Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
MORN1	79906	broad.mit.edu	37	1	2303936	2303936	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:2303936G>A	uc001ajb.1	-	8	750	c.729C>T	c.(727-729)CAC>CAT	p.H243H	MORN1_uc009vld.2_Silent_p.H219H|MORN1_uc001ajd.1_Silent_p.H243H	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	MORN repeat containing 1	243										ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		CAATTTCCCCGTGGTCCTGCA	0.542												
RER1	11079	broad.mit.edu	37	1	2334500	2334500	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:2334500G>A	uc001aje.1	+	7	719	c.528G>A	c.(526-528)CCG>CCA	p.P176P	RER1_uc001ajf.1_3'UTR	NM_007033	NP_008964	O15258	RER1_HUMAN	RER1 retention in endoplasmic reticulum 1	176				HAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMK RQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS -> DASV CGDGRCSCKAGGGRQCPVLAADAALTFSPHLKACGYQGHPC GYGLYFLRRFQRPGVLADSGDVLHHALLYHDEEANQAHD (in Ref. 2; AAC72940).	retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane					0	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		GGTACATCCCGTTCACACATG	0.547												
ARHGEF16	27237	broad.mit.edu	37	1	3395142	3395142	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:3395142C>T	uc001akg.3	+	12	2028	c.1780C>T	c.(1780-1782)CGC>TGC	p.R594C	ARHGEF16_uc001aki.2_Missense_Mutation_p.R306C|ARHGEF16_uc001akj.2_Missense_Mutation_p.R306C|ARHGEF16_uc010nzh.1_Missense_Mutation_p.R298C	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	594	PH.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		CAGCGAGGGCCGCCAGGAGCA	0.677												
MEGF6	1953	broad.mit.edu	37	1	3431982	3431982	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:3431982G>A	uc001akl.2	-	6	941	c.714C>T	c.(712-714)GAC>GAT	p.D238D	MEGF6_uc001akk.2_Silent_p.D133D	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	238	EGF-like 4.|EGF-like 3.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		AATGCCTGCCGTCCTCCTGGA	0.677												
KIAA0562	9731	broad.mit.edu	37	1	3765295	3765295	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:3765295C>T	uc001aky.2	-	3	523	c.164G>A	c.(163-165)CGA>CAA	p.R55Q	KIAA0562_uc010nzm.1_RNA|KIAA0562_uc001akz.2_Missense_Mutation_p.R55Q	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	55						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		TTTCCTTATTCGACATCTCTC	0.358												
DFFB	1677	broad.mit.edu	37	1	3789133	3789133	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:3789133A>G	uc001alc.2	+	6	1102	c.779A>G	c.(778-780)CAC>CGC	p.H260R	DFFB_uc001ale.2_RNA|DFFB_uc009vlp.2_RNA|DFFB_uc001alb.2_RNA|DFFB_uc010nzn.1_Missense_Mutation_p.H284R|DFFB_uc009vlq.2_RNA|DFFB_uc009vlr.2_Missense_Mutation_p.H211R|DFFB_uc001ald.2_Missense_Mutation_p.H196R	NM_004402	NP_004393	O76075	DFFB_HUMAN	DNA fragmentation factor, 40 kD, beta	260					apoptotic chromosome condensation|DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction	cytosol|nucleoplasm	deoxyribonuclease activity|enzyme binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;2.05e-30)|all_epithelial(116;6.22e-21)|all_lung(118;2.65e-08)|Lung NSC(185;6.25e-06)|Breast(487;0.000659)|Renal(390;0.00121)|all_neural(13;0.0019)|Hepatocellular(190;0.00705)|Colorectal(325;0.0113)|all_hematologic(16;0.0194)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0548)|Medulloblastoma(700;0.211)		Epithelial(90;1.18e-39)|OV - Ovarian serous cystadenocarcinoma(86;7.28e-23)|GBM - Glioblastoma multiforme(42;2.95e-17)|Colorectal(212;1.23e-05)|COAD - Colon adenocarcinoma(227;5.94e-05)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00038)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		AACCTGGATCACATGTAAGCT	0.398												
CHD5	26038	broad.mit.edu	37	1	6169955	6169955	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:6169955G>A	uc001amb.1	-	38	5578	c.5478C>T	c.(5476-5478)AAC>AAT	p.N1826N	CHD5_uc001alz.1_Silent_p.N683N|CHD5_uc001ama.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1826					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCAGGCGGGCGTTGAGGGCCA	0.657												
SLC45A1	50651	broad.mit.edu	37	1	8384692	8384692	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:8384692C>T	uc001apb.2	+	1	303	c.303C>T	c.(301-303)TAC>TAT	p.Y101Y		NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	101	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AGTTCAGCTACGCCATGGAGA	0.632												
RERE	473	broad.mit.edu	37	1	8420774	8420774	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:8420774C>T	uc001ape.2	-	19	3603	c.2793G>A	c.(2791-2793)CCG>CCA	p.P931P	RERE_uc001apf.2_Silent_p.P931P|RERE_uc010nzx.1_Silent_p.P663P|RERE_uc001apd.2_Silent_p.P377P	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	931	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GAGTGGTAGGCGGGGGCTTGA	0.687												
CA6	765	broad.mit.edu	37	1	9017324	9017324	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:9017324G>A	uc001apm.2	+	3	412	c.388G>A	c.(388-390)GGG>AGG	p.G130R	CA6_uc009vmn.2_Missense_Mutation_p.G70R	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	130					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		CACCGTGGACGGGATCAGACA	0.483												
TMEM201	199953	broad.mit.edu	37	1	9656943	9656943	+	Silent	SNP	C	C	T	rs143914018		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:9656943C>T	uc001apz.2	+	3	273	c.261C>T	c.(259-261)CCC>CCT	p.P87P	TMEM201_uc001apy.2_Silent_p.P87P	NM_001130924	NP_001124396	Q5SNT2	TM201_HUMAN	transmembrane protein 201 isoform 1	87						integral to membrane|nuclear inner membrane					0	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		AGCCGATCCCCGCCCAGTACT	0.672												
NMNAT1	64802	broad.mit.edu	37	1	10042553	10042553	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:10042553G>A	uc001aqp.2	+	5	778	c.634G>A	c.(634-636)GTG>ATG	p.V212M		NM_022787	NP_073624	Q9HAN9	NMNA1_HUMAN	nicotinamide mononucleotide adenylyltransferase	212					water-soluble vitamin metabolic process	nucleoplasm	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|protein binding				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.31e-08)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(185;0.00028)|BRCA - Breast invasive adenocarcinoma(304;0.00032)|KIRC - Kidney renal clear cell carcinoma(229;0.00101)|STAD - Stomach adenocarcinoma(132;0.00908)|READ - Rectum adenocarcinoma(331;0.0419)		CAACATTCACGTGGTGAATGA	0.483												
CASZ1	54897	broad.mit.edu	37	1	10706296	10706296	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:10706296C>T	uc001aro.2	-	17	3905	c.3585G>A	c.(3583-3585)ACG>ACA	p.T1195T		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CCTTGCCAGACGTTTTGCAGA	0.537												
MTOR	2475	broad.mit.edu	37	1	11168277	11168277	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:11168277G>A	uc001asd.2	-	57	7716	c.7595C>T	c.(7594-7596)GCG>GTG	p.A2532V	MTOR_uc001asc.2_Missense_Mutation_p.A737V	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2532	FATC.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						ATGGGATGTCGCTTGTTTGAT	0.473												
KAZ	23254	broad.mit.edu	37	1	15428216	15428216	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:15428216G>T	uc001avm.3	+	11	2006	c.1725G>T	c.(1723-1725)CAG>CAT	p.Q575H	KAZ_uc001avs.3_Missense_Mutation_p.Q22H	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	575	SAM 2.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						AGTTCCACCAGGTCAGCATCC	0.597												
RSC1A1	6248	broad.mit.edu	37	1	15987413	15987413	+	Silent	SNP	G	G	A	rs142914242		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:15987413G>A	uc010obn.1	+	1	1050	c.1050G>A	c.(1048-1050)CCG>CCA	p.P350P		NM_006511	NP_006502	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1,	350					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			ovary(1)	1		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AATCTTGCCCGTCTATAACGG	0.408												
ARHGEF19	128272	broad.mit.edu	37	1	16525645	16525645	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:16525645C>T	uc001ayc.1	-	15	2388	c.2251G>A	c.(2251-2253)GGC>AGC	p.G751S	ARHGEF19_uc009voo.1_Missense_Mutation_p.G104S|ARHGEF19_uc001ayb.1_Missense_Mutation_p.G228S	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	751	SH3.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCCCTCACCGTCACTGGTC	0.557												
PADI2	11240	broad.mit.edu	37	1	17431556	17431556	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:17431556G>A	uc001baf.2	-	2	175	c.93C>T	c.(91-93)AGC>AGT	p.S31S	PADI2_uc010ocm.1_Silent_p.S31S|PADI2_uc001bag.1_Silent_p.S31S	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	31					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CTGGGGCCGCGCTGTGGGGAG	0.572												
PAX7	5081	broad.mit.edu	37	1	19062344	19062344	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:19062344C>T	uc001bay.2	+	8	1972	c.1374C>T	c.(1372-1374)GCC>GCT	p.A458A	PAX7_uc001baz.2_Silent_p.A456A|PAX7_uc010oct.1_Silent_p.A458A	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	458					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.A458A(1)	PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		ACCCCGTGGCCGGCTATCAGT	0.672			T	FOXO1A	alveolar rhabdomyosarcoma							
HSPG2	3339	broad.mit.edu	37	1	22181934	22181934	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:22181934C>T	uc001bfj.2	-	47	5900	c.5860G>A	c.(5860-5862)GGT>AGT	p.G1954S	HSPG2_uc009vqd.2_Missense_Mutation_p.G1955S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1954	Ig-like C2-type 4.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CTGGGCCCACCGCCCCCTGCA	0.687												
EPHB2	2048	broad.mit.edu	37	1	23208938	23208938	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:23208938G>A	uc009vqj.1	+	6	1535	c.1390G>A	c.(1390-1392)GGC>AGC	p.G464S	EPHB2_uc001bge.2_Missense_Mutation_p.G464S|EPHB2_uc001bgf.2_Missense_Mutation_p.G464S|EPHB2_uc010odu.1_Missense_Mutation_p.G464S	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	464	Fibronectin type-III 2.|Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CCAGCCCAATGGCGTGATCCT	0.612									Hereditary_Prostate_Cancer			
ASAP3	55616	broad.mit.edu	37	1	23760793	23760793	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:23760793G>T	uc001bha.2	-	19	2029	c.1905C>A	c.(1903-1905)CCC>CCA	p.P635P	ASAP3_uc001bgy.1_Silent_p.P139P|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Silent_p.P504P|ASAP3_uc010oea.1_Silent_p.P626P|ASAP3_uc001bhb.2_Silent_p.P158P	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	635	ANK 2.				regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						TGAGGCAGTCGGGCTGGTTGT	0.493												
EXTL1	2134	broad.mit.edu	37	1	26357744	26357744	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:26357744A>G	uc001blf.2	+	5	2090	c.1223A>G	c.(1222-1224)TAC>TGC	p.Y408C		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	408	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CCCTTCTACTACCTGCAACAG	0.612												
ARID1A	8289	broad.mit.edu	37	1	27106862	27106862	+	Missense_Mutation	SNP	G	G	A	rs142069738		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:27106862G>A	uc001bmv.1	+	20	6846	c.6473G>A	c.(6472-6474)CGA>CAA	p.R2158Q	ARID1A_uc001bmu.1_Missense_Mutation_p.R1941Q|ARID1A_uc001bmx.1_Missense_Mutation_p.R1004Q|ARID1A_uc009vsm.1_Missense_Mutation_p.R486Q|ARID1A_uc009vsn.1_Missense_Mutation_p.R400Q	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2158					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.R2158*(1)		ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTCAGTGACCGAAAGAACCCG	0.597			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC							
MATN1	4146	broad.mit.edu	37	1	31194535	31194535	+	Missense_Mutation	SNP	C	C	T	rs147880584		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:31194535C>T	uc001brz.2	-	2	192	c.158G>A	c.(157-159)CGG>CAG	p.R53Q	uc001bsb.1_RNA|MATN1_uc001bsa.1_5'Flank	NM_002379	NP_002370	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein precursor	53	VWFA 1.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)	1		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		TTCAACAGGCCGAACGCTGCG	0.607												
PUM1	9698	broad.mit.edu	37	1	31452917	31452917	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:31452917G>A	uc001bsi.1	-	9	1459	c.1346C>T	c.(1345-1347)GCG>GTG	p.A449V	PUM1_uc001bsf.1_Missense_Mutation_p.A115V|PUM1_uc001bsg.1_Missense_Mutation_p.A262V|PUM1_uc001bsh.1_Missense_Mutation_p.A449V|PUM1_uc001bsj.1_Missense_Mutation_p.A450V|PUM1_uc010oga.1_Missense_Mutation_p.A353V|PUM1_uc001bsk.1_Missense_Mutation_p.A485V|PUM1_uc010ogb.1_Missense_Mutation_p.A390V	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	449	Ala-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		ACCTAGTGTCGCTGCTGCAGC	0.493												
TMEM39B	55116	broad.mit.edu	37	1	32557419	32557419	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:32557419C>T	uc010ogv.1	+	6	880	c.734C>T	c.(733-735)ACG>ATG	p.T245M	TMEM39B_uc010ogt.1_RNA|TMEM39B_uc010ogu.1_Missense_Mutation_p.T118M|TMEM39B_uc001bue.3_Missense_Mutation_p.T246M|TMEM39B_uc001buf.3_Missense_Mutation_p.T46M|TMEM39B_uc010ogw.1_Missense_Mutation_p.T46M	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	245						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTGCGGGAGACGTGGAAGCAG	0.642												
IQCC	55721	broad.mit.edu	37	1	32672879	32672879	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:32672879G>A	uc001bum.2	+	5	644	c.597G>A	c.(595-597)GCG>GCA	p.A199A	IQCC_uc009vua.2_Silent_p.A279A|IQCC_uc010ogz.1_Silent_p.A99A|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	199										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CCCCAGAGGCGGGCCCGATCA	0.567												
GJA4	2701	broad.mit.edu	37	1	35260514	35260514	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:35260514C>T	uc001bya.2	+	2	788	c.700C>T	c.(700-702)CGC>TGC	p.R234C	GJA4_uc009vul.2_Missense_Mutation_p.R310C|GJA4_uc009vum.1_Missense_Mutation_p.R234C	NM_002060	NP_002051	P35212	CXA4_HUMAN	connexin 37	234	Cytoplasmic (Potential).				cell-cell junction assembly	integral to plasma membrane				central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				CCTGCTGTGTCGCTGCCTCAG	0.602												
NCDN	23154	broad.mit.edu	37	1	36026733	36026733	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:36026733G>A	uc001bza.2	+	4	1108	c.981G>A	c.(979-981)ACG>ACA	p.T327T	NCDN_uc001bzb.2_Silent_p.T327T|NCDN_uc001bzc.2_Silent_p.T310T	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1	327					neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGACGGGCACGGAGGTGAAAG	0.627												
THRAP3	9967	broad.mit.edu	37	1	36757051	36757051	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:36757051C>T	uc001cae.3	+	6	2046	c.1822C>T	c.(1822-1824)CGT>TGT	p.R608C	THRAP3_uc001caf.3_Missense_Mutation_p.R608C	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	608					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACAGGAGTTTCGTTCCATTTT	0.463			T	USP6	aneurysmal bone cysts							
MTF1	4520	broad.mit.edu	37	1	38288328	38288328	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:38288328G>A	uc001cce.1	-	9	1373	c.1232C>T	c.(1231-1233)ACA>ATA	p.T411I	MTF1_uc009vvj.1_Missense_Mutation_p.T102I	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	411						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TGAATTTCCTGTGGATGGCGG	0.473												
MTF1	4520	broad.mit.edu	37	1	38305655	38305655	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:38305655G>A	uc001cce.1	-	3	725	c.584C>T	c.(583-585)ACG>ATG	p.T195M	MTF1_uc009vvj.1_Translation_Start_Site	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	195						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CTTCTCCTTCGTGTGCACTCG	0.537												
NT5C1A	84618	broad.mit.edu	37	1	40131856	40131856	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:40131856C>T	uc001cdq.1	-	2	188	c.188G>A	c.(187-189)CGC>CAC	p.R63H		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	63					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CTCGTCCATGCGAAACAAGGC	0.597												
FOXJ3	22887	broad.mit.edu	37	1	42776750	42776750	+	Silent	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:42776750T>A	uc001che.2	-	4	327	c.15A>T	c.(13-15)GGA>GGT	p.G5G	FOXJ3_uc001chf.2_Silent_p.G5G|FOXJ3_uc001chg.2_Silent_p.G5G|FOXJ3_uc001chh.1_Silent_p.G5G	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	5					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GACAAGCCTGTCCATACAAAC	0.328												
PTPRF	5792	broad.mit.edu	37	1	44069662	44069662	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:44069662C>T	uc001cjr.2	+	16	3179	c.2839C>T	c.(2839-2841)CGC>TGC	p.R947C	PTPRF_uc001cjs.2_Missense_Mutation_p.R938C|PTPRF_uc001cju.2_Intron|PTPRF_uc009vwt.2_Missense_Mutation_p.R507C|PTPRF_uc001cjv.2_Missense_Mutation_p.R407C|PTPRF_uc001cjw.2_Missense_Mutation_p.R173C	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	947	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAGGAACGGGCGCATCATCAG	0.602												
TOE1	114034	broad.mit.edu	37	1	45809251	45809251	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:45809251T>C	uc009vxq.2	+	8	1993	c.1410T>C	c.(1408-1410)CCT>CCC	p.P470P	TOE1_uc001cnq.3_RNA|TOE1_uc010olm.1_Silent_p.P390P|TOE1_uc001cnr.3_RNA	NM_025077	NP_079353	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	470						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)					CCTGGCTCCCTGAATGCCACA	0.532												
TESK2	10420	broad.mit.edu	37	1	45813598	45813598	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:45813598G>A	uc001cns.1	-	6	1018	c.615C>T	c.(613-615)CCC>CCT	p.P205P	TESK2_uc009vxr.1_Silent_p.P205P|TESK2_uc010olo.1_Silent_p.P122P|TESK2_uc009vxs.1_5'UTR	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	205	Protein kinase.				actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					ACCTGACATCGGGGATCTTCT	0.542												
CCDC17	149483	broad.mit.edu	37	1	46088681	46088681	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:46088681C>T	uc010olt.1	-	4	750	c.602G>A	c.(601-603)CGG>CAG	p.R201Q	CCDC17_uc009vxy.2_Missense_Mutation_p.R169Q|CCDC17_uc010ols.1_Missense_Mutation_p.R192Q|CCDC17_uc001com.3_Missense_Mutation_p.R22Q|CCDC17_uc001con.3_RNA|CCDC17_uc009vxz.2_Intron	NM_001114938	NP_001108410	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	201	Potential.									ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TAGAGCTCCCCGCGTCCTCCC	0.672												
GLIS1	148979	broad.mit.edu	37	1	54059810	54059810	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:54059810G>A	uc001cvr.1	-	3	1333	c.766C>T	c.(766-768)CAC>TAC	p.H256Y		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	256	C2H2-type 2; atypical.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCGCCCGAGTGCACTCGCATG	0.662												
INADL	10207	broad.mit.edu	37	1	62503676	62503676	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:62503676C>T	uc001dab.2	+	30	4101	c.3987C>T	c.(3985-3987)GCC>GCT	p.A1329A	INADL_uc009waf.1_Silent_p.A1329A|INADL_uc001daa.2_Silent_p.A1329A|INADL_uc001dad.3_Silent_p.A1026A|INADL_uc001dac.2_RNA|INADL_uc010oot.1_Silent_p.A113A|INADL_uc009wag.2_Silent_p.A113A|INADL_uc010oou.1_Silent_p.A2A	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1329					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						ATCAGATGGCCGTTACTCCCT	0.378												
MIER1	57708	broad.mit.edu	37	1	67450349	67450349	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:67450349A>C	uc001dde.2	+	14	1598	c.1464A>C	c.(1462-1464)AAA>AAC	p.K488N	MIER1_uc010opf.1_Intron|MIER1_uc009way.2_Intron|MIER1_uc001ddc.2_Intron|MIER1_uc001ddh.2_Intron|MIER1_uc001ddf.2_Missense_Mutation_p.K452N|MIER1_uc001ddg.2_Missense_Mutation_p.K408N|MIER1_uc010opg.1_Missense_Mutation_p.K452N|MIER1_uc001ddj.1_Missense_Mutation_p.K435N|MIER1_uc001ddi.2_Intron	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b	459					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1						GAAATAAGAAACCACTTCATG	0.363												
SERBP1	26135	broad.mit.edu	37	1	67880887	67880887	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:67880887G>A	uc001ddv.2	-	7	1272	c.1132C>T	c.(1132-1134)CGT>TGT	p.R378C	SERBP1_uc001ddx.2_Missense_Mutation_p.R372C|SERBP1_uc001ddy.2_Missense_Mutation_p.R357C|SERBP1_uc001ddw.2_Missense_Mutation_p.R363C	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	378					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						CGCCCACCACGCCCACGTCCA	0.532												
TNNI3K	51086	broad.mit.edu	37	1	74957869	74957869	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:74957869G>A	uc001dgf.1	+	23	2321	c.2270G>A	c.(2269-2271)CGG>CAG	p.R757Q	TNNI3K_uc001dge.1_Missense_Mutation_p.R858Q	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	757						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						GGACCTGGCCGGAGTCATGTG	0.488												
C1orf173	127254	broad.mit.edu	37	1	75037295	75037295	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:75037295C>T	uc001dgg.2	-	14	4318	c.4099G>A	c.(4099-4101)GAG>AAG	p.E1367K		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1367	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTTTTCTCCTCGGCTGTCTCC	0.517												
FUBP1	8880	broad.mit.edu	37	1	78422353	78422353	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:78422353A>G	uc001dii.2	-	17	1698	c.1609T>C	c.(1609-1611)TGG>CGG	p.W537R	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.W558R	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	537	Pro-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						TAAGCAGCCCAAGCTGCTGAA	0.453												
PKN2	5586	broad.mit.edu	37	1	89206691	89206691	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:89206691G>A	uc001dmn.2	+	2	411	c.69G>A	c.(67-69)CCG>CCA	p.P23P	PKN2_uc001dmm.1_Silent_p.P23P|PKN2_uc010osp.1_Silent_p.P23P|PKN2_uc010osq.1_Intron|PKN2_uc009wcv.2_Silent_p.P23P	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	23					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GAAGTCTTCCGTTTTCTGAGA	0.378												
HFM1	164045	broad.mit.edu	37	1	91844741	91844741	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:91844741C>T	uc001doa.3	-	9	1137	c.1037G>A	c.(1036-1038)CGT>CAT	p.R346H	HFM1_uc010osu.1_Missense_Mutation_p.R25H|HFM1_uc010osv.1_Missense_Mutation_p.R30H|HFM1_uc001doc.1_Missense_Mutation_p.R346H	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	346	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GTCATCAAAACGCTGACTGCA	0.323												
EVI5	7813	broad.mit.edu	37	1	93029202	93029202	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:93029202A>G	uc001dox.2	-	17	2125	c.2115T>C	c.(2113-2115)CAT>CAC	p.H705H	EVI5_uc010otf.1_Silent_p.H716H|EVI5_uc001doy.1_RNA	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	705	Targeting to the centrosomes.|Potential.|Interaction with AURKB and INCENP.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		CACTTACCTCATGATTCAGCT	0.358												
KCNA2	3737	broad.mit.edu	37	1	111146149	111146149	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:111146149C>T	uc001dzu.2	-	2	1752	c.1256G>A	c.(1255-1257)CGG>CAG	p.R419Q	KCNA2_uc009wfv.1_Intron|KCNA2_uc009wfw.2_Missense_Mutation_p.R419Q	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	419						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CTCTGTCTCCCGGTGGTAGAA	0.498												
WNT2B	7482	broad.mit.edu	37	1	113033683	113033683	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:113033683G>A	uc001eca.2	+	2	225	c.105G>A	c.(103-105)GCG>GCA	p.A35A	WNT2B_uc009wgg.2_Intron	NM_004185	NP_004176	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family,	Error:Variant_position_missing_in_Q93097_after_alignment					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		cacagtcagcgttcaacaagt	0.07												
SLC22A15	55356	broad.mit.edu	37	1	116609275	116609275	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:116609275G>A	uc001egb.3	+	11	1630	c.1500G>A	c.(1498-1500)TCG>TCA	p.S500S		NM_018420	NP_060890	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	500					ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		AGGTGTATTCGTATCGCAGGC	0.488												
IGSF3	3321	broad.mit.edu	37	1	117146451	117146451	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:117146451C>T	uc001egr.1	-	6	2124	c.1419G>A	c.(1417-1419)TCG>TCA	p.S473S	IGSF3_uc001egq.1_Silent_p.S493S|IGSF3_uc001egs.1_Silent_p.S146S	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	473	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CCCAGTAGGACGAGCCTGGCT	0.622												
TRIM45	80263	broad.mit.edu	37	1	117661189	117661189	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:117661189A>G	uc001egz.2	-	2	1277	c.689T>C	c.(688-690)GTC>GCC	p.V230A	TRIM45_uc009whe.2_Missense_Mutation_p.V230A|TRIM45_uc001eha.2_Missense_Mutation_p.V126A	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	230						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		CTTGTGGATGACATTGCTGGT	0.577												
SPAG17	200162	broad.mit.edu	37	1	118634309	118634309	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:118634309T>C	uc001ehk.2	-	10	1347	c.1279A>G	c.(1279-1281)AGA>GGA	p.R427G		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	427						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTGTAATATCTCATGTCTACT	0.373												
SPAG17	200162	broad.mit.edu	37	1	118642346	118642346	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:118642346C>T	uc001ehk.2	-	6	780	c.712G>A	c.(712-714)GCT>ACT	p.A238T		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	238						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCAAGCTCAGCCATAATTGCT	0.418												
ADAM30	11085	broad.mit.edu	37	1	120437609	120437609	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:120437609G>A	uc001eij.2	-	1	1505	c.1351C>T	c.(1351-1353)CGT>TGT	p.R451C		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	451	Disintegrin.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CCAGATGGACGAAACCGACAA	0.463												
POLR3C	10623	broad.mit.edu	37	1	145608566	145608566	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:145608566G>A	uc001eoh.2	-	3	402	c.241C>T	c.(241-243)CGG>TGG	p.R81W	NBPF10_uc001emp.3_Intron|RNF115_uc001eoj.2_5'Flank|RNF115_uc001eok.2_5'Flank|RNF115_uc009wiy.2_5'Flank|POLR3C_uc001eog.2_Missense_Mutation_p.R94W|POLR3C_uc001eoi.2_Intron|POLR3C_uc009wix.2_Missense_Mutation_p.R81W	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	81					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			CGCAATACCCGGCTGCACTGG	0.483												
PLEKHO1	51177	broad.mit.edu	37	1	150123100	150123100	+	Splice_Site	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:150123100A>G	uc001ett.2	+	2	309	c.31_splice	c.e2-2	p.G11_splice	PLEKHO1_uc001etr.2_Splice_Site|PLEKHO1_uc001ets.2_Splice_Site	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O							cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCCTGGGGCAGGGACCTCAG	0.617												
VPS72	6944	broad.mit.edu	37	1	151149142	151149142	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:151149142C>T	uc001exe.1	-	6	1116	c.1073G>A	c.(1072-1074)CGC>CAC	p.R358H	TMOD4_uc001exd.2_5'Flank|TMOD4_uc001exc.3_5'Flank|TMOD4_uc010pct.1_5'Flank	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	358					chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			AATTTTCTGGCGCAAGGCTCG	0.582												
ZNF687	57592	broad.mit.edu	37	1	151261166	151261166	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:151261166C>T	uc001exq.2	+	3	2376	c.2278C>T	c.(2278-2280)CGC>TGC	p.R760C	ZNF687_uc009wmo.2_Missense_Mutation_p.R760C|ZNF687_uc009wmp.2_Missense_Mutation_p.R760C	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	760					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCACGTCTCTCGCCGTGTAGG	0.562												
FLG	2312	broad.mit.edu	37	1	152275642	152275642	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:152275642C>T	uc001ezu.1	-	3	11756	c.11720G>A	c.(11719-11721)CGC>CAC	p.R3907H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3907	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCTGTATCGCGGTGAGAGGA	0.502									Ichthyosis			
FLG	2312	broad.mit.edu	37	1	152283084	152283084	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:152283084G>A	uc001ezu.1	-	3	4314	c.4278C>T	c.(4276-4278)TCC>TCT	p.S1426S	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1426	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCACGTGCGGACTCTTTGT	0.557									Ichthyosis			
FLG	2312	broad.mit.edu	37	1	152284397	152284397	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:152284397G>A	uc001ezu.1	-	3	3001	c.2965C>T	c.(2965-2967)CAC>TAC	p.H989Y	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	989	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCTTCGTGATGGGACCTG	0.572									Ichthyosis			
FLG	2312	broad.mit.edu	37	1	152284999	152284999	+	Missense_Mutation	SNP	C	C	T	rs142483068	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:152284999C>T	uc001ezu.1	-	3	2399	c.2363G>A	c.(2362-2364)CGA>CAA	p.R788Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	788	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTGAACGTCGAGACCTTTC	0.567									Ichthyosis			
LCE2C	353140	broad.mit.edu	37	1	152648744	152648744	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:152648744C>T	uc001fah.2	+	2	308	c.253C>T	c.(253-255)CGG>TGG	p.R85W		NM_178429	NP_848516	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	85	Cys-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACCGGCGCCGGCACCAGAG	0.682												
UBAP2L	9898	broad.mit.edu	37	1	154229634	154229634	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:154229634T>A	uc001fep.3	+	19	2420	c.2253T>A	c.(2251-2253)AGT>AGA	p.S751R	UBAP2L_uc009wot.2_Missense_Mutation_p.S751R|UBAP2L_uc010pek.1_Missense_Mutation_p.S743R|UBAP2L_uc010pel.1_Missense_Mutation_p.S761R|UBAP2L_uc010pen.1_Missense_Mutation_p.S665R|UBAP2L_uc001feq.2_5'UTR|UBAP2L_uc001fer.2_5'UTR	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	751					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAGTGGTCAGTGTCTCCTCCA	0.552												
ADAR	103	broad.mit.edu	37	1	154557387	154557387	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:154557387G>A	uc001ffh.2	-	15	3776	c.3576C>T	c.(3574-3576)TAC>TAT	p.Y1192Y	ADAR_uc001ffj.2_Silent_p.Y1147Y|ADAR_uc001ffi.2_Silent_p.Y1166Y|ADAR_uc001ffk.2_Silent_p.Y897Y	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	1192	A to I editase.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TGGCCGTCTCGTAGTCACGGG	0.473												
HCN3	57657	broad.mit.edu	37	1	155252423	155252423	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:155252423G>A	uc001fjz.1	+	2	508	c.500G>A	c.(499-501)CGC>CAC	p.R167H	RAG1AP1_uc010pey.1_Intron|HCN3_uc010pfz.1_5'UTR	NM_020897	NP_065948	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic	167	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)|breast(1)	2	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ATCCGCACGCGCTACCTGCGC	0.587												
LMNA	4000	broad.mit.edu	37	1	156108451	156108451	+	Missense_Mutation	SNP	G	G	A	rs13768		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:156108451G>A	uc001fni.2	+	11	2120	c.1871G>A	c.(1870-1872)CGC>CAC	p.R624H	LMNA_uc001fnf.1_3'UTR|LMNA_uc001fnh.2_Missense_Mutation_p.R594H|LMNA_uc009wro.1_Intron|LMNA_uc001fnj.2_3'UTR|LMNA_uc001fnk.2_Missense_Mutation_p.R525H|LMNA_uc010pha.1_3'UTR|LMNA_uc010phb.1_RNA	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	624	Tail.		R -> H (in EDMD2).		cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					ACGGTCACTCGCAGCTACCGC	0.677									Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome			
CCT3	7203	broad.mit.edu	37	1	156303398	156303398	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:156303398C>T	uc001fol.1	-	5	464	c.244G>A	c.(244-246)GAA>AAA	p.E82K	CCT3_uc001fom.1_Missense_Mutation_p.E82K|CCT3_uc001fon.1_Missense_Mutation_p.E44K|CCT3_uc010phj.1_Missense_Mutation_p.E36K|CCT3_uc010phk.1_Missense_Mutation_p.E36K|CCT3_uc010phl.1_Missense_Mutation_p.E36K	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	82					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CGGCTAATTTCGATCATGGAC	0.423												
PEAR1	375033	broad.mit.edu	37	1	156883740	156883740	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:156883740G>C	uc001fqj.1	+	22	2926	c.2810G>C	c.(2809-2811)GGC>GCC	p.G937A	PEAR1_uc001fqk.1_Missense_Mutation_p.G562A	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	937	Pro-rich.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTGCCAGGGGGCCCCCGGGAG	0.647												
OR10T2	128360	broad.mit.edu	37	1	158368816	158368816	+	Silent	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:158368816A>C	uc010pih.1	-	1	441	c.441T>G	c.(439-441)TCT>TCG	p.S147S		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CTCCTGAGAGAGAAATCAACT	0.458												
SPTA1	6708	broad.mit.edu	37	1	158621239	158621239	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:158621239G>T	uc001fst.1	-	24	3594	c.3395C>A	c.(3394-3396)CCT>CAT	p.P1132H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1132	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCTTAGCCGAGGCTCATTGGT	0.423												
SLAMF8	56833	broad.mit.edu	37	1	159799702	159799702	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:159799702C>T	uc001fue.3	+	2	297	c.87C>T	c.(85-87)GTC>GTT	p.V29V		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	29	Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					TGAGCAAAGTCGGGGGCTCGG	0.602												
HSD17B7	51478	broad.mit.edu	37	1	162762614	162762614	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:162762614G>A	uc001gci.2	+	2	296	c.201G>A	c.(199-201)CTG>CTA	p.L67L	HSD17B7_uc009wuv.2_RNA	NM_016371	NP_057455	P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	67	Extracellular (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			ovary(1)	1	all_hematologic(112;0.115)				NADH(DB00157)	TCAGCAACCTGCAGTCGGTCT	0.493												
ATP1B1	481	broad.mit.edu	37	1	169100579	169100579	+	RNA	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:169100579G>A	uc001gfs.1	+	6		c.823G>A						P05026	AT1B1_HUMAN	Synthetic construct DNA, clone: pF1KB8186, Homo sapiens ATP1B1 gene for ATPase, Na+/K+ transporting, beta 1 polypeptide, without stop codon, in Flexi system.						ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	all_hematologic(923;0.208)					TTTGGACTGGGCAACTCCCCT	0.443												
RC3H1	149041	broad.mit.edu	37	1	173912741	173912741	+	Silent	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:173912741T>G	uc001gju.3	-	17	3061	c.2974A>C	c.(2974-2976)AGG>CGG	p.R992R	RC3H1_uc010pms.1_Intron|RC3H1_uc001gjv.2_Intron|RC3H1_uc010pmt.1_Silent_p.R992R	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	992					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						AACACCAGCCTGTTACTAACA	0.532												
RC3H1	149041	broad.mit.edu	37	1	173953746	173953746	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:173953746C>T	uc001gju.3	-	2	330	c.243G>A	c.(241-243)CAG>CAA	p.Q81Q	RC3H1_uc010pms.1_Silent_p.Q81Q|RC3H1_uc001gjv.2_Silent_p.Q81Q|RC3H1_uc010pmt.1_Silent_p.Q81Q	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	81					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TAATAGGCTGCTGCTCAGGGA	0.388												
XPR1	9213	broad.mit.edu	37	1	180775653	180775653	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:180775653C>A	uc001goi.2	+	6	833	c.641C>A	c.(640-642)GCT>GAT	p.A214D	XPR1_uc009wxm.2_Missense_Mutation_p.A214D|XPR1_uc009wxn.2_Missense_Mutation_p.A214D	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	214	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						AGACAAAAGGCTATGAAGCGT	0.383												
ZNF648	127665	broad.mit.edu	37	1	182026636	182026636	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:182026636A>G	uc001goz.2	-	2	718	c.510T>C	c.(508-510)AAT>AAC	p.N170N		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GATACTTTCCATTGCTGGGGA	0.577												
C1orf21	81563	broad.mit.edu	37	1	184446659	184446659	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:184446659G>A	uc001gqv.1	+	2	493	c.16G>A	c.(16-18)GCC>ACC	p.A6T		NM_030806	NP_110433	Q9H246	CA021_HUMAN	chromosome 1 open reading frame 21	6											0		Breast(1374;0.00262)		Colorectal(1306;4.8e-08)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)		CTGTGCCTCCGCCAAGCATGT	0.463												
TPR	7175	broad.mit.edu	37	1	186313658	186313658	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:186313658T>C	uc001grv.2	-	25	3563	c.3266A>G	c.(3265-3267)CAT>CGT	p.H1089R		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1089	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ATCAGCAGCATGCAGCATCAA	0.383			T	NTRK1	papillary thyroid							
PTGS2	5743	broad.mit.edu	37	1	186645044	186645044	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:186645044G>A	uc001gsb.2	-	8	1380	c.1243C>T	c.(1243-1245)CAA>TAA	p.Q415*	PTGS2_uc009wyo.2_Nonsense_Mutation_p.Q262*	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	415					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	CCAGCAATTTGCCTGGTGAAT	0.333												
RGS2	5997	broad.mit.edu	37	1	192780201	192780201	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:192780201C>A	uc001gsl.2	+	4	398	c.365C>A	c.(364-366)ACC>AAC	p.T122N		NM_002923	NP_002914	P41220	RGS2_HUMAN	regulator of G-protein signaling 2	122	RGS.				cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity				0						TTCAAAAAAACCAAATCACCC	0.393												
B3GALT2	8707	broad.mit.edu	37	1	193149443	193149443	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:193149443C>T	uc001gtc.3	-	2	1965	c.1250G>A	c.(1249-1251)CGC>CAC	p.R417H	CDC73_uc001gtb.2_Intron	NM_003783	NP_003774	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta	417	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1						TTTACGGTGGCGATACCTGCC	0.368												
F13B	2165	broad.mit.edu	37	1	197031010	197031010	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:197031010C>T	uc001gtt.1	-	3	399	c.355G>A	c.(355-357)GCT>ACT	p.A119T		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	119	Sushi 2.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TACCCTGAAGCGCAACCATAA	0.403												
DENND1B	163486	broad.mit.edu	37	1	197480898	197480898	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:197480898T>A	uc010ppe.1	-	21	2053	c.1715A>T	c.(1714-1716)GAT>GTT	p.D572V	DENND1B_uc010ppf.1_RNA	NM_001142795	NP_001136267	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 1	Error:Variant_position_missing_in_Q6P3S1_after_alignment						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						TCTAAAGAAATCCAAGCTCTT	0.378												
KIF21B	23046	broad.mit.edu	37	1	200974489	200974489	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:200974489C>T	uc001gvs.1	-	5	996	c.679G>A	c.(679-681)GCC>ACC	p.A227T	KIF21B_uc001gvr.1_Missense_Mutation_p.A227T|KIF21B_uc009wzl.1_Missense_Mutation_p.A227T|KIF21B_uc010ppn.1_Missense_Mutation_p.A227T|KIF21B_uc001gvt.1_Missense_Mutation_p.A10T	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	227	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GTGAAGATGGCGTGGGAGCGT	0.637												
PKP1	5317	broad.mit.edu	37	1	201289420	201289420	+	Missense_Mutation	SNP	C	C	T	rs146785756		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:201289420C>T	uc001gwd.2	+	8	1572	c.1321C>T	c.(1321-1323)CGC>TGC	p.R441C	PKP1_uc001gwe.2_Missense_Mutation_p.R420C|PKP1_uc009wzm.2_Missense_Mutation_p.R28C	NM_000299	NP_000290	Q13835	PKP1_HUMAN	plakophilin 1 isoform 1b	441	ARM 5.				cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			ovary(2)	2						CGATGCAGGCCGCCAGACCAT	0.373												
PPFIA4	8497	broad.mit.edu	37	1	203040880	203040880	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:203040880C>T	uc001gyz.2	+	15	2460	c.1867C>T	c.(1867-1869)CTG>TTG	p.L623L	PPFIA4_uc009xaj.2_Silent_p.L1254L|PPFIA4_uc010pqf.1_Silent_p.L836L|PPFIA4_uc001gza.2_Silent_p.L614L|PPFIA4_uc001gzb.1_Silent_p.L309L|PPFIA4_uc001gzc.1_Silent_p.L165L	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	623					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						AGACCGGAAGCTGGATGACGT	0.527												
ADORA1	134	broad.mit.edu	37	1	203098074	203098074	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:203098074G>T	uc001gze.1	+	3	538	c.105G>T	c.(103-105)AAG>AAT	p.K35N	ADORA1_uc001gzf.1_Missense_Mutation_p.K35N|ADORA1_uc010pqg.1_Translation_Start_Site|ADORA1_uc009xak.1_Translation_Start_Site|ADORA1_uc010pqh.1_Missense_Mutation_p.K68N	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	35	Cytoplasmic (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GGGCGGTGAAGGTGAACCAGG	0.652												
LAMB3	3914	broad.mit.edu	37	1	209811925	209811925	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:209811925A>G	uc001hhg.2	-	3	642	c.252T>C	c.(250-252)AAT>AAC	p.N84N	LAMB3_uc009xco.2_Silent_p.N84N|LAMB3_uc001hhh.2_Silent_p.N84N|LAMB3_uc010psl.1_RNA|LAMB3_uc009xcp.1_Silent_p.N84N	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	84	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		ATGAAGCCACATTCTCTACTC	0.532												
SERTAD4	56256	broad.mit.edu	37	1	210415509	210415509	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:210415509G>A	uc001hhy.2	+	4	1077	c.898G>A	c.(898-900)GAA>AAA	p.E300K	SERTAD4_uc009xcw.2_Missense_Mutation_p.E300K	NM_019605	NP_062551	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	300							protein binding			ovary(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		CCTCAGCCACGAACCTGTGGG	0.398												
GPATCH2	55105	broad.mit.edu	37	1	217793680	217793680	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:217793680C>T	uc001hlf.1	-	2	314	c.218G>A	c.(217-219)CGG>CAG	p.R73Q	GPATCH2_uc001hlg.3_Missense_Mutation_p.R73Q	NM_018040	NP_060510	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	73						intracellular	nucleic acid binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		ATACGACCTCCGTTTTCTCCC	0.473												
RAB3GAP2	25782	broad.mit.edu	37	1	220369638	220369638	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:220369638A>G	uc010puk.1	-	10	1078	c.914T>C	c.(913-915)ATC>ACC	p.I305T	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_5'UTR	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	305					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		CCCTACAGTGATATACTGAGA	0.378												
LBR	3930	broad.mit.edu	37	1	225594521	225594521	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:225594521G>A	uc001hoy.2	-	11	1471	c.1328C>T	c.(1327-1329)ACG>ATG	p.T443M	LBR_uc001hoz.2_Missense_Mutation_p.T443M|LBR_uc001hpa.1_Missense_Mutation_p.T443M	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	443					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		GTCCATGGTCGTCAACAACGC	0.408												
RAB4A	5867	broad.mit.edu	37	1	229422273	229422273	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:229422273T>C	uc001hth.2	+	2	280	c.72T>C	c.(70-72)ACT>ACC	p.T24T	RAB4A_uc001hti.2_RNA|RAB4A_uc001htj.2_Intron	NM_004578	NP_004569	P20338	RAB4A_HUMAN	RAB4A, member RAS oncogene family	19	GTP.						GDP binding|GTP binding|GTPase activity			ovary(1)	1	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.178)				ATGCAGGAACTGGCAAATCTT	0.333												
ABCB10	23456	broad.mit.edu	37	1	229667403	229667403	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:229667403T>G	uc001htp.3	-	7	1458	c.1415A>C	c.(1414-1416)GAG>GCG	p.E472A		NM_012089	NP_036221	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B, member 10	472	Mitochondrial intermembrane (Potential).|Mitochondrial matrix (Potential).					integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity			breast(2)	2	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)				CAGCTTGGGCTCTCTCTCCAG	0.512												
URB2	9816	broad.mit.edu	37	1	229772399	229772399	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:229772399A>C	uc001hts.1	+	4	2175	c.2039A>C	c.(2038-2040)CAG>CCG	p.Q680P	URB2_uc009xfd.1_Missense_Mutation_p.Q680P	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	680						nucleolus				central_nervous_system(2)|ovary(1)	3						CTGTACCTGCAGAAAATGAAA	0.423												
NID1	4811	broad.mit.edu	37	1	236142400	236142400	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:236142400C>T	uc001hxo.2	-	19	3619	c.3517G>A	c.(3517-3519)GTG>ATG	p.V1173M	NID1_uc009xgd.2_Missense_Mutation_p.V1040M|NID1_uc009xgc.2_Missense_Mutation_p.V254M	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	1173					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	AGAGCAACCACGGAATTCCTA	0.488												
NID1	4811	broad.mit.edu	37	1	236154336	236154336	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:236154336C>T	uc001hxo.2	-	14	2880	c.2778G>A	c.(2776-2778)CCG>CCA	p.P926P	NID1_uc009xgd.2_Silent_p.P793P|NID1_uc009xgc.2_Silent_p.P12P	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	926					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CTTGGTGAATCGGGGGAGCCA	0.532												
ZP4	57829	broad.mit.edu	37	1	238048857	238048857	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:238048857C>T	uc001hym.2	-	8	994	c.994G>A	c.(994-996)GGT>AGT	p.G332S	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	332	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCACCAACACCGTAGTAAGAG	0.483												
KIF26B	55083	broad.mit.edu	37	1	245849621	245849621	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:245849621C>T	uc001ibf.1	+	12	3776	c.3336C>T	c.(3334-3336)GGC>GGT	p.G1112G	KIF26B_uc001ibg.1_Silent_p.G730G|KIF26B_uc001ibh.1_Silent_p.G354G	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1112					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGGATTCCGGCGTGGCGTCTA	0.617												
OR13G1	441933	broad.mit.edu	37	1	247836183	247836183	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:247836183G>A	uc001idi.1	-	1	161	c.161C>T	c.(160-162)ACG>ATG	p.T54M		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATACATGGGCGTATGCAAGGT	0.423												
OR2T8	343172	broad.mit.edu	37	1	248084867	248084867	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:248084867T>C	uc010pzc.1	+	1	548	c.548T>C	c.(547-549)GTG>GCG	p.V183A		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCCGTGCTGGTGCGTTTGGCT	0.552												
OR14I1	401994	broad.mit.edu	37	1	248845531	248845531	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:248845531G>A	uc001ieu.1	-	1	75	c.75C>T	c.(73-75)CAC>CAT	p.H25H		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	25	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACAGCCCGGCGTGCAGCACCT	0.493												
ZNF692	55657	broad.mit.edu	37	1	249149812	249149812	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:249149812C>T	uc001ifc.1	-	8	1071	c.904G>A	c.(904-906)GCT>ACT	p.A302T	ZNF692_uc001iez.1_Missense_Mutation_p.A24T|ZNF692_uc001ifa.1_Missense_Mutation_p.A24T|ZNF692_uc001ifb.1_Missense_Mutation_p.A98T|ZNF692_uc001ifd.1_Missense_Mutation_p.A301T|ZNF692_uc001ife.1_RNA|ZNF692_uc001iff.1_Missense_Mutation_p.A257T|ZNF692_uc010pzr.1_Missense_Mutation_p.A307T	NM_017865	NP_060335	Q9BU19	ZN692_HUMAN	zinc finger protein 692 isoform 2	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGGGTTGGAGCAGACTGGGCC	0.632												
PFKP	5214	broad.mit.edu	37	10	3155672	3155672	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:3155672G>A	uc001igp.2	+	13	1369	c.1333G>A	c.(1333-1335)GCC>ACC	p.A445T	PFKP_uc001igq.2_Missense_Mutation_p.A437T|PFKP_uc009xhr.2_Missense_Mutation_p.A407T|PFKP_uc009xhs.1_Missense_Mutation_p.A229T|PFKP_uc009xht.2_Missense_Mutation_p.A183T|PFKP_uc009xhu.2_5'UTR	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	445					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CAGGATGCTCGCCATCTATGA	0.642												
ITIH5	80760	broad.mit.edu	37	10	7608295	7608295	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:7608295C>T	uc001ijq.2	-	13	2304	c.2225G>A	c.(2224-2226)CGC>CAC	p.R742H	ITIH5_uc001ijp.2_Missense_Mutation_p.R528H	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	742					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GGTGATAGTGCGCAAGTAAGT	0.532												
ITIH5	80760	broad.mit.edu	37	10	7627891	7627891	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:7627891A>T	uc001ijq.2	-	8	1160	c.1081T>A	c.(1081-1083)TAC>AAC	p.Y361N	ITIH5_uc001ijp.2_Missense_Mutation_p.Y147N|ITIH5_uc001ijr.1_Missense_Mutation_p.Y361N	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	361	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TGGTGAATGTACACTTTCCCA	0.383												
UPF2	26019	broad.mit.edu	37	10	11990443	11990443	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:11990443T>A	uc001ila.2	-	15	3573	c.3099A>T	c.(3097-3099)GAA>GAT	p.E1033D	UPF2_uc001ilb.2_Missense_Mutation_p.E1033D|UPF2_uc001ilc.2_Missense_Mutation_p.E1033D	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	1033	Glu-rich.|Sufficient for interaction with EIF4A1 and EIF1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				cttcttcttcttcatcctctt	0.154												
UPF2	26019	broad.mit.edu	37	10	12070898	12070898	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:12070898C>T	uc001ila.2	-	2	1465	c.991G>A	c.(991-993)GCA>ACA	p.A331T	UPF2_uc001ilb.2_Missense_Mutation_p.A331T|UPF2_uc001ilc.2_Missense_Mutation_p.A331T|UPF2_uc009xiz.1_Missense_Mutation_p.A331T	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	331	MIF4G 1.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				AACTTCTCTGCAGCACTCTTT	0.403												
CUBN	8029	broad.mit.edu	37	10	16893340	16893340	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:16893340A>G	uc001ioo.2	-	60	9609	c.9557T>C	c.(9556-9558)GTA>GCA	p.V3186A	CUBN_uc009xjq.1_RNA	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3186	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TATGATCCATACACAGTTTAA	0.398												
CUBN	8029	broad.mit.edu	37	10	17147455	17147455	+	Splice_Site	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:17147455C>T	uc001ioo.2	-	11	1282	c.1230_splice	c.e11+1	p.I410_splice		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAAGGACTCACGATGCATTGT	0.418												
VIM	7431	broad.mit.edu	37	10	17278320	17278320	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:17278320T>C	uc001iou.2	+	9	1714	c.1301T>C	c.(1300-1302)GTT>GCT	p.V434A	VIM_uc001iov.1_Intron|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.V434A|VIM_uc001ioy.1_Missense_Mutation_p.V347A|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Missense_Mutation_p.V392A|VIM_uc001ipc.1_Intron	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	434	Tail.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						CTCCCTCTGGTTGATACCCAC	0.363												
GPR158	57512	broad.mit.edu	37	10	25887748	25887748	+	Missense_Mutation	SNP	C	C	T	rs146528842		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:25887748C>T	uc001isj.2	+	11	3253	c.3193C>T	c.(3193-3195)CGC>TGC	p.R1065C	GPR158_uc001isk.2_Missense_Mutation_p.R440C	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1065	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CAATCAGAAGCGCATAGATAA	0.458												
SVIL	6840	broad.mit.edu	37	10	29839766	29839766	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:29839766G>A	uc001iut.1	-	6	1340	c.587C>T	c.(586-588)CCG>CTG	p.P196L	SVIL_uc001iuu.1_Missense_Mutation_p.P196L|SVIL_uc009xld.1_Missense_Mutation_p.P196L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	196					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CAGCACCTCCGGGTCGGAAGA	0.612												
ZNF33A	7581	broad.mit.edu	37	10	38344404	38344404	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:38344404G>A	uc001izh.2	+	5	1527	c.1349G>A	c.(1348-1350)CGT>CAT	p.R450H	ZNF33A_uc001izg.2_Missense_Mutation_p.R451H|ZNF33A_uc010qev.1_Missense_Mutation_p.R457H|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	450	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						AAATCCTTCCGTGTGACTTCG	0.408												
SLC18A3	6572	broad.mit.edu	37	10	50819067	50819067	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:50819067C>T	uc001jhw.2	+	1	721	c.281C>T	c.(280-282)ACG>ATG	p.T94M	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	94	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						AGCGCCTACACGGCCAACACC	0.726												
PCDH15	65217	broad.mit.edu	37	10	55782869	55782869	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:55782869C>T	uc001jju.1	-	19	2704	c.2309G>A	c.(2308-2310)AGC>AAC	p.S770N	PCDH15_uc010qhq.1_Missense_Mutation_p.S775N|PCDH15_uc010qhr.1_Missense_Mutation_p.S770N|PCDH15_uc010qhs.1_Missense_Mutation_p.S782N|PCDH15_uc010qht.1_Missense_Mutation_p.S777N|PCDH15_uc010qhu.1_Missense_Mutation_p.S770N|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.S770N|PCDH15_uc010qhw.1_Missense_Mutation_p.S733N|PCDH15_uc010qhx.1_Missense_Mutation_p.S699N|PCDH15_uc010qhy.1_Missense_Mutation_p.S775N|PCDH15_uc010qhz.1_Missense_Mutation_p.S770N|PCDH15_uc010qia.1_Missense_Mutation_p.S748N|PCDH15_uc010qib.1_Missense_Mutation_p.S748N|PCDH15_uc001jjw.2_Missense_Mutation_p.S770N	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	770	Extracellular (Potential).|Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGTGTAAATGCTCCCATTGGA	0.403										HNSCC(58;0.16)		
FAM13C	220965	broad.mit.edu	37	10	61029761	61029761	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:61029761T>G	uc001jkn.2	-	8	835	c.701A>C	c.(700-702)AAC>ACC	p.N234T	FAM13C_uc001jko.2_Missense_Mutation_p.N234T|FAM13C_uc010qid.1_Missense_Mutation_p.N151T|FAM13C_uc010qie.1_Missense_Mutation_p.N151T|FAM13C_uc010qif.1_Missense_Mutation_p.N256T|FAM13C_uc001jkp.2_Missense_Mutation_p.N151T	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	234										ovary(2)	2						CAGCAGTGGGTTATCACCATC	0.552												
ANK3	288	broad.mit.edu	37	10	61835974	61835974	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:61835974C>T	uc001jky.2	-	37	4857	c.4665G>A	c.(4663-4665)GCG>GCA	p.A1555A	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1555	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ATGTAGTTGACGCGCCTAATG	0.418												
TET1	80312	broad.mit.edu	37	10	70450964	70450964	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:70450964C>T	uc001jok.3	+	12	6309	c.5804C>T	c.(5803-5805)ACG>ATG	p.T1935M		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1935					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						GAGCCGCTAACGCCTCATCAG	0.552												
SRGN	5552	broad.mit.edu	37	10	70856875	70856875	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:70856875C>T	uc001joz.2	+	2	201	c.115C>T	c.(115-117)CGC>TGC	p.R39C		NM_002727	NP_002718	P10124	SRGN_HUMAN	serglycin precursor	39					apoptosis|biomineral tissue development|maintenance of granzyme B location in T cell secretory granule|maintenance of protease location in mast cell secretory granule|negative regulation of bone mineralization|negative regulation of cytokine secretion|platelet activation|platelet degranulation|protein maturation by peptide bond cleavage	extracellular space|mast cell granule|platelet alpha granule lumen					0						CCAATGGGTGCGCTGCAATCC	0.483												
HK1	3098	broad.mit.edu	37	10	71124621	71124621	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:71124621C>T	uc001jpl.3	+	4	559	c.458C>T	c.(457-459)ACG>ATG	p.T153M	HK1_uc001jpg.3_Missense_Mutation_p.T141M|HK1_uc001jph.3_Missense_Mutation_p.T157M|HK1_uc001jpi.3_Missense_Mutation_p.T157M|HK1_uc001jpj.3_Missense_Mutation_p.T188M|HK1_uc001jpk.3_Missense_Mutation_p.T152M|HK1_uc009xqd.2_Missense_Mutation_p.T31M	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	153	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						GTGGGATTCACGTTTTCTTTT	0.453												
