Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
ASAP3	55616	broad.mit.edu	37	1	23763702	23763702	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr1:23763702C>T	uc001bha.2	-	14	1387	c.1263G>A	c.(1261-1263)CCG>CCA	p.P421P	ASAP3_uc001bgy.1_5'Flank|ASAP3_uc001bgz.1_5'Flank|ASAP3_uc010odz.1_Silent_p.P290P|ASAP3_uc010oea.1_Silent_p.P412P|ASAP3_uc001bhb.2_5'UTR	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	421					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						TGAGGTCGTGCGGCTCCCCAT	0.701000												
COL9A2	1298	broad.mit.edu	37	1	40775783	40775783	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr1:40775783C>T	uc001cfh.1	-	15	862	c.792G>A	c.(790-792)CCG>CCA	p.P264P	COL9A2_uc001cfi.1_Silent_p.P83P	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	264	Triple-helical region 3 (COL3).				axon guidance|skeletal system development	collagen type IX				ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			AGAGGCTTACCGGTGGCCCAG	0.612000												
SMG5	23381	broad.mit.edu	37	1	156235937	156235937	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr1:156235937G>A	uc001foc.3	-	12	1639	c.1490C>T	c.(1489-1491)TCT>TTT	p.S497F	SMG5_uc009wrv.2_5'UTR	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	497					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					ACTCTTGTCAGAGCCACTGTC	0.532000												
SPTA1	6708	broad.mit.edu	37	1	158651377	158651377	+	Silent	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr1:158651377G>A	uc001fst.1	-	4	670	c.471C>T	c.(469-471)GCC>GCT	p.A157A		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	157					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GGAACTTCAGGGCCCGCAGCA	0.527000												
OBSCN	84033	broad.mit.edu	37	1	228479801	228479801	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr1:228479801C>T	uc009xez.1	+	39	10586	c.10542C>T	c.(10540-10542)GAC>GAT	p.D3514D	OBSCN_uc001hsn.2_Silent_p.D3514D|OBSCN_uc001hsq.1_Silent_p.D770D	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3514	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CCATGGCGGACGCCGGGGAGT	0.622000												
PGR	5241	broad.mit.edu	37	11	100999115	100999115	+	Silent	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr11:100999115G>A	uc001pgh.2	-	1	1430	c.687C>T	c.(685-687)TCC>TCT	p.S229S	PGR_uc001pgi.2_Silent_p.S229S|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	229	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CAGACTCCTCGGACTCAGAGC	0.721000												
HOXC11	3227	broad.mit.edu	37	12	54367430	54367430	+	Silent	SNP	C	C	T	rs139414813		TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr12:54367430C>T	uc001sem.2	+	1	521	c.405C>T	c.(403-405)GCC>GCT	p.A135A		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	135					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAACCCCCGCCGGCTTCTACT	0.657000			T	NUP98	AML							
GTSF1	121355	broad.mit.edu	37	12	54858935	54858935	+	Silent	SNP	A	A	G			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr12:54858935A>G	uc001sgb.2	-	3	119	c.33T>C	c.(31-33)CCT>CCC	p.P11P		NM_144594	NP_653195	Q8WW33	GTSF1_HUMAN	gametocyte specific factor 1	11							metal ion binding				0		Myeloproliferative disorder(1001;0.00452)				ATAGCTTCTCAGGGTCCAGGG	0.428000												
ATP2A2	488	broad.mit.edu	37	12	110783130	110783130	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr12:110783130C>A	uc001tqk.3	+	18	3247	c.2684C>A	c.(2683-2685)CCG>CAG	p.P895Q	ATP2A2_uc001tql.3_Missense_Mutation_p.P895Q|ATP2A2_uc010sxy.1_Missense_Mutation_p.P868Q|ATP2A2_uc001tqn.3_5'Flank|ATP2A2_uc009zvn.2_5'Flank	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	895	Lumenal (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						TCCCCATACCCGATGACAATG	0.473000												
