Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CLSTN1	22883	broad.mit.edu	37	1	9795564	9795564	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:9795564G>A	uc001aqh.2	-	13	2603	c.1844C>T	c.(1843-1845)ACG>ATG	p.T615M	CLSTN1_uc001aqi.2_Missense_Mutation_p.T605M|CLSTN1_uc010oag.1_Missense_Mutation_p.T596M|CLSTN1_uc001aqf.2_5'Flank	NM_001009566	NP_001009566	O94985	CSTN1_HUMAN	calsyntenin 1 isoform 1	615	Extracellular (Potential).				homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			skin(1)	1	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		AATTCCGGGCGTGGGGAACTG	0.507000												
LRRIQ3	127255	broad.mit.edu	37	1	74648428	74648428	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:74648428T>G	uc001dfy.3	-	3	559	c.367A>C	c.(367-369)ACC>CCC	p.T123P	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	123										ovary(2)	2						GCAATGAGGGTTGGACAGGCA	0.368000												
TNNI3K	51086	broad.mit.edu	37	1	74957799	74957799	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:74957799A>C	uc001dgf.1	+	23	2251	c.2200A>C	c.(2200-2202)AGT>CGT	p.S734R	TNNI3K_uc001dge.1_Missense_Mutation_p.S835R	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	734	Poly-Ser.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						TCCTGCATCAAGTAACAGCAG	0.453000												
ELTD1	64123	broad.mit.edu	37	1	79404899	79404899	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:79404899C>A	uc001diq.3	-	4	526	c.370G>T	c.(370-372)GCA>TCA	p.A124S		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	124	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTAATATTTGCAGCTATACAG	0.244000												
GJA8	2703	broad.mit.edu	37	1	147381267	147381267	+	Silent	SNP	G	G	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:147381267G>T	uc001epu.1	+	2	1248	c.1185G>T	c.(1183-1185)GGG>GGT	p.G395G		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	395	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					CAAAGCAAGGGCTGCCAGCTG	0.577000												
FLG2	388698	broad.mit.edu	37	1	152323733	152323733	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:152323733T>C	uc001ezw.3	-	3	6602	c.6529A>G	c.(6529-6531)AGA>GGA	p.R2177G	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2177	Filaggrin 10.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTAGATCTTTGTCTTCCA	0.512000												
CD1C	911	broad.mit.edu	37	1	158261177	158261177	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:158261177A>T	uc001fru.2	+	2	607	c.315A>T	c.(313-315)CAA>CAT	p.Q105H	CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	105	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					ATGCAAGTCAAGATTACTCGA	0.373000												
CD1E	913	broad.mit.edu	37	1	158324361	158324361	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:158324361T>G	uc001fse.2	+	2	492	c.253T>G	c.(253-255)TTC>GTC	p.F85V	CD1E_uc010pid.1_Missense_Mutation_p.F83V|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.F85V|CD1E_uc001fsk.2_Missense_Mutation_p.F85V|CD1E_uc001fsj.2_Missense_Mutation_p.F85V|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.F85V|CD1E_uc001fry.2_Missense_Mutation_p.F85V|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.F85V|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.F85V|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	85					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					CCATGGAAACTTCAGCAAGCA	0.498000												
NR5A2	2494	broad.mit.edu	37	1	200090021	200090021	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:200090021G>A	uc001gvb.2	+	7	1522	c.1316G>A	c.(1315-1317)CGT>CAT	p.R439H	NR5A2_uc001gvc.2_Missense_Mutation_p.R393H|NR5A2_uc009wzh.2_Missense_Mutation_p.R399H|NR5A2_uc010pph.1_Missense_Mutation_p.R367H	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	439					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					GCAAAACTTCGTTCTCTCCAG	0.438000												
IGFN1	91156	broad.mit.edu	37	1	201185695	201185695	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:201185695G>A	uc001gwc.2	+	5	1661	c.889G>A	c.(889-891)GTG>ATG	p.V297M	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						AGAGTGCTACGTGGTGGAGAG	0.667000												
C4BPA	722	broad.mit.edu	37	1	207317917	207317917	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:207317917T>C	uc001hfo.2	+	12	1843	c.1649T>C	c.(1648-1650)CTC>CCC	p.L550P		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	550					complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						GAACAAGTGCTCACAGGCAAA	0.463000												
HHIPL2	79802	broad.mit.edu	37	1	222721161	222721161	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:222721161G>A	uc001hnh.1	-	1	284	c.226C>T	c.(226-228)CGC>TGC	p.R76C		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	76					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GCGATGCGGCGGTCCTTGTGC	0.532000												
OR2B11	127623	broad.mit.edu	37	1	247614817	247614817	+	Silent	SNP	G	G	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:247614817G>T	uc010pyx.1	-	1	468	c.468C>A	c.(466-468)GGC>GGA	p.G156G		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGTTGCCGAAGCCACTGAGCC	0.612000												
OR14A16	284532	broad.mit.edu	37	1	247978499	247978499	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:247978499T>A	uc001idm.1	-	1	533	c.533A>T	c.(532-534)GAC>GTC	p.D178V		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGGGGAATGTCACAGAAGAA	0.413000												
OR2M5	127059	broad.mit.edu	37	1	248308897	248308897	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:248308897A>G	uc010pze.1	+	1	448	c.448A>G	c.(448-450)ATC>GTC	p.I150V		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CTTCTCCTGGATCCTGGGCTC	0.458000												
OR2T1	26696	broad.mit.edu	37	1	248569626	248569626	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr1:248569626T>G	uc010pzm.1	+	1	331	c.331T>G	c.(331-333)TTC>GTC	p.F111V		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	111	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCCATGTACTTCCTCCTCAG	0.428000												
PFKP	5214	broad.mit.edu	37	10	3147323	3147323	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr10:3147323G>A	uc001igp.2	+	6	673	c.637G>A	c.(637-639)GTT>ATT	p.V213I	PFKP_uc001igq.2_Missense_Mutation_p.V205I|PFKP_uc009xhr.2_Missense_Mutation_p.V175I|PFKP_uc009xhs.1_5'UTR|PFKP_uc009xht.2_5'Flank	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	213					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		GAGGACCTTCGTTCTGGAGGT	0.607000												
ARMC4	55130	broad.mit.edu	37	10	28224130	28224130	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr10:28224130C>A	uc009xky.2	-	16	2402	c.2304G>T	c.(2302-2304)CAG>CAT	p.Q768H	ARMC4_uc010qds.1_Missense_Mutation_p.Q293H|ARMC4_uc010qdt.1_Missense_Mutation_p.Q460H|ARMC4_uc001itz.2_Missense_Mutation_p.Q768H	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	768	ARM 5.						binding			ovary(4)|skin(2)	6						CTTCTTCAGGCTGATCTGTTA	0.443000												
TACC2	10579	broad.mit.edu	37	10	123843296	123843296	+	Silent	SNP	T	T	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr10:123843296T>A	uc001lfv.2	+	4	1641	c.1281T>A	c.(1279-1281)GCT>GCA	p.A427A	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.A427A|TACC2_uc010qtv.1_Silent_p.A427A	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	427						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CATTCCCAGCTGCTCAGATTC	0.557000												
MUC6	4588	broad.mit.edu	37	11	1016757	1016757	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:1016757G>A	uc001lsw.2	-	31	6095	c.6044C>T	c.(6043-6045)TCC>TTC	p.S2015F		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2015	Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGTCACCAAGGAGGTGGAGAA	0.542000												
MUC5B	727897	broad.mit.edu	37	11	1267074	1267074	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:1267074G>A	uc009ycr.1	+	49	10839	c.10713G>A	c.(10711-10713)GGG>GGA	p.G3571G	MUC5B_uc001ltb.2_Silent_p.G2991G	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2988	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACTCCAGGGACGACCTGGA	0.637000												
OR51E1	143503	broad.mit.edu	37	11	4674666	4674666	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:4674666C>T	uc001lzi.3	+	2	1054	c.910C>T	c.(910-912)CGC>TGC	p.R304C		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		GATTCGACAGCGCATCCTTCG	0.478000												
OR2D2	120776	broad.mit.edu	37	11	6913041	6913041	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:6913041T>G	uc010rau.1	-	1	691	c.691A>C	c.(691-693)ACT>CCT	p.T231P		NM_003700	NP_003691	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTCCCCACAGTTGACTTCATC	0.438000												
TPH1	7166	broad.mit.edu	37	11	18062241	18062241	+	Silent	SNP	G	G	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:18062241G>C	uc001mnp.2	-	1	95	c.69C>G	c.(67-69)TCC>TCG	p.S23S	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	23	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	CATTCTTTAAGGAAAAAATGA	0.328000												
ACCSL	390110	broad.mit.edu	37	11	44074584	44074584	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:44074584A>C	uc001mxw.1	+	7	970	c.914A>C	c.(913-915)AAG>ACG	p.K305T	ACCSL_uc009ykr.2_Missense_Mutation_p.K124T	NM_001031854	NP_001027025	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase	305							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5						ACTGTGGACAAGTTAGAGGAA	0.438000												
OR1S1	219959	broad.mit.edu	37	11	57982698	57982698	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:57982698C>T	uc010rkc.1	+	1	482	c.482C>T	c.(481-483)TCA>TTA	p.S161L		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	161	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				ACAGTCATCTCATGGTTCCTC	0.473000												
