Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
VWA1	64856	broad.mit.edu	37	1	1372328	1372328	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:1372328G>A	uc001afs.2	+	2	315	c.95G>A	c.(94-96)CGA>CAA	p.R32Q	VWA1_uc001afr.2_Intron	NM_022834	NP_073745	Q6PCB0	VWA1_HUMAN	von Willebrand factor A domain containing 1	32						basement membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCAGCCCCCCGAGGGGACCTG	0.667000												
ARID1A	8289	broad.mit.edu	37	1	27107162	27107162	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:27107162T>G	uc001bmv.1	+	20	7146	c.6773T>G	c.(6772-6774)CTG>CGG	p.L2258R	ARID1A_uc001bmu.1_Missense_Mutation_p.L2041R|ARID1A_uc001bmx.1_Missense_Mutation_p.L1104R|ARID1A_uc009vsm.1_Missense_Mutation_p.L586R|ARID1A_uc009vsn.1_Missense_Mutation_p.L500R	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2258					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GAATCACGGCTGTTGGACATC	0.527000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
YRDC	79693	broad.mit.edu	37	1	38272879	38272879	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:38272879C>A	uc001cca.1	-	2	411	c.398G>T	c.(397-399)CGT>CTT	p.R133L	C1orf122_uc001ccb.1_5'UTR	NM_024640	NP_078916	Q86U90	YRDC_HUMAN	ischemia/reperfusion inducible protein	133	YrdC-like.				negative regulation of transport	membrane|mitochondrion					0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TACTCTCACACGGCAGTATCT	0.418000												
PTGER3	5733	broad.mit.edu	37	1	71478123	71478123	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:71478123G>A	uc001dfg.1	-	2	1173	c.942C>T	c.(940-942)CAC>CAT	p.H314H	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Silent_p.H314H|PTGER3_uc001dfl.1_Silent_p.H314H|PTGER3_uc009wbm.1_Silent_p.H314H|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Silent_p.H314H|PTGER3_uc009wbn.1_Silent_p.H314H|PTGER3_uc009wbo.2_Silent_p.H314H|PTGER3_uc001dfo.2_Silent_p.H314H|PTGER3_uc001dfp.1_Silent_p.H314H|PTGER3_uc001dfq.2_Silent_p.H314H	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	314	Extracellular (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	GTGTCTTGCAGTGCTCAACTG	0.368000												
EPHX4	253152	broad.mit.edu	37	1	92508453	92508453	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:92508453G>T	uc001don.2	+	3	495	c.391G>T	c.(391-393)GGA>TGA	p.G131*		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	131						integral to membrane	hydrolase activity			central_nervous_system(1)	1						GAGAGGTTATGGAGAAACAGA	0.333000												
NRAS	4893	broad.mit.edu	37	1	115258748	115258748	+	Missense_Mutation	SNP	C	C	A	rs121913250		TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:115258748C>A	uc009wgu.2	-	2	288	c.34G>T	c.(34-36)GGT>TGT	p.G12C		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	12	GTP.		G -> C (in leukemia).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.G12D(333)|p.G12S(118)|p.G12C(71)|p.G12V(54)|p.G12A(36)|p.G12R(16)|p.G12G(4)|p.G12N(1)|p.G12T(1)|p.G12P(1)|p.G12Y(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAACACCACCTGCTCCAACC	0.493000	G12C(P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)		
PDE4DIP	9659	broad.mit.edu	37	1	144916601	144916601	+	Missense_Mutation	SNP	G	G	A	rs146793096	by1000genomes	TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:144916601G>A	uc001elw.3	-	13	2045	c.1754C>T	c.(1753-1755)ACG>ATG	p.T585M	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.T651M|PDE4DIP_uc001emc.1_Missense_Mutation_p.T585M|PDE4DIP_uc001emd.1_Missense_Mutation_p.T585M|PDE4DIP_uc001emb.1_Missense_Mutation_p.T748M|PDE4DIP_uc001eme.1_Missense_Mutation_p.T114M|PDE4DIP_uc001emf.1_Missense_Mutation_p.T372M	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	585	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATGAAGAGACGTCTGTAACTG	0.418000			T	PDGFRB	MPD							
POGZ	23126	broad.mit.edu	37	1	151396574	151396574	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:151396574G>A	uc001eyd.1	-	9	1680	c.1374C>T	c.(1372-1374)GGC>GGT	p.G458G	POGZ_uc001eye.1_Silent_p.G405G|POGZ_uc010pdb.1_Silent_p.G449G|POGZ_uc001eyf.1_Silent_p.G405G|POGZ_uc010pdc.1_Silent_p.G396G|POGZ_uc009wmv.1_Silent_p.G363G|POGZ_uc010pdd.1_Intron	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	458					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGACGGCATCGCCCACGTTCT	0.507000												
TCHH	7062	broad.mit.edu	37	1	152080964	152080964	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:152080964G>A	uc001ezp.2	-	2	4729	c.4729C>T	c.(4729-4731)CGT>TGT	p.R1577C	TCHH_uc009wne.1_Missense_Mutation_p.R1577C	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1577	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTCTGTCACGCTCTTGGCGG	0.597000												
SLC9A11	284525	broad.mit.edu	37	1	173567077	173567077	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:173567077A>G	uc001giz.2	-	4	746	c.323T>C	c.(322-324)GTA>GCA	p.V108A	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	108	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						ATAAAATTCTACATCCAAAGC	0.318000												
ADORA1	134	broad.mit.edu	37	1	203134919	203134919	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:203134919G>A	uc001gze.1	+	4	1305	c.872G>A	c.(871-873)CGC>CAC	p.R291H	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.R291H|ADORA1_uc010pqg.1_Missense_Mutation_p.R223H|ADORA1_uc009xak.1_Silent_p.P216P|ADORA1_uc010pqh.1_Missense_Mutation_p.R324H	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	291	Helical; Name=7; (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	TATGCCTTCCGCATCCAGAAG	0.557000												
OBSCN	84033	broad.mit.edu	37	1	228524806	228524806	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:228524806G>A	uc009xez.1	+	65	16683	c.16639G>A	c.(16639-16641)GTA>ATA	p.V5547I	OBSCN_uc001hsn.2_Missense_Mutation_p.V5547I|OBSCN_uc001hsr.1_Missense_Mutation_p.V175I	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5547					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CACTGAGATGGTATCGGCCAA	0.642000												
RYR2	6262	broad.mit.edu	37	1	237801713	237801713	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr1:237801713G>A	uc001hyl.1	+	45	6969	c.6849G>A	c.(6847-6849)AAG>AAA	p.K2283K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2283	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGTGTCTAAGGGCTATCCAG	0.428000												
PDE6C	5146	broad.mit.edu	37	10	95372701	95372701	+	Silent	SNP	G	G	A	rs140469169	byFrequency	TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr10:95372701G>A	uc001kiu.3	+	1	357	c.219G>A	c.(217-219)GGG>GGA	p.G73G		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	73					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				AGGAGGAGGGGGGCACCCCAG	0.672000												
