Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
AGRN	375790	broad.mit.edu	37	1	979010	979010	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:979010G>A	uc001ack.1	+	9	1746	c.1696G>A	c.(1696-1698)GTG>ATG	p.V566M		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	566	Kazal-like 6.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GGCCCAGCCCGTGTGTGGCTC	0.692000												
PER3	8863	broad.mit.edu	37	1	7887631	7887631	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:7887631C>T	uc001aoo.2	+	17	2793	c.2618C>T	c.(2617-2619)GCG>GTG	p.A873V	PER3_uc009vmg.1_Missense_Mutation_p.A881V|PER3_uc009vmh.1_Missense_Mutation_p.A874V|PER3_uc001aop.2_Missense_Mutation_p.A881V|PER3_uc010nzw.1_Missense_Mutation_p.A562V	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	873	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCTGGGGGCGACAGCCTCT	0.527000												
TNFRSF9	3604	broad.mit.edu	37	1	7995117	7995117	+	Missense_Mutation	SNP	G	G	A	rs145966863	byFrequency	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:7995117G>A	uc001aot.2	-	6	628	c.500C>T	c.(499-501)CCG>CTG	p.P167L		NM_001561	NP_001552	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily,	167	Extracellular (Potential).				induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		GGATGCTCCCGGAGAGAGGTC	0.542000												
ARHGEF10L	55160	broad.mit.edu	37	1	17952451	17952451	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:17952451C>T	uc001ban.2	+	14	1477	c.1318C>T	c.(1318-1320)CGA>TGA	p.R440*	ARHGEF10L_uc009vpe.1_Nonsense_Mutation_p.R401*|ARHGEF10L_uc001bao.2_Nonsense_Mutation_p.R401*|ARHGEF10L_uc001bap.2_Nonsense_Mutation_p.R401*|ARHGEF10L_uc010ocr.1_Nonsense_Mutation_p.R198*|ARHGEF10L_uc001baq.2_Nonsense_Mutation_p.R206*|ARHGEF10L_uc010ocs.1_Nonsense_Mutation_p.R218*|ARHGEF10L_uc001bar.2_Intron|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	440	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		TCTCCACCAGCGACGGCAGGT	0.617000												
MRTO4	51154	broad.mit.edu	37	1	19583994	19583994	+	Missense_Mutation	SNP	G	G	A	rs114437725	byFrequency	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:19583994G>A	uc001bbs.2	+	5	575	c.320G>A	c.(319-321)CGC>CAC	p.R107H		NM_016183	NP_057267	Q9UKD2	MRT4_HUMAN	mRNA turnover 4 homolog	107					ribosome biogenesis	nuclear membrane|nucleolus					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.87e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00301)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TTCACCAACCGCACAAAGGAG	0.488000												
HSPG2	3339	broad.mit.edu	37	1	22160079	22160079	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:22160079C>T	uc001bfj.2	-	79	10899	c.10859G>A	c.(10858-10860)CGC>CAC	p.R3620H	HSPG2_uc001bfi.2_5'Flank|HSPG2_uc009vqd.2_Missense_Mutation_p.R3621H	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3620	Ig-like C2-type 22.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GTTCTCCAGGCGGCTGTCAGG	0.637000												
ZBTB40	9923	broad.mit.edu	37	1	22848916	22848916	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:22848916G>A	uc001bft.2	+	17	3769	c.3258G>A	c.(3256-3258)ACG>ACA	p.T1086T	ZBTB40_uc001bfu.2_Silent_p.T1086T|ZBTB40_uc009vqi.1_Silent_p.T974T	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	1086	C2H2-type 10.				bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TCTTCCCCACGCCAGCCTTGC	0.403000												
EXTL1	2134	broad.mit.edu	37	1	26360246	26360246	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:26360246G>A	uc001blf.2	+	9	2445	c.1578G>A	c.(1576-1578)ACG>ACA	p.T526T		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	526	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		GCTTCCTGACGTCGAGCCATT	0.582000												
CATSPER4	378807	broad.mit.edu	37	1	26524487	26524487	+	Silent	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:26524487C>A	uc010oez.1	+	5	597	c.597C>A	c.(595-597)CCC>CCA	p.P199P	CATSPER4_uc010oey.1_Silent_p.P21P|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	199	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		CGGTGGAGCCCCTCGCCCGGA	0.637000												
ARID1A	8289	broad.mit.edu	37	1	27099008	27099008	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:27099008C>T	uc001bmv.1	+	13	3797	c.3424C>T	c.(3424-3426)CAG>TAG	p.Q1142*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1142*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1142*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q759*|ARID1A_uc001bmx.1_5'UTR|ARID1A_uc009vsm.1_5'Flank|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1142					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGGATCTATGCAGGGGCCCCA	0.527000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
ARID1A	8289	broad.mit.edu	37	1	27106861	27106861	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:27106861C>T	uc001bmv.1	+	20	6845	c.6472C>T	c.(6472-6474)CGA>TGA	p.R2158*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.R1941*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.R1004*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.R486*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.R400*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2158					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.R2158*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTCAGTGACCGAAAGAACCC	0.597000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
FAM46B	115572	broad.mit.edu	37	1	27332693	27332693	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:27332693G>A	uc010ofj.1	-	2	1192	c.1020C>T	c.(1018-1020)TAC>TAT	p.Y340Y		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	340										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		CCAGGCAGGCGTAACGGCGGG	0.662000												
TAF12	6883	broad.mit.edu	37	1	28948573	28948573	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:28948573T>C	uc001bqw.2	-	1	114	c.21A>G	c.(19-21)TCA>TCG	p.S7S	TAF12_uc001bqx.2_Silent_p.S7S|TAF12_uc001bqy.2_Silent_p.S7S|TAF12_uc009vti.2_Silent_p.S7S	NM_005644	NP_005635	Q16514	TAF12_HUMAN	TAF12 RNA polymerase II, TATA box binding	7					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Renal(390;0.00121)|Breast(348;0.00502)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)		Colorectal(126;3.21e-08)|COAD - Colon adenocarcinoma(152;1.74e-06)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(1967;0.0109)|BRCA - Breast invasive adenocarcinoma(304;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		TGATTAGGGCTGAGGGGCCAA	0.493000												
NKAIN1	79570	broad.mit.edu	37	1	31655387	31655387	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:31655387C>A	uc010ogd.1	-	5	528	c.522G>T	c.(520-522)GAG>GAT	p.E174D	NKAIN1_uc001bsn.2_Missense_Mutation_p.E130D|NKAIN1_uc010ogc.1_Missense_Mutation_p.E103D	NM_024522	NP_078798	Q4KMZ8	NKAI1_HUMAN	Na+/K+ transporting ATPase interacting 1	174	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|Breast(348;0.141)|all_neural(195;0.146)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0184)|READ - Rectum adenocarcinoma(331;0.148)		AGCTGTCCTCCTCCTCCAGGA	0.632000												
RNF19B	127544	broad.mit.edu	37	1	33411121	33411121	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:33411121T>C	uc010oho.1	-	5	1258	c.1258A>G	c.(1258-1260)AGT>GGT	p.S420G	RNF19B_uc001bwm.3_Missense_Mutation_p.S419G|RNF19B_uc010ohp.1_Missense_Mutation_p.S419G	NM_153341	NP_699172	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B isoform a	420	Helical; (Potential).					integral to membrane	ligase activity|protein binding|zinc ion binding				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TTACCAACACTAACTGCAGCA	0.463000												
CSMD2	114784	broad.mit.edu	37	1	34554619	34554619	+	Silent	SNP	C	C	T	rs141030168		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:34554619C>T	uc001bxn.1	-	2	272	c.243G>A	c.(241-243)TCG>TCA	p.S81S	CSMD2_uc001bxm.1_Silent_p.S121S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	81	CUB 1.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CATCAAACACCGACAGGACAT	0.552000												
CCDC30	728621	broad.mit.edu	37	1	43119565	43119565	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:43119565G>A	uc009vwk.1	+	16	2328	c.2218G>A	c.(2218-2220)GCA>ACA	p.A740T	CCDC30_uc001chm.2_Missense_Mutation_p.A438T|CCDC30_uc001chn.2_Missense_Mutation_p.A529T	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	740											0						AGAAGCAATGGCAAGTTCAAA	0.413000												
IPO13	9670	broad.mit.edu	37	1	44426892	44426892	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:44426892T>A	uc001ckx.2	+	14	3097	c.2302T>A	c.(2302-2304)TTC>ATC	p.F768I		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	768					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TGAGGCCCTCTTCCTGCTCGT	0.592000												
CYP4Z1	199974	broad.mit.edu	37	1	47560306	47560306	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:47560306C>T	uc001cqu.1	+	7	844	c.841C>T	c.(841-843)CGC>TGC	p.R281C		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	281	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						TCAGAAAAGGCGCTGGGATTT	0.318000												
MYSM1	114803	broad.mit.edu	37	1	59132821	59132821	+	Silent	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:59132821G>T	uc009wab.1	-	16	1943	c.1920C>A	c.(1918-1920)GCC>GCA	p.A640A	MYSM1_uc009waa.1_Silent_p.A46A|MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	640	MPN.				histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					AGGTTTCTGAGGCCTGTGTTT	0.428000												
DNAJC6	9829	broad.mit.edu	37	1	65851439	65851439	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:65851439G>A	uc001dcd.1	+	7	838	c.674G>A	c.(673-675)CGC>CAC	p.R225H	DNAJC6_uc001dcc.1_Missense_Mutation_p.R256H|DNAJC6_uc010opc.1_Missense_Mutation_p.R212H|DNAJC6_uc001dce.1_Missense_Mutation_p.R282H	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	225					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						AAGCCCTACCGCCCTCACTTC	0.488000												
WDR78	79819	broad.mit.edu	37	1	67313177	67313177	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:67313177A>G	uc001dcx.2	-	8	1337	c.1281T>C	c.(1279-1281)CCT>CCC	p.P427P	WDR78_uc001dcy.2_Silent_p.P427P|WDR78_uc009waw.2_Silent_p.P173P|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	427										ovary(2)	2						CTTTTAAAACAGGAAGCTGAC	0.204000												
ABCA4	24	broad.mit.edu	37	1	94480241	94480241	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:94480241G>A	uc001dqh.2	-	38	5422	c.5318C>T	c.(5317-5319)GCG>GTG	p.A1773V	ABCA4_uc009wdp.1_Missense_Mutation_p.A41V	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1773	Helical; (Potential).				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGGAATGACCGCCCATCTGTG	0.478000												
NTNG1	22854	broad.mit.edu	37	1	107867388	107867388	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:107867388A>G	uc001dvh.3	+	3	1449	c.731A>G	c.(730-732)TAC>TGC	p.Y244C	NTNG1_uc001dvf.3_Missense_Mutation_p.Y244C|NTNG1_uc010out.1_Missense_Mutation_p.Y244C|NTNG1_uc001dvc.3_Missense_Mutation_p.Y244C|NTNG1_uc001dvd.1_Missense_Mutation_p.Y244C	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	244	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GCTTCCCTCTACGGACAGCTG	0.428000												
VAV3	10451	broad.mit.edu	37	1	108417623	108417623	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:108417623T>C	uc001dvk.1	-	2	275	c.221A>G	c.(220-222)AAC>AGC	p.N74S	VAV3_uc010ouw.1_Missense_Mutation_p.N74S|VAV3_uc001dvl.1_5'UTR|VAV3_uc010oux.1_Missense_Mutation_p.N74S	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	74	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TGTCCTTATGTTCTTCAAACA	0.393000												
AMPD2	271	broad.mit.edu	37	1	110168017	110168017	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:110168017C>T	uc009wfh.1	+	3	888	c.346C>T	c.(346-348)CGC>TGC	p.R116C	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Missense_Mutation_p.R35C|AMPD2_uc001dyc.1_Missense_Mutation_p.R116C|AMPD2_uc010ovr.1_Intron|AMPD2_uc010ovs.1_5'UTR|AMPD2_uc001dyd.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	116					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		GCTCGACCTGCGCACGTCTAT	0.687000												
KCND3	3752	broad.mit.edu	37	1	112318756	112318756	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:112318756G>A	uc001ebu.1	-	8	2391	c.1911C>T	c.(1909-1911)GGC>GGT	p.G637G	KCND3_uc001ebv.1_Silent_p.G618G	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	637	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TCGTGTTGGGGCCTGGGCTGG	0.582000												
PTGFRN	5738	broad.mit.edu	37	1	117509774	117509774	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:117509774C>T	uc001egv.1	+	6	2018	c.1881C>T	c.(1879-1881)GGC>GGT	p.G627G		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	627	Ig-like C2-type 5.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GGGTGGATGGCGTTGTTTTAG	0.522000												
MAN1A2	10905	broad.mit.edu	37	1	117944904	117944904	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:117944904T>C	uc001ehd.1	+	2	1120	c.399T>C	c.(397-399)ATT>ATC	p.I133I	MAN1A2_uc009whg.1_Intron	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	133	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		GAGAGGAAATTCGAGCAGAAA	0.398000												
THEM4	117145	broad.mit.edu	37	1	151849482	151849482	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:151849482G>A	uc001ezj.1	-	5	856	c.677C>T	c.(676-678)GCG>GTG	p.A226V	THEM4_uc001ezk.1_RNA	NM_053055	NP_444283	Q5T1C6	THEM4_HUMAN	thioesterase superfamily member 4	226					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|ruffle membrane					0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTTACTTGTCGCCTCTGAGTA	0.353000												
FLG	2312	broad.mit.edu	37	1	152283959	152283959	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:152283959T>C	uc001ezu.1	-	3	3439	c.3403A>G	c.(3403-3405)AGG>GGG	p.R1135G	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1135	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGCTGGTCCTGGTCCGCCCA	0.597000									Ichthyosis			
FLG	2312	broad.mit.edu	37	1	152284170	152284170	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:152284170C>T	uc001ezu.1	-	3	3228	c.3192G>A	c.(3190-3192)TGG>TGA	p.W1064*	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1064	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACTGGACCCCCAGTGTCCAC	0.572000									Ichthyosis			
FLG	2312	broad.mit.edu	37	1	152284172	152284172	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:152284172A>G	uc001ezu.1	-	3	3226	c.3190T>C	c.(3190-3192)TGG>CGG	p.W1064R	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1064	Filaggrin 6.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGACCCCCAGTGTCCACTG	0.572000									Ichthyosis			
FCRL5	83416	broad.mit.edu	37	1	157497672	157497672	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:157497672G>A	uc001fqu.2	-	9	1853	c.1695C>T	c.(1693-1695)CGC>CGT	p.R565R	FCRL5_uc009wsm.2_Silent_p.R565R|FCRL5_uc010phv.1_Silent_p.R565R|FCRL5_uc010phw.1_Silent_p.R480R	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	565	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity	p.R565H(1)		ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TGAGGATGGGGCGAGACACTG	0.458000												
OR10Z1	128368	broad.mit.edu	37	1	158576516	158576516	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:158576516C>T	uc010pio.1	+	1	288	c.288C>T	c.(286-288)GGC>GGT	p.G96G		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CCTATGTGGGCTGTGCTGCCC	0.542000												
ADAMTS4	9507	broad.mit.edu	37	1	161163166	161163166	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:161163166C>T	uc001fyt.3	-	7	2176	c.1748G>A	c.(1747-1749)CGC>CAC	p.R583H		NM_005099	NP_005090	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1	583	Cys-rich.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			ovary(4)|central_nervous_system(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CTGCTCCTCGCGGAAGGTCAG	0.617000												
RASAL2	9462	broad.mit.edu	37	1	178411966	178411966	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:178411966G>A	uc001glr.2	+	6	765	c.640G>A	c.(640-642)GAA>AAA	p.E214K	RASAL2_uc001glq.2_Missense_Mutation_p.E362K	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	214	C2.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						TTTCTGGGGCGAACATTTTGA	0.383000												
QSOX1	5768	broad.mit.edu	37	1	180135652	180135652	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:180135652G>A	uc001gnz.2	+	2	367	c.292G>A	c.(292-294)GCC>ACC	p.A98T	QSOX1_uc001gny.2_Missense_Mutation_p.A98T|QSOX1_uc001goa.2_Missense_Mutation_p.A98T	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	98	Thioredoxin.				cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						GTATCTCGCCGCCCTGGACTG	0.597000												
PRG4	10216	broad.mit.edu	37	1	186280649	186280649	+	Silent	SNP	A	A	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:186280649A>T	uc001gru.3	+	10	3765	c.3714A>T	c.(3712-3714)GGA>GGT	p.G1238G	PRG4_uc001grt.3_Silent_p.G1197G|PRG4_uc009wyl.2_Silent_p.G1145G|PRG4_uc009wym.2_Silent_p.G1104G|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1238	Hemopexin-like 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GATTTGGAGGACTAACTGGAC	0.358000												
F13B	2165	broad.mit.edu	37	1	197009701	197009701	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:197009701G>A	uc001gtt.1	-	11	1947	c.1903C>T	c.(1903-1905)CAA>TAA	p.Q635*		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	635	Sushi 10.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CTGTCACATTGCATTCTAAGT	0.308000												
PPFIA4	8497	broad.mit.edu	37	1	203026010	203026010	+	Missense_Mutation	SNP	G	G	A	rs142427146	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:203026010G>A	uc001gyz.2	+	6	1414	c.821G>A	c.(820-822)GGC>GAC	p.G274D	PPFIA4_uc009xaj.2_Missense_Mutation_p.G905D|PPFIA4_uc010pqf.1_Missense_Mutation_p.G487D|PPFIA4_uc001gza.2_Missense_Mutation_p.G274D|PPFIA4_uc001gzb.1_5'UTR	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	274					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						TCGTCCATTGGCCGCCTGTTT	0.622000												
ZC3H11A	9877	broad.mit.edu	37	1	203798733	203798733	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:203798733G>A	uc001hac.2	+	8	1069	c.453G>A	c.(451-453)ACG>ACA	p.T151T	ZC3H11A_uc001had.2_Silent_p.T151T|ZC3H11A_uc001hae.2_Silent_p.T151T|ZC3H11A_uc001haf.2_Silent_p.T151T|ZC3H11A_uc010pqm.1_Silent_p.T97T|ZC3H11A_uc001hag.1_Silent_p.T151T	NM_014827	NP_055642	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	151							nucleic acid binding|protein binding|zinc ion binding			lung(1)|central_nervous_system(1)	2	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CTAGCCCCACGCATCCACCAG	0.433000												
CR1	1378	broad.mit.edu	37	1	207737304	207737304	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:207737304C>T	uc001hfy.2	+	14	2472	c.2332C>T	c.(2332-2334)CCC>TCC	p.P778S	CR1_uc009xcl.1_Intron|CR1_uc001hfx.2_Missense_Mutation_p.P1228S|CR1_uc009xck.1_Intron	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	778	Sushi 12.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CAGCTGTGAGCCCGGCTATGA	0.582000												
SERTAD4	56256	broad.mit.edu	37	1	210415495	210415495	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:210415495G>A	uc001hhy.2	+	4	1063	c.884G>A	c.(883-885)GGC>GAC	p.G295D	SERTAD4_uc009xcw.2_Missense_Mutation_p.G295D	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	295							protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		AGAGATGGTGGCCCCCTCAGC	0.403000												
DTL	51514	broad.mit.edu	37	1	212220516	212220516	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:212220516G>A	uc009xdc.2	+	4	615	c.301G>A	c.(301-303)GTC>ATC	p.V101I	DTL_uc010ptb.1_Missense_Mutation_p.V59I|DTL_uc001hiz.3_5'UTR	NM_016448	NP_057532	Q9NZJ0	DTL_HUMAN	denticleless homolog	101	WD 2.				DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		CTGGAATGCCGTCTTTGACCT	0.353000												
RYR2	6262	broad.mit.edu	37	1	237608710	237608710	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:237608710C>T	uc001hyl.1	+	14	1300	c.1180C>T	c.(1180-1182)CAT>TAT	p.H394Y		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	394	Cytoplasmic (By similarity).|MIR 5.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCTATTATGCATCATGAAGG	0.443000												
RYR2	6262	broad.mit.edu	37	1	237804199	237804199	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:237804199A>G	uc001hyl.1	+	47	7238	c.7118A>G	c.(7117-7119)GAC>GGC	p.D2373G		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2373	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CATGAAAGTGACACAGAGGAG	0.428000												
OR2T12	127064	broad.mit.edu	37	1	248458331	248458331	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:248458331G>A	uc010pzj.1	-	1	550	c.550C>T	c.(550-552)CGT>TGT	p.R184C		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CAAGCCAAACGCACCAACACG	0.552000												
OR2T34	127068	broad.mit.edu	37	1	248737709	248737709	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:248737709A>C	uc001iep.1	-	1	350	c.350T>G	c.(349-351)GTT>GGT	p.V117G		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAGGAGGAAAACCTCAGCTCC	0.567000												
DIP2C	22982	broad.mit.edu	37	10	435950	435950	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:435950C>A	uc001ifp.2	-	13	1668	c.1578G>T	c.(1576-1578)CAG>CAT	p.Q526H	DIP2C_uc009xhj.1_Missense_Mutation_p.Q222H	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	526						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		AGCCACACGCCTGCGTCAGGG	0.607000												
WDR37	22884	broad.mit.edu	37	10	1170951	1170951	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:1170951G>A	uc001igf.1	+	13	1513	c.1340G>A	c.(1339-1341)CGG>CAG	p.R447Q	WDR37_uc009xhm.1_Missense_Mutation_p.R448Q|WDR37_uc009xhn.1_RNA|WDR37_uc001igg.1_RNA	NM_014023	NP_054742	Q9Y2I8	WDR37_HUMAN	WD repeat domain 37	447											0		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		CGGCTTCCCCGGAGCAGCCGA	0.507000												
ITIH5	80760	broad.mit.edu	37	10	7608006	7608006	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:7608006G>A	uc001ijq.2	-	13	2593	c.2514C>T	c.(2512-2514)TGC>TGT	p.C838C	ITIH5_uc001ijp.2_Silent_p.C624C	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	838					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GCAGTCCGTGGCAGTTGCTGG	0.547000												
ITGA8	8516	broad.mit.edu	37	10	15726071	15726071	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:15726071G>T	uc001ioc.1	-	4	500	c.500C>A	c.(499-501)CCA>CAA	p.P167Q	ITGA8_uc010qcb.1_Missense_Mutation_p.P167Q	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	167	Extracellular (Potential).|FG-GAP 2.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GGTGCCAACTGGGTCCTTTTC	0.418000												
CUBN	8029	broad.mit.edu	37	10	16867001	16867001	+	Silent	SNP	G	G	A	rs146137990		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:16867001G>A	uc001ioo.2	-	67	10897	c.10845C>T	c.(10843-10845)TCC>TCT	p.S3615S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3615	CUB 27.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATCGGAATGCGGATGGACGCC	0.468000												
CUBN	8029	broad.mit.edu	37	10	16911739	16911739	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:16911739C>T	uc001ioo.2	-	59	9402	c.9350G>A	c.(9349-9351)CGC>CAC	p.R3117H	CUBN_uc009xjq.1_RNA|CUBN_uc009xjr.1_Missense_Mutation_p.R473H	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3117	CUB 23.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATTTGGTGGGCGCTTGGAACC	0.498000												
ARMC3	219681	broad.mit.edu	37	10	23244766	23244766	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:23244766T>G	uc001irm.3	+	4	280	c.197T>G	c.(196-198)CTT>CGT	p.L66R	ARMC3_uc010qcv.1_Missense_Mutation_p.L66R|ARMC3_uc010qcw.1_5'UTR|ARMC3_uc001irn.1_5'UTR	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	66	ARM 2.						binding				0						CTCCTTGAACTTGGAGCTGTG	0.388000												
ITGB1	3688	broad.mit.edu	37	10	33209310	33209310	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:33209310G>T	uc001iws.3	-	10	1268	c.1132C>A	c.(1132-1134)CTT>ATT	p.L378I	ITGB1_uc001iwp.3_Missense_Mutation_p.L378I|ITGB1_uc001iwq.3_Missense_Mutation_p.L378I|ITGB1_uc001iwr.3_Missense_Mutation_p.L378I|ITGB1_uc001iwt.3_Missense_Mutation_p.L378I|ITGB1_uc001iwu.1_Missense_Mutation_p.L378I	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	378	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TCTGAGGAAAGGGACTAAAAG	0.353000												
NRP1	8829	broad.mit.edu	37	10	33475246	33475246	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:33475246G>A	uc001iwx.3	-	14	2756	c.2233C>T	c.(2233-2235)CCA>TCA	p.P745S	NRP1_uc001iwv.3_Missense_Mutation_p.P745S|NRP1_uc009xlz.2_Missense_Mutation_p.P739S|NRP1_uc001iww.3_Missense_Mutation_p.P557S|NRP1_uc001iwy.3_Missense_Mutation_p.P738S	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	745	Extracellular (Potential).|MAM.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	TACTCCTCTGGCTTCTGGTAG	0.532000												
BMS1	9790	broad.mit.edu	37	10	43292065	43292065	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:43292065A>C	uc001jaj.2	+	10	1731	c.1373A>C	c.(1372-1374)AAC>ACC	p.N458T		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	458					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GGGTTGGAAAACGGCTCTAGT	0.443000												
ZNF32	7580	broad.mit.edu	37	10	44139887	44139887	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:44139887G>A	uc001jbb.2	-	3	622	c.433C>T	c.(433-435)CGA>TGA	p.R145*	uc001jba.2_Intron|ZNF32_uc001jbc.2_Nonsense_Mutation_p.R145*	NM_001005368	NP_001005368	P17041	ZNF32_HUMAN	zinc finger protein 32	145	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)		AGACTACCTCGTTGACTGAAG	0.483000												
GDF2	2658	broad.mit.edu	37	10	48416403	48416403	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:48416403C>T	uc001jfa.1	-	1	454	c.291G>A	c.(289-291)ACG>ACA	p.T97T		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	97					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						ACTTATCGGACGTGTACCTGT	0.582000												
ANK3	288	broad.mit.edu	37	10	61833987	61833987	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:61833987C>A	uc001jky.2	-	37	6844	c.6652G>T	c.(6652-6654)GCA>TCA	p.A2218S	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2218					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ATTTGAAATGCTTTAACCTTT	0.433000												
LRIT2	340745	broad.mit.edu	37	10	85981787	85981787	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:85981787C>T	uc001kcy.2	-	3	1550	c.1542G>A	c.(1540-1542)CCG>CCA	p.P514P	LRIT2_uc010qmc.1_Silent_p.P524P	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	514						integral to membrane				ovary(2)	2						CCTTGGACTGCGGGGCTGCAG	0.617000												
WAPAL	23063	broad.mit.edu	37	10	88230820	88230820	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:88230820G>A	uc001kdo.2	-	8	2513	c.2071C>T	c.(2071-2073)CGA>TGA	p.R691*	WAPAL_uc009xsv.2_Nonsense_Mutation_p.R5*|WAPAL_uc001kdn.2_Nonsense_Mutation_p.R728*|WAPAL_uc009xsw.2_Nonsense_Mutation_p.R685*	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	691	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						AGGTGCATTCGAAAACTGGGC	0.418000												
CYP2C19	1557	broad.mit.edu	37	10	96484237	96484237	+	Translation_Start_Site	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:96484237C>A	uc010qny.1	+	5	765	c.-93C>A	c.(-95--91)ACCTG>ACATG		CYP2C18_uc001kjv.3_Missense_Mutation_p.L366M|CYP2C18_uc001kjw.3_Missense_Mutation_p.L307M|CYP2C19_uc009xus.1_Intron	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,						exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CCCCACCAACCTGCCCCATGC	0.512000												
C10orf12	26148	broad.mit.edu	37	10	98742860	98742860	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:98742860G>T	uc001kmv.2	+	1	1820	c.1713G>T	c.(1711-1713)GAG>GAT	p.E571D		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	571										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AAACTCTGGAGGACACAGAAA	0.502000												
ENTPD7	57089	broad.mit.edu	37	10	101458568	101458568	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:101458568C>T	uc001kqa.3	+	10	1466	c.1288C>T	c.(1288-1290)CGC>TGC	p.R430C	ENTPD7_uc009xwl.2_Missense_Mutation_p.R432C	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	430	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		GGATGTGTTGCGCATTGGTGG	0.413000												
SUFU	51684	broad.mit.edu	37	10	104264032	104264032	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:104264032C>T	uc001kvy.1	+	1	269	c.123C>T	c.(121-123)TGC>TGT	p.C41C	SUFU_uc001kvw.1_Silent_p.C41C|SUFU_uc001kvx.2_Silent_p.C41C|ACTR1A_uc001kvv.2_5'Flank|ACTR1A_uc010qqn.1_5'Flank|ACTR1A_uc010qqo.1_5'Flank	NM_016169	NP_057253	Q9UMX1	SUFU_HUMAN	suppressor of fused	41					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			central_nervous_system(4)|skin(2)|breast(1)	7		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		ACGGAGAGTGCCGCCGCCTTT	0.483000			D|F|S		medulloblastoma	medulloblastoma			Medulloblastoma_associated_with_Germline_SUFU_Mutation			
WDR11	55717	broad.mit.edu	37	10	122625206	122625206	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:122625206G>A	uc010qtf.1	+	7	1182	c.944G>A	c.(943-945)CGT>CAT	p.R315H	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_Translation_Start_Site	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	315						integral to membrane					0						ATAACTTTACGTGTTCGAAGA	0.274000												
HMX2	3167	broad.mit.edu	37	10	124908090	124908090	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:124908090T>G	uc001lhc.1	+	1	453	c.196T>G	c.(196-198)TTC>GTC	p.F66V		NM_005519	NP_005510	A2RU54	HMX2_HUMAN	H6 family homeobox 2	66					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.169)|Colorectal(57;0.207)|Glioma(114;0.222)		Colorectal(40;0.123)|COAD - Colon adenocarcinoma(40;0.141)		GCCCGCCTGCTTCTGCCCAGA	0.697000												
BUB3	9184	broad.mit.edu	37	10	124921806	124921806	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:124921806A>C	uc001lhe.2	+	6	873	c.631A>C	c.(631-633)AGC>CGC	p.S211R	BUB3_uc009yah.2_Missense_Mutation_p.S163R|BUB3_uc001lhf.3_Missense_Mutation_p.S211R|BUB3_uc001lhd.2_Missense_Mutation_p.S211R|BUB3_uc010qud.1_Missense_Mutation_p.S131R	NM_004725	NP_004716	O43684	BUB3_HUMAN	budding uninhibited by benzimidazoles 3 isoform	211					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|attachment of spindle microtubules to kinetochore|cell division|meiosis|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	condensed chromosome kinetochore|cytosol|nucleus	protein binding			ovary(1)	1		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)				TTTGGACCCAAGCCCTGAGGT	0.403000												
B4GALNT4	338707	broad.mit.edu	37	11	373264	373264	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:373264T>C	uc001lpb.2	+	6	618	c.609T>C	c.(607-609)GCT>GCC	p.A203A		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	203	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCCTGCTGCTGCCCAGCTTG	0.632000												
MUC5B	727897	broad.mit.edu	37	11	1267503	1267503	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:1267503G>A	uc009ycr.1	+	49	11268	c.11142G>A	c.(11140-11142)ACG>ACA	p.T3714T	MUC5B_uc001ltb.2_Silent_p.T3134T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3131	7 X Cys-rich subdomain repeats.|Thr-rich.|17 X approximate tandem repeats, Ser/Thr- rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCGGGGACGACCTGGATCC	0.657000												
TRPM5	29850	broad.mit.edu	37	11	2428999	2428999	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:2428999C>T	uc001lwm.3	-	19	2935	c.2926G>A	c.(2926-2928)GCC>ACC	p.A976T	TRPM5_uc010qxl.1_Missense_Mutation_p.A976T|TRPM5_uc009ydn.2_Missense_Mutation_p.A978T	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	976	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CTGAACATGGCGATGAGCAGG	0.602000												
OR52I2	143502	broad.mit.edu	37	11	4608096	4608096	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:4608096T>C	uc010qyh.1	+	1	54	c.54T>C	c.(52-54)ATT>ATC	p.I18I		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTTGTGCATTAACAGGAAAA	0.448000												
OR51F2	119694	broad.mit.edu	37	11	4843262	4843262	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:4843262C>T	uc010qyn.1	+	1	647	c.647C>T	c.(646-648)GCG>GTG	p.A216V		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGTCTGTTTGCGCTTTTGTCC	0.478000												
UBQLN3	50613	broad.mit.edu	37	11	5529610	5529610	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:5529610G>A	uc001may.1	-	2	1265	c.1179C>T	c.(1177-1179)GGC>GGT	p.G393G	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_5'Flank|OR51B5_uc001maq.1_5'Flank	NM_017481	NP_059509	Q9H347	UBQL3_HUMAN	ubiquilin 3	393										ovary(3)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGAGAGGCTGGCCTGACCCAG	0.577000												
OR56A4	120793	broad.mit.edu	37	11	6023985	6023985	+	Missense_Mutation	SNP	C	C	T	rs146498967		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:6023985C>T	uc010qzv.1	-	1	394	c.394G>A	c.(394-396)GTC>ATC	p.V132I		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGGGGATGACGGTGAGGCAG	0.567000												
