Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CAMTA1	23261	broad.mit.edu	37	1	7737720	7737720	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:7737720G>A	uc001aoi.2	+	11	3048	c.2841G>A	c.(2839-2841)TCG>TCA	p.S947S	CAMTA1_uc010nzv.1_Silent_p.S34S|CAMTA1_uc001aok.3_5'Flank	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	947	IPT/TIG.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TCTCCAACTCGGTGGTGTTTG	0.552000												
ZMYM1	79830	broad.mit.edu	37	1	35570337	35570337	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:35570337T>G	uc001bym.2	+	7	922	c.774T>G	c.(772-774)TTT>TTG	p.F258L	ZMYM1_uc009vus.1_RNA|ZMYM1_uc001byn.2_Missense_Mutation_p.F258L|ZMYM1_uc010ohu.1_Missense_Mutation_p.F258L|ZMYM1_uc001byo.2_5'UTR|ZMYM1_uc009vut.2_Missense_Mutation_p.F183L	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	258						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTCATTACTTTAATAGTTCAA	0.378000												
CAP1	10487	broad.mit.edu	37	1	40535894	40535894	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:40535894A>T	uc001cfa.3	+	10	1286	c.1057A>T	c.(1057-1059)ATA>TTA	p.I353L	CAP1_uc001cey.3_Missense_Mutation_p.I353L|CAP1_uc001cez.3_Missense_Mutation_p.I353L|CAP1_uc009vvz.2_Missense_Mutation_p.I353L|CAP1_uc010oje.1_Missense_Mutation_p.I270L	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	353	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGTGGCTTACATATACAAGTG	0.458000												
INSL5	10022	broad.mit.edu	37	1	67266854	67266854	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:67266854G>C	uc001dcw.2	-	1	86	c.51C>G	c.(49-51)ATC>ATG	p.I17M		NM_005478	NP_005469	Q9Y5Q6	INSL5_HUMAN	insulin-like 5 precursor	17						extracellular region	hormone activity				0						GCACTTCTGAGATGGCAAATA	0.433000												
LRRC7	57554	broad.mit.edu	37	1	70555456	70555456	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:70555456G>A	uc001dep.2	+	23	4415	c.4385G>A	c.(4384-4386)AGT>AAT	p.S1462N	LRRC7_uc009wbg.2_Missense_Mutation_p.S746N|LRRC7_uc001deq.2_Missense_Mutation_p.S656N	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1462	PDZ.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTTAGTATCAGTGGTGGAATT	0.299000												
HFM1	164045	broad.mit.edu	37	1	91784848	91784848	+	Splice_Site	SNP	A	A	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:91784848A>G	uc001doa.3	-	24	2780	c.2680_splice	c.e24+1	p.W894_splice	HFM1_uc009wdb.2_Splice_Site|HFM1_uc010osu.1_Splice_Site_p.W573_splice|HFM1_uc001dob.3_Splice_Site_p.C126_splice|HFM1_uc010osv.1_Splice_Site_p.W578_splice	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CCTGTAACATACATCTTGTAA	0.333000												
TMEM56	148534	broad.mit.edu	37	1	95639441	95639441	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:95639441C>T	uc001drb.2	+	6	760	c.469C>T	c.(469-471)CAG>TAG	p.Q157*	RWDD3_uc001drd.3_Nonsense_Mutation_p.Q157*|uc001dre.1_Intron|TMEM56_uc001drc.2_Nonsense_Mutation_p.Q157*	NM_152487	NP_689700	Q96MV1	TMM56_HUMAN	transmembrane protein 56	157	TLC.					integral to membrane					0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		GTTTGTGAATCAGCGGTATGT	0.368000												
VAV3	10451	broad.mit.edu	37	1	108313276	108313276	+	Silent	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:108313276A>C	uc001dvk.1	-	6	684	c.630T>G	c.(628-630)ACT>ACG	p.T210T	VAV3_uc010ouw.1_Silent_p.T210T|VAV3_uc001dvl.1_Silent_p.T34T|VAV3_uc010oux.1_Silent_p.T210T	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	210	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TTGACTCCAAAGTTTCTGTAT	0.303000												
SLC6A17	388662	broad.mit.edu	37	1	110714822	110714822	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:110714822G>A	uc009wfq.2	+	3	888	c.427G>A	c.(427-429)GGC>AGC	p.G143S		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	143	Cytoplasmic (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GGGGGGCATCGGCTTCTCCAG	0.642000												
GJA8	2703	broad.mit.edu	37	1	147380926	147380926	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:147380926A>C	uc001epu.1	+	2	907	c.844A>C	c.(844-846)ACC>CCC	p.T282P		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	282	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					TTTCCCCTTGACCGAGGTTGG	0.547000												
MCL1	4170	broad.mit.edu	37	1	150550743	150550743	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:150550743A>C	uc001euz.2	-	2	1043	c.913T>G	c.(913-915)TGG>GGG	p.W305G	MCL1_uc010pch.1_Missense_Mutation_p.W195G|MCL1_uc001eva.2_Intron	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	305	BH2.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TTAACTAGCCAGTCCCGTTTT	0.433000												
POGZ	23126	broad.mit.edu	37	1	151378488	151378488	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:151378488C>T	uc001eyd.1	-	19	3329	c.3023G>A	c.(3022-3024)CGA>CAA	p.R1008Q	POGZ_uc001eye.1_Missense_Mutation_p.R955Q|POGZ_uc010pdb.1_Missense_Mutation_p.R999Q|POGZ_uc001eyf.1_Missense_Mutation_p.R964Q|POGZ_uc010pdc.1_Missense_Mutation_p.R946Q|POGZ_uc009wmv.1_Missense_Mutation_p.R913Q|POGZ_uc010pdd.1_Missense_Mutation_p.R499Q	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	1008					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTGGAAACGTCGAAGCCAACG	0.522000												
FCGR2A	2212	broad.mit.edu	37	1	161480730	161480730	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:161480730G>A	uc001gan.2	+	5	779	c.726G>A	c.(724-726)AGG>AGA	p.R242R	FCGR2A_uc001gam.2_Silent_p.R241R|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	242	Cytoplasmic (Potential).					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCTACTGCAGGAAAAAGCGGA	0.522000												
TNN	63923	broad.mit.edu	37	1	175067563	175067563	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:175067563G>A	uc001gkl.1	+	9	2064	c.1951G>A	c.(1951-1953)GTG>ATG	p.V651M	TNN_uc010pmx.1_Missense_Mutation_p.V562M	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	651	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGACAAGTACGTGGTGCGCTA	0.597000												
HMCN1	83872	broad.mit.edu	37	1	186056429	186056429	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:186056429G>T	uc001grq.1	+	59	9356	c.9127G>T	c.(9127-9129)GAA>TAA	p.E3043*		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3043	Ig-like C2-type 28.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCAAGCTGGCGAAAGCAAGAA	0.353000												
CABC1	56997	broad.mit.edu	37	1	227165157	227165157	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:227165157C>T	uc001hqm.1	+	10	4082	c.663C>T	c.(661-663)GCC>GCT	p.A221A	CABC1_uc001hqn.1_Silent_p.A221A|CABC1_uc009xeq.1_Silent_p.A169A|CABC1_uc010pvq.1_5'UTR|CABC1_uc010pvr.1_5'UTR|CABC1_uc001hqo.1_5'UTR	NM_020247	NP_064632	Q8NI60	ADCK3_HUMAN	chaperone, ABC1 activity of bc1 complex like	221					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity				0		Prostate(94;0.0771)				CAGGTCTGGCCGTGGGCCTGG	0.716000												
WNT9A	7483	broad.mit.edu	37	1	228111927	228111927	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:228111927C>A	uc001hri.2	-	3	615	c.527G>T	c.(526-528)AGC>ATC	p.S176I		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	176					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				GACGAACTTGCTGCTGTACTT	0.592000												
CAMK1D	57118	broad.mit.edu	37	10	12803037	12803037	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:12803037C>T	uc001ilo.2	+	4	625	c.390C>T	c.(388-390)GAC>GAT	p.D130D	CAMK1D_uc001iln.2_Silent_p.D130D	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	130	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		AAGTCTTGGACGCCGTGTACT	0.557000												
CUBN	8029	broad.mit.edu	37	10	17126401	17126401	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:17126401A>C	uc001ioo.2	-	17	2222	c.2170T>G	c.(2170-2172)TTG>GTG	p.L724V		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	724	CUB 3.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGCCCAGACAACTCAGGCAAG	0.517000												
MYO3A	53904	broad.mit.edu	37	10	26463195	26463195	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:26463195G>A	uc001isn.2	+	30	4362	c.4002G>A	c.(4000-4002)AGG>AGA	p.R1334R	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1334					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						TCAAAGAGAGGCAAGTTGAAC	0.502000												
KIAA1462	57608	broad.mit.edu	37	10	30318057	30318057	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:30318057G>A	uc001iux.2	-	2	1079	c.1020C>T	c.(1018-1020)TAC>TAT	p.Y340Y	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.Y202Y|KIAA1462_uc009xle.1_Silent_p.Y340Y	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	340	Pro-rich.									ovary(4)	4						GCGGAGGCACGTACACTGGAG	0.587000												
SAMD8	142891	broad.mit.edu	37	10	76935972	76935972	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:76935972A>T	uc001jwx.1	+	5	1044	c.941A>T	c.(940-942)GAA>GTA	p.E314V	SAMD8_uc001jwy.1_Missense_Mutation_p.E314V	NM_144660	NP_653261	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	314					sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					TTTGTCACCGAATGTAAGTAT	0.453000												
TLL2	7093	broad.mit.edu	37	10	98192670	98192670	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:98192670G>A	uc001kml.1	-	4	640	c.414C>T	c.(412-414)GCC>GCT	p.A138A	TLL2_uc009xvf.1_Intron	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	138					cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TCTTGGCTGCGGCATGCAAGG	0.552000												
RRP12	23223	broad.mit.edu	37	10	99116858	99116858	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:99116858C>T	uc001knf.2	-	34	4026	c.3887G>A	c.(3886-3888)CGA>CAA	p.R1296Q	RRP12_uc001kne.2_Missense_Mutation_p.R311Q|RRP12_uc009xvl.2_Missense_Mutation_p.R413Q|RRP12_uc009xvm.2_Missense_Mutation_p.R1014Q|RRP12_uc010qou.1_Missense_Mutation_p.R1235Q|RRP12_uc009xvn.2_Missense_Mutation_p.R1196Q	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	1296						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GCCTCAGGGTCGACGATCCTT	0.622000												
RRP12	23223	broad.mit.edu	37	10	99133605	99133605	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:99133605G>A	uc001knf.2	-	16	1984	c.1845C>T	c.(1843-1845)TAC>TAT	p.Y615Y	RRP12_uc009xvl.2_5'Flank|RRP12_uc009xvm.2_Silent_p.Y333Y|RRP12_uc010qou.1_Silent_p.Y554Y|RRP12_uc009xvn.2_Silent_p.Y515Y	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	615						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GGAGTGTGTCGTAGATCTTAG	0.607000												
PDCD11	22984	broad.mit.edu	37	10	105172893	105172893	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:105172893C>T	uc001kwy.1	+	9	1086	c.999C>T	c.(997-999)TGC>TGT	p.C333C		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	333	S1 motif 3.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GCATCCTTTGCGTCCATCCTC	0.597000												
