Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
YTHDF2	51441	broad.mit.edu	37	1	29070218	29070218	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr1:29070218A>G	uc001brc.2	+	4	1933	c.1436A>G	c.(1435-1437)TAC>TGC	p.Y479C	YTHDF2_uc001brd.2_Missense_Mutation_p.Y476C|YTHDF2_uc010ofx.1_Missense_Mutation_p.Y429C|YTHDF2_uc001bre.2_Missense_Mutation_p.Y429C	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	479	YTH.				humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGTGGACTACAACACATGT	0.493000												
STK40	83931	broad.mit.edu	37	1	36809854	36809854	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr1:36809854G>A	uc001cak.1	-	9	1158	c.751C>T	c.(751-753)CGT>TGT	p.R251C	STK40_uc001cal.1_Missense_Mutation_p.R256C|STK40_uc001cam.1_Missense_Mutation_p.R251C|STK40_uc009vva.1_Missense_Mutation_p.R251C|STK40_uc001can.1_Missense_Mutation_p.R251C	NM_032017	NP_114406	Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	251	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)				GGCTTGCCACGGTACGGCCGG	0.637000												
C1orf177	163747	broad.mit.edu	37	1	55277794	55277794	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr1:55277794C>T	uc001cyb.3	+	6	748	c.694C>T	c.(694-696)CGC>TGC	p.R232C	C1orf177_uc001cya.3_Missense_Mutation_p.R232C	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	232											0						CGTCGGCACCCGCGGCCCCTA	0.577000												
OR6Y1	391112	broad.mit.edu	37	1	158517584	158517584	+	Silent	SNP	A	A	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr1:158517584A>T	uc010pil.1	-	1	312	c.312T>A	c.(310-312)ACT>ACA	p.T104T		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	104	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGTAAAGTTGAGTCATGCAGC	0.448000												
CACNA1E	777	broad.mit.edu	37	1	181724450	181724450	+	Silent	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr1:181724450C>T	uc001gow.2	+	28	4071	c.3906C>T	c.(3904-3906)ATC>ATT	p.I1302I	CACNA1E_uc009wxs.2_Silent_p.I1190I|CACNA1E_uc001gox.1_Silent_p.I528I|CACNA1E_uc009wxt.2_Silent_p.I528I	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1302	III.|Helical; Name=S5 of repeat III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TCATGTTCATCTTTGCTGTCA	0.483000												
RAB3GAP2	25782	broad.mit.edu	37	1	220357408	220357408	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr1:220357408A>C	uc010puk.1	-	19	2132	c.1968T>G	c.(1966-1968)GAT>GAG	p.D656E	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.D236E	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	656					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		CTAAATGAAAATCAAGGGAAT	0.299000												
ANO9	338440	broad.mit.edu	37	11	419621	419621	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr11:419621C>T	uc001lpi.2	-	20	1980	c.1895G>A	c.(1894-1896)CGC>CAC	p.R632H	SIGIRR_uc001lpf.2_5'Flank|SIGIRR_uc001lpe.1_5'Flank|ANO9_uc001lph.2_Missense_Mutation_p.R325H|ANO9_uc010qvv.1_Missense_Mutation_p.R488H	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	632	Extracellular (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TGGGCTATAGCGGTACTTGTA	0.567000												
OR10A4	283297	broad.mit.edu	37	11	6898608	6898608	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr11:6898608G>T	uc010rat.1	+	1	730	c.730G>T	c.(730-732)GCC>TCC	p.A244S		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CACCTGTTCCGCCCACCTCTT	0.527000												
MRVI1	10335	broad.mit.edu	37	11	10673689	10673689	+	Silent	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr11:10673689G>A	uc010rcc.1	-	2	494	c.108C>T	c.(106-108)GAC>GAT	p.D36D	MRVI1_uc001miw.2_Silent_p.D27D|MRVI1_uc010rcb.1_Silent_p.D27D|MRVI1_uc009ygb.1_Translation_Start_Site|MRVI1_uc001mix.2_Translation_Start_Site|MRVI1_uc001miz.2_Intron|MRVI1_uc009ygc.1_Intron|MRVI1_uc010rcd.1_Silent_p.D36D|MRVI1_uc009ygd.1_Intron	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	27					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CCTCCGCTGCGTCAGCCCCAA	0.647000												