OR2AG1	144125	broad.mit.edu	37	11	6806831	6806831	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:6806831C>T	uc001mer.1	+	1	563	c.563C>T	c.(562-564)GCC>GTC	p.A188V		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTGAAGGTGGCCTGTGCTGAT	0.488000												
ZNF214	7761	broad.mit.edu	37	11	7021534	7021534	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:7021534A>G	uc001mfa.2	-	3	1683	c.1380T>C	c.(1378-1380)CAT>CAC	p.H460H	ZNF214_uc010ray.1_Silent_p.H460H|ZNF214_uc009yfh.1_Silent_p.H460H	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	460	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		GGACTCTCTGATGAATGCGAA	0.418000												
ARNTL	406	broad.mit.edu	37	11	13393740	13393740	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:13393740G>T	uc001mkr.2	+	13	1259	c.851G>T	c.(850-852)AGC>ATC	p.S284I	ARNTL_uc001mko.2_Missense_Mutation_p.S240I|ARNTL_uc001mkp.2_Missense_Mutation_p.S283I|ARNTL_uc001mkq.2_Missense_Mutation_p.S283I|ARNTL_uc001mks.2_Missense_Mutation_p.S241I|ARNTL_uc001mkt.2_Missense_Mutation_p.S284I|ARNTL_uc001mku.2_RNA|ARNTL_uc009ygm.1_Intron|ARNTL_uc001mkv.1_Missense_Mutation_p.S241I|ARNTL_uc001mkw.2_Missense_Mutation_p.S241I|ARNTL_uc001mkx.2_Missense_Mutation_p.S282I	NM_001178	NP_001169	O00327	BMAL1_HUMAN	aryl hydrocarbon receptor nuclear	284					circadian rhythm|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	aryl hydrocarbon receptor binding|DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0				Epithelial(150;0.0243)		ACAATCCACAGCACAGGCTAT	0.512000												
PIK3C2A	5286	broad.mit.edu	37	11	17190440	17190440	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:17190440A>G	uc001mmq.3	-	1	915	c.849T>C	c.(847-849)AAT>AAC	p.N283N	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Intron|PIK3C2A_uc001mmr.3_RNA|PIK3C2A_uc010rcx.1_Silent_p.N283N|PIK3C2A_uc009ygv.1_Silent_p.N283N	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	283					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	ATACCTCCACATTATCCACCT	0.393000												
E2F8	79733	broad.mit.edu	37	11	19251862	19251862	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:19251862C>A	uc001mpm.2	-	9	1806	c.1284G>T	c.(1282-1284)CAG>CAT	p.Q428H	E2F8_uc009yhv.2_Intron|E2F8_uc001mpn.3_Missense_Mutation_p.Q428H	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	428					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						GTGCAGAATTCTGAGAACTCT	0.418000												
NELL1	4745	broad.mit.edu	37	11	20907060	20907060	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:20907060C>T	uc001mqe.2	+	5	730	c.577C>T	c.(577-579)CGC>TGC	p.R193C	NELL1_uc001mqf.2_Missense_Mutation_p.R193C|NELL1_uc009yid.2_Missense_Mutation_p.R221C|NELL1_uc010rdo.1_Missense_Mutation_p.R136C|NELL1_uc010rdp.1_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	193	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GCTTGGCCAGCGCAACCAAAA	0.398000												
SLC17A6	57084	broad.mit.edu	37	11	22387116	22387116	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:22387116A>G	uc001mqk.2	+	7	1185	c.772A>G	c.(772-774)ATG>GTG	p.M258V		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	258	Helical; (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						GGTCTGGTACATGTTTTGGCT	0.403000												
NAT10	55226	broad.mit.edu	37	11	34133754	34133754	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:34133754G>C	uc001mvk.2	+	4	600	c.356G>C	c.(355-357)GGC>GCC	p.G119A	NAT10_uc010ren.1_Missense_Mutation_p.G47A	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	119						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				AATACCTTCGGCATGTGTGTG	0.512000												
TRAF6	7189	broad.mit.edu	37	11	36520142	36520142	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:36520142A>T	uc001mwr.1	-	4	685	c.345T>A	c.(343-345)AAT>AAA	p.N115K	TRAF6_uc001mws.1_Missense_Mutation_p.N115K	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	115	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				GAAATAGTTGATTTTCCAGCA	0.353000												
MED19	219541	broad.mit.edu	37	11	57472562	57472562	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:57472562A>G	uc001nla.1	-	2	379	c.357T>C	c.(355-357)CCT>CCC	p.P119P	MED19_uc001nlb.2_Silent_p.P119P	NM_153450	NP_703151	A0JLT2	MED19_HUMAN	mediator complex subunit 19	119					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex		p.P119L(1)		ovary(2)	2						CATGGGAACCAGGCAGATCAA	0.493000												
TMEM132A	54972	broad.mit.edu	37	11	60697990	60697990	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:60697990T>C	uc001nqj.2	+	5	1068	c.875T>C	c.(874-876)GTG>GCG	p.V292A	TMEM132A_uc001nqi.2_Missense_Mutation_p.V292A|TMEM132A_uc001nqk.2_Missense_Mutation_p.V305A|TMEM132A_uc001nql.1_Missense_Mutation_p.V305A	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	292	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						AGGATCAAGGTGAAGAAGGGG	0.592000												
DDB1	1642	broad.mit.edu	37	11	61071397	61071397	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:61071397G>A	uc001nrc.3	-	22	2998	c.2772C>T	c.(2770-2772)GGC>GGT	p.G924G	DDB1_uc010rle.1_Silent_p.G235G|DDB1_uc010rlf.1_Silent_p.G924G	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	924	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						GCATAAGGTCGCCCACCAGGA	0.542000								NER				
DAK	26007	broad.mit.edu	37	11	61106764	61106764	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:61106764C>T	uc001nre.2	+	5	600	c.343C>T	c.(343-345)CGG>TGG	p.R115W	DDB1_uc010rlf.1_Intron|DAK_uc009ynm.1_Missense_Mutation_p.R45W	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	115	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						CACTGGGGATCGGCTCAACTT	0.642000												
FLRT1	23769	broad.mit.edu	37	11	63884259	63884259	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:63884259G>A	uc001nyi.1	+	2	861	c.520G>A	c.(520-522)GCC>ACC	p.A174T	MACROD1_uc001nyh.2_Intron	NM_013280	NP_037412	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein	146	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity				0						GGACGCCTTCGCCGACAGCAA	0.642000												
NRXN2	9379	broad.mit.edu	37	11	64428414	64428414	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:64428414G>A	uc001oar.2	-	11	2435	c.1996C>T	c.(1996-1998)CGT>TGT	p.R666C	NRXN2_uc001oas.2_Missense_Mutation_p.R635C|NRXN2_uc001oaq.2_Missense_Mutation_p.R333C	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TCTCGGCTACGCCCATCTATG	0.692000												
TIGD3	220359	broad.mit.edu	37	11	65124144	65124144	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:65124144G>A	uc001odo.3	+	2	1028	c.865G>A	c.(865-867)GCC>ACC	p.A289T		NM_145719	NP_663771	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	289	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						GCCTCTGGCCGCCTCTAGCAC	0.652000												
EFEMP2	30008	broad.mit.edu	37	11	65637592	65637592	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:65637592C>T	uc001ofy.3	-	6	801	c.607G>A	c.(607-609)GAT>AAT	p.D203N	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.D203N	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	203	EGF-like 4; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		CCAGCCTCACCAACACAGGAG	0.682000												
CTSF	8722	broad.mit.edu	37	11	66332220	66332220	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:66332220C>T	uc001oip.2	-	10	1313	c.1223G>A	c.(1222-1224)GGC>GAC	p.G408D		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	408					proteolysis	lysosome	cysteine-type endopeptidase activity				0						CACCTGCATGCCAAAGGCATT	0.632000												
RCE1	9986	broad.mit.edu	37	11	66613485	66613485	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:66613485G>A	uc001ojk.1	+	8	953	c.909G>A	c.(907-909)ACG>ACA	p.T303T	RCE1_uc001ojl.1_Silent_p.T199T	NM_005133	NP_005124	Q9Y256	FACE2_HUMAN	prenyl protein peptidase RCE1 isoform 1	303	Helical; (Potential).				proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			ovary(1)|breast(1)	2						AGCCCCTCACGGACCCCAAGC	0.647000												
RHOD	29984	broad.mit.edu	37	11	66834258	66834258	+	Silent	SNP	C	C	T	rs144971798	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:66834258C>T	uc001ojv.2	+	3	355	c.270C>T	c.(268-270)AGC>AGT	p.S90S		NM_014578	NP_055393	O00212	RHOD_HUMAN	ras homolog D precursor	90					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0						CTGACGCCAGCGTCCTGCTGC	0.612000												
RHOD	29984	broad.mit.edu	37	11	66838974	66838974	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:66838974C>T	uc001ojv.2	+	5	619	c.534C>T	c.(532-534)AAC>AAT	p.N178N		NM_014578	NP_055393	O00212	RHOD_HUMAN	ras homolog D precursor	178					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0						TCCATGACAACGTCCACGCCG	0.677000												
CARNS1	57571	broad.mit.edu	37	11	67187277	67187277	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:67187277C>T	uc009yrp.2	+	6	1164	c.712C>T	c.(712-714)CGG>TGG	p.R238W	PPP1CA_uc001okx.1_Intron|CARNS1_uc010rpr.1_Missense_Mutation_p.R361W|CARNS1_uc001olc.3_Missense_Mutation_p.R377W	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	238					carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0						TGTGGTGTGTCGGACACAGGG	0.652000												
PPFIA1	8500	broad.mit.edu	37	11	70189942	70189942	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:70189942G>A	uc001opo.2	+	15	2073	c.1875G>A	c.(1873-1875)GCG>GCA	p.A625A	PPFIA1_uc001opn.1_Silent_p.A625A|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	625	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AGGCCGACGCGCACACACTAG	0.562000												
FOLH1B	219595	broad.mit.edu	37	11	89424639	89424639	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:89424639A>C	uc001pda.2	+	12	1515	c.989A>C	c.(988-990)AAT>ACT	p.N330T		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	330					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GCAGTAAAAAATTTTACAGAA	0.274000												
KIAA1826	84437	broad.mit.edu	37	11	105880396	105880396	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:105880396G>A	uc001piy.2	-	3	1077	c.904C>T	c.(904-906)CGA>TGA	p.R302*	KIAA1826_uc001piz.2_Nonsense_Mutation_p.R302*	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	302	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		AAGCGTTCTCGCTCAAGTTTT	0.413000												
ATM	472	broad.mit.edu	37	11	108164110	108164110	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:108164110T>C	uc001pkb.1	+	31	5067	c.4682T>C	c.(4681-4683)CTT>CCT	p.L1561P	ATM_uc009yxr.1_Missense_Mutation_p.L1561P|ATM_uc001pke.1_Missense_Mutation_p.L213P|ATM_uc001pkf.2_Intron	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1561					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ACGATTAAGCTTTTAGATCCT	0.289000			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)		
PHLDB1	23187	broad.mit.edu	37	11	118516454	118516454	+	Missense_Mutation	SNP	G	G	A	rs137998974		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:118516454G>A	uc001ptr.1	+	18	3771	c.3418G>A	c.(3418-3420)GCG>ACG	p.A1140T	PHLDB1_uc001pts.2_Missense_Mutation_p.A1140T|PHLDB1_uc001ptt.2_Missense_Mutation_p.A1093T|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_Missense_Mutation_p.A955T|PHLDB1_uc001ptw.1_Missense_Mutation_p.A495T|PHLDB1_uc009zai.1_Missense_Mutation_p.A176T|PHLDB1_uc001ptx.1_Missense_Mutation_p.A176T|PHLDB1_uc010ryi.1_3'UTR	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	1140											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TCTCCCCAGCGCGAGTGGTCT	0.597000												
POU2F3	25833	broad.mit.edu	37	11	120176450	120176450	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:120176450T>C	uc001pxc.2	+	8	827	c.725T>C	c.(724-726)ATG>ACG	p.M242T	POU2F3_uc010rzk.1_Missense_Mutation_p.M196T|POU2F3_uc010rzl.1_Missense_Mutation_p.M172T|POU2F3_uc001pxe.1_Missense_Mutation_p.M27T	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	242	POU-specific.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		TTCAAGAACATGTGCAAGCTC	0.582000												
GRIK4	2900	broad.mit.edu	37	11	120833350	120833350	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:120833350C>T	uc001pxn.2	+	18	2513	c.2226C>T	c.(2224-2226)GGC>GGT	p.G742G	GRIK4_uc009zav.1_Silent_p.G742G|GRIK4_uc009zaw.1_Silent_p.G742G|GRIK4_uc009zax.1_Silent_p.G742G	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	742	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	AGATTGGGGGCCTGCTGGACA	0.557000												
TECTA	7007	broad.mit.edu	37	11	120976660	120976660	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:120976660A>G	uc010rzo.1	+	2	185	c.185A>G	c.(184-186)TAC>TGC	p.Y62C		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	62					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GGCGTTCCTTACCGCACTGTC	0.428000												
SORL1	6653	broad.mit.edu	37	11	121448108	121448108	+	Silent	SNP	C	C	T	rs138407235		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:121448108C>T	uc001pxx.2	+	25	3659	c.3579C>T	c.(3577-3579)ACC>ACT	p.T1193T	SORL1_uc010rzp.1_Silent_p.T39T	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1193	Extracellular (Potential).|LDL-receptor class A 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CCAACTGTACCGGTCAGTACT	0.502000												
OR10G8	219869	broad.mit.edu	37	11	123900532	123900532	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:123900532A>G	uc001pzp.1	+	1	203	c.203A>G	c.(202-204)GAC>GGC	p.D68G		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	68	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TCGTTCATTGACATGTGGTTC	0.532000												
KIRREL3	84623	broad.mit.edu	37	11	126294613	126294613	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:126294613G>A	uc001qea.2	-	17	2560	c.2199C>T	c.(2197-2199)AGC>AGT	p.S733S	KIRREL3_uc001qeb.2_Silent_p.S721S|ST3GAL4_uc001qdx.1_Intron	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	733	Cytoplasmic (Potential).|Ser-rich.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		GCTTGCCGCTGCTGCTGACGC	0.612000												
ACAD8	27034	broad.mit.edu	37	11	134131749	134131749	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:134131749A>G	uc001qhk.2	+	9	1118	c.1057A>G	c.(1057-1059)ATG>GTG	p.M353V	ACAD8_uc010scp.1_RNA|ACAD8_uc010scq.1_Missense_Mutation_p.M276V|ACAD8_uc001qhl.2_Missense_Mutation_p.M226V	NM_014384	NP_055199	Q9UKU7	ACAD8_HUMAN	acyl-Coenzyme A dehydrogenase family, member 8	353					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding				0	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CTTGTGCTCCATGGCCAAGCT	0.587000												
WNK1	65125	broad.mit.edu	37	12	1005427	1005427	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:1005427C>T	uc001qio.3	+	24	6281	c.5774C>T	c.(5773-5775)GCC>GTC	p.A1925V	WNK1_uc001qip.3_Missense_Mutation_p.A1677V|WNK1_uc001qir.3_Missense_Mutation_p.A1098V	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1925					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CCAGAGAGTGCCCACAAAACT	0.498000												
NTF3	4908	broad.mit.edu	37	12	5603459	5603459	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:5603459C>T	uc001qnl.3	+	1	162	c.79C>T	c.(79-81)CCA>TCA	p.P27S	NTF3_uc001qnk.3_Missense_Mutation_p.P40S	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	27					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						AAGGAGTTTGCCAGAAGACTC	0.413000												
NTF3	4908	broad.mit.edu	37	12	5603725	5603725	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:5603725G>A	uc001qnl.3	+	1	428	c.345G>A	c.(343-345)CCG>CCA	p.P115P	NTF3_uc001qnk.3_Silent_p.P128P	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	115					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						TGGAGCCCCCGCCCTTGTATC	0.612000												
CD4	920	broad.mit.edu	37	12	6925311	6925311	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:6925311A>T	uc001qqv.1	+	6	942	c.697A>T	c.(697-699)ACG>TCG	p.T233S	CD4_uc009zez.1_3'UTR|CD4_uc009zfa.1_RNA|CD4_uc009zfb.1_RNA|CD4_uc010sfj.1_5'UTR|CD4_uc009zfc.1_Missense_Mutation_p.T54S|CD4_uc010sfk.1_5'UTR|CD4_uc010sfl.1_5'UTR|CD4_uc010sfm.1_5'UTR	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	233	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				TGAAAAGCTGACGGGCAGTGG	0.542000												
CD163L1	283316	broad.mit.edu	37	12	7527225	7527225	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:7527225A>G	uc001qsy.2	-	13	3248	c.3222T>C	c.(3220-3222)TGT>TGC	p.C1074C	CD163L1_uc010sge.1_Silent_p.C1084C	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	1074	SRCR 10.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CCAGCTTTTGACACACCACGT	0.607000											OREG0021653	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
CD163L1	283316	broad.mit.edu	37	12	7531592	7531592	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:7531592C>T	uc001qsy.2	-	9	2379	c.2353G>A	c.(2353-2355)GCA>ACA	p.A785T	CD163L1_uc010sge.1_Missense_Mutation_p.A795T	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	785	SRCR 7.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ATCAAACTTGCTTCCATATTT	0.318000												
SLC2A14	144195	broad.mit.edu	37	12	7981304	7981304	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:7981304C>T	uc001qtk.2	-	11	1534	c.741G>A	c.(739-741)ACG>ACA	p.T247T	SLC2A14_uc001qtl.2_Silent_p.T224T|SLC2A14_uc001qtm.2_Silent_p.T224T|SLC2A14_uc010sgg.1_Silent_p.T138T|SLC2A14_uc001qtn.2_Silent_p.T247T|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Silent_p.T262T	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	247	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		ACTCACTCCGCGTAGCATTCT	0.423000												
GOLT1B	51026	broad.mit.edu	37	12	21665273	21665273	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:21665273T>C	uc001rez.2	+	4	500	c.341T>C	c.(340-342)GTC>GCC	p.V114A	GOLT1B_uc009zis.2_RNA|GOLT1B_uc009zit.2_RNA|GOLT1B_uc009ziu.2_RNA	NM_016072	NP_057156	Q9Y3E0	GOT1B_HUMAN	golgi transport 1 homolog B	114	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport|vesicle-mediated transport	endoplasmic reticulum|Golgi membrane|integral to membrane	signal transducer activity				0						AGAGTGCCAGTCCTTGGATCC	0.338000												
ABCC9	10060	broad.mit.edu	37	12	22035726	22035726	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:22035726C>T	uc001rfi.1	-	14	2013	c.1993G>A	c.(1993-1995)GCA>ACA	p.A665T	ABCC9_uc001rfh.2_Missense_Mutation_p.A665T|ABCC9_uc001rfj.1_Intron	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	665	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TCTGTTTCTGCGGGACGTAGA	0.378000												
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)		
ITPR2	3709	broad.mit.edu	37	12	26784907	26784907	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:26784907G>A	uc001rhg.2	-	22	3243	c.2826C>T	c.(2824-2826)AGC>AGT	p.S942S		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	942	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CATCCGGCACGCTCATGGGGA	0.537000												
ITPR2	3709	broad.mit.edu	37	12	26839488	26839488	+	Silent	SNP	C	C	T	rs117349764	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:26839488C>T	uc001rhg.2	-	11	1491	c.1074G>A	c.(1072-1074)CCG>CCA	p.P358P		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	358	Cytoplasmic (Potential).|MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CATTGCCATGCGGGACTGAAA	0.423000												
MED21	9412	broad.mit.edu	37	12	27181274	27181274	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:27181274G>T	uc001rhp.1	+	4	345	c.315G>T	c.(313-315)GAG>GAT	p.E105D	MED21_uc009zjh.1_RNA	NM_004264	NP_004255	Q13503	MED21_HUMAN	mediator complex subunit 21	105					positive regulation of transcription from RNA polymerase II promoter	mediator complex	DNA-directed RNA polymerase activity|transcription coactivator activity				0	Colorectal(261;0.0847)					CATGTCTGGAGGATGTTGTTT	0.403000												
SYT10	341359	broad.mit.edu	37	12	33579288	33579288	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:33579288C>T	uc001rll.1	-	2	591	c.294G>A	c.(292-294)CAG>CAA	p.Q98Q	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	98	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTGAAATGCTCTGTGGAAGCG	0.423000												
LRRK2	120892	broad.mit.edu	37	12	40672043	40672043	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:40672043G>T	uc001rmg.3	+	18	2342	c.2221G>T	c.(2221-2223)GGA>TGA	p.G741*	LRRK2_uc001rmh.1_Nonsense_Mutation_p.G363*	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	741					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGCAAAGGAGGGATCTTCTTT	0.393000												
PDZRN4	29951	broad.mit.edu	37	12	41967251	41967251	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:41967251G>A	uc010skn.1	+	10	2141	c.2073G>A	c.(2071-2073)AAG>AAA	p.K691K	PDZRN4_uc001rmq.3_Silent_p.K632K|PDZRN4_uc009zjz.2_Silent_p.K630K|PDZRN4_uc001rmr.2_Silent_p.K517K	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	890							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TGGAATGGAAGGTGAAAATTA	0.502000												
GXYLT1	283464	broad.mit.edu	37	12	42491296	42491296	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:42491296T>C	uc001rms.3	-	7	1334	c.1109A>G	c.(1108-1110)TAC>TGC	p.Y370C	GXYLT1_uc001rmt.3_Missense_Mutation_p.Y339C	NM_173601	NP_775872	Q4G148	GXLT1_HUMAN	glycosyltransferase 8 domain containing 3	370	Lumenal (Potential).				O-glycan processing	integral to membrane	UDP-xylosyltransferase activity				0						ATCGTCATGGTAAACACCTCT	0.333000												
ARID2	196528	broad.mit.edu	37	12	46246350	46246350	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:46246350C>T	uc001ros.1	+	15	4444	c.4444C>T	c.(4444-4446)CAA>TAA	p.Q1482*	ARID2_uc001ror.2_Nonsense_Mutation_p.Q1482*|ARID2_uc009zkg.1_Nonsense_Mutation_p.Q938*|ARID2_uc009zkh.1_Nonsense_Mutation_p.Q1109*|ARID2_uc001rou.1_Nonsense_Mutation_p.Q816*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1482					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACAGGGACATCAAATCATAGC	0.448000												
CCNT1	904	broad.mit.edu	37	12	49087792	49087792	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:49087792G>A	uc001rse.1	-	9	1528	c.1205C>T	c.(1204-1206)GCC>GTC	p.A402V	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.A117V	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	402	Potential.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						CCTCTTCTGGGCAGCCAATTC	0.443000												
PRPF40B	25766	broad.mit.edu	37	12	50029022	50029022	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:50029022G>A	uc001rur.1	+	12	1140	c.1076G>A	c.(1075-1077)CGC>CAC	p.R359H	PRPF40B_uc001rup.1_Missense_Mutation_p.R381H|PRPF40B_uc001ruq.1_Missense_Mutation_p.R353H|PRPF40B_uc001rus.1_Missense_Mutation_p.R302H	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	359					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						CAGCATGAACGCATGACCTCC	0.622000												
KRT1	3848	broad.mit.edu	37	12	53069130	53069130	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:53069130G>A	uc001sau.1	-	9	1841	c.1782C>T	c.(1780-1782)GGC>GGT	p.G594G	KRT1_uc001sav.1_Silent_p.G587G	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	594	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						tgccgccgccgccgcctccag	0.274000												
AVPR1A	552	broad.mit.edu	37	12	63544484	63544484	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:63544484C>T	uc001sro.1	-	1	2107	c.133G>A	c.(133-135)GTG>ATG	p.V45M		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	45	Extracellular (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	TCGTTGCGCACGTCCCTCGGT	0.697000												
LEMD3	23592	broad.mit.edu	37	12	65609822	65609822	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:65609822A>G	uc001ssl.1	+	3	1632	c.1626A>G	c.(1624-1626)GCA>GCG	p.A542A	LEMD3_uc009zqo.1_Silent_p.A541A	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	542					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		CACAGCTTGCAGGTAATTGTT	0.274000												
ELK3	2004	broad.mit.edu	37	12	96641453	96641453	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:96641453G>A	uc001teo.1	+	3	1222	c.943G>A	c.(943-945)GCC>ACC	p.A315T		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	315					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					CGGCTCCATCGCCCTCAACAG	0.597000												
FICD	11153	broad.mit.edu	37	12	108912784	108912784	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:108912784C>T	uc001tmx.1	+	3	1055	c.909C>T	c.(907-909)CCC>CCT	p.P303P		NM_007076	NP_009007	Q9BVA6	FICD_HUMAN	Huntingtin interacting protein E	303	Fido.				negative regulation of Rho GTPase activity	integral to membrane	binding|protein adenylyltransferase activity				0						ACGTGGACCCCGTGGAAGCCG	0.592000												
TPCN1	53373	broad.mit.edu	37	12	113733856	113733856	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:113733856G>A	uc001tuw.2	+	28	2723	c.2426G>A	c.(2425-2427)CGC>CAC	p.R809H	TPCN1_uc001tux.2_Missense_Mutation_p.R881H|TPCN1_uc010syu.1_RNA	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	809	Cytoplasmic (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						CCAGGCAGCCGCCAGCGCTCC	0.602000												
RPLP0	6175	broad.mit.edu	37	12	120636391	120636391	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:120636391A>G	uc001txp.2	-	6	854	c.617T>C	c.(616-618)ATC>ACC	p.I206T	RPLP0_uc001txq.2_Missense_Mutation_p.I206T|RPLP0_uc001txr.2_Intron|uc001txs.1_5'Flank	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	206					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCCTCTGTGATATCAAGCAC	0.512000												
GPR133	283383	broad.mit.edu	37	12	131476867	131476867	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:131476867A>G	uc001uit.3	+	8	1455	c.896A>G	c.(895-897)TAC>TGC	p.Y299C	GPR133_uc010tbm.1_Missense_Mutation_p.Y331C	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	299	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ATACTGAGTTACCTCCAAAAT	0.478000												
POLE	5426	broad.mit.edu	37	12	133254218	133254218	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:133254218G>A	uc001uks.1	-	7	710	c.666C>T	c.(664-666)CGC>CGT	p.R222R	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.R195R	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	222					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CATCGTACTCGCGCATGTCCA	0.502000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage				
ATP8A2	51761	broad.mit.edu	37	13	26411318	26411318	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr13:26411318G>A	uc001uqk.2	+	29	2914	c.2772G>A	c.(2770-2772)CCG>CCA	p.P924P	ATP8A2_uc010tdi.1_Silent_p.P859P|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Silent_p.P474P	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	884	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CCGCTTTGCCGCCCTTCACTC	0.498000												
KL	9365	broad.mit.edu	37	13	33591184	33591184	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr13:33591184C>T	uc001uus.2	+	1	614	c.606C>T	c.(604-606)GAC>GAT	p.D202D	KL_uc001uur.1_Intron	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	202	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GCCTGCAGGACGCCTACGGCG	0.697000												
ENOX1	55068	broad.mit.edu	37	13	43918697	43918697	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr13:43918697G>A	uc001uza.3	-	9	1313	c.1013C>T	c.(1012-1014)GCC>GTC	p.A338V	ENOX1_uc001uzb.3_Missense_Mutation_p.A338V|ENOX1_uc001uzc.3_Missense_Mutation_p.A338V|ENOX1_uc001uyz.3_5'UTR|ENOX1_uc010tfm.1_Missense_Mutation_p.A151V	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	338	Potential.				electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		CCCAGTTAAGGCATTTTTAAA	0.403000												
RNF219	79596	broad.mit.edu	37	13	79191059	79191059	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr13:79191059G>A	uc001vkw.1	-	6	896	c.837C>T	c.(835-837)GGC>GGT	p.G279G	uc001vku.1_RNA|RNF219_uc010afb.1_Silent_p.G89G|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	279							zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		TGCTCCCTTTGCCATCTGCAG	0.453000												
DOCK9	23348	broad.mit.edu	37	13	99449686	99449686	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr13:99449686G>A	uc001vnt.2	-	53	6074	c.6019C>T	c.(6019-6021)CGA>TGA	p.R2007*	DOCK9_uc001vnw.2_Nonsense_Mutation_p.R2006*|DOCK9_uc001vnq.2_Nonsense_Mutation_p.R554*|DOCK9_uc001vnr.2_Nonsense_Mutation_p.R636*|DOCK9_uc010tin.1_Nonsense_Mutation_p.R625*|DOCK9_uc001vns.2_Nonsense_Mutation_p.R542*|DOCK9_uc010tio.1_Nonsense_Mutation_p.R662*|DOCK9_uc010tip.1_Nonsense_Mutation_p.R703*	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	2007	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TCAGGATATCGCTTTGTGTTT	0.388000												
KDELC1	79070	broad.mit.edu	37	13	103443452	103443452	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr13:103443452C>T	uc001vpq.3	-	6	1266	c.882G>A	c.(880-882)ACG>ACA	p.T294T	KDELC1_uc001vpr.3_Silent_p.T75T	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	294						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AGGGAGGACCCGTGTTAGCTT	0.478000												
F7	2155	broad.mit.edu	37	13	113771902	113771902	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr13:113771902C>T	uc001vsv.2	+	8	848	c.797C>T	c.(796-798)GCG>GTG	p.A266V	F7_uc001vsw.2_Missense_Mutation_p.A244V|F7_uc010tjt.1_Missense_Mutation_p.A197V	NM_000131	NP_000122	P08709	FA7_HUMAN	coagulation factor VII isoform a precursor	266	Peptidase S1.		A -> T (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	AACCTGATCGCGGTGCTGGGT	0.632000												
LRRC16B	90668	broad.mit.edu	37	14	24532580	24532580	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:24532580C>T	uc001wlj.2	+	31	2974	c.2817C>T	c.(2815-2817)ATC>ATT	p.I939I	LRRC16B_uc001wlk.2_Silent_p.I35I	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	939										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		ATCTGGGGATCCCCCCTGGCT	0.582000												
RALGAPA1	253959	broad.mit.edu	37	14	36159176	36159176	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:36159176G>A	uc001wti.2	-	17	2691	c.2300C>T	c.(2299-2301)ACT>ATT	p.T767I	RALGAPA1_uc001wtj.2_Missense_Mutation_p.T767I|RALGAPA1_uc010tpv.1_Missense_Mutation_p.T767I|RALGAPA1_uc010tpw.1_Missense_Mutation_p.T814I|RALGAPA1_uc001wtk.1_Missense_Mutation_p.T665I	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	767					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TCTGACTCTAGTTGAGCGGGG	0.333000												
RALGAPA1	253959	broad.mit.edu	37	14	36194349	36194349	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:36194349G>A	uc001wti.2	-	14	2138	c.1747C>T	c.(1747-1749)CTG>TTG	p.L583L	RALGAPA1_uc001wtj.2_Silent_p.L583L|RALGAPA1_uc010tpv.1_Silent_p.L583L|RALGAPA1_uc010tpw.1_Silent_p.L583L|RALGAPA1_uc001wtk.1_Silent_p.L434L	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	583					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AACACAAGCAGCATCTGTTCC	0.353000												
SSTR1	6751	broad.mit.edu	37	14	38679601	38679601	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:38679601G>A	uc001wul.1	+	3	1624	c.1007G>A	c.(1006-1008)CGC>CAC	p.R336H	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	336	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	TCTTTCCAACGCATCCTATGC	0.572000												
SYNE2	23224	broad.mit.edu	37	14	64630227	64630227	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:64630227G>A	uc001xgm.2	+	89	16637	c.16407G>A	c.(16405-16407)CCG>CCA	p.P5469P	SYNE2_uc001xgl.2_Silent_p.P5469P|SYNE2_uc010apy.2_Silent_p.P1854P|SYNE2_uc001xgn.2_Silent_p.P431P|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5469	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGCTCCTCCCGGGCCCCCTGC	0.478000												
SIPA1L1	26037	broad.mit.edu	37	14	72054698	72054698	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:72054698C>T	uc001xms.2	+	2	457	c.109C>T	c.(109-111)CGG>TGG	p.R37W	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R37W|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R37W|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R37W	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	37					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TTTCTACATGCGGCGCTTCCG	0.547000												
RGS6	9628	broad.mit.edu	37	14	73029132	73029132	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:73029132C>T	uc001xna.3	+	17	1899	c.1376C>T	c.(1375-1377)TCG>TTG	p.S459L	RGS6_uc010ttn.1_Missense_Mutation_p.S477L|RGS6_uc001xmx.3_Missense_Mutation_p.S459L|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.S477L|RGS6_uc001xmz.1_Intron	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	459					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAGGGAAAGTCGCTGGCGGGC	0.647000												
PAPLN	89932	broad.mit.edu	37	14	73718470	73718470	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:73718470C>T	uc010ttx.1	+	8	932	c.769C>T	c.(769-771)CGG>TGG	p.R257W	PAPLN_uc001xnw.3_Missense_Mutation_p.R230W|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.R257W	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	257						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCATTACGAGCGGGGTGCTGA	0.657000												
C14orf43	91748	broad.mit.edu	37	14	74205491	74205491	+	Silent	SNP	C	C	T	rs142510283		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:74205491C>T	uc001xot.2	-	2	2004	c.1221G>A	c.(1219-1221)TCG>TCA	p.S407S	C14orf43_uc001xou.2_Silent_p.S407S|C14orf43_uc010tud.1_Silent_p.S407S|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	407					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		GCAGTAGCTGCGACTCCCTCA	0.662000												
