c.839A>T	c.(838-840)AAA>ATA	p.K280I	TDRD3_uc010aef.2_Missense_Mutation_p.K105I|TDRD3_uc001vhz.3_Missense_Mutation_p.K280I|TDRD3_uc010aeg.2_Missense_Mutation_p.K373I|TDRD3_uc001vib.3_Missense_Mutation_p.K279I	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	280					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		TTGGAATCTAAAATGGGAACT	0.323000												
DACH1	1602	broad.mit.edu	37	13	72440223	72440223	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:72440223G>A	uc010thn.1	-	2	1102	c.679C>T	c.(679-681)CAT>TAT	p.H227Y	DACH1_uc010tho.1_Missense_Mutation_p.H227Y|DACH1_uc010thp.1_Missense_Mutation_p.H227Y	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	227	Interaction with SIX6 and HDAC3 (By similarity).|DACHbox-N.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TAGACCGTATGCAAGCCCCCC	0.622000												
EDNRB	1910	broad.mit.edu	37	13	78477411	78477411	+	Silent	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:78477411C>A	uc001vko.2	-	3	939	c.681G>T	c.(679-681)GTG>GTT	p.V227V	EDNRB_uc001vkq.1_Silent_p.V227V|uc001vkn.1_Intron|EDNRB_uc010aez.1_Silent_p.V227V|EDNRB_uc001vkp.1_Silent_p.V310V	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	227	Helical; Name=4; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	CCACAGAGACCACCCAAATCA	0.408000												
SLITRK1	114798	broad.mit.edu	37	13	84454439	84454439	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr13:84454439T>G	uc001vlk.2	-	1	2090	c.1204A>C	c.(1204-1206)ATT>CTT	p.I402L		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	402	Extracellular (Potential).|LRR 8.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TCCAACAGAATGAGGTTCTTG	0.433000												
NPAS3	64067	broad.mit.edu	37	14	34269031	34269031	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:34269031G>A	uc001wru.2	+	12	1582	c.1518G>A	c.(1516-1518)GCG>GCA	p.A506A	NPAS3_uc001wrs.2_Silent_p.A493A|NPAS3_uc001wrt.2_Silent_p.A474A|NPAS3_uc001wrv.2_Silent_p.A476A	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CGGGCAACGCGTGTGACAACG	0.592000												
NIN	51199	broad.mit.edu	37	14	51224398	51224398	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:51224398C>T	uc001wym.2	-	18	3541	c.3350G>A	c.(3349-3351)GGA>GAA	p.G1117E	NIN_uc001wyi.2_Missense_Mutation_p.G1117E|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Missense_Mutation_p.G1123E|NIN_uc001wyo.2_Missense_Mutation_p.G1117E	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1117					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					CGCAGTATTTCCAAAAAACTC	0.433000			T	PDGFRB	MPD							
NIN	51199	broad.mit.edu	37	14	51224423	51224423	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:51224423C>G	uc001wym.2	-	18	3516	c.3325G>C	c.(3325-3327)GAT>CAT	p.D1109H	NIN_uc001wyi.2_Missense_Mutation_p.D1109H|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Missense_Mutation_p.D1115H|NIN_uc001wyo.2_Missense_Mutation_p.D1109H	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1109					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GCTGGCTCATCCAAACAAGAA	0.428000			T	PDGFRB	MPD							
NIN	51199	broad.mit.edu	37	14	51224605	51224605	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:51224605C>G	uc001wym.2	-	18	3334	c.3143G>C	c.(3142-3144)GGA>GCA	p.G1048A	NIN_uc001wyi.2_Missense_Mutation_p.G1048A|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Missense_Mutation_p.G1054A|NIN_uc001wyo.2_Missense_Mutation_p.G1048A	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	1048					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GGACAGGGCTCCATCTCCTTC	0.507000			T	PDGFRB	MPD							
NIN	51199	broad.mit.edu	37	14	51224813	51224813	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:51224813C>A	uc001wym.2	-	18	3126	c.2935G>T	c.(2935-2937)GAA>TAA	p.E979*	NIN_uc001wyi.2_Nonsense_Mutation_p.E979*|NIN_uc001wyj.2_Intron|NIN_uc001wyk.2_Intron|NIN_uc010tqp.1_Nonsense_Mutation_p.E985*|NIN_uc001wyo.2_Nonsense_Mutation_p.E979*	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	979	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TCCTGCCTTTCCTGGTCATGT	0.542000			T	PDGFRB	MPD							
KTN1	3895	broad.mit.edu	37	14	56107659	56107659	+	Silent	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:56107659T>A	uc001xcb.2	+	17	2294	c.1992T>A	c.(1990-1992)GCT>GCA	p.A664A	KTN1_uc001xce.2_Silent_p.A664A|KTN1_uc001xcc.2_Silent_p.A664A|KTN1_uc001xcd.2_Silent_p.A664A|KTN1_uc010trb.1_Silent_p.A664A|KTN1_uc001xcf.1_Silent_p.A664A	NM_182926	NP_891556	Q86UP2	KTN1_HUMAN	kinectin 1 isoform a	664	Lumenal (Potential).|Potential.				microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(3)|ovary(2)|lung(1)|central_nervous_system(1)	7						AGGCTGCTGCTGCACATGAAT	0.318000			T	RET	papillary thryoid							
ATP6V1D	51382	broad.mit.edu	37	14	67826414	67826414	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:67826414A>T	uc001xjf.2	-	1	178	c.2T>A	c.(1-3)ATG>AAG	p.M1K	ATP6V1D_uc001xje.2_RNA|EIF2S1_uc001xjg.2_5'Flank	NM_015994	NP_057078	Q9Y5K8	VATD_HUMAN	H(+)-transporting two-sector ATPase	1					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain|vacuolar proton-transporting V-type ATPase complex	protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)|lung(1)	2				all cancers(60;0.000739)|OV - Ovarian serous cystadenocarcinoma(108;0.00597)|BRCA - Breast invasive adenocarcinoma(234;0.00957)		TTTGCCCGACATTCTGACGAT	0.552000												
DPF3	8110	broad.mit.edu	37	14	73140966	73140966	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:73140966C>T	uc001xnc.2	-	8	866	c.853G>A	c.(853-855)GCA>ACA	p.A285T	DPF3_uc001xnd.1_RNA|DPF3_uc001xnf.2_RNA|DPF3_uc010ari.1_Missense_Mutation_p.A285T|DPF3_uc010ttq.1_Missense_Mutation_p.A295T	NM_012074	NP_036206	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	285	PHD-type 1.				chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		CCACAGTCTGCGCAGGACACC	0.572000												
CCDC88C	440193	broad.mit.edu	37	14	91780011	91780011	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:91780011G>A	uc010aty.2	-	15	2248	c.2149C>T	c.(2149-2151)CGC>TGC	p.R717C		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	717	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CTGGTGAAGCGCATGGTCTCC	0.607000												
BCL11B	64919	broad.mit.edu	37	14	99640530	99640530	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:99640530C>T	uc001yga.2	-	4	2910	c.2643G>A	c.(2641-2643)TTG>TTA	p.L881L	BCL11B_uc001ygb.2_Silent_p.L810L	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	881	C2H2-type 6.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CGTTAGTCAGCAAGTGCTCGC	0.483000			T	TLX3	T-ALL							
INF2	64423	broad.mit.edu	37	14	105180624	105180624	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr14:105180624G>A	uc001ypb.2	+	21	3268	c.3125G>A	c.(3124-3126)AGC>AAC	p.S1042N	INF2_uc010tyi.1_Missense_Mutation_p.S1042N|INF2_uc001ypc.2_Missense_Mutation_p.S1042N|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	1042					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		ACAACAGCCAGCGAGTCCCGG	0.687000												
MAP1A	4130	broad.mit.edu	37	15	43817620	43817620	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr15:43817620C>G	uc001zrt.2	+	4	4416	c.3949C>G	c.(3949-3951)CTG>GTG	p.L1317V		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1317						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TGAACACATTCTGACACCTGA	0.502000												
RFX7	64864	broad.mit.edu	37	15	56387980	56387980	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr15:56387980G>C	uc010bfn.2	-	9	1946	c.1946C>G	c.(1945-1947)CCT>CGT	p.P649R	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Missense_Mutation_p.P463R	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	552					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						GCATAATTTAGGGTCTTTATT	0.428000												
TLN2	83660	broad.mit.edu	37	15	63089448	63089448	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr15:63089448G>A	uc002alb.3	+	45	6081	c.6081G>A	c.(6079-6081)TTG>TTA	p.L2027L	TLN2_uc002alc.3_Silent_p.L420L	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2027					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CCAAGGCCTTGGTAGAAGACA	0.577000												
MYO9A	4649	broad.mit.edu	37	15	72302748	72302748	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr15:72302748A>C	uc002atl.3	-	7	1669	c.1196T>G	c.(1195-1197)TTT>TGT	p.F399C	MYO9A_uc010biq.2_5'UTR|MYO9A_uc002ato.2_Missense_Mutation_p.F399C|MYO9A_uc002atn.1_Missense_Mutation_p.F380C	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	399	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						TAGGCGCTCAAAGTCATGTCT	0.328000												
ACAN	176	broad.mit.edu	37	15	89400187	89400187	+	Silent	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr15:89400187A>G	uc010upo.1	+	12	4745	c.4371A>G	c.(4369-4371)CTA>CTG	p.L1457L	ACAN_uc010upp.1_Silent_p.L1457L|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1457					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GAGAAGTTCTAGAGACTTCTA	0.517000												