DDX54	79039	broad.mit.edu	37	12	113603453	113603453	+	Missense_Mutation	SNP	C	C	T	rs58401684	byFrequency	TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr12:113603453C>T	uc001tup.2	-	14	1743	c.1715G>A	c.(1714-1716)CGG>CAG	p.R572Q	DDX54_uc001tuq.3_Missense_Mutation_p.R572Q	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	572					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						ACTCACCGCCCGGGAGCGGTA	0.468000												
FBXL3	26224	broad.mit.edu	37	13	77595766	77595766	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr13:77595766C>A	uc001vkd.2	-	2	601	c.230G>T	c.(229-231)AGA>ATA	p.R77I		NM_012158	NP_036290	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	77	F-box.				regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		TTCAAAACATCTCCACAAGTC	0.393000												
CEBPE	1053	broad.mit.edu	37	14	23587828	23587828	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr14:23587828G>A	uc001wiv.1	-	1	647	c.473C>T	c.(472-474)ACT>ATT	p.T158I		NM_001805	NP_001796	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein epsilon	158						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		TGCTGCCAGAGTTGGGGGCAG	0.682000												
FOXG1	2290	broad.mit.edu	37	14	29237757	29237757	+	Silent	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr14:29237757G>A	uc001wqe.2	+	1	1471	c.1272G>A	c.(1270-1272)CCG>CCA	p.P424P		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	424					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCCCGCACCCGTCAATGACTT	0.657000												
SIPA1L1	26037	broad.mit.edu	37	14	72055091	72055091	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr14:72055091C>T	uc001xms.2	+	2	850	c.502C>T	c.(502-504)CGC>TGC	p.R168C	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R168C|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R168C|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R168C	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	168					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AAAAGCTCTTCGCAGAATACG	0.468000												
DUOX1	53905	broad.mit.edu	37	15	45433241	45433241	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr15:45433241G>A	uc001zus.1	+	14	1884	c.1538G>A	c.(1537-1539)CGC>CAC	p.R513H	DUOX1_uc001zut.1_Missense_Mutation_p.R513H|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	513	Peroxidase-like; mediates peroxidase activity.|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		GATGGTGACCGCTACTGGTTT	0.617000												
ATP8B4	79895	broad.mit.edu	37	15	50189583	50189583	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr15:50189583C>T	uc001zxu.2	-	23	2745	c.2603G>A	c.(2602-2604)CGA>CAA	p.R868Q	ATP8B4_uc010ber.2_Missense_Mutation_p.R741Q|ATP8B4_uc010ufd.1_Missense_Mutation_p.R678Q|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Missense_Mutation_p.R166Q	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	868	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTTGCACATTCGGAAATAAGA	0.403000												
VPS13C	54832	broad.mit.edu	37	15	62237921	62237921	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr15:62237921G>A	uc002agz.2	-	45	5215	c.5141C>T	c.(5140-5142)TCT>TTT	p.S1714F	VPS13C_uc002aha.2_Missense_Mutation_p.S1671F|VPS13C_uc002ahb.1_Missense_Mutation_p.S1714F|VPS13C_uc002ahc.1_Missense_Mutation_p.S1671F	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1714					protein localization					ovary(2)	2						TACCAAAAGAGACATGAAGAA	0.323000												
IGDCC3	9543	broad.mit.edu	37	15	65621886	65621886	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr15:65621886G>A	uc002aos.2	-	13	2299	c.2047C>T	c.(2047-2049)CCC>TCC	p.P683S	IGDCC3_uc002aor.1_5'UTR	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	683	Cytoplasmic (Potential).									ovary(3)	3						TGGCTCCGGGGACCCTGTGGA	0.597000												
ISLR2	57611	broad.mit.edu	37	15	74425927	74425927	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr15:74425927G>A	uc002axd.2	+	4	1601	c.832G>A	c.(832-834)GGT>AGT	p.G278S	ISLR2_uc002axe.2_Missense_Mutation_p.G278S|ISLR2_uc010bjg.2_Missense_Mutation_p.G278S|ISLR2_uc010bjf.2_Missense_Mutation_p.G278S	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	278	Ig-like.|Extracellular (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						TCAGATCCCCGGTGGCACCGT	0.468000												