HK1	3098	broad.mit.edu	37	10	71142254	71142254	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:71142254G>A	uc001jpl.3	+	10	1378	c.1277G>A	c.(1276-1278)CGT>CAT	p.R426H	HK1_uc001jpg.3_Missense_Mutation_p.R414H|HK1_uc001jph.3_Missense_Mutation_p.R430H|HK1_uc001jpi.3_Missense_Mutation_p.R430H|HK1_uc001jpj.3_Missense_Mutation_p.R461H|HK1_uc001jpk.3_Missense_Mutation_p.R425H|HK1_uc009xqd.2_Missense_Mutation_p.R304H	NM_000188	NP_000179	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI	426	ATP 1.|Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						TATTCCCGGCGTTTCCACAAG	0.592												
CDH23	64072	broad.mit.edu	37	10	73491893	73491893	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:73491893G>A	uc001jrx.3	+	31	4242	c.3865G>A	c.(3865-3867)GCC>ACC	p.A1289T	CDH23_uc001jrz.2_Missense_Mutation_p.A905T|C10orf105_uc001jsb.1_Intron|CDH23_uc001jsc.1_Missense_Mutation_p.A97T	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1289	Cadherin 12.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CACTGACCAGGCCCCGCCCTT	0.552												
CDH23	64072	broad.mit.edu	37	10	73572286	73572286	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:73572286G>A	uc001jrx.3	+	65	9807	c.9430G>A	c.(9430-9432)GCC>ACC	p.A3144T	CDH23_uc001jsg.3_Missense_Mutation_p.A904T|CDH23_uc001jsh.3_Missense_Mutation_p.A904T|CDH23_uc001jsi.3_Missense_Mutation_p.A904T|CDH23_uc001jsj.3_Missense_Mutation_p.A41T|CDH23_uc010qjr.1_Missense_Mutation_p.A41T	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3144	Cytoplasmic (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGAGCTGGCCGCCCAGGCGGA	0.642												
ZMIZ1	57178	broad.mit.edu	37	10	80968205	80968205	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:80968205C>T	uc001kaf.2	+	6	745	c.173C>T	c.(172-174)ACG>ATG	p.T58M	ZMIZ1_uc001kae.2_Missense_Mutation_p.T58M	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	58					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GGCTGTTTGACGGTGAGTCTG	0.622												
CDHR1	92211	broad.mit.edu	37	10	85968128	85968128	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:85968128G>A	uc001kcv.2	+	11	1162	c.1162G>A	c.(1162-1164)GAC>AAC	p.D388N	CDHR1_uc001kcw.2_Missense_Mutation_p.D388N|CDHR1_uc009xst.2_Missense_Mutation_p.D147N	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	388	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						CAATGACTCCGACCAGGTGTG	0.572												
CDHR1	92211	broad.mit.edu	37	10	85970853	85970853	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:85970853G>A	uc001kcv.2	+	13	1417	c.1417G>A	c.(1417-1419)GAC>AAC	p.D473N	CDHR1_uc001kcw.2_Missense_Mutation_p.D473N|CDHR1_uc009xst.2_Intron|CDHR1_uc001kcx.2_5'Flank	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	473	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						CCCCAAGTTCGACTCCCTCTA	0.592												
LDB3	11155	broad.mit.edu	37	10	88428474	88428474	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:88428474G>T	uc001kdv.2	+	1	49	c.26G>T	c.(25-27)GGG>GTG	p.G9V	LDB3_uc010qml.1_Missense_Mutation_p.G9V|LDB3_uc010qmm.1_Missense_Mutation_p.G9V|LDB3_uc001kdu.2_Missense_Mutation_p.G9V|LDB3_uc009xsz.2_5'UTR|LDB3_uc001kdr.2_Missense_Mutation_p.G9V|LDB3_uc009xsy.2_Missense_Mutation_p.G9V|LDB3_uc001kds.2_Missense_Mutation_p.G9V|LDB3_uc001kdt.2_RNA	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	9	PDZ.					cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						ACCCTGACTGGGCCCGGGCCC	0.642												
MMRN2	79812	broad.mit.edu	37	10	88703011	88703011	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:88703011G>A	uc001kea.2	-	6	1657	c.1530C>T	c.(1528-1530)GAC>GAT	p.D510D	MMRN2_uc010qmn.1_Silent_p.D153D|MMRN2_uc009xtb.2_Silent_p.D467D	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	510						extracellular space				large_intestine(1)	1						CACGCGTGGCGTCCCTCTGGC	0.652												
AGAP11	119385	broad.mit.edu	37	10	88768422	88768422	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:88768422C>T	uc001kee.2	+	12	1617	c.413C>T	c.(412-414)ACA>ATA	p.T138I	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	138	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						TGGCTGAAGACATGGAAAAAG	0.448												
ANKRD22	118932	broad.mit.edu	37	10	90591679	90591679	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:90591679C>T	uc001kfj.3	-	2	494	c.126G>A	c.(124-126)ACG>ACA	p.T42T		NM_144590	NP_653191	Q5VYY1	ANR22_HUMAN	ankyrin repeat domain 22	42	ANK 1.										0		Colorectal(252;0.0163)		Colorectal(12;6.29e-05)|COAD - Colon adenocarcinoma(12;7.69e-05)		AGATCAGGGGCGTGTCTCCAT	0.483												
ACTA2	59	broad.mit.edu	37	10	90701549	90701549	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:90701549G>A	uc001kfp.2	-	5	563	c.447C>T	c.(445-447)CGC>CGT	p.R149R	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Silent_p.R104R|ACTA2_uc001kfq.2_Silent_p.R149R	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	149			R -> C (in AAT6).		response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TACCAGTTGTGCGTCCAGAGG	0.542												
KIF20B	9585	broad.mit.edu	37	10	91483813	91483813	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:91483813T>C	uc001kgs.1	+	14	1887	c.1815T>C	c.(1813-1815)GTT>GTC	p.V605V	KIF20B_uc001kgr.1_Silent_p.V605V|KIF20B_uc001kgt.1_5'UTR	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	605					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						GAGAAGAAGTTACACAGGAGT	0.284												
PCGF5	84333	broad.mit.edu	37	10	92982626	92982626	+	Translation_Start_Site	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:92982626C>T	uc001khh.2	+	2	245	c.-2C>T	c.(-4-0)CACGA>CATGA		PCGF5_uc001khg.2_RNA|PCGF5_uc010qnk.1_Translation_Start_Site|PCGF5_uc001khi.2_Translation_Start_Site	NM_032373	NP_115749	Q86SE9	PCGF5_HUMAN	polycomb group ring finger 5						regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|PcG protein complex	zinc ion binding			lung(1)	1						TCACTAGCCACGAATGGCTAC	0.458												
BTAF1	9044	broad.mit.edu	37	10	93744029	93744029	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:93744029C>T	uc001khr.2	+	19	2393	c.2295C>T	c.(2293-2295)GAC>GAT	p.D765D	BTAF1_uc001khs.1_Silent_p.D435D|BTAF1_uc001kht.1_Silent_p.D203D	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	765					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TATATTATGACGAAATTGCCG	0.348												
MYOF	26509	broad.mit.edu	37	10	95069835	95069835	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:95069835C>T	uc001kin.2	-	53	6212	c.6089G>A	c.(6088-6090)GGC>GAC	p.G2030D	MYOF_uc001kio.2_Missense_Mutation_p.G2017D|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	2030	Helical; (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GAACAGCAAGCCGATGATGAC	0.542												
PDE6C	5146	broad.mit.edu	37	10	95394529	95394529	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:95394529C>T	uc001kiu.3	+	9	1272	c.1134C>T	c.(1132-1134)GAC>GAT	p.D378D		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	378	GAF 2.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				GACCTGTAGACGAAACTGGTT	0.303												
SORBS1	10580	broad.mit.edu	37	10	97096789	97096789	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:97096789C>T	uc001kkp.2	-	28	3173	c.3128G>A	c.(3127-3129)CGT>CAT	p.R1043H	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.R997H|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1043					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		TGGGGTGGGACGATCTGACCA	0.562												
ALDH18A1	5832	broad.mit.edu	37	10	97397115	97397115	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:97397115G>A	uc001kkz.2	-	4	624	c.382C>T	c.(382-384)CGC>TGC	p.R128C	ALDH18A1_uc001kky.2_Missense_Mutation_p.R128C|ALDH18A1_uc010qog.1_Missense_Mutation_p.R17C|ALDH18A1_uc010qoh.1_Intron	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	128	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	ATCTCATGGCGCAAGCGTTGT	0.547												
SLIT1	6585	broad.mit.edu	37	10	98764573	98764573	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:98764573G>A	uc001kmw.2	-	33	3839	c.3587C>T	c.(3586-3588)ACG>ATG	p.T1196M		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1196	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GTCCTCTGCCGTGGAGACCTG	0.602												
RRP12	23223	broad.mit.edu	37	10	99141494	99141494	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:99141494G>A	uc001knf.2	-	11	1437	c.1298C>T	c.(1297-1299)ACT>ATT	p.T433I	RRP12_uc009xvm.2_Missense_Mutation_p.T151I|RRP12_uc010qou.1_Missense_Mutation_p.T372I|RRP12_uc009xvn.2_Missense_Mutation_p.T333I	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	433						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CGTAGCAGCAGTCAGCACTTG	0.587												
DHDPSL	112817	broad.mit.edu	37	10	99358872	99358872	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:99358872G>A	uc001kny.2	+	3	726	c.367G>A	c.(367-369)GTC>ATC	p.V123I	DHDPSL_uc001knx.2_Missense_Mutation_p.V123I|DHDPSL_uc001knz.2_Intron|PI4K2A_uc010qoy.1_Intron	NM_138413	NP_612422	Q86XE5	HOGA1_HUMAN	DHDPS-like protein isoform 1	123					glyoxylate catabolic process	mitochondrion	4-hydroxy-2-oxoglutarate aldolase activity				0						GGAGATGACCGTCAGCATGGC	0.627												
CRTAC1	55118	broad.mit.edu	37	10	99695979	99695979	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:99695979G>A	uc001kou.1	-	3	725	c.369C>T	c.(367-369)GAC>GAT	p.D123D	CRTAC1_uc001kov.2_Silent_p.D112D|CRTAC1_uc001kot.1_Translation_Start_Site	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	123	FG-GAP 2; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		GGCCGTCCCCGTCGATGTCGC	0.637												
CNNM1	26507	broad.mit.edu	37	10	101090324	101090324	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:101090324C>T	uc001kpp.3	+	1	1469	c.1180C>T	c.(1180-1182)CGG>TGG	p.R394W	CNNM1_uc009xwe.2_Missense_Mutation_p.R394W|CNNM1_uc010qpi.1_Missense_Mutation_p.R394W|CNNM1_uc009xwf.2_Missense_Mutation_p.R394W	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	394	DUF21.				ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		CTTCTACACGCGGGAGAAGTT	0.647												
LBX1	10660	broad.mit.edu	37	10	102987489	102987489	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:102987489C>T	uc001ksx.2	-	2	529	c.384G>A	c.(382-384)TCG>TCA	p.S128S	uc010qpy.1_5'Flank	NM_006562	NP_006553	P52954	LBX1_HUMAN	ladybird homeobox 1	128	Homeobox.				muscle organ development		sequence-specific DNA binding				0		Colorectal(252;0.234)		Epithelial(162;3.22e-09)|all cancers(201;1.79e-07)		AGGCCGTGCGCGACTTTCGCC	0.587												
POLL	27343	broad.mit.edu	37	10	103340084	103340084	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:103340084G>A	uc001ktg.1	-	7	2050	c.1284C>T	c.(1282-1284)GTC>GTT	p.V428V	DPCD_uc010qpz.1_Intron|POLL_uc001ktd.1_Silent_p.V101V|POLL_uc001kte.1_Silent_p.V120V|POLL_uc001kth.1_Silent_p.V153V|POLL_uc001kti.1_Silent_p.V428V|POLL_uc001ktj.1_Silent_p.V428V|POLL_uc001ktf.2_Silent_p.V336V|POLL_uc001ktk.1_Silent_p.V167V|POLL_uc010qqa.1_Silent_p.V167V|POLL_uc010qqb.1_RNA|POLL_uc001ktm.2_Silent_p.V428V|POLL_uc001ktl.2_Silent_p.V340V|POLL_uc010qqc.1_Silent_p.V120V	NM_013274	NP_037406	Q9UGP5	DPOLL_HUMAN	DNA-directed DNA polymerase lambda	428	Involved in primer binding (By similarity).				DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding				0		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		TGAGCACGTCGACATCACCAC	0.582								DNA_polymerases_(catalytic_subunits)				
CNNM2	54805	broad.mit.edu	37	10	104679333	104679333	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:104679333C>T	uc001kwm.2	+	1	1220	c.1096C>T	c.(1096-1098)CGG>TGG	p.R366W	CNNM2_uc001kwn.2_Missense_Mutation_p.R366W|CNNM2_uc001kwl.2_Missense_Mutation_p.R366W	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	366	DUF21.				ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CATCTGCTCCCGGCATGGCCT	0.617												
SH3PXD2A	9644	broad.mit.edu	37	10	105361883	105361883	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:105361883C>T	uc001kxj.1	-	14	3148	c.3008G>A	c.(3007-3009)CGC>CAC	p.R1003H	SH3PXD2A_uc010qqr.1_Intron|SH3PXD2A_uc010qqs.1_Missense_Mutation_p.R838H|SH3PXD2A_uc010qqt.1_Missense_Mutation_p.R880H|SH3PXD2A_uc009xxn.1_Missense_Mutation_p.R838H|SH3PXD2A_uc010qqu.1_Missense_Mutation_p.R946H	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	1031					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		TTCGGCCAGGCGGCCCTTGGC	0.682												
COL17A1	1308	broad.mit.edu	37	10	105824282	105824282	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:105824282G>A	uc001kxr.2	-	10	849	c.680C>T	c.(679-681)GCG>GTG	p.A227V	COL17A1_uc010qqv.1_Missense_Mutation_p.A211V|COL17A1_uc009xxp.1_Missense_Mutation_p.A227V	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	227	Cytoplasmic (Potential).|Nonhelical region (NC16).|Necessary for interaction with DST and for the recruitment of DST to hemidesmosome.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGAGGACCCCGCGGGCAGGGT	0.587												
TDRD1	56165	broad.mit.edu	37	10	115963151	115963151	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:115963151C>T	uc001lbg.1	+	8	959	c.806C>T	c.(805-807)ACG>ATG	p.T269M	TDRD1_uc001lbf.2_Missense_Mutation_p.T260M|TDRD1_uc001lbh.1_Missense_Mutation_p.T260M|TDRD1_uc001lbi.1_Missense_Mutation_p.T260M|TDRD1_uc010qsc.1_Translation_Start_Site|TDRD1_uc001lbj.2_Translation_Start_Site	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	269					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TGAAAGGGTACGGTTACCGAA	0.348												
ATRNL1	26033	broad.mit.edu	37	10	117045787	117045787	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:117045787T>A	uc001lcg.2	+	15	2681	c.2295T>A	c.(2293-2295)AGT>AGA	p.S765R		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	765	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TCAATTCCAGTAGAGAAAACT	0.333												
VAX1	11023	broad.mit.edu	37	10	118897444	118897444	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:118897444C>T	uc009xyx.2	-	1	369	c.124G>A	c.(124-126)GCC>ACC	p.A42T	VAX1_uc001ldb.1_Missense_Mutation_p.A42T	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	42						nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)		TTGAGGAAGGCGGCTGGGAGG	0.642												
INPP5F	22876	broad.mit.edu	37	10	121557041	121557041	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:121557041T>G	uc001leo.2	+	8	1103	c.937T>G	c.(937-939)TTG>GTG	p.L313V		NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	313	SAC.						phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		GACTGAGCAGTTGATTCATGT	0.413												
FGFR2	2263	broad.mit.edu	37	10	123325038	123325038	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:123325038G>A	uc010qtk.1	-	3	937	c.290C>T	c.(289-291)GCC>GTC	p.A97V	FGFR2_uc010qtg.1_Missense_Mutation_p.A97V|FGFR2_uc010qth.1_Intron|FGFR2_uc010qti.1_Intron|FGFR2_uc010qtj.1_Missense_Mutation_p.A97V|FGFR2_uc010qtl.1_Missense_Mutation_p.A97V|FGFR2_uc010qtm.1_Intron|FGFR2_uc001lfl.3_Missense_Mutation_p.A97V|FGFR2_uc001lfm.2_Intron|FGFR2_uc001lfn.3_Intron|FGFR2_uc010qtn.1_Missense_Mutation_p.A116V|FGFR2_uc010qto.1_Intron|FGFR2_uc001lfo.1_Missense_Mutation_p.A116V|FGFR2_uc010qtp.1_Missense_Mutation_p.A116V|FGFR2_uc010qtq.1_Missense_Mutation_p.A116V	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	97	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.A97T(1)		endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TCTAGGCGTGGCGCCCTTTAT	0.527		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome			
HMX3	340784	broad.mit.edu	37	10	124896865	124896865	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:124896865G>A	uc010quc.1	+	2	692	c.692G>A	c.(691-693)CGC>CAC	p.R231H		NM_001105574	NP_001099044	A6NHT5	HMX3_HUMAN	H6 family homeobox 3	231	Homeobox.				cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.122)|COAD - Colon adenocarcinoma(40;0.141)		AAGAAGACGCGCACAGTCTTC	0.662												
CTBP2	1488	broad.mit.edu	37	10	126727703	126727703	+	Translation_Start_Site	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:126727703G>A	uc009yak.2	-	3	208	c.-79C>T	c.(-81--77)CACGC>CATGC		CTBP2_uc009yal.2_Translation_Start_Site|CTBP2_uc001lif.3_Translation_Start_Site|CTBP2_uc001lih.3_Translation_Start_Site	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1						negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		AGGAGTCTGCGTGCATGACGC	0.488												
DOCK1	1793	broad.mit.edu	37	10	128836060	128836060	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:128836060G>A	uc001ljt.2	+	19	1991	c.1927G>A	c.(1927-1929)GAT>AAT	p.D643N	DOCK1_uc010qun.1_Missense_Mutation_p.D664N	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	643	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GATGAAAGTCGATGGTGGTGA	0.438												
FAM196A	642938	broad.mit.edu	37	10	128974539	128974539	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:128974539G>A	uc001lju.1	-	1	162	c.121C>T	c.(121-123)CGG>TGG	p.R41W	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Missense_Mutation_p.R41W|FAM196A_uc001ljv.1_Missense_Mutation_p.R41W|FAM196A_uc009yap.1_Missense_Mutation_p.R41W	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	41										ovary(2)	2						GCTTTGTTCCGTTTTTTAATC	0.577												
FAM196A	642938	broad.mit.edu	37	10	128974569	128974569	+	Missense_Mutation	SNP	C	C	T	rs150536495		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:128974569C>T	uc001lju.1	-	1	132	c.91G>A	c.(91-93)GCC>ACC	p.A31T	DOCK1_uc001ljt.2_Intron|DOCK1_uc010qun.1_Intron|FAM196A_uc010quo.1_Missense_Mutation_p.A31T|FAM196A_uc001ljv.1_Missense_Mutation_p.A31T|FAM196A_uc009yap.1_Missense_Mutation_p.A31T	NM_001039762	NP_001034851	Q6ZSG2	F196A_HUMAN	hypothetical protein LOC642938	31										ovary(2)	2						GGGTCCAGGGCGTATTTCATC	0.552												
NKX6-2	84504	broad.mit.edu	37	10	134598438	134598438	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:134598438G>A	uc001llr.2	-	3	901	c.816C>T	c.(814-816)GGC>GGT	p.G272G		NM_177400	NP_796374	Q9C056	NKX62_HUMAN	NK6 transcription factor related, locus 2	272						nucleus	sequence-specific DNA binding transcription factor activity				0		all_cancers(35;2.79e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0584)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;4.06e-05)|Epithelial(32;5.53e-05)|all cancers(32;5.99e-05)		CGTCCCCCGCGCCGCCGCCGC	0.667												
B4GALNT4	338707	broad.mit.edu	37	11	375665	375665	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:375665G>A	uc001lpb.2	+	10	886	c.877G>A	c.(877-879)GTG>ATG	p.V293M		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	293	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GATGGACCACGTGGCGCACGT	0.652												
ANO9	338440	broad.mit.edu	37	11	418466	418466	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:418466G>A	uc001lpi.2	-	23	2339	c.2254C>T	c.(2254-2256)CAG>TAG	p.Q752*	SIGIRR_uc001lpf.2_5'Flank|SIGIRR_uc001lpe.1_5'Flank|ANO9_uc001lph.2_Nonsense_Mutation_p.Q445*|ANO9_uc010qvv.1_Nonsense_Mutation_p.Q608*	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	752	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CCCAGCCTCTGCCTTCCATGC	0.627												
PTDSS2	81490	broad.mit.edu	37	11	479107	479107	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:479107C>T	uc001lpj.2	+	4	566	c.390C>T	c.(388-390)TGC>TGT	p.C130C	PTDSS2_uc009ybv.1_Silent_p.C130C	NM_030783	NP_110410	Q9BVG9	PTSS2_HUMAN	phosphatidylserine synthase 2	130	Helical; (Potential).					integral to membrane					0		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;2.76e-26)|Epithelial(43;2.56e-25)|OV - Ovarian serous cystadenocarcinoma(40;7.54e-20)|BRCA - Breast invasive adenocarcinoma(625;8.76e-05)|Lung(200;0.0407)|LUSC - Lung squamous cell carcinoma(625;0.0735)	Phosphatidylserine(DB00144)	TTTGGCTCTGCGTGAGTGTGG	0.562												
PHRF1	57661	broad.mit.edu	37	11	598418	598418	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:598418G>A	uc001lqe.2	+	9	1071	c.940G>A	c.(940-942)GAG>AAG	p.E314K	PHRF1_uc010qwc.1_Missense_Mutation_p.E314K|PHRF1_uc010qwd.1_Missense_Mutation_p.E313K|PHRF1_uc010qwe.1_Missense_Mutation_p.E310K|PHRF1_uc009ybz.1_Missense_Mutation_p.E105K	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	314	Arg-rich.						RNA polymerase binding|zinc ion binding				0						TGAAGCCATCGAGGCTGTGGC	0.657												
PHRF1	57661	broad.mit.edu	37	11	608437	608437	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:608437G>A	uc001lqe.2	+	14	3112	c.2981G>A	c.(2980-2982)CGC>CAC	p.R994H	PHRF1_uc010qwc.1_Missense_Mutation_p.R993H|PHRF1_uc010qwd.1_Missense_Mutation_p.R992H|PHRF1_uc010qwe.1_Missense_Mutation_p.R990H|PHRF1_uc009ybz.1_Missense_Mutation_p.R784H|PHRF1_uc009yca.1_RNA	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	994	Arg-rich.						RNA polymerase binding|zinc ion binding				0						TCCCGGTCCCGCTCCACATCC	0.677												
DEAF1	10522	broad.mit.edu	37	11	686948	686948	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:686948G>A	uc001lqq.1	-	5	1407	c.714C>T	c.(712-714)ACC>ACT	p.T238T	DEAF1_uc009ycf.1_RNA	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	238	SAND.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		CCTCAAACTCGGTGGGACTGT	0.602												
MUC5B	727897	broad.mit.edu	37	11	1154250	1154250	+	Silent	SNP	C	C	T	rs79836765		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:1154250C>T	uc009ycr.1	+	3	222	c.96C>T	c.(94-96)TCC>TCT	p.S32S		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ATGGCTCCTCCGAATCCAGCT	0.657												
CARS	833	broad.mit.edu	37	11	3062131	3062131	+	Silent	SNP	G	G	A	rs61737270	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:3062131G>A	uc001lxh.2	-	3	275	c.201C>T	c.(199-201)CAC>CAT	p.H67H	CARS_uc001lxe.2_Silent_p.H57H|CARS_uc001lxf.2_Silent_p.H150H|CARS_uc001lxg.2_Silent_p.H67H|CARS_uc010qxo.1_Silent_p.H150H|CARS_uc010qxp.1_Silent_p.H80H|uc001lxi.1_RNA	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	67	HIGH region.				cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	CCTACCTGGCGTGCCCCATGT	0.537			T	ALK	ALCL							
OSBPL5	114879	broad.mit.edu	37	11	3140844	3140844	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:3140844G>A	uc001lxk.2	-	7	782	c.624C>T	c.(622-624)AGC>AGT	p.S208S	OSBPL5_uc010qxq.1_Silent_p.S119S|OSBPL5_uc009ydw.2_Silent_p.S140S|OSBPL5_uc001lxl.2_Silent_p.S140S|OSBPL5_uc009ydx.2_Silent_p.S232S	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	208	PH.				cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TGGAGCCCACGCTCTCACCTT	0.627												
NUP98	4928	broad.mit.edu	37	11	3697469	3697469	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:3697469T>C	uc001lyh.2	-	33	5614	c.5323A>G	c.(5323-5325)ATG>GTG	p.M1775V	NUP98_uc001lyi.2_Missense_Mutation_p.M1701V|NUP98_uc001lyg.2_Missense_Mutation_p.M740V	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1792					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TCCTCAGGCATGGGAAGCCGG	0.587			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML							
OR51F1	256892	broad.mit.edu	37	11	4790804	4790804	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:4790804C>T	uc010qyl.1	-	1	344	c.344G>A	c.(343-345)GGA>GAA	p.G115E		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	115						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		CACCAGCACTCCAGATTCCAT	0.428												
OR51G1	79324	broad.mit.edu	37	11	4945161	4945161	+	Missense_Mutation	SNP	C	C	T	rs145607331	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:4945161C>T	uc010qyr.1	-	1	409	c.409G>A	c.(409-411)GTC>ATC	p.V137I		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGTGTCAGGACGGTGGAGTCA	0.512												
OR51V1	283111	broad.mit.edu	37	11	5221347	5221347	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:5221347C>T	uc010qyz.1	-	1	584	c.584G>A	c.(583-585)CGC>CAC	p.R195H		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACAGGCTAAGCGGAGAAGATC	0.403												
FAM160A2	84067	broad.mit.edu	37	11	6244371	6244371	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:6244371A>G	uc001mcl.3	-	4	1234	c.875T>C	c.(874-876)CTG>CCG	p.L292P	FAM160A2_uc001mck.3_Missense_Mutation_p.L292P|FAM160A2_uc001mcm.2_Missense_Mutation_p.L292P	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	292					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						TGGCACTCCCAGCCAGTCTTC	0.542												
SMPD1	6609	broad.mit.edu	37	11	6413002	6413002	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:6413002C>T	uc001mcw.2	+	2	881	c.707C>T	c.(706-708)CCG>CTG	p.P236L	SMPD1_uc001mcv.1_Intron|SMPD1_uc009yex.2_RNA|SMPD1_uc001mcx.2_Missense_Mutation_p.P236L|SMPD1_uc009yew.2_Missense_Mutation_p.P235L	NM_000543	NP_000534	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid	234					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	TCTGGCCTGCCGCCCGCATCC	0.657												
APBB1	322	broad.mit.edu	37	11	6432180	6432180	+	Missense_Mutation	SNP	C	C	T	rs139345068		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:6432180C>T	uc001mdb.1	-	2	498	c.398G>A	c.(397-399)CGA>CAA	p.R133Q	APBB1_uc001mdc.1_Missense_Mutation_p.R133Q|APBB1_uc010rah.1_Intron	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	133					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		GCCAGGTCCTCGTAGGCCTCG	0.433												
OR10A2	341276	broad.mit.edu	37	11	6891024	6891024	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:6891024A>G	uc001meu.1	+	1	39	c.39A>G	c.(37-39)TTA>TTG	p.L13L		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	13	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TACAGTCATTACTCTTTCTGA	0.468												
OR10A2	341276	broad.mit.edu	37	11	6891030	6891030	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:6891030T>C	uc001meu.1	+	1	45	c.45T>C	c.(43-45)TTT>TTC	p.F15F		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	15	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CATTACTCTTTCTGACATTTC	0.453												
OVCH2	341277	broad.mit.edu	37	11	7716409	7716409	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:7716409G>T	uc010rbf.1	-	13	1293	c.1293C>A	c.(1291-1293)TGC>TGA	p.C431*		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		TTAAGTAACTGCAACCTGAAT	0.398											OREG0020725	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
NRIP3	56675	broad.mit.edu	37	11	9009687	9009687	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:9009687T>C	uc001mhg.2	-	2	431	c.317A>G	c.(316-318)GAC>GGC	p.D106G	NRIP3_uc010rbu.1_Missense_Mutation_p.D106G	NM_020645	NP_065696	Q9NQ35	NRIP3_HUMAN	nuclear receptor interacting protein 3	106					proteolysis		aspartic-type endopeptidase activity				0				Epithelial(150;4.77e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0241)		CAAAATCATGTCATCCTCCTC	0.493												
DENND5A	23258	broad.mit.edu	37	11	9191462	9191462	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:9191462G>A	uc001mhl.2	-	10	2347	c.2092C>T	c.(2092-2094)CGG>TGG	p.R698W	DENND5A_uc001mhk.2_Missense_Mutation_p.R41W|DENND5A_uc010rbw.1_Missense_Mutation_p.R698W|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	698										liver(1)	1						CGATCTTTCCGCCTCCACTGG	0.438												
RPS13	6207	broad.mit.edu	37	11	17098745	17098745	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:17098745C>T	uc001mmp.2	-	3	153	c.121G>A	c.(121-123)GCC>ACC	p.A41T		NM_001017	NP_001008	P62277	RS13_HUMAN	ribosomal protein S13	41					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome				0						CCCTTCTTGGCCAGTTTGTAA	0.483												
MYOD1	4654	broad.mit.edu	37	11	17742486	17742486	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:17742486G>A	uc001mni.2	+	2	888	c.668G>A	c.(667-669)CGG>CAG	p.R223Q		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	223					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3						gcccggcggcggAACTGCTAC	0.537												
SPTY2D1	144108	broad.mit.edu	37	11	18633072	18633072	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:18633072C>T	uc001moy.2	-	5	2132	c.1916G>A	c.(1915-1917)CGT>CAT	p.R639H		NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	639										breast(1)	1						TTCCATGTAACGTAAGGCATA	0.323												
MRGPRX1	259249	broad.mit.edu	37	11	18955510	18955510	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:18955510G>A	uc001mpg.2	-	1	1040	c.822C>T	c.(820-822)TTC>TTT	p.F274F		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	274	Helical; Name=7; (Potential).				acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						AGGAGCCCACGAAGAAGTAAA	0.512												
PAMR1	25891	broad.mit.edu	37	11	35456304	35456304	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:35456304C>T	uc001mwg.2	-	10	1425	c.1382G>A	c.(1381-1383)CGC>CAC	p.R461H	PAMR1_uc001mwf.2_Missense_Mutation_p.R478H|PAMR1_uc010rew.1_Missense_Mutation_p.R350H|PAMR1_uc010rex.1_Missense_Mutation_p.R421H	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	461	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						CCACGGCCAGCGCAACCCTTG	0.552												
API5	8539	broad.mit.edu	37	11	43351532	43351532	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:43351532G>A	uc010rfh.1	+	10	1318	c.1145G>A	c.(1144-1146)CGG>CAG	p.R382Q	API5_uc010rfg.1_Missense_Mutation_p.R371Q|API5_uc001mxf.2_Missense_Mutation_p.R382Q|API5_uc010rfi.1_Missense_Mutation_p.R328Q|API5_uc001mxg.2_Missense_Mutation_p.R256Q	NM_001142930	NP_001136402	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5 isoform a	382	Leucine-zipper.				anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TACTTTGCACGGGGCCTGCAA	0.368												
ACCS	84680	broad.mit.edu	37	11	44102762	44102762	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:44102762C>A	uc009yks.1	+	12	1147	c.1003C>A	c.(1003-1005)CTG>ATG	p.L335M	EXT2_uc010rfo.1_Intron|ACCS_uc001mxx.2_Missense_Mutation_p.L335M	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	335							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						CTTTGGCACGCTGTACACAGA	0.627												
CHST1	8534	broad.mit.edu	37	11	45671251	45671251	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:45671251C>T	uc001mys.1	-	4	1894	c.1223G>A	c.(1222-1224)CGC>CAC	p.R408H		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	408	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		CGAGAAGGGGCGGAAGTCCCG	0.632												
AMBRA1	55626	broad.mit.edu	37	11	46564257	46564257	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:46564257G>A	uc010rgu.1	-	7	1670	c.1310C>T	c.(1309-1311)CCG>CTG	p.P437L	AMBRA1_uc010rgt.1_Missense_Mutation_p.P3L|AMBRA1_uc009ylc.1_Missense_Mutation_p.P437L|AMBRA1_uc001ncu.1_Missense_Mutation_p.P347L|AMBRA1_uc001ncv.2_Missense_Mutation_p.P347L|AMBRA1_uc001ncw.2_Missense_Mutation_p.P347L|AMBRA1_uc001ncx.2_Missense_Mutation_p.P437L	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	437					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GGTTCTGGGCGGGGGCATGGA	0.567												
AMBRA1	55626	broad.mit.edu	37	11	46568814	46568814	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:46568814T>G	uc010rgu.1	-	4	587	c.227A>C	c.(226-228)AAT>ACT	p.N76T	AMBRA1_uc009ylc.1_Missense_Mutation_p.N76T|AMBRA1_uc001ncu.1_Missense_Mutation_p.N76T|AMBRA1_uc001ncv.2_Missense_Mutation_p.N76T|AMBRA1_uc001ncw.2_Missense_Mutation_p.N76T|AMBRA1_uc001ncx.2_Missense_Mutation_p.N76T	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	76	WD 1.				autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AATATAGATATTATGGTTCAC	0.448												
OR4B1	119765	broad.mit.edu	37	11	48238681	48238681	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:48238681T>C	uc010rhs.1	+	1	320	c.320T>C	c.(319-321)GTT>GCT	p.V107A		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						TTCTTTGGGGTTGCTGAGATC	0.423												
OR4X1	390113	broad.mit.edu	37	11	48286043	48286043	+	Missense_Mutation	SNP	G	G	A	rs61915300		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:48286043G>A	uc010rht.1	+	1	631	c.631G>A	c.(631-633)GTG>ATG	p.V211M		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3						CAGTTTCTTCGTGCTGATGGC	0.557												
OR8K5	219453	broad.mit.edu	37	11	55927379	55927379	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:55927379G>A	uc010rja.1	-	1	415	c.415C>T	c.(415-417)CGA>TGA	p.R139*		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				TGACACAGTCGCTGAGACATA	0.403												
OR8H1	219469	broad.mit.edu	37	11	56058017	56058017	+	Silent	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:56058017A>T	uc010rje.1	-	1	522	c.522T>A	c.(520-522)CGT>CGA	p.R174R		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					AGAAAAAGTGACGAACTACAT	0.448												
GLYATL1	92292	broad.mit.edu	37	11	58723451	58723451	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:58723451G>A	uc001nnf.2	+	8	1236	c.860G>A	c.(859-861)TGT>TAT	p.C287Y	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.C318Y|GLYATL1_uc001nni.1_Missense_Mutation_p.C287Y|GLYATL1_uc001nnj.1_Missense_Mutation_p.C287Y			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	287						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	GAGGCCTCCTGTGAGTGGCAC	0.423												
PATL1	219988	broad.mit.edu	37	11	59406604	59406604	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:59406604T>C	uc001noe.3	-	18	2351	c.2208A>G	c.(2206-2208)CCA>CCG	p.P736P		NM_152716	NP_689929	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog	736	Region C.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1						GTATAGAGATTGGCTTGGCCA	0.478												
AHNAK	79026	broad.mit.edu	37	11	62285596	62285596	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:62285596G>A	uc001ntl.2	-	5	16593	c.16293C>T	c.(16291-16293)GGC>GGT	p.G5431G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5431					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTCAGTTCGCCAGAAACCT	0.527												
TUT1	64852	broad.mit.edu	37	11	62349015	62349015	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:62349015G>A	uc001nto.2	-	3	584	c.546C>T	c.(544-546)CCC>CCT	p.P182P		NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	144					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						GGTGACTGTCGGGGGCCGCTC	0.652												
TTC9C	283237	broad.mit.edu	37	11	62496491	62496491	+	Silent	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:62496491G>C	uc001nuy.2	+	1	540	c.171G>C	c.(169-171)CCG>CCC	p.P57P	HNRNPUL2_uc001nuu.1_5'Flank|HNRNPUL2_uc001nuw.2_5'Flank|TTC9C_uc001nux.2_Silent_p.P190P	NM_173810	NP_776171	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	57							binding			ovary(1)|pancreas(1)	2						CTCAGGGCCCGGCCCTCACGC	0.547												
MARK2	2011	broad.mit.edu	37	11	63676573	63676573	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:63676573A>G	uc001nxw.2	+	19	2810	c.2231A>G	c.(2230-2232)GAC>GGC	p.D744G	MARK2_uc001nxx.2_Missense_Mutation_p.D675G|MARK2_uc001nxy.2_Missense_Mutation_p.D665G|MARK2_uc001nxv.3_Missense_Mutation_p.D680G|MARK2_uc001nxz.3_Missense_Mutation_p.D701G|MARK2_uc009yoy.2_Missense_Mutation_p.D655G	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	744	KA1.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						GGCCACGAGGACTTCGTGCAG	0.597												
NAALADL1	10004	broad.mit.edu	37	11	64813303	64813303	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:64813303C>T	uc001ocn.2	-	17	2043	c.2027G>A	c.(2026-2028)CGC>CAC	p.R676H	NAALADL1_uc010rnw.1_Missense_Mutation_p.R152H|NAALADL1_uc009ypz.2_RNA	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	676	Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						CCTGTAGTAGCGTTCCTCTGG	0.612												
PCNXL3	399909	broad.mit.edu	37	11	65392970	65392970	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:65392970C>T	uc001oey.2	+	18	3124	c.3124C>T	c.(3124-3126)CGC>TGC	p.R1042C	PCNXL3_uc009yqn.2_Missense_Mutation_p.R2C|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1042						integral to membrane					0						GGACAAGATGCGCCAGTCGGT	0.701												
DKFZp761E198	91056	broad.mit.edu	37	11	65547392	65547392	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:65547392A>G	uc001ofo.3	-	1	431	c.401T>C	c.(400-402)CTC>CCC	p.L134P		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	134	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		GCGCAAAGCGAGGGCCAGCAA	0.692												
GAL3ST3	89792	broad.mit.edu	37	11	65810630	65810630	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:65810630C>T	uc001ogv.2	-	2	804	c.644G>A	c.(643-645)CGC>CAC	p.R215H	GAL3ST3_uc001ogw.2_Missense_Mutation_p.R215H	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	215	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						GCGCGGGCTGCGCTCATTGTC	0.667												
PACS1	55690	broad.mit.edu	37	11	65998373	65998373	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:65998373G>A	uc001oha.1	+	13	1722	c.1588G>A	c.(1588-1590)GAC>AAC	p.D530N	PACS1_uc010rou.1_Missense_Mutation_p.D66N	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	530					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						CAACAGTTCCGACAGCGAGCG	0.617												
RIN1	9610	broad.mit.edu	37	11	66099763	66099763	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:66099763C>T	uc001ohn.1	-	10	2463	c.2336G>A	c.(2335-2337)CGG>CAG	p.R779Q	RIN1_uc010roy.1_Missense_Mutation_p.R410Q|RIN1_uc009yrd.1_Missense_Mutation_p.R472Q|RIN1_uc010roz.1_Missense_Mutation_p.R674Q|RIN1_uc010rpa.1_Missense_Mutation_p.R613Q	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	779					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						CTCTGCTGCCCGGCTTCCCTC	0.622												
DPP3	10072	broad.mit.edu	37	11	66249741	66249741	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:66249741C>T	uc001oig.1	+	2	132	c.70C>T	c.(70-72)CGC>TGC	p.R24C	DPP3_uc001oif.1_Missense_Mutation_p.R24C|DPP3_uc010rpe.1_Missense_Mutation_p.R43C	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	24					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TGAGGCCTTCCGCCTGCTGTC	0.642												
RBM14	10432	broad.mit.edu	37	11	66393068	66393068	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:66393068C>T	uc001oit.2	+	2	1860	c.1721C>T	c.(1720-1722)CCG>CTG	p.P574L	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	574					DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						AGCACCCCGCCGCCCTATGAG	0.662												
ADRBK1	156	broad.mit.edu	37	11	67051736	67051736	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:67051736C>T	uc009yrn.1	+	18	1812	c.1546C>T	c.(1546-1548)CGG>TGG	p.R516W	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	516	AGC-kinase C-terminal.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	CATCTCGGAGCGGTGGCAGCA	0.592												
LRP5	4041	broad.mit.edu	37	11	68205952	68205952	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:68205952A>C	uc001ont.2	+	20	4225	c.4150A>C	c.(4150-4152)AGC>CGC	p.S1384R	LRP5_uc009ysg.2_Missense_Mutation_p.S794R	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1384	Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CCCGGCCCACAGCAGTGCCAT	0.592												
MYEOV	26579	broad.mit.edu	37	11	69063312	69063312	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:69063312G>A	uc001oov.2	+	3	845	c.395G>A	c.(394-396)CGG>CAG	p.R132Q	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.R132Q|MYEOV_uc001oow.2_Missense_Mutation_p.R74Q	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	132											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		GACGTGTCCCGGGCCAGGAGG	0.617												
LRTOMT	220074	broad.mit.edu	37	11	71806464	71806464	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:71806464C>T	uc001orr.2	+	6	855	c.477C>T	c.(475-477)TTC>TTT	p.F159F	LRTOMT_uc009ysz.2_RNA|LRTOMT_uc010rqt.1_3'UTR|LRTOMT_uc010rqu.1_Silent_p.F141F|LRTOMT_uc009yta.2_RNA|LRTOMT_uc010rqv.1_Intron|LRTOMT_uc010rqw.1_Intron|LRTOMT_uc001ors.3_Intron|LRTOMT_uc010rqs.1_Intron	NM_145309	NP_660352	Q96E66	LRC51_HUMAN	leucine rich transmembrane and	159	LRRCT.					cytoplasm					0						TCACCACGTTCGACTTCAGTG	0.567												
FOLR2	2350	broad.mit.edu	37	11	71931995	71931995	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:71931995T>G	uc009ytd.2	+	3	401	c.232T>G	c.(232-234)TTT>GTT	p.F78V	FOLR2_uc009yte.2_Missense_Mutation_p.F78V|FOLR2_uc001ose.3_Missense_Mutation_p.F78V|FOLR2_uc009ytf.2_Missense_Mutation_p.F78V	NM_001113534	NP_001107006	P14207	FOLR2_HUMAN	folate receptor 2 precursor	78					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(2)|ovary(1)	3					Folic Acid(DB00158)	CCTGTACAACTTTAACTGGGA	0.602												
C2CD3	26005	broad.mit.edu	37	11	73785348	73785348	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:73785348G>A	uc001ouu.2	-	24	5128	c.4901C>T	c.(4900-4902)ACG>ATG	p.T1634M	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1634	C2 2.					centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					GACTGCAAACGTTCCATCCAA	0.562												
GDPD5	81544	broad.mit.edu	37	11	75146602	75146602	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:75146602G>A	uc001owo.3	-	18	2305	c.1768C>T	c.(1768-1770)CGA>TGA	p.R590*	GDPD5_uc001owp.3_Nonsense_Mutation_p.R590*|GDPD5_uc001own.3_Nonsense_Mutation_p.R345*|GDPD5_uc009yuc.2_Nonsense_Mutation_p.R452*|GDPD5_uc009yud.2_Nonsense_Mutation_p.R471*	NM_030792	NP_110419	Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain	590	Cytoplasmic (Potential).				glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			ovary(1)	1						CCACCCCCTCGGGGGCCCACA	0.577												
CCDC81	60494	broad.mit.edu	37	11	86133684	86133684	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:86133684G>A	uc001pbx.1	+	15	2314	c.1886G>A	c.(1885-1887)CGC>CAC	p.R629H	CCDC81_uc001pbw.1_Missense_Mutation_p.R539H|CCDC81_uc010rtq.1_Missense_Mutation_p.R412H|CCDC81_uc001pby.1_Missense_Mutation_p.R364H	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	629										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				TGCCAGAGGCGCACCTCCAAC	0.557												
ME3	10873	broad.mit.edu	37	11	86270753	86270753	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:86270753C>T	uc001pbz.2	-	2	550	c.296G>A	c.(295-297)CGG>CAG	p.R99Q	ME3_uc001pca.2_Missense_Mutation_p.R99Q|ME3_uc009yvk.2_Missense_Mutation_p.R99Q|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	99					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	ACTCTGCTGCCGCTCGTAATA	0.537												
GRM5	2915	broad.mit.edu	37	11	88780385	88780385	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:88780385G>A	uc001pcq.2	-	1	856	c.656C>T	c.(655-657)ACA>ATA	p.T219I	GRM5_uc009yvm.2_Missense_Mutation_p.T219I|GRM5_uc009yvn.1_Missense_Mutation_p.T219I	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	219	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CTTACCTTCTGTGTGCACGGC	0.403												
FAT3	120114	broad.mit.edu	37	11	92088438	92088438	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:92088438G>C	uc001pdj.3	+	1	3177	c.3160G>C	c.(3160-3162)GAA>CAA	p.E1054Q		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1054	Cadherin 10.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATCTGTAAAGGAAAACTCACG	0.493										TCGA Ovarian(4;0.039)		
CWC15	51503	broad.mit.edu	37	11	94704653	94704653	+	Splice_Site	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:94704653T>C	uc001pfd.3	-	3	255	c.132_splice	c.e3-1	p.R44_splice	CWC15_uc009ywl.1_Intron|KDM4D_uc001pfe.2_5'Flank	NM_016403	NP_057487	Q9P013	CWC15_HUMAN	CWC15 homolog						nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome	protein binding|RNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTAGTCTGTCTAAAGTAGAAA	0.383												
CCDC82	79780	broad.mit.edu	37	11	96086838	96086838	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:96086838T>C	uc009ywp.2	-	7	1850	c.1607A>G	c.(1606-1608)TAC>TGC	p.Y536C	CCDC82_uc009ywq.2_Missense_Mutation_p.Y536C|CCDC82_uc001pfx.3_Missense_Mutation_p.Y536C|CCDC82_uc009ywr.2_Missense_Mutation_p.Y536C	NM_024725	NP_079001	Q8N4S0	CCD82_HUMAN	coiled-coil domain containing 82	536							protein binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.154)		TTCTTGAAAGTAATCCGCAAA	0.313												
KIAA1377	57562	broad.mit.edu	37	11	101834523	101834523	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:101834523G>A	uc001pgm.2	+	6	3027	c.2757G>A	c.(2755-2757)CCG>CCA	p.P919P	KIAA1377_uc001pgn.2_Silent_p.P875P|KIAA1377_uc010run.1_Silent_p.P720P|KIAA1377_uc009yxa.1_Silent_p.P720P	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	919							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AAAGTTATCCGTCTGTGACTC	0.403												
DYNC2H1	79659	broad.mit.edu	37	11	103058206	103058206	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:103058206G>A	uc001pho.2	+	43	7175	c.7031G>A	c.(7030-7032)CGT>CAT	p.R2344H	DYNC2H1_uc001phn.1_Missense_Mutation_p.R2344H|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2344	AAA 3 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AATACTGGTCGTGTATACAGA	0.408												
CARD16	114769	broad.mit.edu	37	11	104916053	104916053	+	Splice_Site	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:104916053G>T	uc001pip.1	-	1	1	c.-26_splice	c.e1-1		CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CARD16_uc001pio.1_Splice_Site	NM_001017534	NP_001017534	Q5EG05	CAR16_HUMAN	caspase-1 dominant-negative inhibitor pseudo-ICE						regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			skin(1)	1						TTCTTGTGTGGGCTGAAACTG	0.458												
ATM	472	broad.mit.edu	37	11	108098419	108098419	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:108098419G>A	uc001pkb.1	+	2	453	c.68G>A	c.(67-69)CGA>CAA	p.R23Q	ATM_uc009yxr.1_Missense_Mutation_p.R23Q|ATM_uc001pkc.1_Missense_Mutation_p.R23Q	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	23			R -> Q (in a colorectal adenocarcinoma sample; somatic mutation).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R23Q(1)		haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GCTACAGAACGAAAGGTAGTA	0.323			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)		
EXPH5	23086	broad.mit.edu	37	11	108385068	108385068	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:108385068A>C	uc001pkk.2	-	6	1277	c.1166T>G	c.(1165-1167)CTG>CGG	p.L389R	EXPH5_uc010rvy.1_Missense_Mutation_p.L201R|EXPH5_uc010rvz.1_Missense_Mutation_p.L233R|EXPH5_uc010rwa.1_Missense_Mutation_p.L313R	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	389					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGGTGCCCTCAGGAACTCTTC	0.458												
RDX	5962	broad.mit.edu	37	11	110108291	110108291	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:110108291G>A	uc001pku.2	-	11	1487	c.1177C>T	c.(1177-1179)CGT>TGT	p.R393C	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Missense_Mutation_p.R393C|RDX_uc009yxz.2_Missense_Mutation_p.R46C|RDX_uc009yya.2_Intron|RDX_uc001pks.2_5'Flank|RDX_uc001pkt.2_Missense_Mutation_p.R47C|RDX_uc010rwe.1_Missense_Mutation_p.R257C	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	393	Glu-rich.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GCAGCTCGACGCTCCTTTTCA	0.433												
HTR3B	9177	broad.mit.edu	37	11	113803030	113803030	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:113803030C>T	uc001pok.2	+	5	455	c.388C>T	c.(388-390)CCT>TCT	p.P130S	HTR3B_uc001pol.2_Missense_Mutation_p.P119S	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	130	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TGAAAGATACCCTGACCTTCC	0.423												
CADM1	23705	broad.mit.edu	37	11	115088648	115088648	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:115088648G>A	uc001ppi.3	-	6	914	c.785C>T	c.(784-786)GCG>GTG	p.A262V	CADM1_uc001ppf.3_Missense_Mutation_p.A262V|CADM1_uc001ppk.3_Missense_Mutation_p.A262V|CADM1_uc001ppj.3_Missense_Mutation_p.A262V|CADM1_uc001ppl.2_Missense_Mutation_p.A262V|CADM1_uc001pph.3_Missense_Mutation_p.A14V	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	262	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TAACTCAAGCGCGTCCCCTTC	0.458												
DSCAML1	57453	broad.mit.edu	37	11	117335741	117335741	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:117335741T>C	uc001prh.1	-	17	3364	c.3362A>G	c.(3361-3363)CAG>CGG	p.Q1121R		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1061	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACCCCATACTGGGCGAACTT	0.622												
CXCR5	643	broad.mit.edu	37	11	118764511	118764511	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:118764511G>A	uc001pue.3	+	2	368	c.258G>A	c.(256-258)ACG>ACA	p.T86T	CXCR5_uc001puf.2_Silent_p.T41T	NM_001716	NP_001707	P32302	CXCR5_HUMAN	Burkitt lymphoma receptor 1 isoform 1	86	Cytoplasmic (Potential).				B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GCAGTTCCACGGAGACCTTCC	0.657												
HYOU1	10525	broad.mit.edu	37	11	118920545	118920545	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:118920545T>G	uc001puu.2	-	15	1863	c.1670A>C	c.(1669-1671)GAG>GCG	p.E557A	HYOU1_uc001put.2_Missense_Mutation_p.E522A|HYOU1_uc010ryu.1_Missense_Mutation_p.E577A|HYOU1_uc010ryv.1_Missense_Mutation_p.E446A|HYOU1_uc001pux.3_Missense_Mutation_p.E557A|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Missense_Mutation_p.E557A	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	557						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		AAATACAGACTCCACCTGAAA	0.433												
TRIM29	23650	broad.mit.edu	37	11	119993703	119993703	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:119993703G>A	uc001pwz.2	-	5	1518	c.1394C>T	c.(1393-1395)CCG>CTG	p.P465L	TRIM29_uc001pwx.2_5'Flank|TRIM29_uc001pwy.2_5'UTR|TRIM29_uc010rzi.1_Missense_Mutation_p.P204L|TRIM29_uc010rzj.1_Missense_Mutation_p.P198L|TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	465					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		CATGGTGTCCGGTGCACTCCA	0.592												
TRIM29	23650	broad.mit.edu	37	11	120008291	120008291	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:120008291C>T	uc001pwz.2	-	1	573	c.449G>A	c.(448-450)CGG>CAG	p.R150Q	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	150					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GTAGCTGTTCCGCCGGGTCTC	0.642												
ZNF202	7753	broad.mit.edu	37	11	123596771	123596771	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:123596771T>C	uc001pzd.1	-	9	2281	c.1881A>G	c.(1879-1881)GGA>GGG	p.G627G	ZNF202_uc001pzc.1_Silent_p.G403G|ZNF202_uc001pze.1_Silent_p.G627G|ZNF202_uc001pzf.1_Silent_p.G627G	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	627	C2H2-type 8.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		TGAAGCTTTTTCCACAGGTAG	0.517												
OR10G4	390264	broad.mit.edu	37	11	123887208	123887208	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:123887208G>T	uc010sac.1	+	1	927	c.927G>T	c.(925-927)CAG>CAT	p.Q309H		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CACATCCTCAGAGGAAATAAA	0.358												
OR10G7	390265	broad.mit.edu	37	11	123909240	123909240	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:123909240C>A	uc001pzq.1	-	1	469	c.469G>T	c.(469-471)GTC>TTC	p.V157F		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		ATGGTCTGGACAGCAGAGTGC	0.577												
VSIG2	23584	broad.mit.edu	37	11	124619649	124619649	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:124619649G>A	uc001qas.2	-	4	617	c.541C>T	c.(541-543)CGT>TGT	p.R181C	VSIG2_uc001qat.2_Missense_Mutation_p.R181C	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	181	Extracellular (Potential).|Ig-like C2-type.					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		GTTCCAAGACGCACCCAGTTG	0.552												
ARHGAP32	9743	broad.mit.edu	37	11	128840874	128840874	+	Missense_Mutation	SNP	G	G	A	rs112097648		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:128840874G>A	uc009zcp.2	-	22	4192	c.4192C>T	c.(4192-4194)CGC>TGC	p.R1398C	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.R357C|ARHGAP32_uc001qez.2_Missense_Mutation_p.R1049C	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1398	Interaction with GAB2.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GACTCGGCGCGCAGGTGCAGC	0.637												
OPCML	4978	broad.mit.edu	37	11	132307147	132307147	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:132307147G>A	uc001qgs.2	-	4	683	c.633C>T	c.(631-633)CCC>CCT	p.P211P	OPCML_uc001qgu.2_Silent_p.P204P|OPCML_uc010sck.1_Silent_p.P211P|OPCML_uc001qgt.2_Silent_p.P210P|OPCML_uc010scl.1_Silent_p.P170P	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	211	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TCCGCACATCGGGCGCAGCGA	0.537												
IQSEC3	440073	broad.mit.edu	37	12	280307	280307	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:280307C>T	uc001qhw.1	+	10	2191	c.2185C>T	c.(2185-2187)CCG>TCG	p.P729S	IQSEC3_uc001qhu.1_Missense_Mutation_p.P729S	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	1032					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CAGGGAGAGGCCGGCGGAGAG	0.612												
ERC1	23085	broad.mit.edu	37	12	1481092	1481092	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:1481092G>T	uc001qjb.2	+	16	3115	c.2874G>T	c.(2872-2874)GTG>GTT	p.V958V	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Silent_p.V930V|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Silent_p.V958V|ERC1_uc010sdv.1_Silent_p.V666V|ERC1_uc001qje.2_RNA	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	958	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			AAGAGGAAGTGGCTGCCCTGA	0.507												
WNT5B	81029	broad.mit.edu	37	12	1755092	1755092	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:1755092G>A	uc009zdq.2	+	5	996	c.754G>A	c.(754-756)GCG>ACG	p.A252T	WNT5B_uc001qjj.2_Missense_Mutation_p.A252T|WNT5B_uc001qjk.2_Missense_Mutation_p.A252T|WNT5B_uc001qjl.2_Missense_Mutation_p.A252T	NM_032642	NP_116031	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family,	252					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			GTACGACAGCGCGGCCGCCAT	0.692												
TEAD4	7004	broad.mit.edu	37	12	3128323	3128323	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:3128323G>A	uc010sej.1	+	8	844	c.567G>A	c.(565-567)CCG>CCA	p.P189P	TEAD4_uc010sek.1_Silent_p.P146P|TEAD4_uc001qln.2_Silent_p.P61P	NM_003213	NP_003204	Q15561	TEAD4_HUMAN	TEA domain family member 4 isoform 1	190					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			TCCAGCCTCCGCTGCCTCTGC	0.687												
PEX5	5830	broad.mit.edu	37	12	7362774	7362774	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:7362774G>A	uc009zfu.1	+	17	2455	c.1875G>A	c.(1873-1875)GCG>GCA	p.A625A	PEX5_uc001qsw.2_Silent_p.A625A|PEX5_uc010sgc.1_Silent_p.A640A|PEX5_uc001qsu.2_Silent_p.A588A|PEX5_uc010sgd.1_Silent_p.A646A|PEX5_uc001qsv.2_Silent_p.A617A	NM_001131026	NP_001124498	P50542	PEX5_HUMAN	peroxisomal biogenesis factor 5 isoform d	625					protein import into peroxisome matrix, translocation|protein targeting to peroxisome|protein tetramerization|protein transport	cytosol|peroxisomal matrix|peroxisomal membrane	peroxisome matrix targeting signal-1 binding|protein C-terminus binding|protein N-terminus binding			ovary(1)	1						CAGCCGACGCGCGGGATCTGT	0.617												
ACSM4	341392	broad.mit.edu	37	12	7475033	7475033	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:7475033C>T	uc001qsx.1	+	7	1021	c.1021C>T	c.(1021-1023)CGG>TGG	p.R341W		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	341					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						CAAGAGTCTGCGGCACTGCTT	0.512												
CD163	9332	broad.mit.edu	37	12	7649629	7649629	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:7649629G>A	uc001qsz.3	-	5	1007	c.879C>T	c.(877-879)GAC>GAT	p.D293D	CD163_uc001qta.3_Silent_p.D293D|CD163_uc009zfw.2_Silent_p.D293D	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	293	SRCR 3.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TGTCCCAGCCGTCATCACATA	0.507												
KLRG1	10219	broad.mit.edu	37	12	9144878	9144878	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:9144878G>A	uc001qvh.2	+	2	170	c.159G>A	c.(157-159)GTG>GTA	p.V53V	KLRG1_uc001qvg.2_Silent_p.V53V	NM_005810	NP_005801	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G,	53	Helical; Signal-anchor for type II membrane protein; (Potential).				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			central_nervous_system(1)	1						TTCTGAGTGTGCTGCTATACC	0.413												
