Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
MIIP	60672	broad.mit.edu	37	1	12091805	12091805	+	Silent	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr1:12091805G>A	uc001ato.1	+	10	1287	c.1107G>A	c.(1105-1107)CCG>CCA	p.P369P		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	369										ovary(1)	1						TGCTGCCCCCGACCCCGACCT	0.652000												
CSMD2	114784	broad.mit.edu	37	1	34006124	34006124	+	Splice_Site	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr1:34006124C>T	uc001bxn.1	-	59	9228	c.9199_splice	c.e59+1	p.P3067_splice	CSMD2_uc001bxm.1_Splice_Site_p.P3211_splice	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2							integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AAGCAACTTACGGAAACACTG	0.582000												
FLG	2312	broad.mit.edu	37	1	152275780	152275780	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr1:152275780G>A	uc001ezu.1	-	3	11618	c.11582C>T	c.(11581-11583)TCC>TTC	p.S3861F		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3861	Filaggrin 23.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTAACACTGGATCCCTGGCG	0.577000									Ichthyosis			
FLG	2312	broad.mit.edu	37	1	152283700	152283700	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr1:152283700C>T	uc001ezu.1	-	3	3698	c.3662G>A	c.(3661-3663)CGT>CAT	p.R1221H	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1221	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTGTCCTTACGAGTTTGTCT	0.567000									Ichthyosis			
CNTN2	6900	broad.mit.edu	37	1	205039136	205039136	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr1:205039136G>A	uc001hbr.2	+	18	2647	c.2378G>A	c.(2377-2379)CGC>CAC	p.R793H	CNTN2_uc001hbq.1_Missense_Mutation_p.R684H|CNTN2_uc001hbs.2_Missense_Mutation_p.R581H	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	793	Fibronectin type-III 2.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGCTACAACCGCCGCGGGGAT	0.662000												
OBSCN	84033	broad.mit.edu	37	1	228399542	228399542	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr1:228399542G>A	uc009xez.1	+	2	102	c.58G>A	c.(58-60)GTG>ATG	p.V20M	OBSCN_uc001hsn.2_Missense_Mutation_p.V20M|uc001hsm.1_Intron	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	20	Ig-like 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CAAGGCCTTCGTGGTGTCGGT	0.677000												
CAMK1D	57118	broad.mit.edu	37	10	12866468	12866468	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr10:12866468G>C	uc001ilo.2	+	9	1073	c.838G>C	c.(838-840)GCT>CCT	p.A280P	CAMK1D_uc001iln.2_Missense_Mutation_p.A280P	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	280	Autoinhibitory domain (By similarity).					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		TTTCAGGATCGCTGGTGACAC	0.527000												
MYO3A	53904	broad.mit.edu	37	10	26241113	26241113	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr10:26241113A>C	uc001isn.2	+	3	434	c.74A>C	c.(73-75)GAG>GCG	p.E25A	MYO3A_uc009xko.1_Missense_Mutation_p.E25A|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.E25A|MYO3A_uc001ism.2_Missense_Mutation_p.E25A	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	25	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.E25_I27>I(1)		ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GAAATCACTGAGACAATTGGC	0.328000												
EXOSC1	51013	broad.mit.edu	37	10	99196244	99196244	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr10:99196244G>C	uc001kni.2	-	8	572	c.546C>G	c.(544-546)TTC>TTG	p.F182L	EXOSC1_uc009xvp.1_RNA	NM_016046	NP_057130	Q9Y3B2	EXOS1_HUMAN	exosomal core protein CSL4	182					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding				0		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		CTACTTTCCGGAATTCTTTAG	0.507000												
HBG1	3047	broad.mit.edu	37	11	5269648	5269648	+	Missense_Mutation	SNP	C	C	T	rs41330850		TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr11:5269648C>T	uc001mah.1	-	3	438	c.385G>A	c.(385-387)GCT>ACT	p.A129T	HBG2_uc001mai.1_Missense_Mutation_p.A129T	NM_000559	NP_000550	P69891	HBG1_HUMAN	A-gamma globin	129			A -> T (in Baskent).		blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCAGGAAGCCTGCACCTCA	0.502000												
OR10A4	283297	broad.mit.edu	37	11	6898750	6898750	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr11:6898750A>G	uc010rat.1	+	1	872	c.872A>G	c.(871-873)TAC>TGC	p.Y291C		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCCATCATCTACAGCTCAAGG	0.502000												