PYROXD2	84795	broad.mit.edu	37	10	100154955	100154955	+	Silent	SNP	A	A	G			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr10:100154955A>G	uc001kpc.2	-	8	869	c.783T>C	c.(781-783)AGT>AGC	p.S261S	PYROXD2_uc001kpb.2_RNA|PYROXD2_uc001kpd.2_RNA|PYROXD2_uc010qpe.1_Silent_p.S261S	NM_032709	NP_116098	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase	261							oxidoreductase activity			central_nervous_system(1)	1						TCACTCACCCACTCCCCGGAG	0.542000												
NDUFS3	4722	broad.mit.edu	37	11	47604020	47604020	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr11:47604020G>A	uc001nga.2	+	6	709	c.627G>A	c.(625-627)GAG>GAA	p.E209E	NDUFS3_uc001nft.3_Silent_p.E188E	NM_004551	NP_004542	O75489	NDUS3_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 3	209					induction of apoptosis|mitochondrial electron transport, NADH to ubiquinone|negative regulation of cell growth|reactive oxygen species metabolic process|transport	mitochondrial respiratory chain complex I	electron carrier activity|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	GCTATGTTGAGGTAGGAGCCT	0.502000												
CNTF	1270	broad.mit.edu	37	11	58391516	58391516	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr11:58391516C>T	uc001nna.3	+	2	204	c.124C>T	c.(124-126)CAG>TAG	p.Q42*	ZFP91-CNTF_uc010rkm.1_RNA	NM_000614	NP_000605	P26441	CNTF_HUMAN	ciliary neurotrophic factor	42					ciliary neurotrophic factor-mediated signaling pathway|growth|negative regulation of neuron apoptosis|positive regulation of tyrosine phosphorylation of Stat3 protein		ciliary neurotrophic factor receptor binding|growth factor activity|interleukin-6 receptor binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GGTGAAGCATCAGGGCCTGAA	0.507000												
MS4A8B	83661	broad.mit.edu	37	11	60476242	60476242	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr11:60476242C>T	uc001npv.2	+	5	725	c.522C>T	c.(520-522)TAC>TAT	p.Y174Y	MS4A8B_uc009yne.1_Silent_p.Y174Y	NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	174	Extracellular (Potential).					integral to membrane	receptor activity				0						ATTATCCTTACGCCTGGGGTG	0.458000												
BIRC3	330	broad.mit.edu	37	11	102195339	102195339	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr11:102195339G>C	uc001pgx.2	+	3	321	c.99G>C	c.(97-99)ATG>ATC	p.M33I		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	baculoviral IAP repeat-containing protein 3	33	BIR 1.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|skin(1)	4	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TGTACCGAATGTCTACGTATT	0.403000			T	MALT1	MALT							
CACNA1C	775	broad.mit.edu	37	12	2719812	2719812	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr12:2719812G>T	uc009zdu.1	+	29	4037	c.3724G>T	c.(3724-3726)GAG>TAG	p.E1242*	CACNA1C_uc009zdv.1_Nonsense_Mutation_p.E1219*|CACNA1C_uc001qkb.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkc.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qke.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkf.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qjz.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkd.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkg.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc009zdw.1_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkh.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkl.2_Nonsense_Mutation_p.E1242*|CACNA1C_uc001qkn.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qko.2_Nonsense_Mutation_p.E1242*|CACNA1C_uc001qkp.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkr.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qku.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkq.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qks.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qkt.2_Nonsense_Mutation_p.E1222*|CACNA1C_uc001qka.1_Nonsense_Mutation_p.E757*|CACNA1C_uc001qki.1_Nonsense_Mutation_p.E958*|CACNA1C_uc001qkj.1_Nonsense_Mutation_p.E958*|CACNA1C_uc001qkk.1_Nonsense_Mutation_p.E958*|CACNA1C_uc001qkm.1_Nonsense_Mutation_p.E958*	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1242	Helical; Name=S1 of repeat IV; (Potential).|IV.				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CACCTACTTCGAGTACCTGAT	0.587000												
TEAD4	7004	broad.mit.edu	37	12	3131110	3131110	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr12:3131110C>T	uc010sej.1	+	10	1098	c.821C>T	c.(820-822)CCG>CTG	p.P274L	TEAD4_uc010sek.1_Missense_Mutation_p.P231L|TEAD4_uc001qln.2_Missense_Mutation_p.P146L	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	275					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			GACAAATTCCCGGAGAAAAAG	0.517000												
ALG10	84920	broad.mit.edu	37	12	34179654	34179654	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr12:34179654C>T	uc001rlm.2	+	3	1545	c.1226C>T	c.(1225-1227)CCT>CTT	p.P409L		NM_032834	NP_116223	Q5BKT4	AG10A_HUMAN	asparagine-linked glycosylation 10 homolog	409	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			skin(1)	1	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				GTTATAGTTCCTCAGAAACTG	0.358000												
MLL2	8085	broad.mit.edu	37	12	49424062	49424062	+	Splice_Site	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr12:49424062C>T	uc001rta.3	-	42	13999	c.13999_splice	c.e42+1	p.D4667_splice		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2						chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCTTGACTTACCCCTCAGTGC	0.547000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)		
C12orf44	60673	broad.mit.edu	37	12	52470726	52470726	+	Silent	SNP	C	C	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr12:52470726C>A	uc001rzu.3	+	4	884	c.409C>A	c.(409-411)CGG>AGG	p.R137R	C12orf44_uc009zmd.2_Silent_p.R137R|uc009zme.1_5'Flank	NM_021934	NP_068753	Q9BSB4	ATGA1_HUMAN	Atg13-interacting protein	137					autophagic vacuole assembly	pre-autophagosomal structure	identical protein binding|protein complex binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0978)		GGAGCAGGAGCGGCAGATCTG	0.567000												
RBMS2	5939	broad.mit.edu	37	12	56975886	56975886	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr12:56975886G>A	uc001sln.2	+	9	1022	c.823G>A	c.(823-825)GCT>ACT	p.A275T	RBMS2_uc010sqp.1_Missense_Mutation_p.A130T|RBMS2_uc010sqq.1_Missense_Mutation_p.A150T|RBMS2_uc009zou.2_Missense_Mutation_p.A32T	NM_002898	NP_002889	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting	275					RNA processing	nucleus	nucleotide binding|RNA binding				0						CAGGATGCTTGCTCAGTCTGC	0.502000												
ALX1	8092	broad.mit.edu	37	12	85677378	85677378	+	Silent	SNP	A	A	G			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr12:85677378A>G	uc001tae.3	+	2	259	c.255A>G	c.(253-255)GGA>GGG	p.G85G		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	85					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		AAGTAGAAGGACAGCCCCTTC	0.438000												