GPR26	2849	broad.mit.edu	37	10	125426323	125426323	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:125426323G>A	uc001lhh.2	+	1	453	c.400G>A	c.(400-402)GCG>ACG	p.A134T		NM_153442	NP_703143	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	134	Helical; Name=4; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				GTGGCTGCACGCGCTCACCTT	0.716000												
LRRC27	80313	broad.mit.edu	37	10	134165209	134165209	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:134165209C>T	uc010quw.1	+	7	1220	c.1025C>T	c.(1024-1026)GCG>GTG	p.A342V	LRRC27_uc001llf.2_Missense_Mutation_p.R374C|LRRC27_uc010quv.1_Missense_Mutation_p.A342V|LRRC27_uc001llg.2_RNA|LRRC27_uc001lli.2_Missense_Mutation_p.A342V|LRRC27_uc001llj.2_Missense_Mutation_p.A280V|LRRC27_uc001llk.3_Missense_Mutation_p.A215V	NM_030626	NP_085129	Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27 isoform a	342	Potential.									ovary(1)	1		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		CGAGCGGCGGCGCTCCGAGAG	0.622000												
PAOX	196743	broad.mit.edu	37	10	135204907	135204907	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr10:135204907G>A	uc001lmv.2	+	7	1564	c.1484G>A	c.(1483-1485)CGC>CAC	p.R495H	PAOX_uc001lmw.2_RNA|PAOX_uc001lmx.2_Silent_p.P442P|PAOX_uc001lmy.2_3'UTR|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_RNA|PAOX_uc001lnc.2_RNA|MTG1_uc001lnd.2_5'Flank	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	633					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		GAGGCCGACCGCCTCCTCAGT	0.662000												
OR51D1	390038	broad.mit.edu	37	11	4661487	4661487	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:4661487A>T	uc010qyk.1	+	1	467	c.467A>T	c.(466-468)AAG>ATG	p.K156M		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTGTGGCCAAGATTGGACTA	0.537000												
OR52J3	119679	broad.mit.edu	37	11	5068233	5068233	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:5068233C>T	uc010qyv.1	+	1	478	c.478C>T	c.(478-480)CCC>TCC	p.P160S		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTTACACTTCCCATGGTCTA	0.468000												
OR52E4	390081	broad.mit.edu	37	11	5905690	5905690	+	Silent	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:5905690T>C	uc010qzs.1	+	1	168	c.168T>C	c.(166-168)AGT>AGC	p.S56S	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	56	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGAACATAGTCTACACCAGC	0.418000												
CNGA4	1262	broad.mit.edu	37	11	6265440	6265440	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:6265440A>C	uc001mco.2	+	6	1636	c.1529A>C	c.(1528-1530)AAG>ACG	p.K510T	CNGA4_uc010raa.1_3'UTR|CNGA4_uc001mcn.2_3'UTR	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	510	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTACAGACCAAGTTTGCTCGC	0.587000												
NELL1	4745	broad.mit.edu	37	11	21594756	21594756	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:21594756T>G	uc001mqe.2	+	19	2336	c.2183T>G	c.(2182-2184)CTC>CGC	p.L728R	NELL1_uc001mqf.2_Missense_Mutation_p.L681R|NELL1_uc009yid.2_Missense_Mutation_p.L756R|NELL1_uc010rdo.1_Missense_Mutation_p.L671R|NELL1_uc010rdp.1_Missense_Mutation_p.L441R|NELL1_uc001mqh.2_Missense_Mutation_p.L273R	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	728	VWFC 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TGCTGGCCACTCACTTGCCCC	0.443000												
OR8H3	390152	broad.mit.edu	37	11	55890577	55890577	+	Silent	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:55890577T>C	uc001nii.1	+	1	729	c.729T>C	c.(727-729)TCT>TCC	p.S243S		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					CTTGCGTCTCTCATCTCTTGG	0.403000												
OR10W1	81341	broad.mit.edu	37	11	58034972	58034972	+	Missense_Mutation	SNP	G	G	A	rs144496337	byFrequency	TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:58034972G>A	uc001nmq.1	-	1	761	c.359C>T	c.(358-360)CCG>CTG	p.P120L		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GTACTGCAACGGGTGGCAAAT	0.537000												
ORAOV1	220064	broad.mit.edu	37	11	69488060	69488060	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:69488060T>C	uc001opc.2	-	2	238	c.80A>G	c.(79-81)TAT>TGT	p.Y27C	ORAOV1_uc010rqi.1_Missense_Mutation_p.Y27C|ORAOV1_uc009ysm.2_RNA|ORAOV1_uc001opd.2_Intron|ORAOV1_uc001ope.1_Missense_Mutation_p.Y27C	NM_153451	NP_703152	Q8WV07	ORAV1_HUMAN	oral cancer overexpressed 1	27											0	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			GCCTTCTTCATAGCCTTCCCG	0.493000												
BIRC2	329	broad.mit.edu	37	11	102221160	102221160	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:102221160A>G	uc001pgy.2	+	2	1974	c.575A>G	c.(574-576)CAT>CGT	p.H192R	BIRC2_uc010ruq.1_Missense_Mutation_p.H143R|BIRC2_uc010rur.1_Missense_Mutation_p.H192R	NM_001166	NP_001157	Q13490	BIRC2_HUMAN	baculoviral IAP repeat-containing protein 2	192	BIR 2.				cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		CTTACCTACCATATGTGGCCA	0.428000												
GRIA4	2893	broad.mit.edu	37	11	105795340	105795340	+	Silent	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:105795340A>C	uc001pix.2	+	12	2138	c.1692A>C	c.(1690-1692)CTA>CTC	p.L564L	GRIA4_uc001piw.2_Silent_p.L564L	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	564	Helical; (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TCTTATTCCTAGTTAGTAGAT	0.468000												
OR8D2	283160	broad.mit.edu	37	11	124189172	124189172	+	Silent	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr11:124189172T>G	uc010sah.1	-	1	922	c.922A>C	c.(922-924)AGG>CGG	p.R308R		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		GATGACTGCCTTCCCCTAGTC	0.398000												
CLEC2D	29121	broad.mit.edu	37	12	9847417	9847417	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr12:9847417A>G	uc001qwg.1	+	5	545	c.523A>G	c.(523-525)AGG>GGG	p.R175G	CLEC2D_uc001qwf.1_3'UTR|CLEC2D_uc009zgs.1_RNA|CLEC2D_uc001qwh.1_RNA|CLEC2D_uc009zgt.1_RNA|CLEC2D_uc009zgu.1_3'UTR	NM_013269	NP_037401	Q9UHP7	CLC2D_HUMAN	osteoclast inhibitory lectin isoform 1	175	Extracellular (Potential).|C-type lectin.				cell surface receptor linked signaling pathway	cell surface|endoplasmic reticulum|integral to plasma membrane|membrane fraction	sugar binding|transmembrane receptor activity				0						CAGTAGTGCCAGGCACTACAC	0.433000												
KLRD1	3824	broad.mit.edu	37	12	10462015	10462015	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr12:10462015T>G	uc001qxw.3	+	3	233	c.36T>G	c.(34-36)ATT>ATG	p.I12M	KLRD1_uc001qxx.3_Missense_Mutation_p.I12M|KLRD1_uc001qxy.3_Intron|KLRD1_uc009zhh.2_Missense_Mutation_p.I12M|KLRD1_uc009zhi.2_Missense_Mutation_p.I12M|KLRD1_uc001qxz.3_Missense_Mutation_p.I12M	NM_001114396	NP_001107868	Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D,	12	Helical; Signal-anchor for type II membrane protein; (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						GGAGGTTAATTTCTGGGACCT	0.363000												
PLCZ1	89869	broad.mit.edu	37	12	18841074	18841074	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr12:18841074C>A	uc010sid.1	-	13	1731	c.1540G>T	c.(1540-1542)GGT>TGT	p.G514C	PLCZ1_uc001rdv.3_Missense_Mutation_p.G410C|PLCZ1_uc001rdw.3_Missense_Mutation_p.G255C|PLCZ1_uc001rdu.1_Missense_Mutation_p.G296C|PLCZ1_uc009zil.1_RNA	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	514	C2.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					TTTGGAACACCAAAAACTTCT	0.333000												
CEP290	80184	broad.mit.edu	37	12	88530428	88530428	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr12:88530428T>C	uc001tar.2	-	6	777	c.433A>G	c.(433-435)AAT>GAT	p.N145D	CEP290_uc009zsl.1_RNA	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	145	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						ACTTGCTCATTAACTTTCTTC	0.294000												
P2RX2	22953	broad.mit.edu	37	12	133196330	133196330	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr12:133196330C>A	uc001ukj.1	+	3	375	c.375C>A	c.(373-375)TGC>TGA	p.C125*	P2RX2_uc001uki.1_Nonsense_Mutation_p.C125*|P2RX2_uc001ukk.1_Nonsense_Mutation_p.C125*|P2RX2_uc001ukl.1_Intron|P2RX2_uc001ukm.1_Intron|P2RX2_uc001ukn.1_Intron|P2RX2_uc009zyt.1_Nonsense_Mutation_p.C125*|P2RX2_uc001uko.1_Intron	NM_170682	NP_733782	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X2 isoform A	125	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		AGGGAACCTGCCCCGAGGTGA	0.721000												
FREM2	341640	broad.mit.edu	37	13	39262883	39262883	+	Silent	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr13:39262883T>C	uc001uwv.2	+	1	1711	c.1402T>C	c.(1402-1404)TTG>CTG	p.L468L		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	468	Extracellular (Potential).|CSPG 2.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCCGCAAAACTTGGTCATCAG	0.587000												
FREM2	341640	broad.mit.edu	37	13	39435669	39435669	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr13:39435669A>C	uc001uwv.2	+	15	7930	c.7621A>C	c.(7621-7623)AAG>CAG	p.K2541Q	FREM2_uc001uww.2_Missense_Mutation_p.K627Q	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2541	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AAACCTTATCAAGCTCACTGT	0.473000												
PCDH17	27253	broad.mit.edu	37	13	58208116	58208116	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr13:58208116T>C	uc001vhq.1	+	1	2328	c.1436T>C	c.(1435-1437)CTT>CCT	p.L479P	PCDH17_uc010aec.1_Missense_Mutation_p.L479P	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	479	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CTCTACGTGCTTCAGGTGCAC	0.597000												
CHD8	57680	broad.mit.edu	37	14	21861850	21861850	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr14:21861850C>T	uc001was.1	-	32	5361	c.5267G>A	c.(5266-5268)CGA>CAA	p.R1756Q	CHD8_uc001war.1_Missense_Mutation_p.R1652Q|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2035					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TGGGGTTGGTCGGCTCCTGGC	0.547000												
POMT2	29954	broad.mit.edu	37	14	77751348	77751348	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr14:77751348G>A	uc001xti.2	-	14	1722	c.1521C>T	c.(1519-1521)TAC>TAT	p.Y507Y	POMT2_uc001xth.1_Silent_p.Y205Y	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	507	MIR 3.				protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		TTTCTTTCAGGTATGGGGTGC	0.498000												
NDN	4692	broad.mit.edu	37	15	23932080	23932080	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr15:23932080C>T	uc001ywk.2	-	1	371	c.285G>A	c.(283-285)CCG>CCA	p.P95P		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	95					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CCAGCTGCGCCGGGGCTGGCG	0.677000									Prader-Willi_syndrome			
GRAMD2	196996	broad.mit.edu	37	15	72455726	72455726	+	Silent	SNP	C	C	T	rs139817220		TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr15:72455726C>T	uc002atq.2	-	10	861	c.837G>A	c.(835-837)CCG>CCA	p.P279P	GRAMD2_uc010bis.2_Silent_p.P279P|GRAMD2_uc010ukh.1_Silent_p.P73P	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	279						integral to membrane					0						GAGAGCAGTTCGGCATCTTCT	0.572000												