SCGB1D4	404552	broad.mit.edu	37	11	62064966	62064966	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:62064966G>A	uc001ntd.1	-	2	274	c.220C>T	c.(220-222)CGA>TGA	p.R74*		NM_206998	NP_996881	Q6XE38	SG1D4_HUMAN	secretoglobin family 1D member 4 precursor	74						extracellular region	binding				0						AATGAGAGTCGTTTCTTAAAA	0.448000												
AHNAK	79026	broad.mit.edu	37	11	62298581	62298581	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:62298581A>G	uc001ntl.2	-	5	3608	c.3308T>C	c.(3307-3309)ATC>ACC	p.I1103T	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1103					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				GGGACCTCTGATGTCCACATC	0.458000												
FAM89B	23625	broad.mit.edu	37	11	65341036	65341036	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:65341036C>T	uc001oem.2	+	2	776	c.455C>T	c.(454-456)CCG>CTG	p.P152L	FAM89B_uc001oen.2_3'UTR|FAM89B_uc001oel.2_Missense_Mutation_p.P165L|EHBP1L1_uc001oeo.3_5'Flank	NM_152832	NP_690045	Q8N5H3	FA89B_HUMAN	family with sequence similarity 89, member B	152											0						CCTCCTGACCCGCCACCCCTT	0.662000												
ANKRD42	338699	broad.mit.edu	37	11	82938901	82938901	+	Silent	SNP	T	T	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:82938901T>A	uc001ozz.1	+	7	1238	c.816T>A	c.(814-816)ACT>ACA	p.T272T	ANKRD42_uc010rsv.1_Silent_p.T300T|ANKRD42_uc001paa.2_Silent_p.T300T|ANKRD42_uc001pab.1_Silent_p.T299T	NM_182603	NP_872409	Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	272	ANK 8.									skin(1)	1						ATGGATCAACTCCTATGCATA	0.378000												
SLC35F2	54733	broad.mit.edu	37	11	107663456	107663456	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:107663456G>A	uc001pjq.2	-	8	1431	c.1010C>T	c.(1009-1011)ACT>ATT	p.T337I	SLC35F2_uc010rvu.1_Missense_Mutation_p.T189I	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	337					transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		GGCCGTGCGAGTAGGGGTGGA	0.557000												
EXPH5	23086	broad.mit.edu	37	11	108383530	108383530	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:108383530A>T	uc001pkk.2	-	6	2815	c.2704T>A	c.(2704-2706)TCT>ACT	p.S902T	EXPH5_uc010rvy.1_Missense_Mutation_p.S714T|EXPH5_uc010rvz.1_Missense_Mutation_p.S746T|EXPH5_uc010rwa.1_Missense_Mutation_p.S826T	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	902					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		ACTGTAGTAGATGGAACCACA	0.443000												
ARHGAP20	57569	broad.mit.edu	37	11	110451100	110451100	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:110451100A>G	uc001pkz.1	-	16	2855	c.2570T>C	c.(2569-2571)CTG>CCG	p.L857P	ARHGAP20_uc001pky.1_Missense_Mutation_p.L834P|ARHGAP20_uc009yyb.1_Missense_Mutation_p.L821P|ARHGAP20_uc001pla.1_Missense_Mutation_p.L821P|ARHGAP20_uc001plb.2_Missense_Mutation_p.L400P	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	857					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GAGATAGGTCAGCTTGCGGTT	0.493000												
BCO2	83875	broad.mit.edu	37	11	112046403	112046403	+	Missense_Mutation	SNP	C	C	T	rs149163526		TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:112046403C>T	uc001pnf.2	+	1	196	c.79C>T	c.(79-81)CGG>TGG	p.R27W	BCO2_uc001pne.1_5'UTR|BCO2_uc001png.2_Missense_Mutation_p.R27W|BCO2_uc001pnh.2_5'Flank|BCO2_uc010rwt.1_5'Flank|BCO2_uc009yyn.2_5'Flank|BCO2_uc001pni.2_5'Flank	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	27					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GATGGTGCACCGGCTCCCAGG	0.483000												
IL10RA	3587	broad.mit.edu	37	11	117864106	117864106	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:117864106A>C	uc001prv.2	+	4	595	c.518A>C	c.(517-519)AAG>ACG	p.K173T	IL10RA_uc010rxl.1_Missense_Mutation_p.K153T|IL10RA_uc010rxm.1_Missense_Mutation_p.K153T|IL10RA_uc010rxn.1_Missense_Mutation_p.K24T|IL10RA_uc001prw.2_Missense_Mutation_p.K24T	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	173	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		GCCATTCGCAAGGTGCCGGGA	0.572000												
SC5DL	6309	broad.mit.edu	37	11	121174091	121174091	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:121174091C>T	uc001pxu.2	+	2	155	c.7C>T	c.(7-9)CTT>TTT	p.L3F	SC5DL_uc001pxs.1_Missense_Mutation_p.L3F|SC5DL_uc001pxt.2_Missense_Mutation_p.L3F|SC5DL_uc001pxv.2_Missense_Mutation_p.L3F	NM_006918	NP_008849	O75845	SC5D_HUMAN	sterol-C5-desaturase	3					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	C-5 sterol desaturase activity|iron ion binding|lathosterol oxidase activity			ovary(1)	1		Breast(109;0.00328)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)	OV - Ovarian serous cystadenocarcinoma(1;0.0334)	BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		AGTGATGGATCTTGTACTCCG	0.373000												
TMEM225	338661	broad.mit.edu	37	11	123754862	123754862	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr11:123754862T>C	uc001pzi.2	-	3	591	c.383A>G	c.(382-384)CAA>CGA	p.Q128R		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	128						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						GTGCATGGATTGACCTTGCTT	0.373000												
PRB2	653247	broad.mit.edu	37	12	11546745	11546745	+	Silent	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:11546745A>G	uc010shk.1	-	3	302	c.267T>C	c.(265-267)CCT>CCC	p.P89P		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGGACCTTGAGGTTTGTTGC	0.617000												
EPS8	2059	broad.mit.edu	37	12	15811059	15811059	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:15811059G>C	uc009zif.2	-	12	1149	c.1055C>G	c.(1054-1056)CCT>CGT	p.P352R	EPS8_uc001rdb.2_Missense_Mutation_p.P352R|EPS8_uc009zig.2_Missense_Mutation_p.P92R|EPS8_uc010shv.1_Missense_Mutation_p.P92R	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	352					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		TGCAGCACTAGGATTCTGAAT	0.343000												
SLCO1C1	53919	broad.mit.edu	37	12	20876091	20876091	+	Silent	SNP	T	T	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:20876091T>A	uc001rej.3	+	10	1444	c.1089T>A	c.(1087-1089)ACT>ACA	p.T363T	SLCO1C1_uc010sii.1_Silent_p.T363T|SLCO1C1_uc010sij.1_Silent_p.T314T|SLCO1C1_uc009zip.2_Silent_p.T197T|SLCO1C1_uc001rei.2_Silent_p.T363T|SLCO1C1_uc010sik.1_Silent_p.T245T	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	363	Helical; Name=7; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					GTACAAGCACTGTTCAGTTCA	0.378000												
BCAT1	586	broad.mit.edu	37	12	25047227	25047227	+	Silent	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:25047227A>C	uc001rgd.3	-	3	703	c.261T>G	c.(259-261)GCT>GCG	p.A87A	BCAT1_uc001rgc.2_Silent_p.A86A|BCAT1_uc010six.1_Silent_p.A99A|BCAT1_uc010siy.1_Silent_p.A87A|BCAT1_uc001rge.3_Silent_p.A63A	NM_005504	NP_005495	P54687	BCAT1_HUMAN	branched chain aminotransferase 1, cytosolic	87					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			lung(1)|breast(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	CATAGTGCAAAGCTGATGAGC	0.468000												
ADAMTS20	80070	broad.mit.edu	37	12	43821195	43821195	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:43821195G>A	uc010skx.1	-	27	4023	c.4023C>T	c.(4021-4023)TAC>TAT	p.Y1341Y	ADAMTS20_uc001rno.1_Silent_p.Y459Y	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1341	TSP type-1 9.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGCATCGCAGTAACTAGCAC	0.468000												
KRT73	319101	broad.mit.edu	37	12	53010156	53010156	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:53010156G>A	uc001sas.2	-	2	491	c.456C>T	c.(454-456)TTC>TTT	p.F152F		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	152	Coil 1A.|Rod.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTGCTCCAGGAACCGCACCT	0.522000												
DGKA	1606	broad.mit.edu	37	12	56335305	56335305	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:56335305A>C	uc001sij.2	+	15	1451	c.1187A>C	c.(1186-1188)AAG>ACG	p.K396T	DGKA_uc001sih.1_Missense_Mutation_p.K284T|DGKA_uc001sii.1_Missense_Mutation_p.K254T|DGKA_uc009zod.1_Missense_Mutation_p.K315T|DGKA_uc001sik.2_Missense_Mutation_p.K396T|DGKA_uc001sil.2_Missense_Mutation_p.K396T|DGKA_uc001sim.2_Missense_Mutation_p.K396T|DGKA_uc001sin.2_Missense_Mutation_p.K396T|DGKA_uc009zof.2_Missense_Mutation_p.K42T|DGKA_uc001sio.2_Missense_Mutation_p.K138T	NM_001345	NP_001336	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	396	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			ovary(3)|pancreas(1)	4					Vitamin E(DB00163)	GTGCTCTGGAAGTTCCAGTAT	0.498000												
CCDC41	51134	broad.mit.edu	37	12	94763808	94763808	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:94763808T>C	uc001tdd.2	-	9	1524	c.938A>G	c.(937-939)AAA>AGA	p.K313R	CCDC41_uc001tde.2_Missense_Mutation_p.K313R|CCDC41_uc009zsw.1_RNA|CCDC41_uc001tdf.2_Missense_Mutation_p.K313R	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	305	Potential.										0						TTTAAGTTCTTTTACCTGTTG	0.333000												
CCDC38	120935	broad.mit.edu	37	12	96273421	96273421	+	Splice_Site	SNP	C	C	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:96273421C>G	uc001tek.1	-	12	1376	c.1142_splice	c.e12+1	p.T381_splice		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38											skin(1)	1						TAATGACTTACGTTTTATCCT	0.368000												
MYO1H	283446	broad.mit.edu	37	12	109844646	109844646	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:109844646T>G	uc010sxn.1	+	8	968	c.968T>G	c.(967-969)ATT>AGT	p.I323S		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	70						myosin complex	motor activity				0						CACAGAAAAATTGAAGCCAAA	0.498000												
KSR2	283455	broad.mit.edu	37	12	117909125	117909125	+	Silent	SNP	G	G	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:117909125G>T	uc001two.2	-	18	2551	c.2496C>A	c.(2494-2496)GGC>GGA	p.G832G		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	861	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACCAGATTGTGCTGTTGGCAG	0.522000												