CCDC122	160857	broad.mit.edu	37	13	44433927	44433927	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr13:44433927A>G	uc010acf.2	-	5	695	c.436T>C	c.(436-438)TGG>CGG	p.W146R	CCDC122_uc010tfn.1_Missense_Mutation_p.W146R	NM_144974	NP_659411	Q5T0U0	CC122_HUMAN	coiled-coil domain containing 122	146											0		Lung NSC(96;7.5e-06)|Breast(139;0.00765)|Hepatocellular(98;0.00826)|Prostate(109;0.0143)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000767)|BRCA - Breast invasive adenocarcinoma(63;0.128)		ATAAATGACCATTTGCTCTCT	0.318000												
NID2	22795	broad.mit.edu	37	14	52508986	52508986	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr14:52508986C>T	uc001wzo.2	-	7	1896	c.1662G>A	c.(1660-1662)CTG>CTA	p.L554L	NID2_uc010tqs.1_Silent_p.L554L|NID2_uc010tqt.1_Silent_p.L554L|NID2_uc001wzp.2_Silent_p.L554L	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	554	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TATACGCATGCAGGTCCACAT	0.587000												
MTHFD1	4522	broad.mit.edu	37	14	64894054	64894054	+	Splice_Site	SNP	G	G	C			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr14:64894054G>C	uc001xhb.2	+	12	1515	c.1128_splice	c.e12-1	p.G376_splice	MTHFD1_uc010aqe.2_Splice_Site_p.G412_splice|MTHFD1_uc010aqf.2_Splice_Site_p.G432_splice	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1						folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCGTCTTGAAGAATAACTCCA	0.423000												
CYP19A1	1588	broad.mit.edu	37	15	51503068	51503068	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr15:51503068C>T	uc001zyz.3	-	11	1700	c.1449G>A	c.(1447-1449)GAG>GAA	p.E483E	CYP19A1_uc001zza.3_Silent_p.E483E	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	483					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	TGTTTTTAGTCTCATCTGGGT	0.463000												
ISLR	3671	broad.mit.edu	37	15	74467619	74467619	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr15:74467619C>T	uc002axg.1	+	2	702	c.420C>T	c.(418-420)GAC>GAT	p.D140D	ISLR_uc002axh.1_Silent_p.D140D	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	140	LRR 4.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TCCCCCGCGACGCCTTCCGCA	0.612000												
AXIN1	8312	broad.mit.edu	37	16	339583	339583	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr16:339583G>A	uc002cgp.1	-	10	2496	c.2319C>T	c.(2317-2319)GGC>GGT	p.G773G	AXIN1_uc002cgq.1_Silent_p.G737G	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	773	Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CACTCCCGCCGCCCACCTTCC	0.647000												
C16orf73	254528	broad.mit.edu	37	16	1891975	1891975	+	Splice_Site	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr16:1891975C>T	uc002cne.2	-	11	999	c.881_splice	c.e11-1	p.L294_splice	C16orf73_uc010uvq.1_Splice_Site_p.L294_splice|C16orf73_uc010uvr.1_Splice_Site_p.L87_splice	NM_152764	NP_689977	Q8N635	CP073_HUMAN	hypothetical protein LOC254528 isoform 2						meiosis	cytoplasm					0						ATTGTACTTACTAAAAACAGA	0.328000												
ITPRIPL2	162073	broad.mit.edu	37	16	19126204	19126204	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr16:19126204G>A	uc002dfu.3	+	1	951	c.421G>A	c.(421-423)GGT>AGT	p.G141S	ITPRIPL2_uc002dft.2_5'UTR	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	141	Cytoplasmic (Potential).					integral to membrane				skin(2)	2						GGGGTCCCCCGGTCTCATTCC	0.692000												
TUFM	7284	broad.mit.edu	37	16	28855126	28855126	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr16:28855126G>A	uc002drh.2	-	9	1264	c.1125C>T	c.(1123-1125)TCC>TCT	p.S375S	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	372						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1						GCATGAAGTGGGACACAAAGG	0.587000												
HYDIN	54768	broad.mit.edu	37	16	70908761	70908761	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr16:70908761G>A	uc002ezr.2	-	63	10744	c.10616C>T	c.(10615-10617)GCG>GTG	p.A3539V		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3540										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GTAGATATACGCGGTGGTGGG	0.507000												
FA2H	79152	broad.mit.edu	37	16	74750315	74750315	+	Silent	SNP	C	C	A	rs144071567	byFrequency	TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr16:74750315C>A	uc002fde.1	-	6	1037	c.969G>T	c.(967-969)CCG>CCT	p.P323P	FA2H_uc002fdd.1_Silent_p.P96P|FA2H_uc010vmy.1_RNA	NM_024306	NP_077282	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	323					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity				0						AGCCCTTGTGCGGCGAGCCAA	0.607000												
OVCA2	124641	broad.mit.edu	37	17	1945948	1945948	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr17:1945948G>A	uc002ftx.2	+	2	299	c.234G>A	c.(232-234)CAG>CAA	p.Q78Q	DPH1_uc002ftr.1_Intron|DPH1_uc002fts.2_3'UTR|DPH1_uc002ftt.2_3'UTR|DPH1_uc010cjx.2_3'UTR|DPH1_uc010vqs.1_3'UTR|DPH1_uc002ftu.2_3'UTR|DPH1_uc002ftv.2_3'UTR|DPH1_uc002ftw.2_3'UTR	NM_080822	NP_543012	Q8WZ82	OVCA2_HUMAN	candidate tumor suppressor in ovarian cancer 2	78					response to retinoic acid	cytoplasm	hydrolase activity				0						TTTCAGAGCAGGAGGCCGACG	0.617000											OREG0024078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
ZMYND15	84225	broad.mit.edu	37	17	4646694	4646694	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr17:4646694C>T	uc002fyt.2	+	6	1280	c.1241C>T	c.(1240-1242)CCG>CTG	p.P414L	ZMYND15_uc002fyv.2_Missense_Mutation_p.P414L|ZMYND15_uc002fyu.2_Missense_Mutation_p.P414L	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2	414							zinc ion binding				0						ATTCCAGGCCCGGGCTTCTCC	0.632000												
MYH4	4622	broad.mit.edu	37	17	10362660	10362660	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr17:10362660G>A	uc002gmn.2	-	15	1606	c.1495C>T	c.(1495-1497)CTG>TTG	p.L499L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	499	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCCTGCTCCAGCACGAACATG	0.478000												
FBXW10	10517	broad.mit.edu	37	17	18675802	18675802	+	Missense_Mutation	SNP	C	C	T	rs150329747	byFrequency	TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr17:18675802C>T	uc002guk.2	+	12	2316	c.2084C>T	c.(2083-2085)ACG>ATG	p.T695M	FBXW10_uc002guj.2_Missense_Mutation_p.T695M|FBXW10_uc002gul.2_Missense_Mutation_p.T724M|FBXW10_uc010cqh.1_Missense_Mutation_p.T642M	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	695	Potential.									ovary(1)	1						GTggaaaaaacgaaacaaaag	0.328000												
SLC4A1	6521	broad.mit.edu	37	17	42338119	42338119	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr17:42338119G>A	uc002igf.3	-	5	382	c.233C>T	c.(232-234)GCG>GTG	p.A78V	SLC4A1_uc002igg.3_Missense_Mutation_p.A78V	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	78	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CCAGCGCGCCGCCTCCATCCA	0.622000												
