Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PLOD1	5351	broad.mit.edu	37	1	12008083	12008083	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:12008083C>T	uc001atm.2	+	2	218	c.127C>T	c.(127-129)CGC>TGC	p.R43C	PLOD1_uc010obb.1_Missense_Mutation_p.R90C	NM_000302	NP_000293	Q02809	PLOD1_HUMAN	lysyl hydroxylase 1 precursor	43					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			ovary(2)|breast(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGGATTCCGTCGCTTCAAGCG	0.552000												
EPB41	2035	broad.mit.edu	37	1	29391555	29391555	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:29391555A>T	uc001brm.1	+	15	2076	c.2069A>T	c.(2068-2070)AAG>ATG	p.K690M	EPB41_uc001brg.1_Missense_Mutation_p.K467M|EPB41_uc001brh.1_Missense_Mutation_p.K448M|EPB41_uc001bri.1_Missense_Mutation_p.K601M|EPB41_uc001brj.1_Missense_Mutation_p.K427M|EPB41_uc001brk.2_Missense_Mutation_p.K676M|EPB41_uc001brl.1_Missense_Mutation_p.K657M|EPB41_uc009vtl.1_Missense_Mutation_p.K427M|EPB41_uc009vtm.1_Missense_Mutation_p.K269M	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	690	Spectrin--actin-binding.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		GAGCTGAAAAAGAACTTCATG	0.418000												
POU3F1	5453	broad.mit.edu	37	1	38511541	38511541	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:38511541G>T	uc001ccp.1	-	1	910	c.875C>A	c.(874-876)ACC>AAC	p.T292N		NM_002699	NP_002690	Q03052	PO3F1_HUMAN	POU domain, class 3, transcription factor 1	292	POU-specific.				positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GCGGCAGATGGTGGTCTGCGA	0.627000												
CHIA	27159	broad.mit.edu	37	1	111862929	111862929	+	Silent	SNP	G	G	T	rs35242709	byFrequency	TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:111862929G>T	uc001eas.2	+	12	1375	c.1272G>T	c.(1270-1272)TCG>TCT	p.S424S	CHIA_uc001ear.2_Silent_p.S316S|CHIA_uc001eaq.2_Silent_p.S316S|CHIA_uc009wgc.2_Silent_p.S316S|CHIA_uc001eat.2_Silent_p.S263S|CHIA_uc001eav.2_Silent_p.S263S|CHIA_uc001eau.2_Silent_p.S263S|CHIA_uc009wgd.2_Silent_p.S263S	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	424					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		GAGGCAGCTCGGGAGGCAGTG	0.592000												
CD1D	912	broad.mit.edu	37	1	158151974	158151974	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:158151974T>G	uc001frr.2	+	4	980	c.481T>G	c.(481-483)TTG>GTG	p.L161V	CD1D_uc009wsr.1_Missense_Mutation_p.L161V|CD1D_uc009wss.2_Missense_Mutation_p.L161V|CD1D_uc009wst.1_Missense_Mutation_p.L57V	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	161	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					TTGGGTAAACTTGGCCATTCA	0.493000												
OR10R2	343406	broad.mit.edu	37	1	158449804	158449804	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:158449804C>A	uc010pik.1	+	1	137	c.137C>A	c.(136-138)GCC>GAC	p.A46D	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					ATTCAGCTGGCCCTCTTTGTA	0.438000												
SPTA1	6708	broad.mit.edu	37	1	158646087	158646087	+	Splice_Site	SNP	T	T	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:158646087T>G	uc001fst.1	-	8	1157	c.958_splice	c.e8-1	p.V320_splice		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTCCTTCACCTTTGGGATGAA	0.423000												
USH2A	7399	broad.mit.edu	37	1	215901420	215901420	+	Silent	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:215901420G>A	uc001hku.1	-	61	12405	c.12018C>T	c.(12016-12018)CCC>CCT	p.P4006P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4006	Fibronectin type-III 25.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAGGATCGTCGGGTCTCTCCT	0.458000										HNSCC(13;0.011)		
FBXO28	23219	broad.mit.edu	37	1	224345314	224345314	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:224345314C>T	uc001hoh.2	+	5	1014	c.973C>T	c.(973-975)CGA>TGA	p.R325*	FBXO28_uc009xef.2_3'UTR|FBXO28_uc010pvc.1_Nonsense_Mutation_p.R120*	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	325										ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		ACGCAAACTACGAGAAGTAAT	0.488000												
OR2AK2	391191	broad.mit.edu	37	1	248129101	248129101	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:248129101C>A	uc010pzd.1	+	1	468	c.468C>A	c.(466-468)TGC>TGA	p.C156*	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			AGAAGATCTGCTGCCTCATGG	0.428000												
OR2M5	127059	broad.mit.edu	37	1	248308962	248308962	+	Silent	SNP	T	T	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr1:248308962T>C	uc010pze.1	+	1	513	c.513T>C	c.(511-513)TCT>TCC	p.S171S		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ACTGTGGGTCTCGGGAAATAG	0.438000												
CDH23	64072	broad.mit.edu	37	10	73544820	73544820	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr10:73544820C>T	uc001jrx.3	+	41	6052	c.5675C>T	c.(5674-5676)GCG>GTG	p.A1892V		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1892	Cadherin 18.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						AACATCACTGCGGGCAACCGC	0.602000												
FBXW4	6468	broad.mit.edu	37	10	103371080	103371080	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr10:103371080T>A	uc001kto.2	-	9	1553	c.1207A>T	c.(1207-1209)AAC>TAC	p.N403Y		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	403					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		ACGTGGAGGTTGTAAGACAGG	0.607000												
SORCS1	114815	broad.mit.edu	37	10	108389026	108389026	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr10:108389026G>A	uc001kym.2	-	19	2604	c.2596C>T	c.(2596-2598)CGT>TGT	p.R866C	SORCS1_uc001kyl.2_Missense_Mutation_p.R866C|SORCS1_uc009xxs.2_Missense_Mutation_p.R866C|SORCS1_uc001kyn.1_Missense_Mutation_p.R866C|SORCS1_uc001kyo.2_Missense_Mutation_p.R866C	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	866	Lumenal (Potential).|PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACGGTCACACGGAAAATGCCC	0.478000												
MRVI1	10335	broad.mit.edu	37	11	10622545	10622545	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr11:10622545G>A	uc010rcc.1	-	15	2323	c.1937C>T	c.(1936-1938)ACG>ATG	p.T646M	MRVI1_uc001miw.2_Missense_Mutation_p.T637M|MRVI1_uc010rcb.1_Missense_Mutation_p.T638M|MRVI1_uc009ygb.1_Missense_Mutation_p.T331M|MRVI1_uc001mix.2_Missense_Mutation_p.T331M|MRVI1_uc001miz.2_Missense_Mutation_p.T555M|MRVI1_uc009ygc.1_Missense_Mutation_p.T555M|MRVI1_uc010rcd.1_Missense_Mutation_p.T440M|MRVI1_uc009ygd.1_Missense_Mutation_p.T331M|MRVI1_uc010rce.1_RNA	NM_001100167	NP_001093637	Q9Y6F6	MRVI1_HUMAN	JAW1-related protein isoform c	619	Potential.				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				ovary(2)|central_nervous_system(1)	3				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTTCTCATACGTCCTCTTTAG	0.517000												