TPSG1	25823	broad.mit.edu	37	16	1272743	1272743	+	Silent	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr16:1272743C>G	uc002ckw.2	-	4	422	c.420G>C	c.(418-420)CGG>CGC	p.R140R		NM_012467	NP_036599	Q9NRR2	TRYG1_HUMAN	transmembrane tryptase preproprotein	140	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				CGGGCAGGATCCGGCTGGAGA	0.682000												
C16orf71	146562	broad.mit.edu	37	16	4790653	4790653	+	Missense_Mutation	SNP	C	C	T	rs144741586	byFrequency	TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr16:4790653C>T	uc002cxn.2	+	4	1238	c.776C>T	c.(775-777)TCG>TTG	p.S259L		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	259										central_nervous_system(1)	1						CCAGTGCTCTCGCTCCAGGTA	0.637000												
ACSM2A	123876	broad.mit.edu	37	16	20497938	20497938	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr16:20497938A>C	uc010bwe.2	+	15	1911	c.1672A>C	c.(1672-1674)ATT>CTT	p.I558L	ACSM2A_uc002dhf.3_Missense_Mutation_p.I558L|ACSM2A_uc002dhg.3_Missense_Mutation_p.I558L|ACSM2A_uc010vay.1_Missense_Mutation_p.I479L|ACSM2A_uc002dhh.3_Missense_Mutation_p.I188L|uc002dhi.1_5'Flank	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	558					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CACAGGGAAAATTCAACGAGC	0.473000												
ZNF668	79759	broad.mit.edu	37	16	31072937	31072937	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr16:31072937C>T	uc010caf.2	-	3	1669	c.1312G>A	c.(1312-1314)GTG>ATG	p.V438M	ZNF668_uc002eao.2_Missense_Mutation_p.V438M	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						TCACCTGCCACGCCCACAGGC	0.716000												
ITGAM	3684	broad.mit.edu	37	16	31332822	31332822	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr16:31332822T>G	uc002ebq.2	+	16	1974	c.1876T>G	c.(1876-1878)TTC>GTC	p.F626V	ITGAM_uc002ebr.2_Missense_Mutation_p.F627V|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_Missense_Mutation_p.F32V|ITGAM_uc002ebs.1_Missense_Mutation_p.F32V	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	626	Extracellular (Potential).|FG-GAP 7.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						AATCATGGAGTTCAATCCCAG	0.488000												
PSKH1	5681	broad.mit.edu	37	16	67943234	67943234	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr16:67943234C>T	uc002euv.2	+	2	752	c.582C>T	c.(580-582)GAC>GAT	p.D194D	PSKH1_uc010cet.2_Silent_p.D194D	NM_006742	NP_006733	P11801	KPSH1_HUMAN	protein serine kinase H1	194	Protein kinase.					endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|nuclear speck|plasma membrane	ATP binding|protein serine/threonine kinase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0044)|Epithelial(162;0.0197)|all cancers(182;0.128)		CCGAGCGTGACGCCACGCGGG	0.587000												
KARS	3735	broad.mit.edu	37	16	75662592	75662592	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr16:75662592C>T	uc002feq.2	-	13	1618	c.1570G>A	c.(1570-1572)GAT>AAT	p.D524N	KARS_uc002fer.2_Missense_Mutation_p.D552N|KARS_uc002fes.2_Missense_Mutation_p.D368N	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	524					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	ATGGCCTCATCATCACCTGCA	0.512000												
CNTNAP4	85445	broad.mit.edu	37	16	76486568	76486568	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr16:76486568T>C	uc002feu.1	+	10	1620	c.1235T>C	c.(1234-1236)CTT>CCT	p.L412P	CNTNAP4_uc002fev.1_Missense_Mutation_p.L276P|CNTNAP4_uc010chb.1_Missense_Mutation_p.L339P|CNTNAP4_uc002fex.1_Missense_Mutation_p.L415P|CNTNAP4_uc002few.2_Missense_Mutation_p.L387P	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	412	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TTCAGTGAACTTCAGCTGATT	0.458000												
SLC43A2	124935	broad.mit.edu	37	17	1489235	1489235	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:1489235C>T	uc002fsv.2	-	10	1278	c.1189G>A	c.(1189-1191)GAG>AAG	p.E397K	SLC43A2_uc002fsu.2_Missense_Mutation_p.E401K|SLC43A2_uc002fsw.2_Missense_Mutation_p.E397K|SLC43A2_uc002fsx.2_Missense_Mutation_p.E397K	NM_152346	NP_689559	Q8N370	LAT4_HUMAN	solute carrier family 43, member 2	397					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		TCGGGCTCCTCGGAGGCGTCT	0.652000												
SMG6	23293	broad.mit.edu	37	17	2203121	2203121	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:2203121A>G	uc002fub.1	-	2	981	c.926T>C	c.(925-927)ATT>ACT	p.I309T	SMG6_uc002fud.1_Missense_Mutation_p.I278T	NM_017575	NP_060045	Q86US8	EST1A_HUMAN	Smg-6 homolog, nonsense mediated mRNA decay	309	Interaction with telomeric DNA.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			central_nervous_system(2)|lung(1)|kidney(1)	4						AGGCTCATCAATTCTGTCCTC	0.512000												
TP53	7157	broad.mit.edu	37	17	7577120	7577120	+	Missense_Mutation	SNP	C	C	T	rs28934576	by1000genomes	TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:7577120C>T	uc002gim.2	-	8	1012	c.818G>A	c.(817-819)CGT>CAT	p.R273H	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141H|TP53_uc010cng.1_Missense_Mutation_p.R141H|TP53_uc002gii.1_Missense_Mutation_p.R141H|TP53_uc010cnh.1_Missense_Mutation_p.R273H|TP53_uc010cni.1_Missense_Mutation_p.R273H|TP53_uc002gij.2_Missense_Mutation_p.R273H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(469)|p.R273C(394)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCACAAACACGCACCTCAAA	0.542000	R273H(NCIH1793_LUNG)|R273H(MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PANC1_PANCREAS)|R273H(NCIH508_LARGE_INTESTINE)|R273H(NCIH1975_LUNG)|R273H(U251MG_CENTRAL_NERVOUS_SYSTEM)|R273H(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273H(NCIH2405_LUNG)|R273H(HEC59_ENDOMETRIUM)|R273H(NCIH1155_LUNG)|R273H(HT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(EN_ENDOMETRIUM)|R273H(SNB19_CENTRAL_NERVOUS_SYSTEM)|R273H(MDAMB468_BREAST)|R273H(SUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273H(SW620_LARGE_INTESTINE)|R273H(SUIT2_PANCREAS)|R273H(SW480_LARGE_INTESTINE)|R273H(SKMEL30_SKIN)|R273H(OC314_OVARY)|R273H(HEC6_ENDOMETRIUM)|R273H(HT29_LARGE_INTESTINE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
PFAS	5198	broad.mit.edu	37	17	8167849	8167849	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:8167849G>C	uc002gkr.2	+	17	2120	c.1979G>C	c.(1978-1980)AGC>ACC	p.S660T	PFAS_uc010vuv.1_Missense_Mutation_p.S236T|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	660					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCAGGGCTGAGCGTGCACCAG	0.647000												
DNAH9	1770	broad.mit.edu	37	17	11684386	11684386	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:11684386A>G	uc002gne.2	+	39	7681	c.7613A>G	c.(7612-7614)AAG>AGG	p.K2538R	DNAH9_uc010coo.2_Missense_Mutation_p.K1832R	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2538	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CCAGGGAACAAGAAACTCATC	0.552000												
RAB34	83871	broad.mit.edu	37	17	27043058	27043058	+	Silent	SNP	G	G	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:27043058G>T	uc002hce.2	-	3	789	c.165C>A	c.(163-165)GTC>GTA	p.V55V	RAB34_uc002hcg.2_Silent_p.V55V|RAB34_uc002hcf.2_Silent_p.V56V|RAB34_uc010was.1_Silent_p.V112V|RAB34_uc010wat.1_Silent_p.V112V|RAB34_uc002hch.2_Silent_p.V55V|RAB34_uc010wau.1_Intron|RAB34_uc010wav.1_Silent_p.V113V	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1	55				V -> I (in Ref. 3; BAC11141).	protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					CCACCACAATGACCTTGGAGA	0.582000												
MYO18A	399687	broad.mit.edu	37	17	27493224	27493224	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:27493224G>A	uc002hdt.1	-	2	893	c.735C>T	c.(733-735)CCC>CCT	p.P245P	MYO18A_uc010csa.1_Silent_p.P245P|MYO18A_uc002hdu.1_Silent_p.P245P	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	245	PDZ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CCTGGCCCTCGGGGCCCCGAT	0.682000												
EFCAB5	374786	broad.mit.edu	37	17	28418902	28418902	+	Silent	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:28418902C>G	uc002het.2	+	21	4143	c.3951C>G	c.(3949-3951)GTC>GTG	p.V1317V	EFCAB5_uc010cse.2_Silent_p.V1072V|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1317							calcium ion binding			ovary(1)|skin(1)	2						TTGAAAATGTCAGGGAAGTCC	0.398000												
EVI2A	2123	broad.mit.edu	37	17	29646016	29646016	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:29646016C>T	uc002hgm.2	-	2	231	c.16G>A	c.(16-18)GAA>AAA	p.E6K	NF1_uc002hgg.2_Intron|NF1_uc002hgh.2_Intron|NF1_uc002hgi.1_Intron|NF1_uc010cso.2_Intron|EVI2A_uc002hgl.2_Missense_Mutation_p.E29K	NM_014210	NP_055025	P22794	EVI2A_HUMAN	ecotropic viral integration site 2A isoform 2	6						integral to membrane	transmembrane receptor activity			ovary(1)|breast(1)	2		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;5.94e-13)|Epithelial(4;7.98e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.4e-12)|GBM - Glioblastoma multiforme(4;0.18)		CCTGTGTGTTCCATGTCCGTG	0.393000												