METT5D1	196074	broad.mit.edu	37	11	28318379	28318379	+	Missense_Mutation	SNP	G	G	A	rs145080229		TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr11:28318379G>A	uc001msh.2	+	6	1134	c.679G>A	c.(679-681)GGG>AGG	p.G227R	METT5D1_uc001msg.2_Missense_Mutation_p.G227R|METT5D1_uc001mse.2_Missense_Mutation_p.R212Q|METT5D1_uc001msi.2_Missense_Mutation_p.G24R	NM_001113528	NP_001107000	A6NJ78	MET15_HUMAN	methyltransferase 5 domain containing 1 isoform	227							methyltransferase activity				0						AAGAACATACGGGGAGGAGAA	0.507000												
FOLH1B	219595	broad.mit.edu	37	11	89395322	89395322	+	Translation_Start_Site	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr11:89395322C>T	uc001pda.2	+	2	433	c.-93C>T	c.(-95--91)TACGC>TATGC			NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TTTCAGAATACGCTTATAGGC	0.328000												
CUL5	8065	broad.mit.edu	37	11	107960310	107960310	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr11:107960310C>T	uc001pjv.2	+	13	2070	c.1403C>T	c.(1402-1404)GCC>GTC	p.A468V	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	468					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		GACATCTCTGCCGATAGTGAA	0.308000												
DSCAML1	57453	broad.mit.edu	37	11	117299181	117299181	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr11:117299181C>T	uc001prh.1	-	33	6207	c.6205G>A	c.(6205-6207)GAG>AAG	p.E2069K		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	2009	Cytoplasmic (Potential).|Pro-rich.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CGTGGAGGCTCGGTGCTGGGG	0.736000												
ALDH1L2	160428	broad.mit.edu	37	12	105433512	105433512	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr12:105433512A>G	uc001tlc.2	-	17	2151	c.2024T>C	c.(2023-2025)ATT>ACT	p.I675T	ALDH1L2_uc009zuo.2_Missense_Mutation_p.I130T|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	675	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						CTGTTTGCCAATAGGAGTGGA	0.393000												
TMEM132D	121256	broad.mit.edu	37	12	129563254	129563254	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr12:129563254G>A	uc009zyl.1	-	8	2268	c.1940C>T	c.(1939-1941)TCA>TTA	p.S647L	TMEM132D_uc001uia.2_Missense_Mutation_p.S185L	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	647	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GATGGTGTCTGACAGAGGAGA	0.567000												
TMEM132D	121256	broad.mit.edu	37	12	130185232	130185232	+	Silent	SNP	G	G	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr12:130185232G>T	uc009zyl.1	-	2	419	c.91C>A	c.(91-93)CGA>AGA	p.R31R		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	31	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGGATCCCTCGACCTTCCGTC	0.443000												
TMCO3	55002	broad.mit.edu	37	13	114193756	114193756	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr13:114193756G>A	uc001vtu.3	+	10	1985	c.1624G>A	c.(1624-1626)GAG>AAG	p.E542K		NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	542						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			CGTGGTCACCGAGGAGATCGC	0.577000												
SPG11	80208	broad.mit.edu	37	15	44913993	44913993	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr15:44913993G>A	uc001ztx.2	-	14	2615	c.2584C>T	c.(2584-2586)CAA>TAA	p.Q862*	SPG11_uc010ueh.1_Nonsense_Mutation_p.Q862*|SPG11_uc010uei.1_Nonsense_Mutation_p.Q862*|SPG11_uc001ztz.1_5'Flank	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	862	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		ATGGATTCTTGTGTTAGTTGA	0.373000												
HCN4	10021	broad.mit.edu	37	15	73617682	73617682	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr15:73617682T>A	uc002avp.2	-	5	2688	c.1694A>T	c.(1693-1695)GAC>GTC	p.D565V		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	565	Cytoplasmic (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		GCTCTCCTCGTCGAACATCTT	0.657000												
NARFL	64428	broad.mit.edu	37	16	780985	780985	+	Silent	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr16:780985C>T	uc002cjr.2	-	10	1062	c.1050G>A	c.(1048-1050)CAG>CAA	p.Q350Q	NARFL_uc002cjp.2_Silent_p.Q248Q|NARFL_uc002cjq.2_Silent_p.Q248Q|NARFL_uc002cjs.2_Silent_p.Q132Q	NM_022493	NP_071938	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	350					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding				0		Hepatocellular(780;0.0218)				GTGTCACCTCCTGGAAGTCTT	0.627000												