SBNO1	55206	broad.mit.edu	37	12	123794051	123794051	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr12:123794051G>A	uc010tap.1	-	26	3522	c.3522C>T	c.(3520-3522)CAC>CAT	p.H1174H	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Silent_p.H1173H|SBNO1_uc010taq.1_Silent_p.H125H|SBNO1_uc001ues.1_Silent_p.H125H	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1174							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ATAATTCTACGTGGCCAGAGG	0.348000												
BRCA2	675	broad.mit.edu	37	13	32972435	32972435	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr13:32972435A>C	uc001uub.1	+	27	10012	c.9785A>C	c.(9784-9786)CAA>CCA	p.Q3262P		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3262					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ATTGATGACCAAAAGAACTGC	0.438000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)		
BRCA2	675	broad.mit.edu	37	13	32972587	32972587	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr13:32972587A>C	uc001uub.1	+	27	10164	c.9937A>C	c.(9937-9939)AAG>CAG	p.K3313Q		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3313					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AACACCCATAAAGAAAAAAGA	0.388000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)		
KIAA0564	23078	broad.mit.edu	37	13	42465633	42465633	+	Silent	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr13:42465633A>G	uc001uyj.2	-	5	644	c.574T>C	c.(574-576)TTG>CTG	p.L192L	KIAA0564_uc001uyk.2_Silent_p.L192L	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	192						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		TTTTCCAGCAAGTTGTTCAAA	0.448000												
PCDH20	64881	broad.mit.edu	37	13	61985896	61985896	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr13:61985896A>G	uc001vid.3	-	2	2700	c.2336T>C	c.(2335-2337)GTC>GCC	p.V779A	PCDH20_uc010thj.1_Missense_Mutation_p.V779A	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	752	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GTAAGCTATGACAGCATTCAT	0.473000												
SLITRK5	26050	broad.mit.edu	37	13	88328652	88328652	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr13:88328652C>A	uc001vln.2	+	2	1228	c.1009C>A	c.(1009-1011)CCC>ACC	p.P337T	SLITRK5_uc010tic.1_Missense_Mutation_p.P96T	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	337	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GACTCGCCAACCCAACAAGCC	0.587000												
MIA2	117153	broad.mit.edu	37	14	39709847	39709847	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr14:39709847C>T	uc001wux.2	+	3	526	c.332C>T	c.(331-333)ACG>ATG	p.T111M	MIA2_uc010amy.1_Missense_Mutation_p.T42M	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	111	SH3.					extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		CAGATGTCAACGAAAGTGAGT	0.348000												
FAM179B	23116	broad.mit.edu	37	14	45433301	45433301	+	Silent	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr14:45433301A>G	uc001wvv.2	+	1	1886	c.1677A>G	c.(1675-1677)CAA>CAG	p.Q559Q	FAM179B_uc001wvw.2_Silent_p.Q559Q|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Silent_p.Q559Q|FAM179B_uc001wvu.2_Silent_p.Q559Q	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	559							binding			skin(2)|upper_aerodigestive_tract(1)	3						TTGAACTGCAAGATAATGGAG	0.453000												
TBPL2	387332	broad.mit.edu	37	14	55881108	55881108	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr14:55881108T>A	uc001xby.2	-	7	1117	c.1117A>T	c.(1117-1119)AAA>TAA	p.K373*	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbx.1_5'Flank	NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	373					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						CAGGCTTTTTTAAAACCTTTT	0.328000												
GPX2	2877	broad.mit.edu	37	14	65406340	65406340	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr14:65406340G>A	uc010tsn.1	-	3	526	c.439C>T	c.(439-441)CGC>TGC	p.R147C	CHURC1_uc010tsj.1_Intron|CHURC1_uc010tsk.1_Intron|FNTB_uc010tsl.1_Intron|FNTB_uc010tsm.1_Intron|GPX2_uc001xhy.1_RNA	NM_002083	NP_002074	P18283	GPX2_HUMAN	glutathione peroxidase 2	147					response to oxidative stress	cytoplasm	electron carrier activity|glutathione peroxidase activity			ovary(1)	1				all cancers(60;0.00117)|OV - Ovarian serous cystadenocarcinoma(108;0.00557)|BRCA - Breast invasive adenocarcinoma(234;0.00971)	Glutathione(DB00143)	ACATCTGAGCGGCGCACAGGG	0.562000												
KIAA1409	57578	broad.mit.edu	37	14	94060075	94060075	+	Missense_Mutation	SNP	G	G	A	rs139389360		TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr14:94060075G>A	uc001ybv.1	+	20	2634	c.2551G>A	c.(2551-2553)GTC>ATC	p.V851I	KIAA1409_uc001ybs.1_Missense_Mutation_p.V851I	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1028						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTCCCTGGCAGTCCCTCTTCT	0.483000												
C15orf2	23742	broad.mit.edu	37	15	24921670	24921670	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr15:24921670A>T	uc001ywo.2	+	1	1130	c.656A>T	c.(655-657)AAC>ATC	p.N219I		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	219					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TTCTCAGAAAACAGCATGAGT	0.617000												
CTDSPL2	51496	broad.mit.edu	37	15	44816331	44816331	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr15:44816331A>G	uc001ztr.2	+	13	1776	c.1360A>G	c.(1360-1362)AGA>GGA	p.R454G	CTDSPL2_uc001zts.2_Missense_Mutation_p.R454G|CTDSPL2_uc001ztt.2_Missense_Mutation_p.R454G|CTDSPL2_uc010bdv.2_Missense_Mutation_p.R382G	NM_016396	NP_057480	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	454							phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		ACCACACATCAGAGACAGATT	0.388000												
CYP11A1	1583	broad.mit.edu	37	15	74659825	74659825	+	Silent	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr15:74659825A>G	uc002axt.2	-	1	257	c.102T>C	c.(100-102)ACT>ACC	p.T34T	CYP11A1_uc002axs.2_5'Flank|CYP11A1_uc010bjm.1_5'Flank|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Silent_p.T34T|CYP11A1_uc010ulj.1_5'UTR|CYP11A1_uc010bjq.2_Silent_p.T34T	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	34					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CTCCCTCGCCAGTGGGCACCC	0.632000												
MEX3B	84206	broad.mit.edu	37	15	82335547	82335547	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr15:82335547G>A	uc002bgq.1	-	2	1979	c.1664C>T	c.(1663-1665)CCG>CTG	p.P555L		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	555	RING-type.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						GTGGCAGACCGGGCACTCGGG	0.637000												
RHCG	51458	broad.mit.edu	37	15	90023598	90023598	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr15:90023598G>A	uc002bnz.2	-	4	588	c.564C>T	c.(562-564)GGC>GGT	p.G188G	RHCG_uc002bny.2_5'Flank|RHCG_uc002boa.2_RNA|RHCG_uc010bnq.1_Silent_p.G72G	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	188	Helical; (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					CAAAGTAGGCGCCAAATGTGT	0.577000												
IGF1R	3480	broad.mit.edu	37	15	99434708	99434708	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr15:99434708G>A	uc002bul.2	+	3	845	c.795G>A	c.(793-795)CCG>CCA	p.P265P	IGF1R_uc010urq.1_Silent_p.P265P|IGF1R_uc010bon.2_Silent_p.P265P	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	265					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CTGCCTGCCCGCCCAACACCT	0.642000												
ACSM2B	348158	broad.mit.edu	37	16	20576139	20576139	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr16:20576139A>C	uc002dhj.3	-	3	239	c.29T>G	c.(28-30)CTT>CGT	p.L10R	ACSM2B_uc002dhk.3_Missense_Mutation_p.L10R|ACSM2B_uc010bwf.1_Missense_Mutation_p.L10R	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	10					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CAGGGTGCAAAGTCCCTGAAC	0.507000												
PRSS36	146547	broad.mit.edu	37	16	31157137	31157137	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr16:31157137G>A	uc002ebd.2	-	6	752	c.693C>T	c.(691-693)TAC>TAT	p.Y231Y	PRSS36_uc010vff.1_Silent_p.Y6Y|PRSS36_uc010vfg.1_Silent_p.Y231Y|PRSS36_uc010vfh.1_Silent_p.Y231Y	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	231	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						GGCCCTCTGGGTAGCCAGCAC	0.602000												
IRX5	10265	broad.mit.edu	37	16	54967389	54967389	+	Silent	SNP	C	C	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr16:54967389C>G	uc002ehv.2	+	3	1056	c.1056C>G	c.(1054-1056)GGC>GGG	p.G352G	IRX5_uc002ehw.2_Silent_p.G286G	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	352	Poly-Gly.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						ACGGGGGCGGCGGGAACGAGG	0.731000												
CNOT1	23019	broad.mit.edu	37	16	58612764	58612764	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr16:58612764A>C	uc002env.2	-	13	1716	c.1423T>G	c.(1423-1425)TTC>GTC	p.F475V	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.F475V|CNOT1_uc002enx.2_Missense_Mutation_p.F475V|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	475					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TTGATAGGGAAGCTGAAGAGC	0.458000												
MTSS1L	92154	broad.mit.edu	37	16	70697994	70697994	+	Silent	SNP	C	C	T	rs144949231		TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr16:70697994C>T	uc002ezj.2	-	15	2090	c.1830G>A	c.(1828-1830)GCG>GCA	p.A610A		NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	610					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						CCTCACTGCCCGCCCGTGTGG	0.692000												
BCMO1	53630	broad.mit.edu	37	16	81314536	81314536	+	Silent	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr16:81314536A>G	uc002fgn.1	+	8	1394	c.1176A>G	c.(1174-1176)CAA>CAG	p.Q392Q	BCMO1_uc010vnp.1_Silent_p.Q323Q	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	392					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						AAGATGGCCAAGTCTACTGCC	0.443000												
ZC3H18	124245	broad.mit.edu	37	16	88691082	88691082	+	Silent	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr16:88691082C>T	uc002fky.2	+	12	2171	c.1971C>T	c.(1969-1971)CCC>CCT	p.P657P	ZC3H18_uc010voz.1_Silent_p.P681P|ZC3H18_uc010chw.2_RNA|ZC3H18_uc002fkz.2_5'Flank	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	657	Ser-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		CTCCTGTCCCCGAGCCCACCA	0.692000												