A2M	2	broad.mit.edu	37	12	9231878	9231878	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:9231878G>T	uc001qvk.1	-	25	3194	c.3081C>A	c.(3079-3081)ACC>ACA	p.T1027T	A2M_uc001qvj.1_Silent_p.T69T|A2M_uc009zgk.1_Silent_p.T877T	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1027					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GCTCCCCAAAGGTGCTGTAGG	0.348												
A2M	2	broad.mit.edu	37	12	9246145	9246145	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:9246145C>T	uc001qvk.1	-	18	2269	c.2156G>A	c.(2155-2157)CGC>CAC	p.R719H	A2M_uc009zgk.1_Missense_Mutation_p.R569H	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	719	Bait region.|Inhibitory.				blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	ATGCACCAGGCGTGCATGGCC	0.443												
PZP	5858	broad.mit.edu	37	12	9318694	9318694	+	Nonsense_Mutation	SNP	G	G	A	rs150067154		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:9318694G>A	uc001qvl.2	-	18	2241	c.2212C>T	c.(2212-2214)CGA>TGA	p.R738*	PZP_uc009zgl.2_Nonsense_Mutation_p.R607*|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Nonsense_Mutation_p.R70*	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AAATAGCTTCGCACCGTTTCA	0.448												
PZP	5858	broad.mit.edu	37	12	9353635	9353635	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:9353635C>A	uc001qvl.2	-	6	552	c.523G>T	c.(523-525)GCA>TCA	p.A175S	PZP_uc009zgl.2_Missense_Mutation_p.A44S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TGCCATTGTGCAATTCGATTT	0.458												
MAGOHB	55110	broad.mit.edu	37	12	10762434	10762434	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:10762434C>T	uc001qyq.1	-	3	312	c.260G>A	c.(259-261)CGA>CAA	p.R87Q	MAGOHB_uc001qyr.1_RNA	NM_018048	NP_060518	Q96A72	MGN2_HUMAN	mago-nashi homolog B	87					mRNA processing|mRNA transport|RNA splicing	nucleus	RNA binding			breast(1)	1						ACAAACCTGTCGGCCAACCCT	0.338												
DUSP16	80824	broad.mit.edu	37	12	12630345	12630345	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:12630345C>T	uc001rao.1	-	7	2052	c.1420G>A	c.(1420-1422)GCC>ACC	p.A474T	DUSP16_uc001ram.1_5'Flank|DUSP16_uc001ran.1_Missense_Mutation_p.A326T	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	474					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		GAAGGCCTGGCGGTCTGCAGC	0.567												
PDE3A	5139	broad.mit.edu	37	12	20806894	20806894	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:20806894C>A	uc001reh.1	+	15	2961	c.2939C>A	c.(2938-2940)GCC>GAC	p.A980D		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	980	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GATGAAGAGGCCAGCCTTGGA	0.453												
ABCC9	10060	broad.mit.edu	37	12	22005053	22005053	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:22005053C>T	uc001rfi.1	-	22	2767	c.2747G>A	c.(2746-2748)CGG>CAG	p.R916Q	ABCC9_uc001rfh.2_Missense_Mutation_p.R916Q|ABCC9_uc001rfj.1_Missense_Mutation_p.R880Q	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	916	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTGATCTTGCCGATTCATAAG	0.353												
SOX5	6660	broad.mit.edu	37	12	23999074	23999074	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:23999074G>T	uc001rfw.2	-	3	426	c.324C>A	c.(322-324)ACC>ACA	p.T108T	SOX5_uc001rfx.2_Silent_p.T95T|SOX5_uc001rfy.2_Silent_p.T95T|SOX5_uc010siv.1_Silent_p.T95T|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Silent_p.T60T|SOX5_uc001rga.2_Silent_p.T73T	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	108					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						TCTGAGGTGAGGTAGATGAGT	0.468												
RASSF8	11228	broad.mit.edu	37	12	26217838	26217838	+	Missense_Mutation	SNP	C	C	T	rs146204306	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:26217838C>T	uc001rgx.2	+	3	732	c.511C>T	c.(511-513)CGT>TGT	p.R171C	RASSF8_uc001rgy.2_Missense_Mutation_p.R171C|RASSF8_uc001rgz.2_Missense_Mutation_p.R171C|RASSF8_uc009zjd.1_Missense_Mutation_p.R171C|RASSF8_uc009zje.1_Missense_Mutation_p.R171C	NM_007211	NP_009142	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family	171					signal transduction						0	Colorectal(261;0.0847)					GAAGCTAATCCGTCTGCAGAC	0.358												
ITPR2	3709	broad.mit.edu	37	12	26752167	26752167	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:26752167G>A	uc001rhg.2	-	30	4330	c.3913C>T	c.(3913-3915)CGC>TGC	p.R1305C		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1305	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCCACGTGGCGGCCATGTGTC	0.423												
KLHDC5	57542	broad.mit.edu	37	12	27950929	27950929	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:27950929G>A	uc001rij.2	+	3	1425	c.1348G>A	c.(1348-1350)GGC>AGC	p.G450S	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	450	Kelch 6.									ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)					CCATAACGACGGCATCTACAT	0.517												
FAR2	55711	broad.mit.edu	37	12	29423430	29423430	+	Silent	SNP	G	G	A	rs149661674		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:29423430G>A	uc001ris.3	+	2	195	c.48G>A	c.(46-48)ACG>ACA	p.T16T	FAR2_uc001rit.2_Silent_p.T16T|FAR2_uc009zjm.2_Intron	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	16					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						TTCTCATCACGGGGGCCACAG	0.507												
DDX11	1663	broad.mit.edu	37	12	31249595	31249595	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:31249595G>A	uc001rjt.1	+	16	1797	c.1546G>A	c.(1546-1548)GGA>AGA	p.G516R	DDX11_uc001rjr.1_Missense_Mutation_p.G516R|DDX11_uc001rjs.1_Missense_Mutation_p.G516R|DDX11_uc001rju.1_Missense_Mutation_p.G194R|DDX11_uc001rjv.1_Missense_Mutation_p.G516R|DDX11_uc001rjw.1_Missense_Mutation_p.G490R|DDX11_uc009zjn.1_RNA	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	516					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					TGAACGGTACGGAGCAGTGTT	0.592										Multiple Myeloma(12;0.14)		
CPNE8	144402	broad.mit.edu	37	12	39223184	39223184	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:39223184A>G	uc001rls.1	-	6	488	c.404T>C	c.(403-405)ATA>ACA	p.I135T		NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	135										pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				TACTTACACTATTGGTTTTTC	0.368												
PRICKLE1	144165	broad.mit.edu	37	12	42859016	42859016	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:42859016C>T	uc010skv.1	-	7	1107	c.820G>A	c.(820-822)GCC>ACC	p.A274T	PRICKLE1_uc001rnl.2_Missense_Mutation_p.A274T|PRICKLE1_uc010skw.1_Missense_Mutation_p.A274T|PRICKLE1_uc001rnm.2_Missense_Mutation_p.A274T	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	274	LIM zinc-binding 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GCTTCCGTGGCGTGCCAGTGC	0.473												
ARID2	196528	broad.mit.edu	37	12	46246296	46246296	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:46246296C>T	uc001ros.1	+	15	4390	c.4390C>T	c.(4390-4392)CGC>TGC	p.R1464C	ARID2_uc001ror.2_Missense_Mutation_p.R1464C|ARID2_uc009zkg.1_Missense_Mutation_p.R920C|ARID2_uc009zkh.1_Missense_Mutation_p.R1091C|ARID2_uc001rou.1_Missense_Mutation_p.R798C	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1464					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GCCTCAGCAACGCCCAAGTGT	0.438												
ZNF641	121274	broad.mit.edu	37	12	48737355	48737355	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:48737355G>C	uc001rrn.1	-	6	883	c.718C>G	c.(718-720)CCC>GCC	p.P240A	ZNF641_uc001rro.1_Missense_Mutation_p.P226A|ZNF641_uc010sls.1_Missense_Mutation_p.P217A	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	240	Transactivation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						AGAAAAGGGGGCCCCAGGAGC	0.517												
RACGAP1	29127	broad.mit.edu	37	12	50386088	50386088	+	Silent	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:50386088G>C	uc001rvt.2	-	16	1828	c.1518C>G	c.(1516-1518)GCC>GCG	p.A506A	RACGAP1_uc009zlm.1_Silent_p.A506A|RACGAP1_uc001rvs.2_Silent_p.A506A|RACGAP1_uc001rvu.2_Silent_p.A506A	NM_013277	NP_037409	Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	506	Rho-GAP.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			kidney(1)	1						GCACAGCATGGGCCACTATTG	0.448												
SLC11A2	4891	broad.mit.edu	37	12	51394196	51394196	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:51394196G>A	uc001rxe.3	-	6	533	c.436C>T	c.(436-438)CGA>TGA	p.R146*	SLC11A2_uc001rxd.3_Translation_Start_Site|SLC11A2_uc001rxc.3_Nonsense_Mutation_p.R146*|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc010smx.1_Nonsense_Mutation_p.R142*|SLC11A2_uc001rxh.1_Nonsense_Mutation_p.R146*|SLC11A2_uc001rxj.1_Nonsense_Mutation_p.R146*|SLC11A2_uc001rxi.2_Nonsense_Mutation_p.R146*|SLC11A2_uc001rxk.1_Nonsense_Mutation_p.R175*|SLC11A2_uc010smy.1_Nonsense_Mutation_p.R109*	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	146	Cytoplasmic (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						AGGATGACTCGTGGGACCTAA	0.418												
KRT85	3891	broad.mit.edu	37	12	52761184	52761184	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:52761184C>T	uc001sag.2	-	1	126	c.6G>A	c.(4-6)TCG>TCA	p.S2S		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	2	Head.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		AGGAGCGGCACGACATCGTGT	0.622												
CALCOCO1	57658	broad.mit.edu	37	12	54107930	54107930	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:54107930G>A	uc001sef.2	-	12	1722	c.1578C>T	c.(1576-1578)GCC>GCT	p.A526A	CALCOCO1_uc001see.2_Silent_p.A27A|CALCOCO1_uc010som.1_Silent_p.A441A|CALCOCO1_uc010son.1_Silent_p.A403A|CALCOCO1_uc001seh.2_Silent_p.A526A|CALCOCO1_uc009znd.2_Silent_p.A526A|CALCOCO1_uc001seg.2_Silent_p.A351A|CALCOCO1_uc010soo.1_Silent_p.A519A	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	526	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						GCCCCACAGCGGCCTCCTCAT	0.562												
HOXC13	3229	broad.mit.edu	37	12	54338837	54338837	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:54338837C>T	uc001sei.2	+	2	905	c.790C>T	c.(790-792)CGC>TGC	p.R264C	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	264	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GCGCAAGAAACGCGTGCCCTA	0.617			T	NUP98	AML							
HOXC12	3228	broad.mit.edu	37	12	54350327	54350327	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:54350327G>A	uc010soq.1	+	2	826	c.826G>A	c.(826-828)GAG>AAG	p.E276K		NM_173860	NP_776272	P31275	HXC12_HUMAN	homeobox C12	276					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						TCTGTTGAGGGAGCAAGCTCT	0.547												
PA2G4	5036	broad.mit.edu	37	12	56504448	56504448	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:56504448C>T	uc001sjm.2	+	9	1233	c.814C>T	c.(814-816)CGT>TGT	p.R272C	PA2G4_uc009zol.2_Missense_Mutation_p.R272C|PA2G4_uc009zom.2_Missense_Mutation_p.R272C	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	272					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			GGTGGAAAGGCGTTTTGATGC	0.443												
SMARCC2	6601	broad.mit.edu	37	12	56563355	56563355	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:56563355G>A	uc001skb.2	-	24	2686	c.2580C>T	c.(2578-2580)ACC>ACT	p.T860T	SMARCC2_uc001skd.2_Silent_p.T891T|SMARCC2_uc001ska.2_Silent_p.T891T|SMARCC2_uc001skc.2_Silent_p.T890T|SMARCC2_uc010sqf.1_Silent_p.T780T	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	860					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			cggcagcagcggtggAGAGGT	0.219												
OBFC2B	79035	broad.mit.edu	37	12	56622977	56622977	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:56622977C>T	uc001ski.2	+	7	740	c.616C>T	c.(616-618)CGG>TGG	p.R206W	OBFC2B_uc001skk.2_Missense_Mutation_p.R231W|OBFC2B_uc001skj.2_Missense_Mutation_p.R222W	NM_024068	NP_076973	Q9BQ15	SOSB1_HUMAN	oligonucleotide/oligosaccharide-binding fold	206					double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	protein binding|single-stranded DNA binding			ovary(1)	1						CAAAGAAACCCGGAGGAGCAG	0.577								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function				
PAN2	9924	broad.mit.edu	37	12	56718087	56718087	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:56718087G>A	uc001skx.2	-	12	2292	c.1919C>T	c.(1918-1920)GCT>GTT	p.A640V	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.A640V|PAN2_uc001sky.2_Missense_Mutation_p.A640V	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	640					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CCTGCCTCCAGCACCTCGATA	0.458												
BAZ2A	11176	broad.mit.edu	37	12	56995134	56995134	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:56995134G>A	uc001slq.1	-	21	4324	c.4130C>T	c.(4129-4131)ACG>ATG	p.T1377M	BAZ2A_uc001slp.1_Missense_Mutation_p.T1375M|BAZ2A_uc001slo.1_Missense_Mutation_p.T205M|BAZ2A_uc009zov.1_Missense_Mutation_p.T347M|BAZ2A_uc009zow.1_Missense_Mutation_p.T1345M	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	1377	Pro-rich.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						AGCCAAGGGCGTGGAAGAGAA	0.517												
LRP1	4035	broad.mit.edu	37	12	57578171	57578171	+	Missense_Mutation	SNP	C	C	T	rs148823753	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:57578171C>T	uc001snd.2	+	38	6588	c.6122C>T	c.(6121-6123)ACG>ATG	p.T2041M		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2041	LDL-receptor class B 19.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTAGATGGCACGGAGCGTGTG	0.592												
SHMT2	6472	broad.mit.edu	37	12	57625344	57625344	+	Splice_Site	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:57625344G>A	uc001snf.1	+	3	321	c.311_splice	c.e3+1	p.R104_splice	SHMT2_uc001sng.1_Splice_Site|SHMT2_uc001snh.1_Intron|SHMT2_uc009zpk.1_Splice_Site_p.R104_splice|SHMT2_uc001sni.1_Splice_Site_p.R83_splice|SHMT2_uc010srg.1_Intron|SHMT2_uc001snj.1_Intron|SHMT2_uc010srh.1_Splice_Site_p.R83_splice|SHMT2_uc001snk.1_Intron|SHMT2_uc010sri.1_Splice_Site_p.R83_splice|SHMT2_uc001snl.2_Splice_Site|SHMT2_uc010srj.1_5'Flank	NM_005412	NP_005403	P34897	GLYM_HUMAN	serine hydroxymethyltransferase 2							microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			ovary(1)|central_nervous_system(1)	2					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CTGGCAAGAGGTGAGGGCTGG	0.597												
ARHGAP9	64333	broad.mit.edu	37	12	57867953	57867953	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:57867953C>T	uc001sod.2	-	19	2253	c.2060G>A	c.(2059-2061)CGG>CAG	p.R687Q	ARHGAP9_uc001sny.2_Intron|ARHGAP9_uc001snz.2_Missense_Mutation_p.R413Q|ARHGAP9_uc001soa.2_Missense_Mutation_p.R286Q|ARHGAP9_uc001sob.2_Missense_Mutation_p.R597Q|ARHGAP9_uc001soc.2_Missense_Mutation_p.R597Q|ARHGAP9_uc001soe.1_Missense_Mutation_p.R676Q	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	616	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			CAAATCTAACCGACCTTCTGG	0.517												
C12orf66	144577	broad.mit.edu	37	12	64609628	64609628	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:64609628G>A	uc001srw.3	-	2	410	c.351C>T	c.(349-351)CAC>CAT	p.H117H	C12orf66_uc009zql.2_Silent_p.H64H	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	117										ovary(1)	1						GTTCTTCCACGTGAGGAGCAG	0.527												
TMBIM4	51643	broad.mit.edu	37	12	66546105	66546105	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:66546105C>T	uc001stc.2	-	3	334	c.258G>A	c.(256-258)GCG>GCA	p.A86A	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Silent_p.A55A|TMBIM4_uc009zqr.2_Silent_p.A133A|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_Silent_p.A86A|TMBIM4_uc009zqs.2_Silent_p.A86A	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	86	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		TTAAAATCAACGCAAAAATCA	0.348												
GRIP1	23426	broad.mit.edu	37	12	66771012	66771012	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:66771012G>A	uc001stk.2	-	20	2760	c.2519C>T	c.(2518-2520)TCT>TTT	p.S840F	GRIP1_uc010sta.1_Missense_Mutation_p.S784F|GRIP1_uc001stj.2_Missense_Mutation_p.S622F|GRIP1_uc001stl.1_Missense_Mutation_p.S732F|GRIP1_uc001stm.2_Missense_Mutation_p.S840F	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	892					androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CAGCGCTTGAGACCAGAAGTT	0.473												
LGR5	8549	broad.mit.edu	37	12	71974201	71974201	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:71974201A>G	uc001swl.2	+	16	1598	c.1550A>G	c.(1549-1551)CAA>CGA	p.Q517R	LGR5_uc001swm.2_Missense_Mutation_p.Q493R|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	517	Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TTTCAGGCTCAAGGTAGGACT	0.368												
NAP1L1	4673	broad.mit.edu	37	12	76461164	76461164	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:76461164C>T	uc001sxw.2	-	4	605	c.193G>A	c.(193-195)GGA>AGA	p.G65R	NAP1L1_uc001sxv.2_Missense_Mutation_p.G23R|NAP1L1_uc001sxz.2_Missense_Mutation_p.G23R|NAP1L1_uc001sxx.2_Missense_Mutation_p.G65R|NAP1L1_uc001sxy.2_Intron|NAP1L1_uc010sty.1_Missense_Mutation_p.G23R|NAP1L1_uc010stz.1_Intron|NAP1L1_uc010sua.1_Missense_Mutation_p.G65R|NAP1L1_uc001syb.2_Missense_Mutation_p.G65R|NAP1L1_uc001sya.2_Missense_Mutation_p.G23R|NAP1L1_uc001syc.2_Missense_Mutation_p.G65R	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	65					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				TCAATGTATCCTGTTGGTGTT	0.363												
E2F7	144455	broad.mit.edu	37	12	77440093	77440093	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:77440093C>T	uc001sym.3	-	5	790	c.554G>A	c.(553-555)CGC>CAC	p.R185H	E2F7_uc001syn.2_Missense_Mutation_p.R185H	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	185	Potential.			R->A: Loss of DNA-binding and inhibition of E2F1-dependent activation.	cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						GTCATAGATGCGTCTCCTTTC	0.488												
LIN7A	8825	broad.mit.edu	37	12	81283062	81283062	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:81283062G>T	uc001szj.1	-	2	362	c.169C>A	c.(169-171)CTT>ATT	p.L57I	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	57	L27.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						TCACTCTGAAGCACTTTTTTG	0.353												
TMTC2	160335	broad.mit.edu	37	12	83324294	83324294	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:83324294G>A	uc001szt.2	+	4	2000	c.1568G>A	c.(1567-1569)CGC>CAC	p.R523H	TMTC2_uc001szr.1_Missense_Mutation_p.R523H|TMTC2_uc001szs.1_Missense_Mutation_p.R523H|TMTC2_uc010suk.1_Missense_Mutation_p.R278H	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	523	TPR 2.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						TTGTACTACCGCAGCAACATG	0.418												
SLC6A15	55117	broad.mit.edu	37	12	85266867	85266867	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:85266867G>A	uc001szv.2	-	7	1601	c.1108C>T	c.(1108-1110)CAA>TAA	p.Q370*	SLC6A15_uc010sul.1_Nonsense_Mutation_p.Q263*|SLC6A15_uc001szw.1_Nonsense_Mutation_p.Q78*	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	370	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						TATTCATACTGTGTAATGCAT	0.264												
LRRIQ1	84125	broad.mit.edu	37	12	85547850	85547850	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:85547850G>A	uc001tac.2	+	23	4809	c.4698G>A	c.(4696-4698)TCG>TCA	p.S1566S		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1566										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AAATGAAATCGAAGAAACTAA	0.264												
KERA	11081	broad.mit.edu	37	12	91449951	91449951	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:91449951A>G	uc001tbl.2	-	2	727	c.108T>C	c.(106-108)ACT>ACC	p.T36T		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	36	LRRNT.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						AGTCATGAATAGTCCAATCAT	0.408												
STAB2	55576	broad.mit.edu	37	12	104030991	104030991	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:104030991G>A	uc001tjw.2	+	7	872	c.686G>A	c.(685-687)CGA>CAA	p.R229Q		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	229	Extracellular (Potential).|EGF-like 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCCAATTACCGAGGCGATGGC	0.408												
TXNRD1	7296	broad.mit.edu	37	12	104733053	104733053	+	Splice_Site	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:104733053T>C	uc010swk.1	+	16	1903	c.1881_splice	c.e16+2	p.E627_splice	TXNRD1_uc010swl.1_Splice_Site_p.E477_splice|TXNRD1_uc010swm.1_Splice_Site_p.E529_splice|TXNRD1_uc010swn.1_Splice_Site_p.E477_splice|TXNRD1_uc010swo.1_Splice_Site_p.E477_splice|TXNRD1_uc010swp.1_Splice_Site_p.E439_splice|TXNRD1_uc010swq.1_Splice_Site_p.E527_splice|TXNRD1_uc001tku.2_Splice_Site|TXNRD1_uc009zun.2_Splice_Site_p.E543_splice	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3						cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						TGTGCAGAGGTGGGTCATCTA	0.463												
USP30	84749	broad.mit.edu	37	12	109509471	109509471	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:109509471C>T	uc010sxi.1	+	5	639	c.535C>T	c.(535-537)CGC>TGC	p.R179C	USP30_uc001tnu.3_Missense_Mutation_p.R148C	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	179	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						TGAGCGAGACCGCCAGCCTCG	0.438												
C12orf34	84915	broad.mit.edu	37	12	110206924	110206924	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:110206924G>A	uc001tpd.1	+	3	1749	c.1190G>A	c.(1189-1191)TGC>TAC	p.C397Y	MGC14436_uc010sxs.1_Intron|MGC14436_uc001tpe.2_Intron|C12orf34_uc001tpf.1_Missense_Mutation_p.C397Y	NM_032829	NP_116218	Q5U5X8	CL034_HUMAN	hypothetical protein LOC84915	397										ovary(1)	1						AAGAGTGTGTGCAACACATCG	0.672												
C12orf51	283450	broad.mit.edu	37	12	112696395	112696395	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:112696395C>T	uc009zwc.2	-	13	1755	c.1737G>A	c.(1735-1737)GCG>GCA	p.A579A	C12orf51_uc010syk.1_Silent_p.A402A|C12orf51_uc001tts.2_Silent_p.A402A|C12orf51_uc001ttt.3_Silent_p.A400A	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TAAGCAGCAACGCCGTCTGAA	0.478												
TBX5	6910	broad.mit.edu	37	12	114793517	114793517	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:114793517G>T	uc001tvo.2	-	9	1872	c.1377C>A	c.(1375-1377)ACC>ACA	p.T459T	TBX5_uc001tvp.2_Silent_p.T459T|TBX5_uc001tvq.2_Silent_p.T409T	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	459				MDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQ TS -> WTGYPTSTSPLTSPRGPWSLGWLAWQPWLPTAGRG NVPSTRPP (in Ref. 1; CAA70592).	cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		GGGCCACGGAGGTCTGGTGCT	0.662												
NOS1	4842	broad.mit.edu	37	12	117672425	117672425	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:117672425C>T	uc001twm.1	-	21	3866	c.3180G>A	c.(3178-3180)CCG>CCA	p.P1060P		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1060	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGTTGACAGGCGGCGCGTCCT	0.627												
NOS1	4842	broad.mit.edu	37	12	117728174	117728174	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:117728174G>A	uc001twm.1	-	4	1596	c.910C>T	c.(910-912)CGC>TGC	p.R304C		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	304					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTGAGGAAGCGTGGACACTTG	0.547												
PRKAB1	5564	broad.mit.edu	37	12	120110208	120110208	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:120110208G>A	uc009zwu.2	+	3	365	c.262G>A	c.(262-264)GGA>AGA	p.G88R	PRKAB1_uc001txg.2_Missense_Mutation_p.G88R	NM_006253	NP_006244	Q9Y478	AAKB1_HUMAN	AMP-activated protein kinase beta 1	88					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol					0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.166)	Adenosine monophosphate(DB00131)|Metformin(DB00331)	GACGGGGGGCGGAAAGGAAGT	0.507												
GCN1L1	10985	broad.mit.edu	37	12	120585995	120585995	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:120585995C>T	uc001txo.2	-	37	4715	c.4702G>A	c.(4702-4704)GTT>ATT	p.V1568I		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1568	HEAT 9.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCCTGATAACGGAGCCGATC	0.602												
PXN	5829	broad.mit.edu	37	12	120651713	120651713	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:120651713G>A	uc001txt.2	-	11	1572	c.1441C>T	c.(1441-1443)CGG>TGG	p.R481W	PXN_uc001txu.2_Missense_Mutation_p.R293W|PXN_uc001txv.2_Missense_Mutation_p.R362W|PXN_uc001txx.2_Missense_Mutation_p.R314W|PXN_uc001txy.2_Missense_Mutation_p.R447W|PXN_uc001txz.2_RNA	NM_001080855	NP_001074324	P49023	PAXI_HUMAN	paxillin isoform 1	481	LIM zinc-binding 3.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			ovary(1)|breast(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGATGGCCCGGGCGCAGCCG	0.617												
OASL	8638	broad.mit.edu	37	12	121458651	121458651	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:121458651A>C	uc001tzj.1	-	6	1264	c.1258T>G	c.(1258-1260)TCC>GCC	p.S420A	OASL_uc001tzk.1_3'UTR	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	420	Ubiquitin-like 1.				interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGAGTGTGGGAGAAGATCCCA	0.562												
KDM2B	84678	broad.mit.edu	37	12	121878950	121878950	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:121878950C>T	uc001uat.2	-	20	3475	c.3371G>A	c.(3370-3372)CGA>CAA	p.R1124Q	KDM2B_uc001uaq.2_Missense_Mutation_p.R564Q|KDM2B_uc010szy.1_Missense_Mutation_p.R564Q|KDM2B_uc001uar.2_Missense_Mutation_p.R715Q|KDM2B_uc001uas.2_Missense_Mutation_p.R1055Q|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.R372Q|KDM2B_uc010szx.1_Missense_Mutation_p.R372Q|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	1124					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						GACGGGCTGTCGCCGGATGAT	0.627												
HIP1R	9026	broad.mit.edu	37	12	123344320	123344320	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:123344320A>G	uc001udj.1	+	24	2467	c.2408A>G	c.(2407-2409)GAC>GGC	p.D803G	HIP1R_uc001udk.1_Missense_Mutation_p.D68G	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	803	I/LWEQ.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		TGGGTGCAGGACATGATGAAC	0.667												
PITPNM2	57605	broad.mit.edu	37	12	123481982	123481982	+	Silent	SNP	G	G	A	rs142848891		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:123481982G>A	uc001uej.1	-	10	1501	c.1362C>T	c.(1360-1362)AAC>AAT	p.N454N	PITPNM2_uc001uek.1_Silent_p.N454N	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	454					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		TGTCGAACACGTTGGCGATGG	0.672												
MPHOSPH9	10198	broad.mit.edu	37	12	123687585	123687585	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:123687585A>C	uc001uel.2	-	6	1018	c.911T>G	c.(910-912)ATT>AGT	p.I304S	MPHOSPH9_uc010tal.1_Intron|MPHOSPH9_uc010tam.1_RNA|MPHOSPH9_uc001uem.2_Intron	NM_022782	NP_073619	Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	304					M phase of mitotic cell cycle	centriole|Golgi membrane					0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		AATCCCTGAAATCTGCTGCTT	0.483												
NCOR2	9612	broad.mit.edu	37	12	124887004	124887004	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:124887004G>T	uc010tba.1	-	14	1703	c.1586C>A	c.(1585-1587)GCG>GAG	p.A529E	NCOR2_uc010tay.1_Missense_Mutation_p.A529E|NCOR2_uc010taz.1_Missense_Mutation_p.A529E|NCOR2_uc010tbb.1_Missense_Mutation_p.A529E|NCOR2_uc010tbc.1_Missense_Mutation_p.A528E|NCOR2_uc001ugj.1_Missense_Mutation_p.A529E	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	529	Potential.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		ctccttctccgcctccttttc	0.333												
TMEM132D	121256	broad.mit.edu	37	12	130184470	130184470	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:130184470G>A	uc009zyl.1	-	2	1181	c.853C>T	c.(853-855)CGT>TGT	p.R285C		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	285	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTGTCCAGACGCAGTTCTCTC	0.527												
EP400	57634	broad.mit.edu	37	12	132504627	132504627	+	Silent	SNP	C	C	T	rs113843264		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:132504627C>T	uc001ujn.2	+	21	4346	c.4311C>T	c.(4309-4311)CCC>CCT	p.P1437P	EP400_uc001ujl.2_Silent_p.P1436P|EP400_uc001ujm.2_Silent_p.P1437P	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1473					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GCCAGAAGCCCGAGGGTCGCA	0.647												
GOLGA3	2802	broad.mit.edu	37	12	133350862	133350862	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:133350862C>T	uc001ukz.1	-	23	4747	c.4188G>A	c.(4186-4188)ACG>ACA	p.T1396T		NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1396	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		TCTTGATGGGCGTGGCAGGGT	0.607												
MPHOSPH8	54737	broad.mit.edu	37	13	20235889	20235889	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:20235889G>A	uc001umh.2	+	8	1852	c.1843G>A	c.(1843-1845)GAC>AAC	p.D615N	MPHOSPH8_uc001umg.2_Missense_Mutation_p.D615N	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	615	ANK 1.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		AGGGCAGGACGACCTCCTGCG	0.512												
ZMYM5	9205	broad.mit.edu	37	13	20426206	20426206	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:20426206C>A	uc010tcn.1	-	3	380	c.115G>T	c.(115-117)GCT>TCT	p.A39S	ZMYM5_uc001umm.1_5'UTR|ZMYM5_uc001umn.2_Missense_Mutation_p.A39S|ZMYM5_uc001umo.2_Missense_Mutation_p.A39S	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	39						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		AAAGGACAAGCTGGATGACCA	0.373												
ZDHHC20	253832	broad.mit.edu	37	13	21976959	21976959	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:21976959C>T	uc001uob.2	-	5	530	c.417G>A	c.(415-417)GCG>GCA	p.A139A	ZDHHC20_uc001uod.2_RNA|ZDHHC20_uc001uoc.2_RNA|ZDHHC20_uc001uoe.2_RNA|ZDHHC20_uc010tcs.1_Silent_p.A76A	NM_153251	NP_694983	Q5W0Z9	ZDH20_HUMAN	zinc finger, DHHC-type containing 20	139	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		all_cancers(29;8.1e-16)|all_epithelial(30;3.63e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000268)|Epithelial(112;0.000735)|OV - Ovarian serous cystadenocarcinoma(117;0.00517)|Lung(94;0.171)		AGCAGTGATGCGCCCGATCAG	0.398												
ATP8A2	51761	broad.mit.edu	37	13	26151257	26151257	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:26151257G>A	uc001uqk.2	+	20	1905	c.1763G>A	c.(1762-1764)CGG>CAG	p.R588Q	ATP8A2_uc010tdi.1_Missense_Mutation_p.R548Q|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.R98Q	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	548	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GGACGACTTCGGCTTTACTGT	0.443												
HSPH1	10808	broad.mit.edu	37	13	31729764	31729764	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:31729764A>T	uc001utj.2	-	3	591	c.193T>A	c.(193-195)TCT>ACT	p.S65T	HSPH1_uc001utk.2_Missense_Mutation_p.S65T|HSPH1_uc010aaw.2_Missense_Mutation_p.S65T|HSPH1_uc001utl.2_Missense_Mutation_p.S67T|HSPH1_uc010tds.1_Missense_Mutation_p.S67T|HSPH1_uc010tdt.1_RNA|HSPH1_uc010aax.1_Missense_Mutation_p.S67T|HSPH1_uc010aay.1_Missense_Mutation_p.S67T	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	65					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TTGAAGTTAGACACCGTATTG	0.333												
N4BP2L2	10443	broad.mit.edu	37	13	33092117	33092117	+	Missense_Mutation	SNP	C	C	T	rs117678407	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:33092117C>T	uc001uuk.3	-	6	1752	c.1574G>A	c.(1573-1575)CGA>CAA	p.R525Q	N4BP2L2_uc001uuj.2_Missense_Mutation_p.R41Q|N4BP2L2_uc010abe.1_Missense_Mutation_p.R96Q|N4BP2L2_uc010tdz.1_Missense_Mutation_p.R81Q	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	525											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		AATCTTCTTTCGAGACACACC	0.343												
PDS5B	23047	broad.mit.edu	37	13	33347331	33347331	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:33347331G>A	uc010abf.2	+	34	4335	c.4177G>A	c.(4177-4179)GTA>ATA	p.V1393I	PDS5B_uc010abg.2_Intron	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1393					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		CTCTAGCCGTGTAGGACGCTC	0.393												
TRPC4	7223	broad.mit.edu	37	13	38266432	38266432	+	Missense_Mutation	SNP	C	C	T	rs147415849		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:38266432C>T	uc001uws.2	-	4	1173	c.938G>A	c.(937-939)CGC>CAC	p.R313H	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.R313H|TRPC4_uc010tey.1_Missense_Mutation_p.R313H|TRPC4_uc010abw.2_Missense_Mutation_p.R140H|TRPC4_uc010abx.2_Missense_Mutation_p.R313H|TRPC4_uc010aby.2_Missense_Mutation_p.R313H	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	313	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ATCGTACCAGCGAGATGCCAG	0.458												
FREM2	341640	broad.mit.edu	37	13	39262147	39262147	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:39262147C>T	uc001uwv.2	+	1	975	c.666C>T	c.(664-666)TCC>TCT	p.S222S		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	222	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCATCCTGTCCGGCTTGGGCG	0.672												
FREM2	341640	broad.mit.edu	37	13	39422774	39422774	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:39422774G>A	uc001uwv.2	+	8	6655	c.6346G>A	c.(6346-6348)GCC>ACC	p.A2116T	FREM2_uc001uww.2_Missense_Mutation_p.A202T	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2116	Extracellular (Potential).			A -> T (in Ref. 3; BAC87040).	cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCCCAGCAAAGCCACAGTGTC	0.408												
KIAA0564	23078	broad.mit.edu	37	13	42277527	42277527	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:42277527G>A	uc001uyj.2	-	27	3207	c.3137C>T	c.(3136-3138)ACG>ATG	p.T1046M		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1046						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		GCCCATGAACGTTTGTTCTGG	0.373												
DGKH	160851	broad.mit.edu	37	13	42742861	42742861	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:42742861G>A	uc001uyl.1	+	11	1295	c.1274G>A	c.(1273-1275)CGA>CAA	p.R425Q	DGKH_uc010tfh.1_Missense_Mutation_p.R425Q|DGKH_uc001uym.1_Missense_Mutation_p.R425Q|DGKH_uc010tfi.1_Missense_Mutation_p.R180Q|DGKH_uc010tfj.1_Missense_Mutation_p.R280Q|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Missense_Mutation_p.R280Q|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	425	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		GACCTTGCCCGAGTTCTTGGC	0.483												
ZC3H13	23091	broad.mit.edu	37	13	46543351	46543351	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:46543351C>T	uc010tfw.1	-	13	3334	c.3328G>A	c.(3328-3330)GCC>ACC	p.A1110T	ZC3H13_uc001vaq.2_5'Flank|ZC3H13_uc001vas.1_Missense_Mutation_p.A1110T|ZC3H13_uc001vat.1_Missense_Mutation_p.A1110T	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1110							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		gtagcagtggcagtagccaca	0.249												
ZC3H13	23091	broad.mit.edu	37	13	46559533	46559533	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:46559533C>T	uc010tfw.1	-	9	1625	c.1619G>A	c.(1618-1620)CGT>CAT	p.R540H	ZC3H13_uc001vas.1_Missense_Mutation_p.R540H|ZC3H13_uc001vat.1_Missense_Mutation_p.R540H	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	540	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TATTTCCGTACGAGAACTTTC	0.458												
ZC3H13	23091	broad.mit.edu	37	13	46616316	46616316	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:46616316A>G	uc010tfw.1	-	3	328	c.322T>C	c.(322-324)TCA>CCA	p.S108P	ZC3H13_uc001vas.1_Missense_Mutation_p.S108P|ZC3H13_uc001vat.1_Missense_Mutation_p.S108P	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	108							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GGTGAGGATGACTCCTCTGTA	0.398												
RCBTB1	55213	broad.mit.edu	37	13	50125518	50125518	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:50125518T>C	uc001vde.1	-	8	1059	c.798A>G	c.(796-798)GGA>GGG	p.G266G		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and	266	RCC1 5.				cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		TATTGCCAGTTCCCAGCTGCC	0.493												
TDRD3	81550	broad.mit.edu	37	13	61102603	61102603	+	Missense_Mutation	SNP	G	G	A	rs140988326	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:61102603G>A	uc001via.2	+	11	1753	c.965G>A	c.(964-966)CGA>CAA	p.R322Q	TDRD3_uc010aef.2_Missense_Mutation_p.R147Q|TDRD3_uc001vhz.3_Missense_Mutation_p.R322Q|TDRD3_uc010aeg.2_Missense_Mutation_p.R415Q|TDRD3_uc001vib.3_Missense_Mutation_p.R321Q	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	322					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		CATCCTCCTCGAAATGATACC	0.398												
C13orf34	79866	broad.mit.edu	37	13	73320743	73320743	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:73320743C>T	uc001viv.1	+	10	1095	c.976C>T	c.(976-978)CCA>TCA	p.P326S	C13orf34_uc010thq.1_Missense_Mutation_p.P101S|C13orf34_uc010aen.1_Missense_Mutation_p.P401S|C13orf34_uc010thr.1_Missense_Mutation_p.P256S|C13orf34_uc001viw.1_Missense_Mutation_p.P275S	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	326					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		TGGCTGCTCGCCAATTAAAAA	0.398												
GPR180	160897	broad.mit.edu	37	13	95279412	95279412	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:95279412G>A	uc001vly.2	+	9	1388	c.1310G>A	c.(1309-1311)CGC>CAC	p.R437H	GPR180_uc001vlz.2_Missense_Mutation_p.R336H|GPR180_uc010afi.2_Missense_Mutation_p.R198H	NM_180989	NP_851320	Q86V85	GP180_HUMAN	G protein-coupled receptor 180 precursor	437						integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					CACAAAAGTCGCCCTCATTTC	0.358												
HS6ST3	266722	broad.mit.edu	37	13	96743551	96743551	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:96743551C>T	uc001vmw.2	+	1	459	c.435C>T	c.(433-435)CGC>CGT	p.R145R		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	145	Lumenal (Potential).					integral to membrane	sulfotransferase activity	p.R145C(1)		ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					TCAAAGGGCGCGACGTGATCG	0.612												
FARP1	10160	broad.mit.edu	37	13	99092253	99092253	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:99092253C>A	uc001vnj.2	+	22	2808	c.2472C>A	c.(2470-2472)TGC>TGA	p.C824*	FARP1_uc001vnh.2_Nonsense_Mutation_p.C855*	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	824	PH 1.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TGCCCCACTGCCTGACCCTCC	0.612												
NALCN	259232	broad.mit.edu	37	13	101710303	101710303	+	Missense_Mutation	SNP	G	G	A	rs143587652		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:101710303G>A	uc001vox.1	-	43	5200	c.5011C>T	c.(5011-5013)CGT>TGT	p.R1671C		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1671	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GAGGGCAGACGCCACTGCCCA	0.542												
MYO16	23026	broad.mit.edu	37	13	109459100	109459100	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:109459100T>C	uc001vqt.1	+	7	875	c.749T>C	c.(748-750)ATA>ACA	p.I250T	MYO16_uc010agk.1_Missense_Mutation_p.I272T|MYO16_uc001vqu.1_Missense_Mutation_p.I50T	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	250	ANK 6.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GACCTCAACATAGTAGATGAT	0.418												
SOX1	6656	broad.mit.edu	37	13	112722004	112722004	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:112722004A>G	uc001vsb.1	+	1	92	c.32A>G	c.(31-33)CAC>CGC	p.H11R		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	11					chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		ACCGACCTGCACTCGCCCGGC	0.572												
TMCO3	55002	broad.mit.edu	37	13	114174950	114174950	+	Silent	SNP	C	C	T	rs150929637		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:114174950C>T	uc001vtu.3	+	8	1606	c.1245C>T	c.(1243-1245)ACC>ACT	p.T415T	TMCO3_uc001vtt.3_Silent_p.T415T	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	415						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			ACTACAGCACCGTGCTCCTCG	0.537												
TEP1	7011	broad.mit.edu	37	14	20854765	20854765	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:20854765A>C	uc001vxe.2	-	19	2742	c.2702T>G	c.(2701-2703)CTT>CGT	p.L901R	TEP1_uc010ahk.2_Missense_Mutation_p.L251R|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.L793R	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	901					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TGAAATGAAAAGCCGGATGCT	0.592												
OSGEP	55644	broad.mit.edu	37	14	20916315	20916315	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:20916315T>C	uc001vxf.2	-	7	1008	c.652A>G	c.(652-654)ATG>GTG	p.M218V		NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	218					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		GTGGCCAGCATCCGATGGGCT	0.433												
EDDM3B	64184	broad.mit.edu	37	14	21238745	21238745	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:21238745G>A	uc001vyd.2	+	2	534	c.436G>A	c.(436-438)GGC>AGC	p.G146S		NM_022360	NP_071755	P56851	EP3B_HUMAN	human epididymis-specific 3 beta precursor	146					spermatid development	extracellular region				ovary(1)	1						AGAACCTATCGGCAACTAGAA	0.453												
RAB2B	84932	broad.mit.edu	37	14	21936840	21936840	+	Silent	SNP	G	G	A	rs150391208	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:21936840G>A	uc010tlt.1	-	4	359	c.258C>T	c.(256-258)TAC>TAT	p.Y86Y	RAB2B_uc010tls.1_Silent_p.Y40Y|RAB2B_uc001wax.2_Silent_p.Y21Y|RAB2B_uc010ain.2_Intron	NM_032846	NP_116235	Q8WUD1	RAB2B_HUMAN	RAB2B protein isoform 1	86					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			ovary(1)	1	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		TTGTAATGTCGTACACCAGCA	0.458												
HOMEZ	57594	broad.mit.edu	37	14	23745054	23745054	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:23745054C>T	uc001wja.2	-	2	1531	c.1383G>A	c.(1381-1383)CCG>CCA	p.P461P	HOMEZ_uc001wjb.2_Silent_p.P463P	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	homeodomain leucine zipper protein	461	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GTTGTATATCCGGTGGGGGTG	0.557												
MYH7	4625	broad.mit.edu	37	14	23887443	23887443	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:23887443C>T	uc001wjx.2	-	30	4251	c.4145G>A	c.(4144-4146)CGG>CAG	p.R1382Q	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1382	Potential.		R -> W (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CTCCTCAGTCCGCTGAATGGC	0.637												
LRRC16B	90668	broad.mit.edu	37	14	24525864	24525864	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:24525864T>C	uc001wlj.2	+	12	1056	c.899T>C	c.(898-900)TTC>TCC	p.F300S		NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	300										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		CTCCTCTGCTTCCCCTCTGGC	0.622												
TGM1	7051	broad.mit.edu	37	14	24729876	24729876	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:24729876C>T	uc001wod.2	-	4	661	c.537G>A	c.(535-537)ACG>ACA	p.T179T	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	179					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGATCACGTGCGTGCCCTTGC	0.612												
LTB4R2	56413	broad.mit.edu	37	14	24780931	24780931	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:24780931C>T	uc001woq.1	+	1	2771	c.1154C>T	c.(1153-1155)CCG>CTG	p.P385L	CIDEB_uc001woo.2_5'Flank|CIDEB_uc001wop.2_5'Flank|LTB4R2_uc001wor.2_Missense_Mutation_p.P354L|LTB4R_uc001wos.2_5'UTR|LTB4R_uc010alp.2_5'Flank|LTB4R_uc001wou.2_5'Flank	NM_019839	NP_062813	Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	385	Cytoplasmic (Potential).				chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane					0				GBM - Glioblastoma multiforme(265;0.018)		AAGGACGGTCCGGAATGGGAC	0.627												
NYNRIN	57523	broad.mit.edu	37	14	24880323	24880323	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:24880323T>C	uc001wpf.3	+	5	2774	c.2456T>C	c.(2455-2457)ATG>ACG	p.M819T		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	819					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GGAATTGCCATGGCAGTGCAG	0.597											OREG0022626	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
NYNRIN	57523	broad.mit.edu	37	14	24884436	24884436	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:24884436C>T	uc001wpf.3	+	9	3799	c.3481C>T	c.(3481-3483)CGC>TGC	p.R1161C		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1161					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GCTGCCCTTCCGCCTGGAGGT	0.647												
STRN3	29966	broad.mit.edu	37	14	31424869	31424869	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:31424869C>T	uc001wqu.2	-	3	633	c.417G>A	c.(415-417)ACG>ACA	p.T139T	STRN3_uc001wqv.2_Silent_p.T139T|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	139					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		GGTTCAGTTCCGTGCCATATT	0.299												
HECTD1	25831	broad.mit.edu	37	14	31575978	31575978	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:31575978G>A	uc001wrc.1	-	38	7589	c.7100C>T	c.(7099-7101)GCT>GTT	p.A2367V	HECTD1_uc001wra.1_Missense_Mutation_p.A493V|HECTD1_uc001wrb.1_Missense_Mutation_p.A493V	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2367	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CCTCTTGATAGCAAGGTCTTT	0.388												
AKAP6	9472	broad.mit.edu	37	14	33292305	33292305	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:33292305C>A	uc001wrq.2	+	13	5456	c.5286C>A	c.(5284-5286)ACC>ACA	p.T1762T		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1762					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTACCCTTACCTTGACTGAAG	0.453												
EAPP	55837	broad.mit.edu	37	14	34985626	34985626	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:34985626C>T	uc001wsd.1	-	6	857	c.748G>A	c.(748-750)GTG>ATG	p.V250M		NM_018453	NP_060923	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	250					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		ATTTCTTCCACATCTGTCTCT	0.443												
NKX2-1	7080	broad.mit.edu	37	14	36987203	36987203	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:36987203C>T	uc001wtt.2	-	2	737	c.396G>A	c.(394-396)GCG>GCA	p.A132A	SFTA3_uc001wts.2_Intron|NKX2-1_uc001wtu.2_Silent_p.A162A|NKX2-1_uc001wtv.2_Silent_p.A132A|uc001wtw.1_5'Flank	NM_003317	NP_003308	P43699	NKX21_HUMAN	thyroid transcription factor 1 isoform 2	132					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			skin(1)	1	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		TCATGCCGCTCGCCGGGCCCA	0.716			A		NSCLC							
FSCB	84075	broad.mit.edu	37	14	44974717	44974717	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:44974717G>A	uc001wvn.2	-	1	1783	c.1474C>T	c.(1474-1476)CGG>TGG	p.R492W		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	492	Ala-rich.					cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGTGGAGACCGAGCTTCGGCA	0.507												
FAM179B	23116	broad.mit.edu	37	14	45478141	45478141	+	Missense_Mutation	SNP	G	G	A	rs145931350		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:45478141G>A	uc001wvv.2	+	6	3139	c.2930G>A	c.(2929-2931)CGT>CAT	p.R977H	FAM179B_uc001wvw.2_Missense_Mutation_p.R977H|FAM179B_uc010anc.2_Intron	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	977	Ser-rich.						binding			skin(2)|upper_aerodigestive_tract(1)	3						AGGTCCCTTCGTAATAGTGCA	0.358												
TMX1	81542	broad.mit.edu	37	14	51710663	51710663	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:51710663C>T	uc001wza.3	+	2	367	c.242C>T	c.(241-243)GCG>GTG	p.A81V	TMX1_uc010tqr.1_Missense_Mutation_p.A81V|TMX1_uc010aoa.2_5'UTR	NM_030755	NP_110382	Q9H3N1	TMX1_HUMAN	thioredoxin domain containing 1 precursor	81	Thioredoxin.|Extracellular (Potential).				anti-apoptosis|cell proliferation|cell redox homeostasis|DNA replication|electron transport chain|ER to Golgi vesicle-mediated transport|leukocyte activation|positive regulation of growth|positive regulation of transcription, DNA-dependent|response to stress|signal transduction	endoplasmic reticulum membrane|integral to membrane|membrane fraction	arsenate reductase (thioredoxin) activity|disulfide oxidoreductase activity				0						GTTAATATTGCGAAAGTAGAT	0.398												
KIAA0831	22863	broad.mit.edu	37	14	55836420	55836420	+	Missense_Mutation	SNP	C	C	T	rs144919020		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:55836420C>T	uc001xbx.1	-	10	1432	c.1396G>A	c.(1396-1398)GCG>ACG	p.A466T	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbw.1_Missense_Mutation_p.A353T	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	466					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						CTGCTGCTCGCGATGGGTGGG	0.567												
SYT16	83851	broad.mit.edu	37	14	62547711	62547711	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:62547711G>A	uc001xfu.1	+	4	1350	c.1153G>A	c.(1153-1155)GTC>ATC	p.V385I	SYT16_uc010tsd.1_3'UTR|SYT16_uc010tse.1_5'UTR	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	385	C2 1.									central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		CCGAAGTGGTGTCAACTCCTG	0.542												
SYNE2	23224	broad.mit.edu	37	14	64634309	64634309	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:64634309T>C	uc001xgm.2	+	92	17087	c.16857T>C	c.(16855-16857)GAT>GAC	p.D5619D	SYNE2_uc001xgl.2_Silent_p.D5619D|SYNE2_uc010apy.2_Silent_p.D2004D|SYNE2_uc001xgn.2_Silent_p.D581D|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_5'UTR|SYNE2_uc001xgq.2_5'UTR	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5619	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCAAAGTGGATGTGGCTAACA	0.458												
PLEK2	26499	broad.mit.edu	37	14	67862133	67862133	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:67862133C>T	uc001xjh.1	-	3	427	c.375G>A	c.(373-375)CCG>CCA	p.P125P		NM_016445	NP_057529	Q9NYT0	PLEK2_HUMAN	pleckstrin 2	125					actin cytoskeleton organization|intracellular signal transduction	cytoplasm|cytoskeleton|lamellipodium membrane				ovary(1)|pancreas(1)	2				all cancers(60;0.000728)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.00953)		GGCTGATGTGCGGGGGCAGCT	0.662												
PCNX	22990	broad.mit.edu	37	14	71542931	71542931	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:71542931C>T	uc001xmo.2	+	28	5578	c.5132C>T	c.(5131-5133)TCG>TTG	p.S1711L	PCNX_uc010are.1_Missense_Mutation_p.S1600L|PCNX_uc010arf.1_Missense_Mutation_p.S499L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1711						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GTTACGACCTCGTCTAAGCTA	0.368												
SIPA1L1	26037	broad.mit.edu	37	14	72205804	72205804	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:72205804G>T	uc001xms.2	+	22	5689	c.5341G>T	c.(5341-5343)GAG>TAG	p.E1781*	SIPA1L1_uc001xmt.2_Nonsense_Mutation_p.E1760*|SIPA1L1_uc001xmu.2_Nonsense_Mutation_p.E1759*|SIPA1L1_uc001xmv.2_Nonsense_Mutation_p.E1780*|SIPA1L1_uc010ttm.1_Nonsense_Mutation_p.E1234*|SIPA1L1_uc001xmw.2_Nonsense_Mutation_p.E546*	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1781	Potential.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAGGCTACAGGAGGAGTCCCA	0.532												
FAM161B	145483	broad.mit.edu	37	14	74413287	74413287	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:74413287C>T	uc001xpd.1	-	2	182	c.76G>A	c.(76-78)GCA>ACA	p.A26T		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						TCTGTGTCTGCGAAGGACTCG	0.463												
YLPM1	56252	broad.mit.edu	37	14	75296006	75296006	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:75296006A>G	uc001xqj.3	+	19	6378	c.6254A>G	c.(6253-6255)GAT>GGT	p.D2085G	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1890					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CAGCTCCCCGATGATTATGAT	0.473												
DLST	1743	broad.mit.edu	37	14	75367834	75367834	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:75367834C>T	uc001xqv.2	+	14	1188	c.1125C>T	c.(1123-1125)GGC>GGT	p.G375G	DLST_uc001xqu.2_Silent_p.G287G|DLST_uc001xqt.2_Silent_p.G291G|DLST_uc010tuw.1_Silent_p.G289G	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	375					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		GCAATGGAGGCGTTTTTGGCT	0.473												
TTLL5	23093	broad.mit.edu	37	14	76368503	76368503	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:76368503G>A	uc001xrx.2	+	31	3964	c.3759G>A	c.(3757-3759)GGG>GGA	p.G1253G	TTLL5_uc001xsa.2_Silent_p.G327G	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1253					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		CCGCGGAAGGGCAGCTGAATG	0.567												
ESRRB	2103	broad.mit.edu	37	14	76928920	76928920	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:76928920G>A	uc001xsq.1	+	3	497	c.430G>A	c.(430-432)GAG>AAG	p.E144K	ESRRB_uc001xsr.2_Missense_Mutation_p.E144K|ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	144						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		GGCCACCAACGAGTGCGAGAT	0.637												
ISM2	145501	broad.mit.edu	37	14	77942189	77942189	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:77942189C>T	uc001xtz.2	-	7	1539	c.1465G>A	c.(1465-1467)GCC>ACC	p.A489T	ISM2_uc001xua.2_3'UTR|ISM2_uc001xty.2_Missense_Mutation_p.A401T|ISM2_uc010tvl.1_Missense_Mutation_p.A408T	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	489	AMOP.					extracellular region				skin(1)	1						CAGTGCTGGGCGGCCAGTGTG	0.662												
KCNK10	54207	broad.mit.edu	37	14	88729810	88729810	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:88729810C>T	uc001xwo.2	-	2	580	c.123G>A	c.(121-123)CCG>CCA	p.P41P	KCNK10_uc001xwm.2_Silent_p.P46P|KCNK10_uc001xwn.2_Silent_p.P46P	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	41	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						TGGACAGGCGCGGAGTTGGAG	0.652												
TTC7B	145567	broad.mit.edu	37	14	91247111	91247111	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:91247111C>T	uc001xyp.2	-	3	538	c.416G>A	c.(415-417)CGG>CAG	p.R139Q		NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	139							binding			ovary(2)	2		Melanoma(154;0.222)				TGCGATCACCCGCAGCCTGTA	0.567												
KIAA1409	57578	broad.mit.edu	37	14	94087971	94087971	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:94087971A>G	uc001ybv.1	+	28	4010	c.3927A>G	c.(3925-3927)GAA>GAG	p.E1309E	KIAA1409_uc001ybs.1_Silent_p.E1287E	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1464						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GATCAGGTGAAATAGAACTGG	0.393												
PPP4R4	57718	broad.mit.edu	37	14	94674876	94674876	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:94674876G>A	uc001ycs.1	+	3	421	c.267G>A	c.(265-267)ACG>ACA	p.T89T	PPP4R4_uc001ycr.2_Silent_p.T89T	NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	89						cytoplasm|protein serine/threonine phosphatase complex	protein binding	p.T89M(1)		skin(3)|upper_aerodigestive_tract(1)	4						CCACTGAGACGCTTCGGAGAG	0.388												
SERPINA12	145264	broad.mit.edu	37	14	94964713	94964713	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:94964713C>T	uc001ydj.2	-	3	818	c.22G>A	c.(22-24)GCC>ACC	p.A8T		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	8					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		AGAAAAATGGCCAGGCCTAGT	0.453												
SERPINA5	5104	broad.mit.edu	37	14	95053815	95053815	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:95053815C>T	uc001ydm.2	+	3	326	c.116C>T	c.(115-117)ACG>ATG	p.T39M	SERPINA5_uc010ave.2_Missense_Mutation_p.T39M|SERPINA5_uc001ydn.1_Missense_Mutation_p.T39M	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	39					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	GTAGGTGCCACGGTGGCCCCC	0.622												
KIAA0284	283638	broad.mit.edu	37	14	105346747	105346747	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:105346747C>T	uc010axb.2	+	6	681	c.457C>T	c.(457-459)CGG>TGG	p.R153W	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.R83W|KIAA0284_uc001yps.2_Missense_Mutation_p.R59W	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	153						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GAAGGGGGACCGGAGACCAGG	0.667												
AHNAK2	113146	broad.mit.edu	37	14	105406444	105406444	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:105406444T>C	uc010axc.1	-	7	15464	c.15344A>G	c.(15343-15345)CAG>CGG	p.Q5115R	AHNAK2_uc001ypx.2_Missense_Mutation_p.Q5015R	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5115						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			AGCTTCAGGCTGGCTCACCTC	0.582												
RYR3	6263	broad.mit.edu	37	15	34113561	34113561	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:34113561G>A	uc001zhi.2	+	79	10976	c.10906G>A	c.(10906-10908)GCT>ACT	p.A3636T	RYR3_uc010bar.2_Missense_Mutation_p.A3631T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3636					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GATGATAAGCGCTAGCAAAGG	0.473												