KIF2B	84643	broad.mit.edu	37	17	51900853	51900853	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr17:51900853C>G	uc002iua.2	+	1	615	c.459C>G	c.(457-459)ATC>ATG	p.I153M	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	153	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TCTGGGAAATCCAGAAACTGC	0.557000												
SLC25A10	1468	broad.mit.edu	37	17	79686863	79686863	+	Silent	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr17:79686863C>T	uc002kbi.2	+	10	794	c.708C>T	c.(706-708)GGC>GGT	p.G236G	SLC25A10_uc010wut.1_Silent_p.G391G|SLC25A10_uc010dif.2_Silent_p.G245G|SLC25A10_uc010wuu.1_Silent_p.G190G	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	236	Solcar 3.				gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	TTCTGCAGGGCGTTTTCCACT	0.617000												
RIT2	6014	broad.mit.edu	37	18	40503659	40503659	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr18:40503659T>A	uc002lav.2	-	4	477	c.304A>T	c.(304-306)ACT>TCT	p.T102S	RIT2_uc010dnf.2_Missense_Mutation_p.T102S	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	102					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						TGACGGTCAGTGACGGAGTAG	0.463000												
SMAD4	4089	broad.mit.edu	37	18	48591925	48591925	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr18:48591925G>A	uc010xdp.1	+	9	1626	c.1088G>A	c.(1087-1089)TGT>TAT	p.C363Y	SMAD4_uc002lfb.3_Missense_Mutation_p.C208Y	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	363	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(2)|p.C363R(1)|p.C363S(1)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		GATCGCTTTTGTTTGGGTCAA	0.418000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia			
ZNF607	84775	broad.mit.edu	37	19	38190612	38190612	+	Silent	SNP	T	T	C			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr19:38190612T>C	uc002ohc.1	-	5	1016	c.420A>G	c.(418-420)GAA>GAG	p.E140E	ZNF607_uc002ohb.1_Silent_p.E139E	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			ATTGATCAGGTTCCTCACTAG	0.363000												
RYR1	6261	broad.mit.edu	37	19	39016073	39016073	+	Silent	SNP	C	C	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr19:39016073C>G	uc002oit.2	+	71	10687	c.10557C>G	c.(10555-10557)CCC>CCG	p.P3519P	RYR1_uc002oiu.2_Silent_p.P3514P|RYR1_uc002oiv.1_Silent_p.P434P|RYR1_uc010xuf.1_Silent_p.P439P	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3519					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGATGCTGCCCATCGGCCTGA	0.637000												
FCGBP	8857	broad.mit.edu	37	19	40389651	40389651	+	Splice_Site	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr19:40389651C>T	uc002omp.3	-	18	8538	c.8530_splice	c.e18+1	p.D2844_splice		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor							extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			cagcccagcACCTTTGTTGAC	0.542000												
KLC3	147700	broad.mit.edu	37	19	45854575	45854575	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr19:45854575G>A	uc002pbf.1	+	13	1590	c.1475G>A	c.(1474-1476)CGG>CAG	p.R492Q	KLC3_uc010ejy.1_Missense_Mutation_p.R491Q|KLC3_uc002pbg.1_Missense_Mutation_p.R506Q	NM_177417	NP_803136	Q6P597	KLC3_HUMAN	kinesin light chain 3	492						cytoplasm|kinesin complex|microtubule	microtubule motor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		AAGGCCCCTCGGACCCTCAGC	0.642000												
LILRA2	11027	broad.mit.edu	37	19	55086394	55086394	+	Silent	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr19:55086394C>T	uc002qgg.3	+	4	638	c.549C>T	c.(547-549)GGC>GGT	p.G183G	LILRA2_uc010ern.2_Silent_p.G183G|LILRA2_uc002qgf.2_Silent_p.G183G|LILRA2_uc010yfe.1_Silent_p.G183G|LILRA2_uc010yff.1_Silent_p.G171G|LILRA2_uc010ero.2_Silent_p.G171G|LILRA2_uc010yfg.1_Silent_p.G183G	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	183	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TCTCCGTGGGCCCCGTGAGCC	0.577000												