DNAJA2	10294	broad.mit.edu	37	16	47005450	47005450	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr16:47005450G>C	uc002eeo.2	-	3	315	c.173C>G	c.(172-174)TCA>TGA	p.S58*	DNAJA2_uc002eep.2_Translation_Start_Site	NM_005880	NP_005871	O60884	DNJA2_HUMAN	DnaJ subfamily A member 2	58	J.				positive regulation of cell proliferation|protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			lung(1)	1		all_cancers(37;0.00125)|all_lung(18;0.00338)|all_epithelial(9;0.00358)|Lung NSC(13;0.0309)|Breast(268;0.116)				CTCAGGATTTGATAGTACTTC	0.383000												
SPG7	6687	broad.mit.edu	37	16	89611154	89611154	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr16:89611154G>A	uc002fnj.2	+	10	1444	c.1423G>A	c.(1423-1425)GTC>ATC	p.V475I	SPG7_uc002fnk.1_RNA	NM_003119	NP_003110	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 isoform 1	475	Mitochondrial matrix (Potential).				cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GGACCGGCACGTCTTCATTGA	0.627000												
PELP1	27043	broad.mit.edu	37	17	4576196	4576196	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr17:4576196G>A	uc002fyi.3	-	16	2316	c.2090C>T	c.(2089-2091)TCG>TTG	p.S697L	PELP1_uc010vsf.1_Missense_Mutation_p.S550L	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	697	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						AGGGCGTGCCGAGGGCACAGG	0.677000												
TRIM16	10626	broad.mit.edu	37	17	15539380	15539380	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr17:15539380C>T	uc002gox.2	-	6	1376	c.819G>A	c.(817-819)GCG>GCA	p.A273A	TRIM16_uc002gor.1_Silent_p.A273A|TRIM16_uc002gow.2_Silent_p.A57A|TRIM16_uc002goy.2_Silent_p.A143A	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	273	Potential.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		TGCTGATGGCCGCCATCCTCT	0.607000												
DNAH17	8632	broad.mit.edu	37	17	76457765	76457765	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr17:76457765G>A	uc010dhp.1	-	3	422	c.200C>T	c.(199-201)GCG>GTG	p.A67V	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CTCCTGAATCGCCAACTTGGC	0.577000												
LAMA1	284217	broad.mit.edu	37	18	6974963	6974963	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr18:6974963G>A	uc002knm.2	-	46	6656	c.6562C>T	c.(6562-6564)CGC>TGC	p.R2188C	LAMA1_uc010wzj.1_Missense_Mutation_p.R1664C	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2188	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AACTCCAAGCGTGTGGACCCG	0.532000												
FBN3	84467	broad.mit.edu	37	19	8156417	8156417	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr19:8156417C>G	uc002mjf.2	-	47	5984	c.5963G>C	c.(5962-5964)AGC>ACC	p.S1988T	FBN3_uc002mje.2_5'Flank	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1988	EGF-like 32; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCTCCCAGGGCTGTTGGTACA	0.592000												
C19orf57	79173	broad.mit.edu	37	19	14000238	14000238	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr19:14000238C>T	uc002mxl.1	-	6	1490	c.1431G>A	c.(1429-1431)CCG>CCA	p.P477P	C19orf57_uc002mxk.1_Silent_p.P359P|C19orf57_uc002mxm.1_Intron	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	477					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			CAGAGGCTTGCGGGGACACAC	0.597000												
PTPRH	5794	broad.mit.edu	37	19	55697282	55697282	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr19:55697282A>G	uc002qjq.2	-	17	2922	c.2849T>C	c.(2848-2850)GTA>GCA	p.V950A	PTPRH_uc010esv.2_Missense_Mutation_p.V772A	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	950	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TTCCTCACCTACCAGGGTTAC	0.627000												
FIZ1	84922	broad.mit.edu	37	19	56108964	56108964	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr19:56108964C>T	uc002qli.3	-	2	358	c.268G>A	c.(268-270)GAC>AAC	p.D90N	FIZ1_uc002qlj.3_Missense_Mutation_p.D90N|ZNF524_uc002qlk.1_5'Flank	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	90	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CCGGTGGAGTCGCGGAACCCC	0.682000												