RYR3	6263	broad.mit.edu	37	15	34145278	34145278	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:34145278T>C	uc001zhi.2	+	95	13731	c.13661T>C	c.(13660-13662)GTA>GCA	p.V4554A	RYR3_uc010bar.2_Missense_Mutation_p.V4549A	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4554					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GACAAGTTTGTAAAGAGAAAG	0.353												
C15orf55	256646	broad.mit.edu	37	15	34649679	34649679	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:34649679G>A	uc001zif.2	+	7	3541	c.3386G>A	c.(3385-3387)CGT>CAT	p.R1129H	C15orf55_uc010ucc.1_Missense_Mutation_p.R1157H|C15orf55_uc010ucd.1_Missense_Mutation_p.R1147H	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	1129						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		AAGAAACGACGTCGTAGCCAG	0.587			T	BRD3|BRD4	lethal midline carcinoma							
LPCAT4	254531	broad.mit.edu	37	15	34655878	34655878	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:34655878C>T	uc001zig.2	-	6	789	c.695G>A	c.(694-696)CGC>CAC	p.R232H		NM_153613	NP_705841	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	232					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding				0						GTTGGGGTAGCGGATGAGGAC	0.512												
INO80	54617	broad.mit.edu	37	15	41366688	41366688	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:41366688G>A	uc001zni.2	-	10	1420	c.1207C>T	c.(1207-1209)CGA>TGA	p.R403*	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	403	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.|DBINO.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						CCCATATCTCGTTTGCGACTC	0.423												
LTK	4058	broad.mit.edu	37	15	41800405	41800405	+	Nonsense_Mutation	SNP	C	C	A	rs141049740		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:41800405C>A	uc001zoa.3	-	9	1289	c.1111G>T	c.(1111-1113)GGA>TGA	p.G371*	LTK_uc001zob.3_Nonsense_Mutation_p.G310*|LTK_uc010ucx.1_Nonsense_Mutation_p.G310*|LTK_uc010bcg.2_Nonsense_Mutation_p.G53*	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	371	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		TCTACCTCTCCGTGGTTCTCG	0.458										TSP Lung(18;0.14)		
LTK	4058	broad.mit.edu	37	15	41804949	41804949	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:41804949C>T	uc001zoa.3	-	3	493	c.315G>A	c.(313-315)CTG>CTA	p.L105L	LTK_uc001zob.3_Silent_p.L105L|LTK_uc010ucx.1_Silent_p.L105L|LTK_uc010bcg.2_Intron	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	105	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GCACGCCTCTCAGCTGCCCGG	0.697										TSP Lung(18;0.14)		
MAPKBP1	23005	broad.mit.edu	37	15	42105236	42105236	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:42105236G>A	uc001zok.3	+	8	1042	c.756G>A	c.(754-756)ACG>ACA	p.T252T	MAPKBP1_uc001zoj.3_Silent_p.T252T|MAPKBP1_uc010bcj.2_5'UTR|MAPKBP1_uc010bci.2_Silent_p.T252T|MAPKBP1_uc010udb.1_Silent_p.T140T|MAPKBP1_uc010bck.2_5'UTR|MAPKBP1_uc010bcl.2_5'UTR	NM_001128608	NP_001122080	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein	252										central_nervous_system(5)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	10		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TCTGCATCACGTCCTCAGGGC	0.577												
CDAN1	146059	broad.mit.edu	37	15	43021275	43021275	+	Missense_Mutation	SNP	C	C	A	rs145082607		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:43021275C>A	uc001zql.2	-	19	2708	c.2591G>T	c.(2590-2592)CGG>CTG	p.R864L	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.R190L	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	864						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CTCTACGGTCCGGCGCAAGGA	0.562												
LCMT2	9836	broad.mit.edu	37	15	43622232	43622232	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:43622232G>T	uc001zrg.2	-	1	660	c.456C>A	c.(454-456)AGC>AGA	p.S152R	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	152					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	AGTAGTCTGCGCTCTCAAAGC	0.677												
CKMT1B	1159	broad.mit.edu	37	15	43891410	43891410	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:43891410G>A	uc001zsc.2	+	10	1585	c.1193G>A	c.(1192-1194)CGG>CAG	p.R398Q	CKMT1B_uc010uds.1_Missense_Mutation_p.R429Q|CKMT1B_uc001zsd.3_Missense_Mutation_p.R398Q|CKMT1B_uc010bdj.2_RNA	NM_020990	NP_066270	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B precursor	398	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	GATTGTGAACGGCGTCTGGAG	0.493												
WDR76	79968	broad.mit.edu	37	15	44131849	44131849	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:44131849C>T	uc001zti.1	+	5	678	c.655C>T	c.(655-657)CGA>TGA	p.R219*		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	219											0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		AAGGTCAATGCGATTACTAAA	0.373												
USP8	9101	broad.mit.edu	37	15	50774185	50774185	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:50774185C>A	uc001zym.3	+	12	2226	c.1726C>A	c.(1726-1728)CCA>ACA	p.P576T	USP8_uc001zyk.1_Missense_Mutation_p.P277T|USP8_uc001zyl.3_Missense_Mutation_p.P576T|USP8_uc001zyn.3_Missense_Mutation_p.P576T|USP8_uc010ufh.1_Missense_Mutation_p.P499T|USP8_uc010bev.1_Missense_Mutation_p.P205T	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	576					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GAAAAGGTGTCCAACCCCAGA	0.343												
TRPM7	54822	broad.mit.edu	37	15	50901830	50901830	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:50901830C>T	uc001zyt.3	-	19	2792	c.2528G>A	c.(2527-2529)CGA>CAA	p.R843Q	TRPM7_uc010bew.1_Missense_Mutation_p.R843Q|TRPM7_uc001zyu.2_Missense_Mutation_p.R401Q	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	843	Extracellular (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		ATAAAACTTTCGCGTAATTGG	0.299												
GLDN	342035	broad.mit.edu	37	15	51634199	51634199	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:51634199C>T	uc002aba.2	+	1	487	c.318C>T	c.(316-318)GCC>GCT	p.A106A	GLDN_uc010bez.1_Silent_p.A106A	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	106	Extracellular (Potential).				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		ATATCCGCGCCGAGAGCCATG	0.726												
UNC13C	440279	broad.mit.edu	37	15	54793039	54793039	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:54793039C>T	uc002ack.2	+	20	5164	c.5164C>T	c.(5164-5166)CAG>TAG	p.Q1722*		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1722	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ACAGTTCCAGCAGACATCTGA	0.448												
PIGB	9488	broad.mit.edu	37	15	55626105	55626105	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:55626105C>T	uc002act.2	+	6	1010	c.694C>T	c.(694-696)CGT>TGT	p.R232C	PIGB_uc010ugg.1_Missense_Mutation_p.R37C	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	232	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		CTTCATAATTCGTCCCACAGC	0.383												
CGNL1	84952	broad.mit.edu	37	15	57810601	57810601	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:57810601G>A	uc002aeg.2	+	10	2697	c.2621G>A	c.(2620-2622)CGA>CAA	p.R874Q	CGNL1_uc010bfw.2_Missense_Mutation_p.R874Q	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	874	Potential.					myosin complex|tight junction	motor activity	p.R874R(1)		skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		GGAGAAATACGACAGTTAGAG	0.478												
VPS13C	54832	broad.mit.edu	37	15	62148607	62148607	+	Nonsense_Mutation	SNP	G	G	A	rs138846118		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:62148607G>A	uc002agz.2	-	83	11028	c.10954C>T	c.(10954-10956)CGA>TGA	p.R3652*	VPS13C_uc002aha.2_Nonsense_Mutation_p.R3609*	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3652					protein localization					ovary(2)	2						CACAACACTCGCCTATTTTGC	0.378												
TLN2	83660	broad.mit.edu	37	15	63054564	63054564	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:63054564A>G	uc002alb.3	+	36	4873	c.4873A>G	c.(4873-4875)AAC>GAC	p.N1625D	TLN2_uc002alc.3_Missense_Mutation_p.N18D|TLN2_uc002ald.2_Missense_Mutation_p.N18D	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1625					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TCTGGCCATCAACCCCAAAGA	0.542												
ZNF609	23060	broad.mit.edu	37	15	64966762	64966762	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:64966762G>A	uc002ann.2	+	4	1709	c.1709G>A	c.(1708-1710)CGA>CAA	p.R570Q		NM_015042	NP_055857	O15014	ZN609_HUMAN	zinc finger protein 609	570						nucleus	zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCCAAAGTTCGACTTGTAGAG	0.527												
ITGA11	22801	broad.mit.edu	37	15	68623337	68623337	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:68623337C>A	uc002ari.2	-	15	1970	c.1883G>T	c.(1882-1884)GGC>GTC	p.G628V	ITGA11_uc010bib.2_Missense_Mutation_p.G628V	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	628	FG-GAP 7.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	CACAGCGTTGCCAAGGGCTCC	0.557												
MYO9A	4649	broad.mit.edu	37	15	72170488	72170488	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:72170488G>A	uc002atl.3	-	31	6297	c.5824C>T	c.(5824-5826)CGT>TGT	p.R1942C	MYO9A_uc002atk.2_Missense_Mutation_p.R737C|MYO9A_uc002atm.1_Missense_Mutation_p.R738C	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	1942	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						AGTGAATCACGCTGCTCAAGC	0.383												
PKM2	5315	broad.mit.edu	37	15	72502148	72502148	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:72502148A>G	uc002atx.1	-	5	672	c.431T>C	c.(430-432)CTG>CCG	p.L144P	PKM2_uc002ats.1_5'Flank|PKM2_uc002att.1_5'Flank|PKM2_uc002atu.1_5'UTR|PKM2_uc010bit.1_Missense_Mutation_p.L149P|PKM2_uc010uki.1_Missense_Mutation_p.L218P|PKM2_uc002atv.1_Missense_Mutation_p.L179P|PKM2_uc002atw.1_Missense_Mutation_p.L144P|PKM2_uc002aty.1_Missense_Mutation_p.L144P|PKM2_uc010ukj.1_Missense_Mutation_p.L129P|PKM2_uc010ukk.1_Missense_Mutation_p.L70P|PKM2_uc010biu.1_Missense_Mutation_p.L165P|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	144					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	GGCGTTATCCAGCGTGATTTT	0.517												
PML	5371	broad.mit.edu	37	15	74315711	74315711	+	Missense_Mutation	SNP	G	G	A	rs149871195		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:74315711G>A	uc002awv.2	+	3	1285	c.1145G>A	c.(1144-1146)CGC>CAC	p.R382H	PML_uc002awm.2_Missense_Mutation_p.R382H|PML_uc002awl.2_Missense_Mutation_p.R382H|PML_uc002awj.1_Missense_Mutation_p.R382H|PML_uc002awk.2_Missense_Mutation_p.R382H|PML_uc002awn.2_Missense_Mutation_p.R382H|PML_uc002awo.2_Missense_Mutation_p.R382H|PML_uc002awp.2_Missense_Mutation_p.R382H|PML_uc002awq.2_Missense_Mutation_p.R382H|PML_uc002awr.2_Missense_Mutation_p.R382H|PML_uc002aws.2_Missense_Mutation_p.R382H|PML_uc002awt.2_Missense_Mutation_p.R382H|PML_uc002awu.2_Missense_Mutation_p.R382H|PML_uc010ule.1_Intron|PML_uc002aww.1_Missense_Mutation_p.R297H|PML_uc002awx.2_Missense_Mutation_p.R140H|PML_uc002awy.2_5'Flank	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	382					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						TTCAAGGTGCGCCTGCAGGAC	0.672			T	RARA|PAX5	APL|ALL							
ISLR2	57611	broad.mit.edu	37	15	74425791	74425791	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:74425791G>A	uc002axd.2	+	4	1465	c.696G>A	c.(694-696)CCG>CCA	p.P232P	ISLR2_uc002axe.2_Silent_p.P232P|ISLR2_uc010bjg.2_Silent_p.P232P|ISLR2_uc010bjf.2_Silent_p.P232P	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	232	Extracellular (Potential).|LRRCT.				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CCTGTGCACCGCCCAGCGTGC	0.706												
SIN3A	25942	broad.mit.edu	37	15	75692403	75692403	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:75692403C>T	uc002bai.2	-	12	2091	c.1832G>A	c.(1831-1833)CGT>CAT	p.R611H	SIN3A_uc002baj.2_Missense_Mutation_p.R611H|SIN3A_uc010uml.1_Missense_Mutation_p.R611H	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	611	Interactions with SUDS3 and SAP130.|Interaction with NCOR1 (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						ATCTTCACAACGATAAATATG	0.433												
IREB2	3658	broad.mit.edu	37	15	78780136	78780136	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:78780136G>A	uc002bdr.2	+	14	1933	c.1771G>A	c.(1771-1773)GCA>ACA	p.A591T	IREB2_uc010unb.1_Missense_Mutation_p.A341T	NM_004136	NP_004127	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	591							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		CTTATCAGACGCAGTTTTAAA	0.313												
RASGRF1	5923	broad.mit.edu	37	15	79356791	79356791	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:79356791G>A	uc002beq.2	-	2	729	c.354C>T	c.(352-354)GAC>GAT	p.D118D	RASGRF1_uc002bep.2_Silent_p.D118D|RASGRF1_uc010blm.1_Silent_p.D40D|RASGRF1_uc002ber.3_Silent_p.D118D	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	118	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CCACCCATTCGTCACAATCTT	0.532												
FAH	2184	broad.mit.edu	37	15	80452206	80452206	+	Missense_Mutation	SNP	G	G	A	rs11555097		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:80452206G>A	uc002bfj.2	+	4	383	c.301G>A	c.(301-303)GAA>AAA	p.E101K	FAH_uc002bfk.1_Missense_Mutation_p.E101K|FAH_uc002bfm.1_Missense_Mutation_p.E101K|FAH_uc002bfn.1_Missense_Mutation_p.E31K|FAH_uc010unl.1_Missense_Mutation_p.E101K|FAH_uc002bfl.1_Missense_Mutation_p.E101K	NM_000137	NP_000128	P16930	FAAA_HUMAN	fumarylacetoacetase	101					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding				0						AGATGACACCGAACTTCGGAA	0.572									Tyrosinemia_type_1			
ALPK3	57538	broad.mit.edu	37	15	85410563	85410563	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:85410563T>A	uc002ble.2	+	13	5512	c.5345T>A	c.(5344-5346)ATG>AAG	p.M1782K	ALPK3_uc010upc.1_Missense_Mutation_p.M83K	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1782	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GACTGGAAGATGACTGATGTG	0.527												
AKAP13	11214	broad.mit.edu	37	15	86189060	86189060	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:86189060T>C	uc002blv.1	+	10	4419	c.4249T>C	c.(4249-4251)TTC>CTC	p.F1417L	AKAP13_uc002blt.1_Missense_Mutation_p.F1417L|AKAP13_uc002blu.1_Missense_Mutation_p.F1417L|AKAP13_uc010bnf.1_Missense_Mutation_p.F57L|AKAP13_uc010bne.1_Missense_Mutation_p.F70L	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1417					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						ATGTGAGAACTTCCTGGATGT	0.348												
FES	2242	broad.mit.edu	37	15	91428314	91428314	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:91428314C>T	uc002bpv.2	+	2	135	c.39C>T	c.(37-39)CAC>CAT	p.H13H	FES_uc010uqj.1_Silent_p.H13H|FES_uc010uqk.1_Silent_p.H13H|FES_uc002bpw.2_RNA|FES_uc010bny.2_Silent_p.H13H|FES_uc002bpx.2_Silent_p.H13H|FES_uc002bpy.2_Silent_p.H13H	NM_002005	NP_001996	P07332	FES_HUMAN	feline sarcoma oncogene isoform 1	13	FCH.|Important for interaction with membranes containing phosphoinositides.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CCCAGGGCCACGGGGTCCTGC	0.617												
ADAMTS17	170691	broad.mit.edu	37	15	100695507	100695507	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:100695507G>A	uc002bvv.1	-	9	1279	c.1200C>T	c.(1198-1200)GAC>GAT	p.D400D	ADAMTS17_uc002bvx.1_Silent_p.D157D	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	400	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		AGTGGTCATCGTCGTGGTTCA	0.557												
ADAMTS17	170691	broad.mit.edu	37	15	100821466	100821466	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:100821466C>T	uc002bvv.1	-	4	836	c.757G>A	c.(757-759)GCC>ACC	p.A253T	ADAMTS17_uc002bvx.1_Missense_Mutation_p.A10T	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	253	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		AACCTCTGGGCGGCCTCGGCC	0.642												
LRRK1	79705	broad.mit.edu	37	15	101588759	101588759	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:101588759A>C	uc002bwr.2	+	22	3515	c.3196A>C	c.(3196-3198)ACA>CCA	p.T1066P	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_Intron	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1066					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTACAGTTTTACAGGAAACCA	0.423												
LUC7L	55692	broad.mit.edu	37	16	239997	239997	+	Missense_Mutation	SNP	C	C	T	rs146490197		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:239997C>T	uc002cgc.1	-	9	1055	c.944G>A	c.(943-945)CGG>CAG	p.R315Q	LUC7L_uc002cga.1_Missense_Mutation_p.R315Q|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_Missense_Mutation_p.R315Q|LUC7L_uc002cgb.1_Missense_Mutation_p.R229Q	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	315	Arg/Ser-rich.						metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				CCGGGAAGCCCGACGATGTCC	0.617												
UBE2I	7329	broad.mit.edu	37	16	1370217	1370217	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:1370217C>T	uc002clc.1	+	5	370	c.266C>T	c.(265-267)TCG>TTG	p.S89L	UBE2I_uc002cld.1_Missense_Mutation_p.S89L|UBE2I_uc002clf.1_Missense_Mutation_p.S89L|UBE2I_uc002clg.1_Missense_Mutation_p.S89L|UBE2I_uc002clh.1_Missense_Mutation_p.S89L|UBE2I_uc002cli.1_Missense_Mutation_p.S89L	NM_194261	NP_919237	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	89				VYPS -> GVPF (in Ref. 6; AAC50603).	cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|skin(1)	2		Hepatocellular(780;0.00369)				GTGTACCCTTCGGGGACAGTG	0.557												
GNPTG	84572	broad.mit.edu	37	16	1412640	1412640	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:1412640T>G	uc002clm.2	+	9	673	c.638T>G	c.(637-639)TTT>TGT	p.F213C		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma	213						extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				AGGACACTTTTTGAGGATGCT	0.602												
IFT140	9742	broad.mit.edu	37	16	1574907	1574907	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:1574907G>A	uc002cmb.2	-	23	3237	c.2875C>T	c.(2875-2877)CGG>TGG	p.R959W	IFT140_uc002clz.2_Missense_Mutation_p.R572W	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	959	TPR 4.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GCCCACCACCGCCACAGGGTC	0.697												
NUBP2	10101	broad.mit.edu	37	16	1837726	1837726	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:1837726A>G	uc002cmw.3	+	4	472	c.383A>G	c.(382-384)TAC>TGC	p.Y128C	NUBP2_uc002cmx.3_5'UTR|NUBP2_uc010brx.2_Missense_Mutation_p.Y68C	NM_012225	NP_036357	Q9Y5Y2	NUBP2_HUMAN	nucleotide binding protein 2 (MinD homolog, E.	128						microtubule organizing center|nucleus	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding|protein binding				0						GAGCTGGACTACCTGGTGGTG	0.672												
SLC9A3R2	9351	broad.mit.edu	37	16	2086453	2086453	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:2086453G>A	uc002coi.2	+	3	662	c.543G>A	c.(541-543)CCG>CCA	p.P181P	SLC9A3R2_uc002coj.2_Silent_p.P181P|SLC9A3R2_uc002cok.2_Silent_p.P70P	NM_001130012	NP_001123484	Q15599	NHRF2_HUMAN	solute carrier family 9 isoform 3 regulator 2	181	PDZ 2.				protein complex assembly	apical plasma membrane|endomembrane system|nucleus	beta-catenin binding|phosphatase binding|protein C-terminus binding|receptor binding			central_nervous_system(1)	1						CTGTGGACCCGGGCTCACCTG	0.697												
DNASE1	1773	broad.mit.edu	37	16	3706167	3706167	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:3706167C>T	uc002cvr.2	+	4	2408	c.301C>T	c.(301-303)CGC>TGC	p.R101C		NM_005223	NP_005214	P24855	DNAS1_HUMAN	deoxyribonuclease I precursor	101					apoptosis|DNA catabolic process	extracellular region|nuclear envelope	actin binding|deoxyribonuclease I activity				0		Ovarian(90;0.0261)		Kidney(780;0.0556)	Dornase Alfa(DB00003)	CTATAAGGAGCGCTACCTGTT	0.562								Direct_reversal_of_damage				
GLIS2	84662	broad.mit.edu	37	16	4384878	4384878	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:4384878C>G	uc002cwc.1	+	3	479	c.422C>G	c.(421-423)GCC>GGC	p.A141G		NM_032575	NP_115964	Q9BZE0	GLIS2_HUMAN	GLIS family zinc finger 2	141	Interaction with CTNND1 (By similarity).				cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development	cytoplasm|nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|transcription regulatory region DNA binding|zinc ion binding				0						TCCGGGGGGGCCCTGCACCTG	0.662												
CORO7	79585	broad.mit.edu	37	16	4409582	4409582	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:4409582G>T	uc002cwh.3	-	22	2269	c.2149C>A	c.(2149-2151)CTG>ATG	p.L717M	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.L717M|CORO7_uc002cwg.3_Missense_Mutation_p.L497M|CORO7_uc010uxh.1_Missense_Mutation_p.L699M|CORO7_uc010uxi.1_Missense_Mutation_p.L632M|CORO7_uc002cwi.1_Missense_Mutation_p.L497M	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	717						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						CCGCCGGCCAGGGCCTCAGCT	0.652											OREG0023580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
PPL	5493	broad.mit.edu	37	16	4933690	4933690	+	Missense_Mutation	SNP	G	G	A	rs140094738	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:4933690G>A	uc002cyd.1	-	22	5056	c.4966C>T	c.(4966-4968)CGC>TGC	p.R1656C		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1656	Plectin 1.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						ACGATGGAGCGCCGCAGGTGG	0.632												
ATF7IP2	80063	broad.mit.edu	37	16	10575765	10575765	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:10575765A>C	uc002czu.2	+	12	1935	c.1708A>C	c.(1708-1710)ACC>CCC	p.T570P	ATF7IP2_uc002czv.2_3'UTR|ATF7IP2_uc010uyo.1_RNA|ATF7IP2_uc010uyp.1_Missense_Mutation_p.T114P|ATF7IP2_uc002czw.2_Missense_Mutation_p.T570P|ATF7IP2_uc010uyq.1_RNA	NM_024997	NP_079273	Q5U623	MCAF2_HUMAN	activating transcription factor 7 interacting	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGTAGACAAAACCCGAGACAC	0.458												
ZC3H7A	29066	broad.mit.edu	37	16	11868230	11868230	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:11868230C>T	uc002dbk.2	-	8	963	c.765G>A	c.(763-765)CTG>CTA	p.L255L	ZC3H7A_uc002dbl.2_Silent_p.L255L|ZC3H7A_uc002dbm.1_Silent_p.L255L	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	255						nucleus	nucleic acid binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						CTGCAGATGGCAGAGCGCTCT	0.478												
PARN	5073	broad.mit.edu	37	16	14540788	14540788	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:14540788C>A	uc010uzd.1	-	23	1963	c.1821G>T	c.(1819-1821)AAG>AAT	p.K607N	PARN_uc010uzc.1_Missense_Mutation_p.K546N|PARN_uc010uze.1_Missense_Mutation_p.K561N|PARN_uc010uzf.1_Missense_Mutation_p.K432N	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation	607					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						ATTTCTTGGCCTTTTTCCTTC	0.498												
C16orf62	57020	broad.mit.edu	37	16	19710946	19710946	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:19710946C>T	uc002dgn.1	+	30	2781	c.2769C>T	c.(2767-2769)CAC>CAT	p.H923H	C16orf62_uc002dgo.1_Silent_p.H830H|C16orf62_uc002dgp.1_Silent_p.H672H	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	923						integral to membrane				ovary(1)	1						CACAGAGGCACGGCTGTGCAG	0.597												
PDILT	204474	broad.mit.edu	37	16	20373737	20373737	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:20373737C>T	uc002dhc.1	-	10	1628	c.1405G>A	c.(1405-1407)GGC>AGC	p.G469S		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	469					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TGTTGAGAGCCGCTGGGGAAC	0.488												
IGSF6	10261	broad.mit.edu	37	16	21663892	21663892	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:21663892C>T	uc002djg.1	-	1	81	c.28G>A	c.(28-30)GCT>ACT	p.A10T	uc002diq.3_Intron|METTL9_uc002dje.2_Intron|METTL9_uc002djf.2_Intron|IGSF6_uc010vbi.1_Missense_Mutation_p.A10T	NM_005849	NP_005840	O95976	IGSF6_HUMAN	immunoglobulin superfamily, member 6 precursor	10					cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0				GBM - Glioblastoma multiforme(48;0.066)		AGATGGCGAGCGATGTTGCTT	0.423												
TNRC6A	27327	broad.mit.edu	37	16	24817959	24817959	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:24817959T>C	uc002dmm.2	+	17	4508	c.4394T>C	c.(4393-4395)TTG>TCG	p.L1465S	TNRC6A_uc010bxs.2_Missense_Mutation_p.L1212S|TNRC6A_uc002dmn.2_Missense_Mutation_p.L1163S|TNRC6A_uc002dmo.2_Missense_Mutation_p.L1104S|TNRC6A_uc002dmp.2_Missense_Mutation_p.L66S|TNRC6A_uc002dmq.2_Missense_Mutation_p.L132S	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1465					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		CCAAACCTGTTGGTGAAGCAG	0.473												
GTF3C1	2975	broad.mit.edu	37	16	27475926	27475926	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:27475926G>A	uc002dov.1	-	34	5627	c.5587C>T	c.(5587-5589)CGC>TGC	p.R1863C	GTF3C1_uc002dou.2_Missense_Mutation_p.R1863C	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1863						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CAGCTGGCGCGCCTCTTGGTG	0.687												
ATXN2L	11273	broad.mit.edu	37	16	28846629	28846629	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:28846629C>G	uc002drc.2	+	20	2762	c.2594C>G	c.(2593-2595)GCC>GGC	p.A865G	uc010vct.1_Intron|ATXN2L_uc002drb.2_Missense_Mutation_p.A865G|ATXN2L_uc002dqy.2_Missense_Mutation_p.A865G|ATXN2L_uc002dra.2_Missense_Mutation_p.A865G|ATXN2L_uc002dqz.2_Missense_Mutation_p.A865G|ATXN2L_uc010vdb.1_Missense_Mutation_p.A871G|ATXN2L_uc002dre.2_Missense_Mutation_p.A865G|ATXN2L_uc002drf.2_Missense_Mutation_p.A274G|ATXN2L_uc002drg.2_Missense_Mutation_p.A147G	NM_007245	NP_009176	Q8WWM7	ATX2L_HUMAN	ataxin 2 related protein isoform A	865						membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CCACACCATGCCACACAGCTC	0.657												
SH2B1	25970	broad.mit.edu	37	16	28878130	28878130	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:28878130G>A	uc002dri.2	+	4	1154	c.715G>A	c.(715-717)GCC>ACC	p.A239T	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Missense_Mutation_p.A239T|SH2B1_uc002drk.2_Missense_Mutation_p.A239T|SH2B1_uc002drl.2_Missense_Mutation_p.A239T|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Missense_Mutation_p.A239T|SH2B1_uc002drm.2_Missense_Mutation_p.A239T	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	239	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Required for NGF signaling (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						GGGAGGGGGCGCCTTGAAGGA	0.642												
RABEP2	79874	broad.mit.edu	37	16	28925566	28925566	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:28925566C>T	uc002drq.2	-	5	933	c.885G>A	c.(883-885)CTG>CTA	p.L295L	uc010vct.1_Intron|RABEP2_uc010vdf.1_Silent_p.L224L|RABEP2_uc010byn.2_Silent_p.L295L|RABEP2_uc002drr.2_Silent_p.L295L	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	295	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CCTCTGTCTGCAGCTGCTCCC	0.637												
NFATC2IP	84901	broad.mit.edu	37	16	28970351	28970351	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:28970351C>T	uc002dru.2	+	7	1046	c.1031C>T	c.(1030-1032)ACG>ATG	p.T344M	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Missense_Mutation_p.T65M|NFATC2IP_uc002drv.2_Missense_Mutation_p.T63M|NFATC2IP_uc010vdh.1_Missense_Mutation_p.T52M	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	344						cytoplasm|nucleus				ovary(1)	1						GCCACAGAGACGTCCCAACAG	0.592												
ITGAL	3683	broad.mit.edu	37	16	30507880	30507880	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:30507880G>A	uc002dyi.3	+	15	2001	c.1825G>A	c.(1825-1827)GTG>ATG	p.V609M	ITGAL_uc002dyj.3_Missense_Mutation_p.V526M|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	609	FG-GAP 7.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CCAGATGATCGTGCTGAGGTG	0.453												
SRCAP	10847	broad.mit.edu	37	16	30732518	30732518	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:30732518T>C	uc002dze.1	+	21	3647	c.3262T>C	c.(3262-3264)TCC>CCC	p.S1088P	SRCAP_uc002dzf.2_Intron|SRCAP_uc002dzg.1_Missense_Mutation_p.S945P|SRCAP_uc010bzz.1_Missense_Mutation_p.S658P	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1088	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			AGTGTTGCCATCCCCCCTGGG	0.592												
SRCAP	10847	broad.mit.edu	37	16	30744953	30744953	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:30744953C>T	uc002dze.1	+	29	6713	c.6328C>T	c.(6328-6330)CGC>TGC	p.R2110C	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R1905C	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2110	Helicase C-terminal.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TGCAGACAAACGCATATTCTG	0.478												
ZNF646	9726	broad.mit.edu	37	16	31088883	31088883	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:31088883C>T	uc002eap.2	+	2	1527	c.1238C>T	c.(1237-1239)GCG>GTG	p.A413V		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	413	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						CTGTTCAATGCGGCTGCCCTC	0.587												
ITGAX	3687	broad.mit.edu	37	16	31371765	31371765	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:31371765T>C	uc002ebu.1	+	8	909	c.842T>C	c.(841-843)ATC>ACC	p.I281T	ITGAX_uc002ebt.2_Missense_Mutation_p.I281T|ITGAX_uc010vfk.1_5'Flank	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	281	VWFA.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCAGCAGGCATCATCCGCTAT	0.502												
ITGAX	3687	broad.mit.edu	37	16	31391664	31391664	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:31391664C>A	uc002ebu.1	+	27	3205	c.3138C>A	c.(3136-3138)ACC>ACA	p.T1046T	ITGAX_uc002ebt.2_Silent_p.T1046T	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	1046	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGGATTTCACCCTGAAGGGCA	0.632												
ORC6L	23594	broad.mit.edu	37	16	46731427	46731427	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:46731427A>G	uc002eeh.2	+	7	749	c.689A>G	c.(688-690)CAG>CGG	p.Q230R		NM_014321	NP_055136	Q9Y5N6	ORC6_HUMAN	origin recognition complex subunit 6	230					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA binding|protein binding				0		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GATCTGACACAGGATTATGAA	0.363												
ABCC12	94160	broad.mit.edu	37	16	48119514	48119514	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:48119514C>T	uc002efc.1	-	27	4164	c.3818G>A	c.(3817-3819)CGT>CAT	p.R1273H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	1273	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CTTTGAATTACGGAGAAGAGC	0.453												
ABCC12	94160	broad.mit.edu	37	16	48120729	48120729	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:48120729A>G	uc002efc.1	-	26	3983	c.3637T>C	c.(3637-3639)TAC>CAC	p.Y1213H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_Intron|ABCC12_uc002efa.1_Intron|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_Intron	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	1213	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TCCAAGTTGTACCTGCAATGA	0.532												
CBLN1	869	broad.mit.edu	37	16	49315194	49315194	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:49315194C>A	uc002efq.2	-	1	522	c.183G>T	c.(181-183)AAG>AAT	p.K61N		NM_004352	NP_004343	P23435	CBLN1_HUMAN	cerebellin 1 precursor	61	C1q.				nervous system development|synaptic transmission	cell junction|extracellular region|synapse					0		all_cancers(37;0.0766)|all_lung(18;0.24)				AGAAAGCCACCTTGGCGCTGC	0.617												
CYLD	1540	broad.mit.edu	37	16	50815288	50815288	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:50815288G>A	uc002egp.1	+	10	2065	c.1650G>A	c.(1648-1650)CCG>CCA	p.P550P	CYLD_uc002ego.2_Silent_p.P547P|CYLD_uc010cbs.1_Silent_p.P547P|CYLD_uc002egq.1_Silent_p.P547P|CYLD_uc002egr.1_Silent_p.P547P|CYLD_uc002egs.1_Silent_p.P547P	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	550	Interaction with TRIP.|Interaction with IKBKG/NEMO.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				CATTGCAGCCGGTTTCCAATC	0.438			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial			
RPGRIP1L	23322	broad.mit.edu	37	16	53682940	53682940	+	Missense_Mutation	SNP	C	C	T	rs142349647	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:53682940C>T	uc002ehp.2	-	16	2304	c.2240G>A	c.(2239-2241)CGA>CAA	p.R747Q	RPGRIP1L_uc002eho.3_Missense_Mutation_p.R747Q|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.R747Q|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.R747Q|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.R747Q	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	747					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TGCCCTTTCTCGATAAAGTCG	0.408												
IRX3	79191	broad.mit.edu	37	16	54318212	54318212	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:54318212G>A	uc002eht.1	-	3	1813	c.1397C>T	c.(1396-1398)GCC>GTC	p.A466V		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	466					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CACTTCCAAGGCACTACAGCG	0.622												
NLRC5	84166	broad.mit.edu	37	16	57060011	57060011	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:57060011C>T	uc002ekk.1	+	6	1381	c.1156C>T	c.(1156-1158)CGG>TGG	p.R386W	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.R191W|NLRC5_uc002ekl.2_Missense_Mutation_p.R191W|NLRC5_uc002ekm.2_Missense_Mutation_p.R191W|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	386	NACHT.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CCAGCCATCGCGGGAGGGGGC	0.552												
NLRC5	84166	broad.mit.edu	37	16	57060522	57060522	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:57060522G>A	uc002ekk.1	+	6	1892	c.1667G>A	c.(1666-1668)GGC>GAC	p.G556D	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Missense_Mutation_p.G361D|NLRC5_uc002ekl.2_Missense_Mutation_p.G361D|NLRC5_uc002ekm.2_Missense_Mutation_p.G361D|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	556					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				GCTAGACTGGGCCTCTCAGAC	0.622												
CPNE2	221184	broad.mit.edu	37	16	57181521	57181521	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:57181521A>G	uc002eks.1	+	16	1827	c.1598A>G	c.(1597-1599)CAG>CGG	p.Q533R	CPNE2_uc010cct.1_Missense_Mutation_p.Q559R|CPNE2_uc010ccu.1_Missense_Mutation_p.Q533R|CPNE2_uc002ekt.1_3'UTR	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	533										central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				CAAGTTGTGCAGTATTTCAAG	0.602												
CCDC135	84229	broad.mit.edu	37	16	57760011	57760011	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:57760011C>T	uc002emi.2	+	13	1879	c.1790C>T	c.(1789-1791)GCG>GTG	p.A597V	CCDC135_uc002emj.2_Missense_Mutation_p.A597V|CCDC135_uc002emk.2_Missense_Mutation_p.A532V	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	597						cytoplasm				central_nervous_system(1)	1						CGCAACCCAGCGAAGCCCGCG	0.607												
PRSS54	221191	broad.mit.edu	37	16	58324964	58324964	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:58324964C>T	uc002enf.2	-	4	557	c.162G>A	c.(160-162)CCG>CCA	p.P54P	PRSS54_uc002eng.2_Silent_p.P54P|PRSS54_uc010vie.1_Intron	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	54	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ACACCACCCACGGGAACTCCA	0.607												
CNOT1	23019	broad.mit.edu	37	16	58581500	58581500	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:58581500T>C	uc002env.2	-	26	3902	c.3609A>G	c.(3607-3609)ACA>ACG	p.T1203T	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.T1198T|CNOT1_uc002enx.2_Silent_p.T1203T|CNOT1_uc010vik.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1203					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TTTTAGCTAATGTGATCATTC	0.378												
CNOT1	23019	broad.mit.edu	37	16	58581512	58581512	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:58581512T>C	uc002env.2	-	26	3890	c.3597A>G	c.(3595-3597)CTA>CTG	p.L1199L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.L1194L|CNOT1_uc002enx.2_Silent_p.L1199L|CNOT1_uc010vik.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1199					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGATCATTCCTAGCCAATGTC	0.368												
CDH5	1003	broad.mit.edu	37	16	66436800	66436800	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:66436800G>A	uc002eom.3	+	12	2239	c.2083G>A	c.(2083-2085)GCG>ACG	p.A695T		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	695	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		ACCGAGGCACGCGCCTGGGGC	0.572												
NAE1	8883	broad.mit.edu	37	16	66847501	66847501	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:66847501C>T	uc002eqf.2	-	13	1077	c.1000G>A	c.(1000-1002)GCA>ACA	p.A334T	NAE1_uc002eqe.2_Missense_Mutation_p.A328T|NAE1_uc002eqg.2_Missense_Mutation_p.A245T|NAE1_uc010cdv.2_Missense_Mutation_p.A337T	NM_003905	NP_003896	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1 isoform a	334	Interaction with UBA3.				apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	CCTGAATCTGCAATCATATCA	0.343												
FHOD1	29109	broad.mit.edu	37	16	67268086	67268086	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:67268086G>A	uc002esl.2	-	13	1632	c.1520C>T	c.(1519-1521)GCC>GTC	p.A507V	FHOD1_uc010ced.2_Missense_Mutation_p.A314V|FHOD1_uc010vjh.1_Missense_Mutation_p.A167V	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	507	FH1.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GCTTCGCTGGGCCCGGAGCAG	0.647												
CDH1	999	broad.mit.edu	37	16	68835713	68835713	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:68835713G>A	uc002ewg.1	+	3	428	c.304G>A	c.(304-306)GCC>ACC	p.A102T	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.A102T	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	102					adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		CTTGGTCTACGCCTGGGACTC	0.512			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
ZNF19	7567	broad.mit.edu	37	16	71509780	71509780	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:71509780G>A	uc010cgc.1	-	6	1176	c.670C>T	c.(670-672)CGA>TGA	p.R224*	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Nonsense_Mutation_p.R212*|ZNF19_uc002fal.1_Nonsense_Mutation_p.R212*|ZNF19_uc002fam.1_Nonsense_Mutation_p.R224*	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	224	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		TTAAAGGCTCGCCCACACTCC	0.458												
ZFHX3	463	broad.mit.edu	37	16	72830135	72830135	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:72830135C>T	uc002fck.2	-	9	7119	c.6446G>A	c.(6445-6447)CGC>CAC	p.R2149H	ZFHX3_uc002fcl.2_Missense_Mutation_p.R1235H	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2149	Homeobox 1.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GATCCTGGTGCGAGGCCTCTT	0.547												
ZFHX3	463	broad.mit.edu	37	16	72984509	72984509	+	Silent	SNP	G	G	A	rs137984545	by1000genomes	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:72984509G>A	uc002fck.2	-	3	3748	c.3075C>T	c.(3073-3075)AAC>AAT	p.N1025N	ZFHX3_uc002fcl.2_Silent_p.N111N	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1025					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GCCTCCACTCGTTGGCCTTGC	0.597												
ZFHX3	463	broad.mit.edu	37	16	72993351	72993351	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:72993351G>A	uc002fck.2	-	2	1367	c.694C>T	c.(694-696)CGC>TGC	p.R232C	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	232					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TCAAACACGCGGAAGCTGTGC	0.557												
CHST5	23563	broad.mit.edu	37	16	75563418	75563418	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:75563418G>A	uc002fei.2	-	3	2260	c.865C>T	c.(865-867)CGC>TGC	p.R289C	CHST5_uc002fej.1_Missense_Mutation_p.R295C	NM_024533	NP_078809	Q9GZS9	CHST5_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	289	Lumenal (Potential).				N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGGCGGTAGCGGCCGCGCAGG	0.716												
KARS	3735	broad.mit.edu	37	16	75669691	75669691	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:75669691G>A	uc002feq.2	-	6	730	c.682C>T	c.(682-684)CGC>TGC	p.R228C	KARS_uc002fer.2_Missense_Mutation_p.R256C|KARS_uc002fes.2_Missense_Mutation_p.R72C|KARS_uc010cgz.2_Missense_Mutation_p.R72C	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	228					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	TATCTCTGGCGATACCTTGTT	0.393												
ADAMTS18	170692	broad.mit.edu	37	16	77369762	77369762	+	Missense_Mutation	SNP	C	C	T	rs149189203	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:77369762C>T	uc002ffc.3	-	12	2169	c.1750G>A	c.(1750-1752)GGG>AGG	p.G584R	ADAMTS18_uc010chc.1_Missense_Mutation_p.G172R|ADAMTS18_uc002ffe.1_Missense_Mutation_p.G280R	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	584					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GGCCGGGGCCCGAGCTCCCCA	0.587												
OSGIN1	29948	broad.mit.edu	37	16	83994222	83994222	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:83994222G>A	uc002fha.2	+	5	885	c.502G>A	c.(502-504)GTG>ATG	p.V168M	OSGIN1_uc002fhb.2_Missense_Mutation_p.V85M|OSGIN1_uc002fhc.2_Missense_Mutation_p.V85M	NM_013370	NP_037502	Q9UJX0	OSGI1_HUMAN	oxidative stress induced growth inhibitor 1	168					cell differentiation|multicellular organismal development|negative regulation of cell growth		growth factor activity				0						CCAAAGCCCCGTGGCCCTGCT	0.632												
MBTPS1	8720	broad.mit.edu	37	16	84088130	84088130	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:84088130G>A	uc002fhi.2	-	23	3585	c.3083C>T	c.(3082-3084)CCG>CTG	p.P1028L	MBTPS1_uc002fhh.2_Missense_Mutation_p.P532L	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	1028	Arg/Lys/Pro-rich (basic).|Cytoplasmic (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CCTCCGCTTCGGCCTGCTCTT	0.617												
MBTPS1	8720	broad.mit.edu	37	16	84100196	84100196	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:84100196C>T	uc002fhi.2	-	17	2753	c.2251G>A	c.(2251-2253)GGA>AGA	p.G751R	MBTPS1_uc002fhh.2_Missense_Mutation_p.G255R	NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	751	Lumenal (Potential).				cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						TTAGCTCCTCCGGTATCCGGC	0.517												
FOXF1	2294	broad.mit.edu	37	16	86544392	86544392	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:86544392G>A	uc002fjl.2	+	1	260	c.217G>A	c.(217-219)GAG>AAG	p.E73K	uc002fjk.1_5'Flank	NM_001451	NP_001442	Q12946	FOXF1_HUMAN	forkhead box F1	73	Fork-head.				branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0						GACGCTGAGCGAGATCTACCA	0.627												
ANKRD11	29123	broad.mit.edu	37	16	89351372	89351372	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:89351372G>A	uc002fmx.1	-	9	2039	c.1578C>T	c.(1576-1578)CAC>CAT	p.H526H	ANKRD11_uc002fmy.1_Silent_p.H526H|ANKRD11_uc002fnc.1_Silent_p.H526H|ANKRD11_uc002fnb.1_Silent_p.H483H	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	526	Ser-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CAGAGCTCCCGTGAGACGAGG	0.627												
CAMKK1	84254	broad.mit.edu	37	17	3786397	3786397	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:3786397A>G	uc002fwt.2	-	6	681	c.587T>C	c.(586-588)GTG>GCG	p.V196A	CAMKK1_uc002fwu.2_Missense_Mutation_p.V196A|CAMKK1_uc002fwv.2_Missense_Mutation_p.V196A	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	196	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		CTCCTGGTACACCCGCTCCAG	0.617												
ZZEF1	23140	broad.mit.edu	37	17	3926101	3926101	+	Missense_Mutation	SNP	G	G	A	rs149535137		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:3926101G>A	uc002fxe.2	-	44	7178	c.7114C>T	c.(7114-7116)CGT>TGT	p.R2372C	ZZEF1_uc002fxh.2_Missense_Mutation_p.R686C|ZZEF1_uc002fxi.2_Missense_Mutation_p.R607C	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2372							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAAGTAGCACGGATCTCCTCA	0.483												
MYBBP1A	10514	broad.mit.edu	37	17	4448573	4448573	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:4448573C>T	uc002fyb.3	-	16	2203	c.2141G>A	c.(2140-2142)CGG>CAG	p.R714Q	MYBBP1A_uc002fxz.3_Missense_Mutation_p.R714Q|MYBBP1A_uc002fya.3_5'Flank|MYBBP1A_uc010vsa.1_5'Flank	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	714					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						CTTCAGCCGCCGCTCATCAGA	0.657												
USP6	9098	broad.mit.edu	37	17	5041042	5041042	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:5041042C>T	uc002gau.1	+	20	3152	c.922C>T	c.(922-924)CAG>TAG	p.Q308*	USP6_uc002gav.1_Nonsense_Mutation_p.Q308*|USP6_uc010ckz.1_5'UTR|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	308					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						TAAGGTTCAGCAGAGTAAGTC	0.572			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts							
CLEC10A	10462	broad.mit.edu	37	17	6978516	6978516	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:6978516C>T	uc002gek.2	-	9	1111	c.808G>A	c.(808-810)GAC>AAC	p.D270N	CLEC10A_uc002gej.2_Missense_Mutation_p.D246N|CLEC10A_uc002gel.2_Missense_Mutation_p.D243N|CLEC10A_uc010clv.1_3'UTR	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	270	C-type lectin.|Extracellular (Potential).				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0						CCCTGCCAGTCGTCTGGCTGG	0.597												
DLG4	1742	broad.mit.edu	37	17	7106649	7106649	+	Splice_Site	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:7106649C>T	uc002get.3	-	9	1836	c.635_splice	c.e9-1	p.G212_splice	DLG4_uc010vtm.1_Splice_Site|DLG4_uc010vtn.1_Splice_Site_p.G109_splice|DLG4_uc010cly.2_Splice_Site_p.G166_splice|DLG4_uc010vto.1_Splice_Site_p.G209_splice|DLG4_uc002geu.2_Splice_Site_p.G166_splice	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1						axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						AAGCCAAGACCTGGATGGAGG	0.562												
TP53	7157	broad.mit.edu	37	17	7577121	7577121	+	Missense_Mutation	SNP	G	G	A	rs121913343		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:7577121G>A	uc002gim.2	-	8	1011	c.817C>T	c.(817-819)CGT>TGT	p.R273C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R273C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R141C|TP53_uc010cng.1_Missense_Mutation_p.R141C|TP53_uc002gii.1_Missense_Mutation_p.R141C|TP53_uc010cnh.1_Missense_Mutation_p.R273C|TP53_uc010cni.1_Missense_Mutation_p.R273C|TP53_uc002gij.2_Missense_Mutation_p.R273C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	273	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R273H(467)|p.R273C(396)|p.R273L(83)|p.R273P(24)|p.R273S(11)|p.R273G(9)|p.0?(7)|p.R273fs*72(3)|p.?(2)|p.R273fs*33(2)|p.F270fs*72(1)|p.R273_C275delRVC(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.R273R(1)|p.E258fs*71(1)|p.R273fs*71(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCACAAACACGCACCTCAAAG	0.542	R273C(SH10TC_STOMACH)|R273C(SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(8MGBA_CENTRAL_NERVOUS_SYSTEM)|R273C(SW1783_CENTRAL_NERVOUS_SYSTEM)|R273C(BL70_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(SW1710_URINARY_TRACT)|R273C(RH30_SOFT_TISSUE)|R273C(PANC0213_PANCREAS)|R273C(SJRH30_SOFT_TISSUE)|R273C(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(RDES_BONE)|R273C(TT2609C02_THYROID)|R273C(MFE319_ENDOMETRIUM)|R273C(RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R273C(EFO27_OVARY)|R273C(NCIH1048_LUNG)|R273C(KARPAS299_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
CHD3	1107	broad.mit.edu	37	17	7810789	7810789	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:7810789G>T	uc002gje.2	+	32	5057	c.4907G>T	c.(4906-4908)GGG>GTG	p.G1636V	CHD3_uc002gjd.2_Missense_Mutation_p.G1695V|CHD3_uc002gjf.2_Missense_Mutation_p.G1636V|CHD3_uc002gjh.2_Missense_Mutation_p.G212V|CHD3_uc002gjj.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1636	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GGGTACCGTGGGGACAGAGAG	0.577												
ALOX12B	242	broad.mit.edu	37	17	7978911	7978911	+	Splice_Site	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:7978911A>G	uc002gjy.1	-	12	1915	c.1654_splice	c.e12+1	p.G552_splice		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type						epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						CCAGGCCCATACCTGAGCTCT	0.587										Multiple Myeloma(8;0.094)		
TMEM107	84314	broad.mit.edu	37	17	8077915	8077915	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:8077915A>G	uc002gkg.3	-	4	386	c.276T>C	c.(274-276)AGT>AGC	p.S92S	TMEM107_uc002gkh.3_Silent_p.S98S|TMEM107_uc002gki.3_Silent_p.S98S|TMEM107_uc002gkj.3_Intron|TMEM107_uc002gkk.2_3'UTR	NM_183065	NP_898888	Q6UX40	TM107_HUMAN	transmembrane protein 107 isoform 2	92	Helical; (Potential).					integral to membrane					0						CCACGGATGCACTACAGTGAG	0.507												
MYH10	4628	broad.mit.edu	37	17	8393780	8393780	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:8393780C>T	uc002gll.2	-	33	4765	c.4669G>A	c.(4669-4671)GCC>ACC	p.A1557T	MYH10_uc002glm.2_Missense_Mutation_p.A1588T|MYH10_uc010cnx.2_Missense_Mutation_p.A1566T	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1557	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TCTTCCGTGGCCTGGAGTTCG	0.542												
WDR16	146845	broad.mit.edu	37	17	9515631	9515631	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:9515631T>A	uc002gly.2	+	8	929	c.860T>A	c.(859-861)ATT>AAT	p.I287N	WDR16_uc002glz.2_Missense_Mutation_p.I219N|WDR16_uc010coc.2_Missense_Mutation_p.I297N	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	287						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						TAAAGGAAGATTCAGTTACAA	0.428												
MYH8	4626	broad.mit.edu	37	17	10303844	10303844	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:10303844C>T	uc002gmm.2	-	27	3693	c.3598G>A	c.(3598-3600)GCA>ACA	p.A1200T	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1200	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						ATACTGTCTGCGTGCTTCTTC	0.547									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling			
MYH4	4622	broad.mit.edu	37	17	10355428	10355428	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:10355428C>T	uc002gmn.2	-	27	3679	c.3568G>A	c.(3568-3570)GAA>AAA	p.E1190K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1190	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GCCGTGGCTTCGTGCTGCAGG	0.582												
DNAH9	1770	broad.mit.edu	37	17	11713626	11713626	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:11713626A>G	uc002gne.2	+	45	8715	c.8647A>G	c.(8647-8649)ACT>GCT	p.T2883A	DNAH9_uc010coo.2_Missense_Mutation_p.T2177A	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2883	AAA 4 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTTTCTCATGACTGATGCCCA	0.448												
LLGL1	3996	broad.mit.edu	37	17	18140896	18140896	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:18140896C>T	uc002gsp.2	+	14	1774	c.1713C>T	c.(1711-1713)CAC>CAT	p.H571H		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	571	WD 9.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					GGAAGGGCCACGAGCGGCTGA	0.672												
LLGL1	3996	broad.mit.edu	37	17	18140961	18140961	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:18140961T>C	uc002gsp.2	+	14	1839	c.1778T>C	c.(1777-1779)GTG>GCG	p.V593A		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	593	WD 9.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					CGTGTCCTGGTGCAGTGCCTG	0.667												
FBXW10	10517	broad.mit.edu	37	17	18675757	18675757	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:18675757T>C	uc002guk.2	+	12	2271	c.2039T>C	c.(2038-2040)ATG>ACG	p.M680T	FBXW10_uc002guj.2_Missense_Mutation_p.M680T|FBXW10_uc002gul.2_Missense_Mutation_p.M709T|FBXW10_uc010cqh.1_Missense_Mutation_p.M627T	NM_031456	NP_113644	Q5XX13	FBW10_HUMAN	F-box and WD-40 domain protein 10	680										ovary(1)	1						AATGTTCTCATGTTCCAGTTT	0.353												
ALDOC	230	broad.mit.edu	37	17	26902512	26902512	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:26902512C>T	uc002hbp.2	-	2	184	c.39G>A	c.(37-39)AAG>AAA	p.K13K	ALDOC_uc010cro.2_Silent_p.K13K	NM_005165	NP_005156	P09972	ALDOC_HUMAN	fructose-bisphosphate aldolase C	13					fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis	cytosol	cytoskeletal protein binding|fructose-bisphosphate aldolase activity			ovary(1)	1	Lung NSC(42;0.00431)					ACAACTCCTTCTTCTGCTCAG	0.552											OREG0024278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
KIAA0100	9703	broad.mit.edu	37	17	26958520	26958520	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:26958520G>A	uc002hbu.2	-	23	4375	c.4276C>T	c.(4276-4278)CAT>TAT	p.H1426Y		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1426						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CGATTGCTATGCCGTTGGTAG	0.408												
FLOT2	2319	broad.mit.edu	37	17	27209367	27209367	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:27209367G>A	uc002hdc.2	-	6	690	c.567C>T	c.(565-567)GAC>GAT	p.D189D		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	189					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			GGATGCCTGCGTCCCGTTCAG	0.582												
NF1	4763	broad.mit.edu	37	17	29556992	29556992	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:29556992G>T	uc002hgg.2	+	22	3323	c.2990G>T	c.(2989-2991)AGG>ATG	p.R997M	NF1_uc002hgh.2_Missense_Mutation_p.R997M|NF1_uc010csn.1_Missense_Mutation_p.R857M|NF1_uc002hgi.1_Missense_Mutation_p.R30M	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	997					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)|p.R997fs*16(1)|p.R997K(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AATCTGGTCAGGTAAGCATTC	0.353			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)		
TMEM132E	124842	broad.mit.edu	37	17	32956140	32956140	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:32956140G>T	uc002hif.2	+	5	1313	c.985G>T	c.(985-987)GGC>TGC	p.G329C		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	329	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCGTGGCCACGGCGCCCTGCC	0.607												
SLFN5	162394	broad.mit.edu	37	17	33586176	33586176	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:33586176A>C	uc002hjf.3	+	2	584	c.467A>C	c.(466-468)CAG>CCG	p.Q156P	SLFN5_uc002hje.2_Missense_Mutation_p.Q156P|SLFN5_uc010wcg.1_Missense_Mutation_p.Q156P	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	156					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		TTAGGTCCACAGGCAGCTCAG	0.423												
CCL15	6359	broad.mit.edu	37	17	34324855	34324855	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:34324855C>A	uc010wcu.1	-	4	859	c.290G>T	c.(289-291)AGT>ATT	p.S97I	CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA	NM_032965	NP_116741	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15 precursor	97					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCCCGGACCACTGGGTTTGGC	0.512												
SYNRG	11276	broad.mit.edu	37	17	35902366	35902366	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:35902366C>T	uc002hoa.2	-	15	2993	c.2910G>A	c.(2908-2910)ACG>ACA	p.T970T	SYNRG_uc010wde.1_Silent_p.T892T|SYNRG_uc010wdf.1_Silent_p.T892T|SYNRG_uc002hoc.2_Silent_p.T891T|SYNRG_uc002hoe.2_Silent_p.T892T|SYNRG_uc002hod.2_Silent_p.T847T|SYNRG_uc010wdg.1_Silent_p.T764T|SYNRG_uc002hob.2_Silent_p.T970T|SYNRG_uc002hof.2_Silent_p.T636T	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	970					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						TCTGAGGAATCGTGTCTTTAA	0.458												
C17orf98	388381	broad.mit.edu	37	17	36997563	36997563	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:36997563C>T	uc002hqv.2	-	1	80	c.80G>A	c.(79-81)CGC>CAC	p.R27H		NM_001080465	NP_001073934	A8MV24	CQ098_HUMAN	hypothetical protein LOC388381	27											0						CCCATAAGCGCGGGCAGCGGT	0.632												
NR1D1	9572	broad.mit.edu	37	17	38253490	38253490	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:38253490G>A	uc002htz.1	-	2	824	c.198C>T	c.(196-198)CGC>CGT	p.R66R	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_5'Flank	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	66					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					TCCCAAAGGAGCGAGCCGGGT	0.463												