PTPRH	5794	broad.mit.edu	37	19	55703088	55703088	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr19:55703088A>G	uc002qjq.2	-	11	2352	c.2279T>C	c.(2278-2280)GTG>GCG	p.V760A	PTPRH_uc010esv.2_Missense_Mutation_p.V582A|uc002qjr.2_Missense_Mutation_p.T58A	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	760	Helical; (Potential).				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GAGGATGCCCACAAAGGCTCC	0.617000												
ZNF606	80095	broad.mit.edu	37	19	58489997	58489997	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr19:58489997T>C	uc002qqw.2	-	7	2669	c.2051A>G	c.(2050-2052)CAG>CGG	p.Q684R	ZNF606_uc010yhp.1_Missense_Mutation_p.Q594R	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	684	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TCTTTCACACTGATTACATTT	0.413000												
LRP2	4036	broad.mit.edu	37	2	170033000	170033000	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr2:170033000G>A	uc002ues.2	-	54	10705	c.10492C>T	c.(10492-10494)CGC>TGC	p.R3498C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3498	Extracellular (Potential).|EGF-like 13.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TGAAGGGTGCGGAAGTCATCT	0.532000												
KCNG1	3755	broad.mit.edu	37	20	49626831	49626831	+	Silent	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr20:49626831C>T	uc002xwa.3	-	2	340	c.45G>A	c.(43-45)GCG>GCA	p.A15A	KCNG1_uc002xwb.2_Silent_p.A15A	NM_002237	NP_002228	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G,	15	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|central_nervous_system(1)	2						TGCAGCTCAGCGCGCTGTAGT	0.667000												
YWHAH	7533	broad.mit.edu	37	22	32352435	32352435	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr22:32352435T>G	uc003alz.2	+	2	638	c.397T>G	c.(397-399)TAC>GAC	p.Y133D	YWHAH_uc010gwl.2_Missense_Mutation_p.Y63D|YWHAH_uc003ama.2_Missense_Mutation_p.Y63D|YWHAH_uc010gwm.2_Missense_Mutation_p.Y120D	NM_003405	NP_003396	Q04917	1433F_HUMAN	tyrosine 3-monooxygenase/tryptophan	133					glucocorticoid catabolic process|glucocorticoid receptor signaling pathway|intracellular protein transport|negative regulation of dendrite morphogenesis|positive regulation of transcription, DNA-dependent|regulation of synaptic plasticity	cytoplasm	enzyme binding|glucocorticoid receptor binding|insulin-like growth factor receptor binding|protein domain specific binding			central_nervous_system(1)	1						TTACTACCGCTACTTAGCAGA	0.453000												
SGSM3	27352	broad.mit.edu	37	22	40800320	40800320	+	Missense_Mutation	SNP	G	G	A	rs73420601	by1000genomes	TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr22:40800320G>A	uc003ayu.1	+	5	436	c.227G>A	c.(226-228)CGG>CAG	p.R76Q	SGSM3_uc010gyc.1_Missense_Mutation_p.R76Q|SGSM3_uc011aos.1_Missense_Mutation_p.R9Q|SGSM3_uc011aot.1_Missense_Mutation_p.R13Q|SGSM3_uc010gyd.1_Missense_Mutation_p.R76Q	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	76					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						CAGAGGCTGCGGTGGCAGGCC	0.597000												
ACO2	50	broad.mit.edu	37	22	41924552	41924552	+	Missense_Mutation	SNP	G	G	A	rs115203053	byFrequency	TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr22:41924552G>A	uc003bac.2	+	18	2300	c.2278G>A	c.(2278-2280)GAG>AAG	p.E760K	ACO2_uc003bad.2_Missense_Mutation_p.E785K|POLR3H_uc003bae.2_RNA|POLR3H_uc003baf.2_3'UTR|POLR3H_uc003bag.2_3'UTR|POLR3H_uc003bai.2_3'UTR	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	760					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						CACCTTCAACGAGACGCAGAT	0.607000												
ITPR1	3708	broad.mit.edu	37	3	4699844	4699844	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr3:4699844C>T	uc003bqa.2	+	13	1381	c.1033C>T	c.(1033-1035)CGG>TGG	p.R345W	ITPR1_uc010hca.1_Missense_Mutation_p.R330W|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.R330W	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	345	Cytoplasmic (Potential).|MIR 4.				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AAGTAGGTTGCGGAATGCCCA	0.498000												