SEMA4B	10509	broad.mit.edu	37	15	90771576	90771576	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr15:90771576C>T	uc002boy.2	+	15	2498	c.2215C>T	c.(2215-2217)CGG>TGG	p.R739W	SEMA4B_uc002boz.2_Missense_Mutation_p.R739W|SEMA4B_uc010uqd.1_Missense_Mutation_p.R577W|SEMA4B_uc002bpa.2_Missense_Mutation_p.R577W|SEMA4B_uc010bnv.1_Intron	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			CTTGCTCTACCGGCACCGGAA	0.607000												
ZSCAN10	84891	broad.mit.edu	37	16	3139328	3139328	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr16:3139328C>T	uc002ctv.1	-	5	2030	c.1942G>A	c.(1942-1944)GCG>ACG	p.A648T	ZSCAN10_uc002cty.1_Missense_Mutation_p.A309T|ZSCAN10_uc002ctw.1_Missense_Mutation_p.A566T|ZSCAN10_uc002ctx.1_Missense_Mutation_p.A576T	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	648	C2H2-type 12.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CGCAGATGCGCGTTGCGCCGG	0.711000												
ZSCAN10	84891	broad.mit.edu	37	16	3140172	3140172	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr16:3140172C>G	uc002ctv.1	-	5	1186	c.1098G>C	c.(1096-1098)AAG>AAC	p.K366N	ZSCAN10_uc002cty.1_Missense_Mutation_p.K27N|ZSCAN10_uc002ctw.1_Missense_Mutation_p.K284N|ZSCAN10_uc002ctx.1_Missense_Mutation_p.K294N	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	366	C2H2-type 3.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TCAGCAGGTGCTTGCTCAGGT	0.697000												
CORO7	79585	broad.mit.edu	37	16	4411080	4411080	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr16:4411080G>A	uc002cwh.3	-	19	1901	c.1781C>T	c.(1780-1782)ACG>ATG	p.T594M	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.T594M|CORO7_uc002cwg.3_Missense_Mutation_p.T374M|CORO7_uc010uxh.1_Missense_Mutation_p.T576M|CORO7_uc010uxi.1_Missense_Mutation_p.T509M|CORO7_uc002cwi.1_Missense_Mutation_p.T374M|CORO7_uc010uxj.1_RNA	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	594	WD 6.					cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						GATCTTCTCCGTGTGGCCTGG	0.622000												
XPO6	23214	broad.mit.edu	37	16	28112970	28112970	+	Missense_Mutation	SNP	C	C	T	rs14672		TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr16:28112970C>T	uc002dpa.1	-	23	3586	c.3085G>A	c.(3085-3087)GTG>ATG	p.V1029M	XPO6_uc002dpb.1_Missense_Mutation_p.V1015M|XPO6_uc010vcp.1_Missense_Mutation_p.V1028M	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	1029					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						TGGAGCAGCACGTTCACAAAC	0.577000												
CDH8	1006	broad.mit.edu	37	16	61761004	61761004	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr16:61761004G>A	uc002eog.1	-	9	1782	c.1530C>T	c.(1528-1530)CCC>CCT	p.P510P	CDH8_uc002eoh.2_Silent_p.P279P	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	510	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTACTTGGCCGGGTTTTCCAT	0.368000												
CDH11	1009	broad.mit.edu	37	16	64981820	64981820	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr16:64981820G>A	uc002eoi.2	-	13	2511	c.2077C>T	c.(2077-2079)CGC>TGC	p.R693C	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Missense_Mutation_p.R567C	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	693	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ATGTCTTTGCGGGGGATAAAT	0.488000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)		
GAS8	2622	broad.mit.edu	37	16	90099328	90099328	+	Missense_Mutation	SNP	G	G	A	rs141287302		TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr16:90099328G>A	uc002fqi.1	+	4	613	c.491G>A	c.(490-492)CGG>CAG	p.R164Q	GAS8_uc010vps.1_Missense_Mutation_p.R139Q|GAS8_uc002fqh.2_Missense_Mutation_p.R81Q|GAS8_uc010vpt.1_Missense_Mutation_p.R164Q|GAS8_uc010vpu.1_Missense_Mutation_p.R81Q|GAS8_uc010vpv.1_Missense_Mutation_p.R135Q|GAS8_uc010cjc.1_Missense_Mutation_p.R81Q|GAS8_uc010vpw.1_Missense_Mutation_p.R81Q|GAS8_uc002fqj.1_5'UTR	NM_001481	NP_001472	O95995	GAS8_HUMAN	growth arrest-specific 8	164	Microtubule-binding.				negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		AAGAACCTGCGGCTGGTAGGT	0.448000												
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
TNFAIP1	7126	broad.mit.edu	37	17	26671447	26671447	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr17:26671447A>T	uc002hax.1	+	7	791	c.772A>T	c.(772-774)ACT>TCT	p.T258S	TNFAIP1_uc002hay.2_Missense_Mutation_p.T258S|TNFAIP1_uc010waf.1_Missense_Mutation_p.T154S	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	258					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		ACTCTATGAGACTCCCCGCGT	0.572000												
CNTNAP1	8506	broad.mit.edu	37	17	40837321	40837321	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr17:40837321G>A	uc002iay.2	+	5	814	c.598G>A	c.(598-600)GCC>ACC	p.A200T	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	200	Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GGACGTGTTCGCCTTCAGCTT	0.642000												
TMC8	147138	broad.mit.edu	37	17	76127802	76127802	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr17:76127802G>A	uc002jup.2	+	2	515	c.133G>A	c.(133-135)GAC>AAC	p.D45N	TMC6_uc010dhf.1_5'Flank|TMC6_uc002juk.2_5'Flank|TMC6_uc010dhg.1_5'Flank|TMC6_uc002jul.1_Intron|TMC6_uc002jun.3_5'Flank|TMC6_uc002juo.2_5'Flank|TMC6_uc010wtq.1_5'Flank|TMC8_uc010dhh.1_Missense_Mutation_p.D45N|TMC8_uc002juq.2_Intron|TMC8_uc010wtr.1_5'Flank	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	45	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			TGCCATGATGGACAAGCGCCT	0.736000									Epidermodysplasia_Verruciformis_Familial_Clustering_of			
LAMA1	284217	broad.mit.edu	37	18	7043226	7043226	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr18:7043226T>G	uc002knm.2	-	8	1249	c.1155A>C	c.(1153-1155)AAA>AAC	p.K385N	LAMA1_uc010wzj.1_5'UTR	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	385	Laminin EGF-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATACTCTTACTTTGTGTGGTC	0.403000												
DCC	1630	broad.mit.edu	37	18	50848502	50848502	+	Silent	SNP	A	A	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr18:50848502A>T	uc002lfe.1	+	14	2726	c.2139A>T	c.(2137-2139)GCA>GCT	p.A713A	DCC_uc010xdr.1_Silent_p.A561A|DCC_uc010dpf.1_Silent_p.A368A	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	713	Extracellular (Potential).|Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GGTATACTGCAGAGACTCCAG	0.403000												
CDH7	1005	broad.mit.edu	37	18	63530059	63530059	+	Silent	SNP	A	A	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr18:63530059A>G	uc002ljz.2	+	11	2095	c.1770A>G	c.(1768-1770)GTA>GTG	p.V590V	CDH7_uc002lka.2_Silent_p.V590V|CDH7_uc002lkb.2_Silent_p.V590V	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	590	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CTGACGGCGTAGCCCAGACCT	0.527000												
ZNF407	55628	broad.mit.edu	37	18	72346747	72346747	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr18:72346747C>T	uc002llw.2	+	1	3829	c.3772C>T	c.(3772-3774)CGC>TGC	p.R1258C	ZNF407_uc010xfc.1_Missense_Mutation_p.R1258C|ZNF407_uc010dqu.1_Missense_Mutation_p.R1258C|ZNF407_uc002llu.2_Missense_Mutation_p.R1257C	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CGATGGGGAGCGCTCGGCTGA	0.577000												
MUC16	94025	broad.mit.edu	37	19	9059857	9059857	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:9059857T>A	uc002mkp.2	-	3	27793	c.27589A>T	c.(27589-27591)ACC>TCC	p.T9197S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9199	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGAACTGGTTTCAGGTTCT	0.498000												
MUC16	94025	broad.mit.edu	37	19	9072191	9072191	+	Silent	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:9072191T>G	uc002mkp.2	-	3	15459	c.15255A>C	c.(15253-15255)ACA>ACC	p.T5085T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5087	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTTCCAAGCGTGTACGTAATA	0.433000												
MUC16	94025	broad.mit.edu	37	19	9073279	9073279	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:9073279C>A	uc002mkp.2	-	3	14371	c.14167G>T	c.(14167-14169)GCA>TCA	p.A4723S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4725	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGTTCATTGCAGTGGTTATT	0.483000												
CHERP	10523	broad.mit.edu	37	19	16638979	16638979	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:16638979C>T	uc002nei.1	-	9	1291	c.1217G>A	c.(1216-1218)CGG>CAG	p.R406Q	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_5'Flank	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	406	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						cccggggccccgggggccggc	0.507000												
MRPL34	64981	broad.mit.edu	37	19	17416747	17416747	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:17416747G>C	uc002ngc.1	+	1	271	c.46G>C	c.(46-48)GCA>CCA	p.A16P	ABHD8_uc002ngb.3_5'Flank	NM_023937	NP_076426	Q9BQ48	RM34_HUMAN	mitochondrial ribosomal protein L34 precursor	16					translation		structural constituent of ribosome				0						GAGTAGGTCGGCAGCGTTGCT	0.662000												
CRTC1	23373	broad.mit.edu	37	19	18886480	18886480	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:18886480C>T	uc002nkb.3	+	13	1630	c.1542C>T	c.(1540-1542)GCC>GCT	p.A514A	CRTC1_uc010ebv.2_Silent_p.A530A|CRTC1_uc010ebw.2_Silent_p.A350A|CRTC1_uc002nkc.3_Silent_p.A212A	NM_015321	NP_056136	Q6UUV9	CRTC1_HUMAN	mucoepidermoid carcinoma translocated 1 isoform	514					interspecies interaction between organisms|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	cAMP response element binding protein binding|protein binding		CRTC1/MAML2(516)	salivary_gland(474)|lung(35)|thyroid(4)|breast(3)|skin(2)|ovary(1)	519						TGGAGAACGCCATCAGCTCCA	0.677000												
ZNF493	284443	broad.mit.edu	37	19	21606384	21606384	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:21606384T>A	uc002npx.2	+	2	819	c.539T>A	c.(538-540)CTT>CAT	p.L180H	ZNF493_uc002npw.2_Missense_Mutation_p.L308H|ZNF493_uc002npy.2_Missense_Mutation_p.L180H	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	180	C2H2-type 6; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTTCAACCCTTACTGGACAT	0.328000												
ZNF43	7594	broad.mit.edu	37	19	22002007	22002007	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:22002007A>G	uc002nqj.2	-	2	150	c.20T>C	c.(19-21)ATG>ACG	p.M7T	ZNF43_uc010ecv.2_Missense_Mutation_p.M1T|ZNF43_uc002nql.2_Missense_Mutation_p.M1T|ZNF43_uc002nqm.2_Missense_Mutation_p.M1T|ZNF43_uc002nqk.2_Intron	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	7	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GGCCACATCCATAAATGTCAA	0.393000												
TSHZ3	57616	broad.mit.edu	37	19	31768179	31768179	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:31768179G>A	uc002nsy.3	-	2	2585	c.2520C>T	c.(2518-2520)CGC>CGT	p.R840R		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	840					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					AGGCATTCTCGCGTAGCGGCG	0.522000												
ZNF382	84911	broad.mit.edu	37	19	37117123	37117123	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:37117123A>C	uc002oek.2	+	5	437	c.324A>C	c.(322-324)AAA>AAC	p.K108N	ZNF382_uc010efa.2_Missense_Mutation_p.K59N|ZNF382_uc010efb.2_Missense_Mutation_p.K107N|ZNF382_uc002oel.2_Missense_Mutation_p.K107N	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	108	Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ACCACAAAAAACTAATTAAGG	0.328000												