KRT27	342574	broad.mit.edu	37	17	38936090	38936090	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:38936090C>A	uc002hvg.2	-	4	749	c.708G>T	c.(706-708)GCG>GCT	p.A236A		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	236	Rod.|Linker 12.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				TGCCTCCAGCCGCGCACTGAA	0.433												
KRT12	3859	broad.mit.edu	37	17	39021080	39021080	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:39021080T>C	uc002hvk.2	-	3	809	c.785A>G	c.(784-786)TAC>TGC	p.Y262C		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	262	Rod.|Coil 1B.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CTTCTTCATGTAGGCCAGCTC	0.522												
KRT17	3872	broad.mit.edu	37	17	39776936	39776936	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:39776936G>A	uc002hxh.2	-	6	1277	c.1156C>T	c.(1156-1158)CGC>TGC	p.R386C	JUP_uc010wfs.1_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	386	Coil 2.|Rod.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				TCCAGCAGGCGGCGGTAGGTG	0.627									Steatocystoma_Multiplex			
NAGLU	4669	broad.mit.edu	37	17	40695811	40695811	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:40695811G>A	uc002hzv.2	+	6	2127	c.1787G>A	c.(1786-1788)GGC>GAC	p.G596D		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	596						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	AGGGCTGGAGGCGTCCTGGCC	0.642												
HSD17B1	3292	broad.mit.edu	37	17	40706500	40706500	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:40706500A>C	uc002hzw.2	+	5	1585	c.617A>C	c.(616-618)GAC>GCC	p.D206A	HSD17B1_uc002hzx.2_Missense_Mutation_p.D207A|HSD17B1_uc010wgm.1_RNA|uc002hzy.2_5'UTR|HSD17B1_uc010cyi.2_Missense_Mutation_p.D237A	NM_000413	NP_000404	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	206					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity				0		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	GAGGTGCTGGACCGCACGGAC	0.632												
PSMC3IP	29893	broad.mit.edu	37	17	40725006	40725006	+	Missense_Mutation	SNP	C	C	T	rs149230650		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:40725006C>T	uc002iai.2	-	8	677	c.634G>A	c.(634-636)GTC>ATC	p.V212I	MLX_uc002iaf.2_3'UTR|MLX_uc002iag.2_3'UTR|MLX_uc002iah.2_3'UTR|PSMC3IP_uc002iaj.2_Missense_Mutation_p.V149I|PSMC3IP_uc002iak.2_Missense_Mutation_p.V200I|PSMC3IP_uc010wgn.1_Missense_Mutation_p.V133I|PSMC3IP_uc010wgo.1_RNA|PSMC3IP_uc010wgp.1_RNA	NM_016556	NP_057640	Q9P2W1	HOP2_HUMAN	PSMC3 interacting protein isoform 2	212					DNA recombination|meiosis	nucleus	DNA binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(22;0.00426)|Breast(137;0.00116)|all_epithelial(22;0.0395)		BRCA - Breast invasive adenocarcinoma(366;0.13)		GGGAGTGTGACGTTGTAATCT	0.522												
AOC3	8639	broad.mit.edu	37	17	41003976	41003976	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:41003976C>T	uc002ibv.2	+	1	776	c.616C>T	c.(616-618)CGG>TGG	p.R206W		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	206	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	GCACCGGGGACGGAACCTGGT	0.577												
MPP2	4355	broad.mit.edu	37	17	41959879	41959879	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:41959879C>A	uc010wip.1	-	6	646	c.589G>T	c.(589-591)GGT>TGT	p.G197C	MPP2_uc002ien.1_Missense_Mutation_p.G169C|MPP2_uc010wim.1_Missense_Mutation_p.G141C|MPP2_uc002ieo.1_Missense_Mutation_p.G152C|MPP2_uc010win.1_Missense_Mutation_p.G13C|MPP2_uc010wio.1_Missense_Mutation_p.G141C|MPP2_uc010czm.1_Missense_Mutation_p.G135C	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	176					signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		AACGTTACACCCTGGAGGTCA	0.567												
MPP2	4355	broad.mit.edu	37	17	41975706	41975706	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:41975706G>A	uc010wip.1	-	3	266	c.209C>T	c.(208-210)GCC>GTC	p.A70V	MPP2_uc002ien.1_Missense_Mutation_p.A42V|MPP2_uc010wim.1_Missense_Mutation_p.A14V|MPP2_uc002ieo.1_Missense_Mutation_p.A25V|MPP2_uc010win.1_Intron|MPP2_uc010wio.1_Missense_Mutation_p.A14V|MPP2_uc010czm.1_Missense_Mutation_p.A14V	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	25	L27 1.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		AGCCCCCGTGGCACTGGGGAG	0.577												
HDAC5	10014	broad.mit.edu	37	17	42170162	42170162	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:42170162A>G	uc002ifd.1	-	7	865	c.654T>C	c.(652-654)CAT>CAC	p.H218H	HDAC5_uc002ife.1_Silent_p.H218H|HDAC5_uc002iff.1_Silent_p.H219H|HDAC5_uc010czp.1_Silent_p.H218H|HDAC5_uc002ifh.2_Silent_p.H218H	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	218					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		CCAAAGAAGCATGGTGGGCTC	0.612												
GPATCH8	23131	broad.mit.edu	37	17	42475277	42475277	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:42475277C>T	uc002igw.1	-	8	4232	c.4168G>A	c.(4168-4170)GCC>ACC	p.A1390T	GPATCH8_uc002igv.1_Missense_Mutation_p.A1312T|GPATCH8_uc010wiz.1_Missense_Mutation_p.A1312T	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1390	Poly-Ala.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ATGCCGATGGCGGCAGCAGCT	0.577												
NFE2L1	4779	broad.mit.edu	37	17	46136768	46136768	+	Missense_Mutation	SNP	G	G	A	rs144484468		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:46136768G>A	uc002imz.3	+	6	2735	c.2084G>A	c.(2083-2085)CGG>CAG	p.R695Q	NFE2L1_uc002ina.3_Missense_Mutation_p.R665Q|NFE2L1_uc002inb.3_Missense_Mutation_p.R665Q|NFE2L1_uc010wle.1_Missense_Mutation_p.R507Q|NFE2L1_uc010wlf.1_Missense_Mutation_p.R539Q	NM_003204	NP_003195	Q14494	NF2L1_HUMAN	nuclear factor erythroid 2-like 1	695	Leucine-zipper.				anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			skin(1)	1						GACAAAGCCCGGCTGCTGCGG	0.607												
HOXB13	10481	broad.mit.edu	37	17	46805700	46805700	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:46805700C>T	uc002ioa.2	-	1	412	c.256G>A	c.(256-258)GGG>AGG	p.G86R		NM_006361	NP_006352	Q92826	HXB13_HUMAN	homeobox B13	86					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GAGTAGTACCCGCCTCCAAAG	0.687												
MYST2	11143	broad.mit.edu	37	17	47869286	47869286	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:47869286C>T	uc002ipm.2	+	2	180	c.54C>T	c.(52-54)TCC>TCT	p.S18S	MYST2_uc002ipl.1_Silent_p.S18S|MYST2_uc010wma.1_Silent_p.S18S|MYST2_uc010wmb.1_Silent_p.S18S|MYST2_uc010wmc.1_Silent_p.S18S|MYST2_uc010wmd.1_5'UTR|MYST2_uc010wme.1_5'UTR	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	18	Ser-rich.				DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CCGAAGATTCCGATTTTTCTA	0.473												
CACNA1G	8913	broad.mit.edu	37	17	48668860	48668860	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:48668860C>T	uc002irk.1	+	11	2890	c.2518C>T	c.(2518-2520)CGT>TGT	p.R840C	CACNA1G_uc002iri.1_Missense_Mutation_p.R840C|CACNA1G_uc002irj.1_Missense_Mutation_p.R840C|CACNA1G_uc002irl.1_Missense_Mutation_p.R840C|CACNA1G_uc002irm.1_Missense_Mutation_p.R840C|CACNA1G_uc002irn.1_Missense_Mutation_p.R840C|CACNA1G_uc002iro.1_Missense_Mutation_p.R840C|CACNA1G_uc002irp.1_Missense_Mutation_p.R840C|CACNA1G_uc002irq.1_Missense_Mutation_p.R840C|CACNA1G_uc002irr.1_Missense_Mutation_p.R840C|CACNA1G_uc002irs.1_Missense_Mutation_p.R840C|CACNA1G_uc002irt.1_Missense_Mutation_p.R840C|CACNA1G_uc002irv.1_Missense_Mutation_p.R840C|CACNA1G_uc002irw.1_Missense_Mutation_p.R840C|CACNA1G_uc002iru.1_Missense_Mutation_p.R840C|CACNA1G_uc002irx.1_Missense_Mutation_p.R753C|CACNA1G_uc002iry.1_Missense_Mutation_p.R753C|CACNA1G_uc002irz.1_Missense_Mutation_p.R753C|CACNA1G_uc002isa.1_Missense_Mutation_p.R753C|CACNA1G_uc002isb.1_Missense_Mutation_p.R753C|CACNA1G_uc002isc.1_Missense_Mutation_p.R753C|CACNA1G_uc002isd.1_Missense_Mutation_p.R753C|CACNA1G_uc002ise.1_Missense_Mutation_p.R753C|CACNA1G_uc002isf.1_Missense_Mutation_p.R753C|CACNA1G_uc002isg.1_Missense_Mutation_p.R753C|CACNA1G_uc002ish.1_Missense_Mutation_p.R753C|CACNA1G_uc002isi.1_Missense_Mutation_p.R753C	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	840	Helical; Name=S4 of repeat II; (Potential).|II.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCGCCTGATGCGTGTGCTGAA	0.667												
GDPD1	284161	broad.mit.edu	37	17	57351092	57351092	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:57351092T>A	uc002ixk.1	+	10	1040	c.903T>A	c.(901-903)TAT>TAA	p.Y301*		NM_182569	NP_872375	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain	301	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					TGACAGACTATCCAACAAAGC	0.318												
TACO1	51204	broad.mit.edu	37	17	61685281	61685281	+	Silent	SNP	C	C	T	rs151139810	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:61685281C>T	uc002jbd.2	+	5	1013	c.813C>T	c.(811-813)CCC>CCT	p.P271P		NM_016360	NP_057444	Q9BSH4	TACO1_HUMAN	translational activator of mitochondrially	271					regulation of translation	mitochondrion					0						TGGCTGAGCCCGACCTGGAAC	0.542												
FTSJ3	117246	broad.mit.edu	37	17	61897300	61897300	+	Silent	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:61897300T>A	uc002jbz.2	-	20	2484	c.2406A>T	c.(2404-2406)GTA>GTT	p.V802V	FTSJ3_uc002jca.2_Silent_p.V802V	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	802					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						CTTTTTTGGCTACAACGTAGG	0.542												
CCDC45	90799	broad.mit.edu	37	17	62527046	62527046	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:62527046G>A	uc002jem.2	+	13	1507	c.1449G>A	c.(1447-1449)GCG>GCA	p.A483A	CCDC45_uc002jen.2_RNA|CCDC45_uc010wqb.1_Silent_p.A319A|CCDC45_uc002jeo.1_5'Flank	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	coiled-coil domain containing 45	483						centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			CCCTTTAGGCGTTTACTGAAG	0.284												
CACNG4	27092	broad.mit.edu	37	17	65020985	65020985	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:65020985G>A	uc002jft.1	+	3	329	c.314G>A	c.(313-315)CGA>CAA	p.R105Q		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	105	Extracellular (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			GGCATCGTGCGAGCCTCCAGC	0.637												
CACNG4	27092	broad.mit.edu	37	17	65027085	65027085	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:65027085G>A	uc002jft.1	+	4	964	c.949G>A	c.(949-951)GTC>ATC	p.V317I		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	317	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			AGGTTTCCACGTCAGCATGCT	0.607												
ARSG	22901	broad.mit.edu	37	17	66391298	66391298	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:66391298C>T	uc002jhc.2	+	10	1972	c.1176C>T	c.(1174-1176)TCC>TCT	p.S392S	ARSG_uc002jhb.1_Silent_p.S228S	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	392					sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGGACGTCTCCGAGGTGCTCT	0.582												
CD300E	342510	broad.mit.edu	37	17	72613483	72613483	+	Silent	SNP	G	G	A	rs111412583	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:72613483G>A	uc002jlb.1	-	2	203	c.162C>T	c.(160-162)TAC>TAT	p.Y54Y		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	54	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						ATGACGTGTCGTACTGTCCTC	0.562												
TMEM104	54868	broad.mit.edu	37	17	72832455	72832455	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:72832455G>A	uc002jls.3	+	10	1282	c.1120G>A	c.(1120-1122)GTG>ATG	p.V374M	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Missense_Mutation_p.V374M	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	374	Helical; (Potential).					integral to membrane					0	all_lung(278;0.23)					CATCATTGCCGTGACCCTGCG	0.637												
GGA3	23163	broad.mit.edu	37	17	73239539	73239539	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:73239539A>G	uc002jni.1	-	5	422	c.413T>C	c.(412-414)CTG>CCG	p.L138P	GGA3_uc002jnj.1_Missense_Mutation_p.L105P|GGA3_uc010wrw.1_Missense_Mutation_p.L16P|GGA3_uc002jnk.1_Missense_Mutation_p.L66P|GGA3_uc010wrx.1_Missense_Mutation_p.L16P|GGA3_uc010wry.1_Missense_Mutation_p.L66P|GGA3_uc010wrz.1_Missense_Mutation_p.L105P	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	138	VHS.|Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			CTGTCTCTTCAGCATGTGGTA	0.572												
EVPL	2125	broad.mit.edu	37	17	74005351	74005351	+	Missense_Mutation	SNP	G	G	A	rs145535523		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:74005351G>A	uc002jqi.2	-	22	4163	c.3935C>T	c.(3934-3936)ACG>ATG	p.T1312M	EVPL_uc010wss.1_Missense_Mutation_p.T1334M|EVPL_uc010wst.1_Missense_Mutation_p.T782M	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1312	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CTTGCTCACCGTCTTGGTCTC	0.692												
EVPL	2125	broad.mit.edu	37	17	74005498	74005498	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:74005498C>T	uc002jqi.2	-	22	4016	c.3788G>A	c.(3787-3789)AGC>AAC	p.S1263N	EVPL_uc010wss.1_Missense_Mutation_p.S1285N|EVPL_uc010wst.1_Missense_Mutation_p.S733N	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1263	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						CACCTCGGGGCTCCTCTCATG	0.662												
RNF213	57674	broad.mit.edu	37	17	78313974	78313974	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:78313974A>G	uc002jyh.1	+	1	249	c.26A>G	c.(25-27)CAC>CGC	p.H9R		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GACTGGGAGCACTGCTACCTC	0.622												
BAIAP2	10458	broad.mit.edu	37	17	79077502	79077502	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:79077502C>T	uc002jzg.2	+	8	951	c.843C>T	c.(841-843)CCC>CCT	p.P281P	BAIAP2_uc002jyz.3_Silent_p.P281P|BAIAP2_uc002jza.2_Silent_p.P281P|BAIAP2_uc002jzc.2_Silent_p.P281P|BAIAP2_uc002jzb.2_Silent_p.P38P|BAIAP2_uc002jzd.2_Silent_p.P281P|BAIAP2_uc002jzf.2_Silent_p.P281P|BAIAP2_uc002jze.2_Silent_p.P314P|BAIAP2_uc010wuh.1_Silent_p.P203P|BAIAP2_uc002jzh.2_Silent_p.P282P|BAIAP2_uc010wui.1_Silent_p.P144P	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	281					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CGGTGCCCCCCGAGCTGGCAC	0.701												
FOXK2	3607	broad.mit.edu	37	17	80521332	80521332	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:80521332C>T	uc002kfn.2	+	2	693	c.522C>T	c.(520-522)GCC>GCT	p.A174A	FOXK2_uc002kfm.1_Silent_p.A174A|FOXK2_uc010diu.2_Silent_p.A174A	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	174					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			CAGTGAAGGCCGTACAGCCAC	0.587												
FN3K	64122	broad.mit.edu	37	17	80708606	80708606	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:80708606G>A	uc010wvs.1	+	6	966	c.905G>A	c.(904-906)GGC>GAC	p.G302D	TBCD_uc002kfx.1_5'Flank|TBCD_uc002kfy.1_5'Flank|TBCD_uc002kfz.2_5'Flank	NM_022158	NP_071441	Q9H479	FN3K_HUMAN	fructosamine 3 kinase	302					fructoselysine metabolic process		fructosamine-3-kinase activity				0	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			CCTTCCTTGGGCACCATGCGA	0.413												
DLGAP1	9229	broad.mit.edu	37	18	3879216	3879216	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:3879216C>T	uc002kmf.2	-	1	920	c.853G>A	c.(853-855)GTG>ATG	p.V285M	DLGAP1_uc010wyz.1_Missense_Mutation_p.V285M|DLGAP1_uc002kmk.2_Missense_Mutation_p.V285M|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	285					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GCCCGGCTCACGGTGAGCGTG	0.637												
TXNDC2	84203	broad.mit.edu	37	18	9887885	9887885	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:9887885T>C	uc002koi.3	+	2	1858	c.1409T>C	c.(1408-1410)CTG>CCG	p.L470P	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.L403P	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	470	Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GGGGAGAGGCTGGTGGCTGTG	0.572												
NAPG	8774	broad.mit.edu	37	18	10532792	10532792	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:10532792C>T	uc002kon.2	+	3	436	c.209C>T	c.(208-210)GCT>GTT	p.A70V	NAPG_uc010wzr.1_5'UTR|NAPG_uc002koo.2_Intron	NM_003826	NP_003817	Q99747	SNAG_HUMAN	N-ethylmaleimide-sensitive factor attachment	70					cellular membrane fusion|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein complex assembly|protein stabilization	membrane|membrane fraction|mitochondrion	protein binding				0						AATAATAGGGCGTATCTTTTT	0.323												
IMPA2	3613	broad.mit.edu	37	18	12028085	12028085	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:12028085T>C	uc002kqp.1	+	6	748	c.534T>C	c.(532-534)CGT>CGC	p.R178R	IMPA2_uc002kqo.1_5'UTR|IMPA2_uc002kqq.1_Silent_p.R58R	NM_014214	NP_055029	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	178					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(2)	2					Lithium(DB01356)	GCCCCAAACGTGACCCTGCGA	0.512												
SNRPD1	6632	broad.mit.edu	37	18	19203788	19203788	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:19203788G>A	uc002ktj.1	+	3	302	c.171G>A	c.(169-171)ACG>ACA	p.T57T		NM_006938	NP_008869	P62314	SMD1_HUMAN	small nuclear ribonucleoprotein D1 polypeptide	57					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	catalytic step 2 spliceosome|cytosol|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	protein binding|RNA binding				0						AGCTGGAAACGCTGAGTATTC	0.388												
ASXL3	80816	broad.mit.edu	37	18	31323629	31323629	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:31323629A>G	uc010dmg.1	+	12	3872	c.3817A>G	c.(3817-3819)ACA>GCA	p.T1273A	ASXL3_uc002kxq.2_Missense_Mutation_p.T980A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1273	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TGCAAACACTACAATTTCTGC	0.388												
ASXL3	80816	broad.mit.edu	37	18	31325578	31325578	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:31325578C>T	uc010dmg.1	+	12	5821	c.5766C>T	c.(5764-5766)GAC>GAT	p.D1922D	ASXL3_uc002kxq.2_Silent_p.D1629D	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1922					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCCACACTGACGCTGGTACCT	0.547												
FHOD3	80206	broad.mit.edu	37	18	34174816	34174816	+	Missense_Mutation	SNP	G	G	A	rs144223411		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:34174816G>A	uc002kzt.1	+	7	770	c.673G>A	c.(673-675)GCA>ACA	p.A225T	FHOD3_uc002kzr.1_Missense_Mutation_p.A225T|FHOD3_uc002kzs.1_Missense_Mutation_p.A225T|FHOD3_uc002kzu.1_Missense_Mutation_p.A50T|FHOD3_uc010dmz.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	225	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GGAGTCCAACGCACCTCTCCT	0.517												
KIAA1632	57724	broad.mit.edu	37	18	43446902	43446902	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:43446902T>C	uc002lbm.2	-	38	6582	c.6482A>G	c.(6481-6483)TAC>TGC	p.Y2161C	KIAA1632_uc010xcq.1_Missense_Mutation_p.Y715C|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.Y1036C	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2161					autophagy						0						CACACTCTGGTACGACACAAT	0.398												
ST8SIA5	29906	broad.mit.edu	37	18	44336460	44336460	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:44336460C>T	uc002lcj.1	-	1	580	c.12G>A	c.(10-12)GCG>GCA	p.A4A	ST8SIA5_uc010xcy.1_Silent_p.A4A|ST8SIA5_uc010xcz.1_Silent_p.A4A|ST8SIA5_uc010dno.1_Silent_p.A4A	NM_013305	NP_037437	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide	4	Cytoplasmic (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						CCGAGGGGTCCGCGTAGCGCA	0.453												
POLI	11201	broad.mit.edu	37	18	51820306	51820306	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:51820306C>A	uc002lfj.3	+	10	1760	c.1692C>A	c.(1690-1692)GCC>GCA	p.A564A	POLI_uc010xds.1_Silent_p.A485A|POLI_uc002lfk.3_Silent_p.A461A|POLI_uc010dpg.2_Silent_p.A160A	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	564					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		CATTACATGCCTCTAGAGGAG	0.353								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage				
WDR7	23335	broad.mit.edu	37	18	54339760	54339760	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:54339760G>T	uc002lgk.1	+	2	225	c.14G>T	c.(13-15)AGC>ATC	p.S5I	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.S5I	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	5										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GCAGGAAACAGCCTTGTTCTA	0.378												
WDR7	23335	broad.mit.edu	37	18	54358513	54358513	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:54358513G>T	uc002lgk.1	+	8	995	c.784G>T	c.(784-786)GGG>TGG	p.G262W	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.G262W	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	262										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GACATGGACCGGGGGGGACTT	0.418												
WDR7	23335	broad.mit.edu	37	18	54424292	54424292	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:54424292G>A	uc002lgk.1	+	15	2679	c.2468G>A	c.(2467-2469)CGC>CAC	p.R823H	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.R823H	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	823										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TGCCTGGATCGCCTTGGAATG	0.468												
WDR7	23335	broad.mit.edu	37	18	54424475	54424475	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:54424475G>A	uc002lgk.1	+	15	2862	c.2651G>A	c.(2650-2652)CGT>CAT	p.R884H	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.R884H	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	884										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GGAGTGTCCCGTGCCGTCACC	0.443												
CDH20	28316	broad.mit.edu	37	18	59221656	59221656	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:59221656G>A	uc010dps.1	+	11	2146	c.2134G>A	c.(2134-2136)GTG>ATG	p.V712M	CDH20_uc002lif.2_Missense_Mutation_p.V706M	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	712	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				CTCCCGCTACGTGCCTCAGAC	0.682												
RNF152	220441	broad.mit.edu	37	18	59483442	59483442	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:59483442G>A	uc002lih.1	-	2	667	c.255C>T	c.(253-255)TCC>TCT	p.S85S		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	85					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				GGGTGTGTTCGGAAGTGTGTG	0.642												
PHLPP1	23239	broad.mit.edu	37	18	60645690	60645690	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:60645690G>A	uc002lis.2	+	18	2822	c.2644G>A	c.(2644-2646)GAT>AAT	p.D882N		NM_194449	NP_919431	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein	1394	PP2C-like.				apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity				0						CAACGTGCCCGATGCCCTGGC	0.627												
TSHZ1	10194	broad.mit.edu	37	18	72999537	72999537	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:72999537C>T	uc002lly.2	+	2	2603	c.2040C>T	c.(2038-2040)AAC>AAT	p.N680N		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	725						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		AGGTCACCAACGGCTGTAACA	0.577												
PTBP1	5725	broad.mit.edu	37	19	804843	804843	+	Silent	SNP	C	C	T	rs147803014		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:804843C>T	uc002lpr.2	+	7	727	c.621C>T	c.(619-621)TTC>TTT	p.F207F	PTBP1_uc002lpp.2_Silent_p.F207F|PTBP1_uc002lpq.2_Silent_p.F207F|PTBP1_uc002lps.2_Intron|PTBP1_uc002lpt.2_RNA|PTBP1_uc002lpu.1_Silent_p.F177F	NM_031991	NP_114368	P26599	PTBP1_HUMAN	polypyrimidine tract-binding protein 1 isoform	207	RRM 2.				negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			kidney(1)|skin(1)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTCCAAGTTCGGCACAGTGT	0.627												
DAZAP1	26528	broad.mit.edu	37	19	1428885	1428885	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:1428885G>A	uc002lsn.2	+	8	780	c.591G>A	c.(589-591)GCG>GCA	p.A197A	DAZAP1_uc002lsm.2_Silent_p.A197A|DAZAP1_uc002lso.2_Silent_p.A196A|DAZAP1_uc002lsl.1_Silent_p.A197A	NM_018959	NP_061832	Q96EP5	DAZP1_HUMAN	DAZ associated protein 1 isoform b	197					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)	1		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGCCAAGCGCCGGGACAGC	0.657												
APC2	10297	broad.mit.edu	37	19	1466805	1466805	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:1466805G>T	uc002lsr.1	+	15	3713	c.3505G>T	c.(3505-3507)GGC>TGC	p.G1169C	APC2_uc002lss.1_Missense_Mutation_p.G751C|APC2_uc002lst.1_Missense_Mutation_p.G1169C|APC2_uc002lsu.1_Missense_Mutation_p.G1168C|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1169	Interaction with CTNNB1.|2.|Ser-rich.|5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGCTCGCTGGGCAGCTTCGA	0.682												
MOBKL2A	126308	broad.mit.edu	37	19	2076887	2076887	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:2076887C>T	uc002luu.2	-	2	706	c.547G>A	c.(547-549)GTG>ATG	p.V183M	MOBKL2A_uc002luv.2_Missense_Mutation_p.V183M	NM_130807	NP_570719	Q96BX8	MOL2A_HUMAN	MOB-LAK	183						intracellular	metal ion binding			lung(1)	1		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGTGTTCACGTGGGCCTCG	0.612												
C19orf29	58509	broad.mit.edu	37	19	3612132	3612132	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:3612132C>T	uc002lyh.2	-	10	2119	c.2066G>A	c.(2065-2067)CGC>CAC	p.R689H	C19orf29_uc010xho.1_Missense_Mutation_p.R148H|C19orf29_uc010dtn.2_Missense_Mutation_p.R537H|C19orf29_uc002lyi.3_Missense_Mutation_p.R689H|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	689						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCGTGGAGCGCTTGTCGAT	0.577												
PIP5K1C	23396	broad.mit.edu	37	19	3641788	3641788	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:3641788C>T	uc002lyj.1	-	15	1759	c.1702G>A	c.(1702-1704)GCG>ACG	p.A568T	PIP5K1C_uc010xhq.1_Missense_Mutation_p.A568T|PIP5K1C_uc010xhr.1_Missense_Mutation_p.A568T	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	568					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		TCCTCTTCCGCGGGTGGCTCC	0.637												
PIP5K1C	23396	broad.mit.edu	37	19	3653507	3653507	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:3653507G>A	uc002lyj.1	-	7	759	c.702C>T	c.(700-702)CGC>CGT	p.R234R	PIP5K1C_uc010xhq.1_Silent_p.R234R|PIP5K1C_uc010xhr.1_Silent_p.R234R	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	234	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		TGACCACGACGCGGATGTTCT	0.612												
TJP3	27134	broad.mit.edu	37	19	3736172	3736172	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:3736172C>T	uc010xhv.1	+	10	1236	c.1236C>T	c.(1234-1236)CCC>CCT	p.P412P	TJP3_uc010xhs.1_Silent_p.P379P|TJP3_uc010xht.1_Silent_p.P343P|TJP3_uc010xhu.1_Silent_p.P388P|TJP3_uc010xhw.1_Silent_p.P398P	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	393						tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTACAGCCCCGACACGCGTG	0.662												
ZFR2	23217	broad.mit.edu	37	19	3831668	3831668	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:3831668G>A	uc002lyw.2	-	4	600	c.588C>T	c.(586-588)ACC>ACT	p.T196T	ZFR2_uc010xhx.1_RNA	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	196	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		CCGTGTAGGCGGTGCAGGTGG	0.627												
PLIN4	729359	broad.mit.edu	37	19	4512339	4512339	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:4512339C>T	uc002mar.1	-	3	1591	c.1591G>A	c.(1591-1593)GTG>ATG	p.V531M	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	531	27 X 33 AA approximate tandem repeat.|14.					lipid particle|plasma membrane					0						CCTTTGGCCACGTTCACAGCA	0.617												
SEMA6B	10501	broad.mit.edu	37	19	4550844	4550844	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:4550844G>A	uc010duc.1	-	10	1126	c.1088C>T	c.(1087-1089)ACG>ATG	p.T363M	SEMA6B_uc010dud.2_Missense_Mutation_p.T363M|SEMA6B_uc010xih.1_Missense_Mutation_p.T363M	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	363	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCACCGGCGTCCAGATGGA	0.652												
SEMA6B	10501	broad.mit.edu	37	19	4554436	4554436	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:4554436G>T	uc010duc.1	-	8	773	c.735C>A	c.(733-735)TTC>TTA	p.F245L	SEMA6B_uc010dud.2_Missense_Mutation_p.F245L|SEMA6B_uc010xih.1_Missense_Mutation_p.F245L	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	245	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CAATCTCCCGGAAGAAGAAGT	0.567												
PLIN3	10226	broad.mit.edu	37	19	4859941	4859941	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:4859941C>T	uc002mbj.2	-	3	339	c.162G>A	c.(160-162)CCG>CCA	p.P54P	PLIN3_uc002mbk.2_Silent_p.P54P|PLIN3_uc002mbl.3_Silent_p.P54P	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	54					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TCTTGATGTGCGGGTAGCTCT	0.637												
UHRF1	29128	broad.mit.edu	37	19	4954817	4954817	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:4954817C>T	uc002mbo.2	+	17	2282	c.2114C>T	c.(2113-2115)CCG>CTG	p.P705L	UHRF1_uc010xik.1_RNA|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.P718L	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	705					cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		AAGGACCGGCCGGCGAGCGGC	0.498												
INSR	3643	broad.mit.edu	37	19	7122772	7122772	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:7122772G>A	uc002mgd.1	-	19	3491	c.3382C>T	c.(3382-3384)CGC>TGC	p.R1128C	INSR_uc002mge.1_Missense_Mutation_p.R1116C	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1128	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGGGGAGGGCGGCCAGGATTA	0.587												
ZNF358	140467	broad.mit.edu	37	19	7585781	7585781	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:7585781C>T	uc002mgn.2	+	2	1823	c.1653C>T	c.(1651-1653)GGC>GGT	p.G551G	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	551					embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						TCCCTACCGGCGAGAGTCCAG	0.652												
KIAA1543	57662	broad.mit.edu	37	19	7682715	7682715	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:7682715G>A	uc002mgv.3	+	17	3623	c.3522G>A	c.(3520-3522)ACG>ACA	p.T1174T	KIAA1543_uc002mgu.3_Silent_p.T1201T|KIAA1543_uc002mgw.2_Silent_p.T304T	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	1174	CKK.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						CGCTCTACACGCTGTCGGGGG	0.612												
MAP2K7	5609	broad.mit.edu	37	19	7975196	7975196	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:7975196G>A	uc002mit.2	+	4	450	c.385G>A	c.(385-387)GGC>AGC	p.G129S	MAP2K7_uc002miv.2_Missense_Mutation_p.G129S|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.G129S|MAP2K7_uc010dvv.2_Missense_Mutation_p.G4S	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	129	Protein kinase.|ATP (By similarity).				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	GATGGGCAGCGGCACCTGCGG	0.672												
MAP2K7	5609	broad.mit.edu	37	19	7975348	7975348	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:7975348G>A	uc002mit.2	+	5	523	c.458G>A	c.(457-459)CGC>CAC	p.R153H	MAP2K7_uc002miv.2_Missense_Mutation_p.R153H|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.R153H|MAP2K7_uc010dvv.2_Missense_Mutation_p.R28H	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	153	Protein kinase.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	CAAATGCGGCGCTCCGGGAAC	0.637												
MAP2K7	5609	broad.mit.edu	37	19	7976201	7976201	+	Missense_Mutation	SNP	C	C	A	rs56278855		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:7976201C>A	uc002mit.2	+	8	987	c.922C>A	c.(922-924)CTG>ATG	p.L308M	MAP2K7_uc002miv.2_Missense_Mutation_p.L308M|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.L308M|MAP2K7_uc010dvv.2_Missense_Mutation_p.L183M	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	308	Protein kinase.				activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	CGTATGGAGCCTGGGCATCTC	0.637												
FBN3	84467	broad.mit.edu	37	19	8176641	8176641	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:8176641G>A	uc002mjf.2	-	31	3996	c.3975C>T	c.(3973-3975)TGC>TGT	p.C1325C		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1325	EGF-like 20; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCTGGGAGACGCATTCATCCA	0.627												
LASS4	79603	broad.mit.edu	37	19	8320601	8320601	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:8320601T>C	uc002mjg.2	+	5	722	c.402T>C	c.(400-402)TGT>TGC	p.C134C	LASS4_uc002mjh.2_Silent_p.C83C|LASS4_uc002mji.2_5'UTR|LASS4_uc010dvz.2_Silent_p.C134C	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4	134	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						AGAAGTTCTGTGAGGCCAGGT	0.667												
HNRNPM	4670	broad.mit.edu	37	19	8533719	8533719	+	Splice_Site	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:8533719G>A	uc010dwe.2	+	9	975	c.895_splice	c.e9+1	p.H299_splice	HNRNPM_uc010dwc.1_Splice_Site_p.H299_splice|HNRNPM_uc010xke.1_Splice_Site_p.H260_splice|HNRNPM_uc010dwd.2_Splice_Site_p.H260_splice|HNRNPM_uc002mka.2_Splice_Site_p.H179_splice	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M						alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						CAACTTCCCCGTAAGTGTTTC	0.408												
MUC16	94025	broad.mit.edu	37	19	9069699	9069699	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:9069699T>C	uc002mkp.2	-	3	17951	c.17747A>G	c.(17746-17748)CAA>CGA	p.Q5916R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5918	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGAGGGCTTTGCCATGACAC	0.493												
ZNF560	147741	broad.mit.edu	37	19	9578164	9578164	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:9578164G>A	uc002mlp.1	-	10	1669	c.1459C>T	c.(1459-1461)CGC>TGC	p.R487C	ZNF560_uc010dwr.1_Missense_Mutation_p.R381C	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						CAATCAAAGCGTTTCTGTCCT	0.403												
COL5A3	50509	broad.mit.edu	37	19	10114729	10114729	+	Silent	SNP	C	C	T	rs140294240	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:10114729C>T	uc002mmq.1	-	5	773	c.687G>A	c.(685-687)CCG>CCA	p.P229P		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	229	Nonhelical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CTGTGGCTGCCGGTGCCAGGT	0.577												
ILF3	3609	broad.mit.edu	37	19	10793819	10793819	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:10793819C>T	uc002mpn.2	+	14	1872	c.1555C>T	c.(1555-1557)CCG>TCG	p.P519S	ILF3_uc002mpm.2_Missense_Mutation_p.P523S|ILF3_uc002mpl.2_Missense_Mutation_p.P519S|ILF3_uc002mpk.2_Missense_Mutation_p.P519S|ILF3_uc010xli.1_Missense_Mutation_p.P117S|ILF3_uc002mpo.2_Missense_Mutation_p.P523S|ILF3_uc002mpp.2_Missense_Mutation_p.P344S|ILF3_uc002mpq.2_5'Flank	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	519					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			ACAGCAGGGGCCGATCCTGAC	0.562												
TMED1	11018	broad.mit.edu	37	19	10943787	10943787	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:10943787A>C	uc002mpy.2	-	4	684	c.568T>G	c.(568-570)TTG>GTG	p.L190V	DNM2_uc002mpx.1_3'UTR	NM_006858	NP_006849	Q13445	TMED1_HUMAN	interleukin 1 receptor-like 1 ligand precursor	190	Extracellular (Potential).				cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			ovary(2)|breast(1)|central_nervous_system(1)	4						ACCCGCTCCAAGTTGCCCTCT	0.627												
ZNF440	126070	broad.mit.edu	37	19	11942182	11942182	+	Splice_Site	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:11942182G>A	uc002msp.1	+	4	348	c.192_splice	c.e4-1	p.R64_splice		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTTTGACAGGAGTCTCATA	0.343												
ZNF709	163051	broad.mit.edu	37	19	12574828	12574828	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:12574828T>A	uc002mtv.3	-	4	2069	c.1908A>T	c.(1906-1908)AGA>AGT	p.R636S	ZNF709_uc002mtw.3_Missense_Mutation_p.R604S|ZNF709_uc002mtx.3_Missense_Mutation_p.R636S	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	636	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACTATGAACTCTTTCATGTA	0.323												
MAST1	22983	broad.mit.edu	37	19	12963047	12963047	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:12963047G>A	uc002mvm.2	+	9	1123	c.995G>A	c.(994-996)CGT>CAT	p.R332H	MAST1_uc002mvk.2_Missense_Mutation_p.R328H	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	332					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						GGCCTCACCCGTGACCCCTTT	0.662												
NFIX	4784	broad.mit.edu	37	19	13192651	13192651	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:13192651G>A	uc010xmx.1	+	8	1313	c.1260G>A	c.(1258-1260)TCG>TCA	p.S420S	NFIX_uc002mwd.2_Silent_p.S412S|NFIX_uc002mwe.2_Silent_p.S404S|NFIX_uc002mwf.2_Silent_p.S374S|NFIX_uc002mwg.1_Silent_p.S411S			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	412					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			CGGATGGCTCGGGCCAGGCCA	0.622											OREG0025286	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
TRMT1	55621	broad.mit.edu	37	19	13223783	13223783	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:13223783G>A	uc002mwj.2	-	5	934	c.684C>T	c.(682-684)GAC>GAT	p.D228D	TRMT1_uc002mwk.2_Silent_p.D228D|TRMT1_uc002mwl.3_Silent_p.D228D|TRMT1_uc010xmz.1_Silent_p.D14D	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	228							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		GATCGATGACGTCAAACCTCT	0.622												
OR1I1	126370	broad.mit.edu	37	19	15198125	15198125	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:15198125G>A	uc010xoe.1	+	1	249	c.249G>A	c.(247-249)GCG>GCA	p.A83A		NM_001004713	NP_001004713	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3						AGATGCTAGCGAACATCCAGG	0.552												
CYP4F12	66002	broad.mit.edu	37	19	15806782	15806782	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:15806782C>T	uc002nbl.2	+	10	1213	c.1152C>T	c.(1150-1152)TGC>TGT	p.C384C		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,									p.C384C(1)		skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					TGACCATGTGCGTGAAGGAGA	0.557												
EPS15L1	58513	broad.mit.edu	37	19	16535966	16535966	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:16535966C>T	uc002ndz.1	-	9	726	c.720G>A	c.(718-720)CCG>CCA	p.P240P	EPS15L1_uc002ndx.2_Silent_p.P240P|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.P130P|EPS15L1_uc010xpf.1_Silent_p.P143P|EPS15L1_uc002nea.1_Silent_p.P240P|EPS15L1_uc010eah.1_Silent_p.P240P|EPS15L1_uc002neb.1_Silent_p.P86P|EPS15L1_uc002nec.1_Silent_p.P240P	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	240					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						TGCCGTGGGACGGCGTGGAGC	0.662												
NWD1	284434	broad.mit.edu	37	19	16918583	16918583	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:16918583G>A	uc002neu.3	+	18	4345	c.3923G>A	c.(3922-3924)AGC>AAC	p.S1308N	NWD1_uc002net.3_Missense_Mutation_p.S1173N|NWD1_uc002nev.3_Missense_Mutation_p.S1102N			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1308							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						ATGTCCCTGAGCAAGTGCGAG	0.612												
FCHO1	23149	broad.mit.edu	37	19	17893892	17893892	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:17893892C>T	uc010ebb.2	+	23	2193	c.2004C>T	c.(2002-2004)AGC>AGT	p.S668S	FCHO1_uc002nhg.3_Silent_p.S668S|FCHO1_uc002nhh.2_Silent_p.S668S|FCHO1_uc010xpw.1_Silent_p.S618S|FCHO1_uc002nhi.2_Silent_p.S124S|FCHO1_uc002nhj.2_Silent_p.S12S	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	668										breast(1)	1						GTGTGTTCAGCGGGACCCCAC	0.592												
LSM4	25804	broad.mit.edu	37	19	18420588	18420588	+	Silent	SNP	G	G	A	rs138296949	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:18420588G>A	uc002niq.2	-	4	399	c.228C>T	c.(226-228)ATC>ATT	p.I76I		NM_012321	NP_036453	Q9Y4Z0	LSM4_HUMAN	U6 snRNA-associated Sm-like protein 4	76					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|mRNA processing|RNA splicing	cytosol|U6 snRNP	protein binding|RNA binding				0						TGACCATGTCGATGATCTCGT	0.677												
TMEM161A	54929	broad.mit.edu	37	19	19240983	19240983	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:19240983C>T	uc002nlg.2	-	6	607	c.577G>A	c.(577-579)GAG>AAG	p.E193K	TMEM161A_uc010eca.2_RNA|TMEM161A_uc002nlh.2_Missense_Mutation_p.E168K|TMEM161A_uc002nli.2_Intron|TMEM161A_uc002nlj.2_Missense_Mutation_p.E68K	NM_017814	NP_060284	Q9NX61	T161A_HUMAN	transmembrane protein 161A precursor	193	Cytoplasmic (Potential).				cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)	2			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			AGGCCCAGCTCGAGGGTCTCC	0.632												
SF4	57794	broad.mit.edu	37	19	19391027	19391027	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:19391027G>A	uc002nmh.2	-	9	1319	c.1317C>T	c.(1315-1317)GAC>GAT	p.D439D	SF4_uc002nmf.2_Translation_Start_Site|SF4_uc002nmg.2_Translation_Start_Site|SF4_uc002nmi.2_Silent_p.D229D|SF4_uc002nmj.2_Silent_p.D229D|SF4_uc002nme.2_Translation_Start_Site	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	439					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						TCTTCTGGGCGTCTGAAAGCT	0.592												
ZNF208	7757	broad.mit.edu	37	19	22154680	22154680	+	Silent	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:22154680A>C	uc002nqp.2	-	6	2921	c.2772T>G	c.(2770-2772)GCT>GCG	p.A924A	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTTTTTCTCCAGCATGAGTTG	0.453												
ZNF676	163223	broad.mit.edu	37	19	22363176	22363176	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:22363176G>C	uc002nqs.1	-	3	1661	c.1343C>G	c.(1342-1344)CCC>CGC	p.P448R		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ACATTTGTAGGGTTTCTCTCC	0.433												
TSHZ3	57616	broad.mit.edu	37	19	31769550	31769550	+	Silent	SNP	C	C	T	rs148943651		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:31769550C>T	uc002nsy.3	-	2	1214	c.1149G>A	c.(1147-1149)TCG>TCA	p.S383S		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	383					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TCAGGATCTGCGACTTCCGGG	0.547												
RHPN2	85415	broad.mit.edu	37	19	33482843	33482843	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:33482843C>T	uc002nuf.2	-	13	1596	c.1530G>A	c.(1528-1530)CGG>CGA	p.R510R	RHPN2_uc010xro.1_Silent_p.R359R|RHPN2_uc002nue.2_Silent_p.R240R	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	510					signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GAGGCGTCCACCGCTTGTTAG	0.532												
PEPD	5184	broad.mit.edu	37	19	33968960	33968960	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:33968960G>A	uc002nur.3	-	7	675	c.540C>T	c.(538-540)ATC>ATT	p.I180I	PEPD_uc010xrr.1_Silent_p.I180I|PEPD_uc010xrs.1_Silent_p.I116I	NM_000285	NP_000276	P12955	PEPD_HUMAN	prolidase isoform 1	180					cellular amino acid metabolic process|collagen catabolic process|proteolysis		aminopeptidase activity|dipeptidase activity|manganese ion binding|metallocarboxypeptidase activity			ovary(2)	2	Esophageal squamous(110;0.137)					ACCACTCAACGATCTCTGGGT	0.512												
GPI	2821	broad.mit.edu	37	19	34890536	34890536	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:34890536G>A	uc002nvg.1	+	16	1577	c.1474G>A	c.(1474-1476)GCC>ACC	p.A492T	GPI_uc002nvf.2_Missense_Mutation_p.A531T|GPI_uc010xrv.1_Missense_Mutation_p.A503T|GPI_uc010xrw.1_Missense_Mutation_p.A464T|GPI_uc010edl.1_Intron|GPI_uc002nvi.1_Missense_Mutation_p.A155T	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	492					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					AGCCTTGGTCGGTGAGTGAGT	0.517												
GRAMD1A	57655	broad.mit.edu	37	19	35514240	35514240	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:35514240G>A	uc010xse.1	+	18	2091	c.1954G>A	c.(1954-1956)GCC>ACC	p.A652T	GRAMD1A_uc002nxk.2_Missense_Mutation_p.A641T|GRAMD1A_uc002nxl.2_Missense_Mutation_p.A414T|GRAMD1A_uc010xsf.1_Missense_Mutation_p.A653T|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Missense_Mutation_p.A263T	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	652						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CCTGGCCCTGGCCAAGGGGTG	0.642												
USF2	7392	broad.mit.edu	37	19	35761384	35761384	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:35761384G>A	uc002nyq.1	+	5	573	c.464G>A	c.(463-465)AGT>AAT	p.S155N	USF2_uc010xss.1_Missense_Mutation_p.S155N|USF2_uc002nyr.1_Missense_Mutation_p.S88N|USF2_uc002nys.1_5'UTR|USF2_uc002nyt.1_Intron|USF2_uc002nyu.1_5'UTR|USF2_uc002nyv.1_5'UTR	NM_003367	NP_003358	Q15853	USF2_HUMAN	upstream stimulatory factor 2 isoform 1	155					lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by glucose	nucleus	bHLH transcription factor binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity				0	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			AATGGTGGCAGTCCGGCGGCC	0.592												
USF2	7392	broad.mit.edu	37	19	35761690	35761690	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:35761690G>A	uc002nyq.1	+	6	759	c.650G>A	c.(649-651)CGG>CAG	p.R217Q	USF2_uc010xss.1_Missense_Mutation_p.R217Q|USF2_uc002nyr.1_Missense_Mutation_p.R150Q|USF2_uc002nys.1_Missense_Mutation_p.R19Q|USF2_uc002nyt.1_Missense_Mutation_p.R86Q|USF2_uc002nyu.1_Missense_Mutation_p.R19Q|USF2_uc002nyv.1_Missense_Mutation_p.R19Q	NM_003367	NP_003358	Q15853	USF2_HUMAN	upstream stimulatory factor 2 isoform 1	217					lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by glucose	nucleus	bHLH transcription factor binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity				0	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			ATCGCCCCCCGGACACACCCT	0.582												
CD22	933	broad.mit.edu	37	19	35828791	35828791	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:35828791C>A	uc010edt.2	+	5	929	c.852C>A	c.(850-852)ACC>ACA	p.T284T	CD22_uc010xst.1_Silent_p.T112T|CD22_uc010edu.2_Silent_p.T284T|CD22_uc010edv.2_Silent_p.T284T|CD22_uc002nzb.3_Intron|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	284	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	AGGATGGGACCTCGCTGAAGA	0.577												
MLL4	9757	broad.mit.edu	37	19	36223276	36223276	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:36223276C>A	uc010eei.2	+	29	5826	c.5826C>A	c.(5824-5826)CCC>CCA	p.P1942P		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1942					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCAGGGTGCCCCCTCCTACCT	0.687												
NFKBID	84807	broad.mit.edu	37	19	36387021	36387021	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:36387021G>A	uc002oci.1	-	9	1041	c.467C>T	c.(466-468)CCG>CTG	p.P156L	NFKBID_uc002och.1_5'UTR|NFKBID_uc002ocj.1_Missense_Mutation_p.P171L	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	156	ANK 4.				inflammatory response	nucleus					0						CGTGTGGAGCGGGGTGAGGCC	0.647												
CLIP3	25999	broad.mit.edu	37	19	36508783	36508783	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:36508783C>T	uc010eeq.1	-	9	1576	c.1294G>A	c.(1294-1296)GTG>ATG	p.V432M	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.V432M	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	432					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TAGAAGCGCACGATCCCCTGC	0.642												
ZNF568	374900	broad.mit.edu	37	19	37441545	37441545	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:37441545C>T	uc002ofc.2	+	7	2005	c.1490C>T	c.(1489-1491)ACG>ATG	p.T497M	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Missense_Mutation_p.T421M|ZNF568_uc010efe.2_Missense_Mutation_p.T421M|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	497					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGAATTCATACGGGTGAGAAA	0.388												
ZNF420	147923	broad.mit.edu	37	19	37618976	37618976	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:37618976A>C	uc002ofl.2	+	5	1298	c.1083A>C	c.(1081-1083)AAA>AAC	p.K361N		NM_144689	NP_653290	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTGGTGAAAAACCCTATAAAT	0.418												
ZNF527	84503	broad.mit.edu	37	19	37879380	37879380	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:37879380G>A	uc010efk.1	+	5	540	c.429G>A	c.(427-429)GCG>GCA	p.A143A	ZNF527_uc002ogf.3_Silent_p.A111A|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGGAAATGCGGAGAGGCATT	0.428												
YIF1B	90522	broad.mit.edu	37	19	38798088	38798088	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:38798088C>T	uc002ohz.2	-	7	818	c.769G>A	c.(769-771)GTA>ATA	p.V257I	YIF1B_uc002ohw.2_Missense_Mutation_p.V226I|YIF1B_uc002ohx.2_Missense_Mutation_p.V242I|YIF1B_uc010xtx.1_Missense_Mutation_p.V240I|YIF1B_uc010xty.1_Missense_Mutation_p.V226I|YIF1B_uc002oia.2_Missense_Mutation_p.V254I|YIF1B_uc002ohy.2_Missense_Mutation_p.V254I|YIF1B_uc002oib.2_Missense_Mutation_p.V254I	NM_001039672	NP_001034761	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B isoform 5	257	Helical; (Potential).					integral to membrane					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AAGATGGCTACGCAGCACCAG	0.622												
PSMD8	5714	broad.mit.edu	37	19	38873894	38873894	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:38873894G>A	uc002oii.3	+	7	969	c.917G>A	c.(916-918)CGA>CAA	p.R306Q		NM_002812	NP_002803	P48556	PSMD8_HUMAN	proteasome 26S non-ATPase subunit 8	306					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome regulatory particle	protein binding			central_nervous_system(1)	1	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TTCCTGCAGCGAGGGTGGGTC	0.567												
RYR1	6261	broad.mit.edu	37	19	39068584	39068584	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:39068584C>T	uc002oit.2	+	98	14329	c.14199C>T	c.(14197-14199)TAC>TAT	p.Y4733Y	RYR1_uc002oiu.2_Silent_p.Y4728Y	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4733					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGGACATCTACGGGCGGGAGC	0.607												
PLEKHG2	64857	broad.mit.edu	37	19	39913533	39913533	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:39913533C>T	uc010xuz.1	+	18	2164	c.1839C>T	c.(1837-1839)CAC>CAT	p.H613H	PLEKHG2_uc010xuy.1_Silent_p.H554H|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Silent_p.H391H	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	613					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCCCACTCCACGTCCTGGAAG	0.577												
PSMC4	5704	broad.mit.edu	37	19	40485741	40485741	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:40485741G>A	uc002omq.2	+	7	728	c.691G>A	c.(691-693)GTG>ATG	p.V231M	PSMC4_uc002omr.2_Missense_Mutation_p.V200M	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	231					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CATCCGGGTCGTGGGCTCGGA	0.552												
AKT2	208	broad.mit.edu	37	19	40747883	40747883	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:40747883C>T	uc002onf.2	-	6	797	c.535G>A	c.(535-537)GCC>ACC	p.A179T	AKT2_uc010egs.2_Missense_Mutation_p.A179T|AKT2_uc010egt.2_Missense_Mutation_p.A117T|AKT2_uc010xvj.1_Missense_Mutation_p.A117T|AKT2_uc010egu.1_Missense_Mutation_p.A117T|AKT2_uc010xvk.1_Missense_Mutation_p.A179T|AKT2_uc002one.2_Missense_Mutation_p.A75T	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	179	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			ATCTTCATGGCGTAGTAGCGG	0.592			A		ovarian|pancreatic 							
C19orf47	126526	broad.mit.edu	37	19	40834366	40834366	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:40834366C>T	uc002oni.3	-	6	505	c.504G>A	c.(502-504)TCG>TCA	p.S168S	C19orf47_uc002ong.2_Silent_p.S27S|C19orf47_uc002onh.2_Silent_p.S101S	NM_178830	NP_849152	Q8N9M1	CS047_HUMAN	hypothetical protein LOC126526	168										ovary(1)|skin(1)	2			Lung(22;0.000636)			ACACAGTGACCGAGATCTTGG	0.607												
LTBP4	8425	broad.mit.edu	37	19	41135394	41135394	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:41135394G>A	uc002ooh.1	+	34	4814	c.4814G>A	c.(4813-4815)CGC>CAC	p.R1605H	LTBP4_uc002oog.1_Missense_Mutation_p.R1568H|LTBP4_uc002ooi.1_Missense_Mutation_p.R1538H|LTBP4_uc002ooj.1_Missense_Mutation_p.R478H|LTBP4_uc002ool.1_Missense_Mutation_p.R617H|LTBP4_uc010xvp.1_Missense_Mutation_p.R365H	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1605	EGF-like 16.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGCATCTGCCGCCCGGGATTC	0.721												
CCDC97	90324	broad.mit.edu	37	19	41822537	41822537	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:41822537C>T	uc002oqg.2	+	2	417	c.295C>T	c.(295-297)CTG>TTG	p.L99L	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	99											0						CCTGGCCCAGCTGTACCACGA	0.637												
ZNF574	64763	broad.mit.edu	37	19	42583781	42583781	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:42583781C>T	uc002osm.3	+	2	1192	c.1023C>T	c.(1021-1023)TGC>TGT	p.C341C	ZNF574_uc002osk.3_Silent_p.C431C	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	341	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				GCCCCCTGTGCAGTCGTGTCT	0.597												
ERF	2077	broad.mit.edu	37	19	42752741	42752741	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:42752741C>A	uc002ote.3	-	4	1681	c.1523G>T	c.(1522-1524)GGT>GTT	p.G508V	ERF_uc002otd.3_Missense_Mutation_p.G239V	NM_006494	NP_006485	P50548	ERF_HUMAN	Ets2 repressor factor	508					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			lung(1)|kidney(1)|central_nervous_system(1)|skin(1)	4		Prostate(69;0.00682)				CTTGTCCTCACCCTCATCCTC	0.682												
PSG5	5673	broad.mit.edu	37	19	43680089	43680089	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:43680089G>T	uc002ovu.2	-	3	773	c.642C>A	c.(640-642)CCC>CCA	p.P214P	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Intron|PSG5_uc002ovx.2_Silent_p.P214P|PSG5_uc002ovv.2_Silent_p.P307P|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	214	Ig-like C2-type 1.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CACATTCATAGGGTCCTGTTT	0.522												
XRCC1	7515	broad.mit.edu	37	19	44048331	44048331	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:44048331C>T	uc002owt.2	-	15	1797	c.1677G>A	c.(1675-1677)CGG>CGA	p.R559R	XRCC1_uc010xwp.1_Silent_p.R528R	NM_006297	NP_006288	P18887	XRCC1_HUMAN	X-ray repair cross complementing protein 1	559	BRCT 2.				base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(2)|large_intestine(1)|prostate(1)|breast(1)	7		Prostate(69;0.0153)				TGAGTTTCCGCCGCTCGTCCC	0.582								Other_BER_factors				
CADM4	199731	broad.mit.edu	37	19	44131398	44131398	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:44131398C>T	uc002oxc.1	-	3	333	c.284G>A	c.(283-285)CGC>CAC	p.R95H		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	95	Ig-like V-type.|Extracellular (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				GTCCTCCAGGCGGGCATCTGA	0.602												
IRGC	56269	broad.mit.edu	37	19	44223276	44223276	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:44223276C>T	uc002oxh.2	+	2	713	c.566C>T	c.(565-567)GCT>GTT	p.A189V		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	189						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				AGAGAGGCCGCTGTCCTGCAG	0.682												
ZNF226	7769	broad.mit.edu	37	19	44676240	44676240	+	Splice_Site	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:44676240G>T	uc002oyp.2	+	4	160	c.16_splice	c.e4-1	p.E6_splice	ZNF226_uc002oyn.2_Splice_Site_p.E6_splice|ZNF226_uc002oyo.2_Splice_Site_p.E6_splice|ZNF226_uc002oyq.2_Splice_Site|ZNF226_uc002oyr.2_Splice_Site|ZNF226_uc010ejg.2_Splice_Site_p.E6_splice|ZNF226_uc002oys.2_Splice_Site_p.E6_splice|ZNF226_uc002oyt.2_Splice_Site_p.E6_splice	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TTTTGTCGTAGGAAGCAGTGA	0.522												
CLPTM1	1209	broad.mit.edu	37	19	45490450	45490450	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:45490450C>T	uc002pai.2	+	8	822	c.807C>T	c.(805-807)GAC>GAT	p.D269D	CLPTM1_uc010ejv.1_Silent_p.D167D|CLPTM1_uc010xxf.1_Silent_p.D167D|CLPTM1_uc010xxg.1_Silent_p.D255D	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	269	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		TGAAGTTCGACGCCGTGAGCG	0.602												
ERCC2	2068	broad.mit.edu	37	19	45855905	45855905	+	Silent	SNP	C	C	T	rs145835916		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:45855905C>T	uc002pbj.2	-	21	1952	c.1905G>A	c.(1903-1905)GCG>GCA	p.A635A	ERCC2_uc002pbh.2_Silent_p.A198A|ERCC2_uc002pbi.2_Silent_p.A328A|ERCC2_uc010ejz.2_Silent_p.A557A|ERCC2_uc002pbk.2_Silent_p.A611A	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	635	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		ATTCCAGCCGCGCCTGCAGAT	0.597			Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum			