ZNF470	388566	broad.mit.edu	37	19	57088681	57088681	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr19:57088681A>G	uc002qnl.3	+	6	1560	c.884A>G	c.(883-885)CAG>CGG	p.Q295R	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	295	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		GCCTTCAGCCAGAATGCTCAT	0.448000												
LRP1B	53353	broad.mit.edu	37	2	141299517	141299517	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr2:141299517C>T	uc002tvj.1	-	44	8190	c.7218G>A	c.(7216-7218)GGG>GGA	p.G2406G		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2406	Extracellular (Potential).|LDL-receptor class B 26.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGAGGAAAGTCCCTGGCCCAG	0.363000										TSP Lung(27;0.18)		
NEB	4703	broad.mit.edu	37	2	152486101	152486101	+	Silent	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr2:152486101G>A	uc010fnx.2	-	64	9245	c.9054C>T	c.(9052-9054)GAC>GAT	p.D3018D	NEB_uc002txu.2_Silent_p.D365D	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3018	Nebulin 82.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGGGGATGGCGTCACTTCGCA	0.458000												
NR4A2	4929	broad.mit.edu	37	2	157186116	157186116	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr2:157186116C>T	uc002tyz.3	-	3	1005	c.583G>A	c.(583-585)GAC>AAC	p.D195N	NR4A2_uc002tyx.3_Missense_Mutation_p.D132N|NR4A2_uc010zcf.1_Missense_Mutation_p.D195N|NR4A2_uc010zcg.1_5'Flank	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	195	Pro-rich.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						AGGGGCCCGTCGAAGCGCATC	0.657000												
SERINC3	10955	broad.mit.edu	37	20	43135528	43135528	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr20:43135528G>C	uc002xme.2	-	6	857	c.723C>G	c.(721-723)ATC>ATG	p.I241M	SERINC3_uc002xmf.1_Missense_Mutation_p.I241M|SERINC3_uc010ggs.1_Missense_Mutation_p.I234M|SERINC3_uc010zwp.1_Missense_Mutation_p.I186M	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	241	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GGTTAATACTGATGAAGAACT	0.393000												
BCAS1	8537	broad.mit.edu	37	20	52645436	52645436	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr20:52645436G>T	uc002xws.2	-	4	556	c.218C>A	c.(217-219)GCG>GAG	p.A73E	BCAS1_uc010zzb.1_5'UTR|BCAS1_uc010gim.2_5'UTR|BCAS1_uc002xwt.2_Missense_Mutation_p.A73E|BCAS1_uc010gil.1_Missense_Mutation_p.A73E|BCAS1_uc010zzc.1_5'UTR	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	73						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			GTTGGCATCCGCAACAGCACT	0.493000												
ZNF831	128611	broad.mit.edu	37	20	57767259	57767259	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr20:57767259C>T	uc002yan.2	+	1	1185	c.1185C>T	c.(1183-1185)GCC>GCT	p.A395A		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	395	Potential.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					cgcgAGAAGCCGGCCTGGAGC	0.502000												
TRIOBP	11078	broad.mit.edu	37	22	38130723	38130723	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr22:38130723G>A	uc003atr.2	+	9	4651	c.4380G>A	c.(4378-4380)TGG>TGA	p.W1460*	TRIOBP_uc003atu.2_Nonsense_Mutation_p.W1288*	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1460					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GGGGCTGGTGGGGATGTGGAG	0.687000												
XRCC6	2547	broad.mit.edu	37	22	42033616	42033616	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr22:42033616C>T	uc003bao.1	+	6	664	c.594C>T	c.(592-594)ATC>ATT	p.I198I	XRCC6_uc003bap.1_Silent_p.I157I|XRCC6_uc011apc.1_Silent_p.I148I|XRCC6_uc003baq.1_Silent_p.I198I|XRCC6_uc003bar.1_Silent_p.I198I|XRCC6_uc003bas.1_Silent_p.I148I	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	198					DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						CAACAGGCATCTTCCTTGACT	0.418000								Direct_reversal_of_damage|NHEJ				