RBM7	10179	broad.mit.edu	37	11	114273598	114273598	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr11:114273598A>G	uc001pov.2	+	3	318	c.308A>G	c.(307-309)CAT>CGT	p.H103R	C11orf71_uc001pot.1_5'Flank|C11orf71_uc001pou.3_5'Flank|RBM7_uc001pow.2_Missense_Mutation_p.H103R|RBM7_uc001pox.2_5'UTR	NM_016090	NP_057174	Q9Y580	RBM7_HUMAN	RNA binding motif protein 7	103					meiosis		nucleotide binding|protein binding|RNA binding			ovary(2)	2		all_cancers(61;5.06e-12)|all_epithelial(67;5.3e-06)|all_hematologic(158;7.68e-05)|Acute lymphoblastic leukemia(157;0.000966)|Melanoma(852;0.00153)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.0818)|Prostate(24;0.104)		BRCA - Breast invasive adenocarcinoma(274;2.56e-06)|Epithelial(105;4.17e-05)|all cancers(92;0.000348)		CCCCAACATCATGTTGGAAAT	0.338000												
POU2F3	25833	broad.mit.edu	37	11	120168982	120168982	+	Silent	SNP	C	C	T	rs139585451		TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr11:120168982C>T	uc001pxc.2	+	4	243	c.141C>T	c.(139-141)ACC>ACT	p.T47T	POU2F3_uc010rzk.1_5'UTR|POU2F3_uc010rzl.1_5'UTR	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	47					negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		AGATTAAAACCGAAGATCTCA	0.542000												
GRIK4	2900	broad.mit.edu	37	11	120702685	120702685	+	Silent	SNP	C	C	T	rs148308915	byFrequency	TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr11:120702685C>T	uc001pxn.2	+	7	923	c.636C>T	c.(634-636)ACC>ACT	p.T212T	GRIK4_uc009zav.1_Silent_p.T212T|GRIK4_uc009zaw.1_Silent_p.T212T|GRIK4_uc009zax.1_Silent_p.T212T	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	212	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	ACGACAAGACCGCCACCATCA	0.637000												
PTPN6	5777	broad.mit.edu	37	12	7065608	7065608	+	Silent	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr12:7065608C>T	uc001qsb.2	+	9	1193	c.951C>T	c.(949-951)AAC>AAT	p.N317N	PTPN6_uc001qsa.1_Silent_p.N319N|PTPN6_uc010sfr.1_Silent_p.N278N|PTPN6_uc009zfl.1_Silent_p.N317N|PTPN6_uc010sfs.1_Silent_p.N305N	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	317	Tyrosine-protein phosphatase.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						CTGATGAGAACGCTAAGACCT	0.607000												
ERBB3	2065	broad.mit.edu	37	12	56489547	56489547	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr12:56489547T>A	uc001sjh.2	+	17	2205	c.2012T>A	c.(2011-2013)ATT>AAT	p.I671N	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Missense_Mutation_p.I28N|ERBB3_uc010sqc.1_Missense_Mutation_p.I612N|ERBB3_uc009zok.2_Missense_Mutation_p.I113N|ERBB3_uc001sjk.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	671	Cytoplasmic (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GGGCGCCGGATTCAGAATAAA	0.453000												
SDR9C7	121214	broad.mit.edu	37	12	57323335	57323335	+	Missense_Mutation	SNP	C	C	T	rs141626978		TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr12:57323335C>T	uc010sqw.1	-	3	563	c.563G>A	c.(562-564)CGT>CAT	p.R188H		NM_148897	NP_683695	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C,	188						cytoplasm	binding|oxidoreductase activity			central_nervous_system(1)	1						GTAGAGCTCACGCCTGGGAAA	0.532000												
DAO	1610	broad.mit.edu	37	12	109286789	109286789	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr12:109286789C>T	uc001tnr.3	+	6	637	c.484C>T	c.(484-486)CGG>TGG	p.R162W	DAO_uc001tnq.3_Intron|DAO_uc009zvb.2_RNA|DAO_uc001tns.3_RNA	NM_001917	NP_001908	P14920	OXDA_HUMAN	D-amino-acid oxidase	162					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			ovary(1)|skin(1)	2						GTTCTTCCAGCGGAAAGTGGA	0.557000												
ACAD10	80724	broad.mit.edu	37	12	112140003	112140003	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr12:112140003A>G	uc001tsq.2	+	3	425	c.225A>G	c.(223-225)ATA>ATG	p.I75M	ACAD10_uc009zvw.2_Missense_Mutation_p.I75M|ACAD10_uc001tso.3_Missense_Mutation_p.I75M|ACAD10_uc001tsp.2_Missense_Mutation_p.I75M|ACAD10_uc009zvx.2_Missense_Mutation_p.I75M	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	75							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						CTGGAACTATATTAAAGGCCT	0.413000												
ZNF605	100289635	broad.mit.edu	37	12	133501996	133501996	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr12:133501996G>A	uc001ulh.2	-	5	2214	c.1889C>T	c.(1888-1890)TCG>TTG	p.S630L	ZNF605_uc001uli.2_Missense_Mutation_p.S661L|ZNF605_uc001ulj.2_Missense_Mutation_p.S630L	NM_183238	NP_899061	Q86T29	ZN605_HUMAN	zinc finger protein 605 isoform 1	630	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00227)|all_epithelial(31;0.142)		OV - Ovarian serous cystadenocarcinoma(86;9.24e-09)|Epithelial(86;2.11e-07)|all cancers(50;5.27e-06)		CATAAGCTGCGACTTCCTGTT	0.383000												
KLHL1	57626	broad.mit.edu	37	13	70314635	70314635	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr13:70314635T>C	uc001vip.2	-	8	2487	c.1693A>G	c.(1693-1695)AGC>GGC	p.S565G	KLHL1_uc010thm.1_Missense_Mutation_p.S504G	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	565	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TTCAGATAGCTCCAGCCATCA	0.383000												