PITPNM3	83394	broad.mit.edu	37	17	6374626	6374626	+	Silent	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:6374626C>A	uc002gdd.3	-	12	1630	c.1479G>T	c.(1477-1479)CGG>CGT	p.R493R	PITPNM3_uc010cln.2_Silent_p.R457R|PITPNM3_uc010clm.2_5'UTR|PITPNM3_uc002gdc.3_Silent_p.R84R	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	493	DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GCGGGCTGTCCCGGGAGCTGC	0.662000												
TP53	7157	broad.mit.edu	37	17	7577156	7577156	+	Splice_Site	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:7577156C>T	uc002gim.2	-	8	977	c.783_splice	c.e8-1	p.S261_splice	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Splice_Site_p.S261_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.S129_splice|TP53_uc010cng.1_Splice_Site_p.S129_splice|TP53_uc002gii.1_Splice_Site_p.S129_splice|TP53_uc010cnh.1_Splice_Site_p.S261_splice|TP53_uc010cni.1_Splice_Site_p.S261_splice|TP53_uc002gij.2_Splice_Site_p.S261_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(18)|p.0?(7)|p.E258fs*71(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TAGATTACCACTACTCAGGAT	0.512000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
JUP	3728	broad.mit.edu	37	17	39923791	39923791	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:39923791A>G	uc002hxq.2	-	5	1026	c.749T>C	c.(748-750)CTG>CCG	p.L250P	JUP_uc010wfs.1_Missense_Mutation_p.L250P|JUP_uc002hxr.2_Missense_Mutation_p.L250P|JUP_uc002hxs.2_Missense_Mutation_p.L250P	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	250	ARM 2.				adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		CAGGTTGTGCAGCGTGGTGAT	0.627000												
WNK4	65266	broad.mit.edu	37	17	40945635	40945635	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:40945635C>T	uc002ibj.2	+	12	2204	c.2183C>T	c.(2182-2184)TCG>TTG	p.S728L	WNK4_uc010wgx.1_Missense_Mutation_p.S392L|WNK4_uc002ibk.1_Missense_Mutation_p.S500L|WNK4_uc010wgy.1_Missense_Mutation_p.S72L	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	728					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		ATTCTGCCTTCGGAGCGAGAT	0.527000												
XYLT2	64132	broad.mit.edu	37	17	48433527	48433527	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:48433527C>T	uc002iqo.2	+	7	1496	c.1387C>T	c.(1387-1389)CGC>TGC	p.R463C	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	463	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					CAACTGGAACCGCAAGCTGGG	0.597000												
KIF2B	84643	broad.mit.edu	37	17	51901040	51901040	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:51901040G>A	uc002iua.2	+	1	802	c.646G>A	c.(646-648)GTC>ATC	p.V216I	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	216	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TCGCATCTGCGTCTGCGTGAG	0.547000												
SCN4A	6329	broad.mit.edu	37	17	62026057	62026057	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:62026057G>C	uc002jds.1	-	16	3135	c.3058C>G	c.(3058-3060)CTG>GTG	p.L1020V		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1020					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	GCCCTGCGCAGAGTCCACCAC	0.617000												
MEX3C	51320	broad.mit.edu	37	18	48703728	48703728	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr18:48703728C>T	uc002lfc.3	-	2	973	c.973G>A	c.(973-975)GGT>AGT	p.G325S		NM_016626	NP_057710	Q5U5Q3	MEX3C_HUMAN	ring finger and KH domain containing 2	325						cytoplasm|nucleus	RNA binding|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		Colorectal(6;0.003)|all_epithelial(6;0.0473)		Colorectal(16;0.0175)|READ - Rectum adenocarcinoma(32;0.15)		GTGGTTTGACCGGGCAGATTA	0.498000												
CD320	51293	broad.mit.edu	37	19	8369960	8369960	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:8369960C>G	uc002mjj.1	-	2	288	c.223G>C	c.(223-225)GAC>CAC	p.D75H	CD320_uc002mjk.1_RNA|CD320_uc002mjl.1_Intron	NM_016579	NP_057663	Q9NPF0	CD320_HUMAN	8D6 antigen isoform 1 precursor	75	Extracellular (Potential).|LDL-receptor class A 1.				regulation of cell growth	endoplasmic reticulum|integral to membrane	growth factor activity				0						AAGTCCCTGTCGCAGCGCCAG	0.662000												
KRI1	65095	broad.mit.edu	37	19	10665849	10665849	+	Silent	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:10665849C>T	uc002moy.1	-	18	1722	c.1713G>A	c.(1711-1713)GAG>GAA	p.E571E	KRI1_uc002mow.1_Silent_p.E190E|KRI1_uc002mox.1_Silent_p.E567E	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	571										ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CCCGCAGCTCCTCCTGCTCTG	0.527000												
ZNF682	91120	broad.mit.edu	37	19	20117991	20117991	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:20117991C>T	uc002noq.2	-	4	443	c.320G>A	c.(319-321)GGA>GAA	p.G107E	ZNF682_uc002noo.2_Missense_Mutation_p.G75E|ZNF682_uc002nop.2_Missense_Mutation_p.G75E|ZNF682_uc010eck.2_Missense_Mutation_p.G31E	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						ATCCTCAAGTCCACAGCTTCC	0.373000												
ZNF345	25850	broad.mit.edu	37	19	37368345	37368345	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:37368345A>G	uc002oex.2	+	3	991	c.613A>G	c.(613-615)ATA>GTA	p.I205V	ZNF345_uc002oey.3_Missense_Mutation_p.I205V|ZNF345_uc002oez.2_Intron	NM_003419	NP_003410	Q14585	ZN345_HUMAN	zinc finger protein 345	205	C2H2-type 6.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTATGAATGTATAGATTGTGG	0.423000												
C19orf33	64073	broad.mit.edu	37	19	38795285	38795285	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:38795285G>A	uc002ohu.1	+	3	258	c.160G>A	c.(160-162)GAC>AAC	p.D54N	YIF1B_uc002ohw.2_3'UTR|YIF1B_uc002ohx.2_3'UTR|YIF1B_uc010xtx.1_3'UTR|YIF1B_uc010xty.1_3'UTR|YIF1B_uc002oia.2_3'UTR|YIF1B_uc002ohy.2_3'UTR|YIF1B_uc002ohz.2_3'UTR|C19orf33_uc002ohv.1_Silent_p.P73P	NM_033520	NP_277055	Q9GZP8	IMUP_HUMAN	HAI-2 related small protein	54						nucleus					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CAGCTCTTCCGACTCCAGCAG	0.662000												
RYR1	6261	broad.mit.edu	37	19	38991278	38991278	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:38991278G>A	uc002oit.2	+	46	7486	c.7356G>A	c.(7354-7356)CGG>CGA	p.R2452R	RYR1_uc002oiu.2_Silent_p.R2452R|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2452	Cytoplasmic.|6 X approximate repeats.		R -> W (in MHS1).		muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGGCCCTGCGGATCCGCGCCA	0.642000												
PPP1R13L	10848	broad.mit.edu	37	19	45899878	45899878	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:45899878C>T	uc002pbn.2	-	4	714	c.637G>A	c.(637-639)GCG>ACG	p.A213T	PPP1R13L_uc002pbo.2_Missense_Mutation_p.A213T|PPP1R13L_uc002pbp.2_Missense_Mutation_p.A213T	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	213	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GACGCTGGCGCGTCGTAGGCT	0.786000												
CD33	945	broad.mit.edu	37	19	51728508	51728508	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:51728508A>T	uc002pwa.2	+	2	112	c.72A>T	c.(70-72)CAA>CAT	p.Q24H	CD33_uc010eos.1_Missense_Mutation_p.Q24H|CD33_uc010eot.1_Intron|CD33_uc010eou.1_5'Flank	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	24	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	TCTGGCTGCAAGTGCAGGAGT	0.592000												
ZNF528	84436	broad.mit.edu	37	19	52918410	52918410	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:52918410A>T	uc002pzh.2	+	7	731	c.305A>T	c.(304-306)AAC>ATC	p.N102I	ZNF528_uc002pzi.2_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		AATGCAGGAAACAAGCCTTGT	0.373000												
PRKCG	5582	broad.mit.edu	37	19	54407962	54407962	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:54407962C>T	uc002qcq.1	+	16	2012	c.1730C>T	c.(1729-1731)TCG>TTG	p.S577L	PRKCG_uc010yeg.1_Missense_Mutation_p.S577L|PRKCG_uc010yeh.1_Intron	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	577	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TACCCCAAGTCGCTTTCCCGG	0.562000												
LILRB5	10990	broad.mit.edu	37	19	54755967	54755967	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:54755967C>T	uc002qex.2	-	12	1687	c.1576G>A	c.(1576-1578)GCT>ACT	p.A526T	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.A518T|LILRB5_uc002qey.2_Missense_Mutation_p.A527T|LILRB5_uc002qez.2_Missense_Mutation_p.A427T|LILRB5_uc002qfa.1_3'UTR	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	526	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TTCACGGCAGCATCTGCTGGG	0.637000												
ZFP28	140612	broad.mit.edu	37	19	57060356	57060356	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:57060356T>G	uc002qnj.2	+	5	624	c.553T>G	c.(553-555)TTA>GTA	p.L185V	ZFP28_uc002qni.2_Missense_Mutation_p.L185V|uc002qnk.1_Intron	NM_020828	NP_065879	Q8NHY6	ZFP28_HUMAN	zinc finger protein 28	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GATCAAGGAGTTACCTCTCAA	0.398000												
ZNF211	10520	broad.mit.edu	37	19	58152621	58152621	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:58152621T>A	uc002qpq.2	+	3	947	c.767T>A	c.(766-768)CTT>CAT	p.L256H	ZNF211_uc010yhb.1_Missense_Mutation_p.L260H|ZNF211_uc002qpp.2_Missense_Mutation_p.L269H|ZNF211_uc002qpr.2_Missense_Mutation_p.L320H|ZNF211_uc002qps.2_Missense_Mutation_p.L321H|ZNF211_uc002qpt.2_Missense_Mutation_p.L268H|ZNF211_uc010yhc.1_Missense_Mutation_p.L268H|ZNF211_uc010yhd.1_Missense_Mutation_p.L195H|ZNF211_uc010yhe.1_Missense_Mutation_p.L247H	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	256						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGAGAAGGACTTTTTGAGTGC	0.428000												
ZSCAN4	201516	broad.mit.edu	37	19	58189377	58189377	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr19:58189377A>C	uc002qpu.2	+	4	1189	c.492A>C	c.(490-492)CAA>CAC	p.Q164H		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	164					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGAATGCCCAAACCACAAGAG	0.468000												