MMD	23531	broad.mit.edu	37	17	53481221	53481221	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr17:53481221A>C	uc002iui.2	-	5	638	c.353T>G	c.(352-354)CTT>CGT	p.L118R		NM_012329	NP_036461	Q15546	PAQRB_HUMAN	monocyte to macrophage	118	Helical; (Potential).				cytolysis	integral to plasma membrane|late endosome membrane|lysosomal membrane|membrane fraction	receptor activity				0						AAGTTCACGAAGATTTAACCT	0.388000												
ENOSF1	55556	broad.mit.edu	37	18	677406	677406	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr18:677406C>A	uc002kku.3	-	14	1162	c.1087G>T	c.(1087-1089)GAA>TAA	p.E363*	ENOSF1_uc002kkt.3_Nonsense_Mutation_p.E281*|ENOSF1_uc010dke.2_RNA|ENOSF1_uc010dkf.2_Nonsense_Mutation_p.E370*|ENOSF1_uc002kkv.3_Nonsense_Mutation_p.E350*|ENOSF1_uc002kkw.3_Nonsense_Mutation_p.E182*|ENOSF1_uc002kkx.3_Nonsense_Mutation_p.E287*	NM_017512	NP_059982	Q7L5Y1	ENOF1_HUMAN	enolase superfamily 1 isoform rTS beta	363					cellular amino acid catabolic process	mitochondrion	isomerase activity|metal ion binding			ovary(1)	1						TGCACCAGTTCACAGAGGCCA	0.438000												
L3MBTL4	91133	broad.mit.edu	37	18	6093528	6093528	+	Splice_Site	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr18:6093528C>A	uc002kmz.3	-	15	1360	c.1200_splice	c.e15-1	p.S400_splice	L3MBTL4_uc010dkt.2_Splice_Site_p.S400_splice|L3MBTL4_uc002kmy.3_Splice_Site_p.S238_splice	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4						chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				GCCAAAAGCACTGGTTTGTAT	0.383000												
PTPRM	5797	broad.mit.edu	37	18	8376482	8376482	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr18:8376482T>A	uc002knn.3	+	24	3813	c.3310T>A	c.(3310-3312)TGT>AGT	p.C1104S	PTPRM_uc010dkv.2_Missense_Mutation_p.C1117S|PTPRM_uc010wzl.1_Missense_Mutation_p.C891S	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1104	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GAGGACTGGCTGTTTCATCGT	0.493000												
NPC1	4864	broad.mit.edu	37	18	21124371	21124371	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr18:21124371G>A	uc002kum.3	-	13	2341	c.2067C>T	c.(2065-2067)GTC>GTT	p.V689V	NPC1_uc010xaz.1_Silent_p.V422V|NPC1_uc010xba.1_Silent_p.V534V	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	689	SSD.|Helical; (Potential).				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GGAACGGGATGACTTCAATCA	0.527000												
FAM59A	64762	broad.mit.edu	37	18	29867375	29867375	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr18:29867375G>A	uc002kxl.2	-	4	1241	c.1185C>T	c.(1183-1185)CTC>CTT	p.L395L	FAM59A_uc002kxk.1_Silent_p.L395L	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	395										ovary(1)|skin(1)	2						TGTTGCCATGGAGATTGTTGC	0.572000												
ONECUT2	9480	broad.mit.edu	37	18	55143752	55143752	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr18:55143752C>T	uc002lgo.2	+	2	1344	c.1312C>T	c.(1312-1314)CGC>TGC	p.R438C		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	438	Homeobox.				organ morphogenesis	nucleus	sequence-specific DNA binding	p.R438C(1)		ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		TGACCTCCAACGCCGAACACT	0.522000												
ZNF236	7776	broad.mit.edu	37	18	74607072	74607072	+	Silent	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr18:74607072C>A	uc002lmi.2	+	10	1713	c.1515C>A	c.(1513-1515)ACC>ACA	p.T505T	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	505					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GCATCCACACCCACGAGAAGC	0.642000												
ZNF236	7776	broad.mit.edu	37	18	74607093	74607093	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr18:74607093C>G	uc002lmi.2	+	10	1734	c.1536C>G	c.(1534-1536)TGC>TGG	p.C512W	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	512	C2H2-type 11.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CCTTCAAGTGCCCGCAGTGCT	0.617000												
REXO1	57455	broad.mit.edu	37	19	1816466	1816466	+	Silent	SNP	G	G	A	rs144308719	byFrequency	TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:1816466G>A	uc002lua.3	-	14	3515	c.3420C>T	c.(3418-3420)ATC>ATT	p.I1140I	REXO1_uc010dsq.2_Silent_p.I449I|REXO1_uc010xgs.1_Silent_p.I126I|MIR1909_hsa-mir-1909|MI0008330_5'Flank	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	1140	Exonuclease.					nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGTGTCCGATGAGGATGG	0.672000												
FEM1A	55527	broad.mit.edu	37	19	4793212	4793212	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:4793212G>A	uc002mbf.2	+	1	1485	c.1346G>A	c.(1345-1347)CGG>CAG	p.R449Q	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	449					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CTTCAGGACCGGGCCGCCAAA	0.642000												
TMEM146	257062	broad.mit.edu	37	19	5778566	5778566	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:5778566C>T	uc002mda.2	+	22	2337	c.2276C>T	c.(2275-2277)GCG>GTG	p.A759V		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	759	Cytoplasmic (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						AAGAAGTGTGCGACACAGCTG	0.627000												
HNRNPM	4670	broad.mit.edu	37	19	8536272	8536272	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:8536272C>T	uc010dwe.2	+	10	1038	c.958C>T	c.(958-960)CTG>TTG	p.L320L	HNRNPM_uc010dwc.1_Silent_p.L320L|HNRNPM_uc010xke.1_Silent_p.L281L|HNRNPM_uc010dwd.2_Silent_p.L281L|HNRNPM_uc002mka.2_Silent_p.L200L	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	320					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						TGCCAATCACCTGAATAAAGG	0.463000												
TPM4	7171	broad.mit.edu	37	19	16204371	16204371	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:16204371A>G	uc002ndj.2	+	6	798	c.557A>G	c.(556-558)GAA>GGA	p.E186G	TPM4_uc002ndi.2_Missense_Mutation_p.E222G|TPM4_uc002ndk.1_Missense_Mutation_p.E96G	NM_003290	NP_003281	P67936	TPM4_HUMAN	tropomyosin 4 isoform 2	186	By similarity.				cellular component movement|muscle filament sliding|response to oxidative stress	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding|calcium ion binding|structural constituent of muscle		TPM4/ALK(12)	soft_tissue(10)|haematopoietic_and_lymphoid_tissue(2)|breast(1)	13						GACAAATATGAAGAAGAAATT	0.383000			T	ALK	ALCL							
ZNF536	9745	broad.mit.edu	37	19	31040415	31040415	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:31040415T>G	uc002nsu.1	+	4	4027	c.3889T>G	c.(3889-3891)TTG>GTG	p.L1297V	ZNF536_uc010edd.1_Missense_Mutation_p.L1297V	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GAGGCCAGACTTGTGTGGTAA	0.428000												
TSHZ3	57616	broad.mit.edu	37	19	31769778	31769778	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:31769778T>G	uc002nsy.3	-	2	986	c.921A>C	c.(919-921)GAA>GAC	p.E307D		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	307					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GAGTGACGGGTTCCTTCAGAG	0.532000												
ZNF574	64763	broad.mit.edu	37	19	42585010	42585010	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:42585010C>T	uc002osm.3	+	2	2421	c.2252C>T	c.(2251-2253)ACG>ATG	p.T751M	ZNF574_uc002osk.3_Missense_Mutation_p.T841M	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	751	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				AGCACAGAGACGTCACTGCAG	0.627000												
RTN2	6253	broad.mit.edu	37	19	45997476	45997476	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:45997476C>T	uc002pcb.2	-	4	990	c.762G>A	c.(760-762)CAG>CAA	p.Q254Q	RTN2_uc002pcc.2_Silent_p.Q254Q|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	254						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		TATCGAGGCACTGTCCCCTTA	0.552000												
QPCTL	54814	broad.mit.edu	37	19	46195984	46195984	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:46195984G>C	uc010xxr.1	+	1	244	c.23G>C	c.(22-24)CGA>CCA	p.R8P	SNRPD2_uc002pcv.2_5'Flank|SNRPD2_uc002pcw.2_5'Flank|QPCTL_uc010ekn.2_Missense_Mutation_p.R8P	NM_017659	NP_060129	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like isoform	8					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		GGCCGCGGGCGACCCCGCCTG	0.672000												
ZNF613	79898	broad.mit.edu	37	19	52447732	52447732	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:52447732A>T	uc002pxz.1	+	6	1019	c.596A>T	c.(595-597)AAC>ATC	p.N199I	ZNF613_uc002pya.1_Missense_Mutation_p.N163I	NM_001031721	NP_001026891	Q6PF04	ZN613_HUMAN	zinc finger protein 613 isoform 1	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		CGAACTCAAAACATAGATAAA	0.413000												
ZNF347	84671	broad.mit.edu	37	19	53643983	53643983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:53643983G>A	uc002qbb.1	-	5	2167	c.2098C>T	c.(2098-2100)CAG>TAG	p.Q700*	ZNF347_uc010eql.1_Nonsense_Mutation_p.Q701*|ZNF347_uc002qbc.1_Nonsense_Mutation_p.Q701*	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	700	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TGAACTCTCTGATGCCTTGCA	0.443000												
NLRP8	126205	broad.mit.edu	37	19	56466706	56466706	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:56466706G>A	uc002qmh.2	+	3	1353	c.1282G>A	c.(1282-1284)GTC>ATC	p.V428I	NLRP8_uc010etg.2_Missense_Mutation_p.V428I	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	428	NACHT.					cytoplasm	ATP binding	p.V428I(1)		ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTCTGTGTTCGTCCGGTATAT	0.498000												