ERF	2077	broad.mit.edu	37	19	42753425	42753425	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:42753425G>A	uc002ote.3	-	4	997	c.839C>T	c.(838-840)TCG>TTG	p.S280L	ERF_uc002otd.3_Missense_Mutation_p.S11L	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	280					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				CAGCGTGGGCGAGGGAGTGTA	0.692000												
BCAT2	587	broad.mit.edu	37	19	49310309	49310309	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:49310309G>A	uc002pkr.2	-	2	84	c.47C>T	c.(46-48)TCT>TTT	p.S16F	BCAT2_uc002pkp.2_5'UTR|BCAT2_uc002pkq.3_5'UTR|BCAT2_uc002pks.2_5'UTR|BCAT2_uc002pkt.2_Intron|BCAT2_uc010emh.1_Missense_Mutation_p.S16F|BCAT2_uc010emi.1_Intron|BCAT2_uc002pku.1_5'UTR|BCAT2_uc010emj.1_RNA	NM_001190	NP_001181	O15382	BCAT2_HUMAN	branched chain aminotransferase 2, mitochondrial	16						mitochondrial matrix	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			ovary(1)	1		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.000366)|Epithelial(262;0.0195)|GBM - Glioblastoma multiforme(486;0.0224)	L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|Pyridoxal Phosphate(DB00114)	CCAAGGGACAGAGAGAAGCTT	0.597000												
KLK4	9622	broad.mit.edu	37	19	51411894	51411894	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:51411894G>A	uc002pua.1	-	3	416	c.416C>T	c.(415-417)TCG>TTG	p.S139L	KLK4_uc002pty.1_Missense_Mutation_p.S90L|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_Missense_Mutation_p.S44L|KLK4_uc002puc.1_RNA|KLK4_uc010eoi.1_Missense_Mutation_p.S44L|KLK4_uc002pud.1_Missense_Mutation_p.S44L	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	139	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		AGGGCACTGCGAAGCAATGCT	0.587000												
SIGLEC10	89790	broad.mit.edu	37	19	51920007	51920007	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr19:51920007G>A	uc002pwo.2	-	3	1235	c.619C>T	c.(619-621)CAG>TAG	p.Q207*	SIGLEC10_uc002pwp.2_Nonsense_Mutation_p.Q149*|SIGLEC10_uc002pwq.2_Nonsense_Mutation_p.Q149*|SIGLEC10_uc002pwr.2_Nonsense_Mutation_p.Q207*|SIGLEC10_uc010ycy.1_Nonsense_Mutation_p.Q207*|SIGLEC10_uc010ycz.1_Nonsense_Mutation_p.Q159*|SIGLEC10_uc010eow.2_5'UTR|SIGLEC10_uc002pws.1_Nonsense_Mutation_p.Q133*	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	207	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		TTGTGGTCCTGGGGTCTGGGC	0.617000												
TAF1B	9014	broad.mit.edu	37	2	10059894	10059894	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:10059894T>G	uc002qzz.2	+	14	1610	c.1510T>G	c.(1510-1512)TCA>GCA	p.S504A	TAF1B_uc002qzy.3_Missense_Mutation_p.S504A|TAF1B_uc010yja.1_Missense_Mutation_p.S249A|TAF1B_uc010exd.2_Missense_Mutation_p.S249A	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	504					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GAAAGGCCAATCACTGCTGAC	0.388000												
C2orf16	84226	broad.mit.edu	37	2	27801239	27801239	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:27801239C>T	uc002rkz.3	+	1	1851	c.1800C>T	c.(1798-1800)ATC>ATT	p.I600I		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	600										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CCCTTCAAATCGTAAAATCTG	0.393000												
TGFBRAP1	9392	broad.mit.edu	37	2	105924384	105924384	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:105924384G>A	uc002tcq.2	-	2	459	c.375C>T	c.(373-375)AAC>AAT	p.N125N	TGFBRAP1_uc002tcr.3_Silent_p.N125N	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	125	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						CAGGGTTCTCGTTCAGTGCAA	0.567000												
C2orf40	84417	broad.mit.edu	37	2	106694260	106694260	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:106694260C>T	uc010fjf.2	+	4	433	c.325C>T	c.(325-327)CGA>TGA	p.R109*		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	109						extracellular region|transport vesicle					0						TAACAGAGATCGAAATGGACA	0.453000												
CNTNAP5	129684	broad.mit.edu	37	2	125262112	125262112	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:125262112C>T	uc002tno.2	+	8	1667	c.1303C>T	c.(1303-1305)CGC>TGC	p.R435C	CNTNAP5_uc010flu.2_Missense_Mutation_p.R436C	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	435	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AATGACAGAACGCGTAGCTGA	0.507000												
LRP1B	53353	broad.mit.edu	37	2	141108422	141108422	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:141108422T>C	uc002tvj.1	-	77	12808	c.11836A>G	c.(11836-11838)ATT>GTT	p.I3946V		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3946	Extracellular (Potential).|LDL-receptor class B 33.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGTAGAAAATTCCGCCTGGA	0.333000										TSP Lung(27;0.18)		
ZEB2	9839	broad.mit.edu	37	2	145156170	145156170	+	Silent	SNP	A	A	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:145156170A>G	uc002tvu.2	-	8	3064	c.2584T>C	c.(2584-2586)TTG>CTG	p.L862L	ZEB2_uc002tvv.2_Silent_p.L856L|ZEB2_uc010zbm.1_Silent_p.L833L|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Silent_p.L891L	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	862						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		ATAAAAGTCAAGTTCAGAGGC	0.348000												
RBM43	375287	broad.mit.edu	37	2	152107515	152107515	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:152107515G>A	uc002txh.2	-	4	1127	c.979C>T	c.(979-981)CTT>TTT	p.L327F		NM_198557	NP_940959	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	327							nucleotide binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		GTCCTATAAAGGTTAATCAGG	0.328000												
SCN1A	6323	broad.mit.edu	37	2	166901827	166901827	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:166901827G>A	uc010zcz.1	-	10	1406	c.1388C>T	c.(1387-1389)ACG>ATG	p.T463M	SCN1A_uc002udo.3_Missense_Mutation_p.T332M|SCN1A_uc010fpk.2_Missense_Mutation_p.T332M	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	463						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GGCAGTTGCCGTTGCTGCCTG	0.443000												
GAD1	2571	broad.mit.edu	37	2	171687619	171687619	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:171687619A>C	uc002ugi.2	+	5	886	c.464A>C	c.(463-465)AAC>ACC	p.N155T	GAD1_uc002ugh.2_Missense_Mutation_p.N155T	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	155				N -> T (in Ref. 6; AAB26938).	glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GAGGGCTTCAACTTGGAGCTC	0.542000												
TTN	7273	broad.mit.edu	37	2	179578722	179578722	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:179578722T>G	uc010zfg.1	-	89	23155	c.22931A>C	c.(22930-22932)AAG>ACG	p.K7644T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K4305T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8571							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.K7644R(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGATGATCTTAAGGCCGGA	0.443000												
TTN	7273	broad.mit.edu	37	2	179604456	179604456	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:179604456T>G	uc010zfh.1	-	46	13215	c.12991A>C	c.(12991-12993)AGT>CGT	p.S4331R	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.S4264R|TTN_uc010zfj.1_Missense_Mutation_p.S4139R|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	4256							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTGCAAACTTGTTTTGGCT	0.388000												
ITGAV	3685	broad.mit.edu	37	2	187466848	187466848	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:187466848C>T	uc002upq.2	+	2	562	c.286C>T	c.(286-288)CGG>TGG	p.R96W	ITGAV_uc010frs.2_Missense_Mutation_p.R96W|ITGAV_uc010zfv.1_Missense_Mutation_p.R50W	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	96	FG-GAP 1.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TTCTACCCGCCGGTGCCAGCC	0.433000												
AOX1	316	broad.mit.edu	37	2	201485953	201485953	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:201485953T>C	uc002uvx.2	+	18	2086	c.1985T>C	c.(1984-1986)TTT>TCT	p.F662S	AOX1_uc010zhf.1_Missense_Mutation_p.F218S|AOX1_uc010fsu.2_Missense_Mutation_p.F28S	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	662					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GCTGAGAAATTTCTGGCGACA	0.398000												
MAP2	4133	broad.mit.edu	37	2	210559838	210559838	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:210559838G>C	uc002vde.1	+	7	3192	c.2944G>C	c.(2944-2946)GAG>CAG	p.E982Q	MAP2_uc002vdc.1_Missense_Mutation_p.E982Q|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.E978Q	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	982					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GAAAACTGAAGAGGCTGGTGA	0.398000												
ERBB4	2066	broad.mit.edu	37	2	212248599	212248599	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:212248599T>G	uc002veg.1	-	28	3766	c.3668A>C	c.(3667-3669)AAG>ACG	p.K1223T	ERBB4_uc002veh.1_Missense_Mutation_p.K1207T|ERBB4_uc010zji.1_Missense_Mutation_p.K1213T|ERBB4_uc010zjj.1_Missense_Mutation_p.K1197T	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1223	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TATGTTGTTCTTCAGGTACTC	0.517000										TSP Lung(8;0.080)		
VWC2L	402117	broad.mit.edu	37	2	215440504	215440504	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:215440504A>C	uc002vet.2	+	4	759	c.629A>C	c.(628-630)CAG>CCG	p.Q210P	VWC2L_uc010zjl.1_3'UTR	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	210						extracellular region					0						AAGCCTGCTCAGTGTTCGAAA	0.478000												
DOCK10	55619	broad.mit.edu	37	2	225702525	225702525	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:225702525T>A	uc010fwz.1	-	25	3043	c.2804A>T	c.(2803-2805)AAG>ATG	p.K935M	DOCK10_uc002vob.2_Missense_Mutation_p.K929M	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	935							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTCATGGCACTTGGCCACAAT	0.468000												
COL4A4	1286	broad.mit.edu	37	2	227896700	227896700	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:227896700G>A	uc010zlt.1	-	40	4432	c.3778C>T	c.(3778-3780)CCT>TCT	p.P1260S		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1260	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGATCTCCAGGTGGACCCGGG	0.542000												
PTPRA	5786	broad.mit.edu	37	20	2988067	2988067	+	Splice_Site	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr20:2988067G>A	uc010zqd.1	+	10	1256	c.939_splice	c.e10+1	p.N313_splice	PTPRA_uc002whj.2_Splice_Site_p.N302_splice|PTPRA_uc002whk.2_Splice_Site_p.N293_splice|PTPRA_uc002whl.2_Splice_Site_p.N293_splice|PTPRA_uc002whm.2_Splice_Site_p.N69_splice|PTPRA_uc002whn.2_Splice_Site_p.N293_splice|PTPRA_uc002who.2_Splice_Site	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A						axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						ATTCATCAACGTAAGGATCGG	0.458000												