TRANK1	9881	broad.mit.edu	37	3	36869827	36869827	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr3:36869827T>A	uc003cgj.2	-	14	7369	c.7067A>T	c.(7066-7068)GAC>GTC	p.D2356V		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2906					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CTCACCAAAGTCTTCAACTTC	0.313000												
SCN10A	6336	broad.mit.edu	37	3	38739967	38739967	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr3:38739967G>A	uc003ciq.2	-	27	4744	c.4744C>T	c.(4744-4746)CGC>TGC	p.R1582C		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1582	IV.|Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CTGAGGATGCGGCCAATTCGG	0.517000												
KIAA1524	57650	broad.mit.edu	37	3	108273290	108273290	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr3:108273290C>T	uc003dxb.3	-	18	2526	c.2257G>A	c.(2257-2259)GAT>AAT	p.D753N		NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	753	Potential.					cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						TTCAGAGAATCACATGTGATC	0.303000												
C4orf44	345222	broad.mit.edu	37	4	3251150	3251150	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr4:3251150G>C	uc003ggs.2	+	1	384	c.201G>C	c.(199-201)CAG>CAC	p.Q67H	C4orf44_uc003ggt.2_Missense_Mutation_p.Q67H	NM_001042690	NP_001036155	Q6ZTZ1	CD044_HUMAN	hypothetical protein LOC345222 isoform a	67											0						AGCTCAAGCAGACCAAGCGCA	0.632000												
ADCY2	108	broad.mit.edu	37	5	7695884	7695884	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr5:7695884G>A	uc003jdz.1	+	6	956	c.889G>A	c.(889-891)GTT>ATT	p.V297I	ADCY2_uc011cmo.1_Missense_Mutation_p.V117I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	297	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CGCTGACATCGTTGGCTTTAC	0.408000												
CDC5L	988	broad.mit.edu	37	6	44392169	44392169	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr6:44392169G>A	uc003oxl.2	+	11	1677	c.1418G>A	c.(1417-1419)CGA>CAA	p.R473Q		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	473	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGAGAATCCCGAGAACATCTC	0.378000												
LANCL2	55915	broad.mit.edu	37	7	55492979	55492979	+	Silent	SNP	C	C	G			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr7:55492979C>G	uc003tqp.2	+	7	1619	c.1041C>G	c.(1039-1041)GCC>GCG	p.A347A		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	347					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TGAAAGAGGCCATGGAGTGTA	0.468000												
AKAP9	10142	broad.mit.edu	37	7	91682266	91682266	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr7:91682266C>T	uc003ulg.2	+	22	5820	c.5595C>T	c.(5593-5595)AGC>AGT	p.S1865S	AKAP9_uc003ulf.2_Silent_p.S1865S|AKAP9_uc003uli.2_Silent_p.S1488S	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1877	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GTGAAACTAGCAGTCAGGTAA	0.368000			T	BRAF	papillary thyroid							
C7orf33	202865	broad.mit.edu	37	7	148311189	148311189	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr7:148311189C>T	uc003wew.2	+	2	621	c.260C>T	c.(259-261)TCA>TTA	p.S87L		NM_145304	NP_660347	Q8WU49	CG033_HUMAN	hypothetical protein LOC202865	87										central_nervous_system(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GCTCCTGTATCAGCTCCCACC	0.493000												
GPR124	25960	broad.mit.edu	37	8	37691340	37691340	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr8:37691340C>T	uc003xkj.2	+	10	1794	c.1431C>T	c.(1429-1431)GTC>GTT	p.V477V	GPR124_uc010lvy.2_Silent_p.V477V	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	477	Extracellular (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TGGGTTATGTCGACCAGATCA	0.527000												
NBN	4683	broad.mit.edu	37	8	90965531	90965531	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr8:90965531C>T	uc003yej.1	-	11	1896	c.1786G>A	c.(1786-1788)GAT>AAT	p.D596N	NBN_uc003yei.1_Missense_Mutation_p.D514N|NBN_uc011lgb.1_Missense_Mutation_p.D596N	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	596					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			GTTTCTATATCCATCCTTGGC	0.338000								Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome			