TPO	7173	broad.mit.edu	37	2	1497732	1497732	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:1497732T>C	uc002qww.2	+	11	2018	c.1927T>C	c.(1927-1929)TTC>CTC	p.F643L	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.F586L|TPO_uc002qwr.2_Missense_Mutation_p.F643L|TPO_uc002qwx.2_Missense_Mutation_p.F586L|TPO_uc010yio.1_Missense_Mutation_p.F470L|TPO_uc010yip.1_Missense_Mutation_p.F643L|TPO_uc002qwy.1_5'UTR|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	643	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AGCTGAAAACTTCCTCCCCAG	0.582000												
XDH	7498	broad.mit.edu	37	2	31572645	31572645	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:31572645T>G	uc002rnv.1	-	26	2955	c.2876A>C	c.(2875-2877)AAG>ACG	p.K959T		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	959					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	ACCCTCAAGCTTCTGGTTGAA	0.502000												
BIRC6	57448	broad.mit.edu	37	2	32602775	32602775	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:32602775G>A	uc010ezu.2	+	2	579	c.445G>A	c.(445-447)GCT>ACT	p.A149T		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	149					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GTTAGACACTGCTCTGCAAAC	0.388000												
BIRC6	57448	broad.mit.edu	37	2	32724719	32724719	+	Silent	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:32724719C>T	uc010ezu.2	+	46	8708	c.8574C>T	c.(8572-8574)GCC>GCT	p.A2858A		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2858					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTATTTCTGCCGTGATAGAAT	0.443000												
FSHR	2492	broad.mit.edu	37	2	49381499	49381499	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:49381499G>T	uc002rww.2	-	1	132	c.58C>A	c.(58-60)CAT>AAT	p.H20N	FSHR_uc002rwx.2_Missense_Mutation_p.H20N|FSHR_uc010fbn.2_Missense_Mutation_p.H20N|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	20	LRRNT.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CAGATCCGATGATGACATCCT	0.498000									Gonadal_Dysgenesis_46_XX			
PROKR1	10887	broad.mit.edu	37	2	68882556	68882556	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:68882556A>G	uc010yqj.1	+	2	1030	c.1030A>G	c.(1030-1032)ACC>GCC	p.T344A	PROKR1_uc002ses.2_RNA	NM_138964	NP_620414	Q8TCW9	PKR1_HUMAN	G protein-coupled receptor 73	344	Cytoplasmic (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(1)	1						GTGCTTCGTGACCGTCAAGAA	0.507000												
ST6GAL2	84620	broad.mit.edu	37	2	107459867	107459867	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:107459867G>A	uc002tdq.2	-	2	686	c.567C>T	c.(565-567)GGC>GGT	p.G189G	ST6GAL2_uc002tdr.2_Silent_p.G189G|ST6GAL2_uc002tds.3_Silent_p.G189G	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	189	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CGCCGTCGTCGCCCTCCTCCA	0.642000												
LRP1B	53353	broad.mit.edu	37	2	141812802	141812802	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:141812802G>C	uc002tvj.1	-	10	2407	c.1435C>G	c.(1435-1437)CCA>GCA	p.P479A	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	479	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTCCATATGGATCGACTTCA	0.433000										TSP Lung(27;0.18)		
SCN3A	6328	broad.mit.edu	37	2	165986737	165986737	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:165986737C>A	uc002ucx.2	-	17	3127	c.2635G>T	c.(2635-2637)GTG>TTG	p.V879L	SCN3A_uc002ucy.2_Missense_Mutation_p.V830L|SCN3A_uc002ucz.2_Missense_Mutation_p.V830L|SCN3A_uc002uda.1_Missense_Mutation_p.V699L|SCN3A_uc002udb.1_Missense_Mutation_p.V699L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	879						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	AGAGCCCCCACAGAATTGCCA	0.428000												
WIPF1	7456	broad.mit.edu	37	2	175431818	175431818	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:175431818A>G	uc002uiy.2	-	8	1768	c.1436T>C	c.(1435-1437)CTG>CCG	p.L479P	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.L479P|WIPF1_uc010fqt.1_Missense_Mutation_p.L479P|WIPF1_uc002uiz.2_Missense_Mutation_p.L479P|WIPF1_uc002ujb.1_Missense_Mutation_p.L479P	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	479					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						GTTTCTTGCCAGTTTGCTGGG	0.468000												
TTN	7273	broad.mit.edu	37	2	179407393	179407393	+	Silent	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:179407393A>T	uc010zfg.1	-	297	89708	c.89484T>A	c.(89482-89484)ATT>ATA	p.I29828I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.I23523I|TTN_uc010zfi.1_Silent_p.I23456I|TTN_uc010zfj.1_Silent_p.I23331I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30755							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTACCAAGAATGATAACTT	0.333000												
ZDBF2	57683	broad.mit.edu	37	2	207174303	207174303	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:207174303A>G	uc002vbp.2	+	5	5301	c.5051A>G	c.(5050-5052)CAC>CGC	p.H1684R		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1684							nucleic acid binding|zinc ion binding			ovary(3)	3						CAGAAAGCTCACAAAGAAGCC	0.428000												
RPE	6120	broad.mit.edu	37	2	210884513	210884513	+	Nonstop_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr2:210884513T>C	uc002vdn.2	+	6	690	c.685T>C	c.(685-687)TGA>CGA	p.*229R	RPE_uc002vdm.2_3'UTR|RPE_uc002vdo.2_Nonstop_Mutation_p.*179R|RPE_uc010zjf.1_Nonstop_Mutation_p.*200R|RPE_uc002vdp.2_Nonstop_Mutation_p.*176R|RPE_uc010fup.2_Nonstop_Mutation_p.*161R|RPE_uc002vdq.2_Nonstop_Mutation_p.*179R|RPE_uc002vdr.2_Nonstop_Mutation_p.*144R	NM_199229	NP_954699	Q96AT9	RPE_HUMAN	ribulose-5-phosphate-3-epimerase isoform 1	229					pentose-phosphate shunt	cytosol	metal ion binding|protein homodimerization activity|ribulose-phosphate 3-epimerase activity				0				Epithelial(149;0.00241)|Lung(261;0.041)|all cancers(144;0.0429)|LUSC - Lung squamous cell carcinoma(261;0.0431)		TCTTGATCGGTGAAACCATAA	0.423000												
NINL	22981	broad.mit.edu	37	20	25478911	25478911	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr20:25478911C>T	uc002wux.1	-	9	1178	c.1104G>A	c.(1102-1104)ATG>ATA	p.M368I	NINL_uc010gdn.1_Missense_Mutation_p.M368I|NINL_uc010gdo.1_Missense_Mutation_p.M151I|NINL_uc010ztf.1_Missense_Mutation_p.M384I	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	368					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TGTCCACTGTCATGAGCTCGT	0.612000												
DNMT3B	1789	broad.mit.edu	37	20	31388003	31388003	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr20:31388003G>A	uc002wyc.2	+	17	2125	c.1804G>A	c.(1804-1806)GTC>ATC	p.V602I	DNMT3B_uc010zty.1_RNA|DNMT3B_uc002wyd.2_Missense_Mutation_p.V582I|DNMT3B_uc002wye.2_Missense_Mutation_p.V582I|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.V540I|DNMT3B_uc010zua.1_Missense_Mutation_p.V506I|DNMT3B_uc002wyf.2_Missense_Mutation_p.V594I|DNMT3B_uc002wyg.2_Missense_Mutation_p.V301I|DNMT3B_uc010geg.2_5'Flank|DNMT3B_uc010geh.2_5'Flank	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	602					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						AGGAAAGTACGTCGCTTCTGA	0.483000												
KCNK15	60598	broad.mit.edu	37	20	43374604	43374604	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr20:43374604A>G	uc002xmr.2	+	1	117	c.53A>G	c.(52-54)TAC>TGC	p.Y18C		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	18	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				ACCCTGTGTTACCTGCTGGTG	0.736000												
TSHZ2	128553	broad.mit.edu	37	20	51870079	51870079	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr20:51870079A>C	uc002xwo.2	+	2	1038	c.82A>C	c.(82-84)AAA>CAA	p.K28Q		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	28	Potential.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			ggaggaaataaaagaagagga	0.378000												
FTCD	10841	broad.mit.edu	37	21	47574136	47574136	+	Silent	SNP	C	C	T	rs143451664		TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr21:47574136C>T	uc002zif.2	-	2	209	c.165G>A	c.(163-165)CCG>CCA	p.P55P	FTCD_uc002zig.2_Silent_p.P55P|FTCD_uc002zih.2_Silent_p.P55P|FTCD_uc010gqf.2_Silent_p.P55P|FTCD_uc010gqg.1_5'UTR	NM_006657	NP_006648	O95954	FTCD_HUMAN	formiminotransferase cyclodeaminase	55	Formiminotransferase N-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			pancreas(1)|skin(1)	2	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CCACGCACTCCGGCGGCCCCA	0.657000												
TTLL1	25809	broad.mit.edu	37	22	43442565	43442565	+	Silent	SNP	C	C	T	rs143499869		TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr22:43442565C>T	uc003bdi.2	-	10	1234	c.993G>A	c.(991-993)CCG>CCA	p.P331P	TTLL1_uc010gzh.2_Silent_p.P302P|TTLL1_uc003bdj.2_Silent_p.P217P|TTLL1_uc003bdh.2_Silent_p.P293P	NM_012263	NP_036395	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	331	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			skin(1)	1		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		ACGTGAGAGACGGGGACGCAT	0.512000												
FBLN2	2199	broad.mit.edu	37	3	13659633	13659633	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:13659633T>C	uc011avb.1	+	6	1912	c.1787T>C	c.(1786-1788)CTG>CCG	p.L596P	FBLN2_uc011auz.1_Missense_Mutation_p.L622P|FBLN2_uc011ava.1_Missense_Mutation_p.L596P|FBLN2_uc011avc.1_Missense_Mutation_p.L596P	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	596						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GAGGCCGAGCTGCCGAACAGC	0.602000												
C3orf39	84892	broad.mit.edu	37	3	43122809	43122809	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:43122809T>C	uc003cmq.1	-	2	256	c.115A>G	c.(115-117)AGC>GGC	p.S39G	C3orf39_uc003cmr.1_Missense_Mutation_p.S39G	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	39						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		GCCTGTCGGCTGAGGGCCAGC	0.657000												