ProSAPiP1	9762	broad.mit.edu	37	20	3146426	3146426	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr20:3146426G>A	uc002wia.1	-	2	2438	c.1040C>T	c.(1039-1041)GCG>GTG	p.A347V	ProSAPiP1_uc002wib.1_Missense_Mutation_p.A347V	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	347	Potential.					cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						GGCCACAGCCGCCTCGCTCTG	0.711000												
ESF1	51575	broad.mit.edu	37	20	13756707	13756707	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr20:13756707C>T	uc002woj.2	-	3	955	c.847G>A	c.(847-849)GAG>AAG	p.E283K	ESF1_uc002wok.1_Missense_Mutation_p.E283K	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	283	Asp-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						tcatcctcctcttcatcttca	0.234000												
MYH7B	57644	broad.mit.edu	37	20	33577664	33577664	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr20:33577664G>A	uc002xbi.1	+	18	1927	c.1835G>A	c.(1834-1836)CGG>CAG	p.R612Q	MIR499_hsa-mir-499|MI0003183_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	570	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CAGCAGCCTCGGCCTGACAAG	0.632000												
LPIN3	64900	broad.mit.edu	37	20	39977772	39977772	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr20:39977772A>G	uc002xjx.2	+	5	689	c.598A>G	c.(598-600)ATC>GTC	p.I200V	LPIN3_uc010ggh.2_Missense_Mutation_p.I201V|LPIN3_uc010zwf.1_RNA	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	lipin 3	200					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(115;0.000739)				GCCCAAAGACATCTACCCCTA	0.547000												
CSTF1	1477	broad.mit.edu	37	20	54970640	54970640	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr20:54970640G>A	uc002xxl.1	+	2	232	c.32G>A	c.(31-33)CGC>CAC	p.R11H	CSTF1_uc002xxm.1_Missense_Mutation_p.R11H|CSTF1_uc002xxn.1_Missense_Mutation_p.R11H|CSTF1_uc002xxo.1_5'UTR	NM_001033521	NP_001028693	Q05048	CSTF1_HUMAN	cleavage stimulation factor subunit 1	11					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(1)	1			Colorectal(105;0.202)			TTGAAGGACCGCCAGCAGCTC	0.498000												
ZNF831	128611	broad.mit.edu	37	20	57766527	57766527	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr20:57766527C>T	uc002yan.2	+	1	453	c.453C>T	c.(451-453)CGC>CGT	p.R151R		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	151	C2H2-type 1.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					ACTGTGGTCGCGACTGCCTGA	0.657000												
ADAMTS5	11096	broad.mit.edu	37	21	28338124	28338124	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr21:28338124T>C	uc002ymg.2	-	1	1316	c.587A>G	c.(586-588)GAG>GGG	p.E196G		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	196					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GCTGAAGCCCTCGCGGGTGTA	0.697000												
ADAMTS5	11096	broad.mit.edu	37	21	28338580	28338580	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr21:28338580C>T	uc002ymg.2	-	1	860	c.131G>A	c.(130-132)CGC>CAC	p.R44H		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	44					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CTGCCGCCGGCGGGGCTGGGC	0.766000												
SMC1B	27127	broad.mit.edu	37	22	45767386	45767386	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr22:45767386G>A	uc003bgc.2	-	14	2330	c.2278C>T	c.(2278-2280)CGA>TGA	p.R760*	SMC1B_uc003bgd.2_Nonsense_Mutation_p.R760*|SMC1B_uc003bge.1_Nonsense_Mutation_p.R543*	NM_148674	NP_683515	Q8NDV3	SMC1B_HUMAN	SMC1 structural maintenance of chromosomes	760	Potential.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			ovary(2)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TTAATTCTTCGTTGTCGTTCC	0.299000												
BHLHE40	8553	broad.mit.edu	37	3	5025133	5025133	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:5025133C>T	uc003bqf.2	+	5	1302	c.995C>T	c.(994-996)GCG>GTG	p.A332V	BHLHE40_uc011asw.1_Missense_Mutation_p.A192V	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	332						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCACCTTCAGCGACTGCCTAC	0.607000												
ATP2B2	491	broad.mit.edu	37	3	10442664	10442664	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:10442664C>T	uc003bvt.2	-	5	1193	c.754G>A	c.(754-756)GTG>ATG	p.V252M	ATP2B2_uc003bvv.2_Missense_Mutation_p.V252M|ATP2B2_uc003bvw.2_Missense_Mutation_p.V252M|ATP2B2_uc010hdp.2_Missense_Mutation_p.V252M|ATP2B2_uc010hdo.2_Translation_Start_Site	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	252	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TCCTTGTCCACGGACTTGCGC	0.587000												
SLC25A38	54977	broad.mit.edu	37	3	39430993	39430993	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:39430993C>T	uc003cjo.2	+	2	478	c.77C>T	c.(76-78)CCG>CTG	p.P26L		NM_017875	NP_060345	Q96DW6	S2538_HUMAN	solute carrier family 25, member 38	26	Solcar 1.				erythrocyte differentiation|heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CAGTTACATCCGGTGATCAAG	0.488000												
ST3GAL6	10402	broad.mit.edu	37	3	98489735	98489735	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:98489735G>A	uc003dsz.2	+	3	338	c.102G>A	c.(100-102)GTG>GTA	p.V34V	ST3GAL6_uc003dsy.2_5'UTR|ST3GAL6_uc003dta.2_5'UTR|ST3GAL6_uc003dtb.2_Intron|ST3GAL6_uc003dtc.2_Silent_p.V34V|ST3GAL6_uc010hpd.2_Silent_p.V87V	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	34	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						TGGCACCTGTGGAAATGAAAC	0.448000												
PIK3CB	5291	broad.mit.edu	37	3	138461469	138461469	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:138461469G>A	uc011bmq.1	-	3	552	c.552C>T	c.(550-552)ATC>ATT	p.I184I		NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	184	PI3K-RBD.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						AGTTTTCAGGGATGGATGGTT	0.368000												
SLC25A36	55186	broad.mit.edu	37	3	140692763	140692763	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:140692763G>A	uc003etr.2	+	6	893	c.658G>A	c.(658-660)GTG>ATG	p.V220M	SLC25A36_uc003ets.2_Missense_Mutation_p.V220M|SLC25A36_uc003etq.2_Missense_Mutation_p.V63M|SLC25A36_uc011bmz.1_Missense_Mutation_p.V194M	NM_001104647	NP_001098117	Q96CQ1	S2536_HUMAN	solute carrier family 25, member 36 isoform a	220					response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						TGAAGAGTCTGTGAAAGAAGC	0.348000												
SI	6476	broad.mit.edu	37	3	164709261	164709261	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:164709261T>G	uc003fei.2	-	44	5050	c.4988A>C	c.(4987-4989)AAA>ACA	p.K1663T		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1663	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCCAATATCTTTGCCCTGGAA	0.393000										HNSCC(35;0.089)		
KCNMB2	10242	broad.mit.edu	37	3	178546118	178546118	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:178546118T>G	uc003fjd.2	+	4	723	c.380T>G	c.(379-381)CTC>CGC	p.L127R	uc003fjb.1_Intron|uc003fjc.1_Intron|KCNMB2_uc003fje.2_Missense_Mutation_p.L127R|KCNMB2_uc003fjf.2_Missense_Mutation_p.L127R|KCNMB2_uc011bqa.1_Intron|KCNMB2_uc011bqb.1_Intron	NM_181361	NP_852006	Q9Y691	KCMB2_HUMAN	calcium-activated potassium channel beta 2	127	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(1)	1	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			GGGGAAAAGCTCCTCCTCTAC	0.483000												
ECE2	9718	broad.mit.edu	37	3	184009886	184009886	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:184009886G>A	uc003fni.3	+	19	2550	c.2512G>A	c.(2512-2514)GAG>AAG	p.E838K	ECE2_uc003fnl.3_Missense_Mutation_p.E766K|ECE2_uc003fnm.3_Missense_Mutation_p.E720K|ECE2_uc003fnk.3_Missense_Mutation_p.E691K	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	838	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAGCTCTCACGAGGGGCTGGT	0.667000												
TMEM44	93109	broad.mit.edu	37	3	194331653	194331653	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr3:194331653C>A	uc010hzn.2	-	9	1319	c.1150G>T	c.(1150-1152)GTG>TTG	p.V384L	TMEM44_uc010hzm.2_Missense_Mutation_p.V69L|TMEM44_uc003fuc.2_Missense_Mutation_p.V69L|TMEM44_uc003fue.2_Missense_Mutation_p.V337L|TMEM44_uc003fud.2_Missense_Mutation_p.V337L|TMEM44_uc003fuf.2_Missense_Mutation_p.V337L|TMEM44_uc011bsv.1_Missense_Mutation_p.V337L|TMEM44_uc003fuh.1_RNA	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	384	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		ACCTGCTGCACAGGCTCGATG	0.423000												
RGS12	6002	broad.mit.edu	37	4	3318204	3318204	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr4:3318204G>A	uc003ggw.2	+	2	1211	c.307G>A	c.(307-309)GAA>AAA	p.E103K	RGS12_uc003ggu.2_Missense_Mutation_p.E103K|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Missense_Mutation_p.E103K|RGS12_uc003ggx.1_Missense_Mutation_p.E103K	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	103						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CGGCCGCTTCGAATCCTGTTC	0.468000												
STK32B	55351	broad.mit.edu	37	4	5468557	5468557	+	Missense_Mutation	SNP	C	C	T	rs146908689		TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr4:5468557C>T	uc003gih.1	+	10	1101	c.1037C>T	c.(1036-1038)CCG>CTG	p.P346L	STK32B_uc010ida.1_Missense_Mutation_p.P299L	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	346							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GACAGCTGCCCGCTGGTGAGT	0.493000												
FRYL	285527	broad.mit.edu	37	4	48592824	48592824	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr4:48592824G>A	uc003gyh.1	-	17	1964	c.1359C>T	c.(1357-1359)GTC>GTT	p.V453V	FRYL_uc003gyk.2_Silent_p.V453V	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	453					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TTACAAGGAAGACTCTGAGAC	0.368000												
MAPK10	5602	broad.mit.edu	37	4	87028500	87028500	+	Missense_Mutation	SNP	G	G	A	rs143720396		TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr4:87028500G>A	uc003hpq.2	-	4	309	c.242C>T	c.(241-243)GCG>GTG	p.A81V	MAPK10_uc010ikg.2_Missense_Mutation_p.A43V|MAPK10_uc003hpr.2_Missense_Mutation_p.A43V|MAPK10_uc003hps.2_Missense_Mutation_p.A81V|MAPK10_uc003hpt.2_Missense_Mutation_p.A81V|MAPK10_uc003hpu.2_Missense_Mutation_p.A81V|MAPK10_uc003hpv.2_5'UTR|MAPK10_uc010ikh.1_RNA|MAPK10_uc003hpo.2_5'UTR|MAPK10_uc011ccw.1_5'UTR|MAPK10_uc003hpp.2_5'UTR	NM_138982	NP_620448	P53779	MK10_HUMAN	mitogen-activated protein kinase 10 isoform 2	81	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			stomach(1)|breast(1)|central_nervous_system(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		AGCATCATACGCGGCACTGTA	0.443000												
FSTL5	56884	broad.mit.edu	37	4	162307513	162307513	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr4:162307513C>A	uc003iqh.2	-	16	2366	c.1930G>T	c.(1930-1932)GAC>TAC	p.D644Y	FSTL5_uc003iqi.2_Missense_Mutation_p.D643Y|FSTL5_uc010iqv.2_Missense_Mutation_p.D634Y|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	644						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CACTTATAGTCCTTCAAGTTA	0.403000												