TLN1	7094	broad.mit.edu	37	9	35714789	35714789	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr9:35714789C>T	uc003zxt.2	-	22	3193	c.2839G>A	c.(2839-2841)GGC>AGC	p.G947S		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	947					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GGCTGGGGGCCGGCAGAGGCC	0.587000												
ZNF658	26149	broad.mit.edu	37	9	40772474	40772474	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr9:40772474C>T	uc004abs.2	-	5	2953	c.2801G>A	c.(2800-2802)GGG>GAG	p.G934E	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.G934E	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GGGTTTCTCCCCCGTATGAAC	0.438000												
ZBTB43	23099	broad.mit.edu	37	9	129594921	129594921	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr9:129594921C>T	uc004bql.2	+	3	406	c.133C>T	c.(133-135)CGG>TGG	p.R45W	ZBTB43_uc010mxf.2_Missense_Mutation_p.R45W	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	45	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCACATTTTCCGGGCACACAA	0.473000												
HCFC1	3054	broad.mit.edu	37	X	153225353	153225353	+	Silent	SNP	C	C	T			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chrX:153225353C>T	uc004fjp.2	-	8	1872	c.1344G>A	c.(1342-1344)CTG>CTA	p.L448L		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	448					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCCTGGGGCAGGAGCGTGA	0.672000												
MUC6	4588	broad.mit.edu	37	11	1016198	1016200	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr11:1016198_1016200delAGA	uc001lsw.2	-	31	6652_6654	c.6601_6603delTCT	c.(6601-6603)TCTdel	p.S2201del		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2201	Ser-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGGCAGCTGGAGAAGAAGGAAAA	0.557												
GRID2	2895	broad.mit.edu	37	4	94344114	94344114	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr4:94344114delT	uc011cdt.1	+	10	1798	c.1540delT	c.(1540-1542)TTTfs	p.F514fs	GRID2_uc011cdu.1_Frame_Shift_Del_p.F419fs	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	514	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGAACTTGTCTTTAAGGTAAG	0.373												
ADH1C	126	broad.mit.edu	37	4	100268233	100268236	+	Frame_Shift_Del	DEL	AGGA	AGGA	-			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr4:100268233_100268236delAGGA	uc003huu.2	-	3	271_274	c.186_189delTCCT	c.(184-189)CTTCCTfs	p.L62fs		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	62_63					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CTAAAATCACAGGAAGGGGGGTCA	0.485									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of			
BCL9L	283149	broad.mit.edu	37	11	118770652	118770653	+	Frame_Shift_Ins	INS	-	-	G	rs139987150		TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr11:118770651_118770652T>TG	uc001pug.3	-	6	4345_4346	c.3380_3381A>CA	c.(3379-3381)ccafs	p.P1127fs	BCL9L_uc009zal.3_Frame_Shift_Ins_p.P1122fs	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	Homo sapiens B-cell CLL/lymphoma 9-like (BCL9L), mRNA.	1127	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GCGGTGGTGGTGGGGGGGGCAG	0.703												
MBD6	114785	broad.mit.edu	37	12	57921732	57921733	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-6801-01A-11D-1882-08	TCGA-BR-6801-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cee38c82-b415-4da9-adfe-664814ddbfd3	35f087a6-294f-42a2-a031-dc3109fe692d	g.chr12:57921731_57921732T>TG	uc001soj.1	+	8	2561_2562	c.2337_2338T>TG	c.(2335-2340)cctgggfs	p.P779fs	MBD6_uc001sok.1_Frame_Shift_Ins_p.P646fs|MBD6_uc001sol.1_Non-coding_Transcript	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	Homo sapiens methyl-CpG binding domain protein 6 (MBD6), mRNA.	779	Pro-rich.					chromosome|nucleus	DNA binding|chromatin binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						AGCTCCTCCCTGGGGGGGGAGC	0.629