RHOA	387	broad.mit.edu	37	3	49412907	49412907	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr3:49412907A>C	uc003cwu.2	-	2	392	c.116T>G	c.(115-117)TTT>TGT	p.F39C	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	39	Effector region (Potential).				axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ATAGTTCTCAAACACTGTGGG	0.433000												
P2RY14	9934	broad.mit.edu	37	3	150931958	150931958	+	Silent	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr3:150931958G>A	uc003eyr.1	-	3	625	c.147C>T	c.(145-147)TAC>TAT	p.Y49Y	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Silent_p.Y49Y	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	49	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGCTGGGCACGTAAAAGAATA	0.428000												
ANTXR2	118429	broad.mit.edu	37	4	80975471	80975471	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr4:80975471G>C	uc003hlz.3	-	7	1354	c.591C>G	c.(589-591)TTC>TTG	p.F197L	ANTXR2_uc003hly.3_Missense_Mutation_p.F197L|ANTXR2_uc003hlx.1_RNA|ANTXR2_uc010ijn.2_Missense_Mutation_p.F197L	NM_001145794	NP_001139266	P58335	ANTR2_HUMAN	anthrax toxin receptor 2 isoform 2	197	Extracellular (Potential).|VWFA.					endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			ovary(1)	1						CTTTGACAGGGAAAACTTGCT	0.368000									Juvenile_Hyaline_Fibromatosis			
KIAA1109	84162	broad.mit.edu	37	4	123265668	123265668	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr4:123265668G>T	uc003ieh.2	+	72	12730	c.12685G>T	c.(12685-12687)GTA>TTA	p.V4229L	KIAA1109_uc003iem.2_Missense_Mutation_p.V585L|KIAA1109_uc003ien.2_Missense_Mutation_p.V163L	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4229					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AAGTCAGTCTGTAAGCAAGTC	0.323000												
GPR98	84059	broad.mit.edu	37	5	90052364	90052364	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr5:90052364C>T	uc003kju.2	+	56	11770	c.11674C>T	c.(11674-11676)CGG>TGG	p.R3892W	GPR98_uc003kjt.2_Missense_Mutation_p.R1598W|GPR98_uc003kjv.2_Missense_Mutation_p.R1492W	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3892	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GCCAAGTGTGCGGAGGCCCGG	0.438000												
FEM1C	56929	broad.mit.edu	37	5	114878880	114878880	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr5:114878880T>C	uc003krb.1	-	2	873	c.311A>G	c.(310-312)AAT>AGT	p.N104S		NM_020177	NP_064562	Q96JP0	FEM1C_HUMAN	feminization 1 homolog a	104	ANK 3.					cytoplasm				breast(2)|ovary(1)	3		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		TGCTCCATGATTTAACAAGGA	0.493000												
KIF3A	11127	broad.mit.edu	37	5	132056301	132056301	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr5:132056301G>A	uc003kxo.2	-	5	770	c.616C>T	c.(616-618)CGT>TGT	p.R206C	KIF3A_uc003kxn.2_Missense_Mutation_p.R165C|KIF3A_uc011cxf.1_Missense_Mutation_p.R206C|KIF3A_uc003kxp.2_Missense_Mutation_p.R206C	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	206	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTATACTTACGATTTTTGTGG	0.363000												
GNB2L1	10399	broad.mit.edu	37	5	180665164	180665164	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr5:180665164C>T	uc003mni.1	-	6	818	c.712G>A	c.(712-714)GCC>ACC	p.A238T	GNB2L1_uc003mnh.1_Missense_Mutation_p.A197T|GNB2L1_uc003mnk.1_Missense_Mutation_p.A160T|GNB2L1_uc003mnj.1_Missense_Mutation_p.A192T|GNB2L1_uc003mnl.1_Missense_Mutation_p.A22T	NM_006098	NP_006089	P63244	GBLP_HUMAN	guanine nucleotide binding protein (G protein),	238	WD 6.				apoptosis|cell cycle|gastrulation|interspecies interaction between organisms|negative regulation of cell growth|negative regulation of phagocytosis|negative regulation of translation|negative regulation of Wnt receptor signaling pathway|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of gastrulation|positive regulation of GTPase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein homooligomerization|positive regulation of protein phosphorylation|regulation of cell cycle|regulation of cell division|regulation of establishment of cell polarity|regulation of protein localization|rhythmic process	cytoskeleton|dendrite|midbody|nucleus|perikaryon|perinuclear region of cytoplasm|phagocytic cup|small ribosomal subunit	ion channel inhibitor activity|protein kinase C binding|protein phosphatase binding|protein tyrosine kinase inhibitor activity|receptor tyrosine kinase binding|SH2 domain binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.101)|all cancers(165;0.11)		AAGCACAGGGCGTTGATGATG	0.542000												