RALGAPA1	253959	broad.mit.edu	37	14	36143463	36143463	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr14:36143463A>C	uc001wti.2	-	23	3713	c.3322T>G	c.(3322-3324)TCA>GCA	p.S1108A	RALGAPA1_uc010amp.2_5'Flank|RALGAPA1_uc001wtj.2_Missense_Mutation_p.S1108A|RALGAPA1_uc010tpv.1_Missense_Mutation_p.S1121A|RALGAPA1_uc010tpw.1_Missense_Mutation_p.S1155A	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1108					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TTATCAGTTGAAATGCCAAGG	0.323000												
RIN3	79890	broad.mit.edu	37	14	93118183	93118183	+	Silent	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr14:93118183G>A	uc001yap.2	+	6	941	c.789G>A	c.(787-789)CCG>CCA	p.P263P	RIN3_uc010auk.2_5'UTR|RIN3_uc001yaq.2_Silent_p.P188P|RIN3_uc001yar.1_5'UTR|RIN3_uc001yas.1_5'UTR	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	263	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				GCCCTTTGCCGCCCACCTCTG	0.453000												
CAPN3	825	broad.mit.edu	37	15	42652189	42652189	+	Silent	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr15:42652189G>A	uc001zpn.1	+	1	492	c.186G>A	c.(184-186)GAG>GAA	p.E62E	CAPN3_uc001zpk.1_Intron|CAPN3_uc001zpl.1_Intron|CAPN3_uc010udf.1_Intron|CAPN3_uc010udg.1_Intron|CAPN3_uc001zpo.1_Silent_p.E62E|CAPN3_uc001zpp.1_Silent_p.E62E	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	62					muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		AGACATTCGAGCAACTTCACA	0.473000												
LOXL1	4016	broad.mit.edu	37	15	74239441	74239441	+	Silent	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr15:74239441C>T	uc002awc.1	+	4	1719	c.1383C>T	c.(1381-1383)TAC>TAT	p.Y461Y	LOXL1_uc002awd.1_5'Flank	NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	461	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0						TCAGCCACTACGACCTACTGG	0.592000												
ZNF710	374655	broad.mit.edu	37	15	90611201	90611201	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr15:90611201G>A	uc002bov.1	+	2	955	c.832G>A	c.(832-834)GTG>ATG	p.V278M		NM_198526	NP_940928	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			GGACATCAACGTGCAGATTGA	0.622000												
E4F1	1877	broad.mit.edu	37	16	2284270	2284270	+	Missense_Mutation	SNP	C	C	T	rs142977286		TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr16:2284270C>T	uc002cpm.2	+	10	1522	c.1474C>T	c.(1474-1476)CGC>TGC	p.R492C	E4F1_uc010bsi.2_Missense_Mutation_p.R492C|E4F1_uc010bsj.2_Intron|DNASE1L2_uc002cpn.2_5'Flank|DNASE1L2_uc002cpo.2_5'Flank|DNASE1L2_uc002cpp.2_5'Flank|DNASE1L2_uc002cpq.2_5'Flank	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	492	Mediates interaction with CDKN2A.|Interaction with BMI1.|C2H2-type 6.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GCGCCGCTTCCGCTGTGGCGA	0.667000												
C16orf53	79447	broad.mit.edu	37	16	29828032	29828032	+	Silent	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr16:29828032C>T	uc002dug.3	+	1	505	c.186C>T	c.(184-186)TCC>TCT	p.S62S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_024516	NP_078792	Q9BTK6	PA1_HUMAN	PTIP-associated 1 protein	62	Glu-rich.										0						GTGAGGGGTCCGGGGGCGAGG	0.716000											OREG0023722	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
TMCO7	79613	broad.mit.edu	37	16	68934404	68934404	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr16:68934404T>C	uc002ewi.3	+	8	1457	c.1445T>C	c.(1444-1446)CTT>CCT	p.L482P		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	482	Helical; (Potential).					integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		CTGGGAGTGCTTTTTCTTCTC	0.388000												
ST3GAL2	6483	broad.mit.edu	37	16	70428945	70428945	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr16:70428945G>A	uc002eyw.2	-	2	2581	c.473C>T	c.(472-474)TCG>TTG	p.S158L	ST3GAL2_uc002eyx.2_Missense_Mutation_p.S158L	NM_006927	NP_008858	Q16842	SIA4B_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	158	Lumenal (Potential).				amino sugar metabolic process	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			ovary(1)	1		Ovarian(137;0.0694)				CAGGTTGCCCGAGTTCCCCAC	0.652000												
PRPF8	10594	broad.mit.edu	37	17	1559814	1559814	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr17:1559814G>A	uc002fte.2	-	36	5779	c.5665C>T	c.(5665-5667)CTC>TTC	p.L1889F		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1889	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GGGAGTTGGAGCTCCGATCCT	0.478000												
KRT25	147183	broad.mit.edu	37	17	38904587	38904587	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr17:38904587C>T	uc002hve.2	-	8	1356	c.1295G>A	c.(1294-1296)CGC>CAC	p.R432H		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	432	Tail.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				TATTTTGCTGCGTTGGTCTAC	0.403000												