ZNF550	162972	broad.mit.edu	37	19	58059343	58059343	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:58059343T>C	uc002qpe.1	-	2	146	c.146A>G	c.(145-147)CAT>CGT	p.H49R	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTCTCTGGTATGAACTTGTGC	0.453000												
MYT1L	23040	broad.mit.edu	37	2	1926913	1926913	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:1926913T>C	uc002qxe.2	-	10	1455	c.628A>G	c.(628-630)AAA>GAA	p.K210E	MYT1L_uc002qxd.2_Missense_Mutation_p.K210E|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	210					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCAGCGATTTTGCCGAGGTTT	0.423000												
FAM98A	25940	broad.mit.edu	37	2	33817259	33817259	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:33817259G>C	uc002rpa.1	-	3	299	c.225C>G	c.(223-225)TTC>TTG	p.F75L	FAM98A_uc010yne.1_5'UTR	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	75										ovary(1)	1	all_hematologic(175;0.115)					CCTCAAGCTGGAATTCTTCAG	0.378000												
AAK1	22848	broad.mit.edu	37	2	69870090	69870090	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:69870090G>A	uc002sfp.2	-	2	588	c.83C>T	c.(82-84)TCG>TTG	p.S28L	AAK1_uc010fdk.2_Missense_Mutation_p.S28L|AAK1_uc010yqm.1_Missense_Mutation_p.S28L|AAK1_uc010fdm.1_Missense_Mutation_p.S28L	NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	28	Gly-rich.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0						GCCCAGGCCCGAGGTGCTGCC	0.647000												
C2orf42	54980	broad.mit.edu	37	2	70377631	70377631	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:70377631G>C	uc002sgh.2	-	10	1910	c.1582C>G	c.(1582-1584)CCC>GCC	p.P528A		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	hypothetical protein LOC54980	528											0						TTAGATTGGGGAAGGATATCT	0.512000												
SEMA4F	10505	broad.mit.edu	37	2	74900920	74900920	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:74900920C>T	uc002sna.1	+	7	898	c.787C>T	c.(787-789)CGC>TGC	p.R263C	SEMA4F_uc010ysb.1_3'UTR|SEMA4F_uc010ffq.1_Missense_Mutation_p.R230C|SEMA4F_uc010ffr.1_Intron|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Intron	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	263	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CTCATACGAGCGCATTAAAGT	0.552000												
AFF3	3899	broad.mit.edu	37	2	100623915	100623915	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:100623915T>A	uc002tag.2	-	5	418	c.182A>T	c.(181-183)AAG>ATG	p.K61M	AFF3_uc002taf.2_Missense_Mutation_p.K86M|AFF3_uc010fiq.1_Missense_Mutation_p.K61M|AFF3_uc010yvr.1_Missense_Mutation_p.K215M|AFF3_uc002tah.1_Missense_Mutation_p.K86M|AFF3_uc010fir.1_Missense_Mutation_p.K138M|AFF3_uc002tai.2_Translation_Start_Site	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	61					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TTCATCCCCCTTGTTAGTCTG	0.423000												
RANBP2	5903	broad.mit.edu	37	2	109380603	109380603	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:109380603G>A	uc002tem.3	+	20	3734	c.3608G>A	c.(3607-3609)CGT>CAT	p.R1203H		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1203	RanBD1 1.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AAATTGTTTCGTTTCGATGTA	0.393000												
DPP10	57628	broad.mit.edu	37	2	116548896	116548896	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:116548896T>G	uc002tla.1	+	19	2121	c.1664T>G	c.(1663-1665)TTT>TGT	p.F555C	DPP10_uc002tlb.1_Missense_Mutation_p.F505C|DPP10_uc002tlc.1_Missense_Mutation_p.F551C|DPP10_uc002tle.2_Missense_Mutation_p.F559C|DPP10_uc002tlf.1_Missense_Mutation_p.F548C	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	555	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CCCAAAGATTTTATGGACCGA	0.299000												
LCT	3938	broad.mit.edu	37	2	136575081	136575081	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:136575081C>T	uc002tuu.1	-	6	1548	c.1537G>A	c.(1537-1539)GAG>AAG	p.E513K		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	513	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		ACCACGCTCTCATTCTGCCAT	0.597000												
SPOPL	339745	broad.mit.edu	37	2	139326627	139326627	+	Missense_Mutation	SNP	C	C	T	rs142534399	by1000genomes	TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:139326627C>T	uc002tvh.2	+	11	1556	c.1156C>T	c.(1156-1158)CGC>TGC	p.R386C		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	386						nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		TGGCATTCCACGCAAACGGCT	0.443000												
ZEB2	9839	broad.mit.edu	37	2	145156214	145156214	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:145156214T>G	uc002tvu.2	-	8	3020	c.2540A>C	c.(2539-2541)AAC>ACC	p.N847T	ZEB2_uc002tvv.2_Missense_Mutation_p.N841T|ZEB2_uc010zbm.1_Missense_Mutation_p.N818T|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.N876T	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	847						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		AGAAACACTGTTATGATCTAA	0.338000												
GRB14	2888	broad.mit.edu	37	2	165365252	165365252	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:165365252C>T	uc002ucl.2	-	7	1468	c.927G>A	c.(925-927)AAG>AAA	p.K309K	GRB14_uc010zcv.1_Silent_p.K222K|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	309	PH.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						AAGCCTGTACCTTAAAGCAGA	0.363000												
WIPF1	7456	broad.mit.edu	37	2	175437098	175437098	+	Silent	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:175437098A>G	uc002uiy.2	-	6	767	c.435T>C	c.(433-435)AGT>AGC	p.S145S	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Silent_p.S145S|WIPF1_uc010fqt.1_Silent_p.S145S|WIPF1_uc002ujc.1_Silent_p.S145S|WIPF1_uc002uiz.2_Silent_p.S145S|WIPF1_uc002ujb.1_Silent_p.S145S|WIPF1_uc010zep.1_Silent_p.S145S	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	145					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						TCCCTGGGCCACTTGGGGGTG	0.582000												
HOXD10	3236	broad.mit.edu	37	2	176983843	176983843	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:176983843G>A	uc002ukj.2	+	2	977	c.907G>A	c.(907-909)GTT>ATT	p.V303I		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	303	Homeobox.					nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CAGTAAGAGCGTTAACCTCAC	0.498000												
ZNF804A	91752	broad.mit.edu	37	2	185801262	185801262	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:185801262T>G	uc002uph.2	+	4	1733	c.1139T>G	c.(1138-1140)GTT>GGT	p.V380G		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	380						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAGGAAAATGTTAAGCATAAC	0.383000												
CDK15	65061	broad.mit.edu	37	2	202672278	202672278	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:202672278C>T	uc002uyt.2	+	2	234	c.185C>T	c.(184-186)GCT>GTT	p.A62V	CDK15_uc010ftm.2_5'UTR|CDK15_uc002uys.2_Missense_Mutation_p.A11V|CDK15_uc010ftn.1_Missense_Mutation_p.A11V|CDK15_uc010fto.1_Missense_Mutation_p.A62V	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	62							ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	GGACTTCAAGCTGCCCGTGCC	0.443000												
INO80D	54891	broad.mit.edu	37	2	206892937	206892937	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:206892937C>T	uc002vaz.3	-	6	1601	c.1196G>A	c.(1195-1197)CGG>CAG	p.R399Q		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	399					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						AAACGTATGCCGGCATTTCTT	0.502000												
ERBB4	2066	broad.mit.edu	37	2	212251754	212251754	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:212251754A>C	uc002veg.1	-	27	3403	c.3305T>G	c.(3304-3306)TTT>TGT	p.F1102C	ERBB4_uc002veh.1_Missense_Mutation_p.F1086C|ERBB4_uc010zji.1_Missense_Mutation_p.F1092C|ERBB4_uc010zjj.1_Missense_Mutation_p.F1076C	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1102	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GGAGTCATCAAAAATCTCAGC	0.547000										TSP Lung(8;0.080)		
SMARCAL1	50485	broad.mit.edu	37	2	217279594	217279594	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr2:217279594A>G	uc002vgc.3	+	3	497	c.167A>G	c.(166-168)AAT>AGT	p.N56S	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.N56S|SMARCAL1_uc010fvg.2_Missense_Mutation_p.N56S	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	56					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCATCCCAAAATTTCCCAAGG	0.502000									Schimke_Immuno-Osseous_Dysplasia			
LRRN4	164312	broad.mit.edu	37	20	6022187	6022187	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr20:6022187G>C	uc002wmo.2	-	5	1928	c.1704C>G	c.(1702-1704)TGC>TGG	p.C568W		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	568	Extracellular (Potential).					integral to membrane				skin(3)	3						CGGGGCACCGGCACCGCCACC	0.697000												
POFUT1	23509	broad.mit.edu	37	20	30803221	30803221	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr20:30803221G>A	uc002wxp.2	+	3	445	c.396G>A	c.(394-396)CAG>CAA	p.Q132Q	POFUT1_uc002wxo.2_Silent_p.Q132Q|POFUT1_uc010ztt.1_Silent_p.Q24Q|POFUT1_uc010ztu.1_Intron	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	132					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TGGCAGCCCAGCGAAGCCCAG	0.592000												