GALNTL6	442117	broad.mit.edu	37	4	173730599	173730599	+	Missense_Mutation	SNP	G	G	A	rs146548110		TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr4:173730599G>A	uc003isv.2	+	6	1377	c.641G>A	c.(640-642)CGG>CAG	p.R214Q		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	214	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GGACTCATCCGGACCCGTCTC	0.517000												
TUBB4Q	56604	broad.mit.edu	37	4	190905444	190905444	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr4:190905444G>A	uc011clg.1	-	3	243	c.240C>T	c.(238-240)TTC>TTT	p.F80F		NM_020040	NP_064424	Q99867	TBB4Q_HUMAN	tubulin, beta polypeptide 4, member Q	81					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;4.1e-31)|Epithelial(3;1.44e-30)|OV - Ovarian serous cystadenocarcinoma(60;2.03e-15)|BRCA - Breast invasive adenocarcinoma(30;8.54e-06)|Lung(3;3.23e-05)|STAD - Stomach adenocarcinoma(60;8.24e-05)|LUSC - Lung squamous cell carcinoma(40;0.000184)|GBM - Glioblastoma multiforme(59;0.00839)|READ - Rectum adenocarcinoma(43;0.155)		AGACCTGCCCGAAGGGCCCCG	0.667000												
IRX1	79192	broad.mit.edu	37	5	3599410	3599410	+	Silent	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr5:3599410T>G	uc003jde.2	+	2	400	c.348T>G	c.(346-348)GCT>GCG	p.A116A		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	116						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CGGCGCCGGCTTATTACCCCT	0.652000												
ADAMTS16	170690	broad.mit.edu	37	5	5239336	5239336	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr5:5239336T>C	uc003jdl.2	+	15	2365	c.2227T>C	c.(2227-2229)TCA>CCA	p.S743P	ADAMTS16_uc003jdk.1_Missense_Mutation_p.S743P|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	743	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CGGGAATAACTCAGCCTGCAC	0.512000												
TRIO	7204	broad.mit.edu	37	5	14504649	14504649	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr5:14504649C>T	uc003jff.2	+	55	8565	c.8559C>T	c.(8557-8559)GTC>GTT	p.V2853V	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2853	Protein kinase.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CCCTGCTTGTCGGCCTCCTCG	0.587000												
IL7R	3575	broad.mit.edu	37	5	35876425	35876425	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr5:35876425T>G	uc003jjs.2	+	8	1306	c.1217T>G	c.(1216-1218)CTT>CGT	p.L406R	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	406	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GACCTCCTGCTTAGCCTTGGG	0.532000												
HCN1	348980	broad.mit.edu	37	5	45645353	45645353	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr5:45645353T>G	uc003jok.2	-	2	808	c.783A>C	c.(781-783)AAA>AAC	p.K261N		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	261	Helical; Voltage-sensor; Name=Segment S4; (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						GACTGAGAATTTTTGTAAACC	0.343000												
APC	324	broad.mit.edu	37	5	112151261	112151261	+	Nonsense_Mutation	SNP	C	C	T	rs137854568		TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr5:112151261C>T	uc010jby.2	+	9	1284	c.904C>T	c.(904-906)CGA>TGA	p.R302*	APC_uc011cvt.1_Nonsense_Mutation_p.R284*|APC_uc003kpz.3_Nonsense_Mutation_p.R302*|APC_uc003kpy.3_Nonsense_Mutation_p.R302*|APC_uc010jbz.2_Nonsense_Mutation_p.R19*	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	302	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.R302*(10)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CTCTGCACCTCGAAGGCTGAC	0.388000		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)		
ZNF474	133923	broad.mit.edu	37	5	121488479	121488479	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr5:121488479A>C	uc003ksv.2	+	2	1170	c.794A>C	c.(793-795)AAG>ACG	p.K265T		NM_207317	NP_997200	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	265						intracellular	zinc ion binding				0		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		CTCCCACAGAAGCCTCAGCCC	0.552000												
SLC12A2	6558	broad.mit.edu	37	5	127510310	127510310	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr5:127510310G>T	uc003kus.2	+	20	3045	c.2881G>T	c.(2881-2883)GAT>TAT	p.D961Y	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.D961Y	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	961	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TAAAAAGTCCGATTTAGATAC	0.308000												
F13A1	2162	broad.mit.edu	37	6	6145969	6145969	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:6145969T>G	uc003mwv.2	-	15	2205	c.2082A>C	c.(2080-2082)GAA>GAC	p.E694D	F13A1_uc011dib.1_Missense_Mutation_p.K588T	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	694					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GCCGGCACACTTCTTCCCACT	0.537000												
ABCF1	23	broad.mit.edu	37	6	30550930	30550930	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:30550930C>T	uc003nql.2	+	10	975	c.880C>T	c.(880-882)CGC>TGC	p.R294C	ABCF1_uc003nqk.2_Missense_Mutation_p.R295C|ABCF1_uc003nqm.2_Missense_Mutation_p.R256C|ABCF1_uc010jsb.2_Intron|MIR877_hsa-mir-877|MI0005561_5'Flank	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	294					inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						GATGTCCTCCCGCCAAGCCAT	0.517000												
MCCD1	401250	broad.mit.edu	37	6	31496954	31496954	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:31496954C>T	uc003ntp.1	+	1	216	c.163C>T	c.(163-165)CCT>TCT	p.P55S		NM_001011700	NP_001011700	P59942	MCCD1_HUMAN	mitochondrial coiled-coil domain 1 precursor	55						mitochondrion					0						GATGACGTCCCCTCCCAGGGT	0.567000												
TNXB	7148	broad.mit.edu	37	6	32020588	32020588	+	Silent	SNP	G	G	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:32020588G>T	uc003nzl.2	-	26	9170	c.8968C>A	c.(8968-8970)CGG>AGG	p.R2990R		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3037	Fibronectin type-III 22.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACCTGGGGCCGCCCGTCCCTG	0.657000												
FAM83B	222584	broad.mit.edu	37	6	54806564	54806564	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:54806564G>A	uc003pck.2	+	5	2911	c.2795G>A	c.(2794-2796)CGT>CAT	p.R932H		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	932										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					ACTGATCGGCGTGTTTACAGT	0.428000												
BAI3	577	broad.mit.edu	37	6	70071081	70071081	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:70071081A>C	uc003pev.3	+	29	4364	c.3916A>C	c.(3916-3918)AGT>CGT	p.S1306R	BAI3_uc010kak.2_Missense_Mutation_p.S1306R|BAI3_uc011dxx.1_Missense_Mutation_p.S512R	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1306	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AATGATGGAAAGTGACTATAT	0.393000												
LMBRD1	55788	broad.mit.edu	37	6	70423647	70423647	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:70423647A>C	uc003pfa.2	-	9	920	c.805T>G	c.(805-807)TTA>GTA	p.L269V	LMBRD1_uc003pey.2_Missense_Mutation_p.L65V|LMBRD1_uc003pez.2_Missense_Mutation_p.L196V|LMBRD1_uc010kal.2_Missense_Mutation_p.L196V|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	269	Cytoplasmic (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						AATTGTTTTAAGGCGCGTTTA	0.383000												
FILIP1	27145	broad.mit.edu	37	6	76063321	76063321	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:76063321T>A	uc003pia.2	-	4	936	c.563A>T	c.(562-564)CAT>CTT	p.H188L	FILIP1_uc003phy.1_Missense_Mutation_p.H188L|FILIP1_uc003phz.2_Missense_Mutation_p.H89L|FILIP1_uc010kbe.2_Missense_Mutation_p.H191L	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	188										skin(3)|ovary(1)	4						AGTGTGTTTATGCTTCTCGTT	0.517000												
PHIP	55023	broad.mit.edu	37	6	79664656	79664656	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:79664656G>A	uc003pir.2	-	35	4154	c.3928C>T	c.(3928-3930)CGT>TGT	p.R1310C	PHIP_uc003piq.2_Missense_Mutation_p.R334C|PHIP_uc011dyp.1_Missense_Mutation_p.R1309C|PHIP_uc003pio.3_Missense_Mutation_p.R196C	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1310					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	6		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		GCTCTATTACGTAATCTTCTT	0.328000												
ASCC3	10973	broad.mit.edu	37	6	100960674	100960674	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:100960674G>A	uc003pqk.2	-	40	6525	c.6196C>T	c.(6196-6198)CGA>TGA	p.R2066*		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	2066					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTGTCATCTCGTTTGTCTGCA	0.428000												
FIG4	9896	broad.mit.edu	37	6	110064385	110064385	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:110064385A>C	uc003ptt.2	+	9	1164	c.949A>C	c.(949-951)AGT>CGT	p.S317R	FIG4_uc011eau.1_Intron	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	317	SAC.				cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CACTGCAGGAAGTTATTCTTC	0.398000												
UTRN	7402	broad.mit.edu	37	6	144780063	144780063	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:144780063C>G	uc003qkt.2	+	19	2534	c.2442C>G	c.(2440-2442)ATC>ATG	p.I814M	UTRN_uc010khq.1_Missense_Mutation_p.I814M	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	814	Interaction with SYNM.|Spectrin 6.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AAAAGGTCATCAAGACAAAGG	0.418000												
SYNE1	23345	broad.mit.edu	37	6	152671358	152671358	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:152671358T>A	uc010kiw.2	-	72	12448	c.11846A>T	c.(11845-11847)GAC>GTC	p.D3949V	SYNE1_uc003qot.3_Intron|SYNE1_uc003qou.3_Missense_Mutation_p.D3949V|SYNE1_uc010kja.1_Missense_Mutation_p.D654V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3949	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCCAGGAGGTCAGGTGCCAC	0.542000										HNSCC(10;0.0054)		
FNDC1	84624	broad.mit.edu	37	6	159660666	159660666	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr6:159660666C>T	uc010kjv.2	+	14	4498	c.4298C>T	c.(4297-4299)CCG>CTG	p.P1433L	FNDC1_uc010kjw.1_Missense_Mutation_p.P1318L	NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1433						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GGAGGAAAGCCGCTGGTGGGC	0.453000												
C7orf27	221927	broad.mit.edu	37	7	2578824	2578824	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:2578824C>T	uc003smi.2	-	13	1801	c.1759G>A	c.(1759-1761)GAG>AAG	p.E587K	C7orf27_uc003smh.3_Missense_Mutation_p.E19K	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	587					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		TGCCGGGCCTCTGCATGCTCA	0.672000												
DGKB	1607	broad.mit.edu	37	7	14724974	14724974	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:14724974T>G	uc003ssz.2	-	9	912	c.725A>C	c.(724-726)GAT>GCT	p.D242A	DGKB_uc011jxt.1_Missense_Mutation_p.D235A|DGKB_uc003sta.2_Missense_Mutation_p.D242A|DGKB_uc011jxu.1_Missense_Mutation_p.D242A|DGKB_uc011jxv.1_Missense_Mutation_p.D242A	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	242					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	GTGCTGTCCATCATCCTTCAC	0.463000												