KIF2B	84643	broad.mit.edu	37	17	51900906	51900906	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr17:51900906G>A	uc002iua.2	+	1	668	c.512G>A	c.(511-513)CGA>CAA	p.R171Q	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	171	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CAGGAGATCCGAGCTAGACGC	0.532000												
PIK3C3	5289	broad.mit.edu	37	18	39637994	39637994	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr18:39637994C>T	uc002lap.2	+	22	2469	c.2411C>T	c.(2410-2412)ACG>ATG	p.T804M	PIK3C3_uc010xcl.1_Missense_Mutation_p.T741M|PIK3C3_uc002laq.2_Missense_Mutation_p.T289M	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	804	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						CAGTGTTACACGGCTTTCCTC	0.398000										TSP Lung(28;0.18)		
KATNAL2	83473	broad.mit.edu	37	18	44579393	44579393	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr18:44579393A>G	uc002lco.2	+	2	243	c.49A>G	c.(49-51)ATT>GTT	p.I17V	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Intron	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	89						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						ATACCCCAAAATTGTCAAAAA	0.338000												
CXXC1	30827	broad.mit.edu	37	18	47812195	47812195	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr18:47812195C>T	uc002leq.3	-	5	1296	c.563G>A	c.(562-564)CGG>CAG	p.R188Q	CXXC1_uc002lep.3_Missense_Mutation_p.R45Q|CXXC1_uc002ler.3_Missense_Mutation_p.R188Q|CXXC1_uc010doy.2_Missense_Mutation_p.R188Q|CXXC1_uc002les.2_Missense_Mutation_p.R188Q	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	188	CXXC-type.				histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CTTCATGTCCCGACAGAAATC	0.552000												
MUC16	94025	broad.mit.edu	37	19	9071751	9071751	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr19:9071751T>G	uc002mkp.2	-	3	15899	c.15695A>C	c.(15694-15696)AAA>ACA	p.K5232T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5234	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGGAAATTTTGCTAGAAGA	0.488000												
CC2D1A	54862	broad.mit.edu	37	19	14031623	14031623	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr19:14031623G>A	uc002mxo.2	+	14	1828	c.1529G>A	c.(1528-1530)CGA>CAA	p.R510Q	CC2D1A_uc002mxp.2_Missense_Mutation_p.R510Q|CC2D1A_uc010dzh.2_Missense_Mutation_p.R79Q|CC2D1A_uc002mxq.1_Missense_Mutation_p.R155Q	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	510	Potential.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			GCCGCACTGCGAGCCAAGCAG	0.647000												
ZNF208	7757	broad.mit.edu	37	19	22155029	22155029	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr19:22155029T>A	uc002nqp.2	-	5	2656	c.2507A>T	c.(2506-2508)AAG>ATG	p.K836M	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATGAGTTTTCTTATGTTTACT	0.368000												
ZNF600	162966	broad.mit.edu	37	19	53269036	53269036	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr19:53269036C>A	uc002qab.3	-	3	2259	c.1973G>T	c.(1972-1974)AGA>ATA	p.R658I		NM_198457	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	658	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		AGGATGAATTCTCCTATGTCT	0.383000												
APOB	338	broad.mit.edu	37	2	21229930	21229930	+	Silent	SNP	G	G	A	rs138010392	byFrequency	TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr2:21229930G>A	uc002red.2	-	26	9938	c.9810C>T	c.(9808-9810)TTC>TTT	p.F3270F		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3270					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACACATAGCCGAATGCCGACA	0.473000												
HEATR5B	54497	broad.mit.edu	37	2	37289090	37289090	+	Missense_Mutation	SNP	A	A	T	rs147152129		TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr2:37289090A>T	uc002rpp.1	-	11	1784	c.1688T>A	c.(1687-1689)ATG>AAG	p.M563K		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	563							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				ACCTAAAGTCATAAGTGCTCC	0.373000												
GLI2	2736	broad.mit.edu	37	2	121712927	121712927	+	Silent	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr2:121712927G>A	uc010flp.2	+	4	594	c.564G>A	c.(562-564)GCG>GCA	p.A188A	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Intron|GLI2_uc002tmu.3_Intron|GLI2_uc002tmv.1_Intron|GLI2_uc010flo.1_Silent_p.A63A|GLI2_uc002tmw.1_Silent_p.A188A	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	188					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				GCCACCCCGCGCCCTACGGGG	0.667000												
PLCL1	5334	broad.mit.edu	37	2	198950136	198950136	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr2:198950136T>G	uc010fsp.2	+	2	2186	c.1895T>G	c.(1894-1896)GTT>GGT	p.V632G	PLCL1_uc002uuv.3_Missense_Mutation_p.V553G	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	632	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GAGGATTTTGTTAATTATAAT	0.378000												