MYH7B	57644	broad.mit.edu	37	20	33585431	33585431	+	Silent	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr20:33585431G>C	uc002xbi.1	+	30	3953	c.3861G>C	c.(3859-3861)CTG>CTC	p.L1287L		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1245	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TGGAGACTCTGACCCGCGCCA	0.612000												
ATP9A	10079	broad.mit.edu	37	20	50238633	50238633	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr20:50238633C>T	uc002xwg.1	-	19	2095	c.2095G>A	c.(2095-2097)GAC>AAC	p.D699N	ATP9A_uc010gih.1_Missense_Mutation_p.D563N|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	699	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						ACGTGGATGTCTTGGTTTCTG	0.517000												
APP	351	broad.mit.edu	37	21	27347518	27347518	+	Silent	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr21:27347518A>G	uc002ylz.2	-	11	1523	c.1323T>C	c.(1321-1323)TCT>TCC	p.S441S	APP_uc010glk.2_Silent_p.S417S|APP_uc002yma.2_Silent_p.S422S|APP_uc011ach.1_Silent_p.S385S|APP_uc002ymb.2_Silent_p.S366S|APP_uc010glj.2_Silent_p.S310S|APP_uc011aci.1_Silent_p.S331S	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	441	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				CCTGTTCCAAAGATTCCACTT	0.498000												
KRTAP13-3	337960	broad.mit.edu	37	21	31797958	31797958	+	Silent	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr21:31797958A>G	uc002yob.1	-	1	273	c.273T>C	c.(271-273)TCT>TCC	p.S91S		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	91	5 X 10 AA approximate repeats.					intermediate filament				ovary(1)|lung(1)	2						TAGTCAGGCAAGAATTGCAGA	0.567000												
TIAM1	7074	broad.mit.edu	37	21	32493072	32493072	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr21:32493072C>T	uc002yow.1	-	29	4862	c.4390G>A	c.(4390-4392)GCA>ACA	p.A1464T	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Missense_Mutation_p.A1404T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1464					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GGGCTGCTTGCGGAGACGGCA	0.577000												
DSCAM	1826	broad.mit.edu	37	21	42080477	42080477	+	Silent	SNP	A	A	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr21:42080477A>C	uc002yyq.1	-	2	716	c.264T>G	c.(262-264)CCT>CCG	p.P88P	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	88	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGAAGCTTGAAGGAGGGAAGG	0.498000												
TRMT2A	27037	broad.mit.edu	37	22	20103938	20103938	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr22:20103938T>C	uc002zrk.1	-	3	437	c.222A>G	c.(220-222)AAA>AAG	p.K74K	TRMT2A_uc002zrl.1_Silent_p.K74K|TRMT2A_uc002zrm.1_5'UTR|TRMT2A_uc002zrn.1_Silent_p.K74K|TRMT2A_uc011ahk.1_Silent_p.K74K|RANBP1_uc011ahl.1_5'Flank|RANBP1_uc002zro.1_5'Flank|RANBP1_uc002zrp.2_5'Flank	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	74	RRM.				RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						GCAGCTCCAGTTTAAAGATCT	0.612000												
TRMT2A	27037	broad.mit.edu	37	22	20103951	20103951	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr22:20103951G>T	uc002zrk.1	-	3	424	c.209C>A	c.(208-210)TCT>TAT	p.S70Y	TRMT2A_uc002zrl.1_Missense_Mutation_p.S70Y|TRMT2A_uc002zrm.1_Translation_Start_Site|TRMT2A_uc002zrn.1_Missense_Mutation_p.S70Y|TRMT2A_uc011ahk.1_Missense_Mutation_p.S70Y|RANBP1_uc011ahl.1_5'Flank|RANBP1_uc002zro.1_5'Flank|RANBP1_uc002zrp.2_5'Flank	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	70					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						AAAGATCTCAGAGGTAAACAA	0.632000												
CNTN6	27255	broad.mit.edu	37	3	1269633	1269633	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr3:1269633T>G	uc003boz.2	+	4	581	c.314T>G	c.(313-315)CTT>CGT	p.L105R	CNTN6_uc010hbo.2_Missense_Mutation_p.L100R|CNTN6_uc011asj.1_Missense_Mutation_p.L33R|CNTN6_uc003bpa.2_Missense_Mutation_p.L105R	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	105	Ig-like C2-type 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GCCACCAATCTTCTGGGGACA	0.423000												
CNTN4	152330	broad.mit.edu	37	3	2908441	2908441	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr3:2908441A>G	uc003bpc.2	+	7	681	c.460A>G	c.(460-462)AGT>GGT	p.S154G	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Missense_Mutation_p.S154G	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	154	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TTCAGAGCTGAGTTATGCCTG	0.353000												
IQSEC1	9922	broad.mit.edu	37	3	12977720	12977720	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr3:12977720C>G	uc003bxt.2	-	3	847	c.838G>C	c.(838-840)GAA>CAA	p.E280Q	IQSEC1_uc003bxu.3_Missense_Mutation_p.E158Q|IQSEC1_uc011auw.1_Missense_Mutation_p.E266Q	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	280					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						GTCTGGGGTTCGGTGTCCCGG	0.637000												
ULK4	54986	broad.mit.edu	37	3	41938397	41938397	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr3:41938397G>A	uc003ckv.3	-	15	1648	c.1447C>T	c.(1447-1449)CGA>TGA	p.R483*	ULK4_uc003ckw.2_Nonsense_Mutation_p.R483*|ULK4_uc003ckx.1_Nonsense_Mutation_p.R483*	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	483							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGCTTGGCTCGGGAGGCCCCC	0.512000												
QRICH1	54870	broad.mit.edu	37	3	49094328	49094329	+	Missense_Mutation	DNP	CT	CT	TG			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr3:49094328_49094329CT>TG	uc010hkq.2	-	4	1600_1601	c.1304_1305AG>CA	c.(1303-1305)CAG>CCA	p.Q435P	QRICH1_uc003cvu.2_Missense_Mutation_p.Q435P|QRICH1_uc003cvv.2_Missense_Mutation_p.Q435P	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	435	Gln-rich.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		gctgctgctgctgtggtggtgg	0.361000												
ACTR8	93973	broad.mit.edu	37	3	53909990	53909990	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr3:53909990G>C	uc003dhd.2	-	7	955	c.896C>G	c.(895-897)TCT>TGT	p.S299C	ACTR8_uc003dhb.2_Missense_Mutation_p.S49C|ACTR8_uc003dhc.2_Missense_Mutation_p.S188C	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	299					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		ATTCCGATGAGACACCCCATC	0.463000												
IMPG2	50939	broad.mit.edu	37	3	100951814	100951814	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr3:100951814T>A	uc003duq.1	-	15	3247	c.3044A>T	c.(3043-3045)AAG>ATG	p.K1015M	IMPG2_uc011bhe.1_Missense_Mutation_p.K878M|IMPG2_uc010hpj.1_RNA	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1015	Extracellular (Potential).|EGF-like 1.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGCCTGAAACTTGCAAGGGTT	0.433000												
BCHE	590	broad.mit.edu	37	3	165547928	165547928	+	Missense_Mutation	SNP	T	T	G	rs138271111		TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr3:165547928T>G	uc003fem.3	-	2	1054	c.894A>C	c.(892-894)CAA>CAC	p.Q298H	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	298					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	GAAGAATTTCTTGGGGATCTT	0.408000												
ZBTB49	166793	broad.mit.edu	37	4	4303731	4303731	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr4:4303731T>A	uc003ghu.2	+	3	343	c.168T>A	c.(166-168)AAT>AAA	p.N56K	ZBTB49_uc003ghv.2_Intron|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_5'Flank	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	56	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TCTTTCAGAATTCTTCAAGCC	0.318000												
PPP2R2C	5522	broad.mit.edu	37	4	6374386	6374386	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr4:6374386G>C	uc003gjc.2	-	5	859	c.489C>G	c.(487-489)AGC>AGG	p.S163R	PPP2R2C_uc003gjb.2_Missense_Mutation_p.S146R|PPP2R2C_uc011bwd.1_Missense_Mutation_p.S156R|PPP2R2C_uc011bwe.1_Missense_Mutation_p.S156R|PPP2R2C_uc003gja.2_Missense_Mutation_p.S163R|PPP2R2C_uc003gjd.1_Missense_Mutation_p.S251R	NM_020416	NP_065149	Q9Y2T4	2ABG_HUMAN	gamma isoform of regulatory subunit B55, protein	163					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						TCCTCCGAGGGCTCACCTCCA	0.577000												
SLIT2	9353	broad.mit.edu	37	4	20618698	20618698	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr4:20618698A>T	uc003gpr.1	+	35	4217	c.4013A>T	c.(4012-4014)AAG>ATG	p.K1338M	SLIT2_uc003gps.1_Missense_Mutation_p.K1330M	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1338	EGF-like 7.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						CCATGCCACAAGAAGGTGTGT	0.597000												
LRRC66	339977	broad.mit.edu	37	4	52883456	52883456	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr4:52883456T>C	uc003gzi.2	-	1	337	c.324A>G	c.(322-324)TTA>TTG	p.L108L		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	108						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CCAAAGCATGTAAATATGCAA	0.403000												