DGKE	8526	broad.mit.edu	37	17	54912541	54912541	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr17:54912541C>T	uc002iur.2	+	2	565	c.385C>T	c.(385-387)CGG>TGG	p.R129W	DGKE_uc002ius.1_Missense_Mutation_p.R129W|C17orf67_uc002iuq.2_5'Flank	NM_003647	NP_003638	P52429	DGKE_HUMAN	diacylglycerol kinase epsilon	129	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(2)	2	Breast(9;3.59e-07)					CCACTGGATCCGGGGCAACGT	0.567000												
BAHCC1	57597	broad.mit.edu	37	17	79428363	79428363	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr17:79428363C>T	uc002kaf.2	+	24	6674	c.6674C>T	c.(6673-6675)GCG>GTG	p.A2225V	BAHCC1_uc002kae.2_Missense_Mutation_p.A1455V	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	2225							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			ACCTGCAAGGCGTTGCTCATG	0.677000												
EPB41L3	23136	broad.mit.edu	37	18	5398077	5398077	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr18:5398077C>T	uc002kmt.1	-	17	2501	c.2415G>A	c.(2413-2415)GCG>GCA	p.A805A	EPB41L3_uc010wzh.1_Silent_p.A636A|EPB41L3_uc002kmu.1_Intron|EPB41L3_uc010dkq.1_Intron|EPB41L3_uc002kms.1_Intron|EPB41L3_uc010wze.1_Silent_p.A110A|EPB41L3_uc010wzf.1_Silent_p.A102A|EPB41L3_uc010wzg.1_Silent_p.A77A|EPB41L3_uc010dkr.2_Silent_p.A197A	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	805	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TTGGTTTTCGCGCAGACTCTA	0.448000												
PIGN	23556	broad.mit.edu	37	18	59777079	59777079	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr18:59777079G>A	uc002lii.3	-	18	2010	c.1562C>T	c.(1561-1563)GCG>GTG	p.A521V	PIGN_uc002lij.3_Missense_Mutation_p.A521V	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	521	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				TCTTAGAACCGCATACCATAT	0.358000												
CYP4F2	8529	broad.mit.edu	37	19	15989736	15989736	+	Missense_Mutation	SNP	C	C	T	rs146148233		TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr19:15989736C>T	uc002nbs.1	-	13	1458	c.1408G>A	c.(1408-1410)GGG>AGG	p.G470R	CYP4F2_uc010xot.1_Missense_Mutation_p.G321R	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	470					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						AACGTCTGCCCGATGCAGTTC	0.672000												
LSM4	25804	broad.mit.edu	37	19	18420552	18420552	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr19:18420552G>A	uc002niq.2	-	4	435	c.264C>T	c.(262-264)CGC>CGT	p.R88R		NM_012321	NP_036453	Q9Y4Z0	LSM4_HUMAN	U6 snRNA-associated Sm-like protein 4	88					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|mRNA processing|RNA splicing	cytosol|U6 snRNP	protein binding|RNA binding				0						CTCCGCGGCCGCGGCCCTTGG	0.682000												
MED29	55588	broad.mit.edu	37	19	39882040	39882040	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr19:39882040T>C	uc002olf.2	+	1	78	c.41T>C	c.(40-42)CTT>CCT	p.L14P	PAF1_uc002old.2_5'Flank|PAF1_uc002ole.1_5'Flank|PAF1_uc010xuv.1_5'Flank|MED29_uc010xuw.1_Missense_Mutation_p.L14P|MED29_uc010xux.1_RNA	NM_017592	NP_060062	Q9NX70	MED29_HUMAN	mediator complex subunit 29	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	protein binding			ovary(1)|pancreas(1)	2	all_cancers(60;7.82e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;1.04e-26)|all cancers(26;7.68e-24)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CGTAACGCACTTCCGGCGGTC	0.587000												
PHLDB3	653583	broad.mit.edu	37	19	43990419	43990419	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr19:43990419G>A	uc002own.3	-	13	1743	c.1484C>T	c.(1483-1485)ACG>ATG	p.T495M	PHLDB3_uc010eit.2_Missense_Mutation_p.T199M	NM_198850	NP_942147	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B,	495											0		Prostate(69;0.0153)				GGGACTGACCGTGATGGCAGG	0.567000												
LIN7B	64130	broad.mit.edu	37	19	49619588	49619588	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr19:49619588G>A	uc002pmp.2	+	4	341	c.297G>A	c.(295-297)ACG>ACA	p.T99T		NM_022165	NP_071448	Q9HAP6	LIN7B_HUMAN	lin-7 homolog B	99	PDZ.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein domain specific binding				0		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;5e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000191)|GBM - Glioblastoma multiforme(486;0.00449)|Epithelial(262;0.01)		TACCCAAGACGGATGAGGGCC	0.607000												
ZNF610	162963	broad.mit.edu	37	19	52857558	52857558	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr19:52857558C>T	uc002pyx.3	+	5	651	c.245C>T	c.(244-246)CCC>CTC	p.P82L	ZNF610_uc002pyy.3_Missense_Mutation_p.P82L|ZNF610_uc002pyz.3_Intron|ZNF610_uc002pza.2_Missense_Mutation_p.P82L	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	82	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AGGAGAGAGCCCTTGATTCTG	0.398000												
PPP1R12C	54776	broad.mit.edu	37	19	55606106	55606106	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr19:55606106C>T	uc002qix.2	-	12	1531	c.1515G>A	c.(1513-1515)CCG>CCA	p.P505P	PPP1R12C_uc010yfs.1_Silent_p.P431P|PPP1R12C_uc002qiy.2_Silent_p.P504P	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	505	Pro-rich.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		ATTCAGGCTCCGGAATCCTGG	0.552000												
PXDN	7837	broad.mit.edu	37	2	1653281	1653281	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:1653281G>A	uc002qxa.2	-	17	2335	c.2271C>T	c.(2269-2271)GGC>GGT	p.G757G		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	757					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCAGCGAGGCGCCCCACATGG	0.637000												
GREB1	9687	broad.mit.edu	37	2	11750964	11750964	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:11750964G>A	uc002rbk.1	+	18	3117	c.2817G>A	c.(2815-2817)CCG>CCA	p.P939P	GREB1_uc002rbo.1_Silent_p.P573P|GREB1_uc002rbp.1_5'Flank	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	939						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TCAACTCCCCGAAGCAGTGCC	0.687000												
ACTG2	72	broad.mit.edu	37	2	74143812	74143812	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:74143812G>A	uc002sjw.2	+	8	1029	c.907G>A	c.(907-909)GGC>AGC	p.G303S	ACTG2_uc010fey.2_Missense_Mutation_p.G303S|ACTG2_uc010yrn.1_Missense_Mutation_p.G260S	NM_001615	NP_001606	P63267	ACTH_HUMAN	actin, gamma 2 propeptide	303					muscle contraction	cytoskeleton|cytosol	ATP binding				0						CCTCTCTGGGGGCACCACCAT	0.512000												
CTNNA2	1496	broad.mit.edu	37	2	79878715	79878715	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:79878715A>T	uc010ysh.1	+	1	38	c.33A>T	c.(31-33)AAA>AAT	p.K11N	CTNNA2_uc010yse.1_Missense_Mutation_p.K11N|CTNNA2_uc010ysf.1_Missense_Mutation_p.K11N|CTNNA2_uc010ysg.1_Missense_Mutation_p.K11N|hsa-mir-4264|MI0015877_5'Flank	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	11					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TCATTCTGAAATGGGACCCCA	0.403000												