GRM2	2912	broad.mit.edu	37	3	51747059	51747059	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:51747059C>T	uc010hlv.2	+	3	1260	c.1021C>T	c.(1021-1023)CGG>TGG	p.R341W	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	341	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GAACAACAGCCGGAACCCCTG	0.617000												
PXK	54899	broad.mit.edu	37	3	58382783	58382783	+	Silent	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:58382783T>C	uc003djz.1	+	10	939	c.840T>C	c.(838-840)CAT>CAC	p.H280H	PXK_uc003djx.1_Silent_p.H280H|PXK_uc003djy.1_Silent_p.H263H|PXK_uc003dka.1_Silent_p.H280H|PXK_uc003dkb.1_Silent_p.H197H|PXK_uc003dkc.1_Silent_p.H263H|PXK_uc011bfe.1_Silent_p.H247H|PXK_uc010hnj.1_Silent_p.H247H|PXK_uc003dkd.1_Silent_p.H143H|PXK_uc010hnk.1_Silent_p.H54H	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	280	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		AGTTTCTTCATGACAAGGGAT	0.418000												
ROBO1	6091	broad.mit.edu	37	3	79174627	79174627	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:79174627C>T	uc003dqe.2	-	3	359	c.151G>A	c.(151-153)GAC>AAC	p.D51N		NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	51	Extracellular (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AGCGAATTGTCATCGTTATCA	0.502000												
IMPG2	50939	broad.mit.edu	37	3	100951810	100951810	+	Silent	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:100951810A>G	uc003duq.1	-	15	3251	c.3048T>C	c.(3046-3048)TTT>TTC	p.F1016F	IMPG2_uc011bhe.1_Silent_p.F879F|IMPG2_uc010hpj.1_RNA	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	1016	Extracellular (Potential).|EGF-like 1.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TACAGGCCTGAAACTTGCAAG	0.438000												
FAM55C	91775	broad.mit.edu	37	3	101540654	101540654	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:101540654G>A	uc003dvn.2	+	8	2173	c.1536G>A	c.(1534-1536)ATG>ATA	p.M512I	FAM55C_uc010hpn.2_Missense_Mutation_p.M512I	NM_145037	NP_659474	Q969Y0	FA55C_HUMAN	hypothetical protein LOC91775 precursor	512						extracellular region				ovary(1)|pancreas(1)|skin(1)	3						TTCGGAGGATGTTCTCAGGGG	0.537000												
KIAA1407	57577	broad.mit.edu	37	3	113761657	113761657	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:113761657A>G	uc003eax.2	-	4	455	c.308T>C	c.(307-309)CTT>CCT	p.L103P	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.L81P|KIAA1407_uc011bip.1_Missense_Mutation_p.L90P	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	103										ovary(2)	2						TTCTTGCTTAAGTTTGGTGTC	0.368000												
FSTL1	11167	broad.mit.edu	37	3	120115829	120115829	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:120115829C>A	uc003eds.2	-	11	1072	c.897G>T	c.(895-897)AAG>AAT	p.K299N	FSTL1_uc011bjh.1_Missense_Mutation_p.K264N|MIR198_hsa-mir-198|MI0000240_5'Flank	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	299					BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		CTCTCTTGGTCTTTTCAGCTG	0.403000												
HSPBAP1	79663	broad.mit.edu	37	3	122459454	122459454	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:122459454G>A	uc003efu.1	-	8	1328	c.1205C>T	c.(1204-1206)CCG>CTG	p.P402L	HSPBAP1_uc003eft.1_Missense_Mutation_p.P113L	NM_024610	NP_078886	Q96EW2	HBAP1_HUMAN	Hspb associated protein 1	402						cytoplasm				ovary(1)|lung(1)	2				GBM - Glioblastoma multiforme(114;0.0531)		TTCTGAAGGCGGTTCTTCGGA	0.493000												
PLXND1	23129	broad.mit.edu	37	3	129277407	129277407	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:129277407C>T	uc003emx.2	-	33	5409	c.5309G>A	c.(5308-5310)CGG>CAG	p.R1770Q	PLXND1_uc003emw.2_5'UTR|PLXND1_uc011blb.1_Missense_Mutation_p.R439Q	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1770	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CACCCAGAACCGGAGAGGAAG	0.562000												
COL6A6	131873	broad.mit.edu	37	3	130354547	130354547	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:130354547A>T	uc010htl.2	+	27	5064	c.5033A>T	c.(5032-5034)GAG>GTG	p.E1678V	COL6A6_uc003eni.3_5'UTR	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1678	Triple-helical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						ATTTAGGGTGAGATTGGGGAC	0.358000												
DZIP1L	199221	broad.mit.edu	37	3	137822699	137822699	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:137822699T>G	uc003erq.2	-	2	478	c.115A>C	c.(115-117)AGC>CGC	p.S39R	DZIP1L_uc003err.1_Missense_Mutation_p.S39R	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	39						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						TCCAGGGTGCTAATGCGTCTC	0.592000												
PAQR9	344838	broad.mit.edu	37	3	142681913	142681913	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:142681913G>A	uc003evg.2	-	1	266	c.266C>T	c.(265-267)ACG>ATG	p.T89M	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	89	Helical; (Potential).					integral to membrane	receptor activity				0						GATGAAGTGCGTCCAGAAGTT	0.632000												
USP13	8975	broad.mit.edu	37	3	179460107	179460107	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr3:179460107A>T	uc003fkh.2	+	12	1584	c.1503A>T	c.(1501-1503)TTA>TTT	p.L501F	USP13_uc003fkf.2_Missense_Mutation_p.L501F	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	501					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TGATGCAGTTACCTGTGGCCA	0.488000												
ANK2	287	broad.mit.edu	37	4	114294571	114294571	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr4:114294571G>A	uc003ibe.3	+	45	11925	c.11825G>A	c.(11824-11826)CGT>CAT	p.R3942H	ANK2_uc003ibd.3_Missense_Mutation_p.R1848H|ANK2_uc003ibf.3_Missense_Mutation_p.R1857H|ANK2_uc011cgc.1_Missense_Mutation_p.R1033H|ANK2_uc003ibg.3_Missense_Mutation_p.R872H|ANK2_uc003ibh.3_Missense_Mutation_p.R562H|ANK2_uc011cgd.1_Missense_Mutation_p.R1244H|ANK2_uc010imr.2_Missense_Mutation_p.R24H|ANK2_uc010ims.2_Missense_Mutation_p.R24H	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3909					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GTTATAAAGCGTGTTGTATTG	0.448000												
C4orf31	79625	broad.mit.edu	37	4	121957572	121957572	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr4:121957572G>A	uc003idq.1	-	4	2081	c.1554C>T	c.(1552-1554)TTC>TTT	p.F518F		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	518	Fibronectin type-III 2.										0						TTTGACTGTGGAAATATTTAC	0.408000												
PDGFC	56034	broad.mit.edu	37	4	157771489	157771489	+	Silent	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr4:157771489A>C	uc003iph.1	-	2	689	c.198T>G	c.(196-198)ACT>ACG	p.T66T	PDGFC_uc003ipi.1_5'UTR|PDGFC_uc011cis.1_Intron|PDGFC_uc011cir.1_5'UTR	NM_016205	NP_057289	Q9NRA1	PDGFC_HUMAN	platelet-derived growth factor C precursor	66	CUB.				central nervous system development|platelet-derived growth factor receptor signaling pathway|positive regulation of cell division|positive regulation of DNA replication|positive regulation of fibroblast proliferation|vascular endothelial growth factor receptor signaling pathway	endoplasmic reticulum lumen|extracellular space|Golgi membrane|nucleus	cell surface binding|growth factor activity|platelet-derived growth factor receptor binding|protein homodimerization activity			ovary(1)|lung(1)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.08)|Kidney(143;0.0977)|COAD - Colon adenocarcinoma(41;0.212)		TTCTTGGATAAGTATGAGGAA	0.383000												
ADCY2	108	broad.mit.edu	37	5	7706939	7706939	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr5:7706939C>A	uc003jdz.1	+	8	1259	c.1192C>A	c.(1192-1194)CTG>ATG	p.L398M	ADCY2_uc011cmo.1_Missense_Mutation_p.L218M	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	398	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CGTGATTGGTCTGCAGAAGTG	0.507000												
CENPH	64946	broad.mit.edu	37	5	68498798	68498798	+	Splice_Site	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr5:68498798G>A	uc003jvp.2	+	7	574	c.487_splice	c.e7+1	p.Q163_splice	CENPH_uc010ixc.2_Splice_Site_p.Q144_splice	NM_022909	NP_075060	Q9H3R5	CENPH_HUMAN	centromere protein H						cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|kinetochore organization|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	kinetochore binding|protein binding			large_intestine(1)	1		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.41e-56)|Epithelial(20;1.29e-52)|all cancers(19;3.15e-48)|Lung(70;0.0178)		AAGAGATTGCGTATGTAGAAC	0.323000												
VCAN	1462	broad.mit.edu	37	5	82816102	82816102	+	Silent	SNP	T	T	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr5:82816102T>A	uc003kii.3	+	7	2333	c.1977T>A	c.(1975-1977)TCT>TCA	p.S659S	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Silent_p.S659S|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	659	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTCCTTATTCTGGTGATAAAA	0.348000												
GPR98	84059	broad.mit.edu	37	5	90136635	90136635	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr5:90136635A>G	uc003kju.2	+	78	16948	c.16852A>G	c.(16852-16854)ACT>GCT	p.T5618A	GPR98_uc003kjt.2_Missense_Mutation_p.T3324A|GPR98_uc003kjw.2_Missense_Mutation_p.T1279A	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5618	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGCCAACATCACTCTTGTCTC	0.443000												
RAPGEF6	51735	broad.mit.edu	37	5	130828379	130828379	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr5:130828379G>A	uc003kvn.1	-	14	1833	c.1627C>T	c.(1627-1629)CAA>TAA	p.Q543*	RAPGEF6_uc003kvp.1_Nonsense_Mutation_p.Q593*|RAPGEF6_uc003kvo.1_Nonsense_Mutation_p.Q543*|RAPGEF6_uc010jdi.1_Nonsense_Mutation_p.Q543*|RAPGEF6_uc010jdj.1_Nonsense_Mutation_p.Q543*|RAPGEF6_uc003kvq.2_Nonsense_Mutation_p.Q260*|RAPGEF6_uc003kvr.2_Nonsense_Mutation_p.Q543*|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Nonsense_Mutation_p.Q543*	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	543	PDZ.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		AGGCTGAATTGTAGAGGGGAC	0.473000												