HADH	3033	broad.mit.edu	37	4	108940820	108940820	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr4:108940820G>T	uc003hyq.2	+	4	693	c.544G>T	c.(544-546)GAG>TAG	p.E182*	HADH_uc010ilx.2_Nonsense_Mutation_p.E182*|HADH_uc010ily.2_Nonsense_Mutation_p.E5*|HADH_uc003hyr.2_Nonsense_Mutation_p.E186*	NM_005327	NP_005318	Q16836	HCDH_HUMAN	L-3-hydroxyacyl-Coenzyme A dehydrogenase	182					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	GAAACTTGTGGAGGTCAGTGG	0.532000												
FAT4	79633	broad.mit.edu	37	4	126412149	126412149	+	Silent	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr4:126412149T>A	uc003ifj.3	+	17	14172	c.14172T>A	c.(14170-14172)CCT>CCA	p.P4724P	FAT4_uc011cgp.1_Silent_p.P2965P|FAT4_uc003ifi.1_Silent_p.P2201P	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4724	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGCATCTTCCTATAAGGGATG	0.493000												
ZDHHC11	79844	broad.mit.edu	37	5	837555	837555	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr5:837555G>A	uc011cma.1	-	6	1209	c.825C>T	c.(823-825)AAC>AAT	p.N275N	ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	275						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			CTTCTTTGCGGTTATTAATGA	0.488000												
C6	729	broad.mit.edu	37	5	41149516	41149516	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr5:41149516T>G	uc003jmk.2	-	17	2660	c.2450A>C	c.(2449-2451)AAG>ACG	p.K817T	C6_uc003jml.1_Missense_Mutation_p.K817T	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	817	C5b-binding domain.|Complement control factor I module 1.|Kazal-like 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding	p.K817R(1)		ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AGCCAAAAACTTACAAGCGGG	0.423000												
MAP1B	4131	broad.mit.edu	37	5	71495786	71495786	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr5:71495786C>T	uc003kbw.3	+	5	6845	c.6604C>T	c.(6604-6606)CCA>TCA	p.P2202S	MAP1B_uc010iyw.1_Missense_Mutation_p.P2219S|MAP1B_uc010iyx.1_Missense_Mutation_p.P2076S|MAP1B_uc010iyy.1_Missense_Mutation_p.P2076S	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2202						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GGACCCACCTCCAGCTCCCGT	0.587000												
SLCO6A1	133482	broad.mit.edu	37	5	101834337	101834337	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr5:101834337T>C	uc003knn.2	-	1	384	c.212A>G	c.(211-213)AAG>AGG	p.K71R	SLCO6A1_uc003kno.2_Missense_Mutation_p.K71R|SLCO6A1_uc003knp.2_Missense_Mutation_p.K71R|SLCO6A1_uc003knq.2_Missense_Mutation_p.K71R	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	71	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AACTGAGGACTTGGCTTTTTT	0.517000												
PCDHB7	56129	broad.mit.edu	37	5	140553947	140553947	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr5:140553947G>A	uc003lit.2	+	1	1705	c.1531G>A	c.(1531-1533)GGC>AGC	p.G511S		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	511	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCGGACAACGGCCACCTGTT	0.692000												
SH3PXD2B	285590	broad.mit.edu	37	5	171766824	171766824	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr5:171766824T>C	uc003mbr.2	-	13	1456	c.1285A>G	c.(1285-1287)AGC>GGC	p.S429G		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	429					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GACGCGTTGCTCGTCTTCTTG	0.582000												
HIST1H3G	8355	broad.mit.edu	37	6	26271499	26271499	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:26271499T>C	uc003nhi.2	-	1	114	c.114A>G	c.(112-114)AAA>AAG	p.K38K	uc003nhj.2_5'Flank|HIST1H2BI_uc003nhk.2_5'Flank	NM_003534	NP_003525	P68431	H31_HUMAN	H3 histone family, member H	38					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding				0						AGCGATGAGGTTTCTTCACGC	0.647000												
ZNF323	64288	broad.mit.edu	37	6	28294500	28294500	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:28294500G>A	uc003nla.2	-	4	1064	c.664C>T	c.(664-666)CGA>TGA	p.R222*	ZNF323_uc003nld.2_Nonsense_Mutation_p.R222*|ZNF323_uc010jra.2_Nonsense_Mutation_p.R222*|ZNF323_uc003nlb.2_Nonsense_Mutation_p.R63*|ZNF323_uc010jrb.2_Nonsense_Mutation_p.R63*|ZNF323_uc003nlc.2_Nonsense_Mutation_p.R222*	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	222					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TTGCTGTCTCGTTTACAAGTT	0.423000												
OR2W1	26692	broad.mit.edu	37	6	29012626	29012626	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:29012626T>C	uc003nlw.2	-	1	327	c.327A>G	c.(325-327)TCA>TCG	p.S109S		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GGCACTCAACTGAGCCCAACC	0.438000												
TFEB	7942	broad.mit.edu	37	6	41655662	41655662	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:41655662C>T	uc003oqs.1	-	6	956	c.654G>A	c.(652-654)CAG>CAA	p.Q218Q	TFEB_uc003oqt.1_Silent_p.Q218Q|TFEB_uc003oqu.1_Silent_p.Q232Q|TFEB_uc003oqv.1_Silent_p.Q218Q|TFEB_uc010jxo.1_Silent_p.Q218Q|TFEB_uc003oqr.1_Silent_p.Q133Q	NM_007162	NP_009093	P19484	TFEB_HUMAN	transcription factor EB	218					embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GCTCTCGCTTCTGGGTCAGGT	0.498000			T	ALPHA	renal (childhood epithelioid)							
RUNX2	860	broad.mit.edu	37	6	45514583	45514583	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:45514583T>C	uc011dvx.1	+	9	1317	c.1107T>C	c.(1105-1107)CCT>CCC	p.P369P	RUNX2_uc011dvy.1_Silent_p.P347P|RUNX2_uc003oxt.2_Silent_p.P355P	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	369	Interaction with MYST3 (By similarity).|Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						AACTGGGCCCTTTTTCAGACC	0.413000												
IMPG1	3617	broad.mit.edu	37	6	76712691	76712691	+	Missense_Mutation	SNP	A	A	C	rs41269327	by1000genomes	TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:76712691A>C	uc003pik.1	-	12	1365	c.1235T>G	c.(1234-1236)CTT>CGT	p.L412R		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	412					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AACAGGAGGAAGTTCTGGACT	0.428000												
DOPEY1	23033	broad.mit.edu	37	6	83806789	83806789	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:83806789C>T	uc003pjs.1	+	3	353	c.93C>T	c.(91-93)TCC>TCT	p.S31S	DOPEY1_uc011dyy.1_Silent_p.S31S|DOPEY1_uc010kbl.1_Silent_p.S31S	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	31					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTGAATACTCCAGTGAATGGG	0.353000												
PRDM13	59336	broad.mit.edu	37	6	100054924	100054924	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:100054924C>G	uc003pqg.1	+	1	275	c.14C>G	c.(13-15)GCC>GGC	p.A5G		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	5	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		CACGGAGCCGCCAGAGCGCCA	0.687000												
C6orf204	387119	broad.mit.edu	37	6	118886759	118886759	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:118886759T>G	uc003pxz.1	-	3	1541	c.953A>C	c.(952-954)TAC>TCC	p.Y318S	C6orf204_uc003pya.1_Missense_Mutation_p.Y321S|C6orf204_uc003pyb.2_Missense_Mutation_p.Y318S|C6orf204_uc011ebj.1_Missense_Mutation_p.Y216S|C6orf204_uc003pyc.2_Missense_Mutation_p.Y321S|C6orf204_uc011ebl.1_Missense_Mutation_p.Y216S	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	318						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		AGCTAAACTGTAAGAATCCTC	0.463000												
RNF217	154214	broad.mit.edu	37	6	125397989	125397989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:125397989C>T	uc003pzs.2	+	6	930	c.592C>T	c.(592-594)CGA>TGA	p.R198*	RNF217_uc003pzr.2_Nonsense_Mutation_p.R255*|RNF217_uc003pzt.2_RNA	NM_152553	NP_689766	Q8TC41	RN217_HUMAN	ring finger protein 217	198					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		GAGATTAGTGCGAGGGTCAGT	0.448000												
EYA4	2070	broad.mit.edu	37	6	133769263	133769263	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:133769263G>T	uc003qec.3	+	5	681	c.223G>T	c.(223-225)GTT>TTT	p.V75F	EYA4_uc011ecq.1_Intron|EYA4_uc011ecr.1_Intron|EYA4_uc003qed.3_Missense_Mutation_p.V75F|EYA4_uc003qee.3_Intron|EYA4_uc011ecs.1_Missense_Mutation_p.V75F|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	75					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		AAACATGACTGTTTTAAACAC	0.433000												
CITED2	10370	broad.mit.edu	37	6	139694714	139694714	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr6:139694714T>A	uc003qip.1	-	2	612	c.368A>T	c.(367-369)TAT>TTT	p.Y123F		NM_006079	NP_006070	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with	123					adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity				0	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		ATGGTTGAAATACTGGTTGTT	0.597000												
GPER	2852	broad.mit.edu	37	7	1132151	1132151	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:1132151G>A	uc010ksd.1	+	2	1176	c.787G>A	c.(787-789)GCG>ACG	p.A263T	C7orf50_uc003sju.2_Intron|C7orf50_uc011jvt.1_Intron|C7orf50_uc011jvu.1_Intron|GPER_uc003sjz.1_Missense_Mutation_p.A263T|GPER_uc003ska.1_Missense_Mutation_p.A263T|GPER_uc003skb.2_Missense_Mutation_p.A263T	NM_001098201	NP_001091671	Q99527	GPER_HUMAN	G protein-coupled receptor 30	263	Helical; Name=6; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CATGATCCTCGCGGTGGTGCT	0.687000												