MDC1	9656	broad.mit.edu	37	6	30680092	30680092	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr6:30680092C>T	uc003nrg.3	-	5	2067	c.1627G>A	c.(1627-1629)GTG>ATG	p.V543M	MDC1_uc003nrf.3_Missense_Mutation_p.V197M|MDC1_uc011dmp.1_Missense_Mutation_p.V415M|MDC1_uc003nrh.1_Missense_Mutation_p.V415M|MDC1_uc003nri.2_Missense_Mutation_p.V543M	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	543	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TCCACAGACACCTGATGCTTC	0.522000								Other_conserved_DNA_damage_response_genes				
MAGI2	9863	broad.mit.edu	37	7	79082564	79082564	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr7:79082564C>T	uc003ugx.2	-	1	327	c.73G>A	c.(73-75)GAG>AAG	p.E25K	MAGI2_uc003ugy.2_Missense_Mutation_p.E25K|uc010lea.1_5'Flank	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	25	PDZ 1.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGCTGGCCCTCCGGGTTCCTG	0.587000												
PON1	5444	broad.mit.edu	37	7	94928393	94928393	+	Silent	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr7:94928393G>A	uc003uns.2	-	9	1028	c.931C>T	c.(931-933)CTA>TTA	p.L311L	PON1_uc011kih.1_Silent_p.L311L	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	311					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TCTTCTGTTAGAATGTTCTGG	0.398000												
ADAM28	10863	broad.mit.edu	37	8	24207414	24207414	+	Silent	SNP	G	G	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr8:24207414G>A	uc003xdy.2	+	19	2111	c.2028G>A	c.(2026-2028)GCG>GCA	p.A676A	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Silent_p.A363A	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	676	Helical; (Potential).				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TCCCAATGGCGGTCATTTTTG	0.502000												
CSMD3	114788	broad.mit.edu	37	8	113243795	113243795	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr8:113243795G>T	uc003ynu.2	-	69	10966	c.10807C>A	c.(10807-10809)CAA>AAA	p.Q3603K	CSMD3_uc003yns.2_Missense_Mutation_p.Q2805K|CSMD3_uc003ynt.2_Missense_Mutation_p.Q3563K|CSMD3_uc011lhx.1_Missense_Mutation_p.Q3434K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3603	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGCCAAATTGTCCATAATCT	0.328000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
KIAA1797	54914	broad.mit.edu	37	9	20907176	20907176	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr9:20907176C>T	uc003zog.1	+	24	3016	c.2653C>T	c.(2653-2655)CGT>TGT	p.R885C	KIAA1797_uc003zoh.1_Missense_Mutation_p.R321C	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	885						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		aGAGTGGCACCGTGCAATTTT	0.269000												
IFNA10	3446	broad.mit.edu	37	9	21206898	21206898	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr9:21206898C>G	uc003zoq.1	-	1	245	c.199G>C	c.(199-201)GAT>CAT	p.D67H	IFNA14_uc003zoo.1_Intron	NM_002171	NP_002162	P01566	IFN10_HUMAN	interferon, alpha 10 precursor	67					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		TGGTTGCCATCAAACTCCTCC	0.502000												
GOLM1	51280	broad.mit.edu	37	9	88667485	88667485	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr9:88667485T>A	uc004aol.2	-	4	529	c.331A>T	c.(331-333)ACC>TCC	p.T111S	GOLM1_uc010mqd.1_Intron|GOLM1_uc004aom.2_Missense_Mutation_p.T111S	NM_016548	NP_057632	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	111	Potential.|Lumenal (Potential).					Golgi apparatus|integral to plasma membrane					0						TCACCTGTGGTGATGTTATTC	0.512000												