OR5T3	390154	broad.mit.edu	37	11	56020552	56020552	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr11:56020552A>T	uc010rjd.1	+	1	877	c.877A>T	c.(877-879)AGT>TGT	p.S293C		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	293	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TATGAGACCAAGTTCCAGCTA	0.398000												
MTL5	9633	broad.mit.edu	37	11	68475799	68475799	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr11:68475799A>G	uc001ooc.2	-	10	1644	c.1504T>C	c.(1504-1506)TCT>CCT	p.S502P		NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	502					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			AATCCCTTAGATTTAAACTCA	0.408000												
IGHMBP2	3508	broad.mit.edu	37	11	68673617	68673617	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr11:68673617G>A	uc001ook.1	+	2	269	c.167G>A	c.(166-168)CGC>CAC	p.R56H	IGHMBP2_uc001ooj.1_RNA|MRPL21_uc001ooh.2_5'Flank|MRPL21_uc001ooi.2_5'Flank|MRPL21_uc010rqe.1_5'Flank	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	56					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCCAGCCAGCGCACTGGGCTG	0.587000												
DLG2	1740	broad.mit.edu	37	11	84996402	84996402	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr11:84996402T>G	uc001pak.2	-	4	360	c.48A>C	c.(46-48)CAA>CAC	p.Q16H		NM_001142699	NP_001136171	Q15700	DLG2_HUMAN	chapsyn-110 isoform 1	Error:Variant_position_missing_in_Q15700_after_alignment						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CATAAAATTCTTGGATATCTG	0.323000												
TRPC6	7225	broad.mit.edu	37	11	101347160	101347160	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr11:101347160G>T	uc001pgk.3	-	6	2041	c.1616C>A	c.(1615-1617)GCA>GAA	p.A539E	TRPC6_uc009ywy.2_Missense_Mutation_p.A423E|TRPC6_uc009ywz.1_Missense_Mutation_p.A484E	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	539	Helical; (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		AATGAATGATGCTGCGAAAAT	0.408000												
HINFP	25988	broad.mit.edu	37	11	119004822	119004822	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr11:119004822C>T	uc001pvp.2	+	11	1357	c.1168C>T	c.(1168-1170)CGG>TGG	p.R390W	HINFP_uc001pvq.2_Missense_Mutation_p.R390W|HINFP_uc001pvr.2_Missense_Mutation_p.R143W	NM_015517	NP_056332	Q9BQA5	HINFP_HUMAN	MBD2 (methyl-CpG-binding protein)-interacting	390	Interaction with NPAT.|Required for activation of histone H4 transcription and contributes to DNA- binding.				DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						TGGCTATATGCGGCTGCAGCT	0.567000											OREG0021397	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
NLRX1	79671	broad.mit.edu	37	11	119052840	119052840	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr11:119052840G>A	uc001pvu.2	+	9	2607	c.2392G>A	c.(2392-2394)GTG>ATG	p.V798M	NLRX1_uc001pvv.2_Missense_Mutation_p.V798M|NLRX1_uc001pvw.2_Missense_Mutation_p.V798M|NLRX1_uc001pvx.2_Missense_Mutation_p.V798M	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	798	Required for the repression of MAVS- induced interferon signaling.|LRR 4.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		AGGTGTTGCCGTGCTAATGGA	0.637000												
FKBP4	2288	broad.mit.edu	37	12	2910480	2910480	+	Silent	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr12:2910480C>T	uc001qkz.2	+	9	1428	c.1230C>T	c.(1228-1230)CTC>CTT	p.L410L		NM_002014	NP_002005	Q02790	FKBP4_HUMAN	FK506 binding protein 52	410					negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging				0			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	AGAAGAAGCTCTATGCCAATA	0.562000												
KRAS	3845	broad.mit.edu	37	12	25378594	25378594	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr12:25378594C>G	uc001rgp.1	-	4	585	c.404G>C	c.(403-405)AGA>ACA	p.R135T	KRAS_uc001rgq.1_Missense_Mutation_p.R135T	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	135					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TCCATAACTTCTTGCTAAGTC	0.353000		119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)		
ANO4	121601	broad.mit.edu	37	12	101333096	101333096	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr12:101333096C>T	uc010svm.1	+	4	736	c.164C>T	c.(163-165)GCC>GTC	p.A55V	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.A20V|ANO4_uc001thx.2_Missense_Mutation_p.A55V	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	55	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GTTCTAGTGGCCAAGGATGTC	0.378000										HNSCC(74;0.22)		
MYO1H	283446	broad.mit.edu	37	12	109845697	109845697	+	Silent	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr12:109845697C>T	uc010sxn.1	+	9	1086	c.1086C>T	c.(1084-1086)ATC>ATT	p.I362I		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						TCAACAAAATCAATTCCTCCT	0.423000												
DGKH	160851	broad.mit.edu	37	13	42748255	42748255	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr13:42748255C>T	uc001uyl.1	+	12	1448	c.1427C>T	c.(1426-1428)CCT>CTT	p.P476L	DGKH_uc010tfh.1_Missense_Mutation_p.P476L|DGKH_uc001uym.1_Missense_Mutation_p.P476L|DGKH_uc010tfi.1_Missense_Mutation_p.P231L|DGKH_uc010tfj.1_Missense_Mutation_p.P331L|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.P331L|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	476					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		CTTCCAGGACCTCCAGAAGCA	0.363000												
STK24	8428	broad.mit.edu	37	13	99116043	99116043	+	Silent	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr13:99116043A>G	uc001vnm.1	-	7	1102	c.867T>C	c.(865-867)AAT>AAC	p.N289N	STK24_uc001vnn.1_Silent_p.N277N|STK24_uc010tim.1_Silent_p.N258N	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	289					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TTTTCTTTGCATTGCGTAGTA	0.473000												
AKAP6	9472	broad.mit.edu	37	14	33293356	33293356	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr14:33293356T>G	uc001wrq.2	+	13	6507	c.6337T>G	c.(6337-6339)TTA>GTA	p.L2113V		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	2113					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TTATTCGTACTTATCTCTCTC	0.473000												
GALNTL1	57452	broad.mit.edu	37	14	69787487	69787487	+	Silent	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr14:69787487G>A	uc010aqu.1	+	2	330	c.237G>A	c.(235-237)CTG>CTA	p.L79L	GALNTL1_uc001xla.1_Silent_p.L79L|GALNTL1_uc001xlb.1_Silent_p.L79L	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	79	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		CCAAGCAGCTGAAGGCTGGAG	0.592000												