TRA2A	29896	broad.mit.edu	37	7	23547125	23547125	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:23547125C>T	uc003swi.2	-	5	769	c.555G>A	c.(553-555)CTG>CTA	p.L185L	TRA2A_uc011jzb.1_RNA|TRA2A_uc011jzc.1_Silent_p.L84L|TRA2A_uc011jzd.1_Silent_p.L84L	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	transformer-2 alpha	185	RRM.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1						TTCTACCATCCAGCTCCATTC	0.413000												
GLI3	2737	broad.mit.edu	37	7	42004358	42004358	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:42004358T>G	uc011kbh.1	-	15	4404	c.4313A>C	c.(4312-4314)AAT>ACT	p.N1438T	GLI3_uc011kbg.1_Missense_Mutation_p.N1379T	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1438					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ACCAGAGTAATTCTGCAGATT	0.517000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
ADCY1	107	broad.mit.edu	37	7	45701777	45701777	+	Silent	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:45701777C>A	uc003tne.3	+	8	1587	c.1569C>A	c.(1567-1569)CCC>CCA	p.P523P	ADCY1_uc003tnd.2_Silent_p.P298P	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	523	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCGAGATCCCCTTCTCCAATG	0.512000												
PKD1L1	168507	broad.mit.edu	37	7	47886579	47886579	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:47886579A>G	uc003tny.1	-	32	5051	c.5051T>C	c.(5050-5052)GTA>GCA	p.V1684A		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1684	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CTGGAAATGTACTGTATAGTT	0.423000												
ZPBP	11055	broad.mit.edu	37	7	50070871	50070871	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:50070871C>T	uc003tou.2	-	5	593	c.523G>A	c.(523-525)GCT>ACT	p.A175T	ZPBP_uc011kci.1_Missense_Mutation_p.A101T|ZPBP_uc010kyw.2_Missense_Mutation_p.A174T	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	175					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					TGATATCGAGCTGTGAACTGA	0.313000												
ZNF479	90827	broad.mit.edu	37	7	57187980	57187980	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:57187980T>C	uc010kzo.2	-	5	1413	c.1142A>G	c.(1141-1143)TAC>TGC	p.Y381C		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	381	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCACATGTGTAGGGTTTCTC	0.443000												
TBL2	26608	broad.mit.edu	37	7	72984996	72984996	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:72984996C>T	uc003tyh.2	-	7	1319	c.1185G>A	c.(1183-1185)GCG>GCA	p.A395A	TBL2_uc011kex.1_Silent_p.A359A|TBL2_uc010lbg.2_Silent_p.A300A|TBL2_uc003tyi.2_Silent_p.A230A|TBL2_uc011key.1_Silent_p.A266A|TBL2_uc010lbh.2_Silent_p.A300A	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	395	WD 7.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				ACAGCCGCACCGCCCGGTCCC	0.637000												
SEMA3D	223117	broad.mit.edu	37	7	84727149	84727149	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:84727149A>T	uc003uic.2	-	2	324	c.284T>A	c.(283-285)CTG>CAG	p.L95Q	SEMA3D_uc010led.2_Missense_Mutation_p.L95Q|SEMA3D_uc010lee.1_Missense_Mutation_p.L95Q	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	95	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TAAGTCAACCAGACTGAGTAG	0.358000												
ABCB1	5243	broad.mit.edu	37	7	87179355	87179355	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:87179355G>A	uc003uiz.1	-	14	1784	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*	ABCB1_uc011khc.1_Nonsense_Mutation_p.Q392*	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	456	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTAATATCCTGTCCATCAACA	0.403000												
COL1A2	1278	broad.mit.edu	37	7	94039585	94039585	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:94039585A>T	uc003ung.1	+	20	1538	c.1067A>T	c.(1066-1068)GAG>GTG	p.E356V	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	356					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCCAAAGGAGAGAGCGGTAAC	0.428000										HNSCC(75;0.22)		
CTTNBP2	83992	broad.mit.edu	37	7	117432038	117432038	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr7:117432038G>A	uc003vjf.2	-	4	1304	c.1212C>T	c.(1210-1212)AAC>AAT	p.N404N		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	404	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GAGGGGCAGCGTTACTGGGAA	0.532000												
NRG1	3084	broad.mit.edu	37	8	32599561	32599561	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:32599561A>G	uc003xiv.2	+	7	1185	c.668A>G	c.(667-669)GAG>GGG	p.E223G	NRG1_uc003xip.2_Intron|NRG1_uc010lvn.2_Intron|NRG1_uc003xis.2_Intron|NRG1_uc011lbf.1_Intron|NRG1_uc010lvo.2_Intron|NRG1_uc003xiu.2_Intron|NRG1_uc003xiw.2_Intron|NRG1_uc003xit.2_Missense_Mutation_p.E223G|NRG1_uc010lvr.2_Intron|NRG1_uc010lvs.2_Intron|NRG1_uc010lvp.2_Intron|NRG1_uc010lvq.2_Intron|NRG1_uc003xix.2_Missense_Mutation_p.E113G|NRG1_uc003xiy.2_Intron|NRG1_uc010lvt.2_Intron|NRG1_uc011lbg.1_Missense_Mutation_p.E69G|NRG1_uc011lbh.1_Intron|NRG1_uc003xiz.1_RNA|NRG1_uc003xja.2_Missense_Mutation_p.E26G	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	223	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		AGATGTACTGAGAATGTGCCC	0.413000												
PREX2	80243	broad.mit.edu	37	8	68931899	68931899	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:68931899T>C	uc003xxv.1	+	3	356	c.329T>C	c.(328-330)CTT>CCT	p.L110P	PREX2_uc003xxu.1_Missense_Mutation_p.L110P|PREX2_uc011lez.1_Intron	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	110	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ACCTGCTTTCTTCACTTTGTA	0.353000												
PREX2	80243	broad.mit.edu	37	8	69069612	69069612	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:69069612T>C	uc003xxv.1	+	35	4314	c.4287T>C	c.(4285-4287)TTT>TTC	p.F1429F		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1429					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TGGAAGAATTTCAAGCTCAGA	0.348000												
TPD52	7163	broad.mit.edu	37	8	80954873	80954873	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:80954873T>C	uc003ybr.1	-	5	859	c.537A>G	c.(535-537)GAA>GAG	p.E179E	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_RNA|TPD52_uc003ybs.1_Silent_p.E162E|TPD52_uc003ybt.1_Silent_p.E139E|TPD52_uc003ybq.1_RNA|TPD52_uc003ybu.1_RNA	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	179					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TTTCGACCTTTTCTTCAAATG	0.308000												
CNBD1	168975	broad.mit.edu	37	8	88365898	88365898	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:88365898T>C	uc003ydy.2	+	10	1235	c.1187T>C	c.(1186-1188)CTT>CCT	p.L396P		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	396	cNMP.									ovary(3)	3						ATGGGGAAACTTAAGGAGAAG	0.323000												
KIAA1429	25962	broad.mit.edu	37	8	95539023	95539023	+	Silent	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:95539023G>A	uc003ygo.1	-	8	1462	c.1449C>T	c.(1447-1449)ATC>ATT	p.I483I	KIAA1429_uc003ygp.2_Silent_p.I483I|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	483					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ATAATCCACTGATCACTCCTG	0.413000												
ANGPT1	284	broad.mit.edu	37	8	108334284	108334284	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:108334284T>G	uc003ymn.2	-	4	1116	c.648A>C	c.(646-648)AAA>AAC	p.K216N	ANGPT1_uc011lhv.1_Missense_Mutation_p.K16N|ANGPT1_uc003ymo.2_Missense_Mutation_p.K216N|ANGPT1_uc003ymp.3_Missense_Mutation_p.K16N	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	216	Potential.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			GAAGGTTCTCTTTCTCTTCCT	0.368000												
TRPS1	7227	broad.mit.edu	37	8	116617214	116617214	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:116617214T>G	uc003ynz.2	-	3	1402	c.943A>C	c.(943-945)ACA>CCA	p.T315P	TRPS1_uc011lhy.1_Missense_Mutation_p.T319P|TRPS1_uc003yny.2_Missense_Mutation_p.T328P|TRPS1_uc010mcy.2_Missense_Mutation_p.T315P	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	315					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CCAATGAATGTTCCACCTGAA	0.468000									Langer-Giedion_syndrome			
FAM83H	286077	broad.mit.edu	37	8	144812561	144812561	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:144812561C>T	uc003yzk.2	-	2	261	c.192G>A	c.(190-192)GTG>GTA	p.V64V	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	64					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGTGTCGGCTCACATGTTCCA	0.632000												
SPATC1	375686	broad.mit.edu	37	8	145096245	145096245	+	Silent	SNP	C	C	G	rs17854818		TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:145096245C>G	uc011lkw.1	+	4	1521	c.1419C>G	c.(1417-1419)GTC>GTG	p.V473V	SPATC1_uc011lkx.1_Intron	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	473				V -> A (in Ref. 3; AAH53547).						ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCTTCACTGTCTCCAACATCC	0.642000												
ARHGAP39	80728	broad.mit.edu	37	8	145770695	145770695	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr8:145770695T>A	uc003zdt.1	-	7	3014	c.2459A>T	c.(2458-2460)AAG>ATG	p.K820M	ARHGAP39_uc011llk.1_Missense_Mutation_p.K820M|ARHGAP39_uc003zds.1_Missense_Mutation_p.K820M	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	820	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GGAGTGGAACTTGGGGGTGGG	0.617000												