PCDHB9	56127	broad.mit.edu	37	5	140569226	140569226	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr5:140569226G>T	uc003liw.1	+	3	2335	c.2335G>T	c.(2335-2337)GGT>TGT	p.G779C	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	779	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCCCATAGGGGTGGGAAAGA	0.443000												
DOCK2	1794	broad.mit.edu	37	5	169423161	169423161	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr5:169423161A>C	uc003maf.2	+	30	3145	c.3065A>C	c.(3064-3066)GAG>GCG	p.E1022A	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E514A	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1022	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACGAACTTTGAGTTCCAGGTG	0.502000												
TBC1D9B	23061	broad.mit.edu	37	5	179292354	179292354	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr5:179292354T>C	uc003mlh.2	-	21	3009	c.2972A>G	c.(2971-2973)AAG>AGG	p.K991R	TBC1D9B_uc003mli.2_Missense_Mutation_p.K974R|TBC1D9B_uc003mlj.2_Missense_Mutation_p.K973R|TBC1D9B_uc003mlf.2_Missense_Mutation_p.K65R|TBC1D9B_uc003mlg.2_Missense_Mutation_p.K150R|TBC1D9B_uc011dgv.1_Missense_Mutation_p.K150R	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	991						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGGTCCCCTTCTCCTCTGC	0.527000												
SCAND3	114821	broad.mit.edu	37	6	28543668	28543668	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr6:28543668G>A	uc003nlo.2	-	3	1432	c.814C>T	c.(814-816)CGC>TGC	p.R272C		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	272	Potential.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTAGCCAAGCGACGGTAGTCA	0.353000												
RIMS1	22999	broad.mit.edu	37	6	72974729	72974729	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr6:72974729G>A	uc003pga.2	+	20	3245	c.3168G>A	c.(3166-3168)CAG>CAA	p.Q1056Q	RIMS1_uc011dyb.1_Intron|RIMS1_uc003pgc.2_Intron|RIMS1_uc010kaq.2_Intron|RIMS1_uc011dyc.1_Intron|RIMS1_uc010kar.2_Intron|RIMS1_uc011dyd.1_Intron|RIMS1_uc003pgf.2_Intron|RIMS1_uc003pgg.2_Intron|RIMS1_uc003pgi.2_Intron|RIMS1_uc003pgh.2_Intron|RIMS1_uc003pgd.2_Silent_p.Q273Q|RIMS1_uc003pge.2_Intron|RIMS1_uc011dye.1_Intron|RIMS1_uc011dyf.1_Intron|RIMS1_uc010kas.1_Intron	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1056					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CTTTATTACAGAGCAGTTCTC	0.373000												
KCNQ5	56479	broad.mit.edu	37	6	73904338	73904338	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr6:73904338C>T	uc003pgk.2	+	14	2347	c.2000C>T	c.(1999-2001)TCG>TTG	p.S667L	KCNQ5_uc011dyh.1_Missense_Mutation_p.S686L|KCNQ5_uc011dyi.1_Missense_Mutation_p.S677L|KCNQ5_uc010kat.2_Missense_Mutation_p.S658L|KCNQ5_uc011dyj.1_Missense_Mutation_p.S557L|KCNQ5_uc011dyk.1_Missense_Mutation_p.S417L	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	667					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		AAAGATCTTTCGGGTTCCGCA	0.502000												
ASCC3	10973	broad.mit.edu	37	6	101103582	101103582	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr6:101103582G>A	uc003pqk.2	-	17	3145	c.2816C>T	c.(2815-2817)GCT>GTT	p.A939V	ASCC3_uc011eai.1_Missense_Mutation_p.A841V	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	939					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TACCTGATAAGCCTTGTGACT	0.348000												
REV3L	5980	broad.mit.edu	37	6	111696720	111696720	+	Silent	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr6:111696720A>T	uc003puy.3	-	13	3161	c.2838T>A	c.(2836-2838)CCT>CCA	p.P946P	REV3L_uc003pux.3_Silent_p.P868P|REV3L_uc003puz.3_Silent_p.P868P	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	946					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CCATGGGATGAGGTAGACTAA	0.358000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage				
HSF2	3298	broad.mit.edu	37	6	122740353	122740353	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr6:122740353T>G	uc003pyu.2	+	6	759	c.572T>G	c.(571-573)CTT>CGT	p.L191R	HSF2_uc003pyt.3_Missense_Mutation_p.L191R|HSF2_uc003pyv.2_Missense_Mutation_p.L191R	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	191	Hydrophobic repeat HR-A/B.				response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		AATAACCAACTTGTGAGTTTA	0.274000												
SYNE1	23345	broad.mit.edu	37	6	152551776	152551776	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr6:152551776A>T	uc010kiw.2	-	115	21703	c.21101T>A	c.(21100-21102)CTG>CAG	p.L7034Q	SYNE1_uc010kiv.2_Missense_Mutation_p.L1558Q|SYNE1_uc003qos.3_Missense_Mutation_p.L1558Q|SYNE1_uc003qot.3_Missense_Mutation_p.L6963Q|SYNE1_uc003qou.3_Missense_Mutation_p.L7034Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7034	Cytoplasmic (Potential).|Spectrin 22.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCATGTTTTCAGACATTGTAC	0.353000										HNSCC(10;0.0054)		
SP8	221833	broad.mit.edu	37	7	20824641	20824641	+	Silent	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr7:20824641C>T	uc003suy.2	-	3	982	c.741G>A	c.(739-741)CCG>CCA	p.P247P	SP8_uc003suz.2_Silent_p.P265P	NM_198956	NP_945194	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor isoform 2	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						AGCCTCCGAGCGGCGAGTGCA	0.716000												
NOD1	10392	broad.mit.edu	37	7	30491122	30491122	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr7:30491122G>A	uc003tav.2	-	6	2434	c.1911C>T	c.(1909-1911)CGC>CGT	p.R637R		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	637	LRR 1.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						CGACCTGAACGCGGGGCAGGC	0.637000												
PKD1L1	168507	broad.mit.edu	37	7	47894629	47894629	+	Silent	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr7:47894629C>T	uc003tny.1	-	30	4710	c.4710G>A	c.(4708-4710)AGG>AGA	p.R1570R		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1570	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TTTTATTTCTCCTATTATCCT	0.358000												
PCLO	27445	broad.mit.edu	37	7	82545323	82545323	+	Silent	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr7:82545323C>T	uc003uhx.2	-	7	12268	c.11979G>A	c.(11977-11979)ACG>ACA	p.T3993T	PCLO_uc003uhv.2_Silent_p.T3993T|PCLO_uc010lec.2_Silent_p.T958T	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3924					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATGTGTTATCCGTAGAAACAG	0.403000												
PCLO	27445	broad.mit.edu	37	7	82584206	82584206	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr7:82584206A>C	uc003uhx.2	-	5	6352	c.6063T>G	c.(6061-6063)CAT>CAG	p.H2021Q	PCLO_uc003uhv.2_Missense_Mutation_p.H2021Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1952					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCACAACAGAATGTAAGCTTT	0.378000												
PTCD1	26024	broad.mit.edu	37	7	99027390	99027390	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr7:99027390T>C	uc003uqh.2	-	4	765	c.634A>G	c.(634-636)ACG>GCG	p.T212A	PTCD1_uc011kiw.1_Missense_Mutation_p.T261A	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	212	PPR 3.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			AACAGGGCCGTGTAGGTGGCG	0.617000												
GIGYF1	64599	broad.mit.edu	37	7	100281681	100281681	+	Silent	SNP	C	C	T	rs138722511	byFrequency	TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr7:100281681C>T	uc003uwg.1	-	15	2839	c.1830G>A	c.(1828-1830)ACG>ACA	p.T610T		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	610	Gln-rich.									large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					GCAGGAATGCCGTGAGCTGCT	0.697000												
OR2F1	26211	broad.mit.edu	37	7	143657492	143657492	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr7:143657492G>A	uc003wds.1	+	1	473	c.429G>A	c.(427-429)AGG>AGA	p.R143R		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					TGTGTGCTAGGTTGGCCATCA	0.527000												
CSGALNACT1	55790	broad.mit.edu	37	8	19362744	19362744	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:19362744T>C	uc011kyn.1	-	4	1666	c.602A>G	c.(601-603)CAC>CGC	p.H201R	CSGALNACT1_uc011kyo.1_Missense_Mutation_p.H201R|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Missense_Mutation_p.H200R|CSGALNACT1_uc003wzh.2_RNA	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	201	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		GTAAGGACGGTGATTGGGGCT	0.527000												
ADRA1A	148	broad.mit.edu	37	8	26628025	26628025	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:26628025T>C	uc003xfh.1	-	2	1478	c.1042A>G	c.(1042-1044)AGA>GGA	p.R348G	ADRA1A_uc003xfc.1_Missense_Mutation_p.R348G|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.R348G|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.R348G	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	348	Cytoplasmic (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	GACTGCTTTCTGCAGAGACAC	0.542000												
GINS4	84296	broad.mit.edu	37	8	41399380	41399380	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:41399380A>C	uc003xnx.2	+	7	747	c.537A>C	c.(535-537)CAA>CAC	p.Q179H	GINS4_uc003xny.2_Missense_Mutation_p.Q179H	NM_032336	NP_115712	Q9BRT9	SLD5_HUMAN	GINS complex subunit 4	179	Important for GINS complex assembly.				DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				skin(1)	1	Ovarian(28;0.014)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.00732)|Lung NSC(58;0.0207)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00329)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			GAGAACGACAAGAAAACATAC	0.488000												
ARMC1	55156	broad.mit.edu	37	8	66525479	66525479	+	Silent	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:66525479C>A	uc003xvl.2	-	4	700	c.465G>T	c.(463-465)ACG>ACT	p.T155T	ARMC1_uc011leo.1_Intron	NM_018120	NP_060590	Q9NVT9	ARMC1_HUMAN	armadillo repeat-containing protein	155					metal ion transport		metal ion binding			skin(1)	1			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			CAGACCTTACCGTATCATCAA	0.373000												