PSD4	23550	broad.mit.edu	37	2	113940394	113940394	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:113940394G>T	uc002tjc.2	+	2	544	c.361G>T	c.(361-363)GCC>TCC	p.A121S	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.A120S|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	121					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GAGCCCCTCTGCCCAGAGGGA	0.627000												
WDSUB1	151525	broad.mit.edu	37	2	160132102	160132102	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:160132102C>A	uc002uaj.3	-	4	780	c.631G>T	c.(631-633)GAT>TAT	p.D211Y	WDSUB1_uc002uak.3_Missense_Mutation_p.D211Y|WDSUB1_uc002ual.3_Missense_Mutation_p.D211Y|WDSUB1_uc002uam.3_Missense_Mutation_p.D211Y|WDSUB1_uc010foo.2_Missense_Mutation_p.D211Y	NM_152528	NP_689741	Q8N9V3	WSDU1_HUMAN	WD repeat, sterile alpha motif and U-box domain	211	WD 5.					ubiquitin ligase complex	ubiquitin-protein ligase activity				0						ACTTGGCAATCCTGACCACAT	0.333000												
MYO3B	140469	broad.mit.edu	37	2	171371472	171371472	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:171371472G>A	uc002ufy.2	+	29	3555	c.3412G>A	c.(3412-3414)GCA>ACA	p.A1138T	MYO3B_uc002ufv.2_Missense_Mutation_p.A1125T|MYO3B_uc010fqb.1_Missense_Mutation_p.A1125T|MYO3B_uc002ufz.2_Missense_Mutation_p.A1111T|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	1138					response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						TTCCCCCGTCGCAGCAGGTAC	0.478000												
TTN	7273	broad.mit.edu	37	2	179454415	179454415	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:179454415A>T	uc010zfg.1	-	253	54557	c.54333T>A	c.(54331-54333)GAT>GAA	p.D18111E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D11806E|TTN_uc010zfi.1_Missense_Mutation_p.D11739E|TTN_uc010zfj.1_Missense_Mutation_p.D11614E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19038							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTTCCTTTATCTGCAATGT	0.448000												
ZDBF2	57683	broad.mit.edu	37	2	207172945	207172945	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:207172945G>A	uc002vbp.2	+	5	3943	c.3693G>A	c.(3691-3693)ACG>ACA	p.T1231T		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1231							nucleic acid binding|zinc ion binding			ovary(3)	3						AAGTTGACACGGAAGATAGGA	0.423000												
C2orf57	165100	broad.mit.edu	37	2	232458738	232458738	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:232458738G>A	uc002vrz.2	+	1	1127	c.1076G>A	c.(1075-1077)CGT>CAT	p.R359H		NM_152614	NP_689827	Q53QW1	CB057_HUMAN	hypothetical protein LOC165100	359										ovary(1)	1		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		ACCATCACCCGTGTGCTGGAG	0.687000												
GPR35	2859	broad.mit.edu	37	2	241569891	241569891	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr2:241569891G>A	uc002vzs.1	+	1	1097	c.522G>A	c.(520-522)GCG>GCA	p.A174A	GPR35_uc010fzh.1_Silent_p.A205A|GPR35_uc010fzi.1_Silent_p.A205A	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	174	Extracellular (Potential).			A -> R (in Ref. 1; AAC52028).		integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		ACTCCATGGCGTTCCCGCTGC	0.662000												
BPI	671	broad.mit.edu	37	20	36932707	36932707	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr20:36932707G>A	uc002xib.2	+	1	156	c.94G>A	c.(94-96)GTC>ATC	p.V32I		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	32					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				GACAGCGGCCGTCAACCCTGG	0.607000												
ARFGEF2	10564	broad.mit.edu	37	20	47589805	47589805	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr20:47589805G>A	uc002xtx.3	+	12	1801	c.1649G>A	c.(1648-1650)GGA>GAA	p.G550E		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	550					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CATGAGCTGGGAATGACACCT	0.289000												
CLDN14	23562	broad.mit.edu	37	21	37833744	37833744	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr21:37833744T>C	uc002yvk.1	-	2	392	c.250A>G	c.(250-252)ATG>GTG	p.M84V	CLDN14_uc002yvn.1_Missense_Mutation_p.M84V|CLDN14_uc002yvo.1_Missense_Mutation_p.M84V|CLDN14_uc002yvl.1_Missense_Mutation_p.M84V|CLDN14_uc002yvm.1_Missense_Mutation_p.M84V	NM_012130	NP_036262	O95500	CLD14_HUMAN	claudin 14	84	Helical; (Potential).				calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GAGATGACCATGAGGGCGCGG	0.652000												
LSS	4047	broad.mit.edu	37	21	47636354	47636354	+	Silent	SNP	G	G	A	rs138974013		TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr21:47636354G>A	uc002zij.2	-	7	811	c.732C>T	c.(730-732)TAC>TAT	p.Y244Y	LSS_uc011afv.1_Silent_p.Y233Y|LSS_uc002zil.2_Silent_p.Y244Y|LSS_uc002zik.2_Silent_p.Y164Y	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	244					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					GCCGAACGGCGTAGCAGTAGC	0.652000												
POLR2F	5435	broad.mit.edu	37	22	38352790	38352790	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr22:38352790G>A	uc003aul.2	+	2	152	c.31G>A	c.(31-33)GAC>AAC	p.D11N	POLR2F_uc010gxi.2_5'UTR|POLR2F_uc003aum.2_RNA	NM_021974	NP_068809	P61218	RPAB2_HUMAN	DNA directed RNA polymerase II polypeptide F	11					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)	1	Melanoma(58;0.045)					TTTTGATGGCGACGACTTTGA	0.398000												
C22orf40	150383	broad.mit.edu	37	22	46640993	46640993	+	Missense_Mutation	SNP	G	G	A	rs151250954		TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr22:46640993G>A	uc003bhe.2	-	4	409	c.368C>T	c.(367-369)ACG>ATG	p.T123M	C22orf40_uc003bhc.2_3'UTR|C22orf40_uc003bhd.2_Missense_Mutation_p.T118M|C22orf40_uc003bhf.2_RNA	NM_207327	NP_997210	Q6NVV7	CV040_HUMAN	hypothetical protein LOC150383	123											0						TTGCACTCACGTCCGAGAACC	0.612000												
TUBGCP6	85378	broad.mit.edu	37	22	50682244	50682244	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr22:50682244G>A	uc003bkb.1	-	1	1157	c.645C>T	c.(643-645)TTC>TTT	p.F215F	TUBGCP6_uc010har.1_Silent_p.F215F|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hau.1_Silent_p.F215F	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	215					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CAAGGGCCCCGAAGAGCGAGA	0.627000												
GOLGA4	2803	broad.mit.edu	37	3	37365781	37365781	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr3:37365781G>A	uc003cgv.2	+	14	2708	c.2404G>A	c.(2404-2406)GTT>ATT	p.V802I	GOLGA4_uc010hgr.1_Missense_Mutation_p.V363I|GOLGA4_uc003cgw.2_Missense_Mutation_p.V824I|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.V683I	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	802	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TAAGCTGGACGTTTTTCAGTC	0.443000												
SLC38A3	10991	broad.mit.edu	37	3	50254855	50254855	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr3:50254855G>A	uc003cyn.3	+	9	781	c.640G>A	c.(640-642)GGC>AGC	p.G214S	SLC38A3_uc011bdl.1_Missense_Mutation_p.G189S|SLC38A3_uc011bdm.1_Missense_Mutation_p.G145S	NM_006841	NP_006832	Q99624	S38A3_HUMAN	solute carrier family 38, member 3	214	Helical; (Potential).				cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	AGGCTACCTGGGCTACTCCAG	0.592000												