PTPRD	5789	broad.mit.edu	37	9	8521544	8521544	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr9:8521544G>A	uc003zkk.2	-	19	1405	c.694C>T	c.(694-696)CGC>TGC	p.R232C	PTPRD_uc003zkp.2_Missense_Mutation_p.R232C|PTPRD_uc003zkq.2_Missense_Mutation_p.R232C|PTPRD_uc003zkr.2_Missense_Mutation_p.R226C|PTPRD_uc003zks.2_Missense_Mutation_p.R222C|PTPRD_uc003zkl.2_Missense_Mutation_p.R232C|PTPRD_uc003zkm.2_Missense_Mutation_p.R219C|PTPRD_uc003zkn.2_Missense_Mutation_p.R232C|PTPRD_uc003zko.2_Missense_Mutation_p.R229C	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	232	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGGACACGGCGAACTGGAACA	0.448000										TSP Lung(15;0.13)		
SLC24A2	25769	broad.mit.edu	37	9	19786062	19786062	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr9:19786062A>T	uc003zoa.1	-	1	865	c.803T>A	c.(802-804)CTT>CAT	p.L268H	SLC24A2_uc003zob.1_Missense_Mutation_p.L268H	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	268	Helical; (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TGTTAAGAGAAGCAAGCTTTC	0.393000												
GPR21	2844	broad.mit.edu	37	9	125796920	125796920	+	Silent	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr9:125796920C>T	uc011lzk.1	+	1	75	c.75C>T	c.(73-75)GTC>GTT	p.V25V	RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzh.1_Intron|RABGAP1_uc011lzj.1_Intron|GPR21_uc011lzi.1_RNA	NM_005294	NP_005285	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	25	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1						TGGAAACTGTCAATTTTTGCC	0.388000												
DDX31	64794	broad.mit.edu	37	9	135505739	135505739	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr9:135505739C>T	uc004cbq.1	-	16	2010	c.1858G>A	c.(1858-1860)GCC>ACC	p.A620T	DDX31_uc010mzu.1_Silent_p.P611P	NM_022779	NP_073616	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	620	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		CCAATCCGGGCGGTTCTTCCA	0.478000												
PNPLA7	375775	broad.mit.edu	37	9	140438250	140438250	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr9:140438250G>T	uc004cnf.2	-	4	553	c.216C>A	c.(214-216)AAC>AAA	p.N72K	PNPLA7_uc010ncj.1_Missense_Mutation_p.N97K	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	72					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CCACAAGGGTGTTGGGGAGTG	0.602000												
WDR85	92715	broad.mit.edu	37	9	140468755	140468755	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr9:140468755C>A	uc004cnk.1	-	5	703	c.545G>T	c.(544-546)AGG>ATG	p.R182M	WDR85_uc004cnl.1_Missense_Mutation_p.R6M|WDR85_uc004cnm.1_Translation_Start_Site|WDR85_uc004cnn.1_Intron	NM_138778	NP_620133	Q9BTV6	WDR85_HUMAN	WD repeat domain 85	182					peptidyl-diphthamide biosynthetic process from peptidyl-histidine						0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.00029)|Epithelial(140;0.000509)		CAGCCTGGGCCTCGTCTCATT	0.547000												
MAGEB6	158809	broad.mit.edu	37	X	26212113	26212113	+	Silent	SNP	T	T	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chrX:26212113T>C	uc004dbr.2	+	2	299	c.150T>C	c.(148-150)GGT>GGC	p.G50G	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	50	Ser-rich.									ovary(3)	3						CTTGTCTGGGTGATTGTCGTA	0.542000												
PAGE4	9506	broad.mit.edu	37	X	49597160	49597160	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chrX:49597160G>C	uc004don.1	+	4	278	c.199G>C	c.(199-201)GAT>CAT	p.D67H		NM_007003	NP_008934	O60829	GAGC1_HUMAN	G antigen, family C, 1	67											0	Ovarian(276;0.236)					CCAGGAAATGGATCTGGAAAA	0.343000												
MAGEC1	9947	broad.mit.edu	37	X	140996300	140996300	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chrX:140996300T>A	uc004fbt.2	+	4	3396	c.3110T>A	c.(3109-3111)TTT>TAT	p.F1037Y	MAGEC1_uc010nsl.1_Missense_Mutation_p.F104Y	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1037	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CACTTTGCCTTTGGGGAGCCC	0.542000										HNSCC(15;0.026)		
MAGEC2	51438	broad.mit.edu	37	X	141291458	141291458	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chrX:141291458A>G	uc004fbu.1	-	3	664	c.316T>C	c.(316-318)TCT>CCT	p.S106P		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	106	Ser-rich.					cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CATGAAAAAGAGGAGCAGCAG	0.413000										HNSCC(46;0.14)		
ATP6AP1	537	broad.mit.edu	37	X	153664188	153664188	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chrX:153664188G>A	uc004flf.1	+	10	1425	c.1364G>A	c.(1363-1365)CGC>CAC	p.R455H	ATP6AP1_uc004flg.1_RNA|ATP6AP1_uc004flh.1_Missense_Mutation_p.R415H|GDI1_uc011mzo.1_5'Flank|GDI1_uc004fli.3_5'Flank	NM_001183	NP_001174	Q15904	VAS1_HUMAN	ATPase, H+ transporting, lysosomal accessory	455					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain|vacuolar membrane	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(3)|breast(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ACCATGGATCGCTTTGATGAC	0.562000												
CDK5RAP2	55755	broad.mit.edu	37	9	123205914	123205915	+	In_Frame_Ins	INS	-	-	TGC			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr9:123205914_123205915insTGC	uc004bkf.2	-	23	3312_3313	c.3131_3132insGCA	c.(3130-3132)CAA>CAGCAA	p.1044_1044Q>QQ	CDK5RAP2_uc010mvi.2_Intron|CDK5RAP2_uc004bke.2_In_Frame_Ins_p.329_329Q>QQ|CDK5RAP2_uc004bkg.2_In_Frame_Ins_p.1044_1044Q>QQ|CDK5RAP2_uc011lxw.1_In_Frame_Ins_p.309_309Q>QQ|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_In_Frame_Ins_p.309_309Q>QQ|CDK5RAP2_uc011lya.1_In_Frame_Ins_p.309_309Q>QQ|CDK5RAP2_uc004bkh.1_In_Frame_Ins_p.814_814Q>QQ|CDK5RAP2_uc004bki.2_In_Frame_Ins_p.811_811Q>QQ	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1044	Interaction with MAPRE1.				brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CGTAGCTTCTTTGCTGATCACT	0.356												
USP38	84640	broad.mit.edu	37	4	144135153	144135153	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr4:144135152_144135152GA>G	uc003ijb.3	+	8	2557	c.2023_2023GA>G	c.(2023-2025)gaafs	p.E675fs	USP38_uc003ija.4_Frame_Shift_Del_p.E675fs|USP38_uc003ijc.3_Non-coding_Transcript	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	Homo sapiens ubiquitin specific peptidase 38 (USP38), mRNA.	675					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					ACTTGTGAATGAAAAAACCAT	0.403												
PCDHAC2	56134	broad.mit.edu	37	5	140306936	140306937	+	In_Frame_Ins	INS	-	-	GGG			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr5:140306935_140306936A>AGGG	uc003lih.2	+	0	634_635	c.458_459A>AGGG	c.(457-459)gag>gAGGG	p.E153E	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhs.2_Intron|PCDHAC2_uc003lhu.2_Intron|PCDHAC2_uc003lhw.2_Intron|PCDHAC2_uc003lhx.2_Intron|PCDHAC2_uc003lia.2_Intron|PCDHAC2_uc003lic.2_Intron|PCDHAC2_uc003lif.2_Intron|PCDHAC2_uc003lie.1_Intron|PCDHAC2_uc003lig.1_In_Frame_Ins_p.E153E	NM_018898	NP_061721	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha subfamily C, 1 (PCDHAC1), transcript variant 1, mRNA.	177	Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGACGACGAGGGAAGCAATG	0.594												
CDK5RAP2	55755	broad.mit.edu	37	9	123205915	123205916	+	In_Frame_Ins	INS	-	-	TGC			TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr9:123205914_123205915T>TTGC	uc004bkf.3	-	22	3312_3313	c.3131_3132A>GCAA	c.(3130-3132)caa>cGCAA	p.Q1044R	CDK5RAP2_uc010mvi.3_Intron|CDK5RAP2_uc004bke.3_In_Frame_Ins_p.Q329R|CDK5RAP2_uc004bkg.3_In_Frame_Ins_p.Q1044R|CDK5RAP2_uc011lxw.2_In_Frame_Ins_p.Q309R|CDK5RAP2_uc011lxx.2_Non-coding_Transcript|CDK5RAP2_uc011lxy.2_Non-coding_Transcript|CDK5RAP2_uc011lxz.2_In_Frame_Ins_p.Q309R|CDK5RAP2_uc011lya.2_In_Frame_Ins_p.Q309R|CDK5RAP2_uc004bkh.1_In_Frame_Ins_p.Q814R|CDK5RAP2_uc004bki.3_In_Frame_Ins_p.Q811R	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	Homo sapiens CDK5 regulatory subunit associated protein 2 (CDK5RAP2), transcript variant 1, mRNA.	1044	Interaction with MAPRE1.				G2/M transition of mitotic cell cycle|brain development|centrosome organization|chromosome segregation|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	Golgi apparatus|cytosol|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						CGTAGCTTCTTTGCTGATCACT	0.460												
EPOR	2057	broad.mit.edu	37	19	11488878	11488883	+	In_Frame_Del	DEL	GCAAGA	GCAAGA	-	rs62638744	byFrequency	TCGA-BR-7901-01A-11D-2201-08	TCGA-BR-7901-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	33ad3e8c-f5af-40e4-b6be-bbecd2e9cca1	bf460fea-4897-4f6b-a171-649f443ff56e	g.chr19:11488877_11488882CGCAAGA>C	uc002mrj.2	-	7	1440_1445	c.1305_1310TCTTGCG>G	c.(1303-1311)ctcttgcgt>ctGt	p.LR436del	EPOR_uc010xly.2_In_Frame_Del_p.LR263del|EPOR_uc002mrk.2_In_Frame_Del_p.LR263del|EPOR_uc010xlx.2_Non-coding_Transcript	NM_000121	NP_000112	P19235	EPOR_HUMAN	Homo sapiens erythropoietin receptor (EPOR), transcript variant 1, mRNA.	436						extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	TGTCCATGGACGCAAGAGCTGGGAGC	0.578											OREG0025254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)