DPY19L4	286148	broad.mit.edu	37	8	95793379	95793379	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:95793379T>C	uc003ygx.2	+	16	1824	c.1700T>C	c.(1699-1701)CTT>CCT	p.L567P		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	567						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					ACAGTGGAACTTATGACCTGG	0.303000												
ZNF623	9831	broad.mit.edu	37	8	144733376	144733376	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:144733376A>G	uc003yzd.2	+	1	1423	c.1334A>G	c.(1333-1335)AAG>AGG	p.K445R	ZNF623_uc011lkp.1_Missense_Mutation_p.K405R|ZNF623_uc003yzc.2_Missense_Mutation_p.K405R	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	445	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CAGAGCTCCAAGCTGCTTCTG	0.483000												
PARP10	84875	broad.mit.edu	37	8	145058498	145058498	+	Silent	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:145058498G>A	uc003zal.3	-	6	1668	c.1560C>T	c.(1558-1560)AGC>AGT	p.S520S	PARP10_uc003zak.3_Silent_p.S226S|PARP10_uc011lku.1_Silent_p.S532S|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.S520S	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	520						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GAAACCTGGCGCTGCCCGGGT	0.647000												
PARP10	84875	broad.mit.edu	37	8	145059121	145059121	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:145059121C>G	uc003zal.3	-	5	1157	c.1049G>C	c.(1048-1050)AGC>ACC	p.S350T	PARP10_uc003zak.3_Missense_Mutation_p.S56T|PARP10_uc011lku.1_Missense_Mutation_p.S362T|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.S350T|PARP10_uc010mfn.1_Missense_Mutation_p.S265T|PARP10_uc010mfo.1_3'UTR	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	350						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGCATCGAGCTGACTTGCTC	0.627000												
PPP1R16A	84988	broad.mit.edu	37	8	145722828	145722828	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr8:145722828T>A	uc003zdd.2	+	2	1164	c.251T>A	c.(250-252)CTG>CAG	p.L84Q	uc003zde.1_Missense_Mutation_p.R96W|PPP1R16A_uc003zdf.2_Missense_Mutation_p.L84Q	NM_032902	NP_116291	Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	84	ANK 1.					plasma membrane	protein binding				0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			CGAAATGACCTGGAAGAAGGT	0.662000												
TPD52L3	89882	broad.mit.edu	37	9	6328606	6328606	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr9:6328606C>A	uc003zjw.2	+	1	232	c.11C>A	c.(10-12)GCC>GAC	p.A4D	TPD52L3_uc003zjv.2_Missense_Mutation_p.A4D|TPD52L3_uc003zjx.1_Missense_Mutation_p.A4D	NM_033516	NP_277051	Q96J77	TPD55_HUMAN	protein kinase NYD-SP25 isoform 1	4							protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0198)|Lung(218;0.1)		ATGCCACATGCCAGGACAGAG	0.473000												
ELAVL2	1993	broad.mit.edu	37	9	23762120	23762120	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr9:23762120T>C	uc003zpu.2	-	2	388	c.113A>G	c.(112-114)AAG>AGG	p.K38R	ELAVL2_uc003zps.2_Missense_Mutation_p.K38R|ELAVL2_uc003zpt.2_Missense_Mutation_p.K38R|ELAVL2_uc003zpv.2_Missense_Mutation_p.K38R|ELAVL2_uc003zpw.2_Missense_Mutation_p.K38R	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	38					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TAAGTTGGTCTTGCTGTCTTC	0.443000												
C9orf84	158401	broad.mit.edu	37	9	114466182	114466182	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr9:114466182T>G	uc004bfr.2	-	20	2889	c.2754A>C	c.(2752-2754)GAA>GAC	p.E918D	C9orf84_uc011lwt.1_Intron|C9orf84_uc004bfq.2_Missense_Mutation_p.E879D|C9orf84_uc010mug.2_Missense_Mutation_p.E829D	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	918										ovary(2)	2						TGGCAGTGTGTTCATCAATTG	0.318000												
TLR4	7099	broad.mit.edu	37	9	120475601	120475601	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr9:120475601A>C	uc004bjz.2	+	3	1486	c.1195A>C	c.(1195-1197)ACC>CCC	p.T399P	TLR4_uc004bka.2_Missense_Mutation_p.T359P|TLR4_uc004bkb.2_Missense_Mutation_p.T199P	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	399	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						TTTTGGGACAACCAGCCTAAA	0.388000												
OR1B1	347169	broad.mit.edu	37	9	125391418	125391418	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr9:125391418G>T	uc011lyz.1	-	1	397	c.397C>A	c.(397-399)CAC>AAC	p.H133N		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	133	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAAGCATAGTGCAGGGGGTCA	0.502000												
CERCAM	51148	broad.mit.edu	37	9	131196429	131196429	+	Missense_Mutation	SNP	C	C	T	rs148628855	byFrequency	TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr9:131196429C>T	uc004buz.3	+	10	1650	c.1252C>T	c.(1252-1254)CGC>TGC	p.R418C	CERCAM_uc004buy.1_Missense_Mutation_p.R340C|CERCAM_uc010mxz.2_Missense_Mutation_p.R340C|CERCAM_uc010mya.1_Missense_Mutation_p.R259C	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	418					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						GGATGACGTGCGCTTTGAGAG	0.607000												
COBRA1	25920	broad.mit.edu	37	9	140151447	140151447	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr9:140151447G>T	uc004cmm.3	+	4	741	c.538G>T	c.(538-540)GAG>TAG	p.E180*		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	180					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		CTTCAGTACAGAGCTCTCTGT	0.617000												
RAI2	10742	broad.mit.edu	37	X	17819536	17819536	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chrX:17819536C>T	uc004cyf.2	-	3	1165	c.595G>A	c.(595-597)GGG>AGG	p.G199R	RAI2_uc004cyg.2_Missense_Mutation_p.G199R|RAI2_uc010nfa.2_Missense_Mutation_p.G199R|RAI2_uc004cyh.3_Missense_Mutation_p.G199R|RAI2_uc011miy.1_Missense_Mutation_p.G149R	NM_021785	NP_068557	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	199					embryo development					ovary(1)|breast(1)	2	Hepatocellular(33;0.183)					GGTGGGGGCCCGAGAGTGCCC	0.647000												
MAGEB18	286514	broad.mit.edu	37	X	26157600	26157600	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chrX:26157600A>C	uc004dbq.1	+	2	685	c.498A>C	c.(496-498)GAA>GAC	p.E166D		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	166	MAGE.						protein binding			central_nervous_system(1)	1						ATTTGAAGGAAGTGGATCCCA	0.433000												
IL1RAPL2	26280	broad.mit.edu	37	X	104728346	104728346	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chrX:104728346G>A	uc004elz.1	+	6	1495	c.739G>A	c.(739-741)GAG>AAG	p.E247K		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	247	Ig-like C2-type 3.|Extracellular (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						GTTCCCCATGGAGAATCAGCC	0.408000												
ODZ1	10178	broad.mit.edu	37	X	124028194	124028194	+	Silent	SNP	T	T	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chrX:124028194T>C	uc004euj.2	-	3	550	c.486A>G	c.(484-486)AAA>AAG	p.K162K	ODZ1_uc011muj.1_Silent_p.K162K|ODZ1_uc010nqy.2_Silent_p.K162K	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	162	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CAGGAGAGAATTTGAAACCTG	0.393000												
ACTRT1	139741	broad.mit.edu	37	X	127185978	127185978	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chrX:127185978A>C	uc004eum.2	-	1	405	c.208T>G	c.(208-210)TTG>GTG	p.L70V		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	70						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						GGGTAGTGCAAATGTAGGGCC	0.478000												
FLNA	2316	broad.mit.edu	37	X	153587984	153587984	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chrX:153587984C>A	uc004fkk.2	-	24	4259	c.4010G>T	c.(4009-4011)GGC>GTC	p.G1337V	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.G1337V	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1337	Filamin 11.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CACGGGACTGCCGTCATAGGT	0.706000												
CRHR1	1394	broad.mit.edu	37	17	43908305	43908308	+	Splice_Site	DEL	AAGT	AAGT	-			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:43908304_43908307GAAGT>G	uc010dap.3	+	9	1122	c.857_splice	c.e9+1	p.K286_splice	CRHR1_uc010wjx.2_Splice_Site_p.K82_splice|CRHR1_uc002ijp.3_Splice_Site_p.K156_splice|CRHR1_uc002ijm.3_Splice_Site_p.K257_splice|CRHR1_uc002ijn.3_Splice_Site_p.K217_splice|CRHR1_uc010dar.3_Splice_Site_p.K257_splice|CRHR1_uc010dao.3_Splice_Site_p.K156_splice|CRHR1_uc010daq.3_Splice_Site_p.K82_splice|CRHR1_uc021tyu.1_Splice_Site_p.K82_splice	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	Homo sapiens corticotropin releasing hormone receptor 1 (CRHR1), transcript variant 1, mRNA.	286					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		ACGACAATGAGAAGTAAGTCATCT	0.588												
PRM3	58531	broad.mit.edu	37	16	11367275	11367277	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr16:11367275_11367277delCCT	uc002dat.1	-	1	176_178	c.176_178delAGG	c.(175-180)GAGGGG>GGG	p.E59del	C16orf75_uc002daq.1_Intron	NM_021247	NP_067070	Q9NNZ6	PRM3_HUMAN	protamine 3	59	Asp/Glu-rich (highly acidic).				cell differentiation|chromosome condensation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding				0						tcctcttccccctcctcctcctc	0.468												
CRHR1	1394	broad.mit.edu	37	17	43908305	43908308	+	Splice_Site	DEL	AAGT	AAGT	-			TCGA-BR-7723-01A-11D-2053-08	TCGA-BR-7723-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5946cac-08ce-4512-823d-6c2fa6e73150	daa716c5-0804-49e0-88e8-811cf079546d	g.chr17:43908304_43908307GAAGT>G	uc010dap.3	+	9	1122	c.857_splice	c.e9+1	p.K286_splice	CRHR1_uc010wjx.2_Splice_Site_p.K82_splice|CRHR1_uc002ijp.3_Splice_Site_p.K156_splice|CRHR1_uc002ijm.3_Splice_Site_p.K257_splice|CRHR1_uc002ijn.3_Splice_Site_p.K217_splice|CRHR1_uc010dar.3_Splice_Site_p.K257_splice|CRHR1_uc010dao.3_Splice_Site_p.K156_splice|CRHR1_uc010daq.3_Splice_Site_p.K82_splice|CRHR1_uc021tyu.1_Splice_Site_p.K82_splice	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	Homo sapiens corticotropin releasing hormone receptor 1 (CRHR1), transcript variant 1, mRNA.	286					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		ACGACAATGAGAAGTAAGTCATCT	0.588