DNAH1	25981	broad.mit.edu	37	3	52380535	52380535	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr3:52380535C>T	uc011bef.1	+	11	1965	c.1704C>T	c.(1702-1704)GCC>GCT	p.A568A	DNAH1_uc003ddt.1_Silent_p.A568A	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	568	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TAAAGGTGGCCATGCGCAGCA	0.582000												
DNAH1	25981	broad.mit.edu	37	3	52417495	52417495	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr3:52417495G>A	uc011bef.1	+	51	8296	c.8035G>A	c.(8035-8037)GTC>ATC	p.V2679I	DNAH1_uc003ddv.2_5'Flank	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2679	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGACCAGATCGTCAGCACCAT	0.542000												
DNAH1	25981	broad.mit.edu	37	3	52426895	52426895	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr3:52426895G>A	uc011bef.1	+	65	10589	c.10328G>A	c.(10327-10329)CGC>CAC	p.R3443H	DNAH1_uc003ddv.2_Missense_Mutation_p.R301H	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3508					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GACCTGACGCGCATGGAGTAC	0.592000												
NCK1	4690	broad.mit.edu	37	3	136664893	136664893	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr3:136664893G>A	uc003erh.2	+	3	802	c.695G>A	c.(694-696)TGC>TAC	p.C232Y	NCK1_uc011bme.1_Missense_Mutation_p.C168Y	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	232	SH3 3.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						TGGTGGAAATGCAGGAAGATC	0.383000												
ZBTB38	253461	broad.mit.edu	37	3	141164795	141164795	+	Missense_Mutation	SNP	G	G	A	rs76129297		TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr3:141164795G>A	uc003etw.2	+	8	4547	c.3565G>A	c.(3565-3567)GGT>AGT	p.G1189S	ZBTB38_uc010hun.2_Missense_Mutation_p.G1186S|ZBTB38_uc010huo.2_Missense_Mutation_p.G1189S|ZBTB38_uc003ety.2_Missense_Mutation_p.G1189S|ZBTB38_uc010hup.2_Missense_Mutation_p.G1190S	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	1189					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CATACAAACCGGTGTGGAAAA	0.343000												
PIK3CA	5290	broad.mit.edu	37	3	178927980	178927980	+	Missense_Mutation	SNP	T	T	C	rs121913272		TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr3:178927980T>C	uc003fjk.2	+	8	1415	c.1258T>C	c.(1258-1260)TGT>CGT	p.C420R		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	420	C2 PI3K-type.		C -> R (in cancer; shows an increase in lipid kinase activity; may increase the affinity for lipid membranes).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.C420R(26)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TAAGGAACACTGTCCATTGGC	0.328000	C420R(EFM192A_BREAST)|C420R(OVISE_OVARY)|C420R(HEC151_ENDOMETRIUM)|C420R(CCK81_LARGE_INTESTINE)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)		
KCTD8	386617	broad.mit.edu	37	4	44449880	44449880	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr4:44449880G>A	uc003gwu.2	-	1	945	c.661C>T	c.(661-663)CGC>TGC	p.R221C		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	221						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TGGTTGTCGCGCACGGTGGTG	0.542000										HNSCC(17;0.042)		
C4orf33	132321	broad.mit.edu	37	4	130030790	130030790	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr4:130030790C>G	uc003igu.3	+	5	821	c.457C>G	c.(457-459)CCT>GCT	p.P153A	C4orf33_uc010ioc.1_Missense_Mutation_p.P153A|C4orf33_uc010iod.2_Missense_Mutation_p.P153A	NM_173487	NP_775758	Q8N1A6	CD033_HUMAN	hypothetical protein LOC132321	153										upper_aerodigestive_tract(1)	1						TTACCCTGTACCTCAGCATGA	0.333000												
NR3C2	4306	broad.mit.edu	37	4	149041319	149041319	+	Silent	SNP	T	T	C			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr4:149041319T>C	uc003ilj.3	-	7	2965	c.2631A>G	c.(2629-2631)CTA>CTG	p.L877L	NR3C2_uc003ilk.3_Silent_p.L760L|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	877	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	TTGTGCTTAGTAGCAGCAAAA	0.428000												
FYB	2533	broad.mit.edu	37	5	39202557	39202557	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:39202557G>A	uc003jls.2	-	1	573	c.506C>T	c.(505-507)GCG>GTG	p.A169V	FYB_uc003jlt.2_Missense_Mutation_p.A169V|FYB_uc003jlu.2_Missense_Mutation_p.A169V|FYB_uc011cpl.1_Missense_Mutation_p.A179V	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	169					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TTTGGGAAACGCTTGCTTCTG	0.488000												
POU5F2	134187	broad.mit.edu	37	5	93077167	93077167	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:93077167A>C	uc003kkl.1	-	1	143	c.103T>G	c.(103-105)TTG>GTG	p.L35V	FAM172A_uc010jbd.2_Intron|FAM172A_uc011cuf.1_Intron|FAM172A_uc011cug.1_Intron|FAM172A_uc011cuh.1_Intron|FAM172A_uc011cui.1_Intron|FAM172A_uc011cuj.1_Intron	NM_153216	NP_694948	Q8N7G0	PO5F2_HUMAN	POU domain class 5, transcription factor 2	35						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(142;3.87e-05)|all_epithelial(76;4.59e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0415)|all cancers(79;2.03e-19)		TGGGTGCTCAACCAGGTCAGA	0.697000												
YTHDC2	64848	broad.mit.edu	37	5	112888990	112888990	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:112888990G>A	uc003kqn.2	+	13	1984	c.1801G>A	c.(1801-1803)GAT>AAT	p.D601N	YTHDC2_uc010jce.1_Missense_Mutation_p.D601N|YTHDC2_uc010jcf.1_Missense_Mutation_p.D301N	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	601							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TAGTTTCGATGATGAAAAAGT	0.373000												
P4HA2	8974	broad.mit.edu	37	5	131552925	131552925	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:131552925G>A	uc003kwh.2	-	4	860	c.296C>T	c.(295-297)GCG>GTG	p.A99V	P4HA2_uc003kwg.2_Missense_Mutation_p.A99V|P4HA2_uc003kwi.2_Missense_Mutation_p.A99V|P4HA2_uc003kwk.2_Missense_Mutation_p.A99V|P4HA2_uc003kwl.2_Missense_Mutation_p.A99V|P4HA2_uc003kwj.2_Missense_Mutation_p.A99V	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	99						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	GTCCTCCAGCGCAGGCCAGTC	0.567000												
BRD8	10902	broad.mit.edu	37	5	137475855	137475855	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:137475855C>T	uc003lcf.1	-	27	3671	c.3616G>A	c.(3616-3618)GTA>ATA	p.V1206I	BRD8_uc003lcc.1_Intron|NME5_uc003lce.2_5'Flank	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1206					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATATTCAGTACCTAAAGGGTT	0.368000												
PCDHB8	56128	broad.mit.edu	37	5	140559781	140559781	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:140559781G>A	uc011dai.1	+	1	2352	c.2166G>A	c.(2164-2166)TCG>TCA	p.S722S	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	722	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCGGCCTCGGTGGGTCGCT	0.642000												