FOXA3	3171	broad.mit.edu	37	19	46376101	46376101	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:46376101A>G	uc002pdr.2	+	2	1035	c.838A>G	c.(838-840)ACA>GCA	p.T280A		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	280					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		CGCTTCCTCCACACCCTATTT	0.632												
IGFL4	444882	broad.mit.edu	37	19	46543646	46543646	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:46543646C>T	uc002pdy.1	-	3	153	c.99G>A	c.(97-99)GCG>GCA	p.A33A		NM_001002923	NP_001002923	Q6B9Z1	IGFL4_HUMAN	IGF-like family member 4 precursor	33						extracellular region					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		CGCACCTGGGCGCTGGCTGGC	0.602												
PPP5C	5536	broad.mit.edu	37	19	46857048	46857048	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:46857048C>T	uc002pem.2	+	2	225	c.165C>T	c.(163-165)ATC>ATT	p.I55I	PPP5C_uc010xya.1_5'UTR|PPP5C_uc002pen.2_Silent_p.I55I	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	55	TPR 1.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		GCCAGGCCATCGAGCTGAACC	0.617												
PNMAL1	55228	broad.mit.edu	37	19	46973945	46973945	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:46973945G>A	uc002peq.3	-	2	654	c.348C>T	c.(346-348)GCC>GCT	p.A116A	PNMAL1_uc002per.3_Silent_p.A116A	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	116											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		tgcgcccctcggcatccagga	0												
GRLF1	2909	broad.mit.edu	37	19	47422067	47422067	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:47422067G>A	uc010ekv.2	+	1	135	c.135G>A	c.(133-135)CCG>CCA	p.P45P		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	45					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		TCGTGCGCCCGAGTGCTGACG	0.532												
PLEKHA4	57664	broad.mit.edu	37	19	49362226	49362226	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:49362226C>T	uc002pkx.2	-	8	1414	c.863G>A	c.(862-864)CGC>CAC	p.R288H	PLEKHA4_uc002pkw.1_Intron|PLEKHA4_uc010eml.2_Missense_Mutation_p.R288H	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	288	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GAGGGTCTGGCGTTGGGGGCC	0.692												
PLEKHA4	57664	broad.mit.edu	37	19	49368837	49368837	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:49368837C>T	uc002pkx.2	-	3	666	c.115G>A	c.(115-117)GCC>ACC	p.A39T	PLEKHA4_uc010eml.2_Missense_Mutation_p.A39T	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	39						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		TTCCCAAAGGCGTGGATCTTG	0.587												
RUVBL2	10856	broad.mit.edu	37	19	49510397	49510397	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:49510397C>T	uc002plr.1	+	5	401	c.388C>T	c.(388-390)CGC>TGC	p.R130C	RUVBL2_uc002plq.1_Missense_Mutation_p.R85C|RUVBL2_uc010yab.1_Missense_Mutation_p.R130C|RUVBL2_uc002pls.1_RNA|RUVBL2_uc010emn.1_Missense_Mutation_p.R85C|RUVBL2_uc010yac.1_Missense_Mutation_p.R85C	NM_006666	NP_006657	Q9Y230	RUVB2_HUMAN	RuvB-like 2	130					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		CATCGGCGTTCGCATCAAGTA	0.657												
KCNA7	3743	broad.mit.edu	37	19	49573446	49573446	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:49573446A>G	uc002pmg.2	-	2	1601	c.1245T>C	c.(1243-1245)CAT>CAC	p.H415H		NM_031886	NP_114092	Q96RP8	KCNA7_HUMAN	potassium voltage-gated channel, shaker-related	415						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)	1		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000397)|OV - Ovarian serous cystadenocarcinoma(262;0.000519)|GBM - Glioblastoma multiforme(486;0.00541)|Epithelial(262;0.0441)		GCATGTCCACATGGCTGAACA	0.602												
PRMT1	3276	broad.mit.edu	37	19	50189896	50189896	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:50189896G>A	uc010enf.1	+	10	987	c.945G>A	c.(943-945)ACG>ACA	p.T315T	PRMT1_uc002ppc.1_RNA|PRMT1_uc002ppd.2_Silent_p.T291T|PRMT1_uc002ppe.2_Silent_p.T297T|PRMT1_uc002ppf.2_RNA|PRMT1_uc002ppg.2_Silent_p.T262T|PRMT1_uc010ybb.1_5'Flank|C19orf76_uc002pph.2_5'Flank	NM_001536	NP_001527	Q8WUW5	Q8WUW5_HUMAN	HMT1 hnRNP methyltransferase-like 2 isoform 1	296						cytoplasm	protein methyltransferase activity			ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00103)|GBM - Glioblastoma multiforme(134;0.012)		GGAAGCAGACGGTGTTCTACA	0.687												
ZNF473	25888	broad.mit.edu	37	19	50542512	50542512	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:50542512C>T	uc002prn.2	+	3	341	c.104C>T	c.(103-105)GCG>GTG	p.A35V	ZNF473_uc002prm.2_Missense_Mutation_p.A35V|ZNF473_uc010ybo.1_Missense_Mutation_p.A23V	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	35	KRAB.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		TGGGACACAGCGTTGGACAAT	0.582												
ZNF473	25888	broad.mit.edu	37	19	50545072	50545072	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:50545072C>T	uc002prn.2	+	4	459	c.222C>T	c.(220-222)AGC>AGT	p.S74S	ZNF473_uc002prm.2_Silent_p.S74S|ZNF473_uc010ybo.1_Silent_p.S62S	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	74	KRAB.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		AAGCAACAAGCCCTGGTGAGT	0.587												
GPR32	2854	broad.mit.edu	37	19	51274765	51274765	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:51274765C>T	uc010ycf.1	+	1	908	c.908C>T	c.(907-909)GCC>GTC	p.A303V		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	303	Helical; Name=7; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCTAGCTTTGCCTTGGGCTGT	0.542												
ZNF761	388561	broad.mit.edu	37	19	53950474	53950474	+	Translation_Start_Site	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:53950474C>T	uc010eqp.2	+	4	411	c.-47C>T	c.(-49--45)TACGT>TATGT		ZNF761_uc002qbr.2_RNA|ZNF761_uc010ydy.1_Translation_Start_Site|ZNF761_uc002qbs.2_RNA|ZNF761_uc002qbt.1_5'Flank	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ACTCTTGGTACGTGAGGAAGA	0.433												
MBOAT7	79143	broad.mit.edu	37	19	54682578	54682578	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:54682578C>T	uc002qdq.2	-	8	1201	c.935G>A	c.(934-936)CGG>CAG	p.R312Q	MBOAT7_uc010erg.2_5'UTR|MBOAT7_uc010yem.1_Missense_Mutation_p.R294Q|MBOAT7_uc002qdr.2_Missense_Mutation_p.R312Q|MBOAT7_uc002qds.2_Missense_Mutation_p.R239Q|MBOAT7_uc010yen.1_Missense_Mutation_p.R239Q|MBOAT7_uc002qdt.3_Missense_Mutation_p.R312Q	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	312					phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ATCGCGCACCCGCACGCAGAA	0.587												
LILRB3	11025	broad.mit.edu	37	19	54720983	54720983	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:54720983G>A	uc002qef.1	-	13	1986	c.1875C>T	c.(1873-1875)TAC>TAT	p.Y625Y	LILRB3_uc002qee.1_Silent_p.Y626Y|LILRB3_uc002qeh.1_Silent_p.Y625Y|LILRB3_uc002qeg.1_RNA|LILRB3_uc002qei.1_Silent_p.Y625Y|LILRA6_uc002qek.1_Silent_p.Y626Y|LILRB3_uc010erh.1_Silent_p.Y642Y|LILRB3_uc002qej.1_RNA|LILRA6_uc002qel.1_Silent_p.Y625Y|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.Y626Y|LILRB3_uc002qep.1_Silent_p.Y626Y|LILRB3_uc002qeq.1_Silent_p.Y625Y|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Silent_p.Y626Y	NM_006864	NP_006855	O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor,	625	ITIM motif 3.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			skin(2)|ovary(1)	3	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCAGAGTGGCGTAGATGCTGG	0.627												
NCR1	9437	broad.mit.edu	37	19	55420752	55420752	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:55420752C>T	uc002qib.2	+	4	542	c.504C>T	c.(502-504)TAC>TAT	p.Y168Y	NCR1_uc002qic.2_Silent_p.Y168Y|NCR1_uc002qie.2_Silent_p.Y168Y|NCR1_uc002qid.2_Silent_p.Y73Y|NCR1_uc002qif.2_Silent_p.Y73Y|NCR1_uc010esj.2_Silent_p.Y61Y	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	168	Extracellular (Potential).|Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		AGCGCGGATACGGGAAGGTCC	0.567												
NLRP2	55655	broad.mit.edu	37	19	55494974	55494974	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:55494974C>T	uc002qij.2	+	6	1994	c.1908C>T	c.(1906-1908)GAC>GAT	p.D636D	NLRP2_uc010yfp.1_Silent_p.D613D|NLRP2_uc010esn.2_Silent_p.D612D|NLRP2_uc010eso.2_Silent_p.D633D|NLRP2_uc010esp.2_Silent_p.D614D	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	636					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ATGCAGTAGACGTTGTGCCAT	0.498												
NLRP9	338321	broad.mit.edu	37	19	56243922	56243922	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:56243922G>A	uc002qly.2	-	2	1303	c.1275C>T	c.(1273-1275)GGC>GGT	p.G425G		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	425	NACHT.		G -> D (in a breast cancer sample; somatic mutation).			cytoplasm	ATP binding	p.G425D(1)		skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CCCACATCACGCCCTCAGACT	0.473												
PEG3	5178	broad.mit.edu	37	19	57333110	57333110	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:57333110C>T	uc002qnu.2	-	4	929	c.578G>A	c.(577-579)CGG>CAG	p.R193Q	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.R68Q|ZIM2_uc002qnq.2_Missense_Mutation_p.R68Q|ZIM2_uc010etp.2_Missense_Mutation_p.R68Q|ZIM2_uc010ygs.1_Missense_Mutation_p.R68Q|PEG3_uc002qnt.2_Missense_Mutation_p.R194Q|PEG3_uc002qnv.2_Missense_Mutation_p.R193Q|PEG3_uc002qnw.2_Missense_Mutation_p.R68Q|PEG3_uc002qnx.2_Missense_Mutation_p.R67Q|PEG3_uc010etr.2_Missense_Mutation_p.R193Q	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	193					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R193W(1)		ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GGAAAGATCCCGCGGAGGCAT	0.542												
ZNF543	125919	broad.mit.edu	37	19	57839932	57839932	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:57839932G>A	uc002qoi.1	+	4	1447	c.1102G>A	c.(1102-1104)GAA>AAA	p.E368K		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	368	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAAACCCTTTGAATGCAACGA	0.507												
ZNF17	7565	broad.mit.edu	37	19	57931842	57931842	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:57931842C>T	uc002qoo.1	+	3	1213	c.982C>T	c.(982-984)CGG>TGG	p.R328W	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Missense_Mutation_p.R330W	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		TACTGGAGAACGGCCTTATGG	0.443												
ZNF549	256051	broad.mit.edu	37	19	58048866	58048866	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:58048866G>T	uc002qpb.1	+	4	743	c.494G>T	c.(493-495)AGC>ATC	p.S165I	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Missense_Mutation_p.S152I	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAGGAGGAGAGCAGTGCCTTG	0.463												
ZNF416	55659	broad.mit.edu	37	19	58083691	58083691	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:58083691G>A	uc002qpf.2	-	4	1752	c.1581C>T	c.(1579-1581)TGC>TGT	p.C527C	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	527	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		AGGATTTCCCGCACTGTCCAC	0.438												
SLC27A5	10998	broad.mit.edu	37	19	59011792	59011792	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:59011792A>G	uc002qtc.2	-	6	1492	c.1382T>C	c.(1381-1383)CTG>CCG	p.L461P	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	461	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		AAAGGGGGACAGCATCTGGGG	0.622												
TPO	7173	broad.mit.edu	37	2	1459959	1459959	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:1459959G>A	uc002qww.2	+	7	815	c.724G>A	c.(724-726)GCG>ACG	p.A242T	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.A242T|TPO_uc002qwr.2_Missense_Mutation_p.A242T|TPO_uc002qwx.2_Missense_Mutation_p.A242T|TPO_uc010yio.1_Missense_Mutation_p.A242T|TPO_uc010yip.1_Missense_Mutation_p.A242T	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	242	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity	p.A242A(1)		ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCACGACATCGCGTTCACACC	0.498												
MBOAT2	129642	broad.mit.edu	37	2	9017344	9017344	+	Splice_Site	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:9017344C>A	uc002qzg.1	-	7	640	c.507_splice	c.e7-1	p.R169_splice	MBOAT2_uc010yix.1_Splice_Site_p.R169_splice	NM_138799	NP_620154	Q6ZWT7	MBOA2_HUMAN	O-acyltransferase (membrane bound) domain						phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGGCATGCGCCTGCAATGAAA	0.428												
HPCAL1	3241	broad.mit.edu	37	2	10560003	10560003	+	Silent	SNP	C	C	T	rs143370055	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:10560003C>T	uc002raj.2	+	3	494	c.120C>T	c.(118-120)ACC>ACT	p.T40T	HPCAL1_uc002rak.2_Silent_p.T40T|HPCAL1_uc002ral.2_Silent_p.T40T|HPCAL1_uc010exe.2_RNA|HPCAL1_uc010exf.2_Silent_p.T40T	NM_002149	NP_002140	P37235	HPCL1_HUMAN	hippocalcin-like 1	40	EF-hand 1.						calcium ion binding			pancreas(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		ACTGCCCCACCGGCCACCTGA	0.622												
GREB1	9687	broad.mit.edu	37	2	11756801	11756801	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:11756801C>T	uc002rbk.1	+	21	3667	c.3367C>T	c.(3367-3369)CGC>TGC	p.R1123C	GREB1_uc002rbp.1_Missense_Mutation_p.R121C	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1123	Ser-rich.					integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GGAGAGGTCCCGCTCCCACGA	0.493												
KCNS3	3790	broad.mit.edu	37	2	18112315	18112315	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:18112315G>A	uc002rcv.2	+	3	491	c.40G>A	c.(40-42)GAG>AAG	p.E14K	KCNS3_uc002rcw.2_Missense_Mutation_p.E14K	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	14	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TGGACAAGACGAGGAACTTGT	0.537												
SDC1	6382	broad.mit.edu	37	2	20402951	20402951	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:20402951C>T	uc002rdo.1	-	4	959	c.660G>A	c.(658-660)ACG>ACA	p.T220T	SDC1_uc002rdp.1_Silent_p.T220T|SDC1_uc010exv.2_Intron	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	220	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCACTACAGCCGTATTCTCCC	0.647												
KIF3C	3797	broad.mit.edu	37	2	26203351	26203351	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:26203351C>T	uc002rgu.2	-	1	2093	c.1436G>A	c.(1435-1437)CGC>CAC	p.R479H	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.R479H	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	479	Potential.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCAGGCTGCGGTCATCCTG	0.607												
EPT1	85465	broad.mit.edu	37	2	26606214	26606214	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:26606214A>G	uc010ykz.1	+	7	877	c.730A>G	c.(730-732)AGA>GGA	p.R244G	EPT1_uc010eyl.1_RNA	NM_033505	NP_277040	Q9C0D9	EPT1_HUMAN	selenoprotein I	244					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding				0						AAACTTTTTCAGGTAAGTATT	0.289												
OTOF	9381	broad.mit.edu	37	2	26693574	26693574	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:26693574C>T	uc002rhk.2	-	32	4037	c.3910G>A	c.(3910-3912)GAG>AAG	p.E1304K	OTOF_uc010yla.1_Missense_Mutation_p.E34K|OTOF_uc002rhh.2_Missense_Mutation_p.E537K|OTOF_uc002rhi.2_Missense_Mutation_p.E614K|OTOF_uc002rhj.2_Missense_Mutation_p.E537K	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1304	Cytoplasmic (Potential).|Poly-Lys.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ttcttcttctccttctcctcc	0.512												
KCNK3	3777	broad.mit.edu	37	2	26950703	26950703	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:26950703G>A	uc002rhn.2	+	2	615	c.452G>A	c.(451-453)CGC>CAC	p.R151H		NM_002246	NP_002237	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	151	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCATGCGGCGCGCCGACGTG	0.647												
DPYSL5	56896	broad.mit.edu	37	2	27150265	27150265	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:27150265C>T	uc002rhu.3	+	4	723	c.565C>T	c.(565-567)CGC>TGC	p.R189C	DPYSL5_uc002rhv.3_Missense_Mutation_p.R189C	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	189					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCAATCGCCCGCGTCCATGC	0.532												
AGBL5	60509	broad.mit.edu	37	2	27278613	27278613	+	Silent	SNP	G	G	A	rs140050281		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:27278613G>A	uc002rie.2	+	7	1189	c.972G>A	c.(970-972)CCG>CCA	p.P324P	AGBL5_uc002ric.2_Silent_p.P324P|AGBL5_uc002rid.2_Silent_p.P324P|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	324					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTGCACCCGGCCATCTATG	0.552												
AGBL5	60509	broad.mit.edu	37	2	27282079	27282079	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:27282079C>T	uc002rie.2	+	11	2113	c.1896C>T	c.(1894-1896)TCC>TCT	p.S632S	AGBL5_uc002rid.2_Silent_p.S632S|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	632					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCCTGCTCCGAAAACACCT	0.537												
IFT172	26160	broad.mit.edu	37	2	27679392	27679392	+	Silent	SNP	G	G	A	rs76787560	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:27679392G>A	uc002rku.2	-	30	3408	c.3357C>T	c.(3355-3357)CAC>CAT	p.H1119H	IFT172_uc010ezb.2_5'Flank	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	1119					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TGTCTGCAGCGTGGTCAACAG	0.522												
PLB1	151056	broad.mit.edu	37	2	28825712	28825712	+	Missense_Mutation	SNP	G	G	A	rs142314104	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:28825712G>A	uc002rmb.1	+	39	2698	c.2698G>A	c.(2698-2700)GTG>ATG	p.V900M	PLB1_uc010ezj.1_Missense_Mutation_p.V889M|PLB1_uc002rme.1_Translation_Start_Site|PLB1_uc002rmf.1_5'Flank	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	900	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|3.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					GGTCAACCTCGTGGACTTCCT	0.612												
C2orf71	388939	broad.mit.edu	37	2	29295029	29295029	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:29295029C>A	uc002rmt.1	-	1	2099	c.2099G>T	c.(2098-2100)GGG>GTG	p.G700V		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	700					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						TGGAAGCTTCCCAGCTTTGCC	0.517												
TMEM178	130733	broad.mit.edu	37	2	39931305	39931305	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:39931305C>T	uc002rrt.2	+	2	510	c.485C>T	c.(484-486)ACC>ATC	p.T162I	TMEM178_uc010fam.1_Missense_Mutation_p.T162I	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	162	Extracellular (Potential).					integral to membrane					0		all_hematologic(82;0.248)				TTAACCAAGACCATACAGCAA	0.458												
ABCG8	64241	broad.mit.edu	37	2	44079930	44079930	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:44079930C>T	uc002rtq.2	+	6	977	c.887C>T	c.(886-888)GCG>GTG	p.A296V	ABCG8_uc010yoa.1_Missense_Mutation_p.A296V	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	296	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TACTTAGGGGCGGCCCAGCAC	0.592												
SRBD1	55133	broad.mit.edu	37	2	45778340	45778340	+	Silent	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:45778340A>C	uc002rus.2	-	12	1675	c.1599T>G	c.(1597-1599)CCT>CCG	p.P533P	SRBD1_uc010yoc.1_Silent_p.P52P	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	533					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			GCCCTGGAACAGGGCTTGTTA	0.398												
SRBD1	55133	broad.mit.edu	37	2	45800478	45800478	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:45800478G>A	uc002rus.2	-	9	1249	c.1173C>T	c.(1171-1173)TGC>TGT	p.C391C		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	391					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			GTCTCTTCTGGCACCTGTTCA	0.328												
FSHR	2492	broad.mit.edu	37	2	49210115	49210115	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:49210115C>T	uc002rww.2	-	8	678	c.604G>A	c.(604-606)GAT>AAT	p.D202N	FSHR_uc002rwx.2_Missense_Mutation_p.D202N|FSHR_uc010fbn.2_Missense_Mutation_p.D176N	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	202	LRR 7.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TTATTATTATCGCTTAGATTC	0.413									Gonadal_Dysgenesis_46_XX			
NRXN1	9378	broad.mit.edu	37	2	50318469	50318469	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:50318469T>C	uc010fbp.2	-	3	1412	c.605A>G	c.(604-606)TAC>TGC	p.Y202C	NRXN1_uc002rxb.3_Missense_Mutation_p.Y909C|NRXN1_uc010fbq.2_Missense_Mutation_p.Y1277C|NRXN1_uc002rxe.3_Missense_Mutation_p.Y1237C	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	202	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACCTGCAGGGTAGCGCTCGAT	0.448												
NRXN1	9378	broad.mit.edu	37	2	50573961	50573961	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:50573961C>T	uc010fbp.2	-	1	934	c.127G>A	c.(127-129)GGC>AGC	p.G43S	NRXN1_uc002rxb.3_Intron|NRXN1_uc010fbq.2_Intron|NRXN1_uc002rxe.3_Intron|NRXN1_uc002rxc.1_Intron	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	43					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCTAGGAGGCCGCTGAGGGTG	0.522												
USP34	9736	broad.mit.edu	37	2	61441428	61441428	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:61441428G>A	uc002sbe.2	-	68	8471	c.8449C>T	c.(8449-8451)CGC>TGC	p.R2817C		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	2817					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			ACAATAAGGCGGATATTCTCT	0.428												
B3GNT2	10678	broad.mit.edu	37	2	62450427	62450427	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:62450427A>G	uc002sbs.2	+	2	1310	c.1072A>G	c.(1072-1074)ATC>GTC	p.I358V		NM_006577	NP_006568	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal	358	Lumenal (Potential).					Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			GACATTTGATATCGAGGAGAA	0.408												
ANTXR1	84168	broad.mit.edu	37	2	69409628	69409628	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:69409628C>T	uc002sfg.2	+	16	1545	c.1189C>T	c.(1189-1191)CGT>TGT	p.R397C		NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	397	Cytoplasmic (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						ATTTTAGGTTCGTTGGGGAGA	0.413									Familial_Infantile_Hemangioma			
ANXA4	307	broad.mit.edu	37	2	70039823	70039823	+	Silent	SNP	C	C	T	rs141776547		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:70039823C>T	uc002sfr.3	+	8	743	c.516C>T	c.(514-516)CTC>CTT	p.L172L	ANXA4_uc010yqn.1_RNA|ANXA4_uc002sfs.3_Silent_p.L150L|ANXA4_uc010yqo.1_Silent_p.L88L	NM_001153	NP_001144	P09525	ANXA4_HUMAN	annexin IV	170					anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity				0						ACGATGCTCTCGTGAGACAGG	0.453												
CLEC4F	165530	broad.mit.edu	37	2	71043196	71043196	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:71043196C>A	uc002shf.2	-	4	1394	c.1317G>T	c.(1315-1317)CAG>CAT	p.Q439H	CLEC4F_uc010yqv.1_Missense_Mutation_p.Q439H	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	439	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						TCTGCTCCTGCTGGATTTCCA	0.517												
VAX2	25806	broad.mit.edu	37	2	71148370	71148370	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:71148370C>T	uc002shh.2	+	2	422	c.390C>T	c.(388-390)CGC>CGT	p.R130R		NM_012476	NP_036608	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	130	Homeobox.				ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TGGTGGGCCGCGAGCGCACTG	0.647												
ZNF638	27332	broad.mit.edu	37	2	71591248	71591248	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:71591248G>A	uc002shx.2	+	5	1902	c.1583G>A	c.(1582-1584)CGT>CAT	p.R528H	ZNF638_uc010fec.2_Missense_Mutation_p.R634H|ZNF638_uc010yqw.1_Missense_Mutation_p.R107H|ZNF638_uc002shw.2_Missense_Mutation_p.R528H|ZNF638_uc002shy.2_Missense_Mutation_p.R528H|ZNF638_uc002shz.2_Missense_Mutation_p.R528H|ZNF638_uc002sia.2_Missense_Mutation_p.R528H|ZNF638_uc002sib.1_Missense_Mutation_p.R528H|ZNF638_uc010fed.2_5'Flank	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	528	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ATTTGCCATCGTTTCATTTCT	0.433												
LRRTM1	347730	broad.mit.edu	37	2	80529936	80529936	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:80529936C>T	uc002sok.1	-	2	1279	c.1009G>A	c.(1009-1011)GAT>AAT	p.D337N	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	337	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						AAGTTGCCATCGTAGCGCCCC	0.657										HNSCC(69;0.2)		
PTCD3	55037	broad.mit.edu	37	2	86355071	86355071	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:86355071G>A	uc002sqw.2	+	14	1170	c.1104G>A	c.(1102-1104)TCG>TCA	p.S368S	PTCD3_uc002sqx.1_5'UTR	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	368	PPR 6.					mitochondrion	protein binding			ovary(1)	1						GAGAACCCTCGCTTGCAACAT	0.338												
ZAP70	7535	broad.mit.edu	37	2	98351851	98351851	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:98351851C>T	uc002syd.1	+	10	1428	c.1221C>T	c.(1219-1221)GCC>GCT	p.A407A	ZAP70_uc010yvf.1_3'UTR|ZAP70_uc002sye.1_Silent_p.A297A|ZAP70_uc002syf.1_Silent_p.A100A	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	407	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						TCTGCCAGGCCGAGGCCCTCA	0.662												
CNGA3	1261	broad.mit.edu	37	2	99008387	99008387	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:99008387G>A	uc002syt.2	+	7	1044	c.627G>A	c.(625-627)TCG>TCA	p.S209S	CNGA3_uc002syu.2_Silent_p.S191S|CNGA3_uc010fij.2_Silent_p.S213S	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	209					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						TGGACTACTCGGCAGATGTCC	0.597												
LIPT1	51601	broad.mit.edu	37	2	99779031	99779031	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:99779031C>T	uc002szm.3	+	4	951	c.611C>T	c.(610-612)GCC>GTC	p.A204V	MRPL30_uc002szl.1_Intron|LIPT1_uc002szn.3_Missense_Mutation_p.A204V|LIPT1_uc002szo.3_Missense_Mutation_p.A204V|LIPT1_uc002szp.3_Missense_Mutation_p.A204V|LIPT1_uc002szq.3_Missense_Mutation_p.A204V|MRPL30_uc002szr.2_Intron	NM_145198	NP_660199	Q9Y234	LIPT_HUMAN	lipoyltransferase 1 precursor	204					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity				0					Lipoic Acid(DB00166)	AGGAGCAATGCCACTGCTAGC	0.438												
EIF5B	9669	broad.mit.edu	37	2	100013282	100013282	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:100013282G>A	uc002tab.2	+	22	3498	c.3314G>A	c.(3313-3315)CGA>CAA	p.R1105Q	EIF5B_uc010yvq.1_Missense_Mutation_p.R87Q	NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	1105					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TTTAATTCTCGAGATCCGATA	0.413												
PDCL3	79031	broad.mit.edu	37	2	101188062	101188062	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:101188062T>C	uc002tao.2	+	5	491	c.379T>C	c.(379-381)TGT>CGT	p.C127R		NM_024065	NP_076970	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	127					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding				0						AATTCCCCTCTGTGCCCTGAT	0.388												
STEAP3	55240	broad.mit.edu	37	2	120020821	120020821	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:120020821C>T	uc002tlp.2	+	6	1531	c.1374C>T	c.(1372-1374)CTC>CTT	p.L458L	STEAP3_uc002tlq.2_Silent_p.L468L|STEAP3_uc002tlr.2_Silent_p.L458L|STEAP3_uc010fle.2_3'UTR	NM_018234	NP_060704	Q658P3	STEA3_HUMAN	dudulin 2 isoform b	458	Cytoplasmic (Potential).				apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			central_nervous_system(2)|skin(1)	3						GCCGCAGACTCGCCAGGATCC	0.632												
INHBB	3625	broad.mit.edu	37	2	121107076	121107076	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:121107076G>A	uc002tmn.2	+	2	896	c.850G>A	c.(850-852)GAC>AAC	p.D284N		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	284					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)				TCGGCTGGGCGACAGCAGGCA	0.647												
IWS1	55677	broad.mit.edu	37	2	128281353	128281353	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:128281353T>C	uc002ton.2	-	2	352	c.49A>G	c.(49-51)ACC>GCC	p.T17A	IWS1_uc010yzl.1_RNA|IWS1_uc010fma.2_Intron	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	17					transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TGTACTGGGGTAGCACCACCA	0.418												
TUBA3E	112714	broad.mit.edu	37	2	130951399	130951399	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:130951399C>T	uc002tqv.2	-	4	1117	c.1016G>A	c.(1015-1017)CGC>CAC	p.R339H		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	339					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					CTGGATAGTGCGCTTGGTCTT	0.547												
IMP4	92856	broad.mit.edu	37	2	131103825	131103825	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:131103825C>T	uc002tra.1	+	8	758	c.741C>T	c.(739-741)GTC>GTT	p.V247V		NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	247	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					TCACTGAGGTCGGGCCCCGCT	0.622												
THSD7B	80731	broad.mit.edu	37	2	137852592	137852592	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:137852592A>T	uc002tva.1	+	3	1007	c.1007A>T	c.(1006-1008)AAC>ATC	p.N336I	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.N226I	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGGAGCCGGAACGTGAAGCAC	0.542												
SPOPL	339745	broad.mit.edu	37	2	139326628	139326628	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:139326628G>A	uc002tvh.2	+	11	1557	c.1157G>A	c.(1156-1158)CGC>CAC	p.R386H		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	386						nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GGCATTCCACGCAAACGGCTA	0.443												
GTDC1	79712	broad.mit.edu	37	2	144710386	144710386	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:144710386A>C	uc002tvp.2	-	10	1434	c.1155T>G	c.(1153-1155)TGT>TGG	p.C385W	GTDC1_uc002tvo.2_Missense_Mutation_p.V337G|GTDC1_uc002tvq.2_Missense_Mutation_p.C267W|GTDC1_uc002tvr.2_Missense_Mutation_p.C300W|GTDC1_uc010fnn.2_Missense_Mutation_p.C385W|GTDC1_uc002tvs.2_Missense_Mutation_p.C353W|GTDC1_uc010fno.2_Missense_Mutation_p.C256W	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	385					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)		AAAGTGGGTAACACCCACAGT	0.333												
ACVR2A	92	broad.mit.edu	37	2	148674946	148674946	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:148674946G>A	uc002twg.2	+	7	1036	c.767G>A	c.(766-768)GGC>GAC	p.G256D	ACVR2A_uc010zbn.1_Missense_Mutation_p.G148D|ACVR2A_uc002twh.2_Missense_Mutation_p.G256D	NM_001616	NP_001607	P27037	AVR2A_HUMAN	activin A receptor, type IIA precursor	256	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of erythrocyte differentiation|positive regulation of osteoblast differentiation|positive regulation of protein phosphorylation	cytoplasm|inhibin-betaglycan-ActRII complex|integral to plasma membrane	ATP binding|coreceptor activity|inhibin beta-A binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			stomach(8)|large_intestine(2)|lung(1)|breast(1)|kidney(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0969)		GAAAAACGAGGCACCAGTGTT	0.403												
NEB	4703	broad.mit.edu	37	2	152521924	152521924	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:152521924C>T	uc010fnx.2	-	42	5352	c.5161G>A	c.(5161-5163)GAG>AAG	p.E1721K		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1721	Nebulin 44.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCAGCTTCTCGGGGTGCTGG	0.507												
FAP	2191	broad.mit.edu	37	2	163072486	163072486	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:163072486C>T	uc002ucd.2	-	10	996	c.788G>A	c.(787-789)CGG>CAG	p.R263Q	FAP_uc010zct.1_Missense_Mutation_p.R238Q|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Missense_Mutation_p.R230Q	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	263	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						AATAAATATCCGAACAACGGG	0.403												
LRP2	4036	broad.mit.edu	37	2	170099985	170099985	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:170099985G>A	uc002ues.2	-	23	3691	c.3478C>T	c.(3478-3480)CGA>TGA	p.R1160*	LRP2_uc010zdf.1_Nonsense_Mutation_p.R1023*	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1160	LDL-receptor class A 11.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCAATACATCGATGATTGGGG	0.398												
METTL8	79828	broad.mit.edu	37	2	172188335	172188335	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:172188335A>G	uc010zdo.1	-	6	840	c.699T>C	c.(697-699)TCT>TCC	p.S233S	METTL8_uc002ugu.3_Silent_p.S233S|METTL8_uc002ugv.3_Silent_p.S233S|METTL8_uc002ugt.3_Silent_p.S233S|METTL8_uc002ugs.3_Silent_p.S183S|METTL8_uc010zdp.1_Silent_p.S188S	NM_024770	NP_079046	B3KW44	B3KW44_HUMAN	methyltransferase like 8	233							methyltransferase activity			ovary(1)	1						CCACAGCTCCAGAAGCAAAAT	0.323												
HOXD4	3233	broad.mit.edu	37	2	177017383	177017383	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:177017383T>C	uc002uks.2	+	2	730	c.481T>C	c.(481-483)TAC>CAC	p.Y161H		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	161	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		CCGAACGGCCTACACCCGGCA	0.552												
TTN	7273	broad.mit.edu	37	2	179397385	179397385	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:179397385G>A	uc010zfg.1	-	307	96477	c.96253C>T	c.(96253-96255)CGT>TGT	p.R32085C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R25780C|TTN_uc010zfi.1_Missense_Mutation_p.R25713C|TTN_uc010zfj.1_Missense_Mutation_p.R25588C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33012							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCAAGAGAACGTCTTCTAGGT	0.463												
TTN	7273	broad.mit.edu	37	2	179435651	179435651	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:179435651C>A	uc010zfg.1	-	275	67728	c.67504G>T	c.(67504-67506)GGC>TGC	p.G22502C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16197C|TTN_uc010zfi.1_Missense_Mutation_p.G16130C|TTN_uc010zfj.1_Missense_Mutation_p.G16005C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23429							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAACTAGGCCAGTTACTTCA	0.418												
TTN	7273	broad.mit.edu	37	2	179499546	179499546	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:179499546G>A	uc010zfg.1	-	178	34575	c.34351C>T	c.(34351-34353)CGC>TGC	p.R11451C	TTN_uc010zfh.1_Missense_Mutation_p.R5146C|TTN_uc010zfi.1_Missense_Mutation_p.R5079C|TTN_uc010zfj.1_Missense_Mutation_p.R4954C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12378							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTAAGAAGCGTTTTCCACCT	0.373												
NCKAP1	10787	broad.mit.edu	37	2	183867725	183867725	+	Missense_Mutation	SNP	C	C	T	rs142669044	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:183867725C>T	uc002upc.2	-	4	748	c.346G>A	c.(346-348)GTT>ATT	p.V116I	NCKAP1_uc002upb.2_Missense_Mutation_p.V122I	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	116					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			ACTTGGCAAACGTCAATAGTA	0.313												
ZSWIM2	151112	broad.mit.edu	37	2	187698688	187698688	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:187698688C>T	uc002upu.1	-	6	853	c.813G>A	c.(811-813)ACG>ACA	p.T271T		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	271	ZZ-type.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GAAATGTAAACGTGTGGGAAA	0.363												
MFSD6	54842	broad.mit.edu	37	2	191301046	191301046	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:191301046A>G	uc002urz.2	+	3	615	c.291A>G	c.(289-291)GGA>GGG	p.G97G		NM_017694	NP_060164	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing	97					transmembrane transport	integral to membrane				ovary(2)	2						AACAGCTGGGAATGTCTCCAA	0.413												
STAT1	6772	broad.mit.edu	37	2	191850352	191850352	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:191850352G>A	uc002usj.2	-	15	1644	c.1256C>T	c.(1255-1257)ACG>ATG	p.T419M	STAT1_uc010fse.1_Missense_Mutation_p.T419M|STAT1_uc002usk.2_Missense_Mutation_p.T419M|STAT1_uc002usl.2_Missense_Mutation_p.T421M|STAT1_uc010fsf.1_Missense_Mutation_p.T231M	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription	419					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	CACCTCATTCGTTCTGGTGCC	0.433												
PLCL1	5334	broad.mit.edu	37	2	198950564	198950564	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:198950564A>G	uc010fsp.2	+	2	2614	c.2323A>G	c.(2323-2325)AAT>GAT	p.N775D	PLCL1_uc002uuv.3_Missense_Mutation_p.N696D	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	775	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AAACAGTGATAATCCTATTTT	0.398												
PLCL1	5334	broad.mit.edu	37	2	198950794	198950794	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:198950794T>C	uc010fsp.2	+	2	2844	c.2553T>C	c.(2551-2553)AGT>AGC	p.S851S	PLCL1_uc002uuv.3_Silent_p.S772S	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	851					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CTAATCGAAGTGGAGGAGGAA	0.463												
PLCL1	5334	broad.mit.edu	37	2	199011601	199011601	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:199011601C>A	uc010fsp.2	+	6	3494	c.3203C>A	c.(3202-3204)CCC>CAC	p.P1068H	PLCL1_uc002uuv.3_Missense_Mutation_p.P989H	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	1068					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AGTAAAGCCCCCAGCAGCAGT	0.517												
ALS2	57679	broad.mit.edu	37	2	202625614	202625614	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:202625614A>G	uc002uyo.2	-	4	1459	c.1103T>C	c.(1102-1104)GTG>GCG	p.V368A	ALS2_uc002uyp.3_Missense_Mutation_p.V368A|ALS2_uc002uyq.2_Missense_Mutation_p.V368A|ALS2_uc002uyr.2_Missense_Mutation_p.V368A	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	368					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						CTGAGATGGCACTGGCTTTTC	0.398												
CREB1	1385	broad.mit.edu	37	2	208424959	208424959	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:208424959C>T	uc002vcc.2	+	3	375	c.124C>T	c.(124-126)CCA>TCA	p.P42S	CREB1_uc010ziz.1_Missense_Mutation_p.P40S|CREB1_uc002vcd.2_Missense_Mutation_p.P42S|CREB1_uc010zja.1_RNA	NM_134442	NP_604391	P16220	CREB1_HUMAN	cAMP responsive element binding protein 1	42					activation of phospholipase C activity|axon guidance|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein dimerization activity|transcription cofactor activity		EWSR1/CREB1(42)	soft_tissue(42)|breast(1)|central_nervous_system(1)	44				LUSC - Lung squamous cell carcinoma(261;0.0768)|Epithelial(149;0.127)|Lung(261;0.145)	Adenosine monophosphate(DB00131)|Bromocriptine(DB01200)|Naloxone(DB01183)	GGTATCTATGCCAGCAGCTCA	0.448			T	EWSR1	clear cell sarcoma|angiomatoid fibrous histiocytoma							
IKZF2	22807	broad.mit.edu	37	2	213872376	213872376	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:213872376C>A	uc002vem.2	-	8	1458	c.1289G>T	c.(1288-1290)AGG>ATG	p.R430M	IKZF2_uc010fuu.2_Missense_Mutation_p.R285M|IKZF2_uc002vej.2_Missense_Mutation_p.R377M|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.R356M|IKZF2_uc002vel.2_Missense_Mutation_p.R351M|IKZF2_uc010fuw.2_Missense_Mutation_p.R204M|IKZF2_uc010fux.2_Missense_Mutation_p.R204M|IKZF2_uc010fuy.2_Missense_Mutation_p.R358M|IKZF2_uc002ven.2_Missense_Mutation_p.R404M|IKZF2_uc002vei.2_Missense_Mutation_p.R208M	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	430					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		GCTTTGTTTCCTCTTGGGATT	0.502												
SMARCAL1	50485	broad.mit.edu	37	2	217315720	217315720	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:217315720G>A	uc002vgc.3	+	12	2333	c.2003G>A	c.(2002-2004)CGG>CAG	p.R668Q	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.R668Q|SMARCAL1_uc010fvg.2_Missense_Mutation_p.R646Q	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	668					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		GCCCCAGGACGGATCAATGCC	0.582									Schimke_Immuno-Osseous_Dysplasia			
TNS1	7145	broad.mit.edu	37	2	218678471	218678471	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:218678471C>T	uc002vgt.2	-	26	4884	c.4486G>A	c.(4486-4488)GCG>ACG	p.A1496T	TNS1_uc002vgr.2_Missense_Mutation_p.A1483T|TNS1_uc002vgs.2_Missense_Mutation_p.A1475T|TNS1_uc002vgq.2_5'UTR	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	1496	SH2.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		AGCCCGTACGCGCCTCGGAAG	0.592												
C2orf62	375307	broad.mit.edu	37	2	219229425	219229425	+	Silent	SNP	C	C	T	rs142758364		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:219229425C>T	uc002vhr.2	+	7	734	c.705C>T	c.(703-705)CAC>CAT	p.H235H	C2orf62_uc002vhs.2_Intron	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	235											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGACTGTCCACGCGGAGGAGG	0.597												
STK36	27148	broad.mit.edu	37	2	219561885	219561885	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:219561885C>A	uc002viu.2	+	23	2976	c.2710C>A	c.(2710-2712)CTA>ATA	p.L904I	STK36_uc002viv.2_Missense_Mutation_p.L883I|STK36_uc002viw.2_Missense_Mutation_p.L82I|STK36_uc002vix.2_5'UTR	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	904					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GGAGCTTTCGCTATCCAGTCC	0.522												
CCDC108	255101	broad.mit.edu	37	2	219893021	219893021	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:219893021G>A	uc002vjl.1	-	12	1837	c.1753C>T	c.(1753-1755)CGG>TGG	p.R585W	CCDC108_uc010fwa.1_Missense_Mutation_p.R28W|CCDC108_uc010zkp.1_Missense_Mutation_p.R574W|CCDC108_uc010zkq.1_Missense_Mutation_p.R520W	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	585						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTCAGGCCCCGGGCCAGGTGT	0.622												
ACSL3	2181	broad.mit.edu	37	2	223791754	223791754	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:223791754C>T	uc002vni.2	+	12	1763	c.1312C>T	c.(1312-1314)CGA>TGA	p.R438*	ACSL3_uc002vnj.2_Nonsense_Mutation_p.R438*	NM_004457	NP_004448	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	438	Cytoplasmic (Potential).				long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			ovary(2)	2		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	CCGGAAAGTTCGAAGCTTGCT	0.303			T	ETV1	prostate							
KIAA1486	57624	broad.mit.edu	37	2	226447629	226447629	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:226447629C>T	uc002voe.2	+	4	1671	c.1496C>T	c.(1495-1497)CCG>CTG	p.P499L	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.P269L	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	499										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GGGGCAGCCCCGGGTGGCTCC	0.687												
ALPI	248	broad.mit.edu	37	2	233323610	233323610	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:233323610G>A	uc002vst.3	+	11	1418	c.1341G>A	c.(1339-1341)TCG>TCA	p.S447S	ALPI_uc002vsu.3_Silent_p.S358S	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	447					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TGCCCCTGTCGTCCGAGACCC	0.692												
CHRND	1144	broad.mit.edu	37	2	233393281	233393281	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:233393281C>T	uc002vsw.2	+	5	428	c.424C>T	c.(424-426)CTG>TTG	p.L142L	CHRND_uc010zmg.1_Silent_p.L127L|CHRND_uc010fyc.2_Silent_p.G51G|CHRND_uc010zmh.1_Silent_p.G51G	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	142	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CGTGTACTGGCTGCCACCTGC	0.562												
COL6A3	1293	broad.mit.edu	37	2	238233452	238233452	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:238233452C>T	uc002vwl.2	-	44	9784	c.9499G>A	c.(9499-9501)GCC>ACC	p.A3167T	COL6A3_uc002vwo.2_Missense_Mutation_p.A2961T|COL6A3_uc010znj.1_Missense_Mutation_p.A2560T|COL6A3_uc002vwj.2_Missense_Mutation_p.A548T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	3167	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCGGGTTTGGCGAGCACTGAG	0.537												
COL6A3	1293	broad.mit.edu	37	2	238253700	238253700	+	Splice_Site	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:238253700C>T	uc002vwl.2	-	34	7447	c.7162_splice	c.e34+1	p.P2388_splice	COL6A3_uc002vwo.2_Splice_Site_p.P2182_splice|COL6A3_uc010znj.1_Splice_Site_p.P1781_splice|COL6A3_uc002vwj.2_5'Flank|COL6A3_uc002vwp.1_Splice_Site_p.P209_splice	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor						axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CATGTACTTACGGCATTTATC	0.343												
COL6A3	1293	broad.mit.edu	37	2	238277739	238277739	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:238277739C>T	uc002vwl.2	-	10	4652	c.4367G>A	c.(4366-4368)CGA>CAA	p.R1456Q	COL6A3_uc002vwo.2_Missense_Mutation_p.R1250Q|COL6A3_uc010znj.1_Missense_Mutation_p.R849Q	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1456	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AACAAAATCTCGAATATGTGC	0.458												
MYEOV2	150678	broad.mit.edu	37	2	241066179	241066179	+	Missense_Mutation	SNP	C	C	T	rs140948790		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:241066179C>T	uc002vyu.1	-	5	560	c.560G>A	c.(559-561)CGG>CAG	p.R187Q		NM_138336	NP_612209	Q8WXC6	MYOV2_HUMAN	hypothetical protein LOC150678 isoform 1	Error:Variant_position_missing_in_Q8WXC6_after_alignment											0		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		TTGGTTCTTCCGTAAACTGTT	0.483												
ANKMY1	51281	broad.mit.edu	37	2	241492466	241492466	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:241492466A>G	uc002vyz.1	-	3	307	c.78T>C	c.(76-78)CAT>CAC	p.H26H	ANKMY1_uc002vza.1_Silent_p.H115H|ANKMY1_uc010fzd.1_Silent_p.H115H|ANKMY1_uc002vzb.1_Silent_p.H115H|ANKMY1_uc002vzc.1_Silent_p.H115H|ANKMY1_uc002vzd.1_Silent_p.H115H|ANKMY1_uc010fze.1_Intron|ANKMY1_uc002vze.2_Silent_p.H17H|ANKMY1_uc002vzf.2_Silent_p.H17H	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	26	MORN 2.						zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		AAAACTGCCCATGGTATGACT	0.552												
GPR35	2859	broad.mit.edu	37	2	241569453	241569453	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:241569453C>T	uc002vzs.1	+	1	659	c.84C>T	c.(82-84)GGC>GGT	p.G28G	GPR35_uc010fzh.1_Silent_p.G59G|GPR35_uc010fzi.1_Silent_p.G59G	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	28	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		CCTACTTGGGCGTCCTGCTGG	0.627												
C2orf54	79919	broad.mit.edu	37	2	241831149	241831149	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:241831149C>T	uc002wae.3	-	2	705	c.546G>A	c.(544-546)GAG>GAA	p.E182E	C2orf54_uc002wac.2_Silent_p.E14E|C2orf54_uc002wad.2_Silent_p.E33E	NM_001085437	NP_001078906	Q08AI8	CB054_HUMAN	hypothetical protein LOC79919 isoform 1	182											0		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		GGTGGAGCTGCTCCTCCCTCA	0.652												
STK25	10494	broad.mit.edu	37	2	242439681	242439681	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:242439681G>T	uc002wbm.2	-	4	605	c.334C>A	c.(334-336)CTG>ATG	p.L112M	STK25_uc002wbk.2_5'Flank|STK25_uc002wbl.2_5'Flank|STK25_uc002wbn.2_Missense_Mutation_p.L112M|STK25_uc002wbo.2_Missense_Mutation_p.L35M|STK25_uc010zos.1_Missense_Mutation_p.L18M|STK25_uc010zot.1_Missense_Mutation_p.L38M|STK25_uc002wbp.2_Missense_Mutation_p.L112M|STK25_uc010fzo.2_Missense_Mutation_p.L35M|STK25_uc010zou.1_Missense_Mutation_p.L18M|STK25_uc010zov.1_Missense_Mutation_p.L18M|STK25_uc010zow.1_Missense_Mutation_p.L112M	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	112	Protein kinase.				response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		GTCTCCTCCAGGGGACCTGGT	0.582												
C2orf85	285093	broad.mit.edu	37	2	242815105	242815105	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:242815105G>A	uc010fzu.1	+	2	1421	c.1398G>A	c.(1396-1398)ACG>ACA	p.T466T		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	466						integral to membrane				ovary(1)	1						GCCCCATCACGGTTAGTGAGG	0.612												
PSMF1	9491	broad.mit.edu	37	20	1106263	1106263	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:1106263C>T	uc002wel.3	+	3	420	c.252C>T	c.(250-252)ACC>ACT	p.T84T	PSMF1_uc010zpo.1_5'UTR|PSMF1_uc002wem.3_Silent_p.T84T|PSMF1_uc010zpp.1_Silent_p.T84T|PSMF1_uc002wen.3_Silent_p.T84T	NM_178578	NP_848693	Q92530	PSMF1_HUMAN	proteasome inhibitor subunit 1	84					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding				0						AAGCCATCACCGTGGAGAGCA	0.493												
VPS16	64601	broad.mit.edu	37	20	2840378	2840378	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:2840378T>C	uc002whe.2	+	2	115	c.67T>C	c.(67-69)TAC>CAC	p.Y23H	VPS16_uc002whf.2_Missense_Mutation_p.Y23H|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	23					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						ATATGAGCTGTACAGCATGGA	0.542												
ProSAPiP1	9762	broad.mit.edu	37	20	3146842	3146842	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:3146842T>C	uc002wia.1	-	2	2022	c.624A>G	c.(622-624)CCA>CCG	p.P208P	ProSAPiP1_uc002wib.1_Silent_p.P208P	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	208						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						TCCCACCCGCTGGAGTCATGG	0.642												
ATRN	8455	broad.mit.edu	37	20	3565398	3565398	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:3565398G>T	uc002wim.2	+	18	3145	c.3055G>T	c.(3055-3057)GGT>TGT	p.G1019C	ATRN_uc002wil.2_Missense_Mutation_p.G1019C	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1019	Extracellular (Potential).|PSI 4.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						ATGCATAGAGGGTTCCTATAA	0.493												
SMOX	54498	broad.mit.edu	37	20	4164164	4164164	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:4164164C>T	uc002wkm.1	+	6	1594	c.1393C>T	c.(1393-1395)CGG>TGG	p.R465W	SMOX_uc002wkk.1_Missense_Mutation_p.R412W|SMOX_uc002wkl.1_Missense_Mutation_p.R412W|SMOX_uc002wkn.1_Intron|SMOX_uc002wkp.2_Missense_Mutation_p.R465W|SMOX_uc010zqo.1_Missense_Mutation_p.R389W|SMOX_uc002wko.1_Missense_Mutation_p.R465W	NM_175839	NP_787033	Q9NWM0	SMOX_HUMAN	spermine oxidase isoform 1	465					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)	1					Spermine(DB00127)	TCCAAAACCTCGGCGAATCTT	0.567												
SNAP25	6616	broad.mit.edu	37	20	10277684	10277684	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:10277684C>T	uc002wnq.1	+	6	605	c.393C>T	c.(391-393)GGC>GGT	p.G131G	SNAP25_uc002wnr.1_Silent_p.G131G|SNAP25_uc002wns.1_Silent_p.G68G|SNAP25_uc010gca.1_Silent_p.G131G|SNAP25_uc010gcb.1_Silent_p.G68G|SNAP25_uc010gcc.1_Intron	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	131					energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	CCATCAGTGGCGGCTTCATCC	0.403												
JAG1	182	broad.mit.edu	37	20	10622442	10622442	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:10622442C>T	uc002wnw.2	-	22	3187	c.2671G>A	c.(2671-2673)GCC>ACC	p.A891T	JAG1_uc010gcd.1_Missense_Mutation_p.A449T	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	891	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						TTTGAGCAGGCGATCCGTCCA	0.527									Alagille_Syndrome			
FLRT3	23767	broad.mit.edu	37	20	14308191	14308191	+	Translation_Start_Site	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:14308191G>A	uc002wov.1	-	3	429	c.-38C>T	c.(-40--36)AACGG>AATGG		MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Translation_Start_Site	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3						cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GGTAGCTTCCGTTACTTCAGA	0.388												
OTOR	56914	broad.mit.edu	37	20	16729527	16729527	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:16729527C>T	uc002wpj.2	+	2	175	c.131C>T	c.(130-132)GCT>GTT	p.A44V	OTOR_uc002wpk.2_5'Flank	NM_020157	NP_064542	Q9NRC9	OTOR_HUMAN	otoraplin precursor	44	SH3.				sensory perception of sound	extracellular region				ovary(1)|central_nervous_system(1)	2						ATTTCTCTGGCTAGTGCTCAA	0.323												
PCSK2	5126	broad.mit.edu	37	20	17462676	17462676	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:17462676C>T	uc002wpm.2	+	12	2198	c.1878C>T	c.(1876-1878)GCC>GCT	p.A626A	PCSK2_uc002wpl.2_Silent_p.A607A|PCSK2_uc010zrm.1_Silent_p.A591A|PCSK2_uc002wpn.2_Silent_p.A280A	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	626					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGACGAAGCCGTGGAGAGAA	0.592												
CSRP2BP	57325	broad.mit.edu	37	20	18143418	18143418	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:18143418G>A	uc002wqj.2	+	7	2122	c.1500G>A	c.(1498-1500)GCG>GCA	p.A500A	CSRP2BP_uc002wqk.2_Silent_p.A372A|CSRP2BP_uc010zru.1_Silent_p.A371A	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	500					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						TCAGACAAGCGAAAAGGGATA	0.468												
ZNF133	7692	broad.mit.edu	37	20	18296783	18296783	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:18296783C>T	uc010gcq.2	+	5	1593	c.1288C>T	c.(1288-1290)CGG>TGG	p.R430W	ZNF133_uc010zrv.1_Missense_Mutation_p.R433W|ZNF133_uc010zrw.1_Missense_Mutation_p.R367W|ZNF133_uc010gcr.2_Missense_Mutation_p.R430W|ZNF133_uc010zrx.1_Missense_Mutation_p.R335W|ZNF133_uc002wql.3_Missense_Mutation_p.R429W|ZNF133_uc010gcs.2_Missense_Mutation_p.R429W|ZNF133_uc010zry.1_Missense_Mutation_p.R335W|ZNF133_uc002wqm.2_Missense_Mutation_p.R430W	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	430	C2H2-type 8.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						CTCTCACAGGCGGACACACAC	0.542												
PAX1	5075	broad.mit.edu	37	20	21687147	21687147	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:21687147C>T	uc002wsj.2	+	2	412	c.358C>T	c.(358-360)CGC>TGC	p.R120C	PAX1_uc010zsl.1_Missense_Mutation_p.R120C|PAX1_uc010zsm.1_Missense_Mutation_p.R96C	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	120	Paired.				regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CAACGCCATCCGCTTGCGCAT	0.662												
PAX1	5075	broad.mit.edu	37	20	21687491	21687491	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:21687491C>T	uc002wsj.2	+	2	756	c.702C>T	c.(700-702)TAC>TAT	p.Y234Y	PAX1_uc010zsl.1_Silent_p.Y234Y|PAX1_uc010zsm.1_Silent_p.Y210Y	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	234					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CCGGACCGTACGAGGCAAGTA	0.642												
ACSS1	84532	broad.mit.edu	37	20	25011401	25011401	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:25011401T>C	uc002wub.2	-	3	1503	c.625A>G	c.(625-627)AAT>GAT	p.N209D	ACSS1_uc002wuc.2_Missense_Mutation_p.N209D|ACSS1_uc010gdc.2_Missense_Mutation_p.N209D|ACSS1_uc002wua.2_Missense_Mutation_p.N126D	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	209					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCACCATCATTGATCCTCCCA	0.587												
MAPRE1	22919	broad.mit.edu	37	20	31427543	31427543	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:31427543C>T	uc002wyh.2	+	5	617	c.478C>T	c.(478-480)CCC>TCC	p.P160S		NM_012325	NP_036457	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family,	160	Interaction with MTUS2/TIP150.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding				0						TTTTTCAGCTCCCCAGAGGCC	0.527												
CDK5RAP1	51654	broad.mit.edu	37	20	31967484	31967484	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:31967484A>G	uc010gek.2	-	9	1056	c.932T>C	c.(931-933)GTG>GCG	p.V311A	CDK5RAP1_uc002wyy.2_Missense_Mutation_p.V207A|CDK5RAP1_uc002wyz.2_Missense_Mutation_p.V297A|CDK5RAP1_uc002wza.2_Missense_Mutation_p.V297A|CDK5RAP1_uc010gel.2_Missense_Mutation_p.V206A|CDK5RAP1_uc010gem.2_Intron|CDK5RAP1_uc002wzc.1_Missense_Mutation_p.V297A	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	311					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						AAGAAGTGTCACTTCTTTCAG	0.368												
CEP250	11190	broad.mit.edu	37	20	34053898	34053898	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:34053898C>T	uc002xcm.2	+	8	1032	c.361C>T	c.(361-363)CGA>TGA	p.R121*	CEP250_uc010zve.1_5'UTR|CEP250_uc010gfe.1_RNA|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_5'Flank	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	121	Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CACCCAGCTTCGACTGCACAT	0.532												
RBM12	10137	broad.mit.edu	37	20	34241967	34241967	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:34241967A>G	uc002xdq.2	-	3	1510	c.1278T>C	c.(1276-1278)CAT>CAC	p.H426H	CPNE1_uc010zvj.1_5'Flank|CPNE1_uc002xde.2_Intron|CPNE1_uc002xdf.2_Intron|CPNE1_uc002xdg.2_Intron|CPNE1_uc010gfi.2_Intron|CPNE1_uc010gfj.2_Intron|CPNE1_uc002xdh.2_Intron|CPNE1_uc002xdi.2_Intron|CPNE1_uc002xdj.2_Intron|CPNE1_uc002xdk.2_Intron|CPNE1_uc002xdl.2_Intron|CPNE1_uc002xdm.2_Intron|CPNE1_uc010gfk.1_Intron|CPNE1_uc002xdn.1_Intron|CPNE1_uc002xdo.1_Intron|CPNE1_uc002xdp.1_Intron|RBM12_uc002xdr.2_Silent_p.H426H|RBM12_uc002xds.2_Silent_p.H426H	NM_152838	NP_690051	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	426						nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			AACCAGCCTCATGTGGTGATC	0.413											OREG0004044	type=REGULATORY REGION|Gene=CPNE1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay
RBL1	5933	broad.mit.edu	37	20	35663858	35663858	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:35663858C>T	uc002xgi.2	-	15	2036	c.1957G>A	c.(1957-1959)GCA>ACA	p.A653T	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.A653T	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	653	Pocket; binds T and E1A.|Spacer.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				GCACTCCCTGCGGTAGGAGAA	0.368												
RPN2	6185	broad.mit.edu	37	20	35835788	35835788	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:35835788A>G	uc002xgp.2	+	7	1107	c.803A>G	c.(802-804)CAC>CGC	p.H268R	RPN2_uc002xgo.3_Missense_Mutation_p.H268R|RPN2_uc010gfw.2_Missense_Mutation_p.H111R|RPN2_uc002xgq.2_Missense_Mutation_p.H236R	NM_002951	NP_002942	P04844	RPN2_HUMAN	ribophorin II isoform 1 precursor	268	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AATCGCTACCACGTGCCAGTT	0.547												
SLC32A1	140679	broad.mit.edu	37	20	37357184	37357184	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:37357184G>A	uc002xjc.2	+	2	1743	c.1480G>A	c.(1480-1482)GTC>ATC	p.V494I		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	494	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CTTCTTCGACGTCGCCATCTT	0.647												
DHX35	60625	broad.mit.edu	37	20	37662959	37662959	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:37662959C>T	uc002xjh.2	+	21	2077	c.2066C>T	c.(2065-2067)ACG>ATG	p.T689M	DHX35_uc010zwa.1_Missense_Mutation_p.T534M|DHX35_uc010zwb.1_Missense_Mutation_p.T534M|DHX35_uc010zwc.1_Missense_Mutation_p.T658M	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	689						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAACAAGGAACGGTAGGAATG	0.448												
HNF4A	3172	broad.mit.edu	37	20	43034816	43034816	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:43034816C>T	uc002xma.2	+	2	323	c.234C>T	c.(232-234)GAC>GAT	p.D78D	HNF4A_uc010zwo.1_Missense_Mutation_p.T69M|HNF4A_uc002xlt.2_Silent_p.D56D|HNF4A_uc002xlu.2_Silent_p.D56D|HNF4A_uc002xlv.2_Silent_p.D56D|HNF4A_uc002xly.2_Silent_p.D78D|HNF4A_uc002xlz.2_Silent_p.D78D|HNF4A_uc010ggq.2_Silent_p.D71D	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	78	Nuclear receptor.|NR C4-type.				blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGAGCTGTGACGGCTGCAAGG	0.547												
WFDC8	90199	broad.mit.edu	37	20	44184357	44184357	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:44184357G>A	uc002xow.2	-	4	507	c.428C>T	c.(427-429)ACG>ATG	p.T143M	WFDC8_uc002xox.2_Missense_Mutation_p.T143M	NM_181510	NP_852611	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8 precursor	143	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CATGCAGGCCGTTCTGCAGGC	0.368												
MMP9	4318	broad.mit.edu	37	20	44641107	44641107	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:44641107G>A	uc002xqz.2	+	8	1235	c.1216G>A	c.(1216-1218)GCG>ACG	p.A406T		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	406					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	GTTCGGCCACGCGCTGGGCTT	0.637												
SLC12A5	57468	broad.mit.edu	37	20	44685876	44685876	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:44685876C>T	uc010zxl.1	+	25	3338	c.3262C>T	c.(3262-3264)CGG>TGG	p.R1088W	SLC12A5_uc002xrb.2_Missense_Mutation_p.R1065W	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	1088	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GAAGAAATCCCGGGACGCCAA	0.577												
CDH22	64405	broad.mit.edu	37	20	44815281	44815281	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:44815281G>A	uc002xrm.2	-	9	2010	c.1609C>T	c.(1609-1611)CGC>TGC	p.R537C	CDH22_uc010ghk.1_Missense_Mutation_p.R537C	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	537	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGCACCAGGCGGAAATAGAAG	0.587												
ARFGEF2	10564	broad.mit.edu	37	20	47605849	47605849	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:47605849T>G	uc002xtx.3	+	19	2713	c.2561T>G	c.(2560-2562)CTG>CGG	p.L854R	ARFGEF2_uc010zyf.1_Missense_Mutation_p.L147R	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	854					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CAGCGGCGGCTGCTGTACAAC	0.393												
ARFGEF2	10564	broad.mit.edu	37	20	47611069	47611069	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:47611069C>T	uc002xtx.3	+	22	3207	c.3055C>T	c.(3055-3057)CGT>TGT	p.R1019C	ARFGEF2_uc010zyf.1_Missense_Mutation_p.R312C	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	1019					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TGGATCTGGGCGTGAAAGAGA	0.557												
SNAI1	6615	broad.mit.edu	37	20	48604589	48604589	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:48604589G>A	uc002xuz.2	+	3	861	c.791G>A	c.(790-792)CGC>CAC	p.R264H		NM_005985	NP_005976	O95863	SNAI1_HUMAN	snail 1 homolog	264					epithelial to mesenchymal transition|mesoderm formation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|zinc ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			GGATGTCCCCGCTGACCCTCG	0.612												
ADNP	23394	broad.mit.edu	37	20	49508895	49508895	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:49508895T>G	uc002xvt.1	-	5	2701	c.2356A>C	c.(2356-2358)ATT>CTT	p.I786L	ADNP_uc002xvu.1_Missense_Mutation_p.I786L	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	786	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						AGCTTCTCAATTTCTCTCCTG	0.413												
ZNF217	7764	broad.mit.edu	37	20	52193292	52193292	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:52193292C>T	uc002xwq.3	-	3	2282	c.2011G>A	c.(2011-2013)GCA>ACA	p.A671T	ZNF217_uc010gij.1_Missense_Mutation_p.A663T	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	671					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CAGTCAGCTGCGGTCTCCGTT	0.483												
NPEPL1	79716	broad.mit.edu	37	20	57269569	57269569	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:57269569G>A	uc010zzs.1	+	3	523	c.428G>A	c.(427-429)CGC>CAC	p.R143H	NPEPL1_uc010zzr.1_Missense_Mutation_p.R95H|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Missense_Mutation_p.R115H|NPEPL1_uc002xzp.2_Missense_Mutation_p.R31H	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	143					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			GCCTCTCGGCGCTTGGAGAAG	0.637												
ZNF831	128611	broad.mit.edu	37	20	57768886	57768886	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:57768886T>C	uc002yan.2	+	1	2812	c.2812T>C	c.(2812-2814)TCC>CCC	p.S938P		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	938						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TAATGCCTTTTCCCCCAAGTA	0.637												
CDH26	60437	broad.mit.edu	37	20	58563985	58563985	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:58563985G>A	uc002ybe.2	+	9	1350	c.1050G>A	c.(1048-1050)GCG>GCA	p.A350A	CDH26_uc002ybf.1_5'UTR|CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	350	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CTCGCCCAGCGCAAAGCCTCA	0.572												
NTSR1	4923	broad.mit.edu	37	20	61391505	61391505	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:61391505C>G	uc002ydf.2	+	4	1514	c.1143C>G	c.(1141-1143)TGC>TGG	p.C381W		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	381	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CACTGGCCTGCCTCTGCCCGG	0.627												
YTHDF1	54915	broad.mit.edu	37	20	61834535	61834535	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:61834535C>T	uc002yeh.2	-	4	1051	c.757G>A	c.(757-759)GGG>AGG	p.G253R	YTHDF1_uc011aaq.1_Missense_Mutation_p.G203R	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	253	Gln/Pro-rich.									ovary(2)	2						ATGACAGGCCCGCTCTTTGTT	0.572												
KCNQ2	3785	broad.mit.edu	37	20	62070960	62070960	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:62070960C>T	uc002yey.1	-	6	1095	c.918G>A	c.(916-918)GCG>GCA	p.A306A	KCNQ2_uc002yez.1_Silent_p.A306A|KCNQ2_uc002yfa.1_Silent_p.A306A|KCNQ2_uc002yfb.1_Silent_p.A306A|KCNQ2_uc011aax.1_Silent_p.A306A|KCNQ2_uc002yfc.1_Silent_p.A306A	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	306	Helical; Name=Segment S6; (Potential).		A -> T (in EBN1; 20%-40% reduction of wt heteromeric current. Ratio of 1:1:2).		axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CTGCAGGCAGCGCGAAGAAGG	0.637												
SRMS	6725	broad.mit.edu	37	20	62178751	62178751	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:62178751C>T	uc002yfi.1	-	1	107	c.66G>A	c.(64-66)GCG>GCA	p.A22A		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	22							ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GCTCGCCGCCCGCCGGCCAGA	0.711												
PRIC285	85441	broad.mit.edu	37	20	62196899	62196899	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:62196899G>A	uc002yfm.2	-	9	4168	c.3276C>T	c.(3274-3276)GAC>GAT	p.D1092D	PRIC285_uc002yfl.1_Silent_p.D523D	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1092					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCAGCAGCCCGTCCTCCCCGA	0.682												
UCKL1	54963	broad.mit.edu	37	20	62577179	62577179	+	Silent	SNP	C	C	T	rs61743506	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:62577179C>T	uc010gkn.2	-	4	604	c.561G>A	c.(559-561)ACG>ACA	p.T187T	UCKL1_uc011abm.1_Silent_p.T172T|UCKL1_uc011abn.1_RNA|UCKL1_uc011abo.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	187					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					TCCGGCTGTGCGTGGTGAAGT	0.592												
ZNF512B	57473	broad.mit.edu	37	20	62598745	62598745	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:62598745G>A	uc002yhl.1	-	3	307	c.253C>T	c.(253-255)CGA>TGA	p.R85*		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GGAATGTCTCGGAGGGCCTGG	0.622												
OPRL1	4987	broad.mit.edu	37	20	62729786	62729786	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:62729786G>A	uc002yic.2	+	5	1149	c.747G>A	c.(745-747)TCG>TCA	p.S249S	OPRL1_uc002yid.2_Silent_p.S249S|OPRL1_uc002yif.3_Silent_p.S244S	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	249	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GCCTGCTCTCGGGCTCCCGAG	0.632												
NRIP1	8204	broad.mit.edu	37	21	16338141	16338141	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:16338141G>A	uc002yjx.2	-	4	2971	c.2373C>T	c.(2371-2373)AGC>AGT	p.S791S		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	791	Repression domain 3.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		AGGCAGGTGCGCTTCTCTGCA	0.468												
GRIK1	2897	broad.mit.edu	37	21	30949413	30949413	+	Silent	SNP	C	C	T	rs142518822	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:30949413C>T	uc002yno.1	-	14	2465	c.2001G>A	c.(1999-2001)ACG>ACA	p.T667T	GRIK1_uc002ynn.2_Silent_p.T652T|GRIK1_uc011acs.1_Silent_p.T667T|GRIK1_uc011act.1_Silent_p.T528T	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	667	Helical; (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CCAGATTGGCCGTGTAGGATG	0.463												
KRTAP15-1	254950	broad.mit.edu	37	21	31812904	31812904	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:31812904C>T	uc002yod.2	+	1	259	c.259C>T	c.(259-261)CGC>TGC	p.R87C		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	87						intermediate filament					0						CTGCAGTCCCCGCCAGACTAA	0.522												
TIAM1	7074	broad.mit.edu	37	21	32493037	32493037	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:32493037G>A	uc002yow.1	-	29	4897	c.4425C>T	c.(4423-4425)CCC>CCT	p.P1475P	TIAM1_uc011adk.1_3'UTR|TIAM1_uc011adl.1_Silent_p.P1415P	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1475					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CCCCACCACCGGGGGGCTGCT	0.572												
GART	2618	broad.mit.edu	37	21	34903066	34903066	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:34903066T>C	uc002yrx.2	-	7	857	c.722A>G	c.(721-723)CAG>CGG	p.Q241R	GART_uc002yrz.2_Missense_Mutation_p.Q241R|GART_uc010gmd.2_5'UTR|GART_uc002yry.2_Missense_Mutation_p.Q241R|GART_uc002ysa.2_Missense_Mutation_p.Q241R	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	241	ATP-grasp.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	GGGAAGTACCTGAGGGGCTGG	0.483												
SIM2	6493	broad.mit.edu	37	21	38115733	38115733	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:38115733C>A	uc002yvr.2	+	9	1100	c.1044C>A	c.(1042-1044)TCC>TCA	p.S348S	SIM2_uc002yvq.2_Silent_p.S348S	NM_005069	NP_005060	Q14190	SIM2_HUMAN	single-minded homolog 2 long isoform	348	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1						AGCAGGTGTCCACTGCCAAGT	0.537												
TTC3	7267	broad.mit.edu	37	21	38498385	38498385	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:38498385G>A	uc002yvz.2	+	15	1344	c.1239G>A	c.(1237-1239)GCG>GCA	p.A413A	TTC3_uc011aee.1_Silent_p.A103A|TTC3_uc002ywa.2_Silent_p.A413A|TTC3_uc002ywb.2_Silent_p.A413A|TTC3_uc010gnf.2_Silent_p.A178A|TTC3_uc002ywc.2_Silent_p.A103A|TTC3_uc011aed.1_Silent_p.A103A|TTC3_uc010gne.1_Silent_p.A413A	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	413					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				GGCAGGTGGCGGATGAGGCGT	0.328												
DSCR3	10311	broad.mit.edu	37	21	38600102	38600102	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:38600102C>T	uc002ywf.1	-	8	903	c.664G>A	c.(664-666)GCA>ACA	p.A222T	DSCR3_uc010gnm.1_RNA|DSCR3_uc010gnn.1_Missense_Mutation_p.A180T|DSCR3_uc010gnl.2_Missense_Mutation_p.A195T|DSCR3_uc011aeg.1_Missense_Mutation_p.A145T|DSCR3_uc011aeh.1_Missense_Mutation_p.A97T	NM_006052	NP_006043	O14972	DSCR3_HUMAN	Down syndrome critical region protein 3	222					vacuolar transport	nucleus|retromer complex					0						TAGCCTTCTGCACACCCTGCG	0.642												
RIPK4	54101	broad.mit.edu	37	21	43161498	43161498	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:43161498C>T	uc002yzn.1	-	8	1903	c.1855G>A	c.(1855-1857)GTG>ATG	p.V619M		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	619						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						ATGCGGGCCACGCGGTAGTGC	0.687												
UMODL1	89766	broad.mit.edu	37	21	43531694	43531694	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:43531694G>T	uc002zaf.1	+	12	1978	c.1978G>T	c.(1978-1980)GCC>TCC	p.A660S	UMODL1_uc002zad.1_Missense_Mutation_p.A588S|UMODL1_uc002zae.1_Missense_Mutation_p.A716S|UMODL1_uc002zag.1_Missense_Mutation_p.A788S	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	660	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CCTGTGGCATGCCACCCGTTC	0.617												
CBS	875	broad.mit.edu	37	21	44480625	44480625	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:44480625G>A	uc002zcu.2	-	12	1316	c.1071C>T	c.(1069-1071)GCC>GCT	p.A357A	CBS_uc002zcs.1_Silent_p.A252A|CBS_uc002zct.2_Silent_p.A357A|CBS_uc002zcw.3_Silent_p.A357A|CBS_uc002zcv.2_Silent_p.A357A|CBS_uc002zcx.2_5'UTR	NM_000071	NP_000062	P35520	CBS_HUMAN	cystathionine-beta-synthase	357					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	CGGCCTTCACGGCCACCGCCA	0.652												
RRP1	8568	broad.mit.edu	37	21	45219516	45219516	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:45219516G>A	uc002zds.2	+	9	970	c.877G>A	c.(877-879)GGC>AGC	p.G293S	RRP1_uc011aez.1_Missense_Mutation_p.G293S|RRP1_uc010gpk.1_Missense_Mutation_p.G143S|RRP1_uc010gpl.1_Missense_Mutation_p.G191S|RRP1_uc010gpm.1_Missense_Mutation_p.G160S	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	293					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		GGACAGTGGCGGCCCCGTTCT	0.637												
PWP2	5822	broad.mit.edu	37	21	45535691	45535691	+	Silent	SNP	A	A	G	rs145366296		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:45535691A>G	uc002zeb.2	+	7	816	c.726A>G	c.(724-726)GAA>GAG	p.E242E		NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	242	Poly-Glu.					cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		Gggaggaggaagaggaggagg	0.517												
TRPM2	7226	broad.mit.edu	37	21	45798982	45798982	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:45798982G>A	uc002zet.1	+	9	1330	c.1117G>A	c.(1117-1119)GAC>AAC	p.D373N	TRPM2_uc002zeu.1_Missense_Mutation_p.D373N|TRPM2_uc002zew.1_Missense_Mutation_p.D373N|TRPM2_uc010gpt.1_Missense_Mutation_p.D373N|TRPM2_uc002zex.1_Missense_Mutation_p.D159N	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	373	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCCTGTCTCGGACATCACTAT	0.582												
TRPM2	7226	broad.mit.edu	37	21	45825802	45825802	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:45825802C>T	uc002zet.1	+	19	2885	c.2672C>T	c.(2671-2673)ACG>ATG	p.T891M	TRPM2_uc002zeu.1_Missense_Mutation_p.T891M|TRPM2_uc002zew.1_Missense_Mutation_p.T891M|TRPM2_uc010gpt.1_Missense_Mutation_p.T891M|TRPM2_uc002zex.1_Missense_Mutation_p.T677M|TRPM2_uc002zey.1_Missense_Mutation_p.T404M	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	891	Helical; (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ATCCCGGCGACGCTGTACCCC	0.637												
ADARB1	104	broad.mit.edu	37	21	46596311	46596311	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:46596311G>T	uc002zgy.2	+	4	1130	c.695G>T	c.(694-696)AGT>ATT	p.S232I	ADARB1_uc002zgr.2_Missense_Mutation_p.S232I|ADARB1_uc002zgs.2_RNA|ADARB1_uc002zgw.2_Missense_Mutation_p.S232I|ADARB1_uc002zgv.2_RNA|ADARB1_uc002zgt.2_Missense_Mutation_p.S232I|ADARB1_uc010gpx.2_Intron|ADARB1_uc002zgq.2_RNA|ADARB1_uc002zgu.2_RNA|ADARB1_uc011afo.1_Missense_Mutation_p.S281I	NM_015833	NP_056648	P78563	RED1_HUMAN	RNA-specific adenosine deaminase B1 isoform 2	232	DRBM 2.				adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			skin(1)	1				Colorectal(79;0.115)		CCACCCCCGAGTGGGAAGAAT	0.597												
PCBP3	54039	broad.mit.edu	37	21	47360075	47360075	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:47360075G>A	uc002zhq.1	+	13	1166	c.1041G>A	c.(1039-1041)CCG>CCA	p.P347P	PCBP3_uc002zhp.1_Silent_p.P327P|PCBP3_uc002zhs.1_Silent_p.P321P|PCBP3_uc002zhr.1_Silent_p.P346P|PCBP3_uc002zht.1_Silent_p.P337P	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	347	KH 3.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CGGGGACCCCGGCCAACATCA	0.572												
CCT8L2	150160	broad.mit.edu	37	22	17072267	17072267	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:17072267C>T	uc002zlp.1	-	1	1434	c.1174G>A	c.(1174-1176)GTC>ATC	p.V392I		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	392					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCGTGGTAGACGGCCTGCTCT	0.542												
CCT8L2	150160	broad.mit.edu	37	22	17072678	17072678	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:17072678C>A	uc002zlp.1	-	1	1023	c.763G>T	c.(763-765)GCA>TCA	p.A255S		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	255					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GTTGCTGGTGCATTTGGATGG	0.507												
DGCR2	9993	broad.mit.edu	37	22	19055664	19055664	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:19055664C>T	uc002zoq.1	-	3	525	c.277G>A	c.(277-279)GAC>AAC	p.D93N	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Missense_Mutation_p.D52N	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	93	Extracellular (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					TGCGAAGGGTCGCCTCCTCTG	0.627												
HIRA	7290	broad.mit.edu	37	22	19379688	19379688	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:19379688G>A	uc002zpf.1	-	9	1092	c.872C>T	c.(871-873)GCG>GTG	p.A291V	HIRA_uc011agx.1_Missense_Mutation_p.A157V|HIRA_uc010grn.1_Missense_Mutation_p.A291V|HIRA_uc010gro.1_Missense_Mutation_p.A247V|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	291	WD 6.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GCTAGGCTTCGCAGAACTCCC	0.458												
KLHL22	84861	broad.mit.edu	37	22	20819360	20819360	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:20819360G>A	uc002zsl.1	-	4	1006	c.897C>T	c.(895-897)TGC>TGT	p.C299C	KLHL22_uc011ahr.1_Silent_p.C156C|KLHL22_uc002zsm.1_Silent_p.C299C	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	299	Kelch 1.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AGCCCACAACGCACTGGAAGT	0.617												
LZTR1	8216	broad.mit.edu	37	22	21351217	21351217	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:21351217C>T	uc002zto.2	+	20	2471	c.2368C>T	c.(2368-2370)CGG>TGG	p.R790W	LZTR1_uc002ztn.2_Missense_Mutation_p.R749W|LZTR1_uc011ahy.1_Missense_Mutation_p.R771W|LZTR1_uc002ztp.2_Missense_Mutation_p.R96W	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	790					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GGACATGAAGCGGCACTGCCT	0.617												
PIWIL3	440822	broad.mit.edu	37	22	25145382	25145382	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:25145382A>G	uc003abd.1	-	11	1740	c.1323T>C	c.(1321-1323)AAT>AAC	p.N441N	PIWIL3_uc011ajx.1_Silent_p.N332N|PIWIL3_uc011ajy.1_Silent_p.N332N|PIWIL3_uc010gut.1_Silent_p.N441N	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	441					cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						CTTGTAGAGTATTGATGAATT	0.398												
HPS4	89781	broad.mit.edu	37	22	26861510	26861510	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:26861510T>C	uc003acl.2	-	10	1373	c.714A>G	c.(712-714)GCA>GCG	p.A238A	HPS4_uc003aci.2_Silent_p.A233A|HPS4_uc003acj.2_Silent_p.A102A|HPS4_uc003ack.2_Silent_p.A29A|HPS4_uc003acn.2_Silent_p.A84A|HPS4_uc010gvd.1_Silent_p.A256A|HPS4_uc003ach.2_5'UTR	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	238					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						TCGGGGGCAATGCCGCTCCTG	0.527									Hermansky-Pudlak_syndrome			
HPS4	89781	broad.mit.edu	37	22	26868359	26868359	+	Missense_Mutation	SNP	G	G	A	rs150403254	by1000genomes	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:26868359G>A	uc003acl.2	-	6	1069	c.410C>T	c.(409-411)ACG>ATG	p.T137M	HPS4_uc003aci.2_Missense_Mutation_p.T132M|HPS4_uc003acj.2_Translation_Start_Site|HPS4_uc003ack.2_Translation_Start_Site|HPS4_uc003acn.2_Translation_Start_Site|HPS4_uc010gvd.1_Missense_Mutation_p.T137M|HPS4_uc003ach.2_Translation_Start_Site	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	137					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						GTCCCACTCCGTGCTCAGTTC	0.423									Hermansky-Pudlak_syndrome			
CRYBB1	1414	broad.mit.edu	37	22	27012211	27012211	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:27012211C>A	uc003acy.1	-	2	143	c.73G>T	c.(73-75)GGG>TGG	p.G25W		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	25	N-terminal arm.				visual perception		structural constituent of eye lens			ovary(1)	1						GGTGGGGCCCCCTTCCCCTTG	0.637												
AP1B1	162	broad.mit.edu	37	22	29755831	29755831	+	Silent	SNP	G	G	A	rs143484030	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:29755831G>A	uc003afj.2	-	4	445	c.261C>T	c.(259-261)GCC>GCT	p.A87A	AP1B1_uc003afi.2_Silent_p.A87A|AP1B1_uc003afk.2_Silent_p.A87A|AP1B1_uc003afl.2_Silent_p.A87A	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	87					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						AGGTGTTGACGGCCATAATGG	0.547											OREG0026449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
MYH9	4627	broad.mit.edu	37	22	36702620	36702620	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:36702620C>T	uc003apg.2	-	16	2108	c.1877G>A	c.(1876-1878)GGC>GAC	p.G626D	MYH9_uc003aph.1_Missense_Mutation_p.G490D	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	626	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CTCCGACATGCCGGCCACCTG	0.637			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated			
MYH9	4627	broad.mit.edu	37	22	36708256	36708256	+	Silent	SNP	C	C	T	rs145517108	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:36708256C>T	uc003apg.2	-	14	1797	c.1566G>A	c.(1564-1566)CCG>CCA	p.P522P	MYH9_uc003aph.1_Silent_p.P386P	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	522	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						CCAGAATGCCCGGGGGGCCTG	0.637			T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated			
PLA2G6	8398	broad.mit.edu	37	22	38525530	38525530	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:38525530C>T	uc003auy.1	-	8	1253	c.1117G>A	c.(1117-1119)GGA>AGA	p.G373R	PLA2G6_uc003auz.1_Missense_Mutation_p.G373R|PLA2G6_uc003ava.1_Missense_Mutation_p.G373R|PLA2G6_uc003avb.2_Missense_Mutation_p.G373R|PLA2G6_uc010gxk.1_RNA|PLA2G6_uc011ano.1_Missense_Mutation_p.G338R	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	373	ANK 7.				cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	ACTTCTGCTCCGAACACGATG	0.542												
KCNJ4	3761	broad.mit.edu	37	22	38823343	38823343	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:38823343G>A	uc003avs.1	-	2	892	c.795C>T	c.(793-795)ATC>ATT	p.I265I	KCNJ4_uc003avt.1_Silent_p.I265I	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	265	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					TGTCCTCGTCGATCTCGTGGA	0.617												
TAB1	10454	broad.mit.edu	37	22	39826041	39826041	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:39826041G>T	uc003axt.2	+	11	1378	c.1329G>T	c.(1327-1329)CTG>CTT	p.L443L	TAB1_uc003axr.2_Silent_p.L519L|TAB1_uc011aok.1_Silent_p.L277L|TAB1_uc003axu.1_Intron	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	443					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						CCTTAACCCTGCAGTCCACCA	0.672												
EP300	2033	broad.mit.edu	37	22	41564766	41564766	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:41564766G>A	uc003azl.3	+	25	4462	c.4067G>A	c.(4066-4068)CGA>CAA	p.R1356Q		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1356					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTTCCATACCGAACCAAAGCC	0.468			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome			
RANGAP1	5905	broad.mit.edu	37	22	41652106	41652106	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:41652106T>C	uc003azs.2	-	9	2462	c.992A>G	c.(991-993)AAC>AGC	p.N331S	RANGAP1_uc003azt.2_Missense_Mutation_p.N331S|RANGAP1_uc003azu.2_Missense_Mutation_p.N331S|RANGAP1_uc011aoz.1_Missense_Mutation_p.N276S	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	331	LRR 6.				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						TCCCAGGGTGTTGCCTGCTCA	0.632												
SCUBE1	80274	broad.mit.edu	37	22	43604220	43604220	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:43604220C>A	uc003bdt.1	-	20	2680	c.2592G>T	c.(2590-2592)ACG>ACT	p.T864T		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	864	CUB.				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				TGGTGATGGACGTGGGAGAGG	0.453												
FBLN1	2192	broad.mit.edu	37	22	45972965	45972965	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:45972965G>A	uc003bgj.1	+	16	2096	c.1949G>A	c.(1948-1950)CGT>CAT	p.R650H		NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	650					interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		ATCATCAAGCGTTACATGGAC	0.597												
C22orf40	150383	broad.mit.edu	37	22	46643046	46643046	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:46643046C>T	uc003bhe.2	-	3	227	c.186G>A	c.(184-186)TCG>TCA	p.S62S	C22orf40_uc003bhc.2_Silent_p.S62S|C22orf40_uc003bhd.2_Silent_p.S62S|C22orf40_uc003bhf.2_RNA	NM_207327	NP_997210	Q6NVV7	CV040_HUMAN	hypothetical protein LOC150383	62											0						AACTGCAGCACGAGCCGAGGA	0.597												
PKDREJ	10343	broad.mit.edu	37	22	46658051	46658051	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:46658051C>T	uc003bhh.2	-	1	1169	c.1169G>A	c.(1168-1170)CGA>CAA	p.R390Q		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	390	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CAGGATTATTCGATCCCCACC	0.567												
GRAMD4	23151	broad.mit.edu	37	22	47064782	47064782	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:47064782A>T	uc003bhx.2	+	12	1100	c.1061A>T	c.(1060-1062)TAC>TTC	p.Y354F	GRAMD4_uc010had.2_Missense_Mutation_p.Y293F	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	354	Helical; (Potential).				apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		TTCTTCCCCTACCGCCTGGTG	0.617												
TUBGCP6	85378	broad.mit.edu	37	22	50663014	50663014	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:50663014C>T	uc003bkb.1	-	11	2503	c.1991G>A	c.(1990-1992)CGT>CAT	p.R664H	TUBGCP6_uc003bka.1_5'Flank|TUBGCP6_uc010har.1_Missense_Mutation_p.R664H|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hat.1_5'UTR|TUBGCP6_uc003bkd.1_Missense_Mutation_p.R18H	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	664					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AATTTCCATACGTAATTCCTG	0.338												
PLXNB2	23654	broad.mit.edu	37	22	50716155	50716155	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:50716155C>T	uc003bkv.3	-	33	5167	c.5061G>A	c.(5059-5061)CGG>CGA	p.R1687R	PLXNB2_uc003bkt.1_Silent_p.R479R|PLXNB2_uc003bku.1_Silent_p.R672R	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1687	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TCACCCAGAACCGGAGCGGTA	0.642												
PLXNB2	23654	broad.mit.edu	37	22	50728968	50728968	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:50728968C>T	uc003bkv.3	-	3	152	c.46G>A	c.(46-48)GCA>ACA	p.A16T		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	16					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTGGCACCTGCGCCCAGCAGG	0.677												
SCO2	9997	broad.mit.edu	37	22	50962178	50962178	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:50962178G>A	uc003bma.2	-	2	839	c.663C>T	c.(661-663)ATC>ATT	p.I221I	SCO2_uc003blz.3_Silent_p.I221I	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	221	Thioredoxin.				cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGTGGTCCACGATGTAGTCCT	0.572												
SHANK3	85358	broad.mit.edu	37	22	51160465	51160465	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:51160465G>A	uc003bne.1	+	22	4252	c.4252G>A	c.(4252-4254)GGA>AGA	p.G1418R	SHANK3_uc003bnf.1_Missense_Mutation_p.G865R|SHANK3_uc010hbg.1_Missense_Mutation_p.G600R	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1418										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CTTCGCTGACGGACACACTTT	0.617												
GRM7	2917	broad.mit.edu	37	3	7503408	7503408	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:7503408A>T	uc003bqm.2	+	7	1788	c.1514A>T	c.(1513-1515)AAT>ATT	p.N505I	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.N505I|GRM7_uc003bql.2_Missense_Mutation_p.N505I|GRM7_uc003bqn.1_Missense_Mutation_p.N88I|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	505	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CTTCAGCTCAATGTGAGTTCT	0.443												
RFTN1	23180	broad.mit.edu	37	3	16358730	16358730	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:16358730G>A	uc003cay.2	-	10	1624	c.1342C>T	c.(1342-1344)CGA>TGA	p.R448*	RFTN1_uc010hes.2_Nonsense_Mutation_p.R412*|OXNAD1_uc003cax.2_Intron|OXNAD1_uc011awb.1_Intron	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	448						plasma membrane		p.R448*(1)		ovary(3)|central_nervous_system(1)	4						CTGGAGAATCGCCACTGAAAC	0.438												
PLCL2	23228	broad.mit.edu	37	3	17051544	17051544	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:17051544G>A	uc011awc.1	+	5	787	c.682G>A	c.(682-684)GCA>ACA	p.A228T	PLCL2_uc010het.1_Missense_Mutation_p.A110T|PLCL2_uc011awd.1_Missense_Mutation_p.A110T	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	236	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						TGCCAACTCCGCAGATGTTGC	0.413												
RAB5A	5868	broad.mit.edu	37	3	20025266	20025266	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:20025266A>G	uc003cbn.2	+	6	1134	c.599A>G	c.(598-600)GAC>GGC	p.D200G	RAB5A_uc010hey.2_RNA|RAB5A_uc011awg.1_Missense_Mutation_p.D186G|C3orf48_uc010hez.2_Intron	NM_004162	NP_004153	P20339	RAB5A_HUMAN	RAB5A, member RAS oncogene family	200					blood coagulation|protein transport|receptor internalization|regulation of filopodium assembly|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GDP binding|GTP binding|GTPase activity				0						AGAGGAGTAGACCTTACCGAA	0.368												
KAT2B	8850	broad.mit.edu	37	3	20153198	20153198	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:20153198G>A	uc003cbq.2	+	6	1408	c.962G>A	c.(961-963)CGA>CAA	p.R321Q		NM_003884	NP_003875	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	321					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTTATGAGGCGACAACTCCTG	0.463												
SGOL1	151648	broad.mit.edu	37	3	20225413	20225413	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:20225413C>T	uc003cbs.2	-	2	294	c.107G>A	c.(106-108)CGC>CAC	p.R36H	SGOL1_uc003cbr.2_Missense_Mutation_p.R36H|SGOL1_uc010hfa.2_Missense_Mutation_p.R36H|SGOL1_uc003cbt.2_Missense_Mutation_p.R36H|SGOL1_uc003cbu.2_Missense_Mutation_p.R36H|SGOL1_uc003cbv.2_Missense_Mutation_p.R36H|SGOL1_uc003cbw.2_Missense_Mutation_p.R36H|SGOL1_uc003cbx.2_Missense_Mutation_p.R36H|SGOL1_uc003cby.2_Missense_Mutation_p.R36H|SGOL1_uc003cbz.2_Missense_Mutation_p.R36H|SGOL1_uc003cca.2_Missense_Mutation_p.R36H|SGOL1_uc003ccb.2_Missense_Mutation_p.R36H|SGOL1_uc003ccc.2_Missense_Mutation_p.R36H	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	36	Potential.|Necessary for interaction with PPP2CA and PPP2R1A.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						AAAAGACCTGCGTTTGCCAAT	0.318												
PDCD6IP	10015	broad.mit.edu	37	3	33877588	33877588	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:33877588A>T	uc003cfx.2	+	8	1042	c.887A>T	c.(886-888)AAT>ATT	p.N296I	PDCD6IP_uc003cfy.2_Missense_Mutation_p.N301I|PDCD6IP_uc011axw.1_Missense_Mutation_p.N77I	NM_013374	NP_037506	Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	296	Interaction with EIAV p9.|Interaction with CHMP4A, CHMP4B and CHMP4C.|BRO1.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			ovary(1)|skin(1)	2						GAATATGTTAATGTGAAGGAT	0.358												
LRRFIP2	9209	broad.mit.edu	37	3	37170567	37170567	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:37170567C>T	uc003cgp.2	-	4	587	c.164G>A	c.(163-165)CGA>CAA	p.R55Q	LRRFIP2_uc011ayf.1_Missense_Mutation_p.R55Q|LRRFIP2_uc003cgr.2_Missense_Mutation_p.R55Q|LRRFIP2_uc003cgs.3_Missense_Mutation_p.R55Q|LRRFIP2_uc003cgt.3_Missense_Mutation_p.R55Q	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	55	DVL3-binding.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						TTTTTGTTGTCGTTCCAGTTC	0.428												
XYLB	9942	broad.mit.edu	37	3	38414150	38414150	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:38414150C>T	uc003cic.2	+	10	879	c.770C>T	c.(769-771)GCC>GTC	p.A257V	XYLB_uc011ayp.1_Missense_Mutation_p.A120V|XYLB_uc003cid.1_Missense_Mutation_p.A179V	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	257					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		CCTCAGGGAGCCATTTCTTCC	0.572												
ZNF167	55888	broad.mit.edu	37	3	44612793	44612793	+	Missense_Mutation	SNP	C	C	T	rs148767433		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:44612793C>T	uc010hin.2	+	6	2579	c.2191C>T	c.(2191-2193)CGT>TGT	p.R731C	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.R731C|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	731	C2H2-type 13.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		CTTTAGTCAGCGTTCCACTTT	0.463												
PTH1R	5745	broad.mit.edu	37	3	46943318	46943318	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:46943318C>T	uc003cqm.2	+	13	1382	c.1179C>T	c.(1177-1179)AAC>AAT	p.N393N	PTH1R_uc003cqn.2_Silent_p.N393N	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	393	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GGGAGACCAACGCCGGCCGGT	0.642									Ollier_disease_/_Maffuci_syndrome			
NBEAL2	23218	broad.mit.edu	37	3	47050494	47050494	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:47050494G>A	uc003cqp.2	+	53	8222	c.8043G>A	c.(8041-8043)GCG>GCA	p.A2681A	NRADDP_uc011bas.1_5'Flank|NBEAL2_uc010hjm.1_Silent_p.A2058A|NBEAL2_uc010hjn.1_Silent_p.A1047A|NBEAL2_uc010hjo.1_Silent_p.A241A	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2681							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TCCCGGCCGCGCCTCCCTTGC	0.622												
ARIH2	10425	broad.mit.edu	37	3	49004710	49004710	+	Splice_Site	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:49004710T>C	uc003cvb.2	+	6	850	c.538_splice	c.e6+2	p.G180_splice	ARIH2_uc003cvc.2_Splice_Site_p.G180_splice|ARIH2_uc003cvf.2_Splice_Site_p.G98_splice|ARIH2_uc010hkl.2_Splice_Site_p.G180_splice	NM_006321	NP_006312	O95376	ARI2_HUMAN	ariadne homolog 2						developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		TGGGCGTGGGTGAGTCTGCCA	0.488												
LAMB2	3913	broad.mit.edu	37	3	49159606	49159606	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:49159606G>A	uc003cwe.2	-	28	5070	c.4771C>T	c.(4771-4773)CGG>TGG	p.R1591W	USP19_uc003cvz.3_5'Flank|USP19_uc011bcg.1_5'Flank|USP19_uc003cwb.2_5'Flank|USP19_uc003cwd.1_5'Flank|USP19_uc011bch.1_5'Flank|USP19_uc011bci.1_5'Flank	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1591	Potential.|Domain I.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTTGCCCGCCGTGCATCCTGC	0.612												
AMIGO3	386724	broad.mit.edu	37	3	49756307	49756307	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:49756307T>C	uc003cxj.2	-	1	932	c.592A>G	c.(592-594)ATC>GTC	p.I198V	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	198	Extracellular (Potential).|LRR 6.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGTACGGAGATGTGTCCCAGC	0.627											OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
CAMKV	79012	broad.mit.edu	37	3	49897038	49897038	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:49897038C>T	uc003cxt.1	-	11	1412	c.1219G>A	c.(1219-1221)GAT>AAT	p.D407N	CAMKV_uc011bcy.1_Missense_Mutation_p.D332N|CAMKV_uc003cxv.1_Missense_Mutation_p.D379N|CAMKV_uc003cxw.1_Missense_Mutation_p.D239N|CAMKV_uc003cxx.1_Missense_Mutation_p.D239N|CAMKV_uc003cxu.2_Missense_Mutation_p.D376N|CAMKV_uc011bcz.1_Missense_Mutation_p.D339N|CAMKV_uc011bda.1_Missense_Mutation_p.D333N	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	407	Ala-rich.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ATGCTTCCATCGGTGGCTGGG	0.607												
RBM6	10180	broad.mit.edu	37	3	50099537	50099537	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:50099537C>T	uc003cyc.2	+	15	2715	c.2582C>T	c.(2581-2583)ACG>ATG	p.T861M	RBM6_uc010hlc.1_Missense_Mutation_p.T380M|RBM6_uc003cyd.2_Missense_Mutation_p.T339M|RBM6_uc003cye.2_Missense_Mutation_p.T339M|RBM6_uc011bdi.1_Missense_Mutation_p.T203M|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	861					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AGAGGAGTGACGAGGGTAAGA	0.378												
SEMA3F	6405	broad.mit.edu	37	3	50211341	50211341	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:50211341C>T	uc003cyj.2	+	3	426	c.228C>T	c.(226-228)TAC>TAT	p.Y76Y	SEMA3F_uc003cyk.2_Silent_p.Y76Y	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	76	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		GCAAGGACTACGTGCTGTCCC	0.617												
RASSF1	11186	broad.mit.edu	37	3	50369011	50369011	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:50369011G>A	uc003dad.1	-	4	882	c.751C>T	c.(751-753)CGC>TGC	p.R251C	RASSF1_uc003daa.1_Missense_Mutation_p.R96C|RASSF1_uc003dab.1_Missense_Mutation_p.R177C|RASSF1_uc003dac.2_Missense_Mutation_p.R96C|RASSF1_uc003dae.1_Missense_Mutation_p.R247C|RASSF1_uc010hlk.1_RNA|RASSF1_uc003daf.1_Missense_Mutation_p.R96C	NM_170714	NP_733832	Q9NS23	RASF1_HUMAN	Ras association domain family 1 isoform D	251	Ras-associating.				cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CGCTCAGCGCGCTCAAAGAGT	0.607												
NISCH	11188	broad.mit.edu	37	3	52522196	52522196	+	Silent	SNP	G	G	A	rs113789685		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:52522196G>A	uc011beg.1	+	17	2760	c.2688G>A	c.(2686-2688)GCG>GCA	p.A896A	NISCH_uc003ded.3_Silent_p.A896A|NISCH_uc003dee.3_Silent_p.A385A|NISCH_uc003deg.1_RNA|NISCH_uc003deh.3_5'Flank	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	896					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CCTGCTGCGCGCCCTCTGAGG	0.657												
STAB1	23166	broad.mit.edu	37	3	52557277	52557277	+	Missense_Mutation	SNP	G	G	A	rs137992546		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:52557277G>A	uc003dej.2	+	64	7134	c.7060G>A	c.(7060-7062)GAC>AAC	p.D2354N	STAB1_uc003dek.1_Missense_Mutation_p.D369N|STAB1_uc003del.2_Missense_Mutation_p.D241N	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	2354	Extracellular (Potential).|FAS1 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCGGGGTCTCGACTTCCTGGA	0.567												
PBRM1	55193	broad.mit.edu	37	3	52595936	52595936	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:52595936G>A	uc003des.2	-	25	4147	c.4135C>T	c.(4135-4137)CGG>TGG	p.R1379W	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.R1379W|PBRM1_uc003der.2_Missense_Mutation_p.R1347W|PBRM1_uc003det.2_Missense_Mutation_p.R1394W|PBRM1_uc003deu.2_Missense_Mutation_p.R1394W|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.R1379W|PBRM1_uc010hmk.1_Missense_Mutation_p.R1354W|PBRM1_uc003dey.2_Missense_Mutation_p.R1327W|PBRM1_uc003dez.1_Missense_Mutation_p.R1378W	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1379	HMG box.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		TTGATTTTCCGTTTGGAGCCT	0.478			Mis|N|F|S|D|O		clear cell renal carcinoma|breast							
SFMBT1	51460	broad.mit.edu	37	3	52941285	52941285	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:52941285C>A	uc003dgf.2	-	20	2700	c.2131G>T	c.(2131-2133)GAT>TAT	p.D711Y	SFMBT1_uc010hmr.2_Missense_Mutation_p.D658Y|SFMBT1_uc003dgg.2_Missense_Mutation_p.D711Y|SFMBT1_uc003dgh.2_Missense_Mutation_p.D711Y	NM_001005159	NP_001005159	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	711					regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		CTTAGGGAATCATCATCCCCT	0.473												
CADPS	8618	broad.mit.edu	37	3	62477973	62477973	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:62477973C>T	uc003dll.2	-	20	3236	c.2876G>A	c.(2875-2877)CGT>CAT	p.R959H	CADPS_uc003dlk.1_Missense_Mutation_p.R456H|CADPS_uc003dlm.2_Missense_Mutation_p.R969H|CADPS_uc003dln.2_Missense_Mutation_p.R929H	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	959	MHD1.|Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ACAGTCAGTACGGAGAAAATC	0.428												
PDZRN3	23024	broad.mit.edu	37	3	73432742	73432742	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:73432742C>T	uc003dpl.1	-	10	3071	c.2975G>A	c.(2974-2976)CGC>CAC	p.R992H	PDZRN3_uc011bgh.1_Missense_Mutation_p.R649H|PDZRN3_uc010hoe.1_Missense_Mutation_p.R690H|PDZRN3_uc011bgf.1_Missense_Mutation_p.R709H|PDZRN3_uc011bgg.1_Missense_Mutation_p.R712H	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	992	Potential.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CATGAACTCGCGCCGCCGCCG	0.577												
PDZRN3	23024	broad.mit.edu	37	3	73432975	73432975	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:73432975C>T	uc003dpl.1	-	10	2838	c.2742G>A	c.(2740-2742)CCG>CCA	p.P914P	PDZRN3_uc011bgh.1_Silent_p.P571P|PDZRN3_uc010hoe.1_Silent_p.P612P|PDZRN3_uc011bgf.1_Silent_p.P631P|PDZRN3_uc011bgg.1_Silent_p.P634P	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	914							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCGGCTCCGACGGGGTGGGAG	0.657												
ROBO1	6091	broad.mit.edu	37	3	78685077	78685077	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:78685077G>A	uc003dqe.2	-	23	3427	c.3219C>T	c.(3217-3219)TAC>TAT	p.Y1073Y	ROBO1_uc003dqb.2_Silent_p.Y1034Y|ROBO1_uc003dqc.2_Silent_p.Y973Y|ROBO1_uc003dqd.2_Silent_p.Y1028Y|ROBO1_uc010hoh.2_Silent_p.Y265Y|ROBO1_uc011bgl.1_Silent_p.Y645Y	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1073	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GAGTGGTGGCGTAAGGAGTAG	0.488												
C3orf26	84319	broad.mit.edu	37	3	99890707	99890707	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:99890707C>T	uc003dtl.2	+	7	686	c.543C>T	c.(541-543)GAC>GAT	p.D181D		NM_032359	NP_115735	Q9BQ75	CC026_HUMAN	hypothetical protein LOC84319	181							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(1)	1						TCAGAGGAGACGGCAAAGTTA	0.418												
DPPA4	55211	broad.mit.edu	37	3	109050737	109050737	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:109050737T>C	uc003dxq.3	-	3	375	c.320A>G	c.(319-321)AAG>AGG	p.K107R	DPPA4_uc011bho.1_Missense_Mutation_p.K107R|DPPA4_uc011bhp.1_Missense_Mutation_p.K107R	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	107						nucleus	protein binding			upper_aerodigestive_tract(1)	1						GGAGCTCAGCTTCAATTGTTG	0.507												
GSK3B	2932	broad.mit.edu	37	3	119631658	119631658	+	Splice_Site	SNP	C	C	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:119631658C>G	uc003edo.2	-	6	1592	c.609_splice	c.e6-1	p.S203_splice	GSK3B_uc003edn.2_Splice_Site_p.S203_splice	NM_001146156	NP_001139628	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta isoform 2						axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			lung(2)	2				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	CTGCTTTGCACTAACAGAAAA	0.353												
POLQ	10721	broad.mit.edu	37	3	121230875	121230875	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:121230875G>A	uc003eee.3	-	10	1599	c.1470C>T	c.(1468-1470)GGC>GGT	p.G490G		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	490	Helicase C-terminal.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AGATACTCTCGCCTATAACCA	0.378								DNA_polymerases_(catalytic_subunits)				
WDR5B	54554	broad.mit.edu	37	3	122134419	122134419	+	Translation_Start_Site	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:122134419C>A	uc003efa.1	-	1	464	c.-43G>T	c.(-45--41)CAGGG>CATGG			NM_019069	NP_061942	Q86VZ2	WDR5B_HUMAN	WD repeat domain 5B											ovary(3)	3				GBM - Glioblastoma multiforme(114;0.0704)		GCGTTCAGCCCTGAACCAGGC	0.483												
ADCY5	111	broad.mit.edu	37	3	123051470	123051470	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:123051470C>T	uc003egh.1	-	4	1459	c.1459G>A	c.(1459-1461)GCA>ACA	p.A487T	ADCY5_uc003egg.1_Missense_Mutation_p.A120T|ADCY5_uc003egi.1_Missense_Mutation_p.A46T	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	487	Guanylate cyclase 1.|Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		AGTTCCTGTGCAGTGCACTGG	0.572												
MYLK	4638	broad.mit.edu	37	3	123427553	123427553	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:123427553G>A	uc003ego.2	-	15	2414	c.2132C>T	c.(2131-2133)ACG>ATG	p.T711M	MYLK_uc011bjw.1_Missense_Mutation_p.T711M|MYLK_uc003egp.2_Missense_Mutation_p.T642M|MYLK_uc003egq.2_Missense_Mutation_p.T711M|MYLK_uc003egr.2_Missense_Mutation_p.T642M|MYLK_uc003egs.2_Missense_Mutation_p.T535M	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	711	Ig-like C2-type 5.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACCTTGTACCGTGAGCACGGC	0.602												
ITGB5	3693	broad.mit.edu	37	3	124485139	124485139	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:124485139C>T	uc003eho.2	-	13	2368	c.2071G>A	c.(2071-2073)GTC>ATC	p.V691I	ITGB5_uc010hrx.2_RNA	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	691	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		AACATCATGACGCAGTCCTTG	0.572												
KLF15	28999	broad.mit.edu	37	3	126062587	126062587	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:126062587C>T	uc011bkk.1	-	3	1416	c.1234G>A	c.(1234-1236)GTG>ATG	p.V412M		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	412						nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		ACGGAGCGCACGGAGCGGCTG	0.592												
XRN1	54464	broad.mit.edu	37	3	142122802	142122802	+	Missense_Mutation	SNP	C	C	T	rs138660782		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:142122802C>T	uc003eus.2	-	17	1980	c.1913G>A	c.(1912-1914)CGT>CAT	p.R638H	XRN1_uc010huu.2_Missense_Mutation_p.R104H|XRN1_uc003eut.2_Missense_Mutation_p.R638H|XRN1_uc003euu.2_Missense_Mutation_p.R638H|XRN1_uc003euv.1_Missense_Mutation_p.R499H	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	638					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TATGTCTACACGCCAAGCATC	0.299												
PAQR9	344838	broad.mit.edu	37	3	142681763	142681763	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:142681763G>A	uc003evg.2	-	1	416	c.416C>T	c.(415-417)GCG>GTG	p.A139V	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	139	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GAACACGTGCGCCGTGCAGCT	0.657												
PLSCR1	5359	broad.mit.edu	37	3	146254325	146254325	+	Splice_Site	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:146254325A>C	uc003evx.3	-	2	401	c.13_splice	c.e2+1	p.N5_splice	PLSCR1_uc003evy.3_Intron|PLSCR1_uc011bnn.1_Splice_Site|PLSCR1_uc003evz.3_Splice_Site|PLSCR1_uc003ewa.2_Splice_Site_p.N5_splice	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1						phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						TAAATTACTTACTTTGTTTGT	0.294												
AADACL2	344752	broad.mit.edu	37	3	151458608	151458608	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:151458608C>T	uc003ezc.2	+	2	433	c.313C>T	c.(313-315)CGA>TGA	p.R105*	AADACL2_uc010hvn.2_Intron	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	105						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AACCCGAAGGCGAGCTGTGAT	0.368												
DHX36	170506	broad.mit.edu	37	3	154007599	154007599	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:154007599A>T	uc003ezy.3	-	16	1912	c.1831T>A	c.(1831-1833)TGC>AGC	p.C611S	DHX36_uc010hvq.2_Missense_Mutation_p.C597S|DHX36_uc003ezz.3_Missense_Mutation_p.C611S	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	611	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AGATGATAGCAATGACCAGGT	0.338												
PLCH1	23007	broad.mit.edu	37	3	155301426	155301426	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:155301426G>A	uc011bok.1	-	5	847	c.570C>T	c.(568-570)GCC>GCT	p.A190A	PLCH1_uc011boj.1_Silent_p.A190A|PLCH1_uc011bol.1_Silent_p.A172A	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	190	EF-hand 2.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CATCTGTGTCGGCTTCCTGAA	0.328												
RARRES1	5918	broad.mit.edu	37	3	158428614	158428614	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:158428614C>T	uc003fci.2	-	3	519	c.448G>A	c.(448-450)GAG>AAG	p.E150K	RARRES1_uc003fcj.2_Missense_Mutation_p.E150K	NM_206963	NP_996846	P49788	TIG1_HUMAN	retinoic acid receptor responder (tazarotene	150	Extracellular (Potential).				negative regulation of cell proliferation	integral to membrane					0			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)		Tretinoin(DB00755)	TTCTTTTTCTCGATGAGCCGT	0.423												
ZBBX	79740	broad.mit.edu	37	3	167077712	167077712	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:167077712T>G	uc003fep.2	-	8	701	c.378A>C	c.(376-378)AAA>AAC	p.K126N	ZBBX_uc011bpc.1_Missense_Mutation_p.K126N|ZBBX_uc003feq.2_Missense_Mutation_p.K97N	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	126						intracellular	zinc ion binding			ovary(2)	2						TTATCTTGGGTTTTTCACATT	0.303												
SLC7A14	57709	broad.mit.edu	37	3	170204127	170204127	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:170204127C>T	uc003fgz.2	-	5	1106	c.790G>A	c.(790-792)GCT>ACT	p.A264T	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	264	Helical; (Potential).					integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CCAATGAAAGCGTAGAAGCAT	0.517												
SLC7A14	57709	broad.mit.edu	37	3	170218991	170218991	+	Missense_Mutation	SNP	C	C	T	rs146405741		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:170218991C>T	uc003fgz.2	-	3	764	c.448G>A	c.(448-450)GGA>AGA	p.G150R	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	150						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GCACTGGCTCCGGCCGCAGTG	0.557												
MCCC1	56922	broad.mit.edu	37	3	182743546	182743546	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:182743546C>T	uc003fle.2	-	15	1865	c.1728G>A	c.(1726-1728)ATG>ATA	p.M576I	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_Intron|MCCC1_uc003flf.2_Missense_Mutation_p.M459I|MCCC1_uc003flg.2_Missense_Mutation_p.M467I|MCCC1_uc011bqp.1_Missense_Mutation_p.M529I	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	576					biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	GGCTTACCTGCATGCTATAAG	0.373												
AP2M1	1173	broad.mit.edu	37	3	183896808	183896808	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:183896808G>A	uc011bqx.1	+	3	395	c.238G>A	c.(238-240)GAA>AAA	p.E80K	AP2M1_uc003fmw.2_Missense_Mutation_p.E80K|AP2M1_uc003fmx.2_Missense_Mutation_p.E80K|AP2M1_uc003fmy.2_Missense_Mutation_p.E80K|AP2M1_uc011bqy.1_5'Flank|AP2M1_uc011bqz.1_5'Flank	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	80					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CATGGTCTTCGAATTCCTCTA	0.483												
THPO	7066	broad.mit.edu	37	3	184090371	184090371	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:184090371G>A	uc003fol.1	-	6	1207	c.992C>T	c.(991-993)ACG>ATG	p.T331M	THPO_uc003fom.1_Missense_Mutation_p.T327M|THPO_uc003fon.2_3'UTR|THPO_uc011bro.1_Missense_Mutation_p.T207M|THPO_uc003fop.2_3'UTR|THPO_uc011brp.1_Missense_Mutation_p.T144M	NM_000460	NP_000451	P40225	TPO_HUMAN	thrombopoietin precursor	331	Pro-rich.				cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			ovary(1)	1	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGGGTGGGCGTTGGAGCAGA	0.572												
IGF2BP2	10644	broad.mit.edu	37	3	185375140	185375140	+	Silent	SNP	G	G	A	rs142081639		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:185375140G>A	uc003fpo.2	-	12	1399	c.1320C>T	c.(1318-1320)GGC>GGT	p.G440G	IGF2BP2_uc010hyi.2_Silent_p.G383G|IGF2BP2_uc010hyj.2_Silent_p.G377G|IGF2BP2_uc010hyk.2_Silent_p.G304G|IGF2BP2_uc010hyl.2_Silent_p.G334G|IGF2BP2_uc003fpp.2_Silent_p.G397G|IGF2BP2_uc003fpq.2_Silent_p.G445G	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	440	KH 3.				anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			CGATGATGGCGCCCACAGCCT	0.567												
HRG	3273	broad.mit.edu	37	3	186395437	186395437	+	Missense_Mutation	SNP	G	G	A	rs149578094		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:186395437G>A	uc003fqq.2	+	7	1366	c.1343G>A	c.(1342-1344)CGT>CAT	p.R448H		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	448	His/Pro-rich (HRR).				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		AAAGGACCCCGTCCCTTCCAT	0.567												
LPP	4026	broad.mit.edu	37	3	188123957	188123957	+	Missense_Mutation	SNP	G	G	A	rs139718801	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:188123957G>A	uc003frs.1	+	3	295	c.49G>A	c.(49-51)GGC>AGC	p.G17S	LPP_uc011bsg.1_Missense_Mutation_p.G17S|LPP_uc011bsi.1_Missense_Mutation_p.G17S|LPP_uc003frt.2_Missense_Mutation_p.G17S	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	17					cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TGAGCCCCTCGGCCATGTGCC	0.502			T	HMGA2|MLL|C12orf9	lipoma|leukemia							
GP5	2814	broad.mit.edu	37	3	194118379	194118379	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:194118379C>T	uc003ftv.1	-	2	664	c.633G>A	c.(631-633)TCG>TCA	p.S211S		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	211	Extracellular (Potential).|LRR 6.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		TCAACAGCCCCGAATCCAGAG	0.612												
TNK2	10188	broad.mit.edu	37	3	195594978	195594978	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:195594978T>C	uc003fvu.1	-	12	2689	c.2146A>G	c.(2146-2148)AGG>GGG	p.R716G	TNK2_uc003fvq.1_Missense_Mutation_p.R123G|TNK2_uc003fvr.1_Missense_Mutation_p.R241G|TNK2_uc003fvs.1_Missense_Mutation_p.R748G|TNK2_uc003fvt.1_Missense_Mutation_p.R794G|TNK2_uc010hzw.1_RNA	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	716	Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TGCAGTTGCCTCATGCACTCC	0.716												