VASH1	22846	broad.mit.edu	37	14	77242566	77242566	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr14:77242566G>A	uc001xst.2	+	5	1792	c.862G>A	c.(862-864)GAT>AAT	p.D288N		NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	288					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		CCTGGGCCGCGATGACTTCCG	0.552000												
AXIN1	8312	broad.mit.edu	37	16	354351	354351	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr16:354351G>A	uc002cgp.1	-	5	1384	c.1207C>T	c.(1207-1209)CGG>TGG	p.R403W	AXIN1_uc002cgq.1_Missense_Mutation_p.R403W	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	403	Interaction with GSK3B (By similarity).				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				TCGGCCTCCCGCGTGCGCTGC	0.687000												
MMP25	64386	broad.mit.edu	37	16	3100096	3100096	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr16:3100096C>T	uc002cth.2	+	3	556	c.319C>T	c.(319-321)CGG>TGG	p.R107W	MMP25_uc002cti.1_Missense_Mutation_p.R43W	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein	107	Poly-Arg.				inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						GCGGCGTCGCCGGTACGCTCT	0.701000												
ZNF200	7752	broad.mit.edu	37	16	3274181	3274181	+	Missense_Mutation	SNP	C	C	T	rs148762905		TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr16:3274181C>T	uc002cuj.2	-	5	1531	c.899G>A	c.(898-900)CGA>CAA	p.R300Q	ZNF200_uc002cum.3_Missense_Mutation_p.R299Q|ZNF200_uc010bti.2_Missense_Mutation_p.R299Q|ZNF200_uc002cuk.2_Missense_Mutation_p.R300Q|ZNF200_uc002cui.2_Missense_Mutation_p.R299Q|ZNF200_uc002cul.3_Missense_Mutation_p.R299Q	NM_003454	NP_003445	P98182	ZN200_HUMAN	zinc finger protein 200 isoform 1	300	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TGTATGAATTCGCTCATGTTT	0.418000												
TAOK2	9344	broad.mit.edu	37	16	29989217	29989217	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr16:29989217G>A	uc002dva.1	+	2	907	c.124G>A	c.(124-126)GTA>ATA	p.V42I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.V42I|TAOK2_uc002dvc.1_Missense_Mutation_p.V42I|TAOK2_uc010bzm.1_Missense_Mutation_p.V42I|TAOK2_uc002dvd.1_5'Flank	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	42	ATP (By similarity).|Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CTTTGGAGCCGTATACTTTGT	0.532000												
ITGAX	3687	broad.mit.edu	37	16	31371109	31371109	+	Silent	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr16:31371109C>T	uc002ebu.1	+	6	586	c.519C>T	c.(517-519)TTC>TTT	p.F173F	ITGAX_uc002ebt.2_Silent_p.F173F|ITGAX_uc010vfk.1_5'Flank	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	173	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGATGAACTTCGTGAGAGCTG	0.582000												
MYH2	4620	broad.mit.edu	37	17	10428212	10428212	+	Silent	SNP	G	G	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr17:10428212G>T	uc010coi.2	-	34	4961	c.4833C>A	c.(4831-4833)ATC>ATA	p.I1611I	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.I1611I|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1611	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCCTACTCCTGATCTCAGCAT	0.468000												
ITGA2B	3674	broad.mit.edu	37	17	42455111	42455111	+	Silent	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr17:42455111C>T	uc002igt.1	-	21	2174	c.2142G>A	c.(2140-2142)AGG>AGA	p.R714R	ITGA2B_uc002igu.1_Silent_p.R195R	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	714	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	ACAGCACCACCCTGGTCTCAT	0.498000												
B4GALNT2	124872	broad.mit.edu	37	17	47241497	47241497	+	Missense_Mutation	SNP	C	C	T	rs145043273		TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr17:47241497C>T	uc002ion.2	+	8	1053	c.994C>T	c.(994-996)CGC>TGC	p.R332C	B4GALNT2_uc010wlt.1_Missense_Mutation_p.R246C|B4GALNT2_uc010wlu.1_Missense_Mutation_p.R272C	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	332	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			GACTTTCCTCCGCCCCCACAA	0.502000												
MPO	4353	broad.mit.edu	37	17	56356886	56356886	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr17:56356886G>C	uc002ivu.1	-	4	723	c.546C>G	c.(544-546)AAC>AAG	p.N182K		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	182					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	AGCCGCACCTGTTGTTGCACA	0.652000												
MGAT5B	146664	broad.mit.edu	37	17	74928759	74928759	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr17:74928759G>A	uc002jti.2	+	10	1460	c.1357G>A	c.(1357-1359)GTG>ATG	p.V453M	MGAT5B_uc002jth.2_Missense_Mutation_p.V442M	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	442	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						CATGGGCTTCGTGTCCGAGGA	0.617000												
MC5R	4161	broad.mit.edu	37	18	13826438	13826438	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr18:13826438C>T	uc010xaf.1	+	1	674	c.674C>T	c.(673-675)GCC>GTC	p.A225V		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	225	Cytoplasmic (Potential).			ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						CTGCCCGGGGCCAGCTCTGCG	0.622000												
ZNF521	25925	broad.mit.edu	37	18	22805350	22805350	+	Silent	SNP	T	T	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr18:22805350T>G	uc002kvk.2	-	4	2779	c.2532A>C	c.(2530-2532)ACA>ACC	p.T844T	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.T844T|ZNF521_uc002kvl.2_Silent_p.T624T	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	844					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AAGCTCCATTTGTTCCACAGT	0.478000			T	PAX5	ALL							
PIK3C3	5289	broad.mit.edu	37	18	39618752	39618752	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr18:39618752G>A	uc002lap.2	+	18	2034	c.1976G>A	c.(1975-1977)CGG>CAG	p.R659Q	PIK3C3_uc010xcl.1_Missense_Mutation_p.R596Q|PIK3C3_uc002laq.2_Missense_Mutation_p.R144Q|PIK3C3_uc002lar.1_Missense_Mutation_p.R43Q	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	659	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						AAGCTGTTACGGAAAGAAAAT	0.289000										TSP Lung(28;0.18)		
ANKRD24	170961	broad.mit.edu	37	19	4219595	4219595	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:4219595G>A	uc010dtt.1	+	19	3287	c.3011G>A	c.(3010-3012)CGT>CAT	p.R1004H		NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1004	Potential.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		CAGGTGCAGCGTGAGGCCCTG	0.557000												
MUC16	94025	broad.mit.edu	37	19	9056390	9056390	+	Silent	SNP	A	A	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:9056390A>T	uc002mkp.2	-	3	31260	c.31056T>A	c.(31054-31056)ACT>ACA	p.T10352T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10354	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGAAGAGGAAGTTATCTCAT	0.498000												