SH3RF2	153769	broad.mit.edu	37	5	145317619	145317619	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:145317619C>T	uc003lnt.2	+	2	366	c.128C>T	c.(127-129)GCC>GTC	p.A43V	SH3RF2_uc011dbl.1_Missense_Mutation_p.A43V	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	43	RING-type.						ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTTTTCAAGGCCCACAAAGAG	0.577000												
PCYOX1L	78991	broad.mit.edu	37	5	148748009	148748009	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:148748009C>T	uc003lqk.2	+	6	1339	c.1277C>T	c.(1276-1278)CCC>CTC	p.P426L	PCYOX1L_uc003lql.2_Missense_Mutation_p.P409L|PCYOX1L_uc010jgz.2_Missense_Mutation_p.P350L|PCYOX1L_uc003lqm.2_Missense_Mutation_p.P308L|PCYOX1L_uc003lqn.2_Missense_Mutation_p.P336L	NM_024028	NP_076933	Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like precursor	426					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGCCCATCCCCTCTATGGC	0.612000												
EBF1	1879	broad.mit.edu	37	5	158158138	158158138	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr5:158158138C>T	uc010jip.2	-	11	1366	c.1064G>A	c.(1063-1065)GGT>GAT	p.G355D	EBF1_uc011ddw.1_Missense_Mutation_p.G223D|EBF1_uc011ddx.1_Missense_Mutation_p.G356D|EBF1_uc003lxl.3_Missense_Mutation_p.G324D	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	355					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTCTGGAAACCATAATCGAT	0.433000			T	HMGA2	lipoma							
PKHD1	5314	broad.mit.edu	37	6	51512896	51512896	+	Silent	SNP	C	C	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr6:51512896C>A	uc003pah.1	-	63	11607	c.11331G>T	c.(11329-11331)CTG>CTT	p.L3777L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3777	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AAGGAGGTCCCAGGGACTCTA	0.418000												
COL12A1	1303	broad.mit.edu	37	6	75893230	75893230	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr6:75893230C>T	uc003phs.2	-	10	1593	c.1427G>A	c.(1426-1428)AGG>AAG	p.R476K	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Missense_Mutation_p.R134K	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	476	VWFA 2.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						AATCTGGACCCTATTTGGTGA	0.353000												
SLC35D3	340146	broad.mit.edu	37	6	137245222	137245222	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr6:137245222C>T	uc003qhe.2	+	2	804	c.639C>T	c.(637-639)CAC>CAT	p.H213H		NM_001008783	NP_001008783	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	213					carbohydrate transport	integral to membrane				ovary(1)|central_nervous_system(1)	2	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		ACTCCATCCACGCCTGGACCT	0.657000												
GRM1	2911	broad.mit.edu	37	6	146720544	146720544	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr6:146720544C>T	uc010khw.1	+	8	2839	c.2369C>T	c.(2368-2370)ACC>ATC	p.T790I	GRM1_uc010khv.1_Missense_Mutation_p.T790I|GRM1_uc003qll.2_Missense_Mutation_p.T790I|GRM1_uc011edz.1_Missense_Mutation_p.T790I|GRM1_uc011eea.1_Missense_Mutation_p.T790I	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	790	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATCGCGTTCACCATGTACACC	0.478000												
SYNE1	23345	broad.mit.edu	37	6	152651705	152651705	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr6:152651705G>A	uc010kiw.2	-	78	14717	c.14115C>T	c.(14113-14115)GCC>GCT	p.A4705A	SYNE1_uc003qot.3_Silent_p.A4634A|SYNE1_uc003qou.3_Silent_p.A4705A|SYNE1_uc010kiz.2_Silent_p.A460A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4705	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTCCTCAACGGCCAGGTCGG	0.522000										HNSCC(10;0.0054)		
PDGFA	5154	broad.mit.edu	37	7	552006	552006	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr7:552006G>A	uc003sir.2	-	3	1090	c.247C>T	c.(247-249)CGG>TGG	p.R83W	PDGFA_uc003sis.2_Missense_Mutation_p.R83W|PDGFA_uc003sit.1_Missense_Mutation_p.R97W	NM_002607	NP_002598	P04085	PDGFA_HUMAN	platelet-derived growth factor alpha isoform 1	83					actin cytoskeleton organization|angiogenesis|cell projection assembly|embryo development|hair follicle development|lung alveolus development|negative chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|organ morphogenesis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of DNA replication|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of MAP kinase activity|positive regulation of mesenchymal cell proliferation|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein kinase B signaling cascade|regulation of actin cytoskeleton organization|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|regulation of peptidyl-tyrosine phosphorylation|regulation of smooth muscle cell migration|skin development	cell surface|endoplasmic reticulum lumen|extracellular space|Golgi membrane|microvillus|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity				0		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|Epithelial(4;1.1e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.7e-17)|all cancers(6;4.89e-15)		CTCTTCCTCCGAATGGGCAGG	0.398000												
URGCP	55665	broad.mit.edu	37	7	43917871	43917871	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr7:43917871G>A	uc003tiw.2	-	6	1248	c.1191C>T	c.(1189-1191)AAC>AAT	p.N397N	URGCP_uc003tiu.2_Silent_p.N354N|URGCP_uc003tiv.2_Silent_p.N322N|URGCP_uc003tix.2_Silent_p.N388N|URGCP_uc003tiy.2_Silent_p.N354N|URGCP_uc003tiz.2_Silent_p.N354N|URGCP_uc011kbj.1_Silent_p.N354N	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	397					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						GAAATCTCAGGTTTGTGTTGC	0.438000												
ADCY1	107	broad.mit.edu	37	7	45614571	45614571	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr7:45614571C>T	uc003tne.3	+	1	447	c.429C>T	c.(427-429)GGC>GGT	p.G143G	ADCY1_uc003tnd.2_5'UTR	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	143	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCGCGCTgggcggccccgccc	0.507000												
MUC17	140453	broad.mit.edu	37	7	100678664	100678664	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr7:100678664G>A	uc003uxp.1	+	3	4020	c.3967G>A	c.(3967-3969)GAA>AAA	p.E1323K	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1323	Extracellular (Potential).|20.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACACCTGCTGAAGGTACCAG	0.468000												
MUC17	140453	broad.mit.edu	37	7	100684284	100684284	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr7:100684284C>A	uc003uxp.1	+	3	9640	c.9587C>A	c.(9586-9588)ACC>AAC	p.T3196N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3196	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|52.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACACCTGTGACCACTTCTACT	0.468000												