TMED8	283578	broad.mit.edu	37	14	77808279	77808279	+	Silent	SNP	A	A	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:77808279A>T	uc001xto.1	-	6	813	c.813T>A	c.(811-813)GGT>GGA	p.G271G	TMED8_uc010ast.1_RNA|TMED8_uc001xtn.1_Silent_p.G115G	NM_213601	NP_998766	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain	271	GOLD.				transport	integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		CCCCATAGCGACCCCGCAAGG	0.602000												
FAM181A	90050	broad.mit.edu	37	14	94395003	94395003	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:94395003G>A	uc001ybz.1	+	3	865	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Silent_p.Q124Q|FAM181A_uc001yca.1_Silent_p.Q124Q	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	186											0						AAGCTGCCCAGCCTGGCCAGG	0.632000												
AHNAK2	113146	broad.mit.edu	37	14	105411774	105411774	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr14:105411774C>T	uc010axc.1	-	7	10134	c.10014G>A	c.(10012-10014)GCG>GCA	p.A3338A	AHNAK2_uc001ypx.2_Silent_p.A3238A	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3338						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CGTCGGCCTCCGCCTTCGGCG	0.617000												
RYR3	6263	broad.mit.edu	37	15	33873841	33873841	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:33873841C>T	uc001zhi.2	+	14	1640	c.1570C>T	c.(1570-1572)CTG>TTG	p.L524L	RYR3_uc010bar.2_Silent_p.L524L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	524	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTACAAATTGCTGGGTAAGTA	0.458000												
TP53BP1	7158	broad.mit.edu	37	15	43714236	43714236	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:43714236T>G	uc001zrs.2	-	19	4050	c.3902A>C	c.(3901-3903)GAT>GCT	p.D1301A	TP53BP1_uc010udp.1_Missense_Mutation_p.D1301A|TP53BP1_uc001zrq.3_Missense_Mutation_p.D1306A|TP53BP1_uc001zrr.3_Missense_Mutation_p.D1306A|TP53BP1_uc010udq.1_Missense_Mutation_p.D1306A	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1301					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GGAGCTGATATCCCCCAGGTC	0.532000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes				
CYP19A1	1588	broad.mit.edu	37	15	51514616	51514616	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:51514616G>A	uc001zyz.3	-	6	809	c.558C>T	c.(556-558)GAC>GAT	p.D186D	CYP19A1_uc001zza.3_Silent_p.D186D|CYP19A1_uc001zzb.2_Silent_p.D186D|CYP19A1_uc001zzd.2_Silent_p.D186D|CYP19A1_uc010bey.1_Silent_p.D186D	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	186					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	GGGTCAACACGTCCACATAGC	0.517000												
TLN2	83660	broad.mit.edu	37	15	63069014	63069014	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:63069014G>A	uc002alb.3	+	40	5419	c.5419G>A	c.(5419-5421)GCC>ACC	p.A1807T	TLN2_uc002alc.3_Missense_Mutation_p.A200T|TLN2_uc002ald.2_Missense_Mutation_p.A200T	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1807					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GATGAAGGAAGCCGTGGATGA	0.557000												
CILP	8483	broad.mit.edu	37	15	65489719	65489719	+	Nonsense_Mutation	SNP	G	G	A	rs150946463		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:65489719G>A	uc002aon.2	-	9	3086	c.2905C>T	c.(2905-2907)CGA>TGA	p.R969*		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	969					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TTGCGGGATCGCACATTCACT	0.562000												
C15orf44	81556	broad.mit.edu	37	15	65871779	65871779	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:65871779C>T	uc002apd.2	-	12	1860	c.1524G>A	c.(1522-1524)ACG>ACA	p.T508T	C15orf44_uc010uix.1_Silent_p.T544T|C15orf44_uc010uiz.1_Silent_p.T472T|C15orf44_uc010uja.1_Silent_p.T458T|C15orf44_uc010ujb.1_Silent_p.T429T|C15orf44_uc002ape.3_Silent_p.T508T|C15orf44_uc010uiy.1_Silent_p.T429T	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	508										ovary(1)	1						CAGAGAAGTCCGTGTGCAAAG	0.473000												
C15orf44	81556	broad.mit.edu	37	15	65891302	65891302	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:65891302G>A	uc002apd.2	-	5	849	c.513C>T	c.(511-513)TGC>TGT	p.C171C	C15orf44_uc010uix.1_Silent_p.C207C|C15orf44_uc010uiz.1_Silent_p.C135C|C15orf44_uc010uja.1_Silent_p.C122C|C15orf44_uc010ujb.1_Silent_p.C92C|C15orf44_uc002ape.3_Silent_p.C171C|C15orf44_uc010uiy.1_Silent_p.C92C	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	171	VWFA.									ovary(1)	1						GACGTTCAAGGCATTCCAAGG	0.428000												
FEM1B	10116	broad.mit.edu	37	15	68582994	68582994	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:68582994T>C	uc002arg.2	+	2	1913	c.1298T>C	c.(1297-1299)GTC>GCC	p.V433A	FEM1B_uc002arh.2_Missense_Mutation_p.V353A	NM_015322	NP_056137	Q9UK73	FEM1B_HUMAN	fem-1 homolog b	433					apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity				0						GATGCTGATGTCCACAATGCT	0.373000												
THSD4	79875	broad.mit.edu	37	15	72020961	72020961	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:72020961C>T	uc002atb.1	+	8	1510	c.1431C>T	c.(1429-1431)GGC>GGT	p.G477G	THSD4_uc002atd.1_Silent_p.G151G|THSD4_uc010ukg.1_Silent_p.G117G|THSD4_uc002ate.2_Silent_p.G117G	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	477						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						AATACGAGGGCGGAGGGACCA	0.502000												
GOLGA6B	55889	broad.mit.edu	37	15	72956779	72956779	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:72956779G>A	uc010uks.1	+	13	1469	c.1428G>A	c.(1426-1428)GAG>GAA	p.E476E	uc002aux.1_5'Flank	NM_018652	NP_061122	A6NDN3	GOG6B_HUMAN	golgi autoantigen, golgin subfamily a, 6B	476	Potential.										0						CCCCTTAGGAGCACCTAGAAG	0.622000												
PML	5371	broad.mit.edu	37	15	74315644	74315644	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:74315644C>T	uc002awv.2	+	3	1218	c.1078C>T	c.(1078-1080)CGC>TGC	p.R360C	PML_uc002awm.2_Missense_Mutation_p.R360C|PML_uc002awl.2_Missense_Mutation_p.R360C|PML_uc002awj.1_Missense_Mutation_p.R360C|PML_uc002awk.2_Missense_Mutation_p.R360C|PML_uc002awn.2_Missense_Mutation_p.R360C|PML_uc002awo.2_Missense_Mutation_p.R360C|PML_uc002awp.2_Missense_Mutation_p.R360C|PML_uc002awq.2_Missense_Mutation_p.R360C|PML_uc002awr.2_Missense_Mutation_p.R360C|PML_uc002aws.2_Missense_Mutation_p.R360C|PML_uc002awt.2_Missense_Mutation_p.R360C|PML_uc002awu.2_Missense_Mutation_p.R360C|PML_uc010ule.1_Intron|PML_uc002aww.1_Missense_Mutation_p.R275C|PML_uc002awx.2_Missense_Mutation_p.R118C|PML_uc002awy.2_5'Flank	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	360					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						CTGCCGCCTGCGCCAGGAGGA	0.677000			T	RARA|PAX5	APL|ALL							
SIN3A	25942	broad.mit.edu	37	15	75693198	75693198	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:75693198C>A	uc002bai.2	-	11	1869	c.1610G>T	c.(1609-1611)CGA>CTA	p.R537L	SIN3A_uc002baj.2_Missense_Mutation_p.R537L|SIN3A_uc010uml.1_Missense_Mutation_p.R537L	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	537	Interactions with SUDS3 and SAP130.|Interaction with NCOR1 (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						CTCTGTGGCTCGCTCCTTTGG	0.428000												
AKAP13	11214	broad.mit.edu	37	15	86261259	86261259	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:86261259A>G	uc002blv.1	+	22	6040	c.5870A>G	c.(5869-5871)GAA>GGA	p.E1957G	AKAP13_uc002blu.1_Missense_Mutation_p.E1961G|AKAP13_uc010bnf.1_Missense_Mutation_p.E578G|AKAP13_uc002blw.1_Missense_Mutation_p.E422G|AKAP13_uc002blx.1_Missense_Mutation_p.E202G	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1957	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GACATGAATGAAGGACAACTA	0.383000												
HAPLN3	145864	broad.mit.edu	37	15	89424594	89424594	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:89424594G>T	uc002bnc.2	-	3	615	c.487C>A	c.(487-489)CTG>ATG	p.L163M	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Missense_Mutation_p.L225M	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	163	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					TCACCCCGCAGCTCCAGCTCC	0.557000												
C15orf42	90381	broad.mit.edu	37	15	90125982	90125982	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:90125982C>T	uc002boe.2	+	2	720	c.720C>T	c.(718-720)GGC>GGT	p.G240G		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	240					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			ACGGAGGTGGCACTGTCTTGC	0.463000												
MAN2A2	4122	broad.mit.edu	37	15	91454123	91454123	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:91454123G>T	uc010bnz.2	+	12	1922	c.1807G>T	c.(1807-1809)GCC>TCC	p.A603S	MAN2A2_uc010boa.2_Missense_Mutation_p.A645S|MAN2A2_uc002bqc.2_Missense_Mutation_p.A603S|MAN2A2_uc010uql.1_Missense_Mutation_p.A265S|MAN2A2_uc010uqm.1_Missense_Mutation_p.A182S|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	603	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CATTCATGCAGCCCACTATCT	0.592000												
RPUSD1	113000	broad.mit.edu	37	16	836929	836929	+	Splice_Site	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:836929C>A	uc002cka.2	-	4	644	c.410_splice	c.e4-1	p.G137_splice	RPUSD1_uc002ckb.2_Splice_Site_p.G137_splice|RPUSD1_uc002ckc.2_Splice_Site_p.G8_splice|RPUSD1_uc002ckd.2_Splice_Site_p.V103_splice|CHTF18_uc010uus.1_5'Flank|CHTF18_uc010bre.1_5'Flank|CHTF18_uc002cke.3_5'Flank|CHTF18_uc002ckf.3_5'Flank|CHTF18_uc010brf.2_5'Flank|CHTF18_uc002ckg.3_5'Flank	NM_058192	NP_478072	Q9UJJ7	RUSD1_HUMAN	RNA pseudouridylate synthase domain containing						pseudouridine synthesis		pseudouridine synthase activity|RNA binding				0		Hepatocellular(780;0.00335)				TTCTCACAACCTGGGGCGCAG	0.652000												
CCNF	899	broad.mit.edu	37	16	2499405	2499405	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:2499405C>T	uc002cqd.1	+	12	1429	c.1341C>T	c.(1339-1341)TAC>TAT	p.Y447Y	CCNF_uc002cqe.1_Silent_p.Y139Y	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	447					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				TGTCCGCCTACGCCCCAGCCC	0.672000												
CPPED1	55313	broad.mit.edu	37	16	12875064	12875064	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:12875064G>A	uc002dca.3	-	2	378	c.267C>T	c.(265-267)GGC>GGT	p.G89G	CPPED1_uc002dcb.3_Silent_p.G89G	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	89							hydrolase activity|metal ion binding				0						GGATGAGGTCGCCGCACAGAA	0.527000												
ABCC1	4363	broad.mit.edu	37	16	16218650	16218650	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:16218650C>T	uc010bvi.2	+	25	3770	c.3595C>T	c.(3595-3597)CTG>TTG	p.L1199L	ABCC1_uc010bvj.2_Silent_p.L1140L|ABCC1_uc010bvk.2_Silent_p.L1143L|ABCC1_uc010bvl.2_Silent_p.L1199L|ABCC1_uc010bvm.2_Silent_p.L1084L|ABCC1_uc002del.3_Silent_p.L1093L	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1199	Cytoplasmic.|ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GCGCAGGTGGCTGGCCGTGCG	0.582000												
VWA3A	146177	broad.mit.edu	37	16	22144335	22144335	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:22144335G>A	uc010vbq.1	+	20	2083	c.1987G>A	c.(1987-1989)GCC>ACC	p.A663T	VWA3A_uc010bxd.2_RNA|VWA3A_uc010bxc.2_Missense_Mutation_p.A671T	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	663	VWFA 1.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		TGCCCGCTATGCCAGTCACAC	0.612000												
TNRC6A	27327	broad.mit.edu	37	16	24802619	24802619	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:24802619G>A	uc002dmm.2	+	6	2770	c.2656G>A	c.(2656-2658)GGT>AGT	p.G886S	TNRC6A_uc010bxs.2_Missense_Mutation_p.G633S|TNRC6A_uc010vcc.1_Missense_Mutation_p.G633S|TNRC6A_uc002dmn.2_Missense_Mutation_p.G633S|TNRC6A_uc002dmo.2_Missense_Mutation_p.G633S	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	886	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GTCCGTTTCCGGTTGGAACGA	0.433000												
ZNF629	23361	broad.mit.edu	37	16	30794465	30794465	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:30794465G>A	uc002dzs.1	-	3	1392	c.1184C>T	c.(1183-1185)ACG>ATG	p.T395M		NM_001080417	NP_001073886	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	395	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			GCCCGTGTGCGTGCGCTGGTG	0.662000												
N4BP1	9683	broad.mit.edu	37	16	48594880	48594880	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:48594880G>A	uc002efp.2	-	2	1911	c.1674C>T	c.(1672-1674)TGC>TGT	p.C558C		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	558					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				AAAGGGTTGAGCAATTTGGCT	0.453000												
CBLN1	869	broad.mit.edu	37	16	49315161	49315161	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:49315161G>A	uc002efq.2	-	1	555	c.216C>T	c.(214-216)CAC>CAT	p.H72H		NM_004352	NP_004343	P23435	CBLN1_HUMAN	cerebellin 1 precursor	72	C1q.|Necessary for interaction with CBLN3, and homotrimerization (By similarity).				nervous system development|synaptic transmission	cell junction|extracellular region|synapse					0		all_cancers(37;0.0766)|all_lung(18;0.24)				CGGACGGCTCGTGGTTGGTGC	0.612000												
CHD9	80205	broad.mit.edu	37	16	53191220	53191220	+	Missense_Mutation	SNP	G	G	A	rs147266259	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:53191220G>A	uc002ehb.2	+	1	1383	c.1219G>A	c.(1219-1221)GAG>AAG	p.E407K	CHD9_uc002egy.2_Missense_Mutation_p.E407K|CHD9_uc002egz.1_Missense_Mutation_p.E407K|CHD9_uc002eha.1_Missense_Mutation_p.E407K|CHD9_uc002ehc.2_Missense_Mutation_p.E407K	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	407					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ACTTGACCCCGAGGACCTCCT	0.403000												
C16orf80	29105	broad.mit.edu	37	16	58149340	58149340	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:58149340G>A	uc002enb.1	-	4	575	c.298C>T	c.(298-300)CGT>TGT	p.R100C		NM_013242	NP_037374	Q9Y6A4	CP080_HUMAN	transcription factor IIB	100					multicellular organismal development						0						AAGCGACGACGCACATTCTTG	0.512000												
DPEP3	64180	broad.mit.edu	37	16	68013621	68013621	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:68013621A>G	uc002evc.3	-	2	504	c.410T>C	c.(409-411)CTT>CCT	p.L137P	DPEP3_uc010cex.2_Missense_Mutation_p.L137P	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	112					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		AACATCCTGAAGCACATTCTT	0.557000												
DUS2L	54920	broad.mit.edu	37	16	68110548	68110548	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:68110548G>A	uc002evi.2	+	15	1245	c.1096G>A	c.(1096-1098)GCC>ACC	p.A366T	DUS2L_uc002evj.2_Missense_Mutation_p.A366T|DUS2L_uc010vkk.1_Missense_Mutation_p.A331T|DUS2L_uc010cez.2_Missense_Mutation_p.A279T	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	366					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		AGCATACCCAGCCCAGATCAC	0.597000												
WWP2	11060	broad.mit.edu	37	16	69964094	69964094	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:69964094C>T	uc002exu.1	+	14	1467	c.1378C>T	c.(1378-1380)CGA>TGA	p.R460*	WWP2_uc002exv.1_Nonsense_Mutation_p.R460*|WWP2_uc010vlm.1_Nonsense_Mutation_p.R344*|WWP2_uc010vln.1_Nonsense_Mutation_p.R78*|WWP2_uc002exw.1_Nonsense_Mutation_p.R21*|uc002exx.1_5'Flank|MIR140_hsa-mir-140|MI0000456_5'Flank	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	460	WW 4.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						CGAGGGGGTGCGATACTTTGT	0.572000											OREG0023910	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
MTSS1L	92154	broad.mit.edu	37	16	70708342	70708342	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:70708342T>C	uc002ezj.2	-	11	1180	c.920A>G	c.(919-921)TAC>TGC	p.Y307C		NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	307	Ser-rich.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						CAGGCTGCGGTAGCGACAGGT	0.662000												
PMFBP1	83449	broad.mit.edu	37	16	72158677	72158677	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:72158677C>T	uc002fcc.3	-	17	2765	c.2593G>A	c.(2593-2595)GAC>AAC	p.D865N	PMFBP1_uc002fcd.2_Missense_Mutation_p.D860N|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.D715N|PMFBP1_uc010cgo.1_Missense_Mutation_p.D156N	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	865	Potential.									ovary(2)	2		Ovarian(137;0.179)				TCCTTATCGTCCTCAAGGAGG	0.572000											OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
MLYCD	23417	broad.mit.edu	37	16	83933108	83933108	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:83933108C>T	uc002fgz.2	+	1	379	c.359C>T	c.(358-360)GCG>GTG	p.A120V		NM_012213	NP_036345	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase precursor	120					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity				0						CGGGAGGCGGCGGTGCTGCTG	0.746000												
SLC38A8	146167	broad.mit.edu	37	16	84050219	84050219	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:84050219G>A	uc002fhg.1	-	8	1067	c.1067C>T	c.(1066-1068)ACC>ATC	p.T356I		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	356	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						GAGCGTCACGGTGACCCACAG	0.627000												
ATP2C2	9914	broad.mit.edu	37	16	84485577	84485577	+	Missense_Mutation	SNP	C	C	A	rs146513346	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:84485577C>A	uc002fhx.2	+	18	1800	c.1711C>A	c.(1711-1713)CTT>ATT	p.L571I	ATP2C2_uc010chj.2_Missense_Mutation_p.L571I|ATP2C2_uc002fhy.2_Missense_Mutation_p.L588I|ATP2C2_uc002fhz.2_Missense_Mutation_p.L420I	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	571	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						GTTTCTCGGTCTTGTGGGCAT	0.627000												
COX4I1	1327	broad.mit.edu	37	16	85839401	85839401	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:85839401A>G	uc002fje.2	+	4	468	c.304A>G	c.(304-306)ACG>GCG	p.T102A	COX4I1_uc002fjf.2_3'UTR|COX4I1_uc002fjg.1_Missense_Mutation_p.T102A|COX4I1_uc010vom.1_Missense_Mutation_p.T69A	NM_001861	NP_001852	P13073	COX41_HUMAN	cytochrome c oxidase subunit IV isoform 1	102					respiratory electron transport chain	mitochondrial inner membrane|nucleus	cytochrome-c oxidase activity|protein binding			lung(1)	1		Renal(780;0.228)				CGAGTGGAAGACGGTTGTGGG	0.547000												
ANKRD11	29123	broad.mit.edu	37	16	89350965	89350965	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:89350965T>C	uc002fmx.1	-	9	2446	c.1985A>G	c.(1984-1986)GAG>GGG	p.E662G	ANKRD11_uc002fmy.1_Missense_Mutation_p.E662G|ANKRD11_uc002fnc.1_Missense_Mutation_p.E662G|ANKRD11_uc002fnb.1_Missense_Mutation_p.E619G	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	662	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTTGGAGTCCTCATATTCGTA	0.373000												
RPA1	6117	broad.mit.edu	37	17	1783866	1783866	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:1783866C>T	uc002fto.2	+	12	1237	c.1122C>T	c.(1120-1122)CCC>CCT	p.P374P		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	374					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						CTAGACAGCCCGTGTTGGCTA	0.453000								NER				
PITPNM3	83394	broad.mit.edu	37	17	6376029	6376029	+	Silent	SNP	G	G	A	rs143785279		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:6376029G>A	uc002gdd.3	-	11	1528	c.1377C>T	c.(1375-1377)AGC>AGT	p.S459S	PITPNM3_uc010cln.2_Silent_p.S423S|PITPNM3_uc010clm.2_5'UTR|PITPNM3_uc002gdc.3_Silent_p.S50S	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	459	DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		AGCGAGGCACGCTGACAGGCG	0.652000												
DNAH2	146754	broad.mit.edu	37	17	7707688	7707688	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:7707688G>T	uc002giu.1	+	58	9101	c.9087G>T	c.(9085-9087)GAG>GAT	p.E3029D	DNAH2_uc010cnm.1_Missense_Mutation_p.E6D	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3029	Potential.|Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGGAGCTGGAGGATGCCAAGA	0.542000												
KDM6B	23135	broad.mit.edu	37	17	7753402	7753402	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:7753402C>T	uc002giw.1	+	13	3956	c.3580C>T	c.(3580-3582)CGG>TGG	p.R1194W	KDM6B_uc002gix.2_Missense_Mutation_p.R496W	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	1194					inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						GGAGAGCAAACGGGATGCCTT	0.607000												
ARHGEF15	22899	broad.mit.edu	37	17	8216372	8216372	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:8216372G>A	uc002glc.2	+	3	855	c.734G>A	c.(733-735)CGG>CAG	p.R245Q	ARHGEF15_uc002glb.1_3'UTR|ARHGEF15_uc002gld.2_Missense_Mutation_p.R245Q|ARHGEF15_uc010vuw.1_Intron	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	245					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TCCCCGCTGCGGACCTCTCGC	0.687000												
ARHGEF15	22899	broad.mit.edu	37	17	8218457	8218457	+	Silent	SNP	T	T	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:8218457T>G	uc002glc.2	+	6	1243	c.1122T>G	c.(1120-1122)CCT>CCG	p.P374P	ARHGEF15_uc002gld.2_Silent_p.P374P|ARHGEF15_uc010vuw.1_Silent_p.P263P	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	374					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						ATGGGAGTCCTTCTCCAGCAA	0.612000												
MFSD6L	162387	broad.mit.edu	37	17	8701217	8701217	+	Missense_Mutation	SNP	C	C	T	rs143056359	byFrequency	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:8701217C>T	uc002glp.1	-	1	1370	c.1222G>A	c.(1222-1224)GCC>ACC	p.A408T		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	408	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						AAGCTGAGGGCGACCGAGAAA	0.562000												
CDRT15	146822	broad.mit.edu	37	17	14139301	14139301	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:14139301G>A	uc010vvu.1	-	3	439	c.439C>T	c.(439-441)CTG>TTG	p.L147L	CDRT15_uc010coq.2_RNA	NM_001007530	NP_001007531	Q96T59	CDRTF_HUMAN	CMT1A duplicated region transcript 15	147											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		CTTCTTCCCAGCCTTCTTTTA	0.567000												
SSH2	85464	broad.mit.edu	37	17	27958581	27958581	+	Missense_Mutation	SNP	C	C	T	rs144293105	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:27958581C>T	uc002heo.1	-	15	3550	c.3550G>A	c.(3550-3552)GCA>ACA	p.A1184T	SSH2_uc010wbh.1_Missense_Mutation_p.A1211T	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1184					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						CTTAGGTCTGCGCTACTTAGC	0.507000												
MMP28	79148	broad.mit.edu	37	17	34094866	34094866	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:34094866T>A	uc002hjy.1	-	9	1332	c.1073A>T	c.(1072-1074)GAG>GTG	p.E358V	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	358	Hemopexin-like 1.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGGACGGGGCTCTGAGACGTT	0.522000												
CCL23	6368	broad.mit.edu	37	17	34340329	34340329	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:34340329G>A	uc002hkt.1	-	4	342	c.271C>T	c.(271-273)CGA>TGA	p.R91*	CCL23_uc002hks.1_Nonsense_Mutation_p.R108*	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	91					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CAGAAACGTCGCCCCTTCTTG	0.532000												
ERBB2	2064	broad.mit.edu	37	17	37879658	37879658	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:37879658G>A	uc002hso.2	+	17	2271	c.2033G>A	c.(2032-2034)CGG>CAG	p.R678Q	ERBB2_uc002hsm.2_Missense_Mutation_p.R648Q|ERBB2_uc010cwa.2_Missense_Mutation_p.R663Q|ERBB2_uc002hsp.2_Missense_Mutation_p.R481Q|ERBB2_uc010cwb.2_Missense_Mutation_p.R678Q|ERBB2_uc010wek.1_Missense_Mutation_p.R402Q	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	678	Cytoplasmic (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ATCAAGCGACGGCAGCAGAAG	0.637000		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)		
KRT32	3882	broad.mit.edu	37	17	39623484	39623484	+	Missense_Mutation	SNP	G	G	A	rs149170177	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:39623484G>A	uc002hwr.2	-	1	155	c.94C>T	c.(94-96)CGG>TGG	p.R32W		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	32	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)				AGCTCAGGCCGGCAGTTCACG	0.632000												
SOST	50964	broad.mit.edu	37	17	41832889	41832889	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:41832889G>A	uc002iec.1	-	2	510	c.463C>T	c.(463-465)CGC>TGC	p.R155C		NM_025237	NP_079513	Q9BQB4	SOST_HUMAN	sclerostin precursor	155	CTCK.				negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of ossification|negative regulation of protein complex assembly|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway		heparin binding|protein binding				0		Breast(137;0.00725)		UCEC - Uterine corpus endometrioid carcinoma (308;0.177)|BRCA - Breast invasive adenocarcinoma(366;0.0741)		TTGCGCGCGCGCGGCGCCTCA	0.711000												
HOXB9	3219	broad.mit.edu	37	17	46703515	46703515	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:46703515C>T	uc002inx.2	-	1	321	c.117G>A	c.(115-117)CCG>CCA	p.P39P		NM_024017	NP_076922	P17482	HXB9_HUMAN	homeobox B9	39					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCGCGTGGCCCGGCTGCCGCG	0.662000												
MYCBPAP	84073	broad.mit.edu	37	17	48603504	48603504	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:48603504G>A	uc010wmr.1	+	14	2336	c.2174G>A	c.(2173-2175)CGG>CAG	p.R725Q	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	688					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			AGTCCTCAGCGGAAGAGCATC	0.627000												
FTSJ3	117246	broad.mit.edu	37	17	61899365	61899365	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:61899365T>C	uc002jbz.2	-	13	1532	c.1454A>G	c.(1453-1455)CAG>CGG	p.Q485R	FTSJ3_uc002jca.2_Missense_Mutation_p.Q485R	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	485					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						CCTTAGACCCTGATGTCCCCT	0.537000												
APCDD1	147495	broad.mit.edu	37	18	10487790	10487790	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:10487790C>T	uc002kom.3	+	5	1654	c.1300C>T	c.(1300-1302)CGC>TGC	p.R434C		NM_153000	NP_694545	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	434	Extracellular (Potential).				hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding				0				READ - Rectum adenocarcinoma(15;0.08)		TGCCCGGGGGCGCTATCTGCT	0.602000												
CEP192	55125	broad.mit.edu	37	18	13069103	13069103	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:13069103G>A	uc010xac.1	+	26	5058	c.4978G>A	c.(4978-4980)GCC>ACC	p.A1660T	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.A1185T|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.A82T|CEP192_uc002krw.2_5'Flank	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	1660										ovary(4)|pancreas(1)	5						GCATTTCTTGGCCAAAGTGGC	0.438000												
C18orf19	125228	broad.mit.edu	37	18	13671878	13671878	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:13671878C>T	uc010dlh.2	-	4	1000	c.568G>A	c.(568-570)GCA>ACA	p.A190T	C18orf19_uc010dlg.2_Intron|C18orf19_uc010dli.2_Missense_Mutation_p.A190T|C18orf19_uc002ksj.3_Missense_Mutation_p.A190T|C18orf19_uc010dlj.2_Intron	NM_001098801	NP_001092271	Q96ND0	CR019_HUMAN	hypothetical protein LOC125228	190	DUF1279.					integral to membrane				breast(2)	2						AAGGCATATGCTGTGAGGGCA	0.458000												
KCTD1	284252	broad.mit.edu	37	18	24035755	24035755	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:24035755C>T	uc002kvw.2	-	5	1286	c.726G>A	c.(724-726)ACG>ACA	p.T242T	KCTD1_uc010xbj.1_Silent_p.T850T|KCTD1_uc010xbk.1_Silent_p.T242T|KCTD1_uc002kvy.2_3'UTR	NM_001136205	NP_001129677	Q719H9	KCTD1_HUMAN	potassium channel tetramerisation domain	242					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			GTACACGGGGCGTCCGCCTCA	0.507000												
CDH2	1000	broad.mit.edu	37	18	25572682	25572682	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:25572682A>G	uc002kwg.2	-	9	1740	c.1281T>C	c.(1279-1281)CCT>CCC	p.P427P	CDH2_uc010xbn.1_Silent_p.P396P	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	427	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						ACCGTCCAGTAGGATCTCCGC	0.522000												
C18orf34	374864	broad.mit.edu	37	18	30554568	30554568	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:30554568C>T	uc002kxn.2	-	21	2608	c.2466G>A	c.(2464-2466)AGG>AGA	p.R822R	C18orf34_uc010xbq.1_RNA|C18orf34_uc010dme.1_Silent_p.R286R|C18orf34_uc010xbr.1_Silent_p.R846R|C18orf34_uc010dmf.1_Silent_p.R142R|C18orf34_uc002kxo.2_Silent_p.R784R|C18orf34_uc002kxp.2_Silent_p.R822R	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	822										ovary(1)	1						AGTTGGCCAGCCTCATCTGGC	0.498000												
SLC14A2	8170	broad.mit.edu	37	18	43262295	43262295	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:43262295G>A	uc010dnj.2	+	21	2895	c.2574G>A	c.(2572-2574)CCG>CCA	p.P858P	SLC14A2_uc002lbe.2_Silent_p.P858P	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	858	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TTGGATTGCCGCCCTGCACTT	0.532000												
DOK6	220164	broad.mit.edu	37	18	67425047	67425047	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:67425047G>A	uc002lkl.2	+	7	984	c.794G>A	c.(793-795)CGC>CAC	p.R265H		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	265	DKFBH motif.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				TCTCTTCCTCGCAGCGCGTAC	0.398000												
GALR1	2587	broad.mit.edu	37	18	74963015	74963015	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:74963015G>A	uc002lms.3	+	1	1008	c.511G>A	c.(511-513)GCC>ACC	p.A171T		NM_001480	NP_001471	P47211	GALR1_HUMAN	galanin receptor 1	171	Helical; Name=4; (Potential).				digestion|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity			lung(1)	1		Prostate(75;0.0865)|Esophageal squamous(42;0.129)|Melanoma(33;0.211)		OV - Ovarian serous cystadenocarcinoma(15;1.03e-06)|BRCA - Breast invasive adenocarcinoma(31;0.104)		CTCGCCCGTGGCCTACCACCA	0.697000												
SALL3	27164	broad.mit.edu	37	18	76757125	76757125	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr18:76757125G>A	uc002lmt.2	+	3	3706	c.3706G>A	c.(3706-3708)GGC>AGC	p.G1236S	SALL3_uc010dra.2_Missense_Mutation_p.G771S	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1236					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CATCCAGAACGGCGGCATCCC	0.617000												
C19orf28	126321	broad.mit.edu	37	19	3546376	3546376	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:3546376C>A	uc002lxz.2	-	7	1241	c.1071G>T	c.(1069-1071)TGG>TGT	p.W357C	C19orf28_uc002lxw.2_Missense_Mutation_p.W357C|C19orf28_uc002lxx.2_Missense_Mutation_p.W357C|C19orf28_uc002lxy.2_Missense_Mutation_p.W348C	NM_174983	NP_778148	Q6NUT3	CS028_HUMAN	hypothetical protein LOC126321 isoform c	357	Helical; (Potential).				transmembrane transport	integral to membrane				breast(1)|pancreas(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00251)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGCGCCACCCAGGCGGCAA	0.687000												
PLIN4	729359	broad.mit.edu	37	19	4504766	4504766	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:4504766C>T	uc002mar.1	-	6	3779	c.3779G>A	c.(3778-3780)TGC>TAC	p.C1260Y	PLIN4_uc010dub.1_Missense_Mutation_p.C284Y	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	1260						lipid particle|plasma membrane					0						GAGAAGGCCGCAGACCCTGGA	0.721000												
PTPRS	5802	broad.mit.edu	37	19	5240270	5240270	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:5240270C>T	uc002mbv.2	-	12	1878	c.1644G>A	c.(1642-1644)CCG>CCA	p.P548P	PTPRS_uc002mbu.1_Silent_p.P535P|PTPRS_uc010xin.1_Silent_p.P535P|PTPRS_uc002mbw.2_Silent_p.P535P|PTPRS_uc002mbx.2_Silent_p.P539P|PTPRS_uc002mby.2_Silent_p.P535P	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	548	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TCTCCTGCCGCGGGGGGCTCC	0.697000												
SH2D3A	10045	broad.mit.edu	37	19	6760769	6760769	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:6760769C>T	uc002mft.2	-	3	493	c.299G>A	c.(298-300)CGC>CAC	p.R100H	SH2D3A_uc010xjg.1_Intron	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	100	SH2.				JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						GGACAGTGGGCGCCTGCCTGT	0.632000												
EMR1	2015	broad.mit.edu	37	19	6924840	6924840	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:6924840C>T	uc002mfw.2	+	15	1981	c.1943C>T	c.(1942-1944)GCG>GTG	p.A648V	EMR1_uc010dvc.2_Intron|EMR1_uc010dvb.2_Missense_Mutation_p.A596V|EMR1_uc010xji.1_Missense_Mutation_p.A507V|EMR1_uc010xjj.1_Missense_Mutation_p.A471V	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	648	Helical; Name=2; (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					CTCCTCTTGGCGAAGACTCTC	0.493000												
PNPLA6	10908	broad.mit.edu	37	19	7607530	7607530	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:7607530G>A	uc010xjq.1	+	13	1558	c.1363G>A	c.(1363-1365)GGG>AGG	p.G455R	PNPLA6_uc002mgq.1_Missense_Mutation_p.G407R|PNPLA6_uc010xjp.1_Missense_Mutation_p.G407R|PNPLA6_uc002mgr.1_Missense_Mutation_p.G407R|PNPLA6_uc002mgs.2_Missense_Mutation_p.G446R	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	446	Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						AGAGGCCTCCGGGGGGTCCCT	0.706000												
MUC16	94025	broad.mit.edu	37	19	9085173	9085173	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:9085173A>G	uc002mkp.2	-	1	6846	c.6642T>C	c.(6640-6642)AAT>AAC	p.N2214N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2214	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTGTTTCTGTATTAGTAGTTG	0.473000												