GOLM1	51280	broad.mit.edu	37	9	88667488	88667488	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr9:88667488T>G	uc004aol.2	-	4	526	c.328A>C	c.(328-330)ATC>CTC	p.I110L	GOLM1_uc010mqd.1_Intron|GOLM1_uc004aom.2_Missense_Mutation_p.I110L	NM_016548	NP_057632	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	110	Potential.|Lumenal (Potential).					Golgi apparatus|integral to plasma membrane					0						CCTGTGGTGATGTTATTCACC	0.522000												
OR1L3	26735	broad.mit.edu	37	9	125437839	125437839	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr9:125437839T>C	uc011lzb.1	+	1	431	c.431T>C	c.(430-432)CTA>CCA	p.L144P		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TGTGTGTTGCTACTAGCATTC	0.448000												
MRPL41	64975	broad.mit.edu	37	9	140446797	140446797	+	Silent	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr9:140446797C>T	uc004cnh.3	+	2	394	c.264C>T	c.(262-264)GCC>GCT	p.A88A	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	88					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		CCCTGACGGCCGCGCAGCTCT	0.622000												
CACNA1B	774	broad.mit.edu	37	9	140850187	140850187	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr9:140850187C>T	uc004cog.2	+	8	1253	c.1108C>T	c.(1108-1110)CGC>TGC	p.R370C	CACNA1B_uc011mfd.1_5'Flank	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	370	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GGAGAACCGCCGCGCCTTCCT	0.642000												
ARID1A	8289	broad.mit.edu	37	1	27100199	27100200	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr1:27100199_27100200insG	uc001bmv.1	+	16	4368_4369	c.3995_3996insG	c.(3994-3996)CAGfs	p.Q1332fs	ARID1A_uc001bmt.1_Frame_Shift_Ins_p.Q1331fs|ARID1A_uc001bmu.1_Frame_Shift_Ins_p.Q1332fs|ARID1A_uc001bmw.1_Frame_Shift_Ins_p.Q949fs|ARID1A_uc001bmx.1_Frame_Shift_Ins_p.Q178fs|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1332	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Q1332*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		cagcagcagcagcagcaACGGT	0.490			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
ALKBH6	84964	broad.mit.edu	37	19	36500365	36500365	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr19:36500365delG	uc002oct.2	-	7	644	c.544delC	c.(544-546)CACfs	p.H182fs	C19orf46_uc002ocr.1_5'Flank|C19orf46_uc002ocs.1_5'Flank|C19orf46_uc002ocq.1_5'Flank|C19orf46_uc010een.1_5'Flank|ALKBH6_uc002ocv.1_Frame_Shift_Del_p.H210fs|ALKBH6_uc002ocx.1_Frame_Shift_Del_p.H113fs|ALKBH6_uc002ocw.1_3'UTR|ALKBH6_uc010eeo.1_Frame_Shift_Del_p.H182fs	NM_032878	NP_116267	Q3KRA9	ALKB6_HUMAN	alkB, alkylation repair homolog 6 isoform 2	182	Fe2OG dioxygenase.	Iron; catalytic (By similarity).				cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_lung(56;1.35e-06)|Lung NSC(56;2.15e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCGATGCCGTGGAGAAGACGC	0.776												
ITGAV	3685	broad.mit.edu	37	2	187540409	187540409	+	Frame_Shift_Del	DEL	G	G	-	rs146319338	byFrequency	TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr2:187540409delG	uc002upq.2	+	27	3061	c.2785delG	c.(2785-2787)GTAfs	p.V929fs	ITGAV_uc010frs.2_Frame_Shift_Del_p.V893fs|ITGAV_uc010zfv.1_Frame_Shift_Del_p.V883fs	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	929	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		AATCTTGTACGTAAAGTCATT	0.398												
ARID1A	8289	broad.mit.edu	37	1	27100200	27100201	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-7722-01A-31D-2201-08	TCGA-BR-7722-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fa9cfba-0f49-47d0-ab54-9dd2144e0a73	1fd04123-dbaa-4c8c-9c89-b9cb1a30c14c	g.chr1:27100199_27100200A>AG	uc001bmv.1	+	15	4368_4369	c.3995_3996A>AG	c.(3994-3996)cagfs	p.Q1332fs	ARID1A_uc001bmt.1_Frame_Shift_Ins_p.Q1331fs|ARID1A_uc001bmu.1_Frame_Shift_Ins_p.Q1332fs|ARID1A_uc001bmw.1_Frame_Shift_Ins_p.Q949fs|ARID1A_uc001bmx.1_Frame_Shift_Ins_p.Q178fs|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 1, mRNA.	1332	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	SWI/SNF complex|nBAF complex|npBAF complex	DNA binding|protein binding	p.Q1332*(1)|p.Q1331*(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		cagcagcagcagcagcaACGGT	0.569			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""