ANKRD5	63926	broad.mit.edu	37	20	10023849	10023849	+	Silent	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr20:10023849C>T	uc002wno.2	+	4	819	c.426C>T	c.(424-426)GTC>GTT	p.V142V	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Silent_p.V142V|ANKRD5_uc010gbz.2_5'UTR	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	142							calcium ion binding			ovary(1)|breast(1)	2						GTGCAGATGTCAACAATTCTA	0.418000												
MACROD2	140733	broad.mit.edu	37	20	15913947	15913947	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr20:15913947A>C	uc002wou.2	+	11	1066	c.802A>C	c.(802-804)AGT>CGT	p.S268R	MACROD2_uc002wot.2_Missense_Mutation_p.S268R|MACROD2_uc002woz.2_Missense_Mutation_p.S33R|MACROD2_uc002wpb.2_Missense_Mutation_p.S33R	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	268	Glu-rich.										0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				GGAGAAGCAAAGTGTGGAAGA	0.418000												
NINL	22981	broad.mit.edu	37	20	25457205	25457205	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr20:25457205G>A	uc002wux.1	-	17	2796	c.2722C>T	c.(2722-2724)CGC>TGC	p.R908C	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	908					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GGCTGCATGCGTGACCACCTC	0.706000												
BPIL1	80341	broad.mit.edu	37	20	31598877	31598877	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr20:31598877G>C	uc002wyj.2	+	3	351	c.157G>C	c.(157-159)GTC>CTC	p.V53L		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	53						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						GCAGGTCACTGTCCCTCATTT	0.617000												
PREX1	57580	broad.mit.edu	37	20	47262400	47262400	+	Silent	SNP	G	G	A	rs141398646	byFrequency	TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr20:47262400G>A	uc002xtw.1	-	26	3524	c.3501C>T	c.(3499-3501)CGC>CGT	p.R1167R	PREX1_uc002xtv.1_Silent_p.R464R	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1167					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			TGTAGGAGTCGCGATAACTCA	0.602000												
CDH4	1002	broad.mit.edu	37	20	60503377	60503377	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr20:60503377C>T	uc002ybn.1	+	12	1915	c.1901C>T	c.(1900-1902)ACG>ATG	p.T634M	CDH4_uc002ybp.1_Missense_Mutation_p.T560M	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	634	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ATCAACATCACGGCGGCCGAC	0.622000												
COL20A1	57642	broad.mit.edu	37	20	61945434	61945434	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr20:61945434C>T	uc011aau.1	+	19	2469	c.2369C>T	c.(2368-2370)CCA>CTA	p.P790L	COL20A1_uc011aav.1_Missense_Mutation_p.P611L	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	790	Fibronectin type-III 6.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GTCTCTGTGCCAGGAGCCAGG	0.642000												
TMPRSS15	5651	broad.mit.edu	37	21	19666657	19666657	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr21:19666657C>T	uc002ykw.2	-	21	2447	c.2416G>A	c.(2416-2418)GGC>AGC	p.G806S		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	806	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						AGCAGTCGGCCGCCATAATAC	0.557000												
CHEK2	11200	broad.mit.edu	37	22	29121096	29121096	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr22:29121096T>C	uc003adu.1	-	4	533	c.461A>G	c.(460-462)AAC>AGC	p.N154S	CHEK2_uc003ads.1_Intron|CHEK2_uc010gvh.1_Intron|CHEK2_uc010gvi.1_Missense_Mutation_p.N154S|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.N197S|CHEK2_uc003adv.1_Missense_Mutation_p.N154S|CHEK2_uc003adw.1_Missense_Mutation_p.N154S|CHEK2_uc003adx.1_5'UTR|CHEK2_uc003ady.1_Missense_Mutation_p.N154S|CHEK2_uc003adz.1_Intron	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	154	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						AATGTAAGAGTTTTTAGGACC	0.348000			F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer			
RBMS3	27303	broad.mit.edu	37	3	29938904	29938904	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr3:29938904C>T	uc003cel.2	+	9	1056	c.826C>T	c.(826-828)CGC>TGC	p.R276C	RBMS3_uc003cek.2_Missense_Mutation_p.R276C|RBMS3_uc010hfq.2_Missense_Mutation_p.R289C|RBMS3_uc003cem.2_Missense_Mutation_p.R275C|RBMS3_uc010hfr.2_Missense_Mutation_p.R276C	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	276						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				TGCAACCAACCGCATGATTCC	0.433000												
RHOA	387	broad.mit.edu	37	3	49405969	49405969	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr3:49405969A>C	uc003cwu.2	-	3	445	c.169T>G	c.(169-171)TTG>GTG	p.L57V	RHOA_uc010hku.2_5'UTR	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	57					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	GTGTCCCACAAAGCCAACTCT	0.463000												