MUC16	94025	broad.mit.edu	37	19	9064152	9064152	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:9064152G>A	uc002mkp.2	-	3	23498	c.23294C>T	c.(23293-23295)GCC>GTC	p.A7765V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7767	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGATGCACGGCTTCTGTATG	0.488000												
IL12RB1	3594	broad.mit.edu	37	19	18183067	18183067	+	Silent	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:18183067C>T	uc002nhw.1	-	9	940	c.876G>A	c.(874-876)CCG>CCA	p.P292P	IL12RB1_uc010xqb.1_Silent_p.P292P|IL12RB1_uc002nhx.1_Silent_p.P332P|IL12RB1_uc002nhy.2_Silent_p.P292P	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	292	Extracellular (Potential).|Fibronectin type-III 3.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						TGGCCTTACACGGGCAGGACA	0.607000												
COMP	1311	broad.mit.edu	37	19	18898331	18898331	+	Silent	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:18898331G>A	uc002nke.2	-	10	1140	c.1104C>T	c.(1102-1104)GGC>GGT	p.G368G	COMP_uc002nkd.2_Silent_p.G335G|COMP_uc010xqj.1_Silent_p.G315G	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	368	Cell attachment site (Potential).|TSP type-3 4.		Missing (in EDM1).		anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						CGCACGCATCGCCCCGGCCGT	0.687000												
TSHZ3	57616	broad.mit.edu	37	19	31767522	31767522	+	Silent	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:31767522G>A	uc002nsy.3	-	2	3242	c.3177C>T	c.(3175-3177)CAC>CAT	p.H1059H		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	1059	C2H2-type 5.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TTTTGCTAAGGTGAAGTTTAA	0.468000												
ZNF540	163255	broad.mit.edu	37	19	38103644	38103644	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:38103644T>G	uc002ogq.2	+	5	1795	c.1463T>G	c.(1462-1464)ATT>AGT	p.I488S	ZNF540_uc002ogu.2_Missense_Mutation_p.I488S|ZNF540_uc010efq.2_Missense_Mutation_p.I456S	NM_152606	NP_689819	Q8NDQ6	ZN540_HUMAN	zinc finger protein 540	488	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CATAAGAAAATTCATACTGAT	0.403000												
ZNF543	125919	broad.mit.edu	37	19	57839487	57839487	+	Silent	SNP	G	G	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:57839487G>C	uc002qoi.1	+	4	1002	c.657G>C	c.(655-657)CGG>CGC	p.R219R		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	219	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGCATGAACGGATTCACACTC	0.443000												
ZNF256	10172	broad.mit.edu	37	19	58452476	58452476	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:58452476C>G	uc002qqu.2	-	3	1935	c.1700G>C	c.(1699-1701)AGA>ACA	p.R567T	ZNF256_uc010euj.2_Missense_Mutation_p.R414T	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	567	C2H2-type 13.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GGTATGAACTCTTCGGTGTTT	0.453000												
SLC27A5	10998	broad.mit.edu	37	19	59010878	59010878	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr19:59010878G>A	uc002qtc.2	-	7	1758	c.1648C>T	c.(1648-1650)CGC>TGC	p.R550C	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	550	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		TCCCCGAGGCGGTCGCGGAAG	0.657000												
APOB	338	broad.mit.edu	37	2	21265256	21265256	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr2:21265256T>G	uc002red.2	-	3	342	c.214A>C	c.(214-216)AGT>CGT	p.S72R		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	72	Vitellogenin.|Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGTGGCACTTCTTGAATCA	0.572000												
PREPL	9581	broad.mit.edu	37	2	44566387	44566387	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr2:44566387C>T	uc002ruf.2	-	6	903	c.868G>A	c.(868-870)GTA>ATA	p.V290I	PREPL_uc002rug.2_Missense_Mutation_p.V290I|PREPL_uc002ruh.2_Missense_Mutation_p.V290I|PREPL_uc010fax.2_Missense_Mutation_p.V290I|PREPL_uc002rui.3_Missense_Mutation_p.V201I|PREPL_uc002ruj.1_Missense_Mutation_p.V201I|PREPL_uc002ruk.1_Missense_Mutation_p.V290I	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	290					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGGATAAGTACTGGTGGGTCC	0.388000												
TSPYL6	388951	broad.mit.edu	37	2	54482198	54482198	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr2:54482198C>G	uc002rxr.2	-	1	1212	c.1091G>C	c.(1090-1092)AGG>ACG	p.R364T	ACYP2_uc002rxq.3_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	TSPY-like 6	364					nucleosome assembly	nucleus					0						CTGAGCAATCCTGTCGGACTC	0.532000												
RAB11FIP5	26056	broad.mit.edu	37	2	73316188	73316188	+	Silent	SNP	G	G	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr2:73316188G>C	uc002siu.3	-	2	928	c.687C>G	c.(685-687)GGC>GGG	p.G229G	RAB11FIP5_uc002sit.3_Silent_p.G151G	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	229					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CTTTGGCTTTGCCCATCTTGC	0.592000												
GPD2	2820	broad.mit.edu	37	2	157407168	157407168	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr2:157407168C>T	uc002tzf.3	+	8	1241	c.881C>T	c.(880-882)ACG>ATG	p.T294M	GPD2_uc010zch.1_Missense_Mutation_p.T67M|GPD2_uc002tzd.3_Missense_Mutation_p.T294M|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	294					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						GGACCTTTCACGGACTCTGTG	0.463000												
TTN	7273	broad.mit.edu	37	2	179610671	179610671	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr2:179610671T>C	uc002unb.2	-	46	16680	c.16456A>G	c.(16456-16458)ACT>GCT	p.T5486A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCTTAAAGTCACTTTGCTT	0.423000												
ERBB4	2066	broad.mit.edu	37	2	213403244	213403244	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr2:213403244G>T	uc002veg.1	-	1	109	c.11C>A	c.(10-12)GCG>GAG	p.A4E	ERBB4_uc002veh.1_Missense_Mutation_p.A4E|ERBB4_uc010zji.1_Missense_Mutation_p.A4E|ERBB4_uc010zjj.1_Missense_Mutation_p.A4E|ERBB4_uc010fut.1_Missense_Mutation_p.A4E	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	4					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		AAGTCCTGTCGCCGGCTTCAT	0.582000										TSP Lung(8;0.080)		
RASSF2	9770	broad.mit.edu	37	20	4771182	4771182	+	Missense_Mutation	SNP	C	C	T	rs145831009	byFrequency	TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr20:4771182C>T	uc002wld.2	-	6	506	c.452G>A	c.(451-453)CGC>CAC	p.R151H	RASSF2_uc002wlc.2_RNA|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.R151H	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	151					cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						ATTGCCACGGCGACGCACCCC	0.592000												