STK31	56164	broad.mit.edu	37	7	23871800	23871800	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:23871800A>C	uc003sws.3	+	24	2942	c.2875A>C	c.(2875-2877)AGT>CGT	p.S959R	STK31_uc003swt.3_Missense_Mutation_p.S936R|STK31_uc011jze.1_Missense_Mutation_p.S936R|STK31_uc010kuq.2_Missense_Mutation_p.S936R|STK31_uc003swv.1_Missense_Mutation_p.S125R	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	959	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						ATGTTATAGAAGTTCAATGAC	0.358000												
NFE2L3	9603	broad.mit.edu	37	7	26224983	26224983	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:26224983C>T	uc003sxq.2	+	4	1937	c.1665C>T	c.(1663-1665)GTC>GTT	p.V555V		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	555					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						ATGAAATTGTCGGCATGCCTG	0.393000												
ABCA13	154664	broad.mit.edu	37	7	48559811	48559811	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:48559811T>A	uc003toq.2	+	53	13997	c.13972T>A	c.(13972-13974)TTC>ATC	p.F4658I	ABCA13_uc010kys.1_Missense_Mutation_p.F1733I|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.F388I	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4658	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GGGCTGGATCTTCGTGCAACT	0.502000												
STX1A	6804	broad.mit.edu	37	7	73122931	73122931	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:73122931T>G	uc003tyx.2	-	3	223	c.196A>C	c.(196-198)AAC>CAC	p.N66H	STX1A_uc003tyy.2_Missense_Mutation_p.N66H|STX1A_uc010lbj.1_Missense_Mutation_p.N66H|hsa-mir-4284|MI0015893_5'Flank	NM_004603	NP_004594	Q16623	STX1A_HUMAN	syntaxin 1A isoform 1	66	Cytoplasmic (Potential).				energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				TCATCGGGGTTGGGGGATGCC	0.637000												
PCLO	27445	broad.mit.edu	37	7	82544655	82544655	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:82544655T>G	uc003uhx.2	-	7	12936	c.12647A>C	c.(12646-12648)TAT>TCT	p.Y4216S	PCLO_uc003uhv.2_Missense_Mutation_p.Y4216S|PCLO_uc010lec.2_Missense_Mutation_p.Y1181S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4147					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATAGCTTGAATAATCAGGTTC	0.358000												
PCLO	27445	broad.mit.edu	37	7	82544697	82544697	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:82544697T>A	uc003uhx.2	-	7	12894	c.12605A>T	c.(12604-12606)AAA>ATA	p.K4202I	PCLO_uc003uhv.2_Missense_Mutation_p.K4202I|PCLO_uc010lec.2_Missense_Mutation_p.K1167I	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4133					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGGTGAAAATTTTGACATTTT	0.383000												
PCLO	27445	broad.mit.edu	37	7	82581838	82581838	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:82581838C>T	uc003uhx.2	-	5	8720	c.8431G>A	c.(8431-8433)GAA>AAA	p.E2811K	PCLO_uc003uhv.2_Missense_Mutation_p.E2811K|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2742					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTAGGCTTTCTGTGCCTGTA	0.473000												
SAMD9	54809	broad.mit.edu	37	7	92733880	92733880	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:92733880T>G	uc003umf.2	-	3	1787	c.1531A>C	c.(1531-1533)AGT>CGT	p.S511R	SAMD9_uc003umg.2_Missense_Mutation_p.S511R	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	511						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TGCCAGGAACTTGGATCAAAG	0.388000												
SGCE	8910	broad.mit.edu	37	7	94257572	94257572	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:94257572T>C	uc003unl.2	-	3	443	c.332A>G	c.(331-333)GAT>GGT	p.D111G	SGCE_uc003unm.2_Missense_Mutation_p.D111G|SGCE_uc003unn.2_Missense_Mutation_p.D111G|SGCE_uc011kic.1_Missense_Mutation_p.D70G|SGCE_uc011kid.1_Missense_Mutation_p.D147G	NM_003919	NP_003910	O43556	SGCE_HUMAN	sarcoglycan, epsilon isoform 2	111	Extracellular (Potential).				cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TAGGACTCCATCACTATATGG	0.388000												
DYNC1I1	1780	broad.mit.edu	37	7	95709704	95709704	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:95709704G>A	uc003uoc.3	+	16	2008	c.1731G>A	c.(1729-1731)GGG>GGA	p.G577G	DYNC1I1_uc003uod.3_Silent_p.G560G|DYNC1I1_uc003uob.2_Silent_p.G540G|DYNC1I1_uc003uoe.3_Silent_p.G557G|DYNC1I1_uc010lfl.2_Silent_p.G566G	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	577	WD 7.				vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CCATTGAGGGGGCATCCGCCC	0.453000												
RELN	5649	broad.mit.edu	37	7	103322678	103322678	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:103322678A>G	uc003vca.2	-	11	1334	c.1174T>C	c.(1174-1176)TAT>CAT	p.Y392H	RELN_uc010liz.2_Missense_Mutation_p.Y392H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	392					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCATGGAAATAAATGGAGTTC	0.433000												
C7orf58	79974	broad.mit.edu	37	7	120770266	120770266	+	Silent	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:120770266C>T	uc003vjq.3	+	12	1942	c.1495C>T	c.(1495-1497)CTG>TTG	p.L499L	C7orf58_uc003vjr.1_Silent_p.L499L|C7orf58_uc003vjs.3_Silent_p.L499L|C7orf58_uc003vjt.3_Silent_p.L279L|C7orf58_uc010lkk.1_Silent_p.L279L	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	499						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TGGCTCAGTCCTGACCCAATA	0.403000												
C7orf58	79974	broad.mit.edu	37	7	120781020	120781020	+	Silent	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:120781020T>C	uc003vjq.3	+	15	2286	c.1839T>C	c.(1837-1839)ACT>ACC	p.T613T	C7orf58_uc003vjs.3_Silent_p.T613T|C7orf58_uc003vjt.3_Silent_p.T393T	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	613						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GAGTGGAAACTCCTAAGTGTC	0.443000												
C7orf58	79974	broad.mit.edu	37	7	120876819	120876819	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:120876819T>C	uc003vjq.3	+	17	2554	c.2107T>C	c.(2107-2109)TCT>CCT	p.S703P	C7orf58_uc003vjs.3_Missense_Mutation_p.S703P|C7orf58_uc003vjt.3_Missense_Mutation_p.S483P	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	703						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					ACAGCCTATTTCTTCTGACTA	0.358000												
ABCF2	10061	broad.mit.edu	37	7	150920882	150920882	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:150920882C>T	uc003wjp.2	-	5	715	c.604G>A	c.(604-606)GAC>AAC	p.D202N	ABCF2_uc003wjo.1_Missense_Mutation_p.D202N	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	202	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCTGCCTTGTCGGCATCCAGC	0.592000												
UBE3C	9690	broad.mit.edu	37	7	157000610	157000610	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr7:157000610G>A	uc010lqs.2	+	13	2102	c.1790G>A	c.(1789-1791)AGA>AAA	p.R597K	UBE3C_uc003wng.2_Missense_Mutation_p.R597K	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	597					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		GAACAGAAAAGATGGATTCAG	0.328000												
UNC5D	137970	broad.mit.edu	37	8	35541239	35541239	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:35541239G>A	uc003xjr.1	+	5	1073	c.745G>A	c.(745-747)GTC>ATC	p.V249I	UNC5D_uc003xjs.1_Missense_Mutation_p.V244I|UNC5D_uc003xjt.1_Missense_Mutation_p.V18I	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	249	Extracellular (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CACTGTTGTGGTCTACGGTAA	0.512000												
IDO2	169355	broad.mit.edu	37	8	39871157	39871157	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:39871157G>A	uc010lwy.1	+	10	1074	c.832G>A	c.(832-834)GGC>AGC	p.G278S	IDO2_uc003xno.1_RNA|IDO2_uc010lwz.1_Missense_Mutation_p.G19S|IDO2_uc003xnp.1_Missense_Mutation_p.G19S	NM_194294	NP_919270	Q6ZQW0	I23O2_HUMAN	indoleamine-pyrrole 2,3 dioxygenase-like 1	265					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			ovary(2)	2						GAAATACTCCGGCGGGAGTGC	0.478000												
MYST3	7994	broad.mit.edu	37	8	41906165	41906165	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:41906165C>A	uc010lxb.2	-	3	875	c.331G>T	c.(331-333)GCA>TCA	p.A111S	MYST3_uc010lxc.2_Missense_Mutation_p.A111S|MYST3_uc003xon.3_Missense_Mutation_p.A111S|MYST3_uc010lxd.2_Missense_Mutation_p.A111S	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	111	H15.|Required for activation of RUNX1-1.|Required for nuclear localization.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			CCAGACTCTGCCAAGCCCTCA	0.448000												
PXDNL	137902	broad.mit.edu	37	8	52384785	52384785	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:52384785T>G	uc003xqu.3	-	8	875	c.774A>C	c.(772-774)GAA>GAC	p.E258D		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	258	Ig-like C2-type 1.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGGGGTTTCCTTCCGCCCGGC	0.443000												
TTPA	7274	broad.mit.edu	37	8	63976767	63976767	+	Missense_Mutation	SNP	G	G	A	rs35916840	byFrequency	TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:63976767G>A	uc003xux.1	-	4	693	c.661C>T	c.(661-663)CGG>TGG	p.R221W		NM_000370	NP_000361	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	221	CRAL-TRIO.				lipid metabolic process		transporter activity|vitamin E binding				0	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	TTACTCACCCGTTCCTTAATT	0.368000												
POP1	10940	broad.mit.edu	37	8	99170065	99170065	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:99170065G>A	uc003yij.3	+	16	2741	c.2641G>A	c.(2641-2643)GAG>AAG	p.E881K	POP1_uc011lgv.1_Missense_Mutation_p.E881K|POP1_uc003yik.2_Missense_Mutation_p.E881K	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	881					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			CCCAGCCAAGGAGGACTTCCT	0.552000												
TM7SF4	81501	broad.mit.edu	37	8	105361682	105361682	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:105361682T>G	uc003ylx.1	+	2	951	c.902T>G	c.(901-903)CTT>CGT	p.L301R		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	301	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTCCCCATACTTATCCATCTC	0.473000												
KCNV1	27012	broad.mit.edu	37	8	110986309	110986309	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:110986309G>A	uc003ynr.3	-	1	651	c.309C>T	c.(307-309)TTC>TTT	p.F103F	KCNV1_uc010mcw.2_Silent_p.F103F	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	103	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			AGCTGCGGTCGAAGAAGTACT	0.662000												
KCNQ3	3786	broad.mit.edu	37	8	133187703	133187703	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:133187703G>A	uc003ytj.2	-	5	1155	c.930C>T	c.(928-930)GGC>GGT	p.G310G	KCNQ3_uc010mdt.2_Silent_p.G310G	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	310			G -> V (in EBN2; about 50% reduction of wild-type heteromeric current; ratio of 1:1; or 20%; ratio of 1:1:2).		axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GACTCACCAGGCCCCACCACA	0.527000												
ARHGAP39	80728	broad.mit.edu	37	8	145772550	145772550	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:145772550G>A	uc003zdt.1	-	6	2475	c.1920C>T	c.(1918-1920)ACC>ACT	p.T640T	ARHGAP39_uc011llk.1_Silent_p.T640T|ARHGAP39_uc003zds.1_Silent_p.T640T	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	640					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						AGGCCAGGTTGGTCTGCACGG	0.657000												