MUC16	94025	broad.mit.edu	37	19	9090794	9090794	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:9090794C>T	uc002mkp.2	-	1	1225	c.1021G>A	c.(1021-1023)GAA>AAA	p.E341K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	341	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGACCCTTTCGGCACTTGTT	0.522000												
LPPR2	64748	broad.mit.edu	37	19	11468409	11468409	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:11468409C>T	uc002mre.1	+	3	397	c.60C>T	c.(58-60)TTC>TTT	p.F20F	LPPR2_uc002mrf.1_Silent_p.F20F|LPPR2_uc010dxy.1_5'Flank	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	20	Helical; (Potential).					integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						GCTTTGTCTTCGTGGAGGTGA	0.582000												
BRD4	23476	broad.mit.edu	37	19	15383896	15383896	+	Silent	SNP	G	G	A	rs147477529		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:15383896G>A	uc002nar.2	-	2	237	c.15C>T	c.(13-15)AGC>AGT	p.S5S	BRD4_uc002nas.2_Silent_p.S5S|BRD4_uc002nat.3_Silent_p.S5S|BRD4_uc002nau.3_Silent_p.S5S	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	5					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TCCCAGGGCCGCTCTCCGCAG	0.547000			T	NUT|C15orf55	lethal midline carcinoma of young people							
CIB3	117286	broad.mit.edu	37	19	16284237	16284237	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:16284237T>C	uc002nds.2	-	1	50	c.50A>G	c.(49-51)CAG>CGG	p.Q17R	CIB3_uc010eae.2_5'UTR|CIB3_uc010eaf.2_RNA|CIB3_uc010eag.2_Missense_Mutation_p.Q17R	NM_054113	NP_473454	Q96Q77	CIB3_HUMAN	DNA-dependent protein kinase catalytic	17							calcium ion binding			ovary(1)	1						CCCCTCTACCTGATACGCTTC	0.567000												
PIK3R2	5296	broad.mit.edu	37	19	18273240	18273240	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:18273240C>T	uc002nia.1	+	9	1545	c.1033C>T	c.(1033-1035)CGG>TGG	p.R345W	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	345	SH2 1.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						CGAGAAACTCCGGGACACTCC	0.612000												
NCAN	1463	broad.mit.edu	37	19	19337381	19337381	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:19337381G>A	uc002nlz.2	+	7	1258	c.1159G>A	c.(1159-1161)GTT>ATT	p.V387I	NCAN_uc010ecc.1_5'UTR	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	387					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GGGGCCCCCAGTTAGAGAACT	0.582000												
CILP2	148113	broad.mit.edu	37	19	19656302	19656302	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:19656302G>A	uc002nmv.3	+	8	3033	c.2948G>A	c.(2947-2949)CGT>CAT	p.R983H	CILP2_uc002nmw.3_Missense_Mutation_p.R989H	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	983						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GACCCCGAGCGTCCGGGCACC	0.677000												
GMIP	51291	broad.mit.edu	37	19	19746260	19746260	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:19746260G>A	uc002nnd.2	-	15	1641	c.1524C>T	c.(1522-1524)TGC>TGT	p.C508C	GMIP_uc010xrb.1_Silent_p.C482C|GMIP_uc010xrc.1_Silent_p.C479C	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	508	Phorbol-ester/DAG-type.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						TGAAGGCTTCGCACTCGCGGC	0.622000												
ZNF85	7639	broad.mit.edu	37	19	21117776	21117776	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:21117776A>C	uc002npg.3	+	3	279	c.152A>C	c.(151-153)GAC>GCC	p.D51A	ZNF85_uc002npf.2_RNA|ZNF85_uc002nph.1_RNA|ZNF85_uc010ecn.2_Intron|ZNF85_uc010eco.2_5'Flank|ZNF85_uc002npi.2_5'Flank	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	51	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						TCTAAGCCAGACCTGATCACT	0.368000												
GAPDHS	26330	broad.mit.edu	37	19	36033284	36033284	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:36033284C>T	uc002oaf.1	+	5	629	c.513C>T	c.(511-513)GGC>GGT	p.G171G	uc010eec.1_Intron|uc002oag.2_Intron	NM_014364	NP_055179	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase,	171					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding				0	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	AGTCCACAGGCGTGTACCTCT	0.637000												
ZNF567	163081	broad.mit.edu	37	19	37211245	37211245	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:37211245A>G	uc010xtl.1	+	6	1841	c.1619A>G	c.(1618-1620)AAG>AGG	p.K540R	ZNF567_uc002oeo.1_Missense_Mutation_p.K540R|ZNF567_uc010xtk.1_Missense_Mutation_p.K540R|ZNF567_uc002oep.3_Missense_Mutation_p.K509R|ZNF567_uc002oeq.1_Missense_Mutation_p.K509R	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	540	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GAATGTGGGAAGTCCTTTCGC	0.408000												
LGALS14	56891	broad.mit.edu	37	19	40197860	40197860	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:40197860T>C	uc002omg.2	+	3	358	c.135T>C	c.(133-135)GAT>GAC	p.D45D	LGALS14_uc002omf.2_Silent_p.D74D	NM_020129	NP_064514	Q8TCE9	PPL13_HUMAN	lectin, galactoside-binding, soluble, 14 isoform	45	Galectin.					nucleus	sugar binding			ovary(1)|skin(1)	2	all_cancers(60;4.39e-06)|all_lung(34;6.76e-08)|Lung NSC(34;7.98e-08)|Ovarian(47;0.06)	Myeloproliferative disorder(2;0.0741)	Epithelial(26;1.08e-24)|OV - Ovarian serous cystadenocarcinoma(5;1.92e-24)|all cancers(26;4.12e-22)			CTGGGATGGATGAGGACTCAG	0.488000												
FCGBP	8857	broad.mit.edu	37	19	40434210	40434210	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:40434210A>G	uc002omp.3	-	2	67	c.59T>C	c.(58-60)TTG>TCG	p.L20S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	20						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTCCTGGGTCAATCCTGGTTG	0.507000												
CIC	23152	broad.mit.edu	37	19	42791717	42791717	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:42791717G>A	uc002otf.1	+	5	643	c.603G>A	c.(601-603)CGG>CGA	p.R201R		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	201	HMG box.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				ACCACATCCGGCGGCCCATGA	0.622000			T	DUX4	soft tissue sarcoma							
BCAM	4059	broad.mit.edu	37	19	45317997	45317997	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:45317997C>T	uc002ozu.2	+	8	1102	c.1058C>T	c.(1057-1059)ACG>ATG	p.T353M	BCAM_uc002ozt.1_Missense_Mutation_p.T353M	NM_005581	NP_005572	P50895	BCAM_HUMAN	basal cell adhesion molecule isoform 1	353	Extracellular (Potential).|Ig-like C2-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			skin(1)	1	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CTCTCCAAGACGCTGGAGCTG	0.672000												
GEMIN7	79760	broad.mit.edu	37	19	45593386	45593386	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:45593386T>C	uc002pap.1	+	3	165	c.14T>C	c.(13-15)GTG>GCG	p.V5A	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Missense_Mutation_p.V5A|GEMIN7_uc002par.1_Missense_Mutation_p.V5A	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	5					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		CAAACTCCAGTGAACATTCCC	0.572000												
TRPM4	54795	broad.mit.edu	37	19	49713591	49713591	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:49713591G>A	uc002pmw.2	+	21	3329	c.3257G>A	c.(3256-3258)CGC>CAC	p.R1086H	TRPM4_uc010emu.2_Missense_Mutation_p.R941H|TRPM4_uc010yak.1_Missense_Mutation_p.R550H|TRPM4_uc002pmx.2_Missense_Mutation_p.R912H|TRPM4_uc010emv.2_Missense_Mutation_p.R971H|TRPM4_uc010yal.1_Missense_Mutation_p.R732H|TRPM4_uc002pmy.2_Missense_Mutation_p.R428H	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	1086	Cytoplasmic (Potential).|Calmodulin-binding.				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		TCCCACTTGCGCCTCCTGCTC	0.622000												
PRMT1	3276	broad.mit.edu	37	19	50185189	50185189	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:50185189G>A	uc010enf.1	+	4	257	c.215G>A	c.(214-216)CGC>CAC	p.R72H	PRMT1_uc002ppc.1_RNA|PRMT1_uc002ppd.2_Missense_Mutation_p.R48H|PRMT1_uc002ppe.2_Missense_Mutation_p.R54H|PRMT1_uc002ppf.2_RNA|PRMT1_uc002ppg.2_Missense_Mutation_p.R19H|PRMT1_uc010yba.1_RNA	NM_001536	NP_001527	Q8WUW5	Q8WUW5_HUMAN	HMT1 hnRNP methyltransferase-like 2 isoform 1	53						cytoplasm	protein methyltransferase activity			ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00103)|GBM - Glioblastoma multiforme(134;0.012)		GACGAGGTGCGCACCCTCACT	0.597000												
TSKS	60385	broad.mit.edu	37	19	50266392	50266392	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:50266392C>A	uc002ppm.2	-	1	124	c.113G>T	c.(112-114)AGG>ATG	p.R38M		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	38							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GCTGGTCACCCTCCGGGGAGC	0.622000												
PTOV1	53635	broad.mit.edu	37	19	50360277	50360277	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:50360277G>A	uc002pqf.1	+	6	774	c.604G>A	c.(604-606)GTG>ATG	p.V202M	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Missense_Mutation_p.V170M|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	202	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		TGAGGTGCGCGTGCTCATGCT	0.657000												
NR1H2	7376	broad.mit.edu	37	19	50882274	50882274	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:50882274G>A	uc010enw.2	+	8	1042	c.766G>A	c.(766-768)GCA>ACA	p.A256T	NR1H2_uc002prv.3_Intron|NR1H2_uc002prz.3_Intron|NR1H2_uc002psa.3_Missense_Mutation_p.A158T	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	255	Ligand-binding (Potential).				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GCCCCTGGGCGCAGACCCCCA	0.632000												
POLD1	5424	broad.mit.edu	37	19	50905604	50905604	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:50905604C>T	uc002psb.3	+	6	788	c.732C>T	c.(730-732)TAC>TAT	p.Y244Y	POLD1_uc002psc.3_Silent_p.Y244Y|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Silent_p.Y244Y	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	244					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		TCGCGCCCTACGAGGCCAACG	0.711000								DNA_polymerases_(catalytic_subunits)				
IGLON5	402665	broad.mit.edu	37	19	51826934	51826934	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:51826934C>T	uc002pwc.2	+	3	177	c.177C>T	c.(175-177)CAC>CAT	p.H59H		NM_001101372	NP_001094842	A6NGN9	IGLO5_HUMAN	IgLON family member 5 precursor	59	Ig-like C2-type 1.					extracellular region					0						TCGACGAGCACGTGACCCGCG	0.652000												
ZNF480	147657	broad.mit.edu	37	19	52825647	52825647	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:52825647C>T	uc010ydl.1	+	5	1214	c.1144C>T	c.(1144-1146)CAA>TAA	p.Q382*	ZNF480_uc002pyv.2_Nonsense_Mutation_p.Q305*|ZNF480_uc010ydm.1_Nonsense_Mutation_p.Q339*|ZNF480_uc010epn.2_Nonsense_Mutation_p.Q213*|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	382	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		GGTCTTTATTCAAAATTCGCA	0.363000												
EPN1	29924	broad.mit.edu	37	19	56203248	56203248	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:56203248C>T	uc002qlw.2	+	7	1233	c.891C>T	c.(889-891)GGC>GGT	p.G297G	EPN1_uc002qlv.2_Silent_p.G272G|EPN1_uc010etd.2_Silent_p.G297G|EPN1_uc002qlx.2_Silent_p.G383G	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	297	Ala/Gly/Pro-rich.|8 X 3 AA repeats of [ED]-P-W.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		ACCCCTGGGGCGGCCCCCCTG	0.761000												
NLRP5	126206	broad.mit.edu	37	19	56539649	56539649	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:56539649A>C	uc002qmj.2	+	7	2050	c.2050A>C	c.(2050-2052)ACC>CCC	p.T684P	NLRP5_uc002qmi.2_Missense_Mutation_p.T665P	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	684						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCCAGGAGACACCCTGGACGC	0.547000												
ZNF583	147949	broad.mit.edu	37	19	56935314	56935314	+	Silent	SNP	T	T	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:56935314T>G	uc010ygl.1	+	5	1452	c.1287T>G	c.(1285-1287)GTT>GTG	p.V429V	ZNF583_uc002qnc.2_Silent_p.V429V|ZNF583_uc010ygm.1_Silent_p.V429V	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	429	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		ATCAGAGGGTTCATACTGGAG	0.393000												
PQLC3	130814	broad.mit.edu	37	2	11315100	11315100	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:11315100T>C	uc002rbc.2	+	6	615	c.482T>C	c.(481-483)ATA>ACA	p.I161T	PQLC3_uc010yjk.1_Intron	NM_152391	NP_689604	Q8N755	PQLC3_HUMAN	PQ loop repeat containing 3 precursor	161						integral to membrane					0	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0978)|OV - Ovarian serous cystadenocarcinoma(76;0.132)		ACAGCAAGAATAATCACAACC	0.333000												
GREB1	9687	broad.mit.edu	37	2	11742628	11742628	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:11742628G>A	uc002rbk.1	+	17	2926	c.2626G>A	c.(2626-2628)GAT>AAT	p.D876N	GREB1_uc002rbo.1_Missense_Mutation_p.D510N	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	876						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GCTCAGATACGATAGCTCCTT	0.438000												
DNMT3A	1788	broad.mit.edu	37	2	25467502	25467502	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:25467502G>A	uc002rgc.2	-	14	1831	c.1574C>T	c.(1573-1575)GCG>GTG	p.A525V	DNMT3A_uc002rgd.2_Missense_Mutation_p.A525V|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.A336V	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	525	Interaction with the PRC2/EED-EZH2 complex (By similarity).|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTACTGGTACGCACACTCCAG	0.617000			Mis|F|N|S		AML							
FBXO11	80204	broad.mit.edu	37	2	48046138	48046138	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:48046138C>T	uc010fbl.2	-	15	1739	c.1625G>A	c.(1624-1626)AGC>AAC	p.S542N	FBXO11_uc002rwe.2_Missense_Mutation_p.S542N|FBXO11_uc002rwf.2_Missense_Mutation_p.S542N|FBXO11_uc002rwg.1_Missense_Mutation_p.S542N|FBXO11_uc010fbk.2_Missense_Mutation_p.S50N	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	626	PbH1 11.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TACTGGAGTGCTGCCAGTTGT	0.428000												
USP34	9736	broad.mit.edu	37	2	61430387	61430387	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:61430387G>A	uc002sbe.2	-	75	9418	c.9396C>T	c.(9394-9396)GAC>GAT	p.D3132D	USP34_uc002sbd.2_Intron	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3132					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GATCATAAACGTCATCTTTGC	0.313000												
HSPC159	29094	broad.mit.edu	37	2	64683599	64683599	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:64683599G>T	uc002scy.3	+	4	728	c.375G>T	c.(373-375)AGG>AGT	p.R125S		NM_014181	NP_054900	Q3ZCW2	LEGL_HUMAN	galectin-related protein	125	Galectin.					intracellular	sugar binding				0						AGCCATTCAGGGTGAGTACCT	0.502000												
FBXO41	150726	broad.mit.edu	37	2	73491512	73491512	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:73491512C>A	uc002sjb.1	-	6	1883	c.1883G>T	c.(1882-1884)CGC>CTC	p.R628L		NM_001080410	NP_001073879	Q8TF61	FBX41_HUMAN	F-box protein 41	567						intracellular	protein binding|zinc ion binding			breast(2)|pancreas(1)	3						CAGCAGTGTGCGCGTGTCCAG	0.632000												
MOGS	7841	broad.mit.edu	37	2	74689823	74689823	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:74689823C>T	uc010ffj.2	-	4	1256	c.1093G>A	c.(1093-1095)GCT>ACT	p.A365T	MOGS_uc010ffh.2_Missense_Mutation_p.A90T|MOGS_uc010yrt.1_Missense_Mutation_p.A246T|MOGS_uc010ffi.2_Missense_Mutation_p.A259T	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	365	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						AAGCCTTCAGCATGGCTCTCC	0.577000												
HTRA2	27429	broad.mit.edu	37	2	74760069	74760069	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:74760069G>A	uc002smi.1	+	8	1936	c.1334G>A	c.(1333-1335)CGA>CAA	p.R445Q	HTRA2_uc002smj.1_Missense_Mutation_p.R348Q|HTRA2_uc002smk.1_Missense_Mutation_p.R423Q|HTRA2_uc002sml.1_Missense_Mutation_p.R413Q|HTRA2_uc002smm.1_Missense_Mutation_p.R186Q|HTRA2_uc002smn.1_Missense_Mutation_p.R186Q|LOXL3_uc002smo.1_3'UTR|LOXL3_uc010ffm.1_3'UTR|LOXL3_uc002smp.1_3'UTR|LOXL3_uc002smq.1_3'UTR	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	445	PDZ.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						CGGCGGGGACGAGAAACACTG	0.493000												
PROM2	150696	broad.mit.edu	37	2	95954315	95954315	+	Missense_Mutation	SNP	C	C	T	rs35884217	byFrequency	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:95954315C>T	uc002suh.1	+	22	2552	c.2419C>T	c.(2419-2421)CGT>TGT	p.R807C	PROM2_uc002sui.2_Missense_Mutation_p.R807C|PROM2_uc002suj.2_Missense_Mutation_p.R461C|PROM2_uc002suk.2_Missense_Mutation_p.R807C|PROM2_uc002sul.2_Missense_Mutation_p.R333C|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	807	Cytoplasmic (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						CAAATACTTCCGTCCTATCCG	0.597000												
GPR45	11250	broad.mit.edu	37	2	105858611	105858611	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:105858611G>A	uc002tco.1	+	1	412	c.296G>A	c.(295-297)CGC>CAC	p.R99H		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	99	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						ATCACCGTGCGCTGGCACTTT	0.632000												
TGFBRAP1	9392	broad.mit.edu	37	2	105886050	105886050	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:105886050C>T	uc002tcq.2	-	11	2169	c.2085G>A	c.(2083-2085)GCG>GCA	p.A695A	TGFBRAP1_uc010fjc.2_Silent_p.A464A|TGFBRAP1_uc002tcr.3_Silent_p.A695A	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	695					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						AGTCCTCGGCCGCTGCAAAGT	0.652000												
C2orf40	84417	broad.mit.edu	37	2	106694342	106694342	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:106694342G>A	uc010fjf.2	+	4	515	c.407G>A	c.(406-408)GGC>GAC	p.G136D		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	136						extracellular region|transport vesicle					0						AGCCCCTACGGCTTTAGGCAT	0.458000												
TTL	150465	broad.mit.edu	37	2	113277874	113277874	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:113277874C>T	uc002thu.2	+	6	1070	c.891C>T	c.(889-891)AGC>AGT	p.S297S	TTL_uc010fkm.1_Intron	NM_153712	NP_714923	Q8NG68	TTL_HUMAN	tubulin tyrosine ligase	297	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0		Ovarian(717;0.024)		BRCA - Breast invasive adenocarcinoma(221;6.17e-07)|STAD - Stomach adenocarcinoma(1183;0.00644)		GCCTCCTGAGCGTGGAGCCTG	0.512000			T	ETV6	ALL							
YSK4	80122	broad.mit.edu	37	2	135738842	135738842	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:135738842G>A	uc002tue.1	-	9	3500	c.3469C>T	c.(3469-3471)CCA>TCA	p.P1157S	YSK4_uc002tuf.1_Missense_Mutation_p.P339S|YSK4_uc010fnc.1_Missense_Mutation_p.P291S|YSK4_uc010fnd.1_Missense_Mutation_p.P1044S|YSK4_uc010zbg.1_Missense_Mutation_p.P289S|YSK4_uc002tuh.3_Missense_Mutation_p.P885S|YSK4_uc002tui.3_3'UTR	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	1157	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCAGGCAATGGCCCAAAACGG	0.418000												
R3HDM1	23518	broad.mit.edu	37	2	136473119	136473119	+	Splice_Site	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:136473119G>T	uc002tuo.2	+	23	3002	c.2632_splice	c.e23-1	p.H878_splice	R3HDM1_uc010fni.2_Splice_Site_p.H877_splice|R3HDM1_uc002tup.2_Splice_Site_p.H823_splice|R3HDM1_uc010zbh.1_Splice_Site_p.H626_splice	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1								nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		TGTAATTGCAGCACAGCCCTC	0.443000												
HNMT	3176	broad.mit.edu	37	2	138771371	138771371	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:138771371A>G	uc002tvc.2	+	7	698	c.550A>G	c.(550-552)AAA>GAA	p.K184E	HNMT_uc002tvf.2_Missense_Mutation_p.K184E	NM_006895	NP_008826	P50135	HNMT_HUMAN	histamine N-methyltransferase isoform 1	184					respiratory gaseous exchange	cytoplasm	histamine N-methyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.125)	Amodiaquine(DB00613)|Histamine Phosphate(DB00667)|Quinacrine(DB01103)	CAAGCTGTGGAAAAAGTACGG	0.408000												
GALNT13	114805	broad.mit.edu	37	2	154996962	154996962	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:154996962T>C	uc002tyr.3	+	4	822	c.255T>C	c.(253-255)CTT>CTC	p.L85L	GALNT13_uc002tyt.3_Silent_p.L85L|GALNT13_uc010foc.1_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	85	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						AGTTTAACCTTATGGCCAGTG	0.358000												
LRP2	4036	broad.mit.edu	37	2	170101424	170101424	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:170101424G>A	uc002ues.2	-	22	3422	c.3209C>T	c.(3208-3210)TCG>TTG	p.S1070L	LRP2_uc010zdf.1_Missense_Mutation_p.S933L	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1070	LDL-receptor class A 9.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGTGAACGCCGAAGATGAACA	0.468000												
TTC30A	92104	broad.mit.edu	37	2	178483032	178483032	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:178483032C>T	uc002ulo.2	-	1	663	c.398G>A	c.(397-399)AGG>AAG	p.R133K		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	133					cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CACCAGGCTCCTGGACCCTGG	0.612000												
TTN	7273	broad.mit.edu	37	2	179423360	179423360	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:179423360T>G	uc010zfg.1	-	276	79346	c.79122A>C	c.(79120-79122)AAA>AAC	p.K26374N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K20069N|TTN_uc010zfi.1_Missense_Mutation_p.K20002N|TTN_uc010zfj.1_Missense_Mutation_p.K19877N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27301							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGGCTTGGTTTTTCTAAGA	0.358000												
TTN	7273	broad.mit.edu	37	2	179439680	179439680	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:179439680G>A	uc010zfg.1	-	275	63699	c.63475C>T	c.(63475-63477)CCA>TCA	p.P21159S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P14854S|TTN_uc010zfi.1_Missense_Mutation_p.P14787S|TTN_uc010zfj.1_Missense_Mutation_p.P14662S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22086							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTGGCCCTGGGATATCATGG	0.448000												
TTN	7273	broad.mit.edu	37	2	179447097	179447097	+	Missense_Mutation	SNP	C	C	T	rs72646868		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:179447097C>T	uc010zfg.1	-	263	58606	c.58382G>A	c.(58381-58383)CGT>CAT	p.R19461H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R13156H|TTN_uc010zfi.1_Missense_Mutation_p.R13089H|TTN_uc010zfj.1_Missense_Mutation_p.R12964H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20388							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCACAAATACGGAACTGATA	0.473000												
TTN	7273	broad.mit.edu	37	2	179499969	179499969	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:179499969T>C	uc010zfg.1	-	177	34467	c.34243A>G	c.(34243-34245)AGC>GGC	p.S11415G	TTN_uc010zfh.1_Missense_Mutation_p.S5110G|TTN_uc010zfi.1_Missense_Mutation_p.S5043G|TTN_uc010zfj.1_Missense_Mutation_p.S4918G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12342							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATCAAAGCTTGCACTTTCT	0.393000												
PLCL1	5334	broad.mit.edu	37	2	198950517	198950517	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:198950517C>T	uc010fsp.2	+	2	2567	c.2276C>T	c.(2275-2277)GCG>GTG	p.A759V	PLCL1_uc002uuv.3_Missense_Mutation_p.A680V	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	759	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GGAATTCCAGCGGATTGTTCG	0.418000												
ALS2	57679	broad.mit.edu	37	2	202587823	202587823	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:202587823G>A	uc002uyo.2	-	23	4001	c.3645C>T	c.(3643-3645)TCC>TCT	p.S1215S	ALS2_uc002uyp.3_Silent_p.S1215S|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	1215	MORN 7.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TATCATCTTCGGAAAGCAAAA	0.353000												
ABI2	10152	broad.mit.edu	37	2	204267383	204267383	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:204267383G>A	uc002vaa.2	+	9	1353	c.1118G>A	c.(1117-1119)CGC>CAC	p.R373H	ABI2_uc002uzz.2_Missense_Mutation_p.R306H|ABI2_uc010zih.1_Missense_Mutation_p.R21H|ABI2_uc010zii.1_Missense_Mutation_p.R367H|ABI2_uc010zij.1_Missense_Mutation_p.R250H|ABI2_uc002vab.2_Missense_Mutation_p.R261H|ABI2_uc010zik.1_Missense_Mutation_p.R98H|ABI2_uc010zil.1_Missense_Mutation_p.R208H|ABI2_uc010zim.1_Missense_Mutation_p.R159H|ABI2_uc002vac.2_Missense_Mutation_p.R159H|ABI2_uc010zin.1_Missense_Mutation_p.R21H	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	373	Pro-rich.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						CCCTATAGACGCCCTCCTTCC	0.443000												
FASTKD2	22868	broad.mit.edu	37	2	207651571	207651571	+	Silent	SNP	T	T	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:207651571T>A	uc002vbu.2	+	8	1952	c.1542T>A	c.(1540-1542)GCT>GCA	p.A514A	FASTKD2_uc002vbv.2_Silent_p.A514A|FASTKD2_uc002vbx.2_Silent_p.A514A|FASTKD2_uc002vbw.1_Silent_p.A514A	NM_001136193	NP_001129665	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	514					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|skin(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		TTCCCCTGGCTCCTTTTAATC	0.398000												
CPS1	1373	broad.mit.edu	37	2	211512675	211512675	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:211512675G>A	uc002vee.3	+	26	3362	c.3230G>A	c.(3229-3231)GGC>GAC	p.G1077D	CPS1_uc010fur.2_Missense_Mutation_p.G1083D|CPS1_uc010fus.2_Missense_Mutation_p.G626D	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1077					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AAGATCATGGGCACAAGCCCC	0.507000												
MREG	55686	broad.mit.edu	37	2	216809668	216809668	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:216809668C>T	uc002vfo.2	-	5	859	c.563G>A	c.(562-564)CGA>CAA	p.R188Q	MREG_uc002vfq.2_RNA	NM_018000	NP_060470	Q8N565	MREG_HUMAN	whn-dependent transcript 2	188						apical plasma membrane					0		Renal(323;0.0328)		Epithelial(149;4.64e-07)|all cancers(144;5.56e-05)|LUSC - Lung squamous cell carcinoma(224;0.00832)|Lung(261;0.0111)		GGGGTAAGTTCGACGAGCAAG	0.498000												
TMEM169	92691	broad.mit.edu	37	2	216964784	216964784	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:216964784C>A	uc010zjr.1	+	4	739	c.413C>A	c.(412-414)TCA>TAA	p.S138*	TMEM169_uc010zjs.1_Nonsense_Mutation_p.S138*|TMEM169_uc002vfw.2_Nonsense_Mutation_p.S138*|TMEM169_uc002vfv.3_Nonsense_Mutation_p.S138*	NM_001142310	NP_001135782	Q96HH4	TM169_HUMAN	transmembrane protein 169	138	Extracellular (Potential).					integral to membrane				ovary(1)	1		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTAAAGAGTCATCAAGGGAA	0.542000												
TNS1	7145	broad.mit.edu	37	2	218683363	218683363	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:218683363G>A	uc002vgt.2	-	24	3778	c.3380C>T	c.(3379-3381)GCC>GTC	p.A1127V	TNS1_uc002vgr.2_Missense_Mutation_p.A1114V|TNS1_uc002vgs.2_Missense_Mutation_p.A1106V|TNS1_uc010zjv.1_Missense_Mutation_p.A1106V	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1127	Ser-rich.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GTTTCTCTGGGCAGACGGGCT	0.632000												
TTLL4	9654	broad.mit.edu	37	2	219603187	219603187	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:219603187C>T	uc002viy.2	+	3	1158	c.788C>T	c.(787-789)CCG>CTG	p.P263L	TTLL4_uc010zkl.1_Missense_Mutation_p.P98L|TTLL4_uc010fvx.2_Missense_Mutation_p.P263L	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	263					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		GACTGTGCACCGCAGCCTGTT	0.572000												
TRIP12	9320	broad.mit.edu	37	2	230672480	230672480	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:230672480G>A	uc002vpw.1	-	16	2405	c.2296C>T	c.(2296-2298)CGT>TGT	p.R766C	TRIP12_uc002vpx.1_Missense_Mutation_p.R814C|TRIP12_uc002vpy.1_Missense_Mutation_p.R469C|TRIP12_uc010zlz.1_Intron|TRIP12_uc010fxh.1_Missense_Mutation_p.R772C	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	766	WWE.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CGATCATCACGCCACTGCCAT	0.433000												
ECEL1	9427	broad.mit.edu	37	2	233350780	233350780	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:233350780C>T	uc002vsv.2	-	2	789	c.584G>A	c.(583-585)CGA>CAA	p.R195Q	ECEL1_uc010fya.1_Missense_Mutation_p.R195Q|ECEL1_uc010fyb.1_5'UTR	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	195	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CGGGCCCAGTCGCTCGATCTC	0.602000												
CHRNG	1146	broad.mit.edu	37	2	233407735	233407735	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:233407735G>A	uc002vsx.1	+	7	769	c.748G>A	c.(748-750)GCC>ACC	p.A250T	CHRNG_uc010fye.1_Missense_Mutation_p.A198T	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	250	Helical; (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CAACATCATCGCCCCCTGTGT	0.607000												
GIGYF2	26058	broad.mit.edu	37	2	233652024	233652024	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:233652024C>T	uc002vti.3	+	11	1034	c.697C>T	c.(697-699)CGA>TGA	p.R233*	GIGYF2_uc010zmj.1_Nonsense_Mutation_p.R233*|GIGYF2_uc002vtg.2_Nonsense_Mutation_p.R233*|GIGYF2_uc002vtj.3_Nonsense_Mutation_p.R255*|GIGYF2_uc002vtk.3_Nonsense_Mutation_p.R233*|GIGYF2_uc002vth.3_Nonsense_Mutation_p.R233*|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Nonsense_Mutation_p.R64*	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	233	Arg-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		AGAGAGGTGGCGACCTCACAG	0.428000												
GPCPD1	56261	broad.mit.edu	37	20	5574004	5574004	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:5574004C>T	uc002wme.3	-	4	413	c.200G>A	c.(199-201)CGC>CAC	p.R67H		NM_019593	NP_062539	Q9NPB8	GPCP1_HUMAN	hypothetical protein LOC56261	67	CBM20.				glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0						TTTGAAGTAGCGATACTGAAC	0.353000												
KIF16B	55614	broad.mit.edu	37	20	16488691	16488691	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:16488691G>A	uc002wpg.1	-	7	769	c.611C>T	c.(610-612)GCG>GTG	p.A204V	KIF16B_uc010gch.1_Missense_Mutation_p.A204V|KIF16B_uc010gci.1_Missense_Mutation_p.A204V|KIF16B_uc010gcj.1_Missense_Mutation_p.A204V	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	204	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GATATTGCCCGCATCCATAAG	0.448000												
RRBP1	6238	broad.mit.edu	37	20	17599388	17599388	+	Translation_Start_Site	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:17599388G>A	uc010zrp.1	-	1	1075	c.-168C>T	c.(-170--166)CACGG>CATGG		RRBP1_uc002wpt.1_Intron|RRBP1_uc002wpu.2_Intron|RRBP1_uc002wpv.1_Intron|RRBP1_uc002wpw.1_Intron|RRBP1_uc010gcl.1_Intron			Q9P2E9	RRBP1_HUMAN	Homo sapiens mRNA for KIAA1398 protein, partial cds.						protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						ACCAGTCCCCGTGAGTTAGCG	0.527000												
DLGAP4	22839	broad.mit.edu	37	20	35060650	35060650	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:35060650G>A	uc002xff.2	+	3	965	c.530G>A	c.(529-531)GGC>GAC	p.G177D	DLGAP4_uc010zvp.1_Missense_Mutation_p.G177D	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	177					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				ATGGAGGACGGCAAGGGCCGG	0.642000												
TTPAL	79183	broad.mit.edu	37	20	43108886	43108886	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:43108886C>T	uc002xmc.1	+	3	371	c.247C>T	c.(247-249)CGC>TGC	p.R83C	TTPAL_uc002xmd.1_Missense_Mutation_p.R83C|TTPAL_uc010ggr.1_5'UTR	NM_024331	NP_077307	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	83						intracellular	transporter activity			breast(1)	1						CTTCCTGCTGCGCTTCCTCCG	0.567000												
ELMO2	63916	broad.mit.edu	37	20	45004410	45004410	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:45004410C>T	uc002xrt.1	-	12	1037	c.827G>A	c.(826-828)CGC>CAC	p.R276H	ELMO2_uc010zxq.1_Missense_Mutation_p.R8H|ELMO2_uc002xrs.1_Missense_Mutation_p.R23H|ELMO2_uc002xru.1_Missense_Mutation_p.R276H|ELMO2_uc010zxr.1_Missense_Mutation_p.R288H|ELMO2_uc010zxs.1_Missense_Mutation_p.R93H|ELMO2_uc002xrv.1_5'UTR|ELMO2_uc002xrw.2_Missense_Mutation_p.R93H|ELMO2_uc002xrx.1_Missense_Mutation_p.R276H	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	276					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TTTGATGGGGCGGTTCCCTCG	0.478000												
ARFGEF2	10564	broad.mit.edu	37	20	47639665	47639665	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:47639665T>C	uc002xtx.3	+	35	4854	c.4702T>C	c.(4702-4704)TTC>CTC	p.F1568L	ARFGEF2_uc010zyf.1_Missense_Mutation_p.F861L	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1568					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CAACATTGTGTTCTACCCTGC	0.478000												
TAF4	6874	broad.mit.edu	37	20	60578327	60578327	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:60578327G>T	uc002ybs.2	-	9	2375	c.2375C>A	c.(2374-2376)CCT>CAT	p.P792H		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	792					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TTTCACCACAGGGACTACAAA	0.493000												
SLC17A9	63910	broad.mit.edu	37	20	61598711	61598711	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:61598711C>T	uc002yea.3	+	13	1354	c.1170C>T	c.(1168-1170)GGC>GGT	p.G390G	SLC17A9_uc002ydz.3_Silent_p.G384G|SLC17A9_uc011aap.1_3'UTR	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	390					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						TGTGTCTAGGCGGCTACTTGA	0.637000												
KRTAP21-1	337977	broad.mit.edu	37	21	32127620	32127620	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:32127620C>G	uc011adi.1	-	1	77	c.77G>C	c.(76-78)TGT>TCT	p.C26S		NM_181619	NP_853650	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	26						intermediate filament				breast(1)	1						gccacagccacagccagagcc	0.109000												