ACSS1	84532	broad.mit.edu	37	20	25004206	25004206	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr20:25004206C>T	uc002wub.2	-	4	1581	c.703G>A	c.(703-705)GTG>ATG	p.V235M	ACSS1_uc002wuc.2_Missense_Mutation_p.V235M|ACSS1_uc010gdc.2_Intron|ACSS1_uc002wud.1_5'Flank|ACSS1_uc002wua.2_Missense_Mutation_p.V152M	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	235					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCCTCATCCACTATTTTCTTC	0.557000												
PKIG	11142	broad.mit.edu	37	20	43243200	43243200	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr20:43243200G>A	uc002xmg.2	+	5	532	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PKIG_uc002xmh.2_Missense_Mutation_p.M1I|PKIG_uc002xmi.2_Missense_Mutation_p.M1I	NM_181805	NP_861521	Q9Y2B9	IPKG_HUMAN	cAMP-dependent protein kinase inhibitor gamma	1							cAMP-dependent protein kinase inhibitor activity|protein binding				0		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.001)|COAD - Colon adenocarcinoma(18;0.00189)			CGACAGGCATGATGGAGGTCG	0.607000												
KRTAP13-3	337960	broad.mit.edu	37	21	31797958	31797958	+	Silent	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr21:31797958A>G	uc002yob.1	-	1	273	c.273T>C	c.(271-273)TCT>TCC	p.S91S		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	91	5 X 10 AA approximate repeats.					intermediate filament				ovary(1)|lung(1)	2						TAGTCAGGCAAGAATTGCAGA	0.567000												
ETS2	2114	broad.mit.edu	37	21	40186841	40186841	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr21:40186841T>A	uc002yxg.2	+	5	637	c.441T>A	c.(439-441)TTT>TTA	p.F147L	ETS2_uc002yxf.2_Missense_Mutation_p.F287L	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	147	PNT.				positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				AGGAACGCTTTCTGGAGCTGG	0.512000												
GAB4	128954	broad.mit.edu	37	22	17472913	17472913	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr22:17472913A>C	uc002zlw.2	-	2	436	c.328T>G	c.(328-330)TTC>GTC	p.F110V	GAB4_uc010gqs.1_Missense_Mutation_p.F110V	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	110	PH.									large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TTCTTGTTGAAGTTCAGAGTC	0.478000												
PLA2G3	50487	broad.mit.edu	37	22	31533854	31533854	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr22:31533854C>T	uc003aka.2	-	4	1037	c.908G>A	c.(907-909)CGA>CAA	p.R303Q		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	phospholipase A2, group III precursor	303					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity				0						CTGCTTCTGTCGAGGCTTGGG	0.657000												
TRIOBP	11078	broad.mit.edu	37	22	38120424	38120424	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr22:38120424C>T	uc003atr.2	+	7	2132	c.1861C>T	c.(1861-1863)CGA>TGA	p.R621*	TRIOBP_uc003atu.2_Nonsense_Mutation_p.R449*|TRIOBP_uc003atq.1_Nonsense_Mutation_p.R621*|TRIOBP_uc003ats.1_Nonsense_Mutation_p.R449*	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	621					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TAGAGCCACACGAGATAACCC	0.582000												
IL17RE	132014	broad.mit.edu	37	3	9952952	9952952	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:9952952A>G	uc003btu.2	+	12	1157	c.1040A>G	c.(1039-1041)AAC>AGC	p.N347S	CIDEC_uc003bto.2_Intron|IL17RE_uc011atn.1_RNA|IL17RE_uc003btw.2_Missense_Mutation_p.N347S|IL17RE_uc003btx.2_Missense_Mutation_p.N231S|IL17RE_uc010hcq.2_Missense_Mutation_p.N347S|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	347	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		TCTTTTGGAAACAGCAGCCAT	0.493000												
RFTN1	23180	broad.mit.edu	37	3	16419336	16419336	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:16419336A>G	uc003cay.2	-	5	997	c.715T>C	c.(715-717)TCA>CCA	p.S239P	RFTN1_uc010hes.2_Missense_Mutation_p.S203P	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	239						plasma membrane				ovary(3)|central_nervous_system(1)	4						CCGGAGGGTGAGCTGGGCTGC	0.642000												
SCN5A	6331	broad.mit.edu	37	3	38591857	38591857	+	Silent	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:38591857G>A	uc003cio.2	-	28	6200	c.6006C>T	c.(6004-6006)GCC>GCT	p.A2002A	SCN5A_uc003cin.2_Silent_p.A2001A|SCN5A_uc003cil.3_Silent_p.A2002A|SCN5A_uc010hhi.2_Silent_p.A1984A|SCN5A_uc010hhk.2_Silent_p.A1969A|SCN5A_uc011ayr.1_Silent_p.A1948A	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	2002					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGGGGAAGTCGGCGAGATCTT	0.592000												
LRIG1	26018	broad.mit.edu	37	3	66430710	66430710	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:66430710G>C	uc003dmx.2	-	19	3273	c.3259C>G	c.(3259-3261)CTG>GTG	p.L1087V	SLC25A26_uc011bft.1_RNA|LRIG1_uc011bfu.1_Missense_Mutation_p.L707V|LRIG1_uc003dmw.2_Missense_Mutation_p.L753V|LRIG1_uc010hnz.2_Missense_Mutation_p.L803V|LRIG1_uc010hoa.2_Missense_Mutation_p.L1064V	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	1087	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCCAACAGCAGTGGCACCCTC	0.547000												
TMPRSS7	344805	broad.mit.edu	37	3	111799889	111799889	+	Silent	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:111799889C>T	uc010hqb.2	+	16	2282	c.2112C>T	c.(2110-2112)AAC>AAT	p.N704N	TMPRSS7_uc011bhr.1_Silent_p.N559N	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	830	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						GGGTGTCAAACTTTGTTCCCT	0.353000												
GOLGB1	2804	broad.mit.edu	37	3	121448138	121448138	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:121448138G>A	uc003eei.3	-	4	425	c.299C>T	c.(298-300)GCG>GTG	p.A100V	GOLGB1_uc010hrc.2_Missense_Mutation_p.A100V|GOLGB1_uc003eej.3_Missense_Mutation_p.A61V|GOLGB1_uc011bjm.1_Missense_Mutation_p.A61V|GOLGB1_uc010hrd.1_Missense_Mutation_p.A100V	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	100	Potential.|Cytoplasmic (Potential).				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTTGGCCTTCGCATGAAGTTT	0.363000												
EPHB1	2047	broad.mit.edu	37	3	134920329	134920329	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:134920329A>T	uc003eqt.2	+	12	2364	c.2144A>T	c.(2143-2145)CAG>CTG	p.Q715L	EPHB1_uc003equ.2_Missense_Mutation_p.Q276L	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	715	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						AATGACGGGCAGTTCACCGTG	0.527000												