NPR2	4882	broad.mit.edu	37	9	35800105	35800105	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr9:35800105G>A	uc003zyd.2	+	4	1074	c.1074G>A	c.(1072-1074)CGG>CGA	p.R358R	NPR2_uc010mlb.2_Silent_p.R358R	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	358	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	GAGGCACCCGGGAGGATGGAC	0.512000												
C9orf102	375748	broad.mit.edu	37	9	98685633	98685633	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr9:98685633C>G	uc004avt.3	+	9	1926	c.1538C>G	c.(1537-1539)TCT>TGT	p.S513C	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Missense_Mutation_p.S215C|C9orf102_uc010mry.1_Missense_Mutation_p.S215C|C9orf102_uc010mrz.2_Missense_Mutation_p.S324C|C9orf102_uc004avu.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	513					DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				GAAACACTTTCTGACCCTAAA	0.303000												
GARNL3	84253	broad.mit.edu	37	9	130147318	130147318	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr9:130147318C>T	uc011mae.1	+	24	2683	c.2282C>T	c.(2281-2283)CCG>CTG	p.P761L	GARNL3_uc011mad.1_Missense_Mutation_p.P739L|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	761	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TGTGCTTTCCCGTATCTCCTG	0.617000												
FUBP3	8939	broad.mit.edu	37	9	133498194	133498194	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr9:133498194C>T	uc004bzr.1	+	10	979	c.871C>T	c.(871-873)CCA>TCA	p.P291S	FUBP3_uc010mzd.1_Missense_Mutation_p.P231S|FUBP3_uc004bzs.1_Missense_Mutation_p.P204S	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	291	KH 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		TCAGTTTAAACCAGGTGGGTA	0.368000												
RPS6KA3	6197	broad.mit.edu	37	X	20173605	20173605	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:20173605G>A	uc004czu.2	-	22	2134	c.2134C>T	c.(2134-2136)CGT>TGT	p.R712C	RPS6KA3_uc011mjk.1_Missense_Mutation_p.R682C|RPS6KA3_uc004czv.2_Missense_Mutation_p.R699C|RPS6KA3_uc011mjl.1_Missense_Mutation_p.R683C|RPS6KA3_uc011mjm.1_Missense_Mutation_p.R684C	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	712					axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						GACTGATTACGGTTCAAAGCA	0.433000												
ZNF645	158506	broad.mit.edu	37	X	22292314	22292314	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:22292314G>A	uc004dai.1	+	1	1255	c.1206G>A	c.(1204-1206)ACG>ACA	p.T402T		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	402						intracellular	zinc ion binding			lung(1)|pancreas(1)	2						GTCCACCAACGCGGAGTCCAC	0.458000												
FAM47C	442444	broad.mit.edu	37	X	37028374	37028374	+	Missense_Mutation	SNP	C	C	T	rs140469750	byFrequency	TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:37028374C>T	uc004ddl.1	+	1	1905	c.1891C>T	c.(1891-1893)CGC>TGC	p.R631C		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	631										ovary(3)	3						GTCCCATCTCCGCCCAGAGCC	0.637000												
RBM10	8241	broad.mit.edu	37	X	47030564	47030564	+	Silent	SNP	G	G	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:47030564G>A	uc004dhf.2	+	4	718	c.339G>A	c.(337-339)GAG>GAA	p.E113E	RBM10_uc004dhe.1_Silent_p.E103E|RBM10_uc004dhg.2_Intron|RBM10_uc004dhh.2_Silent_p.E113E|RBM10_uc010nhq.2_Intron|RBM10_uc004dhi.2_Silent_p.E178E	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	113	Poly-Glu.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						AGCAAGGggaggaggaggagg	0.522000												
WNK3	65267	broad.mit.edu	37	X	54228489	54228489	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:54228489T>G	uc004dtd.1	-	22	5276	c.4837A>C	c.(4837-4839)AGT>CGT	p.S1613R	WNK3_uc004dtc.1_Missense_Mutation_p.S1670R	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1613					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TGGTTTAAACTTGGCTTAATA	0.363000												
MAGEE1	57692	broad.mit.edu	37	X	75648562	75648562	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:75648562T>G	uc004ecm.1	+	1	446	c.239T>G	c.(238-240)GTG>GGG	p.V80G		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	80						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						AGCACCTTTGTGCCGCCCACC	0.682000												
ZCCHC16	340595	broad.mit.edu	37	X	111698082	111698082	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:111698082A>C	uc004epo.1	+	3	567	c.126A>C	c.(124-126)CAA>CAC	p.Q42H		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	42							nucleic acid binding|zinc ion binding			ovary(1)	1						AAAGGGGCCAAGTCATGCCTG	0.522000												
VGLL1	51442	broad.mit.edu	37	X	135638646	135638646	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:135638646T>G	uc004ezy.2	+	5	895	c.725T>G	c.(724-726)CTT>CGT	p.L242R		NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)					AAATACTCACTTACACCACCA	0.478000												
UBE2NL	389898	broad.mit.edu	37	X	142967519	142967519	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:142967519T>C	uc004fca.2	+	1	347	c.317T>C	c.(316-318)CTG>CCG	p.L106P		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	106							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					CGCACAGTTCTGCTATCGATC	0.423000												
MAGEA12	4111	broad.mit.edu	37	X	151896589	151896589	+	RNA	SNP	C	C	A			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:151896589C>A	uc004fgb.2	-	3		c.388G>T						P43365	MAGAC_HUMAN	Homo sapiens melanoma antigen family A, 12, mRNA (cDNA clone MGC:4914 IMAGE:3450217), complete cds.											skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTGTTGGACAATGGGCTGG	0.557000												
HDAC7	51564	broad.mit.edu	37	12	48192633	48192633	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr12:48192633delG	uc009zkv.1	-	1	291	c.76delC	c.(76-78)CAGfs	p.Q26fs	HDAC7_uc010slo.1_Frame_Shift_Del_p.Q65fs|HDAC7_uc001rqj.3_Frame_Shift_Del_p.Q65fs|HDAC7_uc001rqk.3_Frame_Shift_Del_p.Q48fs			Q8WUI4	HDAC7_HUMAN	Synthetic construct DNA, clone: pF1KB0470, Homo sapiens HDAC7 gene for histone deacetylase 7, without stop codon, in Flexi system.	26	Transcription repression 1 (By similarity).|Interaction with MEF2C (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		TGCAGGCGCTGGGGACGCTGC	0.692												
ITGB4	3691	broad.mit.edu	37	17	73747111	73747112	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr17:73747111_73747112insT	uc002jpg.2	+	30	3899_3900	c.3712_3713insT	c.(3712-3714)CTGfs	p.L1238fs	ITGB4_uc002jph.2_Frame_Shift_Ins_p.L1238fs|ITGB4_uc002jpi.3_Frame_Shift_Ins_p.L1238fs|ITGB4_uc002jpj.2_Frame_Shift_Ins_p.L1238fs	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	1238	Fibronectin type-III 2.|Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGTGACCCAGCTGAGCTGGGCT	0.594												
OBSCN	84033	broad.mit.edu	37	1	228434288	228434289	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr1:228434287_228434288A>AG	uc009xez.1	+	12	3860_3861	c.3816_3817A>AG	c.(3814-3819)gcagggfs	p.A1272fs	OBSCN_uc001hsn.3_Frame_Shift_Ins_p.A1272fs	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	1272	Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	M band|Z disc|cytosol	ATP binding|Rho guanyl-nucleotide exchange factor activity|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of muscle|titin binding	p.E1271E(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGACTGAGGCAGGGGCCAGTGC	0.584												
ZNF804A	91752	broad.mit.edu	37	2	185803431	185803458	+	Frame_Shift_Del	DEL	TGCAGCAGCACGCTGCAGCTGCTGCAGC	TGCAGCAGCACGCTGCAGCTGCTGCAGC	-	rs112183442	byFrequency	TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr2:185803430_185803457TTGCAGCAGCACGCTGCAGCTGCTGCAGC>T	uc002uph.3	+	3	3901_3928	c.3307_3334TTGCAGCAGCACGCTGCAGCTGCTGCAGC>T	c.(3307-3336)ttgcagcagcacgctgcagctgctgcagctfs	p.L1103fs		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	Homo sapiens zinc finger protein 804A (ZNF804A), mRNA.	1103						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TCACACTGTTTtgcagcagcacgctgcagctgctgcagctgcagctgc	0.544												
ELP3	55140	broad.mit.edu	37	8	27967928	27967929	+	Frame_Shift_Ins	INS	-	-	CCTA			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr8:27967927_27967928T>TCCTA	uc003xgo.4	+	5	582_583	c.434_435T>TCCTA	c.(433-435)ttcfs	p.F145fs	ELP3_uc003xgn.4_Frame_Shift_Ins_p.F130fs|ELP3_uc011las.2_Frame_Shift_Ins_p.F26fs|ELP3_uc011lat.2_Frame_Shift_Ins_p.F26fs|ELP3_uc011laq.2_Frame_Shift_Ins_p.F73fs|ELP3_uc011lar.2_Frame_Shift_Ins_p.F53fs	NM_018091	NP_060561	Q9H9T3	ELP3_HUMAN	Homo sapiens elongation protein 3 homolog (S. cerevisiae) (ELP3), mRNA.	145					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	DNA-directed RNA polymerase II, holoenzyme|cytoplasm|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		TATGACCCTTTCCTACAGACAA	0.337												
AOC3	8639	broad.mit.edu	37	17	41003597	41003598	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr17:41003596_41003597T>TG	uc002ibv.3	+	0	396_397	c.236_237T>TG	c.(235-237)ctgfs	p.L79fs		NM_003734	NP_003725	Q16853	AOC3_HUMAN	Homo sapiens amine oxidase, copper containing 3 (vascular adhesion protein 1) (AOC3), mRNA.	79					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	ACCCAGCGGCTGGGGCCAGGGC	0.658												
ITGB4	3691	broad.mit.edu	37	17	73747112	73747113	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr17:73747111_73747112C>CT	uc002jpg.3	+	29	3899_3900	c.3712_3713C>CT	c.(3712-3714)ctgfs	p.L1238fs	ITGB4_uc002jph.3_Frame_Shift_Ins_p.L1238fs|ITGB4_uc002jpi.4_Frame_Shift_Ins_p.L1238fs|ITGB4_uc002jpj.3_Frame_Shift_Ins_p.L1238fs	NM_000213	NP_000204	P16144	ITB4_HUMAN	Homo sapiens integrin, beta 4 (ITGB4), transcript variant 1, mRNA.	1238	Fibronectin type-III 2.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGTGACCCAGCTGAGCTGGGCT	0.594												
FHOD3	80206	broad.mit.edu	37	18	34298328	34298329	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chr18:34298327_34298328T>TCC	uc021uiv.1	+	18	3163_3164	c.3066_3067T>TCC	c.(3064-3069)cctcccfs	p.P1022fs	FHOD3_uc002kzs.1_Frame_Shift_Ins_p.P847fs|FHOD3_uc002kzt.1_Frame_Shift_Ins_p.P830fs|FHOD3_uc010dmz.1_Frame_Shift_Ins_p.P562fs|FHOD3_uc010dna.1_Frame_Shift_Ins_p.P150fs	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	Homo sapiens formin homology 2 domain containing 3 (FHOD3), mRNA.	830	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CTGGGCCACCTCCCCCACCCCC	0.604												
PPP2R3B	28227	broad.mit.edu	37	X	301618	301624	+	Frame_Shift_Del	DEL	GAACATG	GAACATG	-	rs147635089	byFrequency	TCGA-BR-7197-01A-11D-2201-08	TCGA-BR-7197-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ce737023-df0f-4b98-a1bf-695c7ef3ea71	08979d3a-4c9d-4d8b-b6f4-aadd58ae0ccc	g.chrX:301617_301623CGAACATG>C	uc004cpg.3	-	9	1492_1498	c.1228_1234CATGTTCG>G	c.(1228-1236)atgttcgagfs	p.M410fs	PPP2R3B_uc004cpf.3_Frame_Shift_Del_p.M11fs	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	Homo sapiens protein phosphatase 2, regulatory subunit B'', beta (PPP2R3B), mRNA.	410	EF-hand.				cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TACTCGAGCTCGAACATGGACAGGGCG	0.662