C21orf45	54069	broad.mit.edu	37	21	33651281	33651281	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:33651281G>A	uc002ypi.2	-	1	96	c.45C>T	c.(43-45)GGC>GGT	p.G15G	C21orf45_uc011adn.1_Silent_p.G15G	NM_018944	NP_061817	Q9NYP9	MS18A_HUMAN	chromosome 21 open reading frame 45	15					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm					0						ACTCACAGCCGCCAGCGCATC	0.617000												
MRAP	56246	broad.mit.edu	37	21	33679016	33679016	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:33679016C>T	uc002ypj.2	+	4	359	c.172C>T	c.(172-174)CTC>TTC	p.L58F	MRAP_uc002ypk.2_Missense_Mutation_p.L58F|MRAP_uc011ado.1_5'UTR|MRAP_uc002ypl.2_Missense_Mutation_p.L58F|uc002ypm.2_RNA	NM_178817	NP_848932	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	58	Helical; (Potential).				positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding				0						CCTCATCTTGCTCTACATGTC	0.562000												
DOPEY2	9980	broad.mit.edu	37	21	37665815	37665815	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:37665815A>T	uc002yvg.2	+	37	6922	c.6843A>T	c.(6841-6843)TTA>TTT	p.L2281F	DOPEY2_uc011aeb.1_Missense_Mutation_p.L2230F	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2281					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CAAGGATCTTAAAACAACTGG	0.408000												
DYRK1A	1859	broad.mit.edu	37	21	38862544	38862544	+	Missense_Mutation	SNP	C	C	G	rs1049784		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:38862544C>G	uc002ywk.2	+	6	807	c.732C>G	c.(730-732)AAC>AAG	p.N244K	DYRK1A_uc002ywi.2_Missense_Mutation_p.N244K|DYRK1A_uc002ywj.2_Missense_Mutation_p.N235K|DYRK1A_uc002ywl.2_Missense_Mutation_p.N244K|DYRK1A_uc002ywm.2_Missense_Mutation_p.N244K|DYRK1A_uc011aei.1_Missense_Mutation_p.N5K	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	244	Protein kinase.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						TGTCCTACAACCTCTATGACT	0.393000												
UBASH3A	53347	broad.mit.edu	37	21	43833294	43833294	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:43833294C>T	uc002zbe.2	+	4	552	c.516C>T	c.(514-516)TTC>TTT	p.F172F	UBASH3A_uc002zbf.2_Silent_p.F172F|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Silent_p.F172F	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	172						cytosol|nucleus				ovary(3)	3						TCCGGGAATTCGCCATGACCT	0.622000												
RSPH1	89765	broad.mit.edu	37	21	43906511	43906511	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:43906511G>A	uc002zbg.2	-	4	440	c.335C>T	c.(334-336)ACC>ATC	p.T112I		NM_080860	NP_543136	Q8WYR4	RSPH1_HUMAN	testis-specific gene A2	112	MORN 4.				meiosis	cytosol|nucleus				ovary(1)	1						TCCAGTGTAGGTGTCATTATT	0.453000												
ITGB2	3689	broad.mit.edu	37	21	46308725	46308725	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:46308725T>G	uc002zgd.2	-	13	2007	c.1963A>C	c.(1963-1965)AAC>CAC	p.N655H	ITGB2_uc002zge.2_Missense_Mutation_p.N655H|ITGB2_uc002zgf.3_Missense_Mutation_p.N655H|ITGB2_uc011afl.1_Missense_Mutation_p.N577H|ITGB2_uc010gpw.2_Missense_Mutation_p.N598H|ITGB2_uc002zgg.2_Missense_Mutation_p.N655H	NM_001127491	NP_001120963	P05107	ITB2_HUMAN	integrin, beta 2 precursor	655	Extracellular (Potential).				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			ovary(4)|central_nervous_system(3)|breast(2)	9				Colorectal(79;0.0669)	Simvastatin(DB00641)	TTCACGGGGTTGTTCGACAGC	0.652000												
COL6A1	1291	broad.mit.edu	37	21	47423388	47423388	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr21:47423388C>T	uc002zhu.1	+	35	2650	c.2548C>T	c.(2548-2550)CGC>TGC	p.R850C	COL6A1_uc010gqd.1_Missense_Mutation_p.R181C|COL6A1_uc002zhv.1_Missense_Mutation_p.R181C|COL6A1_uc002zhw.1_5'UTR	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	850	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CACCACCAAGCGCTTCGCCAA	0.706000												
CHEK2	11200	broad.mit.edu	37	22	29121017	29121017	+	Silent	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr22:29121017G>T	uc003adu.1	-	4	612	c.540C>A	c.(538-540)CGC>CGA	p.R180R	CHEK2_uc003ads.1_Intron|CHEK2_uc010gvh.1_Intron|CHEK2_uc010gvi.1_Silent_p.R180R|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Silent_p.R223R|CHEK2_uc003adv.1_Silent_p.R180R|CHEK2_uc003adw.1_Silent_p.R180R|CHEK2_uc003adx.1_5'UTR|CHEK2_uc003ady.1_Silent_p.R180R|CHEK2_uc003adz.1_Intron	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	180			R -> C (in prostate cancer; somatic mutation).|R -> H (in prostate cancer; somatic mutation).		cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						TCAAAGGACGGCGTTTTCCTT	0.348000			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer			
ASCC2	84164	broad.mit.edu	37	22	30218382	30218382	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr22:30218382G>A	uc003agr.2	-	5	588	c.483C>T	c.(481-483)ATC>ATT	p.I161I	ASCC2_uc003ags.2_RNA|ASCC2_uc003agt.2_Silent_p.I161I|ASCC2_uc011akr.1_Silent_p.I85I	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			AGAGGTCCAGGATCTTTGGAA	0.473000												
MPST	4357	broad.mit.edu	37	22	37420785	37420785	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr22:37420785C>T	uc003aqj.2	+	3	941	c.529C>T	c.(529-531)CGC>TGC	p.R177C	MPST_uc003aqi.1_Missense_Mutation_p.R177C|MPST_uc003aqm.2_Missense_Mutation_p.R177C|MPST_uc011amu.1_Missense_Mutation_p.R197C|MPST_uc003aql.2_Missense_Mutation_p.R177C|MPST_uc003aqn.2_Missense_Mutation_p.R177C|MPST_uc003aqo.2_Missense_Mutation_p.R177C	NM_001130517	NP_001123989	P25325	THTM_HUMAN	mercaptopyruvate sulfurtransferase isoform 2	177	Rhodanese 2.				cyanate catabolic process|response to toxin		3-mercaptopyruvate sulfurtransferase activity|thiosulfate sulfurtransferase activity				0						GGAATCCCGGCGCTTCCAGGT	0.682000												
MKL1	57591	broad.mit.edu	37	22	40807837	40807837	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr22:40807837A>G	uc003ayv.1	-	12	2560	c.2353T>C	c.(2353-2355)TCC>CCC	p.S785P	MKL1_uc003ayw.1_Missense_Mutation_p.S785P|MKL1_uc010gye.1_Missense_Mutation_p.V788A|MKL1_uc010gyf.1_Missense_Mutation_p.S735P	NM_020831	NP_065882	Q969V6	MKL1_HUMAN	megakaryoblastic leukemia 1 protein	785	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GCCAGGGGGGACCCACAGACT	0.597000			T	RBM15	acute megakaryocytic leukemia							
RANGAP1	5905	broad.mit.edu	37	22	41676938	41676938	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr22:41676938A>G	uc003azs.2	-	1	1581	c.111T>C	c.(109-111)GAT>GAC	p.D37D	RANGAP1_uc003azt.2_Silent_p.D37D|RANGAP1_uc003azu.2_Silent_p.D37D|RANGAP1_uc011aoz.1_5'Flank	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	37					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						GAAACTCACCATCTTCTGCAG	0.413000												
PARVB	29780	broad.mit.edu	37	22	44514998	44514998	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr22:44514998C>T	uc003ben.2	+	4	406	c.354C>T	c.(352-354)GGC>GGT	p.G118G	PARVB_uc003bem.2_Silent_p.G151G|PARVB_uc010gzn.2_Silent_p.G66G|PARVB_uc003beo.2_Silent_p.G81G	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	118	CH 1.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				TGTATGACGGCCAGGTGCTGC	0.597000												
PLXNB2	23654	broad.mit.edu	37	22	50726198	50726198	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr22:50726198C>T	uc003bkv.3	-	7	1612	c.1506G>A	c.(1504-1506)CCG>CCA	p.P502P		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	502	Extracellular (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTCGGCCCGCGGACACTCGG	0.716000												
LMF2	91289	broad.mit.edu	37	22	50944598	50944598	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr22:50944598C>T	uc003blp.2	-	5	671	c.640G>A	c.(640-642)GCC>ACC	p.A214T	LMF2_uc010hba.2_Missense_Mutation_p.A36T|LMF2_uc003blo.2_Missense_Mutation_p.A189T|NCAPH2_uc003blq.3_5'Flank|NCAPH2_uc003blv.2_5'Flank|NCAPH2_uc003blr.3_5'Flank|NCAPH2_uc010hbb.2_5'Flank|NCAPH2_uc003blu.3_5'Flank|NCAPH2_uc003bls.3_5'Flank|NCAPH2_uc003blt.3_5'Flank|NCAPH2_uc003blw.3_5'Flank|NCAPH2_uc003blx.3_5'Flank|NCAPH2_uc003bly.3_5'Flank	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	214						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCGAACCAGGCGGCGGGCGTG	0.672000												
CAMK1	8536	broad.mit.edu	37	3	9802450	9802450	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:9802450A>G	uc003bst.2	-	8	813	c.635T>C	c.(634-636)CTC>CCC	p.L212P	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_RNA|CAMK1_uc003bss.2_5'Flank|uc003bsv.1_RNA	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	212	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		GTAACCGCAGAGCCTGGGCAG	0.557000												
CAND2	23066	broad.mit.edu	37	3	12858445	12858445	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:12858445A>G	uc003bxk.2	+	10	2063	c.2014A>G	c.(2014-2016)ACA>GCA	p.T672A	CAND2_uc003bxj.2_Missense_Mutation_p.T579A	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	672	HEAT 14.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						GCGACTGGCCACACTGGCAGC	0.662000												
NUP210	23225	broad.mit.edu	37	3	13372104	13372104	+	Silent	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:13372104G>T	uc003bxv.1	-	30	4049	c.3966C>A	c.(3964-3966)GTC>GTA	p.V1322V		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1322	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GTCCATCCAGGACGCGGTAGC	0.512000												
C3orf20	84077	broad.mit.edu	37	3	14744719	14744719	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:14744719C>T	uc003byy.2	+	6	1232	c.828C>T	c.(826-828)AGC>AGT	p.S276S	C3orf20_uc003byz.2_Silent_p.S154S|C3orf20_uc003bza.2_Silent_p.S154S|C3orf20_uc003byx.1_Silent_p.S276S	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	276						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						TGGAGTTCAGCGACCCCTGCC	0.597000												
GALNTL2	117248	broad.mit.edu	37	3	16237382	16237382	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:16237382C>T	uc003car.3	+	2	1130	c.655C>T	c.(655-657)CCC>TCC	p.P219S	GALNTL2_uc003caq.3_5'UTR	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	219	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						CGACACAGTGCCCAGGGCCTT	0.617000												
KAT2B	8850	broad.mit.edu	37	3	20113953	20113953	+	Splice_Site	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:20113953T>C	uc003cbq.2	+	2	876	c.430_splice	c.e2+2	p.A144_splice		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B						cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ATGCCCTAGGTGAGTTCCTAA	0.458000												
GPD1L	23171	broad.mit.edu	37	3	32181857	32181857	+	Silent	SNP	C	C	T	rs139369157	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:32181857C>T	uc003cew.2	+	4	564	c.504C>T	c.(502-504)ATC>ATT	p.I168I		NM_015141	NP_055956	Q8N335	GPD1L_HUMAN	glycerol-3-phosphate dehydrogenase 1-like	168					glycerol-3-phosphate catabolic process	glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|NAD binding|protein homodimerization activity				0						AGACCACCATCGGTAAGCACT	0.473000												
XIRP1	165904	broad.mit.edu	37	3	39227701	39227701	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:39227701C>T	uc003cjk.1	-	2	3457	c.3236G>A	c.(3235-3237)GGC>GAC	p.G1079D	XIRP1_uc003cji.2_Missense_Mutation_p.G1079D|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1079							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGGGGTGGGGCCCTGCTTGTG	0.627000												
RPL14	9045	broad.mit.edu	37	3	40499484	40499484	+	Splice_Site	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:40499484T>C	uc003ckg.2	+	2	156	c.105_splice	c.e2+2	p.R35_splice	RPL14_uc003ckh.2_Splice_Site_p.R35_splice|RPL14_uc003cki.2_Splice_Site	NM_003973	NP_003964	P50914	RL14_HUMAN	ribosomal protein L14						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CAGAACAGGGTAAGTGTCACA	0.483000												
EXOSC7	23016	broad.mit.edu	37	3	45038710	45038710	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:45038710G>A	uc003coi.2	+	4	415	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	EXOSC7_uc003coh.1_Missense_Mutation_p.R64Q|EXOSC7_uc011bae.1_Missense_Mutation_p.R129Q|EXOSC7_uc010his.1_Missense_Mutation_p.R48Q|EXOSC7_uc003coj.2_Missense_Mutation_p.R129Q	NM_015004	NP_055819	Q15024	EXOS7_HUMAN	exosome component 7	129					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00911)|KIRC - Kidney renal clear cell carcinoma(197;0.0509)|Kidney(197;0.064)		ATTAGTCCTCGGGAGCACTGC	0.473000												
CCR2	729230	broad.mit.edu	37	3	46399668	46399668	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:46399668T>A	uc003cpn.3	+	2	1135	c.650T>A	c.(649-651)ATC>AAC	p.I217N	CCR2_uc003cpm.3_Missense_Mutation_p.I217N	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	217	Helical; Name=5; (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		CCGCTGCTCATCATGGTCATC	0.468000												
COL7A1	1294	broad.mit.edu	37	3	48602300	48602300	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:48602300A>G	uc003ctz.2	-	117	8735	c.8734T>C	c.(8734-8736)TGT>CGT	p.C2912R	UCN2_uc003cty.1_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2912	Nonhelical region (NC2).|BPTI/Kunitz inhibitor.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTCCCTCCACAGCCACCATAG	0.657000												
RHOA	387	broad.mit.edu	37	3	49412922	49412922	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:49412922T>C	uc003cwu.2	-	2	377	c.101A>G	c.(100-102)TAT>TGT	p.Y34C	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	34	Effector region (Potential).			Y->F: Abolishes AMPylation by Haemophilus IbpA.|Y->A: Abolishes interaction with DGKQ.	axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	TGTGGGCACATACACCTCTGG	0.463000												
CDHR4	389118	broad.mit.edu	37	3	49836453	49836453	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:49836453T>C	uc010hkz.2	-	3	386	c.377A>G	c.(376-378)CAG>CGG	p.Q126R	CDHR4_uc003cxp.2_Missense_Mutation_p.Q126R|CDHR4_uc011bcw.1_Missense_Mutation_p.Q126R	NM_001007540	NP_001007541	A6H8M9	CDHR4_HUMAN	cadherin-like 29 precursor	126	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						ACCAGCACACTGGATATGGCT	0.602000												
DOCK3	1795	broad.mit.edu	37	3	51196730	51196730	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:51196730G>A	uc011bds.1	+	11	907	c.884G>A	c.(883-885)CGA>CAA	p.R295Q		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	295						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CATGTGATCCGAATAGGTACT	0.388000												
TMEM110	375346	broad.mit.edu	37	3	52883877	52883877	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:52883877C>T	uc003dge.2	-	4	439	c.358G>A	c.(358-360)GTG>ATG	p.V120M	TMEM110_uc003dgc.3_Missense_Mutation_p.V120M	NM_198563	NP_940965	Q86TL2	TM110_HUMAN	transmembrane protein 110	120	Helical; (Potential).					integral to membrane				large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		CGCACCCCCACGTAGATGAGC	0.622000												
CACNA1D	776	broad.mit.edu	37	3	53700399	53700399	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:53700399C>T	uc003dgv.3	+	7	1116	c.953C>T	c.(952-954)GCG>GTG	p.A318V	CACNA1D_uc003dgu.3_Missense_Mutation_p.A318V|CACNA1D_uc003dgy.3_Missense_Mutation_p.A318V|CACNA1D_uc003dgw.3_5'UTR	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	318	Extracellular (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GCTCCATGTGCGTTCTCAGGG	0.537000												
ERC2	26059	broad.mit.edu	37	3	56044541	56044541	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:56044541C>T	uc003dhr.1	-	9	2112	c.1856G>A	c.(1855-1857)CGA>CAA	p.R619Q	ERC2_uc003dht.1_Missense_Mutation_p.R90Q	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	619	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTTCTCTTTTCGGAAGGATTC	0.393000												
ATXN7	6314	broad.mit.edu	37	3	63965643	63965643	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:63965643A>G	uc003dlw.3	+	6	1105	c.552A>G	c.(550-552)TCA>TCG	p.S184S	ATXN7_uc003dlv.2_Silent_p.S184S|ATXN7_uc010hnv.2_Silent_p.S184S|ATXN7_uc010hnw.2_Silent_p.S39S|ATXN7_uc011bfn.1_Silent_p.S39S	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	184	Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		CTCCCACTTCAGTATTTTCCT	0.458000												
PDZRN3	23024	broad.mit.edu	37	3	73433966	73433966	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:73433966G>T	uc003dpl.1	-	10	1847	c.1751C>A	c.(1750-1752)TCG>TAG	p.S584*	PDZRN3_uc011bgh.1_Nonsense_Mutation_p.S241*|PDZRN3_uc010hoe.1_Nonsense_Mutation_p.S282*|PDZRN3_uc011bgf.1_Nonsense_Mutation_p.S301*|PDZRN3_uc011bgg.1_Nonsense_Mutation_p.S304*	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	584							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CTCTTGCTCCGAGCTCTCGTC	0.642000												
CNTN3	5067	broad.mit.edu	37	3	74474047	74474047	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:74474047G>A	uc003dpm.1	-	4	483	c.403C>T	c.(403-405)CGT>TGT	p.R135C		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	135	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TGGCCTTCACGCACAGACACT	0.398000												
ROBO1	6091	broad.mit.edu	37	3	78649287	78649287	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:78649287T>C	uc003dqe.2	-	30	5125	c.4917A>G	c.(4915-4917)GGA>GGG	p.G1639G	ROBO1_uc003dqb.2_Silent_p.G1600G|ROBO1_uc003dqc.2_Silent_p.G1539G|ROBO1_uc003dqd.2_Silent_p.G1594G|ROBO1_uc010hoh.2_Silent_p.G831G	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1639	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TATTATCTTCTCCTCTTTCAT	0.363000												
EPHA6	285220	broad.mit.edu	37	3	96962894	96962894	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:96962894C>G	uc010how.1	+	5	1412	c.1369C>G	c.(1369-1371)CTC>GTC	p.L457V	EPHA6_uc003drp.1_Missense_Mutation_p.L457V	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	362	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GAGAAAAGATCTCACATACAG	0.478000												
OR5AC2	81050	broad.mit.edu	37	3	97806749	97806749	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:97806749G>A	uc011bgs.1	+	1	733	c.733G>A	c.(733-735)GCC>ACC	p.A245T		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CACATGCGGCGCCCATCTGCT	0.423000												
HHLA2	11148	broad.mit.edu	37	3	108072517	108072517	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:108072517A>G	uc003dwy.3	+	4	475	c.308A>G	c.(307-309)AAT>AGT	p.N103S	HHLA2_uc011bhl.1_Intron|HHLA2_uc010hpu.2_Missense_Mutation_p.N103S|HHLA2_uc003dwz.2_Missense_Mutation_p.N103S	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	103	Ig-like V-type 1.					integral to membrane				ovary(1)	1						CAAAATGGGAATGCGTCGCTA	0.403000												
KIAA1524	57650	broad.mit.edu	37	3	108298166	108298166	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:108298166A>T	uc003dxb.3	-	7	1049	c.780T>A	c.(778-780)GAT>GAA	p.D260E	KIAA1524_uc003dxc.1_Missense_Mutation_p.D101E|KIAA1524_uc010hpw.1_Missense_Mutation_p.D101E	NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	260						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TCTTAAGGAGATCCATCAGTA	0.323000												
CCDC80	151887	broad.mit.edu	37	3	112324517	112324517	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:112324517A>C	uc003dzf.2	-	8	2818	c.2600T>G	c.(2599-2601)CTT>CGT	p.L867R	CCDC80_uc011bhv.1_Missense_Mutation_p.L840R|CCDC80_uc003dzg.2_Missense_Mutation_p.L867R	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	867										ovary(2)	2						TCCGACTAGAAGCATGGAGAA	0.448000												
SIDT1	54847	broad.mit.edu	37	3	113320434	113320434	+	Splice_Site	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:113320434G>T	uc003eak.2	+	11	1697	c.1046_splice	c.e11-1	p.G349_splice	SIDT1_uc011bif.1_Splice_Site|SIDT1_uc003eaj.1_Splice_Site_p.G349_splice|SIDT1_uc011big.1_Splice_Site_p.G102_splice|SIDT1_uc011bih.1_5'Flank	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor							integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						TTTTTTAACAGGCTCTGGAAA	0.413000												
SLC12A8	84561	broad.mit.edu	37	3	124829094	124829094	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:124829094C>T	uc003ehv.3	-	9	1109	c.998G>A	c.(997-999)CGC>CAC	p.R333H	SLC12A8_uc003ehw.3_Missense_Mutation_p.R362H|SLC12A8_uc003eht.3_Missense_Mutation_p.R134H|SLC12A8_uc003ehu.3_Missense_Mutation_p.R86H|SLC12A8_uc010hry.2_Missense_Mutation_p.R86H	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	333					potassium ion transport	integral to membrane	symporter activity				0						CTGCAGGATGCGGGGAGCTCC	0.507000												
TF	7018	broad.mit.edu	37	3	133486949	133486949	+	Silent	SNP	C	C	T	rs34657694		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:133486949C>T	uc003epu.1	+	18	3291	c.1563C>T	c.(1561-1563)GGC>GGT	p.G521G	TF_uc011blt.1_Silent_p.G394G|TF_uc003epw.1_Intron|TF_uc003epv.1_Silent_p.G521G	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	521	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	TGGGCTCAGGCCTAAACCTGT	0.448000												
CHST2	9435	broad.mit.edu	37	3	142840554	142840554	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:142840554G>A	uc003evm.2	+	2	1785	c.896G>A	c.(895-897)CGC>CAC	p.R299H		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	299	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						CGCAAGTACCGCACACTAGTC	0.647000												
WWTR1	25937	broad.mit.edu	37	3	149290705	149290705	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:149290705C>T	uc003exe.2	-	2	530	c.514G>A	c.(514-516)GTC>ATC	p.V172I	WWTR1_uc003exf.2_Missense_Mutation_p.V172I|WWTR1_uc011bns.1_Missense_Mutation_p.V172I|WWTR1_uc003exh.2_Missense_Mutation_p.V172I	NM_015472	NP_056287	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	172					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GTGGAACTGACGGCAGGGTGG	0.413000												
FAM194A	131831	broad.mit.edu	37	3	150403619	150403619	+	Silent	SNP	G	G	A	rs149996868		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:150403619G>A	uc003eyg.2	-	6	750	c.693C>T	c.(691-693)TTC>TTT	p.F231F	FAM194A_uc003eyh.2_Silent_p.F85F	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	231										skin(2)|ovary(1)	3						GAGAAGGCTCGAACAGTGTTA	0.383000												
PLCH1	23007	broad.mit.edu	37	3	155199080	155199080	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:155199080G>A	uc011bok.1	-	23	5036	c.4759C>T	c.(4759-4761)CGC>TGC	p.R1587C	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.R1549C	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1587					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GCAATATTGCGCACTCTGCTC	0.512000												
PLCH1	23007	broad.mit.edu	37	3	155203278	155203278	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:155203278G>A	uc011bok.1	-	22	3142	c.2865C>T	c.(2863-2865)GGC>GGT	p.G955G	PLCH1_uc011boj.1_Silent_p.G955G|PLCH1_uc011bol.1_Silent_p.G917G	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	955					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCTCAGCACGCCATCTTGAT	0.522000												
TNFSF10	8743	broad.mit.edu	37	3	172241098	172241098	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:172241098A>C	uc003fid.2	-	1	172	c.77T>G	c.(76-78)CTG>CGG	p.L26R	TNFSF10_uc003fie.2_Missense_Mutation_p.L26R|TNFSF10_uc010hwu.1_RNA	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	26	Helical; Signal-anchor for type II membrane protein; (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			GAGAGACTGCAGGAGCACTGT	0.547000												
PIK3CA	5290	broad.mit.edu	37	3	178936092	178936092	+	Missense_Mutation	SNP	A	A	G	rs121913274		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:178936092A>G	uc003fjk.2	+	10	1791	c.1634A>G	c.(1633-1635)GAG>GGG	p.E545G		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAATCACTGAGCAGGAGAAA	0.353000	E545G(KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545A(AGS_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)		
USP13	8975	broad.mit.edu	37	3	179478997	179478997	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:179478997C>T	uc003fkh.2	+	17	2127	c.2046C>T	c.(2044-2046)GGC>GGT	p.G682G		NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	682	UBA 1.				ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			GAAATATGGGCGCCGAGGTGG	0.522000												
EIF4G1	1981	broad.mit.edu	37	3	184038434	184038434	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:184038434C>T	uc003fnp.2	+	8	752	c.554C>T	c.(553-555)CCA>CTA	p.P185L	EIF4G1_uc003fno.1_Missense_Mutation_p.P126L|EIF4G1_uc010hxw.1_Missense_Mutation_p.P21L|EIF4G1_uc003fnt.2_5'UTR|EIF4G1_uc003fnq.2_Missense_Mutation_p.P98L|EIF4G1_uc003fnr.2_Missense_Mutation_p.P21L|EIF4G1_uc010hxx.2_Missense_Mutation_p.P192L|EIF4G1_uc003fns.2_Missense_Mutation_p.P145L|EIF4G1_uc010hxy.2_Missense_Mutation_p.P192L|EIF4G1_uc010hxz.1_Missense_Mutation_p.P98L|EIF4G1_uc003fnv.3_Missense_Mutation_p.P185L|EIF4G1_uc003fnu.3_Missense_Mutation_p.P185L|EIF4G1_uc003fnw.2_Missense_Mutation_p.P192L|EIF4G1_uc003fnx.2_5'UTR|EIF4G1_uc003fny.3_5'UTR	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	185	PABPC1-binding.			DPNQ->AAAA: Loss of PABPC1 binding; when associated with 174-AAAAA-178.	insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATTCGAGATCCAAACCAAGGA	0.537000												
EIF4G1	1981	broad.mit.edu	37	3	184044360	184044360	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:184044360C>T	uc003fnp.2	+	22	3466	c.3268C>T	c.(3268-3270)CGA>TGA	p.R1090*	EIF4G1_uc003fnt.2_Nonsense_Mutation_p.R801*|EIF4G1_uc003fnq.2_Nonsense_Mutation_p.R1003*|EIF4G1_uc003fnr.2_Nonsense_Mutation_p.R926*|EIF4G1_uc010hxx.2_Nonsense_Mutation_p.R1097*|EIF4G1_uc003fns.2_Nonsense_Mutation_p.R1050*|EIF4G1_uc010hxy.2_Nonsense_Mutation_p.R1097*|EIF4G1_uc003fnv.3_Nonsense_Mutation_p.R1091*|EIF4G1_uc003fnu.3_Nonsense_Mutation_p.R1090*|EIF4G1_uc003fnw.2_Nonsense_Mutation_p.R1097*|EIF4G1_uc003fnx.2_Nonsense_Mutation_p.R895*|EIF4G1_uc003fny.3_Nonsense_Mutation_p.R894*|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1090					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACCTGGAGGGCGACTGAGCTG	0.597000												
EPHB3	2049	broad.mit.edu	37	3	184297328	184297328	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:184297328G>A	uc003foz.2	+	10	2302	c.1865G>A	c.(1864-1866)CGG>CAG	p.R622Q		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	622	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GAGGCTGTTCGGGAGTTTGCC	0.552000												
TP63	8626	broad.mit.edu	37	3	189604248	189604248	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:189604248T>C	uc003fry.2	+	11	1504	c.1415T>C	c.(1414-1416)ATG>ACG	p.M472T	TP63_uc003frz.2_Missense_Mutation_p.M472T|TP63_uc010hzc.1_Missense_Mutation_p.M472T|TP63_uc003fsc.2_Missense_Mutation_p.M378T|TP63_uc003fsd.2_Missense_Mutation_p.M378T|TP63_uc010hzd.1_Missense_Mutation_p.M293T	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	472					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ATGAACAGCATGAACAAGCTG	0.488000									Hay-Wells_syndrome	HNSCC(45;0.13)		
LRRC15	131578	broad.mit.edu	37	3	194081221	194081221	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:194081221G>A	uc003ftu.2	-	2	638	c.552C>T	c.(550-552)AGC>AGT	p.S184S	LRRC15_uc003ftt.2_Silent_p.S190S	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	184	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TGTGGGTGAGGCTATTCTTGC	0.572000												
MUC4	4585	broad.mit.edu	37	3	195480005	195480005	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:195480005T>C	uc011bto.1	-	21	15501	c.15041A>G	c.(15040-15042)CAG>CGG	p.Q5014R	MUC4_uc010hzq.2_5'UTR|MUC4_uc003fuz.2_Missense_Mutation_p.Q740R|MUC4_uc003fva.2_Missense_Mutation_p.Q622R|MUC4_uc003fvb.2_Missense_Mutation_p.Q658R|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Missense_Mutation_p.Q658R|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Missense_Mutation_p.Q622R|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Missense_Mutation_p.Q706R|MUC4_uc011bti.1_Missense_Mutation_p.Q706R|MUC4_uc011btj.1_Missense_Mutation_p.Q883R|MUC4_uc011btk.1_Missense_Mutation_p.Q622R|MUC4_uc011btl.1_Missense_Mutation_p.Q651R|MUC4_uc011btm.1_Missense_Mutation_p.Q831R|MUC4_uc011btn.1_Missense_Mutation_p.Q622R|MUC4_uc003fvo.2_Missense_Mutation_p.Q906R|MUC4_uc003fvp.2_Missense_Mutation_p.Q855R	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1899	EGF-like 1.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCACATGGGCTGACAGCCCAG	0.582000												
KIAA1530	57654	broad.mit.edu	37	4	1343557	1343557	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:1343557G>A	uc003gde.3	+	3	791	c.344G>A	c.(343-345)CGG>CAG	p.R115Q		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	115											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			GCGACCACCCGGGCCGTGGAA	0.622000												
JAKMIP1	152789	broad.mit.edu	37	4	6080672	6080672	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:6080672C>T	uc003giu.3	-	8	1572	c.1296G>A	c.(1294-1296)CCG>CCA	p.P432P	JAKMIP1_uc010idb.1_Silent_p.P432P|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Silent_p.P432P|JAKMIP1_uc011bwc.1_Silent_p.P267P|JAKMIP1_uc003giv.3_Silent_p.P432P|JAKMIP1_uc010ide.2_Silent_p.P432P	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	432	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCACCTTGGGCGGTTTCAGAC	0.577000												
CPZ	8532	broad.mit.edu	37	4	8613861	8613861	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:8613861C>T	uc003glm.2	+	8	1461	c.1335C>T	c.(1333-1335)AAC>AAT	p.N445N	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Silent_p.N308N|CPZ_uc003glo.2_Silent_p.N434N|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	445					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCATCATCAACGGGGCGGACT	0.413000												
SEL1L3	23231	broad.mit.edu	37	4	25849011	25849011	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:25849011C>T	uc003gru.3	-	2	790	c.638G>A	c.(637-639)CGC>CAC	p.R213H		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	213						integral to membrane	binding				0						TTTGAAAGGGCGTTCAAAAGG	0.458000												
GRXCR1	389207	broad.mit.edu	37	4	42965093	42965093	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:42965093G>A	uc003gwt.2	+	2	569	c.569G>A	c.(568-570)CGA>CAA	p.R190Q		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	190	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						GAACGATGCCGACGAGTTTCT	0.428000												
ATP10D	57205	broad.mit.edu	37	4	47593216	47593216	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:47593216T>A	uc003gxk.1	+	23	4263	c.4099T>A	c.(4099-4101)TCA>ACA	p.S1367T	ATP10D_uc003gxl.1_Missense_Mutation_p.S615T	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1367	Cytoplasmic (Potential).|ATP (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TGCTAACCAATCAGCTGGCAA	0.463000												
FRYL	285527	broad.mit.edu	37	4	48545898	48545898	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:48545898G>C	uc003gyh.1	-	44	6123	c.5518C>G	c.(5518-5520)CTC>GTC	p.L1840V	FRYL_uc003gyg.1_Missense_Mutation_p.L536V|FRYL_uc003gyi.1_Missense_Mutation_p.L728V|FRYL_uc003gyj.1_Missense_Mutation_p.L135V	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1840					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GTTGCAGTGAGAGGCTGCTTT	0.443000												
SRD5A3	79644	broad.mit.edu	37	4	56233814	56233814	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:56233814A>G	uc003hau.2	+	4	717	c.622A>G	c.(622-624)ATG>GTG	p.M208V	uc003hav.1_Intron|uc003haw.1_Intron	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	208	Helical; (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			TCTTGGGATGATGATGTTCAT	0.408000												
LPHN3	23284	broad.mit.edu	37	4	62845287	62845287	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:62845287G>T	uc010ihh.2	+	15	2781	c.2608G>T	c.(2608-2610)GAT>TAT	p.D870Y	LPHN3_uc003hcq.3_Missense_Mutation_p.D870Y|LPHN3_uc003hct.2_Missense_Mutation_p.D263Y	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	857	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CCAGCACAGTGATGCGGTCCA	0.418000												
BMP2K	55589	broad.mit.edu	37	4	79832739	79832739	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:79832739G>A	uc003hlk.2	+	16	3204	c.3038G>A	c.(3037-3039)CGC>CAC	p.R1013H	PAQR3_uc003hlm.2_Intron|PAQR3_uc003hln.2_Intron|uc010ijm.1_5'Flank	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	1013						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						CCTACCTATCGCACTCCAGAG	0.488000												
AFF1	4299	broad.mit.edu	37	4	88035905	88035905	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:88035905C>T	uc003hqj.3	+	11	2306	c.1899C>T	c.(1897-1899)GGC>GGT	p.G633G	AFF1_uc011ccz.1_Silent_p.G640G|AFF1_uc003hqk.3_Silent_p.G633G|AFF1_uc011cda.1_Silent_p.G271G	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	633						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TTCCCTATGGCTCCCGAGACC	0.612000												
DSPP	1834	broad.mit.edu	37	4	88535421	88535421	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:88535421A>G	uc003hqu.2	+	5	1727	c.1607A>G	c.(1606-1608)GAC>GGC	p.D536G		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	536	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		GGGAATGATGACAATGACAAA	0.264000												
NDST3	9348	broad.mit.edu	37	4	119176867	119176867	+	Nonstop_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:119176867G>T	uc003ibx.2	+	14	3025	c.2622G>T	c.(2620-2622)TAG>TAT	p.*874Y		NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	874						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						AAGTAAGATAGCACTGAGAGA	0.458000												