PLSCR5	389158	broad.mit.edu	37	3	146311762	146311762	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:146311762G>C	uc003ewb.2	-	4	1402	c.398C>G	c.(397-399)ACA>AGA	p.T133R	PLSCR5_uc010hvb.2_Missense_Mutation_p.T121R|PLSCR5_uc010hvc.2_Missense_Mutation_p.T133R	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	133											0						CCTGTTCACTGTAATGACCTC	0.463000												
NMD3	51068	broad.mit.edu	37	3	160945104	160945104	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:160945104G>C	uc003feb.1	+	4	368	c.249G>C	c.(247-249)TTG>TTC	p.L83F	NMD3_uc003fec.2_Missense_Mutation_p.L83F|NMD3_uc003fed.1_Missense_Mutation_p.L83F	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	83					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			CTTTGTGCTTGAAAAAAATCA	0.343000												
WDR49	151790	broad.mit.edu	37	3	167254760	167254760	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:167254760A>G	uc003fev.1	-	7	1102	c.796T>C	c.(796-798)TTC>CTC	p.F266L	WDR49_uc003feu.1_Missense_Mutation_p.F91L|WDR49_uc011bpd.1_Missense_Mutation_p.F330L|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	266										large_intestine(1)|ovary(1)|skin(1)	3						AATTGATTGAAGTTTTGGGGT	0.393000												
LPP	4026	broad.mit.edu	37	3	188327328	188327328	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:188327328G>C	uc003frs.1	+	6	1055	c.809G>C	c.(808-810)GGC>GCC	p.G270A	LPP_uc011bsg.1_Intron|LPP_uc011bsi.1_Missense_Mutation_p.G270A|LPP_uc003frt.2_Missense_Mutation_p.G270A|LPP_uc011bsj.1_Missense_Mutation_p.G107A	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	270	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		ACACGGGGAGGCATGGATTAT	0.557000			T	HMGA2|MLL|C12orf9	lipoma|leukemia							
ATP13A5	344905	broad.mit.edu	37	3	193007764	193007764	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr3:193007764A>T	uc011bsq.1	-	26	2933	c.2933T>A	c.(2932-2934)TTT>TAT	p.F978Y		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	978	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		GGAATTCAAAAATATTGAAAG	0.433000												
ZNF518B	85460	broad.mit.edu	37	4	10445492	10445492	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr4:10445492A>C	uc003gmn.2	-	3	2948	c.2461T>G	c.(2461-2463)TCA>GCA	p.S821A		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	821					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						TGTAAGTCTGAGTCCGCCTGT	0.468000												
CWH43	80157	broad.mit.edu	37	4	49005981	49005981	+	Silent	SNP	C	C	T	rs151323921		TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr4:49005981C>T	uc003gyv.2	+	7	1214	c.1032C>T	c.(1030-1032)TAC>TAT	p.Y344Y	CWH43_uc011bzl.1_Silent_p.Y317Y	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	344					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						GAGGTGTCTACGCTAGAGAAA	0.393000												
LPHN3	23284	broad.mit.edu	37	4	62903555	62903555	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr4:62903555G>A	uc010ihh.2	+	21	3667	c.3494G>A	c.(3493-3495)CGC>CAC	p.R1165H	LPHN3_uc003hcq.3_Missense_Mutation_p.R1165H|LPHN3_uc003hct.2_Missense_Mutation_p.R549H	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1143	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ACTCCTGGACGCTACTCCACA	0.413000												
CXCL9	4283	broad.mit.edu	37	4	76924788	76924788	+	Missense_Mutation	SNP	C	C	T	rs139830877		TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr4:76924788C>T	uc003hjh.1	-	4	380	c.341G>A	c.(340-342)CGA>CAA	p.R114Q		NM_002416	NP_002407	Q07325	CXCL9_HUMAN	small inducible cytokine B9 precursor	114					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTGAGATTTTCGAACTTTCAG	0.338000												
IRX1	79192	broad.mit.edu	37	5	3599410	3599410	+	Silent	SNP	T	T	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:3599410T>C	uc003jde.2	+	2	400	c.348T>C	c.(346-348)GCT>GCC	p.A116A		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	116						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CGGCGCCGGCTTATTACCCCT	0.652000												
FBXL7	23194	broad.mit.edu	37	5	15928114	15928114	+	Silent	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:15928114C>T	uc003jfn.1	+	3	724	c.243C>T	c.(241-243)ACC>ACT	p.T81T		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	81					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CCTCCATCACCGGGGAGACGG	0.657000												
SLC45A2	51151	broad.mit.edu	37	5	33951726	33951726	+	Silent	SNP	G	G	A	rs148156477		TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:33951726G>A	uc003jid.2	-	5	1181	c.1089C>T	c.(1087-1089)TAC>TAT	p.Y363Y	SLC45A2_uc003jie.2_Silent_p.Y363Y|SLC45A2_uc003jif.3_3'UTR|SLC45A2_uc011coe.1_3'UTR	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	363	Extracellular (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CTCCTCTTTCGTAGATGAGAA	0.453000												
C5orf33	133686	broad.mit.edu	37	5	36226645	36226645	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:36226645C>T	uc003jkf.3	-	3	410	c.410G>A	c.(409-411)CGT>CAT	p.R137H	C5orf33_uc010iux.2_5'Flank|C5orf33_uc003jkg.3_5'UTR|C5orf33_uc011cov.1_5'UTR	NM_001085411	NP_001078880	Q4G0N4	NAKD1_HUMAN	hypothetical protein LOC133686 isoform 1	137							NAD+ kinase activity				0	all_lung(31;5.63e-05)		Epithelial(62;0.0254)|all cancers(62;0.0805)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTTTACTAGACGAACCTCAAT	0.378000												
ELOVL7	79993	broad.mit.edu	37	5	60050537	60050537	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:60050537G>T	uc003jsi.3	-	9	960	c.760C>A	c.(760-762)CTC>ATC	p.L254I	ELOVL7_uc011cqo.1_Missense_Mutation_p.L167I|ELOVL7_uc010iwk.2_Missense_Mutation_p.L254I|ELOVL7_uc003jsj.3_Missense_Mutation_p.L241I	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	254	Helical; (Potential).				fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				CAAAAATGGAGAAAGAGCAGC	0.398000												
MAST4	375449	broad.mit.edu	37	5	66459277	66459277	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:66459277G>A	uc003jut.1	+	28	3771	c.3703G>A	c.(3703-3705)GTC>ATC	p.V1235I	MAST4_uc003juw.2_Missense_Mutation_p.V1163I|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1427						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		GCCCACCATCGTCAGACACAT	0.637000												
CMYA5	202333	broad.mit.edu	37	5	79034738	79034738	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:79034738T>A	uc003kgc.2	+	2	10222	c.10150T>A	c.(10150-10152)TTT>ATT	p.F3384I		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3384						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GGAGGAAGAATTTGCATCTGG	0.488000												