ADRA2C	152	broad.mit.edu	37	4	3769558	3769558	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr4:3769558C>T	uc003ghm.2	+	1	1263	c.1225C>T	c.(1225-1227)CGC>TGC	p.R409C	ADRA2C_uc010icx.2_Intron	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	409	Extracellular (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CGGCATCTGCCGCGAGGCCTG	0.597000												
TECRL	253017	broad.mit.edu	37	4	65188509	65188509	+	Silent	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr4:65188509G>A	uc003hcv.2	-	4	442	c.333C>T	c.(331-333)GGC>GGT	p.G111G	TECRL_uc003hcw.2_Silent_p.G111G	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	111					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						AAAAAGGCCCGCCtaaaataa	0.308000												
TBCK	93627	broad.mit.edu	37	4	107154126	107154126	+	Silent	SNP	T	T	G	rs55956749	byFrequency	TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr4:107154126T>G	uc010ilv.2	-	17	1973	c.1608A>C	c.(1606-1608)GTA>GTC	p.V536V	TBCK_uc003hyb.2_Silent_p.V279V|TBCK_uc003hye.2_Silent_p.V497V|TBCK_uc003hyc.2_Silent_p.V473V|TBCK_uc003hyd.2_Silent_p.V364V|TBCK_uc003hyf.2_Silent_p.V536V	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	536	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						GATGAGACACTACCCAGGCTT	0.368000												
FAT4	79633	broad.mit.edu	37	4	126412194	126412194	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr4:126412194A>C	uc003ifj.3	+	17	14217	c.14217A>C	c.(14215-14217)CAA>CAC	p.Q4739H	FAT4_uc011cgp.1_Missense_Mutation_p.Q2980H|FAT4_uc003ifi.1_Missense_Mutation_p.Q2216H	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4739	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACACCTGCCAACCTGGCATTT	0.483000												
FSTL5	56884	broad.mit.edu	37	4	162307467	162307467	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr4:162307467C>T	uc003iqh.2	-	16	2412	c.1976G>A	c.(1975-1977)GGC>GAC	p.G659D	FSTL5_uc003iqi.2_Missense_Mutation_p.G658D|FSTL5_uc010iqv.2_Missense_Mutation_p.G649D|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	659						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GAAGTAGTAGCCTCCCAAGTG	0.438000												
C5orf42	65250	broad.mit.edu	37	5	37201824	37201824	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr5:37201824G>A	uc011cpa.1	-	19	3607	c.3376C>T	c.(3376-3378)CTT>TTT	p.L1126F	C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.L201F|C5orf42_uc011cpb.1_Missense_Mutation_p.L7F	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1126										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GTCTCCGAAAGAATATCTGCA	0.418000												
APC	324	broad.mit.edu	37	5	112174605	112174605	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr5:112174605G>A	uc010jby.2	+	16	3694	c.3314G>A	c.(3313-3315)CGG>CAG	p.R1105Q	APC_uc011cvt.1_Missense_Mutation_p.R1087Q|APC_uc003kpz.3_Missense_Mutation_p.R1105Q|APC_uc003kpy.3_Missense_Mutation_p.R1105Q|APC_uc010jbz.2_Missense_Mutation_p.R822Q|APC_uc010jca.2_Missense_Mutation_p.R405Q	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1105	Ser-rich.|Responsible for down-regulation through a process mediated by direct ubiquitination.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TACAGGTCACGGGGAGCCAAT	0.398000		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)		
DMXL1	1657	broad.mit.edu	37	5	118533559	118533559	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr5:118533559T>A	uc003ksd.2	+	32	7834	c.7653T>A	c.(7651-7653)TAT>TAA	p.Y2551*	DMXL1_uc010jcl.1_Nonsense_Mutation_p.Y2551*	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2551										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CTCAAAATTATATCGCAAGTC	0.438000												
TIFAB	497189	broad.mit.edu	37	5	134785162	134785162	+	Silent	SNP	A	A	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr5:134785162A>G	uc003law.3	-	2	669	c.468T>C	c.(466-468)CCT>CCC	p.P156P	C5orf20_uc003lav.2_5'Flank	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	TIFA-related protein TIFAB	156											0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AACCAGGGGGAGGCTGCCCCT	0.582000												
PCDHA13	56136	broad.mit.edu	37	5	140261955	140261955	+	Silent	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr5:140261955C>T	uc003lif.2	+	1	102	c.102C>T	c.(100-102)TCC>TCT	p.S34S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.S34S|PCDHA13_uc003lid.2_Silent_p.S34S	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	34	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCACTACTCCGTCCCCGAGG	0.662000												