KIAA1109	84162	broad.mit.edu	37	4	123229133	123229133	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:123229133G>A	uc003ieh.2	+	56	9916	c.9871G>A	c.(9871-9873)GCC>ACC	p.A3291T	KIAA1109_uc003iel.1_Missense_Mutation_p.A1226T	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3291					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTATAAGGCCGCCTATGACAA	0.353000												
FAT4	79633	broad.mit.edu	37	4	126389938	126389938	+	Silent	SNP	A	A	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:126389938A>T	uc003ifj.3	+	11	12171	c.12171A>T	c.(12169-12171)GGA>GGT	p.G4057G	FAT4_uc011cgp.1_Silent_p.G2320G|FAT4_uc003ifi.1_Silent_p.G1535G	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4057	Laminin G-like 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGTCAGATGGACATTTTCACA	0.368000												
POU4F2	5458	broad.mit.edu	37	4	147561536	147561536	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:147561536G>A	uc003ikv.2	+	2	1054	c.806G>A	c.(805-807)CGC>CAC	p.R269H		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	269	POU-specific.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					AAGCAGCGACGCATCAAGCTG	0.687000												
SFRP2	6423	broad.mit.edu	37	4	154709838	154709838	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:154709838G>A	uc003inv.1	-	1	391	c.150C>T	c.(148-150)TGC>TGT	p.C50C		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	50	FZ.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)				CGATGCCGTGGCACAGCTGCA	0.647000												
DDX60	55601	broad.mit.edu	37	4	169227857	169227857	+	Silent	SNP	C	C	T	rs140161501		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:169227857C>T	uc003irp.2	-	5	571	c.279G>A	c.(277-279)GCG>GCA	p.A93A		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	93							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AGTTGAAATACGCATACTCGG	0.363000												
C4orf41	60684	broad.mit.edu	37	4	184622881	184622881	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:184622881A>G	uc003ivx.2	+	26	3059	c.2883A>G	c.(2881-2883)GAA>GAG	p.E961E	C4orf41_uc003ivw.2_Silent_p.E961E|C4orf41_uc010isc.2_Silent_p.E305E|C4orf41_uc003ivy.2_Silent_p.E567E	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	961											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		GTGCTAGTGAATGCTTTTGTC	0.378000												
LPCAT1	79888	broad.mit.edu	37	5	1489881	1489881	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:1489881A>G	uc003jcm.2	-	4	703	c.586T>C	c.(586-588)TCC>CCC	p.S196P		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	196	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TTTCCGTTGGACTGCGCCCGT	0.502000												
CDH18	1016	broad.mit.edu	37	5	19571802	19571802	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:19571802G>C	uc003jgc.2	-	7	1516	c.1139C>G	c.(1138-1140)CCA>CGA	p.P380R	CDH18_uc003jgd.2_Missense_Mutation_p.P380R|CDH18_uc011cnm.1_Missense_Mutation_p.P380R	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	380	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AAATAGTGGTGGTTCATCTAC	0.423000												
RXFP3	51289	broad.mit.edu	37	5	33938026	33938026	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:33938026G>A	uc003jic.1	+	1	1538	c.1181G>A	c.(1180-1182)CGC>CAC	p.R394H		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	394	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						CTCGTGCGCCGCGAGTTCCGC	0.632000												
UGT3A2	167127	broad.mit.edu	37	5	36049272	36049272	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:36049272G>A	uc003jjz.1	-	4	655	c.562C>T	c.(562-564)CGT>TGT	p.R188C	UGT3A2_uc011cos.1_Missense_Mutation_p.R154C|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	188	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGCAAGGAACGGAATACTGGA	0.463000												
NIPBL	25836	broad.mit.edu	37	5	37006531	37006531	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:37006531G>A	uc003jkl.3	+	17	4427	c.3928G>A	c.(3928-3930)GCT>ACT	p.A1310T	NIPBL_uc003jkk.3_Missense_Mutation_p.A1310T	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1310					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			ATCAGCGGATGCTTGTCTTAC	0.343000												
NUP155	9631	broad.mit.edu	37	5	37314427	37314427	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:37314427G>T	uc003jku.1	-	22	2427	c.2309C>A	c.(2308-2310)GCT>GAT	p.A770D	NUP155_uc003jkt.1_Missense_Mutation_p.A711D|NUP155_uc010iuz.1_Missense_Mutation_p.A770D	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	770					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACTTAGTTGAGCCTCTAATGA	0.308000												
RGNEF	64283	broad.mit.edu	37	5	73205302	73205302	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:73205302C>T	uc011csq.1	+	33	4238	c.4227C>T	c.(4225-4227)GGC>GGT	p.G1409G	RGNEF_uc003kcx.2_Silent_p.G1409G|RGNEF_uc010izf.2_Silent_p.G1409G|RGNEF_uc011csr.1_Silent_p.G1096G|RGNEF_uc003kcz.3_Silent_p.G373G|RGNEF_uc003kda.3_Silent_p.G329G	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1409					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		AGCAGGAGGGCCTGTCTCTCG	0.602000												
F2RL2	2151	broad.mit.edu	37	5	75914009	75914009	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:75914009C>T	uc003kem.2	-	2	708	c.523G>A	c.(523-525)GGC>AGC	p.G175S	IQGAP2_uc003kek.2_Intron|IQGAP2_uc010izv.2_Intron|IQGAP2_uc011csv.1_Intron|IQGAP2_uc003kel.2_Intron|F2RL2_uc011csw.1_Missense_Mutation_p.G153S	NM_004101	NP_004092	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	175	Helical; Name=3; (Potential).				platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			skin(2)|ovary(1)	3		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		TACATGTTGCCATAGAAGATG	0.512000												
VCAN	1462	broad.mit.edu	37	5	82837780	82837780	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:82837780C>T	uc003kii.3	+	8	9314	c.8958C>T	c.(8956-8958)GTC>GTT	p.V2986V	VCAN_uc003kij.3_Silent_p.V1999V|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.V1650V	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2986	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCTATGGGGTCGAGGCAGGTG	0.488000												
GPR98	84059	broad.mit.edu	37	5	90074728	90074728	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:90074728G>A	uc003kju.2	+	64	12992	c.12896G>A	c.(12895-12897)CGA>CAA	p.R4299Q	GPR98_uc003kjt.2_Missense_Mutation_p.R2005Q|GPR98_uc003kjw.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4299	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGCCATGTGCGACTCTGGTAC	0.453000												
NR2F1	7025	broad.mit.edu	37	5	92921019	92921019	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:92921019A>G	uc003kkj.2	+	1	1977	c.290A>G	c.(289-291)CAC>CGC	p.H97R		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	97	NR C4-type.|Nuclear receptor.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		AGCGGCAAGCACTACGGCCAA	0.632000												
LNPEP	4012	broad.mit.edu	37	5	96341852	96341852	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:96341852G>A	uc003kmv.1	+	10	2375	c.1861G>A	c.(1861-1863)GTT>ATT	p.V621I	LNPEP_uc003kmw.1_Missense_Mutation_p.V607I	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	621	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		TTTAGTGACTGTTCAAAAGAA	0.328000												
AQPEP	206338	broad.mit.edu	37	5	115339034	115339034	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:115339034T>C	uc003kro.2	+	12	2158	c.1994T>C	c.(1993-1995)TTA>TCA	p.L665S	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	665	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TATGATAAATTAGGTTGGAAG	0.289000												
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139905707	139905707	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:139905707G>A	uc003lfs.1	+	26	4743	c.4619G>A	c.(4618-4620)AGC>AAC	p.S1540N	ANKHD1_uc003lfr.2_Missense_Mutation_p.S1540N|ANKHD1_uc003lfu.1_Missense_Mutation_p.S1020N|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S279N|ANKHD1_uc003lfw.2_Missense_Mutation_p.S178N|ANKHD1_uc010jfl.2_5'UTR|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1540						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACTCCCAGCACCAATCGG	0.413000												
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139909045	139909045	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:139909045G>T	uc003lfs.1	+	29	6638	c.6514G>T	c.(6514-6516)GGC>TGC	p.G2172C	ANKHD1_uc003lfr.2_Missense_Mutation_p.G2172C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.G911C|ANKHD1_uc003lfw.2_Missense_Mutation_p.G810C|ANKHD1_uc010jfl.2_Missense_Mutation_p.G607C|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.G309C	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2172						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCACCTCAAGGCCCACCAGC	0.443000												
IK	3550	broad.mit.edu	37	5	140039372	140039372	+	Silent	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:140039372C>A	uc003lgq.2	+	14	1337	c.1227C>A	c.(1225-1227)TCC>TCA	p.S409S		NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	409					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATCAAGTCCATCAATGAAA	0.468000												
PCDHB6	56130	broad.mit.edu	37	5	140531705	140531705	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:140531705C>T	uc003lir.2	+	1	1867	c.1867C>T	c.(1867-1869)CGC>TGC	p.R623C	PCDHB6_uc011dah.1_Missense_Mutation_p.R487C	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	623	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGCGAGGTGCGCACCGCCAG	0.687000												
FBXO38	81545	broad.mit.edu	37	5	147803681	147803681	+	Splice_Site	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:147803681G>A	uc003lpf.1	+	13	1858	c.1738_splice	c.e13+1	p.G580_splice	FBXO38_uc003lpg.1_Splice_Site_p.G580_splice|FBXO38_uc003lph.2_Splice_Site_p.G580_splice	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b							cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACAAGCAGGTAATCATGTG	0.448000												
FABP6	2172	broad.mit.edu	37	5	159659135	159659135	+	Missense_Mutation	SNP	G	G	A	rs17856662		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:159659135G>A	uc003lya.1	+	2	226	c.98G>A	c.(97-99)CGC>CAC	p.R33H	FABP6_uc003lxx.1_Missense_Mutation_p.R82H|FABP6_uc003lxz.1_Missense_Mutation_p.R82H	NM_001445	NP_001436	P51161	FABP6_HUMAN	gastrotropin isoform 2	33					bile acid and bile salt transport|bile acid metabolic process|negative regulation of cell proliferation	cytosol	transporter activity				0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAAAAGGCCCGCAACTTCAAG	0.537000												
GABRA6	2559	broad.mit.edu	37	5	161128599	161128599	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:161128599G>A	uc003lyu.2	+	9	1520	c.1182G>A	c.(1180-1182)GCG>GCA	p.A394A	GABRA6_uc003lyv.2_Silent_p.A165A	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	394	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCACGAGAGCGCCCATCTTAC	0.473000										TCGA Ovarian(5;0.080)		
DOCK2	1794	broad.mit.edu	37	5	169174437	169174437	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:169174437T>A	uc003maf.2	+	23	2385	c.2305T>A	c.(2305-2307)TCC>ACC	p.S769T	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.S261T	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	769					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTTTGAAGAATCCATGAGACG	0.358000												
UIMC1	51720	broad.mit.edu	37	5	176333041	176333041	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:176333041G>A	uc011dfp.1	-	14	2087	c.1920C>T	c.(1918-1920)GAC>GAT	p.D640D	UIMC1_uc003mfc.1_Silent_p.D517D|UIMC1_uc003mfd.1_Silent_p.D270D	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	640					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGACTTGATGTCTGCATCTG	0.418000												
F13A1	2162	broad.mit.edu	37	6	6266932	6266932	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:6266932G>A	uc003mwv.2	-	4	553	c.430C>T	c.(430-432)CGG>TGG	p.R144W	F13A1_uc011dib.1_Missense_Mutation_p.R81W	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	144					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	ATGGACAGCCGCACAGACCTG	0.512000												
HIVEP1	3096	broad.mit.edu	37	6	12122709	12122709	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:12122709G>A	uc003nac.2	+	4	2860	c.2681G>A	c.(2680-2682)CGT>CAT	p.R894H	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	894					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GGGCATCCCCGTACACTTGTG	0.478000												
GFOD1	54438	broad.mit.edu	37	6	13486905	13486905	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:13486905G>A	uc003nat.1	-	1	883	c.218C>T	c.(217-219)CCG>CTG	p.P73L	GFOD1_uc003nas.1_5'Flank|C6orf114_uc003nav.2_5'Flank	NM_018988	NP_061861	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain	73						extracellular region	binding|oxidoreductase activity			ovary(2)	2	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			GGTGAGGGGCGGCGGCAGGTT	0.592000												
TRIM26	7726	broad.mit.edu	37	6	30166571	30166571	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:30166571G>A	uc003npr.2	-	3	519	c.310C>T	c.(310-312)CGA>TGA	p.R104*	TRIM26_uc003nps.2_Nonsense_Mutation_p.R104*|TRIM26_uc010jry.2_5'UTR|TRIM26_uc003npt.2_Nonsense_Mutation_p.R104*|TRIM26_uc003npu.1_Nonsense_Mutation_p.R104*	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	104	B box-type.						DNA binding|zinc ion binding			ovary(2)|lung(1)	3						TCTCGGTGTCGCTCGCACAAC	0.642000												
MDC1	9656	broad.mit.edu	37	6	30670948	30670948	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:30670948C>T	uc003nrg.3	-	12	6238	c.5798G>A	c.(5797-5799)CGG>CAG	p.R1933Q	MDC1_uc003nrf.3_Missense_Mutation_p.R564Q	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1933	BRCT 1.|Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CTTGACTGTCCGGCGGATGCG	0.627000								Other_conserved_DNA_damage_response_genes				
HLA-DRA	3122	broad.mit.edu	37	6	32410444	32410444	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:32410444G>A	uc003obh.2	+	2	383	c.302G>A	c.(301-303)CGC>CAC	p.R101H	HLA-DRA_uc003obi.2_Missense_Mutation_p.R101H	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	101	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						ATGACAAAGCGCTCCAACTAT	0.483000									T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Kaposi_Sarcoma_Familial_Clustering_of			
HLA-DPB1	3115	broad.mit.edu	37	6	33052994	33052994	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:33052994T>C	uc003ocu.1	+	3	691	c.632T>C	c.(631-633)GTC>GCC	p.V211A	HLA-DPB1_uc011dqo.1_RNA|HLA-DPB1_uc011dqp.1_Missense_Mutation_p.V210A|HLA-DPB1_uc011dqq.1_Missense_Mutation_p.V107A	NM_002121	NP_002112	P04440	DPB1_HUMAN	major histocompatibility complex, class II, DP	211	Beta-2.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex				ovary(1)	1						GATAGTCCTGTCACCGTGGAG	0.567000												
ZBTB22	9278	broad.mit.edu	37	6	33283621	33283621	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:33283621A>G	uc003oeb.2	-	2	1225	c.1073T>C	c.(1072-1074)ATA>ACA	p.I358T	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.I358T	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GACATCACTTATGCTGAGGGT	0.567000												
SYNGAP1	8831	broad.mit.edu	37	6	33411173	33411173	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:33411173C>T	uc011dri.1	+	15	3039	c.2844C>T	c.(2842-2844)GGC>GGT	p.G948G	SYNGAP1_uc010juy.2_Silent_p.G919G|SYNGAP1_uc010juz.2_Silent_p.G660G	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	948					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						ATGGAGGGGGCGGTGGCCATG	0.557000												
ITPR3	3710	broad.mit.edu	37	6	33631536	33631536	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:33631536C>T	uc011drk.1	+	11	1246	c.1027C>T	c.(1027-1029)CGC>TGC	p.R343C		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	343	MIR 4.|Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CCGCACAGGCCGCAGGAATGC	0.592000												
PPARD	5467	broad.mit.edu	37	6	35392202	35392202	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:35392202A>G	uc003okm.2	+	7	1033	c.724A>G	c.(724-726)AGC>GGC	p.S242G	PPARD_uc003okl.2_Missense_Mutation_p.S242G|PPARD_uc003okn.2_Missense_Mutation_p.S242G|PPARD_uc011dtb.1_Missense_Mutation_p.S203G|PPARD_uc011dtc.1_Missense_Mutation_p.S144G	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	242					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	CAAGGAGATCAGCGTGCACGT	0.587000												
FGD2	221472	broad.mit.edu	37	6	36982747	36982747	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:36982747T>A	uc010jwp.1	+	8	1133	c.962T>A	c.(961-963)CTC>CAC	p.L321H	FGD2_uc003ong.2_Missense_Mutation_p.L43H|FGD2_uc011dtv.1_5'UTR|FGD2_uc003oni.1_Missense_Mutation_p.L127H	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	321	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						AACACCCTGCTCCGTGAGGGC	0.632000												
TRERF1	55809	broad.mit.edu	37	6	42204045	42204045	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:42204045C>A	uc003osd.2	-	16	3527	c.2964G>T	c.(2962-2964)GAG>GAT	p.E988D	TRERF1_uc011duq.1_Missense_Mutation_p.E905D|TRERF1_uc003osb.2_Missense_Mutation_p.E744D|TRERF1_uc003osc.2_Missense_Mutation_p.E744D|TRERF1_uc003ose.2_Missense_Mutation_p.E1008D	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	988	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CGGGTGGTGGCTCCGGGGACT	0.547000												
KLHDC3	116138	broad.mit.edu	37	6	42985306	42985306	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:42985306G>A	uc003otl.2	+	3	373	c.204G>A	c.(202-204)GGG>GGA	p.G68G	KLHDC3_uc003otm.2_RNA|KLHDC3_uc010jyf.2_Silent_p.G68G|KLHDC3_uc003otn.2_5'UTR|KLHDC3_uc003oto.2_Intron	NM_057161	NP_476502	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	68	Kelch 1.				reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			upper_aerodigestive_tract(1)	1			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCATCCGTGGGCAAGCTCCTG	0.622000												
CLIC5	53405	broad.mit.edu	37	6	45917038	45917038	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:45917038A>G	uc003oxv.3	-	3	837	c.731T>C	c.(730-732)GTC>GCC	p.V244A	CLIC5_uc003oxu.3_Missense_Mutation_p.V85A|CLIC5_uc003oxx.2_Missense_Mutation_p.V85A	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5 isoform a	244					female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			ovary(1)|skin(1)	2						GATCTTATTGACGTCTGTCTT	0.537000												
GPR116	221395	broad.mit.edu	37	6	46828548	46828548	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:46828548A>G	uc003oyo.3	-	16	2572	c.2283T>C	c.(2281-2283)CAT>CAC	p.H761H	GPR116_uc011dwj.1_Silent_p.H316H|GPR116_uc011dwk.1_Silent_p.H190H|GPR116_uc003oyp.3_Silent_p.H619H|GPR116_uc003oyq.3_Silent_p.H761H|GPR116_uc010jzi.1_Silent_p.H433H	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	761	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			AGCTGATTTCATGTTCCGCTT	0.438000												
GPR110	266977	broad.mit.edu	37	6	46977701	46977701	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:46977701A>C	uc003oyt.2	-	11	1669	c.1470T>G	c.(1468-1470)ATT>ATG	p.I490M	GPR110_uc011dwl.1_Missense_Mutation_p.I178M	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	490	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						AAACGGGTAGAATGTTCCCCA	0.418000												
TINAG	27283	broad.mit.edu	37	6	54212228	54212228	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:54212228A>G	uc003pcj.2	+	6	958	c.812A>G	c.(811-813)CAG>CGG	p.Q271R	TINAG_uc010jzt.2_Intron	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	271					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			CTATCCCCTCAGAATTTGATC	0.433000												
DST	667	broad.mit.edu	37	6	56328469	56328469	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:56328469C>A	uc003pdf.2	-	94	16452	c.16424G>T	c.(16423-16425)AGA>ATA	p.R5475I	DST_uc003pcz.3_Missense_Mutation_p.R5297I|DST_uc011dxj.1_Missense_Mutation_p.R5326I|DST_uc011dxk.1_Missense_Mutation_p.R5337I|DST_uc003pcy.3_Missense_Mutation_p.R4971I|DST_uc003pcv.3_Missense_Mutation_p.R93I|DST_uc003pcw.3_Missense_Mutation_p.R54I|DST_uc003pcx.3_Missense_Mutation_p.R54I	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7407					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGGCCGGGATCTTCGGCCTCG	0.592000												
IBTK	25998	broad.mit.edu	37	6	82936995	82936995	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:82936995C>T	uc003pjl.1	-	5	1095	c.568G>A	c.(568-570)GTG>ATG	p.V190M	IBTK_uc011dyv.1_Missense_Mutation_p.V190M|IBTK_uc011dyw.1_Missense_Mutation_p.V190M|IBTK_uc010kbi.1_Translation_Start_Site|IBTK_uc003pjm.2_Missense_Mutation_p.V190M	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	190	RCC1 1.				negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		GACAGAAACACGGAGTGAAAT	0.363000												
ZNF292	23036	broad.mit.edu	37	6	87953265	87953265	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:87953265G>A	uc003plm.3	+	6	855	c.814G>A	c.(814-816)GCT>ACT	p.A272T		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TGAAAAAAGCGCTCTTGTTTT	0.353000												
FUT9	10690	broad.mit.edu	37	6	96651800	96651800	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:96651800C>A	uc003pop.3	+	3	1110	c.769C>A	c.(769-771)CTA>ATA	p.L257I		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	257	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CACGGAAAAGCTATACAATGC	0.343000												
PRDM13	59336	broad.mit.edu	37	6	100062155	100062155	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:100062155G>A	uc003pqg.1	+	4	1905	c.1644G>A	c.(1642-1644)CCG>CCA	p.P548P		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		CGTTGCCACcggccgtcgcgg	0.468000												
RNF217	154214	broad.mit.edu	37	6	125366443	125366443	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:125366443G>A	uc003pzs.2	+	4	431	c.93G>A	c.(91-93)ACG>ACA	p.T31T	RNF217_uc003pzr.2_Silent_p.T88T|RNF217_uc003pzt.2_RNA	NM_152553	NP_689766	Q8TC41	RN217_HUMAN	ring finger protein 217	31					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0162)		ATAACTTAACGCATGAAGACT	0.418000												
KIAA1244	57221	broad.mit.edu	37	6	138618006	138618006	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:138618006G>A	uc003qhu.2	+	21	3562	c.3562G>A	c.(3562-3564)GCC>ACC	p.A1188T		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1188					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CCTGGGGAATGCCATGCTGAG	0.562000												
HECA	51696	broad.mit.edu	37	6	139487653	139487653	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:139487653C>T	uc003qin.2	+	2	789	c.504C>T	c.(502-504)GGC>GGT	p.G168G		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	168					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		CAAAGAAGGGCTACGACCTGG	0.587000												
HECA	51696	broad.mit.edu	37	6	139487805	139487805	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:139487805C>A	uc003qin.2	+	2	941	c.656C>A	c.(655-657)GCG>GAG	p.A219E		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	219					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		GGTGAGGCGGCGGAGGAGGCA	0.592000												
UTRN	7402	broad.mit.edu	37	6	144812155	144812155	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:144812155G>A	uc003qkt.2	+	31	4446	c.4354G>A	c.(4354-4356)GAT>AAT	p.D1452N		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1452	Spectrin 10.|Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GCGTGTGCTGGATGGCGTGAA	0.527000												
SNX9	51429	broad.mit.edu	37	6	158349643	158349643	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:158349643C>T	uc003qqv.1	+	12	1370	c.1197C>T	c.(1195-1197)TGC>TGT	p.C399C		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	399	BAR.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		AGCAGAAGTGCGAGGCTGTGG	0.587000												
SLC22A1	6580	broad.mit.edu	37	6	160543054	160543054	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:160543054G>A	uc003qtc.2	+	1	192	c.87G>A	c.(85-87)TCG>TCA	p.S29S	SLC22A1_uc003qtd.2_Silent_p.S29S	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	29	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		GCCTGCTGTCGGCTGCCTTTG	0.597000												
RPS6KA2	6196	broad.mit.edu	37	6	166844007	166844007	+	Silent	SNP	C	C	T	rs140163975		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:166844007C>T	uc003qvb.1	-	16	1734	c.1515G>A	c.(1513-1515)TCG>TCA	p.S505S	RPS6KA2_uc011ego.1_Silent_p.S416S|RPS6KA2_uc010kkl.1_Silent_p.S416S|RPS6KA2_uc003qvc.1_Silent_p.S513S|RPS6KA2_uc003qvd.1_Silent_p.S530S	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	505	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		CTTCGCGCTCCGAGAAGTATC	0.602000												
MLLT4	4301	broad.mit.edu	37	6	168281130	168281130	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:168281130C>A	uc003qwd.2	+	6	969	c.827C>A	c.(826-828)GCT>GAT	p.A276D	MLLT4_uc003qwb.1_Missense_Mutation_p.A276D|MLLT4_uc003qwc.1_Missense_Mutation_p.A277D|MLLT4_uc003qwf.2_Translation_Start_Site	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	277	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GCAGACTTTGCTGTGGCTGAA	0.393000			T	MLL	AL							
PAPOLB	56903	broad.mit.edu	37	7	4900547	4900547	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:4900547G>A	uc003snk.2	-	1	1079	c.895C>T	c.(895-897)CCT>TCT	p.P299S	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	298					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		TCCCATACAGGCAAATTAAGA	0.443000												
RNF216	54476	broad.mit.edu	37	7	5752387	5752387	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:5752387G>A	uc003soy.1	-	12	1960	c.1770C>T	c.(1768-1770)GCC>GCT	p.A590A	RNF216_uc010ksz.1_Silent_p.A212A|RNF216_uc010kta.1_Silent_p.A212A|RNF216_uc011jwj.1_Silent_p.A212A|RNF216_uc003sox.1_Silent_p.A647A	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	590	IBR-type.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CCTCCTCCTCGGCTTTTCGCT	0.562000												
AIMP2	7965	broad.mit.edu	37	7	6057478	6057478	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:6057478G>A	uc003spo.2	+	3	489	c.376G>A	c.(376-378)GCA>ACA	p.A126T		NM_006303	NP_006294	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting	126	Interaction with PARK2.				apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			ovary(1)	1						CGTGATCAACGCAAACCCGGC	0.532000												
MACC1	346389	broad.mit.edu	37	7	20201455	20201455	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:20201455A>G	uc003sus.3	-	4	340	c.31T>C	c.(31-33)TCA>CCA	p.S11P	MACC1_uc010kug.2_Missense_Mutation_p.S11P	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	11					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						ATTCTTCCTGACCGAAAATGT	0.323000												
COL1A2	1278	broad.mit.edu	37	7	94056959	94056959	+	Silent	SNP	C	C	T	rs149097024		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:94056959C>T	uc003ung.1	+	49	3759	c.3288C>T	c.(3286-3288)GGC>GGT	p.G1096G	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1096			Missing (in OI4).|G -> A (in OI3).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GTCCCCCTGGCCCTCCTGGAC	0.532000										HNSCC(75;0.22)		
PTCD1	26024	broad.mit.edu	37	7	99017660	99017660	+	Missense_Mutation	SNP	C	C	T	rs150466149		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:99017660C>T	uc003uqh.2	-	8	2164	c.2033G>A	c.(2032-2034)CGG>CAG	p.R678Q	PTCD1_uc011kiw.1_Missense_Mutation_p.R727Q	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	678										ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GGGCTTGGTCCGGAACTTCTG	0.612000												
MUC17	140453	broad.mit.edu	37	7	100682329	100682329	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:100682329T>C	uc003uxp.1	+	3	7685	c.7632T>C	c.(7630-7632)AGT>AGC	p.S2544S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2544	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|41.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTCCAACAGTCCTGTGGTCA	0.473000												
DNAJC2	27000	broad.mit.edu	37	7	102953432	102953432	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:102953432G>A	uc003vbo.2	-	16	2004	c.1753C>T	c.(1753-1755)CCT>TCT	p.P585S	PMPCB_uc003vbl.2_3'UTR|PMPCB_uc003vbm.2_3'UTR|PMPCB_uc010liv.2_3'UTR|PMPCB_uc010liw.2_3'UTR|PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_Missense_Mutation_p.P210S|DNAJC2_uc010lix.2_Missense_Mutation_p.P532S|DNAJC2_uc003vbp.2_Missense_Mutation_p.P210S	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	585	SANT 2.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1						GTCCTGCCAGGCACCGCTTCT	0.408000												
LAMB1	3912	broad.mit.edu	37	7	107577640	107577640	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:107577640C>T	uc003vew.2	-	26	4179	c.3844G>A	c.(3844-3846)GCC>ACC	p.A1282T	LAMB1_uc003vev.2_Missense_Mutation_p.A1306T	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1282	Potential.|Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTTCTTTGGCTGTGCTGTTG	0.378000												
TMEM168	64418	broad.mit.edu	37	7	112423832	112423832	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:112423832C>T	uc003vgn.2	-	2	1441	c.1049G>A	c.(1048-1050)CGC>CAC	p.R350H	TMEM168_uc010lju.2_Missense_Mutation_p.R350H|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	350						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						GCAAAAATGGCGCATCCCTTT	0.408000												
SPAM1	6677	broad.mit.edu	37	7	123593630	123593630	+	Silent	SNP	A	A	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:123593630A>T	uc003vld.2	+	4	408	c.6A>T	c.(4-6)GGA>GGT	p.G2G	SPAM1_uc003vle.2_Silent_p.G2G|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Silent_p.G2G|SPAM1_uc010lku.2_Silent_p.G2G	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	2					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	TTACAATGGGAGTGCTAAAAT	0.363000												
PLXNA4	91584	broad.mit.edu	37	7	131866253	131866253	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:131866253A>G	uc003vra.3	-	18	3608	c.3379T>C	c.(3379-3381)TCC>CCC	p.S1127P		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1127	Extracellular (Potential).|IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ATGAGCAGGGACTGGACGTTG	0.602000												
BPGM	669	broad.mit.edu	37	7	134346677	134346677	+	Missense_Mutation	SNP	C	C	T	rs141221644	by1000genomes	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:134346677C>T	uc003vrv.2	+	3	959	c.418C>T	c.(418-420)CGG>TGG	p.R140W	BPGM_uc003vrw.2_Missense_Mutation_p.R140W|BPGM_uc003vrx.2_Missense_Mutation_p.R140W	NM_199186	NP_954655	P07738	PMGE_HUMAN	bisphosphoglycerate mutase	140					glycolysis|respiratory gaseous exchange		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CTACAACGACCGGAGGTATAA	0.473000												
CNOT4	4850	broad.mit.edu	37	7	135079001	135079001	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:135079001C>T	uc003vsv.1	-	10	1603	c.1296G>A	c.(1294-1296)TCG>TCA	p.S432S	CNOT4_uc003vss.2_Silent_p.S429S|CNOT4_uc011kpz.1_Silent_p.S429S|CNOT4_uc003vst.2_Silent_p.S432S|CNOT4_uc003vsu.1_Silent_p.S429S|CNOT4_uc011kpy.1_Silent_p.S432S	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	432					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						GAGATGTGGGCGAAAGGGAAG	0.498000												
SVOPL	136306	broad.mit.edu	37	7	138312915	138312915	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:138312915C>T	uc011kqh.1	-	10	1057	c.1057G>A	c.(1057-1059)GGT>AGT	p.G353S	SVOPL_uc003vue.2_Missense_Mutation_p.G201S	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	353	Helical; (Potential).					integral to membrane	transmembrane transporter activity				0						GCAATTTCACCGATGGTGCTG	0.552000												
ATP6V0A4	50617	broad.mit.edu	37	7	138437555	138437555	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:138437555G>A	uc003vuf.2	-	10	1082	c.844C>T	c.(844-846)CAG>TAG	p.Q282*	ATP6V0A4_uc003vug.2_Nonsense_Mutation_p.Q282*|ATP6V0A4_uc003vuh.2_Nonsense_Mutation_p.Q282*	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	282	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						AGCAGGCGCTGGCGGTGAGAC	0.488000												
TTC26	79989	broad.mit.edu	37	7	138833067	138833067	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:138833067G>A	uc003vus.2	+	7	775	c.661G>A	c.(661-663)GCA>ACA	p.A221T	TTC26_uc003vuq.2_Missense_Mutation_p.A221T|TTC26_uc011kqm.1_Intron|TTC26_uc003vur.3_Missense_Mutation_p.A221T|TTC26_uc011kqn.1_Missense_Mutation_p.A221T|TTC26_uc011kqo.1_Missense_Mutation_p.A190T|TTC26_uc011kqp.1_Missense_Mutation_p.A116T|TTC26_uc003vut.2_Missense_Mutation_p.A81T|TTC26_uc011kqq.1_Intron	NM_024926	NP_079202	A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26 isoform 1	221							binding			ovary(1)	1						TAGTACCATCGCACTCAATCT	0.388000												
EPHB6	2051	broad.mit.edu	37	7	142566336	142566336	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:142566336G>A	uc011kst.1	+	15	2912	c.2125G>A	c.(2125-2127)GCC>ACC	p.A709T	EPHB6_uc011ksu.1_Missense_Mutation_p.A709T|EPHB6_uc003wbs.2_Missense_Mutation_p.A417T|EPHB6_uc003wbt.2_Missense_Mutation_p.A183T|EPHB6_uc003wbu.2_Missense_Mutation_p.A417T|EPHB6_uc003wbv.2_Missense_Mutation_p.A93T	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	709	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GGCCGGGGGCGCCGAAAGCCT	0.677000												