CEP120	153241	broad.mit.edu	37	5	122724246	122724246	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:122724246G>C	uc003ktk.2	-	10	1392	c.1310C>G	c.(1309-1311)TCA>TGA	p.S437*	CEP120_uc011cwq.1_Nonsense_Mutation_p.S246*|CEP120_uc010jcz.1_Nonsense_Mutation_p.S411*	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	437						centrosome				ovary(1)	1						AGCTACTTCTGAAGCATTGGA	0.388000												
SLC36A2	153201	broad.mit.edu	37	5	150723122	150723122	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:150723122G>A	uc003lty.2	-	3	423	c.293C>T	c.(292-294)GCC>GTC	p.A98V	GM2A_uc011dcs.1_Intron|SLC36A2_uc003ltz.2_RNA|SLC36A2_uc003lua.2_5'UTR|SLC36A2_uc010jhv.2_Missense_Mutation_p.A98V|SLC36A2_uc011dct.1_Missense_Mutation_p.A98V	NM_181776	NP_861441	Q495M3	S36A2_HUMAN	solute carrier family 36, member 2	98	Helical; (Potential).				cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACAGTGGCAGGCAATGAAGCC	0.527000												
CYFIP2	26999	broad.mit.edu	37	5	156810315	156810315	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr5:156810315A>C	uc003lwq.2	+	30	3293	c.3155A>C	c.(3154-3156)AAG>ACG	p.K1052T	CYFIP2_uc011ddn.1_Missense_Mutation_p.K1026T|CYFIP2_uc011ddo.1_Missense_Mutation_p.K856T|CYFIP2_uc003lwr.2_Missense_Mutation_p.K1052T|CYFIP2_uc003lws.2_Missense_Mutation_p.K1052T|CYFIP2_uc003lwt.2_Missense_Mutation_p.K955T|CYFIP2_uc011ddp.1_Missense_Mutation_p.K786T|CYFIP2_uc003lwv.2_Missense_Mutation_p.K7T	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1077					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGGAAGCCAAGTATGCCCCG	0.522000												
HIST1H2AE	3012	broad.mit.edu	37	6	26217233	26217233	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr6:26217233G>A	uc003nha.1	+	1	86	c.31G>A	c.(31-33)GCT>ACT	p.A11T	HIST1H2BG_uc003ngz.2_5'Flank	NM_021052	NP_066390	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	11					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2		all_hematologic(11;0.196)				AGGCGGCAAAGCTCGGGCAAA	0.517000												
GPR110	266977	broad.mit.edu	37	6	46979887	46979887	+	Silent	SNP	T	T	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr6:46979887T>C	uc003oyt.2	-	10	1171	c.972A>G	c.(970-972)TCA>TCG	p.S324S	GPR110_uc011dwl.1_Silent_p.S12S	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	324	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						GCACGAAGGATGACACAGCTG	0.423000												
GFRAL	389400	broad.mit.edu	37	6	55223692	55223692	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr6:55223692C>G	uc003pcm.1	+	6	794	c.708C>G	c.(706-708)CAC>CAG	p.H236Q		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	236	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTAGGAGGCACTATAGAACAT	0.383000												
ROS1	6098	broad.mit.edu	37	6	117642553	117642553	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr6:117642553C>T	uc003pxp.1	-	35	5845	c.5646G>A	c.(5644-5646)TGG>TGA	p.W1882*	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Nonsense_Mutation_p.W194*	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1882	Helical; (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ATCTTCTATGCCAGACTATAA	0.363000			T	GOPC|ROS1	glioblastoma|NSCLC							
DNAH11	8701	broad.mit.edu	37	7	21847621	21847621	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr7:21847621G>T	uc003svc.2	+	64	10338	c.10307G>T	c.(10306-10308)CGC>CTC	p.R3436L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3436					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGGCAGTATCGCCAGGAGCTG	0.468000									Kartagener_syndrome			
GTF2IRD1	9569	broad.mit.edu	37	7	74005258	74005258	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr7:74005258C>T	uc003uaq.2	+	24	2941	c.2548C>T	c.(2548-2550)CGG>TGG	p.R850W	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.R867W|GTF2IRD1_uc003uap.2_Missense_Mutation_p.R835W|GTF2IRD1_uc003uar.1_Missense_Mutation_p.R835W	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	850	GTF2I-like 5.					nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						CATCCCCTTCCGGAACCCCAA	0.617000												
CLDN12	9069	broad.mit.edu	37	7	90042682	90042682	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr7:90042682C>T	uc003ukp.2	+	5	1328	c.692C>T	c.(691-693)TCT>TTT	p.S231F	CLDN12_uc003ukq.2_Missense_Mutation_p.S231F|CLDN12_uc010leq.2_Missense_Mutation_p.S231F|CLDN12_uc003ukr.2_Missense_Mutation_p.S231F|CLDN12_uc003uks.2_Missense_Mutation_p.S231F	NM_012129	NP_036261	P56749	CLD12_HUMAN	claudin 12	231	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TCTCGCCTCTCTGCCATTGAA	0.438000												
TAS2R16	50833	broad.mit.edu	37	7	122634836	122634836	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr7:122634836T>C	uc003vkl.1	-	1	919	c.853A>G	c.(853-855)AGG>GGG	p.R285G		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	285	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						TTTAGAATCCTTTTCAACGTA	0.418000												
POT1	25913	broad.mit.edu	37	7	124532403	124532403	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr7:124532403A>G	uc003vlm.2	-	6	642	c.41T>C	c.(40-42)CTG>CCG	p.L14P	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_5'UTR|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	14					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						AAGTTGATTCAGGGGTGTATA	0.333000												
GRM8	2918	broad.mit.edu	37	7	126173574	126173574	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr7:126173574A>G	uc003vlr.2	-	8	2173	c.1862T>C	c.(1861-1863)CTT>CCT	p.L621P	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.L621P|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	621	Helical; Name=2; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CACGTAACTAAGTTCGCGTCC	0.453000										HNSCC(24;0.065)		
CNTNAP2	26047	broad.mit.edu	37	7	146997238	146997238	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr7:146997238G>A	uc003weu.1	+	9	1870	c.1354G>A	c.(1354-1356)GGG>AGG	p.G452R		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	452	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACCAGGTTCTGGGTTGAATGA	0.373000										HNSCC(39;0.1)		
UBE3C	9690	broad.mit.edu	37	7	157046671	157046671	+	Silent	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr7:157046671G>A	uc010lqs.2	+	20	3030	c.2718G>A	c.(2716-2718)GGG>GGA	p.G906G	UBE3C_uc003wni.3_Silent_p.G269G	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	906	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(2)|large_intestine(1)	5		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		AATTCGGTGGGAAAGACATCC	0.453000												