EYS	346007	broad.mit.edu	37	6	66200566	66200566	+	Silent	SNP	T	T	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr6:66200566T>C	uc011dxu.1	-	5	1321	c.783A>G	c.(781-783)CAA>CAG	p.Q261Q	EYS_uc003peq.2_Silent_p.Q261Q|EYS_uc003per.1_Silent_p.Q261Q|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	261	EGF-like 3.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						AGACATGTGGTTGACACTGGC	0.308000												
EPHA7	2045	broad.mit.edu	37	6	93956675	93956675	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr6:93956675C>T	uc003poe.2	-	15	2802	c.2561G>A	c.(2560-2562)CGT>CAT	p.R854H	EPHA7_uc003pof.2_Missense_Mutation_p.R849H|EPHA7_uc011eac.1_Missense_Mutation_p.R850H	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	854	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGCTGGTAAACGATAACCTTC	0.388000												
RSPO3	84870	broad.mit.edu	37	6	127471624	127471624	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr6:127471624A>C	uc003qar.2	+	3	633	c.343A>C	c.(343-345)AAA>CAA	p.K115Q	RSPO3_uc003qas.1_Missense_Mutation_p.K115Q	NM_032784	NP_116173	Q9BXY4	RSPO3_HUMAN	R-spondin 3 precursor	115	FU 2.					extracellular region	heparin binding				0				GBM - Glioblastoma multiforme(226;0.0555)		CACAAAATGTAAAAGTGGATT	0.368000												
SYNJ2	8871	broad.mit.edu	37	6	158516672	158516672	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr6:158516672T>G	uc003qqx.1	+	27	3842	c.3767T>G	c.(3766-3768)TTT>TGT	p.F1256C	SYNJ2_uc003qqy.1_Missense_Mutation_p.F969C|SYNJ2_uc003qqz.1_Missense_Mutation_p.F873C|SYNJ2_uc003qra.1_Missense_Mutation_p.F599C|SYNJ2_uc010kjp.1_Missense_Mutation_p.F139C	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	1256	Catalytic (By similarity).|Pro-rich.						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		GAAGAACAGTTTGAGCAACAG	0.537000												
WDR27	253769	broad.mit.edu	37	6	170068234	170068234	+	Silent	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr6:170068234G>A	uc003qwx.2	-	5	1024	c.504C>T	c.(502-504)CGC>CGT	p.R168R	WDR27_uc010kkw.1_Silent_p.R168R|WDR27_uc003qwy.2_Intron|WDR27_uc011egw.1_Intron			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GGACTTTGTGGCGGTTATTAA	0.502000												
DLGAP2	9228	broad.mit.edu	37	8	1497743	1497743	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr8:1497743C>T	uc003wpl.2	+	2	981	c.884C>T	c.(883-885)ACG>ATG	p.T295M	DLGAP2_uc003wpm.2_Missense_Mutation_p.T295M	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	374					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TCTACGCTGACGGTCAGCCAG	0.652000												
ANK1	286	broad.mit.edu	37	8	41577290	41577290	+	Silent	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr8:41577290G>A	uc003xok.2	-	10	1080	c.996C>T	c.(994-996)GAC>GAT	p.D332D	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Silent_p.D332D|ANK1_uc003xoj.2_Silent_p.D332D|ANK1_uc003xol.2_Silent_p.D332D|ANK1_uc003xom.2_Silent_p.D365D	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	332	ANK 9.|89 kDa domain.		D -> H (in a breast cancer sample; somatic mutation).		axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton	p.D332H(1)		ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGGTGATGTCGTCTATCTCTG	0.587000												
TRPS1	7227	broad.mit.edu	37	8	116632246	116632246	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr8:116632246T>C	uc003ynz.2	-	2	499	c.40A>G	c.(40-42)AGT>GGT	p.S14G	TRPS1_uc011lhy.1_Missense_Mutation_p.S18G|TRPS1_uc003yny.2_Missense_Mutation_p.S27G|TRPS1_uc010mcy.2_Missense_Mutation_p.S14G	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	14					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TCGCCTTCACTTGCAACGTTT	0.433000									Langer-Giedion_syndrome			
GPR21	2844	broad.mit.edu	37	9	125797424	125797424	+	Silent	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr9:125797424G>A	uc011lzk.1	+	1	579	c.579G>A	c.(577-579)CTG>CTA	p.L193L	RABGAP1_uc004bnl.3_Intron|RABGAP1_uc011lzh.1_Intron|RABGAP1_uc011lzj.1_Intron|GPR21_uc011lzi.1_RNA	NM_005294	NP_005285	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	193	Helical; Name=5; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)	1						ACTTCACCCTGTTCATCGTGA	0.498000												
FAM78A	286336	broad.mit.edu	37	9	134136226	134136226	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr9:134136226G>A	uc004cak.2	-	2	1175	c.835C>T	c.(835-837)CCG>TCG	p.P279S	FAM78A_uc004caj.2_Missense_Mutation_p.P276S	NM_033387	NP_203745	Q5JUQ0	FA78A_HUMAN	hypothetical protein LOC286336	279										ovary(1)	1	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		TGCTTGGGCGGGATCACCACC	0.577000												
SURF6	6838	broad.mit.edu	37	9	136199499	136199499	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr9:136199499G>A	uc004cdb.3	-	4	569	c.491C>T	c.(490-492)GCG>GTG	p.A164V		NM_006753	NP_006744	O75683	SURF6_HUMAN	surfeit 6	164						granular component	DNA binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		CTTCTCTTTCGCCCGCAGCTC	0.687000												