IFRD1	3475	broad.mit.edu	37	7	112102348	112102348	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr7:112102348T>C	uc003vgh.2	+	9	1264	c.821T>C	c.(820-822)CTC>CCC	p.L274P	IFRD1_uc011kmn.1_Missense_Mutation_p.L224P|IFRD1_uc003vgj.2_Missense_Mutation_p.L274P|IFRD1_uc011kmo.1_RNA|IFRD1_uc011kmp.1_Missense_Mutation_p.L224P	NM_001007245	NP_001007246	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	274					multicellular organismal development|myoblast cell fate determination		binding			kidney(1)|central_nervous_system(1)	2						CTTCCAAGCCTCCTCTCTTGT	0.353000												
FAM180A	389558	broad.mit.edu	37	7	135418743	135418743	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr7:135418743G>T	uc003vtd.2	-	3	768	c.502C>A	c.(502-504)CAG>AAG	p.Q168K	FAM180A_uc010lmt.2_RNA|FAM180A_uc010lmu.2_Missense_Mutation_p.Q168K	NM_205855	NP_995327	Q6UWF9	F180A_HUMAN	hypothetical protein LOC389558 precursor	168						extracellular region				ovary(2)	2						ACTCCCGGCTGTGAGGAGCGC	0.587000												
FAM135B	51059	broad.mit.edu	37	8	139209873	139209873	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr8:139209873C>T	uc003yuy.2	-	8	880	c.709G>A	c.(709-711)GCA>ACA	p.A237T	FAM135B_uc003yux.2_Missense_Mutation_p.A138T|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	237										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CACTTGTGTGCGTGCTGCATG	0.582000										HNSCC(54;0.14)		
PLEC	5339	broad.mit.edu	37	8	144997456	144997456	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr8:144997456G>A	uc003zaf.1	-	31	7222	c.7052C>T	c.(7051-7053)GCG>GTG	p.A2351V	PLEC_uc003zab.1_Missense_Mutation_p.A2214V|PLEC_uc003zac.1_Missense_Mutation_p.A2218V|PLEC_uc003zad.2_Missense_Mutation_p.A2214V|PLEC_uc003zae.1_Missense_Mutation_p.A2182V|PLEC_uc003zag.1_Missense_Mutation_p.A2192V|PLEC_uc003zah.2_Missense_Mutation_p.A2200V|PLEC_uc003zaj.2_Missense_Mutation_p.A2241V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2351	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGTGGCCTCCGCCTTCAGCCG	0.662000												
FAM166B	730112	broad.mit.edu	37	9	35562915	35562915	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr9:35562915G>A	uc010mkr.2	-	3	520	c.449C>T	c.(448-450)CCG>CTG	p.P150L	FAM166B_uc011lov.1_Missense_Mutation_p.P150L|FAM166B_uc011low.1_Missense_Mutation_p.P150L|FAM166B_uc003zwy.2_Missense_Mutation_p.P150L	NM_001164310	NP_001157782	A8MTA8	F166B_HUMAN	hypothetical protein LOC730112 isoform 1	150											0						CTGCCCCTCCGGCTCTGGCAC	0.567000												
PPP3R2	5535	broad.mit.edu	37	9	104356919	104356919	+	Silent	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr9:104356919C>T	uc004bbr.2	-	1	365	c.294G>A	c.(292-294)GCG>GCA	p.A98A	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_RNA	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	95	EF-hand 3.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	AAATGCTGAACGCAAACCTCA	0.537000												
NUP188	23511	broad.mit.edu	37	9	131768031	131768031	+	Silent	SNP	T	T	C			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr9:131768031T>C	uc004bws.1	+	41	4867	c.4845T>C	c.(4843-4845)AAT>AAC	p.N1615N		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1615					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						CCACAGTGAATGTGGCCCTCA	0.502000												
FBXW5	54461	broad.mit.edu	37	9	139835750	139835750	+	Silent	SNP	G	G	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr9:139835750G>A	uc004cjx.2	-	8	1561	c.1410C>T	c.(1408-1410)GAC>GAT	p.D470D	FBXW5_uc010nbx.2_RNA|FBXW5_uc004cjy.2_Silent_p.D218D|FBXW5_uc004cjz.2_Silent_p.D200D	NM_018998	NP_061871	Q969U6	FBXW5_HUMAN	F-box and WD repeat domain containing 5	470	WD 2.						catalytic activity|protein binding				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		AGAAGCACTCGTCGTTGGGCG	0.682000												
C9orf140	89958	broad.mit.edu	37	9	139960781	139960781	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr9:139960781C>T	uc011men.1	-	2	733	c.617G>A	c.(616-618)CGG>CAG	p.R206Q		NM_178448	NP_848543	Q86UD0	CI140_HUMAN	tumor specificity and mitosis phase-dependent	206						cytoplasm|nucleus				skin(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;3.02e-05)|Epithelial(140;0.000499)		GGGAGCCCGCCGGGCATCCCC	0.711000												
BCOR	54880	broad.mit.edu	37	X	39931763	39931763	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chrX:39931763C>A	uc004den.3	-	4	3128	c.2836G>T	c.(2836-2838)GAG>TAG	p.E946*	BCOR_uc004dep.3_Nonsense_Mutation_p.E946*|BCOR_uc004deo.3_Nonsense_Mutation_p.E946*|BCOR_uc004dem.3_Nonsense_Mutation_p.E946*|BCOR_uc004deq.3_Nonsense_Mutation_p.E946*	NM_001123385	NP_001116857	Q6W2J9	BCOR_HUMAN	BCL-6 interacting corepressor isoform c	946					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						GATTCAGCCTCATCAGCTCCA	0.488000												
CNKSR2	22866	broad.mit.edu	37	X	21627677	21627678	+	In_Frame_Ins	INS	-	-	GAG			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chrX:21627677_21627678insGAG	uc004czx.1	+	20	2670_2671	c.2634_2635insGAG	c.(2632-2637)insGAG	p.886_887insE	CNKSR2_uc004czw.2_In_Frame_Ins_p.886_887insE|CNKSR2_uc011mjn.1_In_Frame_Ins_p.837_838insE|CNKSR2_uc011mjo.1_In_Frame_Ins_p.856_857insE|CNKSR2_uc004czy.2_In_Frame_Ins_p.478_479insE	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	886_887	Potential.|Poly-Glu.				regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						aggtggaggaagaggaggagga	0.376												
ARID2	196528	broad.mit.edu	37	12	46298723	46298724	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chr12:46298722_46298723TAA>T	uc001ros.1	+	20	5369_5370	c.5369_5370TAA>T	c.(5368-5370)ttafs	p.L1790fs	ARID2_uc009zkg.1_Frame_Shift_Del_p.L1246fs|ARID2_uc009zkh.1_Frame_Shift_Del_p.L1417fs|ARID2_uc001rou.1_3'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	Homo sapiens AT rich interactive domain 2 (ARID, RFX-like) (ARID2), mRNA.	1790					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TGCAGATTGTTAAAGAGACATG	0.337			"""N, S, F"""		hepatocellular carcinoma							
CNKSR2	22866	broad.mit.edu	37	X	21627678	21627679	+	In_Frame_Ins	INS	-	-	GAG			TCGA-BR-6455-01A-11D-1800-08	TCGA-BR-6455-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bf3beb5-f999-4822-a0af-ec36f9510d58	db67ce76-e686-4298-a5c1-59638619e250	g.chrX:21627677_21627678A>AGAG	uc004czx.2	+	19	3114_3115	c.2634_2635A>AGAG	c.(2632-2637)gaagag>gaAGAGag	p.878_879EE>EE	CNKSR2_uc004czw.3_In_Frame_Ins_p.878_879EE>EE|CNKSR2_uc011mjn.2_In_Frame_Ins_p.829_830EE>EE|CNKSR2_uc011mjo.2_In_Frame_Ins_p.848_849EE>EE|CNKSR2_uc004czy.3_In_Frame_Ins_p.470_471EE>EE	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	Homo sapiens connector enhancer of kinase suppressor of Ras 2 (CNKSR2), transcript variant 1, mRNA.	878	Poly-Glu.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						aggtggaggaagaggaggagga	0.515