ADCY8	114	broad.mit.edu	37	8	131916210	131916210	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr8:131916210C>A	uc003ytd.3	-	7	1975	c.1719G>T	c.(1717-1719)AGG>AGT	p.R573S	ADCY8_uc010mds.2_Missense_Mutation_p.R573S	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	573	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GGAATTCATTCCTCTCTTTAC	0.463000										HNSCC(32;0.087)		
PSIP1	11168	broad.mit.edu	37	9	15468792	15468792	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr9:15468792A>C	uc003zlv.3	-	14	1586	c.1256T>G	c.(1255-1257)TTG>TGG	p.L419W	PSIP1_uc003zlw.3_Missense_Mutation_p.L419W	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	419					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		CTTGTTATACAACATTGTAGA	0.343000												
TAF1L	138474	broad.mit.edu	37	9	32632187	32632187	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr9:32632187T>C	uc003zrg.1	-	1	3481	c.3391A>G	c.(3391-3393)AAA>GAA	p.K1131E	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1131					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GAGCTGGTTTTCTTGTTCTGC	0.468000												
FLJ46321	389763	broad.mit.edu	37	9	84603746	84603746	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr9:84603746C>G	uc004amn.2	+	1	60	c.13C>G	c.(13-15)CTC>GTC	p.L5V		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	5						integral to membrane					0						GGAGAATATCCTCTGTTTTCT	0.507000												
PAPPA	5069	broad.mit.edu	37	9	119114988	119114988	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr9:119114988A>G	uc004bjn.2	+	16	4349	c.3968A>G	c.(3967-3969)AAC>AGC	p.N1323S	PAPPA_uc011lxq.1_Missense_Mutation_p.N698S	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1323	Sushi 2.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CTTCCAGGCAACAACAGCCTC	0.547000												
PAPPA	5069	broad.mit.edu	37	9	119115107	119115107	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr9:119115107C>T	uc004bjn.2	+	16	4468	c.4087C>T	c.(4087-4089)CGA>TGA	p.R1363*	PAPPA_uc011lxq.1_Nonsense_Mutation_p.R738*	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	1363	Sushi 3.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CGCCCGGTGCCGAGAGAATAA	0.572000												
GAPVD1	26130	broad.mit.edu	37	9	128074745	128074745	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr9:128074745A>C	uc010mwx.2	+	9	1782	c.1456A>C	c.(1456-1458)AGC>CGC	p.S486R	GAPVD1_uc011lzs.1_Missense_Mutation_p.S486R|GAPVD1_uc004bpp.2_Missense_Mutation_p.S486R|GAPVD1_uc004bpq.2_Missense_Mutation_p.S486R|GAPVD1_uc004bpr.2_Missense_Mutation_p.S486R|GAPVD1_uc004bps.2_Missense_Mutation_p.S486R|GAPVD1_uc010mwy.1_Missense_Mutation_p.S345R	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	486					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TCGGAGCAGAAGCCGCACCAA	0.338000												
SPTAN1	6709	broad.mit.edu	37	9	131353798	131353798	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr9:131353798C>T	uc004bvl.3	+	22	3162	c.3049C>T	c.(3049-3051)CCG>TCG	p.P1017S	SPTAN1_uc011mbg.1_Missense_Mutation_p.P1017S|SPTAN1_uc011mbh.1_Missense_Mutation_p.P1029S|SPTAN1_uc004bvm.3_Missense_Mutation_p.P1017S|SPTAN1_uc004bvn.3_Missense_Mutation_p.P1017S	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1017	SH3.		P -> S (in a breast cancer sample; somatic mutation).		actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton	p.P1017S(1)		breast(5)|ovary(4)|pancreas(1)	10						GGGTTTTGTGCCGGCTGCGTA	0.522000												
VAV2	7410	broad.mit.edu	37	9	136648670	136648670	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chr9:136648670C>T	uc004ces.2	-	19	1724	c.1678G>A	c.(1678-1680)GGG>AGG	p.G560R	VAV2_uc004cer.2_Missense_Mutation_p.G550R|VAV2_uc004cet.1_Missense_Mutation_p.G99R	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	560	Phorbol-ester/DAG-type.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		TTGTGTGCCCCGACGCCACAC	0.632000												
MID1	4281	broad.mit.edu	37	X	10450560	10450560	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chrX:10450560G>A	uc004cte.3	-	5	1164	c.973C>T	c.(973-975)CAT>TAT	p.H325Y	MID1_uc004ctd.3_Missense_Mutation_p.H36Y|MID1_uc004ctg.3_Missense_Mutation_p.H325Y|MID1_uc004cth.3_Missense_Mutation_p.H287Y|MID1_uc004ctk.3_Missense_Mutation_p.H325Y|MID1_uc004cti.3_Missense_Mutation_p.H325Y|MID1_uc004ctj.3_Missense_Mutation_p.H325Y|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Missense_Mutation_p.H376Y|MID1_uc004ctn.1_Missense_Mutation_p.H325Y|MID1_uc004cto.1_Missense_Mutation_p.H287Y|MID1_uc010ndw.1_Missense_Mutation_p.H36Y|MID1_uc004cts.1_Missense_Mutation_p.H92Y|MID1_uc004ctt.2_Missense_Mutation_p.H376Y|MID1_uc004ctu.2_Missense_Mutation_p.H325Y|MID1_uc004ctv.2_Missense_Mutation_p.H338Y|MID1_uc004ctw.2_Missense_Mutation_p.H287Y|MID1_uc010ndy.1_Missense_Mutation_p.H289Y|MID1_uc004ctc.3_Missense_Mutation_p.H92Y|MID1_uc004ctp.1_Intron|MID1_uc004ctq.1_Missense_Mutation_p.H92Y|MID1_uc004ctr.1_Missense_Mutation_p.H92Y|MID1_uc010ndu.1_Missense_Mutation_p.H92Y|MID1_uc010ndv.1_Missense_Mutation_p.H36Y|MID1_uc010ndx.1_RNA	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	325	COS.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						AAACGCGCATGATCATTCTCC	0.527000												
FAM48B2	170067	broad.mit.edu	37	X	24330059	24330059	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chrX:24330059C>G	uc011mjw.1	-	1	1374	c.1374G>C	c.(1372-1374)GAG>GAC	p.E458D		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	458											0						GTGGATGTTTCTCTCCCTTCC	0.552000												
NAP1L3	4675	broad.mit.edu	37	X	92928030	92928030	+	Silent	SNP	A	A	G			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chrX:92928030A>G	uc004efq.2	-	1	579	c.274T>C	c.(274-276)TTG>CTG	p.L92L	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	92					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						TTTGTTCCCAACGGGGCCCGC	0.398000												
KLHL13	90293	broad.mit.edu	37	X	117033040	117033040	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6705-01A-12D-1882-08	TCGA-BR-6705-10A-01D-1882-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	02c5e07a-0986-4860-b192-0cf8d4fce7ce	ba6c6e1c-d481-4e30-a777-a943c3566d4b	g.chrX:117033040C>T	uc004eql.2	-	7	1861	c.1799G>A	c.(1798-1800)CGT>CAT	p.R600H	KLHL13_uc004eqk.2_Missense_Mutation_p.R549H|KLHL13_uc011mtn.1_Missense_Mutation_p.R440H|KLHL13_uc011mto.1_Missense_Mutation_p.R594H|KLHL13_uc011mtp.1_Missense_Mutation_p.R602H|KLHL13_uc004eqm.2_Missense_Mutation_p.R549H|KLHL13_uc011mtq.1_Missense_Mutation_p.R584H	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	600	Kelch 6.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						TACCATACAACGATTATTCCA	0.438000