ZNF425	155054	broad.mit.edu	37	7	148802270	148802270	+	Silent	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:148802270G>T	uc003wfj.2	-	4	766	c.693C>A	c.(691-693)TCC>TCA	p.S231S		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	231					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GCCTGAGTTCGGACTTCCCTC	0.532000												
KRBA1	84626	broad.mit.edu	37	7	149416733	149416733	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:149416733C>T	uc003wfz.2	+	2	403	c.4C>T	c.(4-6)CGG>TGG	p.R2W	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_5'Flank	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	2										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGACGTGATGCGGGAGAACTA	0.652000												
ZNF862	643641	broad.mit.edu	37	7	149547305	149547305	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:149547305C>T	uc010lpn.2	+	5	1187	c.995C>T	c.(994-996)CCG>CTG	p.P332L	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						GAGGAGCTGCCGGTGGTGTTC	0.607000												
RNF32	140545	broad.mit.edu	37	7	156468498	156468498	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:156468498T>C	uc003wmo.2	+	8	975	c.793T>C	c.(793-795)TTG>CTG	p.L265L	RNF32_uc010lqm.2_Silent_p.L265L|RNF32_uc003wmq.2_Silent_p.L265L|RNF32_uc003wmr.2_Silent_p.L265L|RNF32_uc003wmu.2_RNA	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	265						aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		TCTTCAGCAGTTGGAAGAAAA	0.483000												
ESYT2	57488	broad.mit.edu	37	7	158560362	158560362	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:158560362G>A	uc003wob.1	-	8	1117	c.1051C>T	c.(1051-1053)CGG>TGG	p.R351W	ESYT2_uc003woc.1_Missense_Mutation_p.R175W|ESYT2_uc003wod.1_Missense_Mutation_p.R351W	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	379	C2 1.					integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						ACAGGAAACCGCAACTGAGCT	0.448000												
MYOM2	9172	broad.mit.edu	37	8	2092718	2092718	+	Missense_Mutation	SNP	C	C	T	rs147501499	byFrequency	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:2092718C>T	uc003wpx.3	+	37	4349	c.4211C>T	c.(4210-4212)ACC>ATC	p.T1404I	MYOM2_uc011kwi.1_Missense_Mutation_p.T829I	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1404	Ig-like C2-type 5.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GTCAGCATGACCATCAAAGGC	0.532000												
CSMD1	64478	broad.mit.edu	37	8	3087599	3087599	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:3087599G>A	uc011kwk.1	-	27	4701	c.4311C>T	c.(4309-4311)AAC>AAT	p.N1437N	CSMD1_uc011kwj.1_Silent_p.N829N|CSMD1_uc003wqe.2_Silent_p.N593N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1437	Extracellular (Potential).|Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAAAGAACCGGTTATTCAGCT	0.463000												
TUSC3	7991	broad.mit.edu	37	8	15519705	15519705	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:15519705C>A	uc003wwt.2	+	5	818	c.608C>A	c.(607-609)GCT>GAT	p.A203D	TUSC3_uc003wwr.2_Missense_Mutation_p.A203D|TUSC3_uc003wws.2_Missense_Mutation_p.A203D|TUSC3_uc003wwu.2_Missense_Mutation_p.A203D|TUSC3_uc003wwv.2_Missense_Mutation_p.A203D|TUSC3_uc003www.2_Missense_Mutation_p.A203D|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.A203D	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	203	Helical; (Potential).				cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		GGTACCATTGCTTTGGCCCTG	0.383000												
ATP6V1B2	526	broad.mit.edu	37	8	20075767	20075767	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:20075767A>C	uc003wzp.2	+	13	1584	c.1370A>C	c.(1369-1371)AAG>ACG	p.K457T	ATP6V1B2_uc003wzq.1_5'Flank	NM_001693	NP_001684	P21281	VATB2_HUMAN	vacuolar H+ATPase B2	457					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TTTCTGCAGAAGTTTGAGAGG	0.413000												
DOK2	9046	broad.mit.edu	37	8	21767139	21767139	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:21767139G>T	uc003wzy.1	-	5	1015	c.922C>A	c.(922-924)CGT>AGT	p.R308S	DOK2_uc003wzx.1_Missense_Mutation_p.R308S|DOK2_uc003wzz.1_Missense_Mutation_p.R154S|DOK2_uc010lth.1_Missense_Mutation_p.R154S	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	308					blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		CCCAAGGAACGGGCCACCGCA	0.667000												
LOXL2	4017	broad.mit.edu	37	8	23167240	23167240	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:23167240G>A	uc003xdh.1	-	10	2160	c.1821C>T	c.(1819-1821)GGC>GGT	p.G607G	LOXL2_uc010lty.1_Silent_p.G146G	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	607	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		AGTCGGACTGGCCATTGTTGT	0.682000												
DPYSL2	1808	broad.mit.edu	37	8	26492331	26492331	+	Silent	SNP	C	C	T	rs35621323	byFrequency	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:26492331C>T	uc003xfb.1	+	8	1076	c.726C>T	c.(724-726)ATC>ATT	p.I242I	DPYSL2_uc003xfa.2_Silent_p.I347I|DPYSL2_uc011lag.1_Silent_p.I242I|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Silent_p.I206I	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	242					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		CCATCACCATCGCCAACCAGA	0.582000												
RNF122	79845	broad.mit.edu	37	8	33416240	33416240	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:33416240C>T	uc003xjo.1	-	2	477	c.75G>A	c.(73-75)ATG>ATA	p.M25I		NM_024787	NP_079063	Q9H9V4	RN122_HUMAN	ring finger protein 122	25						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		TGATGGGTGGCATCGAGCAGG	0.478000												
TACC1	6867	broad.mit.edu	37	8	38699879	38699879	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:38699879G>A	uc010lwp.2	+	10	2414	c.2035G>A	c.(2035-2037)GCT>ACT	p.A679T	TACC1_uc003xma.2_Missense_Mutation_p.A117T|TACC1_uc003xlz.2_Missense_Mutation_p.A484T|TACC1_uc003xmc.3_Missense_Mutation_p.A483T|TACC1_uc011lbz.1_Missense_Mutation_p.A666T|TACC1_uc003xmb.3_Missense_Mutation_p.A605T|TACC1_uc003xmf.3_Missense_Mutation_p.A269T|TACC1_uc011lca.1_Missense_Mutation_p.A662T|TACC1_uc011lcb.1_Missense_Mutation_p.A455T|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Missense_Mutation_p.A496T|TACC1_uc010lwq.2_Missense_Mutation_p.A495T	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	679					cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			ACAGGCCCTGGCTGACCTTAA	0.453000												
C8orf40	114926	broad.mit.edu	37	8	42407698	42407698	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:42407698G>A	uc011lcv.1	+	4	320	c.271G>A	c.(271-273)GAC>AAC	p.D91N	C8orf40_uc003xph.2_Missense_Mutation_p.D91N|C8orf40_uc003xpg.2_Missense_Mutation_p.D91N|C8orf40_uc010lxo.2_Missense_Mutation_p.D91N	NM_001135676	NP_001129148	Q96E16	CH040_HUMAN	hypothetical protein LOC114926	91						cytoplasm|integral to membrane|nucleolus					0	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AAGAAAGTACGACTATCAGCA	0.338000												
KIAA0146	23514	broad.mit.edu	37	8	48625354	48625354	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:48625354T>C	uc003xqd.2	+	15	2117	c.2108T>C	c.(2107-2109)GTG>GCG	p.V703A	KIAA0146_uc011ldb.1_Missense_Mutation_p.V703A|KIAA0146_uc010lxs.2_Missense_Mutation_p.V178A|KIAA0146_uc011ldc.1_Missense_Mutation_p.V633A|KIAA0146_uc011ldd.1_Missense_Mutation_p.V643A|KIAA0146_uc003xqe.2_Missense_Mutation_p.V178A|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.V392A|KIAA0146_uc010lxt.2_Missense_Mutation_p.V392A|KIAA0146_uc011ldf.1_Missense_Mutation_p.V208A|KIAA0146_uc011ldg.1_Missense_Mutation_p.V193A|KIAA0146_uc003xqg.1_5'Flank	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	703											0		Lung NSC(58;0.175)				CCCTTGTGTGTGCTGGGCTCT	0.607000												
DNAJC5B	85479	broad.mit.edu	37	8	66988980	66988980	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:66988980G>A	uc003xvs.1	+	4	496	c.205G>A	c.(205-207)GCA>ACA	p.A69T	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	69	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			CAACGCCCACGCAATACTTAC	0.428000												
NCOA2	10499	broad.mit.edu	37	8	71071833	71071833	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:71071833C>T	uc003xyn.1	-	10	1193	c.1031G>A	c.(1030-1032)GGC>GAC	p.G344D		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	344					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AACAAGAGTGCCATCAGACAA	0.398000			T	RUNXBP2	AML							
LRRCC1	85444	broad.mit.edu	37	8	86042248	86042248	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:86042248C>T	uc003ycw.2	+	11	1875	c.1721C>T	c.(1720-1722)GCG>GTG	p.A574V	LRRCC1_uc010lzz.1_RNA|LRRCC1_uc010maa.1_Missense_Mutation_p.A275V|LRRCC1_uc003ycx.2_Missense_Mutation_p.A481V|LRRCC1_uc003ycy.2_Missense_Mutation_p.A554V	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	574	Potential.				cell division|mitosis	centriole|nucleus					0						AGAGAACAAGCGCAACAACTT	0.368000												
DCAF4L2	138009	broad.mit.edu	37	8	88885339	88885339	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:88885339T>C	uc003ydz.2	-	1	958	c.861A>G	c.(859-861)TCA>TCG	p.S287S		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	287	WD 1.									ovary(1)	1						TCATGTCTGATGACACCAGGA	0.507000												
KIAA1429	25962	broad.mit.edu	37	8	95500956	95500956	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:95500956T>C	uc003ygo.1	-	24	5430	c.5417A>G	c.(5416-5418)CAT>CGT	p.H1806R	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1806					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GGAGCGTACATGACGACCTCT	0.443000												
RGS22	26166	broad.mit.edu	37	8	101011627	101011627	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:101011627A>C	uc003yjb.1	-	19	3007	c.2812T>G	c.(2812-2814)TGG>GGG	p.W938G	RGS22_uc003yja.1_Missense_Mutation_p.W757G|RGS22_uc003yjc.1_Missense_Mutation_p.W926G	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	938	RGS 1.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ATCTTCCCCCAGCCACCACTT	0.363000												
SYBU	55638	broad.mit.edu	37	8	110587336	110587336	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:110587336G>A	uc003ynj.3	-	7	1954	c.1791C>T	c.(1789-1791)GGC>GGT	p.G597G	SYBU_uc003yni.3_Silent_p.G594G|SYBU_uc003ynk.3_Silent_p.G478G|SYBU_uc010mco.2_Silent_p.G596G|SYBU_uc003ynl.3_Silent_p.G596G|SYBU_uc010mcp.2_Silent_p.G597G|SYBU_uc010mcq.2_Silent_p.G597G|SYBU_uc003yno.3_Silent_p.G478G|SYBU_uc010mcr.2_Silent_p.G597G|SYBU_uc003ynm.3_Silent_p.G596G|SYBU_uc003ynn.3_Silent_p.G596G|SYBU_uc010mcs.2_Silent_p.G478G|SYBU_uc010mct.2_Silent_p.G597G|SYBU_uc010mcu.2_Silent_p.G596G|SYBU_uc003ynp.3_Silent_p.G529G|SYBU_uc010mcv.2_Silent_p.G597G|SYBU_uc003ynh.3_Silent_p.G391G|SYBU_uc011lhw.1_Silent_p.G467G	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	597						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						GCCTCACGACGCCCCCGCGAG	0.597000												
MTSS1	9788	broad.mit.edu	37	8	125565501	125565501	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:125565501C>T	uc003yrk.2	-	14	2534	c.2000G>A	c.(1999-2001)GGC>GAC	p.G667D	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_Missense_Mutation_p.G316D|MTSS1_uc011lin.1_Missense_Mutation_p.G441D|MTSS1_uc011lio.1_Missense_Mutation_p.G557D|MTSS1_uc003yri.2_Missense_Mutation_p.G385D|MTSS1_uc003yrj.2_Missense_Mutation_p.G642D|MTSS1_uc003yrl.2_Missense_Mutation_p.G671D	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	667	Pro-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GGAAGCTTGGCCGCTCCACAT	0.612000												
FAM135B	51059	broad.mit.edu	37	8	139163507	139163507	+	Silent	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:139163507A>G	uc003yuy.2	-	13	3382	c.3211T>C	c.(3211-3213)TTG>CTG	p.L1071L	FAM135B_uc003yux.2_Silent_p.L972L|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.L633L|FAM135B_uc003yvb.2_Silent_p.L633L	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1071										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AAGGATCCCAAAGGCTGATGG	0.532000										HNSCC(54;0.14)		
FLJ43860	389690	broad.mit.edu	37	8	142500233	142500233	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:142500233G>A	uc003ywi.2	-	5	762	c.681C>T	c.(679-681)GGC>GGT	p.G227G	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	227							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			AGGACAGGACGCCCATCACGT	0.637000												
RHPN1	114822	broad.mit.edu	37	8	144462879	144462879	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:144462879G>A	uc003yyb.2	+	11	1470	c.1337G>A	c.(1336-1338)CGC>CAC	p.R446H		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	471	BRO1.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			ACGCTGCAGCGCTCACTGGCC	0.687000												
AK3	50808	broad.mit.edu	37	9	4719182	4719182	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:4719182C>T	uc003ziq.1	-	3	537	c.397G>A	c.(397-399)GCC>ACC	p.A133T	AK3_uc003zip.1_RNA|AK3_uc011lma.1_Missense_Mutation_p.A93T|AK3_uc003zir.1_Missense_Mutation_p.A63T	NM_016282	NP_057366	Q9UIJ7	KAD3_HUMAN	adenylate kinase 3	133					blood coagulation	mitochondrial matrix	ATP binding|GTP binding|nucleoside triphosphate adenylate kinase activity			ovary(2)	2	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0302)		CGGCCACTGGCGGGATGAATC	0.473000												
KDM4C	23081	broad.mit.edu	37	9	6888045	6888045	+	Silent	SNP	T	T	C	rs35244873	byFrequency	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:6888045T>C	uc003zkh.2	+	7	1345	c.765T>C	c.(763-765)TAT>TAC	p.Y255Y	KDM4C_uc010mhu.2_Silent_p.Y277Y|KDM4C_uc010mhw.2_Silent_p.Y255Y|KDM4C_uc011lmi.1_Silent_p.Y255Y|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Silent_p.Y255Y|KDM4C_uc011lmk.1_Silent_p.Y74Y	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	255	JmjC.				positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						TGAAGAAATATGGTATTCCCT	0.333000												
MPDZ	8777	broad.mit.edu	37	9	13143471	13143471	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:13143471G>A	uc010mia.1	-	26	3891	c.3834C>T	c.(3832-3834)GCC>GCT	p.A1278A	MPDZ_uc010mhx.2_Intron|MPDZ_uc011lmm.1_Intron|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Silent_p.A1278A|MPDZ_uc010mhz.2_Intron|MPDZ_uc011lmn.1_Intron|MPDZ_uc003zlb.3_Silent_p.A1278A	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1278					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		CAACCTTGTCGGCGTTGATTT	0.428000												
FREM1	158326	broad.mit.edu	37	9	14805124	14805124	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:14805124C>T	uc003zlm.2	-	19	3891	c.3301G>A	c.(3301-3303)GCT>ACT	p.A1101T	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1101	CSPG 7.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		ATGTGAAAAGCGTTCATGTCT	0.413000												
ADAMTSL1	92949	broad.mit.edu	37	9	18574213	18574213	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:18574213T>C	uc003zne.3	+	4	550	c.423T>C	c.(421-423)GGT>GGC	p.G141G	ADAMTSL1_uc003znb.2_Silent_p.G141G|ADAMTSL1_uc003znc.3_Silent_p.G141G	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	141						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TCTTAGATGGTACGCGTTGCT	0.448000												
KIAA1797	54914	broad.mit.edu	37	9	20874757	20874757	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:20874757C>T	uc003zog.1	+	21	2631	c.2268C>T	c.(2266-2268)GGC>GGT	p.G756G	KIAA1797_uc003zoh.1_Silent_p.G192G	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	756						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		CAGTTCCTGGCTCTTGCTATC	0.408000												
IFNA7	3444	broad.mit.edu	37	9	21202157	21202157	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:21202157C>T	uc003zop.1	-	1	48	c.8G>A	c.(7-9)CGG>CAG	p.R3Q	IFNA14_uc003zoo.1_Intron	NM_021057	NP_066401	P01567	IFNA7_HUMAN	interferon, alpha 7 precursor	3					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		AGAAAAGGACCGGGCCATTGG	0.507000												
UNC13B	10497	broad.mit.edu	37	9	35382432	35382432	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:35382432C>T	uc003zwq.2	+	20	2779	c.2487C>T	c.(2485-2487)AAC>AAT	p.N829N	UNC13B_uc003zwr.2_Silent_p.N829N	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	829					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CCAACATCAACGCCTACTATG	0.483000												
FAM122A	116224	broad.mit.edu	37	9	71395740	71395740	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:71395740C>T	uc004agw.1	+	1	777	c.660C>T	c.(658-660)GGC>GGT	p.G220G	PIP5K1B_uc004agu.2_Intron|PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_Intron	NM_138333	NP_612206	Q96E09	F122A_HUMAN	hypothetical protein LOC116224	220											0						TTTTCCAGGGCATCACCAACA	0.453000												
TLE4	7091	broad.mit.edu	37	9	82323671	82323671	+	Silent	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:82323671T>C	uc004ald.2	+	14	2157	c.1308T>C	c.(1306-1308)GCT>GCC	p.A436A	TLE4_uc004alc.2_Silent_p.A411A|TLE4_uc010mpr.2_Silent_p.A290A|TLE4_uc004ale.2_Silent_p.A48A|TLE4_uc011lsq.1_Silent_p.A379A|TLE4_uc010mps.2_Silent_p.A335A|TLE4_uc004alf.2_Silent_p.A350A	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						ccgccgccgctgctgctgctg	0.433000												
PTPDC1	138639	broad.mit.edu	37	9	96859844	96859844	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:96859844G>T	uc004auf.1	+	7	1174	c.834G>T	c.(832-834)GAG>GAT	p.E278D	PTPDC1_uc004aug.1_Missense_Mutation_p.E278D|PTPDC1_uc004auh.1_Missense_Mutation_p.E330D|PTPDC1_uc010mrj.1_Missense_Mutation_p.E332D|PTPDC1_uc010mri.1_Missense_Mutation_p.E330D	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	278							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						ATGGTTATGAGGCACGACTTC	0.468000												
ZNF462	58499	broad.mit.edu	37	9	109687613	109687613	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:109687613G>A	uc004bcz.2	+	3	1709	c.1420G>A	c.(1420-1422)GAA>AAA	p.E474K	ZNF462_uc010mto.2_Missense_Mutation_p.E322K|ZNF462_uc004bda.2_Missense_Mutation_p.E322K	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	474	C2H2-type 5.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CAAATGTGACGAATGTCCGTT	0.473000												
MUSK	4593	broad.mit.edu	37	9	113550073	113550073	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:113550073G>A	uc004bey.2	+	13	1980	c.1882G>A	c.(1882-1884)GCC>ACC	p.A628T	MUSK_uc004bez.1_Missense_Mutation_p.A208T	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	628	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						GAGGGAGGCAGCCCTCATGGC	0.438000												
DAB2IP	153090	broad.mit.edu	37	9	124530798	124530798	+	Silent	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:124530798C>A	uc004bln.2	+	10	1770	c.1701C>A	c.(1699-1701)ATC>ATA	p.I567I	DAB2IP_uc004blo.2_Silent_p.I471I|DAB2IP_uc004blp.2_Silent_p.I22I	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	595					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						TGCTGGAGATCTCCAACCCCG	0.587000												
NEK6	10783	broad.mit.edu	37	9	127089652	127089652	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:127089652G>A	uc004bog.2	+	7	699	c.550G>A	c.(550-552)GGC>AGC	p.G184S	NEK6_uc004bof.2_Missense_Mutation_p.G202S|NEK6_uc004boh.2_Missense_Mutation_p.G218S|NEK6_uc010mwj.2_Missense_Mutation_p.G137S|NEK6_uc010mwk.2_Missense_Mutation_p.G184S|NEK6_uc004boi.2_Missense_Mutation_p.G184S	NM_014397	NP_055212	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6 isoform 2	184	Protein kinase.				apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|kidney(1)	3						CACAGCCACGGGCGTCGTGAA	0.627000												
GOLGA1	2800	broad.mit.edu	37	9	127644063	127644063	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:127644063C>A	uc004bpc.2	-	21	2478	c.2136G>T	c.(2134-2136)GAG>GAT	p.E712D	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	712	GRIP.					Golgi cisterna membrane				ovary(1)	1						AGCCCTTTACCTCGGATTCGC	0.502000												
C9orf119	375757	broad.mit.edu	37	9	131038469	131038469	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:131038469C>A	uc004bup.2	+	1	45	c.45C>A	c.(43-45)AGC>AGA	p.S15R	GOLGA2_uc011maw.1_5'Flank|GOLGA2_uc010mxw.2_5'Flank|GOLGA2_uc004bul.1_5'Flank|C9orf119_uc010mxx.1_Missense_Mutation_p.S15R	NM_001040011	NP_001035100	Q1ZZU3	SWI5_HUMAN	hypothetical protein LOC375757	15					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0						ACAACAAAAGCTGCGCACGCA	0.632000												
RAPGEF1	2889	broad.mit.edu	37	9	134459791	134459791	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:134459791C>T	uc004cbc.2	-	21	2893	c.2763G>A	c.(2761-2763)CGG>CGA	p.R921R	RAPGEF1_uc004cbb.2_Silent_p.R939R	NM_005312	NP_005303	Q13905	RPGF1_HUMAN	guanine nucleotide-releasing factor 2 isoform a	921	Ras-GEF.				activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	guanyl-nucleotide exchange factor activity|SH3 domain binding			lung(3)|ovary(2)|breast(1)|skin(1)	7		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		TATTCAGCTTCCGCAAGTGCT	0.642000												
BARHL1	56751	broad.mit.edu	37	9	135458453	135458453	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:135458453G>A	uc004cbp.1	+	1	461	c.269G>A	c.(268-270)CGC>CAC	p.R90H		NM_020064	NP_064448	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	90						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		GCCCAGTCGCGCACCGTCACC	0.687000												
RALGDS	5900	broad.mit.edu	37	9	135977061	135977061	+	Missense_Mutation	SNP	G	G	A	rs143871051	byFrequency	TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:135977061G>A	uc004cco.2	-	16	2320	c.2300C>T	c.(2299-2301)ACG>ATG	p.T767M	RALGDS_uc004cct.1_5'Flank|RALGDS_uc004ccn.2_Translation_Start_Site|RALGDS_uc004ccp.2_RNA|RALGDS_uc004ccq.2_Missense_Mutation_p.T755M|RALGDS_uc004ccr.2_Missense_Mutation_p.T766M|RALGDS_uc011mcv.1_Missense_Mutation_p.T738M|RALGDS_uc004ccs.2_Missense_Mutation_p.T712M|RALGDS_uc011mcw.1_Missense_Mutation_p.T838M|RALGDS_uc004ccv.1_Silent_p.H594H|RALGDS_uc004ccu.1_Missense_Mutation_p.T536M	NM_006266	NP_006257	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	767					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			large_intestine(1)|lung(1)|ovary(1)	3				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		AGCCACGGGCGTGGTGGAGGC	0.652000			T	CIITA	PMBL|Hodgkin Lymphona|							
KCNT1	57582	broad.mit.edu	37	9	138650317	138650317	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:138650317A>G	uc011mdq.1	+	10	891	c.817A>G	c.(817-819)ATC>GTC	p.I273V	KCNT1_uc011mdr.1_Missense_Mutation_p.I100V|KCNT1_uc010nbf.2_Missense_Mutation_p.I225V|KCNT1_uc004cgo.1_Missense_Mutation_p.I22V	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	273						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		CCAGGTCCTCATCCTCTTCTG	0.627000												
PPP2R3B	28227	broad.mit.edu	37	X	295141	295141	+	Silent	SNP	G	G	A	rs144810281		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:295141G>A	uc004cpg.2	-	13	1890	c.1689C>T	c.(1687-1689)TAC>TAT	p.Y563Y	PPP2R3B_uc004cpf.2_Silent_p.Y164Y	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	563					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ATGCGTACTCGTACAGGTCCA	0.741000												
PIGA	5277	broad.mit.edu	37	X	15349629	15349629	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:15349629C>T	uc004cwr.2	-	2	524	c.424G>A	c.(424-426)GCC>ACC	p.A142T	PIGA_uc004cwq.2_Intron|PIGA_uc010nev.2_Intron|PIGA_uc004cws.2_Intron|PIGA_uc011miq.1_Intron|PIGA_uc010new.1_Intron	NM_002641	NP_002632	P37287	PIGA_HUMAN	phosphatidylinositol	142	Cytoplasmic (Potential).				C-terminal protein lipidation|positive regulation of metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity|protein binding				0	Hepatocellular(33;0.183)					ATTGTCTTGGCGTGGAAGAGA	0.468000												
MAGEB16	139604	broad.mit.edu	37	X	35821242	35821242	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:35821242C>T	uc010ngt.1	+	2	1208	c.929C>T	c.(928-930)GCG>GTG	p.A310V		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	310	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						TCTCAGTATGCGGAAGCTCTG	0.498000												
CASK	8573	broad.mit.edu	37	X	41379720	41379720	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:41379720G>A	uc004dfl.3	-	27	2765	c.2719C>T	c.(2719-2721)CTC>TTC	p.L907F	CASK_uc004dfj.3_Missense_Mutation_p.L452F|CASK_uc004dfk.3_Missense_Mutation_p.L727F|CASK_uc004dfm.3_Missense_Mutation_p.L884F|CASK_uc004dfn.3_Missense_Mutation_p.L883F	NM_003688	NP_003679	O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein	912					cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			ovary(3)|lung(2)|stomach(1)	6						GTGCACACGAGCTCAACAGCT	0.473000												
SUV39H1	6839	broad.mit.edu	37	X	48564698	48564698	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:48564698G>T	uc004dkn.2	+	4	916	c.871G>T	c.(871-873)GAC>TAC	p.D291Y	SUV39H1_uc011mmf.1_Missense_Mutation_p.D302Y|SUV39H1_uc011mmg.1_RNA	NM_003173	NP_003164	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1	291	Mediates interaction with MECOM (By similarity).|SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding				0						CCAGATCTACGACCGTCAGGG	0.587000												
WNK3	65267	broad.mit.edu	37	X	54276024	54276024	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:54276024C>A	uc004dtd.1	-	17	3196	c.2757G>T	c.(2755-2757)TTG>TTT	p.L919F	WNK3_uc004dtc.1_Missense_Mutation_p.L919F	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	919					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						CTATAGTGAGCAATGTGTCCC	0.398000												
UBQLN2	29978	broad.mit.edu	37	X	56591820	56591820	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:56591820T>C	uc004dus.2	+	1	1749	c.1514T>C	c.(1513-1515)GTC>GCC	p.V505A	UBQLN2_uc011moq.1_Intron	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	505	5.|12 X 3 AA tandem repeats of P-X-X.					cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						GGCCCTATAGTCCCTTTTACC	0.662000												
RGAG4	340526	broad.mit.edu	37	X	71351350	71351350	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:71351350G>A	uc010nlh.1	-	1	402	c.41C>T	c.(40-42)GCG>GTG	p.A14V	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank|NHSL2_uc010nli.2_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	14										ovary(2)|skin(1)	3	Renal(35;0.156)					GGCCACATTCGCCATGCGGAG	0.612000												
ERCC6L	54821	broad.mit.edu	37	X	71427426	71427426	+	Silent	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:71427426C>T	uc004eaq.1	-	2	1288	c.1191G>A	c.(1189-1191)ACG>ACA	p.T397T	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Silent_p.T274T	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	397					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					AAGGTGAGCGCGTCTCCATTA	0.403000												
CDX4	1046	broad.mit.edu	37	X	72674374	72674374	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:72674374C>T	uc011mqk.1	+	3	808	c.808C>T	c.(808-810)CGT>TGT	p.R270C		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	270						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					ATCTGCTGTTCGTGGATTTCA	0.433000												
SATL1	340562	broad.mit.edu	37	X	84363384	84363384	+	Silent	SNP	G	G	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:84363384G>A	uc011mqx.1	-	1	591	c.591C>T	c.(589-591)GGC>GGT	p.G197G	SATL1_uc004een.2_Silent_p.G197G	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	10	Gln-rich.						N-acetyltransferase activity			breast(2)	2						GTTGTTGCACGCCTGGTTGCC	0.572000												
TRMT2B	79979	broad.mit.edu	37	X	100274338	100274338	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:100274338A>G	uc004egq.2	-	11	1522	c.1223T>C	c.(1222-1224)CTG>CCG	p.L408P	TRMT2B_uc004egp.2_RNA|TRMT2B_uc004egr.2_Missense_Mutation_p.L408P|TRMT2B_uc004egs.2_Missense_Mutation_p.L408P|TRMT2B_uc004egt.2_Missense_Mutation_p.L408P|TRMT2B_uc004egu.2_Missense_Mutation_p.L289P|TRMT2B_uc004egv.2_Missense_Mutation_p.L363P	NM_024917	NP_079193	Q96GJ1	TRM2_HUMAN	TRM2 tRNA methyltransferase 2 homolog B	408							tRNA (uracil-5-)-methyltransferase activity			ovary(1)	1						TGACTTTAGCAGCCCTGGCAA	0.483000												
TCEAL6	158931	broad.mit.edu	37	X	101396155	101396155	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:101396155G>T	uc004eiq.2	-	3	310	c.149C>A	c.(148-150)GCT>GAT	p.A50D		NM_001006938	NP_001006939	Q6IPX3	TCAL6_HUMAN	transcription elongation factor A (SII)-like 6	50	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						ctctccctcagcctttcgctt	0.214000												
MYLK	4638	broad.mit.edu	37	3	123368044	123368044	+	Splice_Site	DEL	G	G	-	rs138786404		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:123368043_123368043TG>T	uc003ego.3	-	25	4571	c.4289_splice	c.e25-1	p.E1430_splice	MYLK_uc010hrr.3_Splice_Site|MYLK_uc011bjv.2_Splice_Site_p.E230_splice|MYLK_uc011bjw.2_Splice_Site_p.E1430_splice|MYLK_uc003egp.3_Splice_Site_p.E1361_splice|MYLK_uc003egq.3_Splice_Site_p.E1430_splice|MYLK_uc003egr.3_Splice_Site_p.E1361_splice|MYLK_uc003egs.3_Splice_Site_p.E1254_splice	NM_053025	NP_444253	Q15746	MYLK_HUMAN	Homo sapiens myosin light chain kinase (MYLK), transcript variant 1, mRNA.	1430	Actin-binding (calcium/calmodulin- insensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	ATP binding|actin binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTTCGGCTCTGGGGGGGGCA	0.622												
UHRF1BP1L	23074	broad.mit.edu	37	12	100451350	100451350	+	Splice_Site	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:100451349_100451349CT>C	uc001tgq.3	-	15	3653	c.3424_splice	c.e15+1	p.G1142_splice	UHRF1BP1L_uc001tgp.3_Splice_Site_p.G792_splice	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	Homo sapiens UHRF1 binding protein 1-like (UHRF1BP1L), transcript variant 1, mRNA.	1142										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						ATAACTTTACCTTTTTCCAAA	0.328												
SYCP2	10388	broad.mit.edu	37	20	58494655	58494655	+	Splice_Site	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:58494654_58494654TA>T	uc002yaz.3	-	5	437	c.298_splice	c.e5-1	p.M100_splice	SYCP2_uc010gju.1_Splice_Site_p.M1_splice	NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	Homo sapiens synaptonemal complex protein 2 (SYCP2), mRNA.	100					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GGCAACCATGTAAAAAAAGGA	0.294												
PKP3	11187	broad.mit.edu	37	11	399184	399184	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:399184delA	uc001lpc.2	+	5	1337	c.1261delA	c.(1261-1263)AAAfs	p.K421fs		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	421	ARM 3.				cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGAGCTTCGCAAAAATGTCAC	0.353												
BCL9	607	broad.mit.edu	37	1	147091501	147091502	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:147091500_147091501A>AC	uc001epq.3	+	7	2279_2280	c.1539_1540A>AC	c.(1537-1542)ggacccfs	p.G513fs	BCL9_uc010ozr.1_Frame_Shift_Ins_p.G439fs	NM_004326	NP_004317	O00512	BCL9_HUMAN	Homo sapiens B-cell CLL/lymphoma 9 (BCL9), mRNA.	513	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					TGGTCCGAGGACCCCCCCCTCC	0.579			T	"""IGH@, IGL@"""	B-ALL							
ADAMTSL4	54507	broad.mit.edu	37	1	150530506	150530507	+	Frame_Shift_Ins	INS	-	-	G	rs149280379		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:150530505_150530506T>TG	uc009wlw.3	+	13	2489_2490	c.2331_2332T>TG	c.(2329-2334)tttgggfs	p.F777fs	ADAMTSL4_uc001euw.3_Frame_Shift_Ins_p.F754fs|ADAMTSL4_uc001eux.3_Frame_Shift_Ins_p.F754fs|ADAMTSL4_uc010pcg.2_Frame_Shift_Ins_p.F715fs|ADAMTSL4_uc009wlx.3_5'UTR	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	Homo sapiens ADAMTS-like 4 (ADAMTSL4), transcript variant 1, mRNA.	754	TSP type-1 2.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding	p.F754L(1)		breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GGCAGGAATTTGGGGGGGGTGG	0.693												
ABL2	27	broad.mit.edu	37	1	179077894	179077895	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr1:179077893_179077894A>AT	uc001gmj.4	-	11	2795_2796	c.2508_2509T>AT	c.(2506-2511)aaatcafs	p.K836fs	ABL2_uc010pnf.2_Frame_Shift_Ins_p.K733fs|ABL2_uc010png.2_Frame_Shift_Ins_p.K712fs|ABL2_uc010pnh.2_Frame_Shift_Ins_p.K815fs|ABL2_uc001gmg.4_Frame_Shift_Ins_p.K718fs|ABL2_uc001gmi.4_Frame_Shift_Ins_p.K821fs|ABL2_uc010pne.2_Frame_Shift_Ins_p.K697fs	NM_007314	NP_009298	P42684	ABL2_HUMAN	Homo sapiens v-abl Abelson murine leukemia viral oncogene homolog 2 (ABL2), transcript variant b, mRNA.	836	F-actin-binding (By similarity).				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.K800fs*34(1)		breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CTTTCCTCTGATTTTTTTGGAA	0.525			T	ETV6	AML							
BCL11A	53335	broad.mit.edu	37	2	60689254	60689255	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:60689253_60689254A>AG	uc002sae.1	-	3	1021_1022	c.793_794T>CT	c.(793-795)ctgfs	p.L265fs	BCL11A_uc002sab.3_Frame_Shift_Ins_p.L265fs|BCL11A_uc002sac.3_Intron|BCL11A_uc010ypi.2_Intron|BCL11A_uc010ypj.2_Frame_Shift_Ins_p.L231fs|BCL11A_uc002sad.1_Frame_Shift_Ins_p.L113fs|BCL11A_uc002saf.1_Frame_Shift_Ins_p.L231fs	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	Homo sapiens B-cell CLL/lymphoma 11A (zinc finger protein) (BCL11A), transcript variant 1, mRNA.	265	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGGACTAAACAGGGGGGGAGTG	0.584			T	IGH@	B-CLL							
AFTPH	54812	broad.mit.edu	37	2	64778861	64778862	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:64778860_64778861T>TA	uc002sdc.3	+	0	284_285	c.252_253T>TA	c.(250-255)attaaafs	p.I84fs	AFTPH_uc002scz.3_Frame_Shift_Ins_p.I84fs|AFTPH_uc002sda.3_Frame_Shift_Ins_p.I84fs|AFTPH_uc002sdb.3_Frame_Shift_Ins_p.I84fs	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	Homo sapiens aftiphilin (AFTPH), transcript variant 1, mRNA.	84					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						TTAAGTCCATTAAAAATGGTAA	0.356												