SLC34A3	142680	broad.mit.edu	37	9	140130470	140130470	+	Missense_Mutation	SNP	C	C	T	rs121918238		TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr9:140130470C>T	uc004cmf.1	+	13	1588	c.1402C>T	c.(1402-1404)CGG>TGG	p.R468W	SLC34A3_uc011met.1_Missense_Mutation_p.R468W	NM_080877	NP_543153	Q8N130	NPT2C_HUMAN	solute carrier family 34 (sodium phosphate),	468	Cytoplasmic (Potential).		R -> W (in HHRH).		cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GCCTGCACTGCGGCTGCCCAT	0.692000											OREG0019630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
GPR64	10149	broad.mit.edu	37	X	19045346	19045346	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chrX:19045346C>A	uc004cyx.2	-	11	625	c.461G>T	c.(460-462)AGT>ATT	p.S154I	GPR64_uc004cyy.2_Missense_Mutation_p.S151I|GPR64_uc004cyz.2_Missense_Mutation_p.S140I|GPR64_uc004czb.2_Missense_Mutation_p.S154I|GPR64_uc004czc.2_Missense_Mutation_p.S138I|GPR64_uc004czd.2_Missense_Mutation_p.S130I|GPR64_uc004cze.2_Missense_Mutation_p.S124I|GPR64_uc004czf.2_Missense_Mutation_p.S116I|GPR64_uc004cza.2_Missense_Mutation_p.S132I|GPR64_uc004cyw.2_Missense_Mutation_p.S138I|GPR64_uc010nfj.2_Missense_Mutation_p.S124I	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	154	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					CTTTAATTCACTTAGAGACAG	0.333000												
USP9X	8239	broad.mit.edu	37	X	41043383	41043383	+	Splice_Site	SNP	T	T	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chrX:41043383T>C	uc004dfb.2	+	22	3912	c.3279_splice	c.e22+2	p.E1093_splice	USP9X_uc004dfc.2_Splice_Site_p.E1093_splice	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						CTAACAGAGGTTAGTTTTTGG	0.294000												
FGD1	2245	broad.mit.edu	37	X	54472781	54472781	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chrX:54472781G>A	uc004dtg.2	-	18	3381	c.2647C>T	c.(2647-2649)CGG>TGG	p.R883W		NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	883	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CTGTCAGGCCGCTCCCCTGCC	0.632000												
KIAA2022	340533	broad.mit.edu	37	X	73960013	73960013	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chrX:73960013T>G	uc004eby.2	-	3	4996	c.4379A>C	c.(4378-4380)GAG>GCG	p.E1460A		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1460					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTTACATTTCTCATCTCTCAG	0.433000												
CYSLTR1	10800	broad.mit.edu	37	X	77529240	77529240	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chrX:77529240C>T	uc004edb.2	-	3	404	c.4G>A	c.(4-6)GAT>AAT	p.D2N	CYSLTR1_uc010nma.2_Missense_Mutation_p.D2N|CYSLTR1_uc010nmb.2_Missense_Mutation_p.D2N	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	2	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	CCTGTTTCATCCATGTTTCTC	0.338000												
FAM46D	169966	broad.mit.edu	37	X	79698243	79698243	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chrX:79698243A>C	uc004edl.1	+	5	539	c.205A>C	c.(205-207)AGT>CGT	p.S69R	FAM46D_uc004edm.1_Missense_Mutation_p.S69R	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	69										lung(2)	2						TTCCGTAGCAAGTTACATACT	0.378000												
SLITRK4	139065	broad.mit.edu	37	X	142717006	142717006	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chrX:142717006A>T	uc004fbx.2	-	2	2295	c.1919T>A	c.(1918-1920)GTT>GAT	p.V640D	SLITRK4_uc004fby.2_Missense_Mutation_p.V640D	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	640	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CAGGACAAAAACAAGAAGGCA	0.483000												
GABRA3	2556	broad.mit.edu	37	X	151336800	151336800	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chrX:151336800C>A	uc010ntk.1	-	10	1619	c.1379G>T	c.(1378-1380)CGC>CTC	p.R460L		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	460	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAAGATGATGCGGGAAATTTT	0.498000												
SALL2	6297	broad.mit.edu	37	14	21993502	21993506	+	Frame_Shift_Del	DEL	CTCCT	CTCCT	-			TCGA-BR-6563-01A-13D-2053-08	TCGA-BR-6563-10A-01D-2053-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ef0d519-c910-4490-b9b0-e1e52ae95802	eaffeea4-d428-4d1a-b0bf-3760c79fd5c1	g.chr14:21993501_21993505ACTCCT>A	uc001wbe.3	-	1	639_643	c.357_361AGGAGT>T	c.(355-363)gaggagtctfs	p.E119fs	SALL2_uc010tly.2_Frame_Shift_Del_p.E117fs|SALL2_uc010tlz.1_Frame_Shift_Del_p.E117fs|SALL2_uc001wbf.3_Frame_Shift_Del_p.E117fs|SALL2_uc010tma.1_Frame_Shift_Del_p.E119fs|SALL2_uc001wbg.1_Frame_Shift_Del_p.E119fs	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	Homo sapiens sal-like 2 (Drosophila) (SALL2), mRNA.	119							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		TGCCCTGGAGACTCCTCTCCTCTCC	0.624