MAP2	4133	broad.mit.edu	37	2	210561667	210561668	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:210561666_210561667T>TA	uc002vde.1	+	8	4661_4662	c.4413_4414T>TA	c.(4411-4416)gctaaafs	p.A1471fs	MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Frame_Shift_Ins_p.A1467fs	NM_002374	NP_002365	P11137	MAP2_HUMAN	Homo sapiens microtubule-associated protein 2 (MAP2), transcript variant 1, mRNA.	1471					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity	p.T1474fs*14(1)		breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CTGAACTTGCTAAAAAAACAGA	0.366												
DIS3L2	129563	broad.mit.edu	37	2	233194613	233194613	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr2:233194612_233194612AC>A	uc010fxz.3	+	14	2105	c.1829_1829AC>A	c.(1828-1830)cacfs	p.H610fs	DIS3L2_uc002vsm.4_Non-coding_Transcript|DIS3L2_uc002vso.3_Non-coding_Transcript	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	Homo sapiens DIS3 mitotic control homolog (S. cerevisiae)-like 2 (DIS3L2), mRNA.	610							RNA binding|exonuclease activity|ribonuclease activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CTGCGCCGGCACCCCCCGCCC	0.642												
MLH1	4292	broad.mit.edu	37	3	37053348	37053348	+	Frame_Shift_Del	DEL	A	A	-	rs35847123		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:37053347_37053347TA>T	uc003cgl.3	+	6	780	c.582_582TA>T	c.(580-582)gttfs	p.V194fs	MLH1_uc011aye.2_5'UTR|MLH1_uc011ayb.2_5'UTR|MLH1_uc010hge.3_Frame_Shift_Del_p.V194fs|MLH1_uc011ayc.2_Frame_Shift_Del_p.V96fs|MLH1_uc011ayd.2_5'UTR|MLH1_uc003cgo.3_5'UTR|MLH1_uc003cgn.4_5'UTR|MLH1_uc010hgg.1_5'Flank|MLH1_uc010hgh.1_5'Flank|MLH1_uc010hgi.1_5'Flank|MLH1_uc010hgj.1_5'Flank|MLH1_uc010hgk.3_5'Flank|MLH1_uc010hgl.1_5'Flank	NM_000249	NP_001161091	P40692	MLH1_HUMAN	Homo sapiens mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 1, mRNA.	194					mismatch repair|somatic hypermutation of immunoglobulin genes	MutLalpha complex|MutLbeta complex|chiasma|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						GTTTCTCAGTTAAAAAAGTAA	0.343		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome			
ZNF197	10168	broad.mit.edu	37	3	44684226	44684226	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:44684225_44684225GA>G	uc003cnm.3	+	5	1809	c.1603_1603GA>G	c.(1603-1605)gaafs	p.E535fs	ZNF197_uc003cnn.3_Intron|ZNF197_uc003cno.3_Intron|ZNF197_uc003cnp.3_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	Homo sapiens zinc finger protein 197 (ZNF197), transcript variant 1, mRNA.	535					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		CCACTCTGGGGAAAAACCCTA	0.433												
ADAMTS9	56999	broad.mit.edu	37	3	64532503	64532503	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:64532502_64532502TG>T	uc003dmg.3	-	31	5028	c.4996_4996CA>A	c.(4996-4998)agtfs	p.S1666fs	ADAMTS9_uc011bfo.2_Frame_Shift_Del_p.S1638fs|ADAMTS9_uc011bfp.1_Frame_Shift_Del_p.S577fs	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), mRNA.	1666	TSP type-1 14.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGGTGAACACTGGGGGGCTGC	0.537												
EPHA3	2042	broad.mit.edu	37	3	89468398	89468398	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr3:89468397_89468397CA>C	uc003dqy.3	+	10	2156	c.1931_1931CA>C	c.(1930-1932)tcafs	p.S644fs	EPHA3_uc021xbf.1_Frame_Shift_Del_p.S644fs	NM_005233	NP_005224	P29320	EPHA3_HUMAN	Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA.	644	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		AAACTTCCTTCAAAAAAAGAG	0.393										TSP Lung(6;0.00050)		
ZBTB49	166793	broad.mit.edu	37	4	4303754	4303754	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:4303753_4303753GT>G	uc003ghu.3	+	2	365	c.190_190GT>G	c.(190-192)gttfs	p.V64fs	ZBTB49_uc003ghv.3_Intron|ZBTB49_uc010icy.3_Non-coding_Transcript|ZBTB49_uc010icz.3_5'Flank	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	Homo sapiens zinc finger and BTB domain containing 49 (ZBTB49), mRNA.	64	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						GAAGAATGATGTTTTTCACTT	0.353												
PROL1	58503	broad.mit.edu	37	4	71275496	71275498	+	In_Frame_Del	DEL	ACA	ACA	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:71275495_71275497TACA>T	uc003hfi.3	+	2	624_626	c.450_452TACA>T	c.(448-453)gataca>gaTa	p.T152del		NM_021225	NP_067048	Q99935	PROL1_HUMAN	Homo sapiens proline rich, lacrimal 1 (PROL1), mRNA.	152	Thr-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				CCACCGCAGATACAACAATCACC	0.443												
CFI	3426	broad.mit.edu	37	4	110687927	110687927	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr4:110687926_110687926AT>A	uc011cft.2	-	1	320	c.112_112AT>T	c.(112-114)tatfs	p.Y38fs	CFI_uc003hzr.4_Frame_Shift_Del_p.Y38fs	NM_000204	NP_000195	P05156	CFAI_HUMAN	Homo sapiens complement factor I (CFI), mRNA.	38					complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		AGGTGAGTATATTTTTTTGCT	0.398												
APC	324	broad.mit.edu	37	5	112176676	112176677	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:112176675_112176676C>CA	uc003kpz.4	+	16	5577_5578	c.5384_5385C>CA	c.(5383-5385)tcafs	p.S1795fs	APC_uc011cvt.2_Frame_Shift_Ins_p.S1777fs|APC_uc003kpy.4_Frame_Shift_Ins_p.S1795fs|APC_uc010jbz.3_Frame_Shift_Ins_p.S1512fs|APC_uc010jca.3_Frame_Shift_Ins_p.S1095fs	NM_001127510	NP_001120982	P25054	APC_HUMAN	Homo sapiens adenomatous polyposis coli (APC), transcript variant 2, mRNA.	1795	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|adherens junction|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.N1797fs*2(2)|p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AATGCAGACTCAAAAAATAATT	0.307		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)		
TCF7	6932	broad.mit.edu	37	5	133473765	133473765	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr5:133473764_133473764GC>G	uc003kyt.3	+	3	652	c.456_456GC>G	c.(454-456)cagfs	p.Q152fs	TCF7_uc003kyv.3_Frame_Shift_Del_p.Q37fs|TCF7_uc003kyw.3_Frame_Shift_Del_p.Q37fs|TCF7_uc003kyu.2_Frame_Shift_Del_p.Q37fs|TCF7_uc003kyy.3_Frame_Shift_Del_p.Q37fs|TCF7_uc003kyx.3_5'UTR|TCF7_uc003kyz.3_Frame_Shift_Del_p.Q37fs|TCF7_uc003kza.3_Frame_Shift_Del_p.Q37fs	NM_003202	NP_998813	P36402	TCF7_HUMAN	Homo sapiens transcription factor 7 (T-cell specific, HMG-box) (TCF7), transcript variant 1, mRNA.	152					Wnt receptor signaling pathway|cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(7)|lung(2)|skin(1)	12		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGCCAATCAGCCCCCCCACG	0.577												
F13A1	2162	broad.mit.edu	37	6	6266965	6266965	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:6266964_6266964GC>G	uc003mwv.3	-	3	521	c.398_398GC>C	c.(397-399)gccfs	p.A133fs	F13A1_uc011dib.2_Frame_Shift_Del_p.A70fs	NM_000129	NP_000120	P00488	F13A_HUMAN	Homo sapiens coagulation factor XIII, A1 polypeptide (F13A1), mRNA.	133					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity	p.A133D(2)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GACAATCTTGGCCCCCCACTT	0.493												
HIST1H2BC	8347	broad.mit.edu	37	6	26123922	26123923	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:26123921_26123922AAT>A	uc003ngk.4	-	0	233_234	c.211_212ATT>T	c.(211-213)tttfs	p.F71fs	HIST1H2BC_uc003ngl.3_Frame_Shift_Del_p.F71fs|HIST1H2AC_uc003ngm.3_5'Flank|HIST1H2AC_uc003ngo.3_5'Flank	NM_003526	NP_003517	P62807	H2B1C_HUMAN	Homo sapiens histone cluster 1, H2bc (HIST1H2BC), mRNA.	71					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	16						GATGCGCTCAAATATGTCGTTA	0.564												
HIST1H1D	3007	broad.mit.edu	37	6	26234932	26234932	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:26234931_26234931GT>G	uc003nhd.3	-	0	286	c.231_231AC>C	c.(229-231)aacfs	p.N77fs		NM_005320	NP_005311	P16402	H13_HUMAN	Homo sapiens histone cluster 1, H1d (HIST1H1D), mRNA.	77	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TACGGCTGTTGTTTTTTTCTA	0.527												
DNAH8	1769	broad.mit.edu	37	6	38831685	38831697	+	Frame_Shift_Del	DEL	AGTTTAACAGAAT	AGTTTAACAGAAT	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:38831684_38831696GAGTTTAACAGAAT>G	uc021yzh.1	+	44	6455_6467	c.6346_6358GAGTTTAACAGAAT>G	c.(6346-6360)gagtttaacagaattfs	p.E2116fs	DNAH8_uc003ooe.2_Frame_Shift_Del_p.E1899fs	NM_001206927	NP_001193856			Homo sapiens dynein, axonemal, heavy chain 8 (DNAH8), mRNA.											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTGTTTTGATGAGTTTAACAGAATTGAATTGCC	0.338												
ENPP4	22875	broad.mit.edu	37	6	46107942	46107942	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:46107941_46107941GA>G	uc003oxy.3	+	1	880	c.621_621GA>G	c.(619-621)ttgfs	p.L207fs		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	Homo sapiens ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) (ENPP4), mRNA.	207						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	18						GCAGAGTGTTGAAAAAAATAG	0.403												
REV3L	5980	broad.mit.edu	37	6	111695299	111695299	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr6:111695298_111695298CA>C	uc003puy.4	-	12	4601	c.4260_4260TG>G	c.(4258-4260)ttgfs	p.L1420fs	REV3L_uc003pux.4_Frame_Shift_Del_p.L1342fs|REV3L_uc003puz.4_Frame_Shift_Del_p.L1342fs	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	Homo sapiens REV3-like, catalytic subunit of DNA polymerase zeta (yeast) (REV3L), mRNA.	1420					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTTTGCAATGCAAAAAATTAG	0.393								DNA polymerases (catalytic subunits)				
HNRNPA2B1	3181	broad.mit.edu	37	7	26236526	26236527	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:26236525_26236526A>AT	uc003sxr.4	-	4	628_629	c.412_413T>AT	c.(412-414)attfs	p.I138fs	HNRNPA2B1_uc003sxs.4_Frame_Shift_Ins_p.I126fs	NM_031243	NP_112533	P22626	ROA2_HUMAN	Homo sapiens heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), transcript variant B1, mRNA.	138	RRM 2.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	RNA binding|nucleotide binding|protein binding|single-stranded telomeric DNA binding		HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22						AATGGTATCAATTTTTCCATAT	0.381			T	ETV1	prostate							
FIGNL1	63979	broad.mit.edu	37	7	50514060	50514060	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr7:50514059_50514059CT>C	uc003tpd.3	-	3	1297	c.927_927AG>G	c.(925-927)aagfs	p.K309fs	FIGNL1_uc003tpb.3_Frame_Shift_Del_p.K198fs|FIGNL1_uc003tpc.3_Frame_Shift_Del_p.K309fs|FIGNL1_uc003tpe.3_Frame_Shift_Del_p.K309fs|FIGNL1_uc010kyy.3_Frame_Shift_Del_p.K309fs|FIGNL1_uc022ada.1_Frame_Shift_Del_p.K309fs	NM_022116	NP_071399	Q6PIW4	FIGL1_HUMAN	Homo sapiens fidgetin-like 1 (FIGNL1), transcript variant 2, mRNA.	309					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GTTGGTGGTACTTTTTTTGCT	0.428												
RIMS2	9699	broad.mit.edu	37	8	104927779	104927779	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:104927778_104927778TA>T	uc003yls.3	+	4	1443	c.1202_1202TA>T	c.(1201-1203)gtafs	p.V401fs	RIMS2_uc003ylp.3_Frame_Shift_Del_p.V623fs|RIMS2_uc003ylw.2_Frame_Shift_Del_p.V431fs|RIMS2_uc003ylq.3_Frame_Shift_Del_p.V431fs|RIMS2_uc003ylr.3_Frame_Shift_Del_p.V478fs|RIMS2_uc003ylt.3_Frame_Shift_Del_p.V24fs|RIMS2_uc003ylu.1_Frame_Shift_Del_p.V14fs|RIMS2_uc003ylv.1_Frame_Shift_Del_p.V14fs	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	Homo sapiens regulating synaptic membrane exocytosis 2 (RIMS2), transcript variant 2, mRNA.	701					intracellular protein transport	cell junction|presynaptic membrane	Rab GTPase binding|metal ion binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATTACTAAAGTAAAAAAAGGA	0.323										HNSCC(12;0.0054)		
ZHX2	22882	broad.mit.edu	37	8	123965545	123965546	+	Frame_Shift_Ins	INS	-	-	A	rs141456875		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:123965544_123965545C>CA	uc022bag.1	+	0	1794_1795	c.1794_1795C>CA	c.(1792-1797)ggcaaafs	p.G598fs	ZHX2_uc003ypk.1_Frame_Shift_Ins_p.G598fs	NM_014943	NP_055758	Q9Y6X8	ZHX2_HUMAN	Homo sapiens zinc fingers and homeoboxes 2 (ZHX2), mRNA.	598						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			TGGGGTCTGGCAAAAAAGGCCA	0.574												
ZNF623	9831	broad.mit.edu	37	8	144732383	144732384	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr8:144732382_144732383C>CAG	uc003yzd.2	+	0	429_430	c.340_341C>CAG	c.(340-342)cagfs	p.Q114fs	ZNF623_uc011lkp.1_Frame_Shift_Ins_p.Q74fs|ZNF623_uc003yzc.2_Frame_Shift_Ins_p.Q74fs	NM_014789	NP_055604	O75123	ZN623_HUMAN	Homo sapiens zinc finger protein 623 (ZNF623), transcript variant 1, mRNA.	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.L113R(1)		endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCTTCTGCTTCAGAGAGAGCTC	0.480												
MPDZ	8777	broad.mit.edu	37	9	13125277	13125277	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:13125276_13125276CT>C	uc010mia.1	-	33	4803	c.4746_4746AG>G	c.(4744-4746)aagfs	p.K1582fs	MPDZ_uc003zky.4_Frame_Shift_Del_p.K144fs|MPDZ_uc010mib.3_Frame_Shift_Del_p.K287fs|MPDZ_uc010mhx.3_Frame_Shift_Del_p.K404fs|MPDZ_uc011lmm.2_Frame_Shift_Del_p.K441fs|MPDZ_uc003zkz.4_Frame_Shift_Del_p.K275fs|MPDZ_uc010mhz.3_Frame_Shift_Del_p.K1549fs|MPDZ_uc011lmn.2_Frame_Shift_Del_p.K1549fs|MPDZ_uc010mhy.3_Frame_Shift_Del_p.K1582fs|MPDZ_uc003zlb.4_Frame_Shift_Del_p.K1582fs	NM_003829	NP_003820	O75970	MPDZ_HUMAN	Homo sapiens multiple PDZ domain protein (MPDZ), mRNA.	1582					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		GGGAGCTGTTCTTTTTTTCTC	0.512												
TAF1L	138474	broad.mit.edu	37	9	32632794	32632794	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:32632793_32632793CA>C	uc003zrg.1	-	0	2875	c.2785_2785TG>G	c.(2785-2787)gccfs	p.A929fs	AX747113_uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	Homo sapiens TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like (TAF1L), mRNA.	929					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|TBP-class protein binding|histone acetyltransferase activity|protein serine/threonine kinase activity	p.A929S(2)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCTTCTGGGGCAAAAAAGGAT	0.458												
COL15A1	1306	broad.mit.edu	37	9	101748038	101748039	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:101748037_101748038G>GA	uc004azb.1	+	2	497_498	c.291_292G>GA	c.(289-294)gtgaagfs	p.V97fs		NM_001855	NP_001846	P39059	COFA1_HUMAN	Homo sapiens collagen, type XV, alpha 1 (COL15A1), mRNA.	97	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				GCGTCGTGGTGAAGCCCAGCAG	0.634												
IKBKAP	8518	broad.mit.edu	37	9	111681575	111681576	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:111681574_111681575T>TC	uc004bdm.4	-	6	1127_1128	c.607_608A>GA	c.(607-609)gatfs	p.D203fs	IKBKAP_uc004bdl.3_5'Flank|IKBKAP_uc011lwc.2_Frame_Shift_Ins_p.D89fs|IKBKAP_uc010mtq.3_Intron	NM_003640	NP_003631	O95163	ELP1_HUMAN	Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP), mRNA.	203					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	DNA-directed RNA polymerase II, holoenzyme|cytoplasm|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AAACTGTCCATCCCCCCGCCAG	0.386												
DOLK	22845	broad.mit.edu	37	9	131708196	131708196	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr9:131708195_131708195TC>T	uc004bwr.3	-	0	1818	c.1388_1388GA>A	c.(1387-1389)gagfs	p.E463fs	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	Homo sapiens dolichol kinase (DOLK), mRNA.	463	CTP-binding.				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity			breast(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	11						CCAGCGGATCTCCCCCATGGT	0.547												
ANK3	288	broad.mit.edu	37	10	61823946	61823946	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:61823945_61823945AT>A	uc001jky.3	-	38	12759	c.12421_12421AT>T	c.(12421-12423)tggfs	p.W4141fs	ANK3_uc001jkw.3_Frame_Shift_Del_p.W662fs|ANK3_uc009xpa.3_Frame_Shift_Del_p.W662fs|ANK3_uc001jkx.3_Frame_Shift_Del_p.W706fs|ANK3_uc010qih.2_Frame_Shift_Del_p.W1529fs|ANK3_uc001jkz.4_Frame_Shift_Del_p.W1522fs|ANK3_uc001jkv.3_Frame_Shift_Del_p.W61fs	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	4141	Death.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGGTAACCCATTTTTTTAAT	0.308												
LZTS2	84445	broad.mit.edu	37	10	102762312	102762313	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:102762311_102762312ACT>A	uc001ksj.3	+	1	186_187	c.16_17ACT>A	c.(16-18)actfs	p.T6fs	LZTS2_uc010qpw.2_Frame_Shift_Del_p.T6fs|LZTS2_uc001ksk.3_Frame_Shift_Del_p.T6fs|LZTS2_uc001ksl.3_Frame_Shift_Del_p.T6fs|LZTS2_uc001ksm.3_Non-coding_Transcript	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	Homo sapiens leucine zipper, putative tumor suppressor 2 (LZTS2), mRNA.	6	Required for centrosomal localization (By similarity).				Wnt receptor signaling pathway|cell division|mitosis	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		CATTGTGCAGACTCTGCCAGTG	0.639												
DCLRE1A	9937	broad.mit.edu	37	10	115609826	115609826	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:115609825_115609825GT>G	uc001law.2	-	1	1957	c.1039_1039AC>C	c.(1039-1041)cgafs	p.R347fs		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	Homo sapiens DNA cross-link repair 1A (DCLRE1A), mRNA.	347					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		GGACCATGTCGTTTTTTAAAA	0.408								Other identified genes with known or suspected DNA repair function				
TRUB1	142940	broad.mit.edu	37	10	116730192	116730192	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:116730191_116730191GC>G	uc001lcd.3	+	4	649	c.588_588GC>G	c.(586-588)gtgfs	p.V196fs	TRUB1_uc010qsl.2_Frame_Shift_Del_p.V98fs|U6_uc021pzh.1_5'Flank	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	Homo sapiens TruB pseudouridine (psi) synthase homolog 1 (E. coli) (TRUB1), mRNA.	196					pseudouridine synthesis|tRNA processing		RNA binding|pseudouridine synthase activity			breast(2)|kidney(2)|large_intestine(1)|lung(5)|urinary_tract(2)	12		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		TAATGCAAGTGCCCCCCCTGT	0.318												
C10orf90	118611	broad.mit.edu	37	10	128193320	128193320	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr10:128193319_128193319TG>T	uc010qum.2	-	3	771	c.741_741CA>A	c.(739-741)ccafs	p.P247fs	C10orf90_uc001ljp.3_Frame_Shift_Del_p.P103fs|C10orf90_uc001ljq.3_Frame_Shift_Del_p.P150fs|C10orf90_uc009yao.2_Frame_Shift_Del_p.P247fs|C10orf90_uc001ljs.1_Frame_Shift_Del_p.P103fs	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	Homo sapiens chromosome 10 open reading frame 90 (C10orf90), mRNA.	150										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		GGGCGCGGGCTGGGGGGCCCA	0.697											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
PTPRJ	5795	broad.mit.edu	37	11	48157816	48157816	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:48157815_48157815TG>T	uc001ngp.4	+	8	2195	c.1840_1840TG>T	c.(1840-1842)tggfs	p.W614fs	PTPRJ_uc010rhr.1_Frame_Shift_Del_p.W59fs	NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, J (PTPRJ), transcript variant 1, mRNA.	614	Fibronectin type-III 6.				contact inhibition|negative regulation of MAP kinase activity|negative regulation of T cell receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GGACCACGTCTGGGGGGACCC	0.517												
NUMA1	4926	broad.mit.edu	37	11	71724190	71724190	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:71724189_71724189GC>G	uc001orl.1	-	14	4532	c.4360_4360GC>C	c.(4360-4362)ctgfs	p.L1454fs	NUMA1_uc009ysw.1_Frame_Shift_Del_p.L1017fs|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Frame_Shift_Del_p.L1454fs|NUMA1_uc001orn.2_Frame_Shift_Del_p.L1017fs|NUMA1_uc009ysx.1_Frame_Shift_Del_p.L1454fs|NUMA1_uc001oro.1_Frame_Shift_Del_p.L1454fs	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	Homo sapiens nuclear mitotic apparatus protein 1 (NUMA1), mRNA.	1454					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CGCTCACCCAGCCCCCGGTTC	0.627			T	RARA	APL							
TRIM29	23650	broad.mit.edu	37	11	120008403	120008403	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr11:120008402_120008402GC>G	uc001pwz.3	-	0	462	c.338_338GC>C	c.(337-339)gctfs	p.A113fs	TRIM29_uc001pxa.3_Non-coding_Transcript	NM_012101	NP_036233	Q14134	TRI29_HUMAN	Homo sapiens tripartite motif containing 29 (TRIM29), mRNA.	113					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CTTCTTGGCAGCCCCCAGCTG	0.597												
MLL2	8085	broad.mit.edu	37	12	49447032	49447032	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:49447031_49447031GT>G	uc001rta.4	-	6	913	c.913_913AC>C	c.(913-915)ccafs	p.P305fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2), mRNA.	305	Cys-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(38)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(121)|kidney(35)|large_intestine(22)|lung(78)|ovary(3)|pancreas(2)|prostate(13)|skin(7)|stomach(3)|upper_aerodigestive_tract(9)|urinary_tract(5)	366						TCCATGGGTGGTTTTAGGCAG	0.478			"""N, F, Mis"""		"""medulloblastoma, renal"""					HNSCC(34;0.089)		
KRT79	338785	broad.mit.edu	37	12	53225246	53225246	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:53225245_53225245TC>T	uc001sbb.3	-	1	676	c.643_643GA>A	c.(643-645)aggfs	p.R215fs	KRT79_uc001sba.3_5'Flank	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	Homo sapiens keratin 79 (KRT79), mRNA.	215	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GAGTCCAGCCTCCCCCGCTCG	0.617												
LGR5	8549	broad.mit.edu	37	12	71977713	71977713	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:71977712_71977712GT>G	uc001swl.3	+	17	1970	c.1922_1922GT>G	c.(1921-1923)ggtfs	p.G641fs	LGR5_uc001swm.3_Frame_Shift_Del_p.G617fs|LGR5_uc021rar.1_Frame_Shift_Del_p.G569fs|LGR5_uc001swn.1_Intron	NM_003667	NP_003658	O75473	LGR5_HUMAN	Homo sapiens leucine-rich repeat containing G protein-coupled receptor 5 (LGR5), mRNA.	641						integral to plasma membrane	protein-hormone receptor activity	p.I640T(1)	NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						CATGTCATTGGTTTTTTGTCC	0.493												
UHRF1BP1L	23074	broad.mit.edu	37	12	100451350	100451350	+	Splice_Site	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:100451349_100451349CT>C	uc001tgq.3	-	15	3653	c.3424_splice	c.e15+1	p.G1142_splice	UHRF1BP1L_uc001tgp.3_Splice_Site_p.G792_splice	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	Homo sapiens UHRF1 binding protein 1-like (UHRF1BP1L), transcript variant 1, mRNA.	1142										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						ATAACTTTACCTTTTTCCAAA	0.328												
UTP20	27340	broad.mit.edu	37	12	101682763	101682764	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:101682762_101682763T>TA	uc001tia.1	+	5	696_697	c.540_541T>TA	c.(538-543)cataaafs	p.H180fs	UTP20_uc009ztz.1_Frame_Shift_Ins_p.H180fs	NM_014503	NP_055318	O75691	UTP20_HUMAN	Homo sapiens UTP20, small subunit (SSU) processome component, homolog (yeast) (UTP20), mRNA.	180					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						TCCTGGCTCATAAAAAACTACA	0.277												
C12orf51	283450	broad.mit.edu	37	12	112690349	112690350	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:112690348_112690349A>AG	uc021reb.1	-	22	3425_3426	c.3029_3030T>CT	c.(3028-3030)cctfs	p.P1010fs	C12orf51_uc010syk.1_Intron|C12orf51_uc001tts.2_Intron|C12orf51_uc001ttt.3_Intron	NM_001109662	NP_001103132			Homo sapiens chromosome 12 open reading frame 51 (C12orf51), mRNA.											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(6)|large_intestine(16)|lung(49)|ovary(4)|prostate(1)|urinary_tract(6)	100						AATTTAAGGAAGGGGGGGAAAT	0.396												
UBC	7316	broad.mit.edu	37	12	125396267	125396267	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr12:125396266_125396266AC>A	uc001ugs.4	-	1	2510	c.2052_2052GT>T	c.(2050-2052)ggtfs	p.G684fs	UBC_uc001ugr.3_Non-coding_Transcript|UBC_uc001ugt.3_Frame_Shift_Del_p.G532fs|UBC_uc001ugu.1_Frame_Shift_Del_p.G608fs|UBC_uc001ugv.3_Frame_Shift_Del_p.G152fs|UBC_uc021rge.1_Frame_Shift_Del_p.G684fs	NM_021009	NP_066289	P0CG48	UBC_HUMAN	Homo sapiens ubiquitin C (UBC), mRNA.	684	Ubiquitin-like 9.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|JNK cascade|M/G1 transition of mitotic cell cycle|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|S phase of mitotic cell cycle|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|innate immune response|mRNA metabolic process|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		AAACTTAGACACCCCCCCTCA	0.413												
ZC3H13	23091	broad.mit.edu	37	13	46585554	46585554	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr13:46585553_46585553CT>C	uc010tfw.1	-	4	591	c.585_585AG>G	c.(583-585)aagfs	p.K195fs	ZC3H13_uc001vas.1_Frame_Shift_Del_p.K195fs|ZC3H13_uc001vat.1_Frame_Shift_Del_p.K195fs	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	Homo sapiens zinc finger CCCH-type containing 13 (ZC3H13), mRNA.	195							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		AGCATACCTCCTTTTTAATGA	0.308												
CTSH	1512	broad.mit.edu	37	15	79215392	79215392	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr15:79215391_79215391AT>A	uc021srk.1	-	10	973	c.876_876AT>T	c.(874-876)aatfs	p.N292fs	CTSH_uc010unf.1_Non-coding_Transcript	NM_004390	NP_004381	P09668	CATH_HUMAN	Homo sapiens cathepsin H (CTSH), mRNA.	292					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)	10						AAGGGATCCCATTTTTTTCTC	0.473												
ABCC1	4363	broad.mit.edu	37	16	16142120	16142121	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:16142119_16142120G>GC	uc010bvi.3	+	9	1514_1515	c.1339_1340G>GC	c.(1339-1341)gccfs	p.A447fs	ABCC1_uc010bvj.3_Frame_Shift_Ins_p.A447fs|ABCC1_uc010bvk.3_Frame_Shift_Ins_p.A447fs|ABCC1_uc010bvl.3_Frame_Shift_Ins_p.A447fs|ABCC1_uc010bvm.3_Frame_Shift_Ins_p.A447fs|ABCC1_uc002del.4_Frame_Shift_Ins_p.A331fs|ABCC1_uc010bvn.3_Frame_Shift_Ins_p.A310fs	NM_004996	NP_004987	P33527	MRP1_HUMAN	Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ABCC1), transcript variant 1, mRNA.	447	ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GATCTGGTCAGCCCCCCTGCAA	0.545												
PLA2G15	23659	broad.mit.edu	37	16	68289855	68289855	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr16:68289854_68289854TG>T	uc002evr.3	+	4	771	c.688_688TG>T	c.(688-690)tggfs	p.W230fs	PLA2G15_uc010vld.2_Frame_Shift_Del_p.L188fs|PLA2G15_uc010vle.2_Frame_Shift_Del_p.W136fs|PLA2G15_uc010vlf.2_Intron|PLA2G15_uc002evs.3_Frame_Shift_Del_p.W51fs	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	Homo sapiens phospholipase A2, group XV (PLA2G15), mRNA.	230					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	12						GGGTGCGCCCTGGGGGGGCGT	0.632												
EFNB3	1949	broad.mit.edu	37	17	7612525	7612525	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:7612524_7612524GC>G	uc002gis.3	+	4	1050	c.653_653GC>G	c.(652-654)ggcfs	p.G218fs		NM_001406	NP_001397	Q15768	EFNB3_HUMAN	Homo sapiens ephrin-B3 (EFNB3), mRNA.	218					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				GGTGCTGAAGGCCCCCTGCCC	0.697												
STAT5B	6777	broad.mit.edu	37	17	40370236	40370237	+	Frame_Shift_Ins	INS	-	-	G	rs144993426		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:40370235_40370236T>TG	uc002hzh.3	-	8	1271_1272	c.1102_1103A>CA	c.(1102-1104)cagfs	p.Q368fs	STAT5B_uc002hzi.3_Frame_Shift_Ins_p.Q368fs	NM_012448	NP_036580	P51692	STA5B_HUMAN	Homo sapiens signal transducer and activator of transcription 5B (STAT5B), mRNA.	368					2-oxoglutarate metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GGCCTTCACCTGGGGGGGGTTC	0.574												
SEC14L1	6397	broad.mit.edu	37	17	75189591	75189591	+	Frame_Shift_Del	DEL	A	A	-	rs34381783		TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr17:75189590_75189590GA>G	uc010dhc.3	+	5	753	c.433_433GA>G	c.(433-435)gaafs	p.E145fs	SEC14L1_uc021udv.1_Frame_Shift_Del_p.E145fs|SEC14L1_uc021udw.1_Frame_Shift_Del_p.E145fs|SEC14L1_uc021udx.1_Frame_Shift_Del_p.E145fs|SEC14L1_uc002jto.3_Frame_Shift_Del_p.E145fs|SEC14L1_uc010wth.2_Frame_Shift_Del_p.E145fs|SEC14L1_uc002jtm.3_Frame_Shift_Del_p.E145fs|SEC14L1_uc010wti.2_Frame_Shift_Del_p.E111fs	NM_001039573	NP_001191337	Q92503	S14L1_HUMAN	Homo sapiens SEC14-like 1 (S. cerevisiae) (SEC14L1), transcript variant 2, mRNA.	145	PRELI/MSF1.				transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						AAGTACAGTGGAAAAAATTGC	0.378												
ZNF20	7568	broad.mit.edu	37	19	12243916	12243917	+	Frame_Shift_Ins	INS	-	-	GT			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:12243915_12243916A>AGT	uc002mtg.2	-	7	1667_1668	c.1085_1086T>ACT	c.(1084-1086)actfs	p.T362fs	ZNF20_uc002mte.2_Frame_Shift_Ins_p.T327fs|ZNF20_uc002mtf.2_Frame_Shift_Ins_p.T362fs|ZNF20_uc021upm.1_Frame_Shift_Ins_p.T359fs	NM_021143	NP_066966	P17024	ZNF20_HUMAN	Homo sapiens zinc finger protein 20 (ZNF20), transcript variant 1, mRNA.	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|lung(6)	8						GTTTATCCTCAGTGTGTGTCTT	0.455												
ZNF626	199777	broad.mit.edu	37	19	20808338	20808338	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:20808337_20808337CT>C	uc002npb.1	-	3	496	c.346_346AG>G	c.(346-348)ggafs	p.G116fs	ZNF626_uc002npc.1_Frame_Shift_Del_p.G40fs	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	Homo sapiens zinc finger protein 626 (ZNF626), transcript variant 1, mRNA.	116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						CTTATACATCCTTTTTTTAAC	0.348												
LMTK3	114783	broad.mit.edu	37	19	49000732	49000732	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:49000731_49000731TG>T	uc002pjk.3	-	11	3682	c.3682_3682CA>A	c.(3682-3684)aagfs	p.K1228fs		NM_001080434	NP_001073903			Homo sapiens lemur tyrosine kinase 3 (LMTK3), mRNA.											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTCTCGGGCTTGGGGGGGTCC	0.706												
ZIM3	114026	broad.mit.edu	37	19	57646555	57646556	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr19:57646554_57646555A>AT	uc002qnz.1	-	4	1536_1537	c.1150_1151T>AT	c.(1150-1152)atcfs	p.I384fs		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	Homo sapiens zinc finger, imprinted 3 (ZIM3), mRNA.	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K383Q(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCAGTATGGATTTTTTTATGT	0.391												
TP53RK	112858	broad.mit.edu	37	20	45315634	45315634	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:45315633_45315633AG>A	uc002xsk.3	-	1	744	c.521_521CT>T	c.(520-522)ctgfs	p.L174fs	SLC13A3_uc002xsg.2_5'Flank|SLC13A3_uc010gho.2_5'Flank|TP53RK_uc002xsj.3_3'UTR	NM_033550	NP_291028	Q96S44	PRPK_HUMAN	Homo sapiens TP53 regulating kinase (TP53RK), mRNA.	174	Protein kinase.				lipopolysaccharide biosynthetic process	membrane|nucleus	ATP binding|p53 binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.L174fs*23(2)		kidney(1)|large_intestine(1)|lung(4)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				CAGCTGTTCCAGGGGGGGTTT	0.493												
PMEPA1	56937	broad.mit.edu	37	20	56227349	56227350	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:56227348_56227349T>TG	uc002xyq.3	-	3	1017_1018	c.624_625A>CA	c.(622-627)cccagcfs	p.P208fs	PMEPA1_uc002xyr.3_Frame_Shift_Ins_p.P158fs|PMEPA1_uc002xys.3_Frame_Shift_Ins_p.P173fs|PMEPA1_uc002xyt.3_Frame_Shift_Ins_p.P158fs	NM_020182	NP_954640	Q969W9	PMEPA_HUMAN	Homo sapiens prostate transmembrane protein, androgen induced 1 (PMEPA1), transcript variant 1, mRNA.	208					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GAGTTACTGCTGGGGGGGCAGG	0.683												
SYCP2	10388	broad.mit.edu	37	20	58494655	58494655	+	Splice_Site	DEL	A	A	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chr20:58494654_58494654TA>T	uc002yaz.3	-	5	437	c.298_splice	c.e5-1	p.M100_splice	SYCP2_uc010gju.1_Splice_Site_p.M1_splice	NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	Homo sapiens synaptonemal complex protein 2 (SYCP2), mRNA.	100					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GGCAACCATGTAAAAAAAGGA	0.294												
SPIN3	169981	broad.mit.edu	37	X	57020676	57020676	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:57020675_57020675GT>G	uc022bxv.1	-	0	706	c.706_706AC>C	c.(706-708)cccfs	p.P236fs	SPIN3_uc004duu.4_Intron|SPIN3_uc004duw.4_Intron|SPIN3_uc004duv.4_Intron|SPIN3_uc010nkj.2_Frame_Shift_Del_p.P236fs|SPIN3_uc004dux.1_Frame_Shift_Del_p.P236fs	NM_001010862	NP_001010862	Q5JUX0	SPIN3_HUMAN	Homo sapiens spindlin family, member 3 (SPIN3), transcript variant 1, mRNA.	236					gamete generation					central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)	4						TACACAGAGGGTTTTGCTTCT	0.403												
BCORL1	63035	broad.mit.edu	37	X	129190011	129190011	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:129190010_129190010TC>T	uc022cdu.1	+	11	5079	c.5035_5035TC>T	c.(5035-5037)tccfs	p.S1679fs	BCORL1_uc004evc.2_Frame_Shift_Del_p.S515fs	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	Homo sapiens BCL6 corepressor-like 1 (BCORL1), mRNA.	1679					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GGACGACAGATCCCCCCCAGG	0.607												
GPR112	139378	broad.mit.edu	37	X	135488065	135488065	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6802-01A-11D-1882-08	TCGA-BR-6802-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d3725a6f-6ed6-4b8d-8d69-091058167abd	1f579d9f-6205-4095-a016-35ac9bd25f07	g.chrX:135488064_135488064AT>A	uc004ezu.1	+	22	9159	c.8868_8868AT>A	c.(8866-8868)gcafs	p.A2956fs	GPR112_uc010nsb.1_Frame_Shift_Del_p.A2751fs	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	Homo sapiens G protein-coupled receptor 112 (GPR112), mRNA.	2956					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GGGGGTTTGCATTTTTTGCTT	0.448