OSTalpha	200931	broad.mit.edu	37	3	195944785	195944785	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:195944785C>T	uc003fwd.2	+	2	312	c.111C>T	c.(109-111)CCC>CCT	p.P37P	OSTalpha_uc011btu.1_Silent_p.P37P	NM_152672	NP_689885	Q86UW1	OSTA_HUMAN	organic solute transporter alpha	37						integral to membrane|plasma membrane	transporter activity			ovary(1)	1	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;8.83e-25)|all cancers(36;8.38e-23)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;7.51e-07)|Lung(62;1.06e-06)	GBM - Glioblastoma multiforme(46;0.00202)		CTCAGCCTCCCACAGCAGCCC	0.607												
KIAA1530	57654	broad.mit.edu	37	4	1348916	1348916	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:1348916C>T	uc003gde.3	+	7	1506	c.1059C>T	c.(1057-1059)CGC>CGT	p.R353R		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	353											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			GCTTCACCCGCGTCGGGACCC	0.617												
TACC3	10460	broad.mit.edu	37	4	1742700	1742700	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:1742700A>T	uc003gdo.2	+	13	2318	c.2210A>T	c.(2209-2211)GAG>GTG	p.E737V	TACC3_uc003gdp.2_Missense_Mutation_p.E377V|TACC3_uc010ica.2_Missense_Mutation_p.E158V	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	737	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GAGGTGATCGAGGGCTACCGC	0.522												
ZFYVE28	57732	broad.mit.edu	37	4	2306791	2306791	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:2306791C>T	uc003gex.1	-	8	1595	c.1276G>A	c.(1276-1278)GCA>ACA	p.A426T	ZFYVE28_uc011bvk.1_Missense_Mutation_p.A356T|ZFYVE28_uc011bvl.1_Missense_Mutation_p.A396T|ZFYVE28_uc003gew.1_Missense_Mutation_p.A312T	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	426					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GTACTGCCTGCCCACCCAAAT	0.677												
TNIP2	79155	broad.mit.edu	37	4	2746454	2746454	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:2746454C>T	uc003gfg.2	-	4	963	c.876G>A	c.(874-876)GCG>GCA	p.A292A	TNIP2_uc003gff.2_Silent_p.A185A|TNIP2_uc003gfh.2_Intron	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	292	Potential.					cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCCGCTCCAACGCAGCATCCC	0.612												
NOP14	8602	broad.mit.edu	37	4	2948228	2948228	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:2948228C>T	uc003ggj.1	-	11	1618	c.1546G>A	c.(1546-1548)GCT>ACT	p.A516T	C4orf10_uc003gge.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.A262T|NOP14_uc003ggk.3_Missense_Mutation_p.A516T|NOP14_uc003ggl.2_Missense_Mutation_p.A516T	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	516					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						AATTTGATAGCGTCACTTGCA	0.438												
EVC2	132884	broad.mit.edu	37	4	5664926	5664926	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:5664926A>G	uc003gij.2	-	9	1107	c.1053T>C	c.(1051-1053)GCT>GCC	p.A351A	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Silent_p.A271A	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	351						integral to membrane				large_intestine(3)|ovary(2)	5						TCACGCCATCAGCTGAGGTGA	0.468												
EVC	2121	broad.mit.edu	37	4	5733277	5733277	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:5733277C>T	uc003gil.1	+	4	694	c.510C>T	c.(508-510)GAC>GAT	p.D170D	EVC_uc003gim.1_RNA	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	170					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				GTGAGAAGGACGACTGCAGCT	0.602												
CRMP1	1400	broad.mit.edu	37	4	5862758	5862758	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:5862758A>G	uc003gip.2	-	4	409	c.308T>C	c.(307-309)ATG>ACG	p.M103T	CRMP1_uc003gin.1_Intron|CRMP1_uc003giq.2_Missense_Mutation_p.M103T|CRMP1_uc003gir.2_Missense_Mutation_p.M98T|CRMP1_uc003gis.2_Missense_Mutation_p.M217T	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	103					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CTCACTGATCATCGTGGTCCC	0.577												
CCDC96	257236	broad.mit.edu	37	4	7043508	7043508	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:7043508C>A	uc003gjv.2	-	1	1221	c.1158G>T	c.(1156-1158)CTG>CTT	p.L386L	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	386	Potential.										0						CAAAATGCACCAGGCTCTGCT	0.522												
DRD5	1816	broad.mit.edu	37	4	9784659	9784659	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:9784659G>A	uc003gmb.3	+	1	1402	c.1006G>A	c.(1006-1008)GTC>ATC	p.V336I		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	336	Extracellular (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CTTCCCCTGCGTCAGTGAGAC	0.587												
SLC2A9	56606	broad.mit.edu	37	4	9987317	9987317	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:9987317G>A	uc003gmc.2	-	4	572	c.511C>T	c.(511-513)CGC>TGC	p.R171C	SLC2A9_uc003gmd.2_Missense_Mutation_p.R142C	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	171	Extracellular (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			ovary(3)	3						ATGATGAAGCGTCCCACGATG	0.388												
C1QTNF7	114905	broad.mit.edu	37	4	15444178	15444178	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:15444178G>A	uc011bxb.1	+	3	852	c.625G>A	c.(625-627)GGA>AGA	p.G209R	C1QTNF7_uc003gno.2_Missense_Mutation_p.G216R|C1QTNF7_uc003gnp.2_Missense_Mutation_p.G209R	NM_001135171	NP_001128643	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	209	C1q.					collagen					0						TCTGGCAATCGGACTGGTACA	0.478												
LGI2	55203	broad.mit.edu	37	4	25014047	25014047	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:25014047C>T	uc003grf.2	-	7	829	c.730G>A	c.(730-732)GTG>ATG	p.V244M		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	244	EAR 1.					extracellular region					0		Breast(46;0.173)				GCGATGGCCACGTACACATCG	0.468												
ZCCHC4	29063	broad.mit.edu	37	4	25334863	25334863	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:25334863C>T	uc003grl.3	+	4	424	c.388C>T	c.(388-390)CAG>TAG	p.Q130*	ZCCHC4_uc003grm.1_RNA|ZCCHC4_uc003grn.3_5'UTR	NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	130							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				AACATGTCAGCAGTTGTTGTT	0.388												
SLC34A2	10568	broad.mit.edu	37	4	25665888	25665888	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:25665888C>T	uc003grr.2	+	4	396	c.315C>T	c.(313-315)CTC>CTT	p.L105L	SLC34A2_uc003grs.2_Silent_p.L104L|SLC34A2_uc010iev.2_Silent_p.L104L	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	105	Helical; Name=M1; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				TTTTACTTCTCGGATTTCTCT	0.507												
CHRNA9	55584	broad.mit.edu	37	4	40356371	40356371	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:40356371C>T	uc003gva.1	+	5	1290	c.1274C>T	c.(1273-1275)ACG>ATG	p.T425M		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	425	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	AAAGTGCTGACGAGGAATATT	0.498												
BEND4	389206	broad.mit.edu	37	4	42119703	42119703	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:42119703C>T	uc003gwn.2	-	6	2017	c.1437G>A	c.(1435-1437)TCG>TCA	p.S479S	BEND4_uc003gwm.2_3'UTR	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	479	BEN.										0						TCTGCTCTTCCGAGGGCATCC	0.498												
FRYL	285527	broad.mit.edu	37	4	48569288	48569288	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:48569288G>A	uc003gyh.1	-	28	3751	c.3146C>T	c.(3145-3147)GCG>GTG	p.A1049V	FRYL_uc003gyk.2_Missense_Mutation_p.A1049V|FRYL_uc003gyi.1_5'Flank	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1049					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AATAATATTCGCCACTAAGGC	0.328												
LRRC66	339977	broad.mit.edu	37	4	52861190	52861190	+	Silent	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:52861190T>G	uc003gzi.2	-	4	2011	c.1998A>C	c.(1996-1998)CCA>CCC	p.P666P		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	666						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GAAAGACTGATGGGCCTGTGT	0.557												
GSX2	170825	broad.mit.edu	37	4	54966533	54966533	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:54966533G>A	uc010igp.1	+	1	286	c.22G>A	c.(22-24)GAC>AAC	p.D8N	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	8						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			CTTCTATGTCGACTCGCTCAT	0.647												
KIAA1211	57482	broad.mit.edu	37	4	57181853	57181853	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:57181853T>C	uc003hbk.2	+	8	2576	c.2185T>C	c.(2185-2187)TCC>CCC	p.S729P	KIAA1211_uc010iha.2_Missense_Mutation_p.S722P|KIAA1211_uc011bzz.1_Missense_Mutation_p.S639P|KIAA1211_uc003hbm.1_Missense_Mutation_p.S615P	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	729								p.S729S(1)		ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCAGAAATTTTCCGATGGTGG	0.572												
CSN3	1448	broad.mit.edu	37	4	71114781	71114781	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:71114781C>T	uc003hfe.3	+	4	212	c.154C>T	c.(154-156)CCA>TCA	p.P52S		NM_005212	NP_005203	P07498	CASK_HUMAN	casein kappa precursor	52						extracellular region	protein binding	p.P52A(1)		ovary(2)|kidney(1)|central_nervous_system(1)	4						GTATTATGTGCCAAATAGCTA	0.333												
C4orf35	85438	broad.mit.edu	37	4	71201047	71201047	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:71201047C>A	uc003hff.2	+	1	377	c.291C>A	c.(289-291)ACC>ACA	p.T97T		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	97						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				AAGAAATTACCTCTCTGACTG	0.373												
NAAA	27163	broad.mit.edu	37	4	76842177	76842177	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:76842177G>A	uc003hjb.2	-	6	830	c.766C>T	c.(766-768)CGG>TGG	p.R256W	NAAA_uc003hja.2_Missense_Mutation_p.R256W|NAAA_uc003hjc.3_Missense_Mutation_p.R256W|NAAA_uc003hjd.3_RNA|NAAA_uc011cbq.1_Missense_Mutation_p.R155W	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	256					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1						ACCCCCTCCCGGGGGGACGTG	0.512												
ANKRD56	345079	broad.mit.edu	37	4	77817102	77817102	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:77817102G>A	uc003hki.2	-	1	1901	c.1901C>T	c.(1900-1902)GCG>GTG	p.A634V		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	634	ANK 1.										0						CCAGTGCAACGCAGTGTACCC	0.522												
FRAS1	80144	broad.mit.edu	37	4	79371314	79371314	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:79371314C>T	uc003hlb.2	+	45	6724	c.6284C>T	c.(6283-6285)GCA>GTA	p.A2095V		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2094	CSPG 9.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GGGTCTGTAGCACGCATCACA	0.453												
PRDM8	56978	broad.mit.edu	37	4	81122567	81122567	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:81122567C>T	uc010ijo.2	+	7	1182	c.343C>T	c.(343-345)CGC>TGC	p.R115C	PRDM8_uc003hmb.3_Missense_Mutation_p.R115C|PRDM8_uc003hmc.3_Missense_Mutation_p.R115C	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	115	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						GCTGTTCTACCGCTCTCTCCG	0.498												
BMP3	651	broad.mit.edu	37	4	81952623	81952623	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:81952623G>A	uc003hmg.3	+	1	505	c.185G>A	c.(184-186)CGG>CAG	p.R62Q		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	62					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						CACATGCTGCGGCTCTATGAC	0.687												
SLC10A6	345274	broad.mit.edu	37	4	87754575	87754575	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:87754575A>G	uc003hqd.2	-	2	528	c.380T>C	c.(379-381)ATC>ACC	p.I127T		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	127	Cytoplasmic (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		TGTCATACTGATGCTGAAAGT	0.438												
KLHL8	57563	broad.mit.edu	37	4	88091757	88091757	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:88091757C>T	uc011cdb.1	-	7	1604	c.1219G>A	c.(1219-1221)GCC>ACC	p.A407T	KLHL8_uc003hql.1_Missense_Mutation_p.A407T|KLHL8_uc003hqm.1_Missense_Mutation_p.A331T|KLHL8_uc003hqn.1_Missense_Mutation_p.A224T|KLHL8_uc010ikj.1_Missense_Mutation_p.A56T	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	407	Kelch 2.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		GAAGCCAAGGCAATTCCTCGC	0.358												
HERC5	51191	broad.mit.edu	37	4	89388315	89388315	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:89388315G>A	uc003hrt.2	+	7	1170	c.1017G>A	c.(1015-1017)CCG>CCA	p.P339P	HERC5_uc011cdm.1_5'Flank	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	339	RCC1 5.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		AGCTGATGCCGCTTCCAGTGA	0.393												
PDHA2	5161	broad.mit.edu	37	4	96761964	96761964	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:96761964G>T	uc003htr.3	+	1	726	c.663G>T	c.(661-663)GAG>GAT	p.E221D		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	221					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TCATCTGTGAGAATAACCTAT	0.453												
TSPAN5	10098	broad.mit.edu	37	4	99397385	99397385	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:99397385A>T	uc003hub.2	-	7	1046	c.696T>A	c.(694-696)AAT>AAA	p.N232K	TSPAN5_uc011cdz.1_Missense_Mutation_p.N161K	NM_005723	NP_005714	P62079	TSN5_HUMAN	transmembrane 4 superfamily member 9	232	Extracellular (Potential).					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;1.89e-07)		CGATGGTTAAATTGTCCTGCA	0.458												
CASP6	839	broad.mit.edu	37	4	110618908	110618908	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:110618908C>T	uc003hzn.1	-	3	178	c.100G>A	c.(100-102)GCA>ACA	p.A34T	CASP6_uc003hzo.1_Intron	NM_001226	NP_001217	P55212	CASP6_HUMAN	caspase 6 isoform alpha preproprotein	34					cellular component disassembly involved in apoptosis|induction of apoptosis|proteolysis	cytosol|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)|breast(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000171)		TACTTTTCTGCCGGATCAAAC	0.398												
RRH	10692	broad.mit.edu	37	4	110757242	110757242	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:110757242T>C	uc003hzv.2	+	4	511	c.477T>C	c.(475-477)CCT>CCC	p.P159P		NM_006583	NP_006574	O14718	OPSX_HUMAN	peropsin	159	Helical; Name=4; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		CTTTGATGCCTATCATAGGGT	0.438												
AP1AR	55435	broad.mit.edu	37	4	113189356	113189356	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:113189356C>T	uc003iaj.3	+	10	1053	c.700C>T	c.(700-702)CGG>TGG	p.R234W	AP1AR_uc003iak.3_Missense_Mutation_p.R201W	NM_018569	NP_061039	Q63HQ0	AP1AR_HUMAN	adaptor-related protein complex 1 associated	234					protein transport	early endosome|Golgi apparatus|late endosome|transport vesicle					0						AGACATTCTACGGGCAGCACT	0.388												
C4orf21	55345	broad.mit.edu	37	4	113462250	113462250	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:113462250G>C	uc003iau.2	-	25	5984	c.5773C>G	c.(5773-5775)CAG>GAG	p.Q1925E	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.Q383E	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	747						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TCATTTACCTGTTCTAGTCCT	0.363												
KIAA1109	84162	broad.mit.edu	37	4	123120560	123120560	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:123120560T>C	uc003ieh.2	+	12	1380	c.1335T>C	c.(1333-1335)ACT>ACC	p.T445T	KIAA1109_uc003iei.1_Silent_p.T199T|KIAA1109_uc010ins.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	445					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGGATGCCACTACCAGCATGC	0.328												
FAT4	79633	broad.mit.edu	37	4	126238642	126238642	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:126238642C>T	uc003ifj.3	+	1	1076	c.1076C>T	c.(1075-1077)CCG>CTG	p.P359L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	359	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CGCTACTTCCCGGCCACCTCG	0.632											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
KLHL2	11275	broad.mit.edu	37	4	166238981	166238981	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:166238981T>G	uc003irb.2	+	14	1872	c.1613T>G	c.(1612-1614)GTT>GGT	p.V538G	KLHL2_uc011cjm.1_Missense_Mutation_p.V542G|KLHL2_uc003irc.2_Missense_Mutation_p.V450G|KLHL2_uc010ira.2_Missense_Mutation_p.V191G	NM_007246	NP_009177	O95198	KLHL2_HUMAN	kelch-like 2, Mayven isoform 1	538	Kelch 5.				intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity				0	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		TTTAAAGGAGTTTGTGCAGTT	0.343												
SPOCK3	50859	broad.mit.edu	37	4	167675677	167675677	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:167675677A>C	uc003iri.1	-	9	1063	c.922T>G	c.(922-924)TGC>GGC	p.C308G	SPOCK3_uc011cjp.1_Missense_Mutation_p.C265G|SPOCK3_uc011cjq.1_Missense_Mutation_p.C317G|SPOCK3_uc011cjr.1_Missense_Mutation_p.C188G|SPOCK3_uc003irj.1_Missense_Mutation_p.C305G|SPOCK3_uc011cjs.1_Missense_Mutation_p.C257G|SPOCK3_uc011cjt.1_Missense_Mutation_p.C216G|SPOCK3_uc011cju.1_Missense_Mutation_p.C201G|SPOCK3_uc011cjv.1_Missense_Mutation_p.C210G|SPOCK3_uc003irk.3_Missense_Mutation_p.C305G	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	308					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		CTCTGGAAGCAGTAGCACCAC	0.348												
DDX60	55601	broad.mit.edu	37	4	169190007	169190007	+	Silent	SNP	G	G	A	rs145361158		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:169190007G>A	uc003irp.2	-	20	3076	c.2784C>T	c.(2782-2784)ACC>ACT	p.T928T		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	928	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		ATGCCTACTCGGTGAGATGTT	0.368												
PALLD	23022	broad.mit.edu	37	4	169812119	169812119	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:169812119G>T	uc011cjx.1	+	11	2222	c.2011G>T	c.(2011-2013)GAG>TAG	p.E671*	CBR4_uc011cjy.1_Intron|PALLD_uc003iru.2_Nonsense_Mutation_p.E671*|PALLD_uc003irv.2_Nonsense_Mutation_p.E289*|PALLD_uc003irw.2_Nonsense_Mutation_p.E173*	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	895					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		AGCCTCCGATGAGGAAATTCA	0.443									Pancreatic_Cancer_Familial_Clustering_of			
NEK1	4750	broad.mit.edu	37	4	170345785	170345785	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:170345785C>T	uc003isb.1	-	29	3549	c.3057G>A	c.(3055-3057)TCG>TCA	p.S1019S	NEK1_uc003isc.1_Silent_p.S975S|NEK1_uc003isd.1_Silent_p.S1047S|NEK1_uc003ise.1_Silent_p.S1003S|NEK1_uc003isf.1_Silent_p.S950S	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1019					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		GTGGTAAATGCGAGTGAGATC	0.393												
FBXO8	26269	broad.mit.edu	37	4	175183955	175183955	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:175183955C>T	uc003itp.2	-	2	1139	c.289G>A	c.(289-291)GTT>ATT	p.V97I	FBXO8_uc003itq.2_Intron	NM_012180	NP_036312	Q9NRD0	FBX8_HUMAN	F-box only protein 8	97	F-box.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(2)	2		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		TCCTGCCAAACACATGAAGCC	0.413												
ODZ3	55714	broad.mit.edu	37	4	183600990	183600990	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:183600990A>G	uc003ivd.1	+	7	1535	c.1498A>G	c.(1498-1500)AAA>GAA	p.K500E	ODZ3_uc003ive.1_5'Flank	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	500	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TAATGATGGGAAAAATGCAGA	0.448												
IRF2	3660	broad.mit.edu	37	4	185339687	185339687	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:185339687T>C	uc003iwf.3	-	4	563	c.363A>G	c.(361-363)AAA>AAG	p.K121K		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	121					blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		TGCCTTTACCTTTCTTAGAAG	0.398												
MTNR1A	4543	broad.mit.edu	37	4	187455100	187455100	+	Missense_Mutation	SNP	C	C	T	rs148793802		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:187455100C>T	uc003izd.1	-	2	814	c.796G>A	c.(796-798)GCC>ACC	p.A266T		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	266	Extracellular (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	ACCATGCTGGCGGGGTCAGAG	0.507												
SLC9A3	6550	broad.mit.edu	37	5	488455	488455	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:488455C>T	uc003jbe.2	-	3	763	c.651G>A	c.(649-651)TCG>TCA	p.S217S	SLC9A3_uc011clx.1_Silent_p.S217S	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	217	Helical; Name=G/M5B; (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CGTTCAGCAGCGACTCCCCGA	0.667												
LPCAT1	79888	broad.mit.edu	37	5	1466903	1466903	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:1466903G>A	uc003jcm.2	-	13	1498	c.1381C>T	c.(1381-1383)CGA>TGA	p.R461*	LPCAT1_uc003jcl.2_Nonsense_Mutation_p.R35*	NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	461	Lumenal (Potential).|EF-hand 2.				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TCAATGGCTCGGAATAGGTCG	0.647												
IRX4	50805	broad.mit.edu	37	5	1878859	1878859	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:1878859C>T	uc003jcz.2	-	5	903	c.784G>A	c.(784-786)GAC>AAC	p.D262N	IRX4_uc011cmf.1_Missense_Mutation_p.D123N	NM_016358	NP_057442	P78413	IRX4_HUMAN	iroquois homeobox 4	262					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(108;0.242)		GGGTCGAAGTCGTCCAAGTCA	0.672												
C5orf38	153571	broad.mit.edu	37	5	2752844	2752844	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:2752844G>A	uc003jdc.2	+	2	426	c.309G>A	c.(307-309)GCG>GCA	p.A103A	C5orf38_uc011cmg.1_Silent_p.A103A|C5orf38_uc011cmh.1_RNA|C5orf38_uc011cmi.1_RNA|C5orf38_uc011cmj.1_Intron	NM_178569	NP_848664	Q86SI9	CEI_HUMAN	hypothetical protein LOC153571 precursor	103						extracellular region					0				GBM - Glioblastoma multiforme(108;0.205)		TCAGGTTGGCGCCGCCGGTGC	0.642												
ADCY2	108	broad.mit.edu	37	5	7709334	7709334	+	Missense_Mutation	SNP	G	G	A	rs141886153	by1000genomes	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:7709334G>A	uc003jdz.1	+	10	1479	c.1412G>A	c.(1411-1413)CGG>CAG	p.R471Q	ADCY2_uc011cmo.1_Missense_Mutation_p.R291Q	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	471	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGAGAACGACGGAGCCCCCAG	0.587												
ANKH	56172	broad.mit.edu	37	5	14769138	14769138	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:14769138C>T	uc003jfm.3	-	2	590	c.259G>A	c.(259-261)GTC>ATC	p.V87I		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	87	Helical; (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						ATACACAGGACGGCTTTGGTC	0.547												
MTMR12	54545	broad.mit.edu	37	5	32230244	32230244	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:32230244T>C	uc003jhq.2	-	16	2054	c.1884A>G	c.(1882-1884)TTA>TTG	p.L628L	MTMR12_uc010iuk.2_Silent_p.L574L|MTMR12_uc010iul.2_Silent_p.L518L	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	628	Myotubularin phosphatase.					cytoplasm	phosphatase activity			ovary(1)	1						CGATATGCGGTAACAACAAAC	0.488												
ZFR	51663	broad.mit.edu	37	5	32404048	32404048	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:32404048G>A	uc003jhr.1	-	7	1267	c.1187C>T	c.(1186-1188)GCG>GTG	p.A396V		NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	396					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		GGCAGCATACGCATCTGCTCC	0.448												
RAI14	26064	broad.mit.edu	37	5	34824014	34824014	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:34824014C>T	uc003jir.2	+	15	2263	c.2067C>T	c.(2065-2067)AAC>AAT	p.N689N	RAI14_uc010iur.2_Silent_p.N660N|RAI14_uc011coj.1_Silent_p.N689N|RAI14_uc003jis.2_Silent_p.N692N|RAI14_uc003jit.2_Silent_p.N689N|RAI14_uc011cok.1_Silent_p.N681N	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	689	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					AATTGACAAACGTGTCCAGGG	0.438												
HEATR7B2	133558	broad.mit.edu	37	5	41009422	41009422	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:41009422G>A	uc003jmj.3	-	32	3870	c.3380C>T	c.(3379-3381)ACT>ATT	p.T1127I	HEATR7B2_uc003jmi.3_Missense_Mutation_p.T682I	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1127	HEAT 12.						binding			ovary(6)|central_nervous_system(2)	8						TTCTAACTCAGTCTCCAGTTT	0.498												
C6	729	broad.mit.edu	37	5	41203323	41203323	+	Missense_Mutation	SNP	G	G	A	rs150931891	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:41203323G>A	uc003jmk.2	-	2	220	c.10C>T	c.(10-12)CGC>TGC	p.R4C	C6_uc003jml.1_Missense_Mutation_p.R4C	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	4					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AAGACAGAGCGTCTGGCCATG	0.463												
MGC42105	167359	broad.mit.edu	37	5	43280635	43280635	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:43280635G>A	uc003jno.2	+	4	1996	c.1115G>A	c.(1114-1116)CGA>CAA	p.R372Q		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	372							ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.R372*(2)		lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						GAGCATATTCGAAATAACCAA	0.423												
PELO	53918	broad.mit.edu	37	5	52096812	52096812	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:52096812G>A	uc003jos.2	+	2	1569	c.584G>A	c.(583-585)CGC>CAC	p.R195H	ITGA1_uc003jov.2_Intron|ITGA1_uc003jou.2_Intron|PELO_uc003jot.1_Intron	NM_015946	NP_057030	Q9BRX2	PELO_HUMAN	pelota homolog	195					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding				0		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				GCTATCCAGCGCCACATACAC	0.522												
HTR1A	3350	broad.mit.edu	37	5	63256991	63256991	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:63256991C>T	uc011cqt.1	-	1	556	c.556G>A	c.(556-558)GCA>ACA	p.A186T		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	186	Extracellular (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ATGGTGCATGCGTCGGGGTCC	0.572												
SFRS12	140890	broad.mit.edu	37	5	65473381	65473381	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:65473381C>T	uc003juo.2	+	12	1932	c.1272C>T	c.(1270-1272)GAC>GAT	p.D424D	SFRS12_uc003jun.2_Silent_p.D540D|SFRS12_uc010iwy.2_Silent_p.D423D	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	424	Arg/Glu/Lys/Ser-rich.				mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)		AAGAAAGGGACCACATCAGTG	0.333												
ZNF366	167465	broad.mit.edu	37	5	71756348	71756348	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:71756348G>A	uc003kce.1	-	2	1162	c.976C>T	c.(976-978)CGC>TGC	p.R326C		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	326	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		ATCATGTGGCGCTTCAGGTGG	0.657												
FCHO2	115548	broad.mit.edu	37	5	72377779	72377779	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:72377779C>T	uc003kcl.2	+	23	2266	c.2150C>T	c.(2149-2151)ACG>ATG	p.T717M	FCHO2_uc011csl.1_Missense_Mutation_p.T684M|FCHO2_uc010izb.2_Missense_Mutation_p.T145M|FCHO2_uc011csn.1_Missense_Mutation_p.T145M	NM_138782	NP_620137	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2 isoform a	717										ovary(1)	1		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		GGAGGAGTAACGAACATGCAG	0.423												
UTP15	84135	broad.mit.edu	37	5	72868406	72868406	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:72868406C>T	uc003kcw.1	+	7	989	c.766C>T	c.(766-768)CTA>TTA	p.L256L	UTP15_uc011cso.1_Silent_p.L237L|UTP15_uc011csp.1_Silent_p.L66L|UTP15_uc010ize.1_Silent_p.L256L	NM_032175	NP_115551	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein,	256	WD 6.				rRNA processing	cytoplasm|nucleolus					0		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		ATGTTTATGTCTAAGCAGCTC	0.353												
HOMER1	9456	broad.mit.edu	37	5	78697766	78697766	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:78697766G>A	uc003kfy.2	-	6	1743	c.640C>T	c.(640-642)CAA>TAA	p.Q214*	HOMER1_uc010jab.2_Intron|HOMER1_uc010jac.2_Intron|HOMER1_uc010jad.2_Nonsense_Mutation_p.Q40*	NM_004272	NP_004263	Q86YM7	HOME1_HUMAN	homer 1	214	Potential.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane					0		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		GCAGCAAGTTGCTGTTTCCAT	0.478												
ACOT12	134526	broad.mit.edu	37	5	80667576	80667576	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:80667576C>T	uc003khl.3	-	3	306	c.251G>A	c.(250-252)AGC>AAC	p.S84N	RNU5E_uc011cto.1_Intron|ACOT12_uc003khm.2_Missense_Mutation_p.S84N	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	84	Coenzyme A binding.|Acyl coenzyme A hydrolase 1.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TACCTCCATGCTTGTGCTGAA	0.398												
GPR98	84059	broad.mit.edu	37	5	89923028	89923028	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:89923028G>A	uc003kju.2	+	7	769	c.673G>A	c.(673-675)GTA>ATA	p.V225I	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	225	Calx-beta 2.|Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCTTTAACAGGTACCAGAAAA	0.318												
GPR98	84059	broad.mit.edu	37	5	90015894	90015894	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:90015894G>A	uc003kju.2	+	44	9573	c.9477G>A	c.(9475-9477)ACG>ACA	p.T3159T	GPR98_uc003kjt.2_Silent_p.T865T|GPR98_uc003kjv.2_Silent_p.T759T	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3159	Extracellular (Potential).|Calx-beta 22.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATTAGACACGGAACCAGAAA	0.363												
NR2F1	7025	broad.mit.edu	37	5	92923762	92923762	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:92923762G>A	uc003kkj.2	+	2	2290	c.603G>A	c.(601-603)TCG>TCA	p.S201S		NM_005654	NP_005645	P10589	COT1_HUMAN	nuclear receptor subfamily 2, group F, member 1	201					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			urinary_tract(1)|ovary(1)|lung(1)	3		all_cancers(142;1.62e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0126)|Lung NSC(167;0.0155)|Ovarian(174;0.0218)|Prostate(281;0.173)|Colorectal(57;0.19)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0416)|all cancers(79;9.57e-18)		ACCCCACGTCGCGCTACGGCA	0.667												
AQPEP	206338	broad.mit.edu	37	5	115299005	115299005	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:115299005C>T	uc003kro.2	+	1	855	c.691C>T	c.(691-693)CGC>TGC	p.R231C	AQPEP_uc003krp.2_RNA|uc003krn.1_5'Flank	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	231	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						CCAGGGCGAGCGCAGGTAAGG	0.672												
SNCAIP	9627	broad.mit.edu	37	5	121776408	121776408	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:121776408G>A	uc003ksw.1	+	7	1587	c.1381G>A	c.(1381-1383)GTT>ATT	p.V461I	SNCAIP_uc011cwl.1_Missense_Mutation_p.V19I|SNCAIP_uc010jct.2_Missense_Mutation_p.V461I|SNCAIP_uc003ksx.1_Missense_Mutation_p.V508I|SNCAIP_uc003ksy.1_Missense_Mutation_p.V95I|SNCAIP_uc003ksz.1_Missense_Mutation_p.V95I|SNCAIP_uc010jcu.2_Missense_Mutation_p.V57I|SNCAIP_uc011cwm.1_Missense_Mutation_p.V95I|SNCAIP_uc003kta.1_Missense_Mutation_p.V93I|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.V155I|SNCAIP_uc010jcx.1_Missense_Mutation_p.V401I|uc003ktb.1_Intron	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	461	ANK 4.				cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CAACAGTGCCGTTCACGTAGC	0.428												
ZNF608	57507	broad.mit.edu	37	5	123984642	123984642	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:123984642G>A	uc003ktq.1	-	4	1558	c.1435C>T	c.(1435-1437)CGA>TGA	p.R479*	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Nonsense_Mutation_p.R479*|ZNF608_uc003ktt.1_Nonsense_Mutation_p.R479*	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	479						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GGTGTCCTTCGTCCGCTGGCA	0.577												
PRRC1	133619	broad.mit.edu	37	5	126874760	126874760	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:126874760G>A	uc003kuk.2	+	7	1130	c.950G>A	c.(949-951)CGT>CAT	p.R317H	PRRC1_uc003kuj.3_Missense_Mutation_p.R317H	NM_130809	NP_570721	Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	317						Golgi apparatus					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		GATAGCTTGCGTCGAACTGGG	0.373												
P4HA2	8974	broad.mit.edu	37	5	131543466	131543466	+	Missense_Mutation	SNP	C	C	T	rs148040234		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:131543466C>T	uc003kwh.2	-	8	1579	c.1015G>A	c.(1015-1017)GTC>ATC	p.V339I	P4HA2_uc003kwg.2_Missense_Mutation_p.V339I|P4HA2_uc003kwi.2_Missense_Mutation_p.V339I|P4HA2_uc003kwk.2_Missense_Mutation_p.V339I|P4HA2_uc003kwl.2_Missense_Mutation_p.V339I|P4HA2_uc003kwj.2_Missense_Mutation_p.V339I	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	339						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	TAGTACCTGACGATGTGCGGG	0.527												
PDLIM4	8572	broad.mit.edu	37	5	131606656	131606656	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:131606656C>T	uc003kwn.2	+	4	453	c.376C>T	c.(376-378)CCA>TCA	p.P126S	uc003kwm.3_Intron|PDLIM4_uc003kwp.2_Missense_Mutation_p.P126S|PDLIM4_uc003kwo.2_Missense_Mutation_p.P126S	NM_003687	NP_003678	P50479	PDLI4_HUMAN	PDZ and LIM domain 4 isoform 1	126							protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CGGGACTGGGCCAGAAGATGG	0.627												
RAD50	10111	broad.mit.edu	37	5	131953826	131953826	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:131953826C>T	uc003kxi.2	+	21	3616	c.3229C>T	c.(3229-3231)CGA>TGA	p.R1077*	RAD50_uc003kxh.2_Nonsense_Mutation_p.R938*	NM_005732	NP_005723	Q92878	RAD50_HUMAN	RAD50 homolog isoform 1	1077	Potential.				DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGCATTAGGGCGACAGAAAGG	0.318								Homologous_recombination				
TRPC7	57113	broad.mit.edu	37	5	135692750	135692750	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:135692750G>A	uc003lbn.1	-	1	326	c.323C>T	c.(322-324)GCG>GTG	p.A108V	TRPC7_uc010jef.1_Missense_Mutation_p.A100V|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.A100V|TRPC7_uc010jei.1_Missense_Mutation_p.A100V|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	109	Cytoplasmic (Potential).|ANK 3.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CAGCAGCAGCGCGTCCCCCAC	0.667												
FAM13B	51306	broad.mit.edu	37	5	137278577	137278577	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:137278577G>A	uc003lbz.2	-	21	3043	c.2509C>T	c.(2509-2511)CGA>TGA	p.R837*	FAM13B_uc003lcb.2_Nonsense_Mutation_p.R713*|FAM13B_uc003lca.2_Nonsense_Mutation_p.R809*	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	837					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						GAAGCTGCTCGAGAACTTGAC	0.328												
FAM13B	51306	broad.mit.edu	37	5	137289904	137289904	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:137289904G>A	uc003lbz.2	-	14	2137	c.1603C>T	c.(1603-1605)CAT>TAT	p.H535Y	FAM13B_uc003lcb.2_Missense_Mutation_p.H439Y|FAM13B_uc003lca.2_Missense_Mutation_p.H535Y	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	535					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						TCTGGATCATGTAGGAAACGC	0.403												
WNT8A	7478	broad.mit.edu	37	5	137420203	137420203	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:137420203C>T	uc003lcd.1	+	3	124	c.119C>T	c.(118-120)ACG>ATG	p.T40M	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Missense_Mutation_p.T58M|WNT8A_uc011cyk.1_Missense_Mutation_p.T58M	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	40					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTGACCTACACGACTAGTGTG	0.577												
NRG2	9542	broad.mit.edu	37	5	139251390	139251390	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:139251390C>T	uc003lex.1	-	4	1253	c.1028G>A	c.(1027-1029)CGG>CAG	p.R343Q	NRG2_uc003lev.1_Missense_Mutation_p.R343Q|NRG2_uc003lew.1_Missense_Mutation_p.R343Q|NRG2_uc003ley.1_Missense_Mutation_p.R343Q	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	343	EGF-like.|Extracellular (Potential).				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTGCACTTCCGGGCGTGCCC	0.567												
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139905920	139905920	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:139905920G>C	uc003lfs.1	+	26	4956	c.4832G>C	c.(4831-4833)AGC>ACC	p.S1611T	ANKHD1_uc003lfr.2_Missense_Mutation_p.S1611T|ANKHD1_uc003lfu.1_Missense_Mutation_p.S1091T|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S350T|ANKHD1_uc003lfw.2_Missense_Mutation_p.S249T|ANKHD1_uc010jfl.2_Missense_Mutation_p.S46T|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1611						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGTAAAAGCCAAGAGTTA	0.428												
PCDHA1	56147	broad.mit.edu	37	5	140166534	140166534	+	Missense_Mutation	SNP	C	C	T	rs149577981	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140166534C>T	uc003lhb.2	+	1	659	c.659C>T	c.(658-660)CCG>CTG	p.P220L	PCDHA1_uc003lha.2_Missense_Mutation_p.P220L|PCDHA1_uc003lgz.2_Missense_Mutation_p.P220L	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	220	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGGCAAACCGGAGCTGCAA	0.458												
PCDHA1	56147	broad.mit.edu	37	5	140167731	140167731	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140167731G>A	uc003lhb.2	+	1	1856	c.1856G>A	c.(1855-1857)CGC>CAC	p.R619H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.R619H	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	619	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGCGCGCGCATCCCGTTC	0.667												
PCDHA3	56145	broad.mit.edu	37	5	140182842	140182842	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140182842C>T	uc003lhf.2	+	1	2060	c.2060C>T	c.(2059-2061)ACG>ATG	p.T687M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.T687M	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	687	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGCGCCACGGGCCCGGAA	0.632												
PCDHA5	56143	broad.mit.edu	37	5	140202765	140202765	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140202765C>A	uc003lhl.2	+	1	1405	c.1405C>A	c.(1405-1407)CCA>ACA	p.P469T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.P469T|PCDHA5_uc003lhj.1_Missense_Mutation_p.P469T	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	469	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACAACCCGCCAGGCTGCCA	0.677												
PCDHA6	56142	broad.mit.edu	37	5	140209889	140209889	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140209889C>T	uc003lho.2	+	1	2240	c.2213C>T	c.(2212-2214)ACG>ATG	p.T738M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.T738M	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	738	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAAGCCCACGCTGGTGTGC	0.692												
PCDHA7	56141	broad.mit.edu	37	5	140215576	140215576	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140215576C>T	uc003lhq.2	+	1	1608	c.1608C>T	c.(1606-1608)AGC>AGT	p.S536S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.S536S	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	536	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAGGTGAGCGCGCGCGATG	0.682												
PCDHA13	56136	broad.mit.edu	37	5	140263515	140263515	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140263515C>T	uc003lif.2	+	1	1662	c.1662C>T	c.(1660-1662)TTC>TTT	p.F554F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.F554F|PCDHA13_uc003lid.2_Silent_p.F554F	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	554	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGGTGTTCGTGCTGGACG	0.692												
PCDHA13	56136	broad.mit.edu	37	5	140264043	140264043	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140264043C>T	uc003lif.2	+	1	2190	c.2190C>T	c.(2188-2190)GGC>GGT	p.G730G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.G730G|PCDHA13_uc003lid.2_Silent_p.G730G	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	730	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCGAGGGCGCGTGCGCGC	0.662												
PCDHAC1	56135	broad.mit.edu	37	5	140306840	140306840	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140306840A>G	uc003lih.2	+	1	539	c.363A>G	c.(361-363)TCA>TCG	p.S121S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Silent_p.S121S	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	121	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAACTCACCTCTCTTTC	0.607												
PCDHB7	56129	broad.mit.edu	37	5	140553146	140553146	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140553146C>T	uc003lit.2	+	1	904	c.730C>T	c.(730-732)CGG>TGG	p.R244W		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	244	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGATTTTGTGCGGTCGCTCTA	0.542												
PCDHB7	56129	broad.mit.edu	37	5	140554034	140554034	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140554034G>A	uc003lit.2	+	1	1792	c.1618G>A	c.(1618-1620)GCG>ACG	p.A540T		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	540	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCTCCCCCGCGCTGAGCAG	0.697												
PCDHB16	57717	broad.mit.edu	37	5	140564007	140564007	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140564007C>T	uc003liv.2	+	1	3028	c.1873C>T	c.(1873-1875)CGC>TGC	p.R625C	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	625	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGCGAGGTGCGCACCGCCAG	0.697												
PCDHB9	56127	broad.mit.edu	37	5	140568534	140568534	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140568534G>A	uc003liw.1	+	3	1643	c.1643G>A	c.(1642-1644)CGC>CAC	p.R548H		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	548	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGCTGGTGCGCGTACTGGTG	0.711												
PCDHGA2	56113	broad.mit.edu	37	5	140719254	140719254	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140719254C>T	uc003ljk.1	+	1	901	c.716C>T	c.(715-717)GCG>GTG	p.A239V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.A239V	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	239	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGACAATGCGCCTGTTTTT	0.592												
PCDHGB4	8641	broad.mit.edu	37	5	140768432	140768432	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:140768432G>A	uc003lkc.1	+	1	981	c.981G>A	c.(979-981)GCG>GCA	p.A327A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.A327A	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	327	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAATGATTGCGCAATGCACAG	0.428												
ARHGAP26	23092	broad.mit.edu	37	5	142437258	142437258	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:142437258G>A	uc011dbj.1	+	17	1519	c.1484G>A	c.(1483-1485)CGG>CAG	p.R495Q	ARHGAP26_uc003lmt.2_Missense_Mutation_p.R495Q|ARHGAP26_uc003lmw.2_Missense_Mutation_p.R495Q	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	495	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTGTTCATCGGCTCCCAGAG	0.453												
ARHGAP26	23092	broad.mit.edu	37	5	142513670	142513670	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:142513670C>T	uc011dbj.1	+	19	1872	c.1837C>T	c.(1837-1839)CAG>TAG	p.Q613*	ARHGAP26_uc003lmt.2_Nonsense_Mutation_p.Q613*|ARHGAP26_uc003lmw.2_Nonsense_Mutation_p.Q613*	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	613	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACAGAGAAACGTGAGTCTTT	0.582												
SH3RF2	153769	broad.mit.edu	37	5	145393517	145393517	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:145393517C>T	uc003lnt.2	+	5	1190	c.952C>T	c.(952-954)CGC>TGC	p.R318C	SH3RF2_uc011dbl.1_Missense_Mutation_p.R318C	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	318							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCTTCAGGGCGCCATATGGT	0.577												
DPYSL3	1809	broad.mit.edu	37	5	146778698	146778698	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:146778698C>T	uc003lon.1	-	11	1338	c.1228G>A	c.(1228-1230)GTC>ATC	p.V410I	DPYSL3_uc003loo.2_Missense_Mutation_p.V524I	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	410					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCAGATGACGAGGTCGCTG	0.527												
ABLIM3	22885	broad.mit.edu	37	5	148577904	148577904	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:148577904G>A	uc003lpy.2	+	4	525	c.274G>A	c.(274-276)GAA>AAA	p.E92K	ABLIM3_uc003lpz.1_Missense_Mutation_p.E92K|ABLIM3_uc003lqa.1_Silent_p.A73A|ABLIM3_uc003lqb.2_Missense_Mutation_p.E92K|ABLIM3_uc003lqc.1_Missense_Mutation_p.E92K|ABLIM3_uc003lqd.1_Missense_Mutation_p.E92K|ABLIM3_uc003lqf.2_Missense_Mutation_p.E92K|ABLIM3_uc003lqe.1_Missense_Mutation_p.E92K	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	92	LIM zinc-binding 2.				axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCACAGGCGAAGTCATCTC	0.597												
PDE6A	5145	broad.mit.edu	37	5	149263008	149263008	+	Missense_Mutation	SNP	G	G	A	rs142092713		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:149263008G>A	uc003lrg.3	-	17	2239	c.2119C>T	c.(2119-2121)CGG>TGG	p.R707W		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	707					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ATTTCCTTCCGTGTCTGCTCC	0.473												
FAT2	2196	broad.mit.edu	37	5	150948236	150948236	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:150948236T>G	uc003lue.3	-	1	270	c.257A>C	c.(256-258)GAG>GCG	p.E86A	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.E86A	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	86	Extracellular (Potential).|Cadherin 1.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CACCACATACTCCTCAGTTTT	0.507												
ADRA1B	147	broad.mit.edu	37	5	159399008	159399008	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:159399008G>A	uc003lxt.1	+	2	1245	c.1072G>A	c.(1072-1074)GCT>ACT	p.A358T		NM_000679	NP_000670	P35368	ADA1B_HUMAN	alpha-1B-adrenergic receptor	358	Cytoplasmic (By similarity).				cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			lung(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	GTTCAAGCGCGCTTTCGTGCG	0.502												
DOCK2	1794	broad.mit.edu	37	5	169129410	169129410	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:169129410G>A	uc003maf.2	+	14	1442	c.1362G>A	c.(1360-1362)GCG>GCA	p.A454A	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_5'Flank|DOCK2_uc010jjl.1_Silent_p.A5A	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	454	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTGTGTGCGCGGAGGATGGCA	0.512											OREG0017017	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
GABRP	2568	broad.mit.edu	37	5	170236617	170236617	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:170236617G>A	uc003mau.2	+	9	1076	c.878G>A	c.(877-879)CGC>CAC	p.R293H	GABRP_uc011dev.1_Intron	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	293						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATCGGGTCCCGCACTTCTCTT	0.502											OREG0017032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
STK10	6793	broad.mit.edu	37	5	171614943	171614943	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:171614943A>G	uc003mbo.1	-	1	404	c.104T>C	c.(103-105)GTG>GCG	p.V35A		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	35							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GATCTCCCACACCTCGTTGGG	0.652												
C5orf41	153222	broad.mit.edu	37	5	172513563	172513563	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:172513563G>A	uc003mch.2	+	3	373	c.69G>A	c.(67-69)TCG>TCA	p.S23S	C5orf41_uc003mcg.2_Silent_p.S23S|C5orf41_uc003mcf.2_Silent_p.S23S|C5orf41_uc011dfd.1_Silent_p.S23S	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	23							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ACACCTTTTCGGAACAAACTC	0.413												
HMP19	51617	broad.mit.edu	37	5	173491266	173491266	+	Missense_Mutation	SNP	C	C	T	rs142224266		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:173491266C>T	uc003mcx.2	+	3	306	c.161C>T	c.(160-162)CCG>CTG	p.P54L		NM_015980	NP_057064	Q9Y328	NSG2_HUMAN	HMP19 protein	54	Cytoplasmic (Potential).				dopamine receptor signaling pathway	cytoplasmic vesicle membrane|Golgi cisterna membrane|integral to membrane|multivesicular body membrane	dopamine receptor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00925)|all_lung(126;0.0148)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GAATATCAGCCGGAACAGAAG	0.423												
HK3	3101	broad.mit.edu	37	5	176310832	176310832	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:176310832C>T	uc003mfa.2	-	15	2084	c.1992G>A	c.(1990-1992)ACG>ACA	p.T664T	HK3_uc003mez.2_Silent_p.T220T	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	664	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGTCCCCACCGTGTCATTGA	0.582												
RUFY1	80230	broad.mit.edu	37	5	179021923	179021923	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:179021923A>T	uc003mka.1	+	12	1470	c.1470A>T	c.(1468-1470)AAA>AAT	p.K490N	RUFY1_uc003mkb.1_Missense_Mutation_p.K382N|RUFY1_uc003mkc.1_Missense_Mutation_p.K382N|RUFY1_uc003mkd.1_Missense_Mutation_p.K92N	NM_025158	NP_079434	Q96T51	RUFY1_HUMAN	RUN and FYVE domain-containing 1 isoform a	490	Potential.				endocytosis|protein transport	early endosome membrane	lipid binding|zinc ion binding			ovary(4)|breast(1)	5	all_cancers(89;0.00018)|all_epithelial(37;8.37e-05)|Renal(175;0.000159)|Lung NSC(126;0.00108)|all_lung(126;0.00195)	all_cancers(40;0.0322)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGAAGGAAAAACCAACCAAG	0.473										HNSCC(44;0.11)		
DUSP22	56940	broad.mit.edu	37	6	348155	348155	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:348155G>A	uc003msx.2	+	6	755	c.316G>A	c.(316-318)GTC>ATC	p.V106I	DUSP22_uc011dhn.1_Missense_Mutation_p.V106I|DUSP22_uc003msy.1_Missense_Mutation_p.V63I	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	106	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.V106I(1)		ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CATCATGACCGTCACTGACTT	0.602												
EXOC2	55770	broad.mit.edu	37	6	637806	637806	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:637806G>A	uc003mtd.2	-	2	147	c.13C>T	c.(13-15)CGA>TGA	p.R5*	EXOC2_uc003mte.2_Nonsense_Mutation_p.R5*|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	5					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		GGGGGTTGTCGTGATCGAGAC	0.478												
BPHL	670	broad.mit.edu	37	6	3127615	3127615	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:3127615T>C	uc003mva.2	+	3	400	c.351T>C	c.(349-351)GAT>GAC	p.D117D	BPHL_uc003muz.2_RNA|BPHL_uc011dht.1_RNA|BPHL_uc003muy.2_Silent_p.D100D	NM_004332	NP_004323	Q86WA6	BPHL_HUMAN	biphenyl hydrolase-like precursor	117					cellular amino acid metabolic process|response to toxin	mitochondrion	hydrolase activity				0	Ovarian(93;0.0386)	all_hematologic(90;0.108)				TTGAAAGGGATGCAAAAGATG	0.493												
TUBB2A	7280	broad.mit.edu	37	6	3154798	3154798	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:3154798G>A	uc003mvc.2	-	4	723	c.637C>T	c.(637-639)CGC>TGC	p.R213C	TUBB2A_uc003mvb.2_Missense_Mutation_p.R206C|TUBB2A_uc003mvd.2_Missense_Mutation_p.R176C	NM_001069	NP_001060	Q13885	TBB2A_HUMAN	tubulin, beta 2	213					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			skin(1)	1	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TTCAGGGTGCGGAAGCAGATG	0.612												
BMP6	654	broad.mit.edu	37	6	7862635	7862635	+	Missense_Mutation	SNP	G	G	A	rs144134653		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:7862635G>A	uc003mxu.3	+	4	1286	c.1108G>A	c.(1108-1110)GTG>ATG	p.V370M		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	370					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					TGAGGTGCACGTGCGCACCAC	0.642												
ALDH5A1	7915	broad.mit.edu	37	6	24503644	24503644	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:24503644G>T	uc003neg.2	+	3	620	c.592G>T	c.(592-594)GCT>TCT	p.A198S	ALDH5A1_uc003nef.2_Missense_Mutation_p.A198S	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	198					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	CATAGGCGTGGCTGCAGTCAT	0.567												
SLC17A3	10786	broad.mit.edu	37	6	25862609	25862609	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:25862609G>A	uc003nfi.3	-	3	265	c.155C>T	c.(154-156)ACG>ATG	p.T52M	SLC17A3_uc003nfk.3_Missense_Mutation_p.T52M|SLC17A3_uc011djz.1_Missense_Mutation_p.T52M|SLC17A3_uc011dka.1_Missense_Mutation_p.T52M	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	52					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						TTGTGCTATCGTTGTGAAATT	0.408												
ABT1	29777	broad.mit.edu	37	6	26598515	26598515	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:26598515C>T	uc003nii.2	+	3	492	c.461C>T	c.(460-462)TCC>TTC	p.S154F		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	154					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						TTCACCTGGTCCCACCTCAGC	0.542												
ZNF184	7738	broad.mit.edu	37	6	27419587	27419587	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:27419587C>T	uc003njj.2	-	5	2562	c.1751G>A	c.(1750-1752)CGA>CAA	p.R584Q	ZNF184_uc010jqv.2_Missense_Mutation_p.R584Q|ZNF184_uc003nji.2_Missense_Mutation_p.R584Q	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CTTGTAAGGTCGTTCTCCAGT	0.423												
HIST1H3I	8354	broad.mit.edu	37	6	27839989	27839989	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:27839989G>A	uc003njy.2	-	1	111	c.105C>T	c.(103-105)GGC>GGT	p.G35G		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	35					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCTTCTTGACGCCACCGGTGG	0.667												
PGBD1	84547	broad.mit.edu	37	6	28251732	28251732	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:28251732C>T	uc003nky.2	+	2	512	c.142C>T	c.(142-144)CGG>TGG	p.R48W	PGBD1_uc003nkz.2_Missense_Mutation_p.R48W	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	48	SCAN box.				viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						CCTGCGCTTTCGGCACTTCTG	0.582												
TRIM26	7726	broad.mit.edu	37	6	30154048	30154048	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:30154048C>T	uc003npr.2	-	9	1434	c.1225G>A	c.(1225-1227)GAC>AAC	p.D409N	TRIM26_uc003nps.2_Missense_Mutation_p.D409N|TRIM26_uc010jry.2_Missense_Mutation_p.D139N|TRIM26_uc003npt.2_Missense_Mutation_p.D409N	NM_003449	NP_003440	Q12899	TRI26_HUMAN	tripartite motif-containing 26	409	B30.2/SPRY.						DNA binding|zinc ion binding			ovary(2)|lung(1)	3						GTTTCCCAGTCGTCATATCCA	0.313												
ABCF1	23	broad.mit.edu	37	6	30554313	30554313	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:30554313A>G	uc003nql.2	+	19	2043	c.1948A>G	c.(1948-1950)ATG>GTG	p.M650V	ABCF1_uc003nqm.2_Missense_Mutation_p.M612V|ABCF1_uc010jsb.2_Intron	NM_001025091	NP_001020262	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F, member 1	650	ABC transporter 2.				inflammatory response|translational initiation	nuclear envelope|nuclear envelope|nucleoplasm|nucleoplasm|polysomal ribosome	ATP binding|ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			ovary(2)	2						TGGCATCGACATGGATTCAAG	0.483												
BAT2	7916	broad.mit.edu	37	6	31590652	31590652	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:31590652A>C	uc003nvb.3	+	2	335	c.86A>C	c.(85-87)AAG>ACG	p.K29T	BAT2_uc011dnv.1_RNA|BAT2_uc003nvc.3_Missense_Mutation_p.K29T|SNORA38_uc003nvd.2_5'Flank|BAT2_uc003nve.2_5'Flank	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	29						cytoplasm|nucleus	protein binding				0						TATAAGGGCAAGTCCTTAGAG	0.502												
BAT2	7916	broad.mit.edu	37	6	31597497	31597497	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:31597497G>A	uc003nvb.3	+	14	2378	c.2129G>A	c.(2128-2130)CGG>CAG	p.R710Q	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.R710Q	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	710	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						GCTCTGGGCCGGCCCCCACCC	0.662												
C6orf26	401251	broad.mit.edu	37	6	31731318	31731318	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:31731318G>A	uc003nxa.3	+	2	300	c.241G>A	c.(241-243)GGG>AGG	p.G81R	MSH5_uc003nwz.3_RNA	NM_001039651	NP_001034740	Q5SSQ6	G7D_HUMAN	hypothetical protein LOC401251	81											0						GCTGCATCTAGGGGCCCTTGG	0.607												
SLC44A4	80736	broad.mit.edu	37	6	31833884	31833884	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:31833884G>A	uc010jti.2	-	14	1319	c.1253C>T	c.(1252-1254)TCG>TTG	p.S418L		NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	418	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	CCCTGGGCACGAGGAGTTCAC	0.582												
EGFL8	80864	broad.mit.edu	37	6	32135153	32135153	+	Missense_Mutation	SNP	G	G	A	rs149576421		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:32135153G>A	uc003oab.1	+	7	686	c.628G>A	c.(628-630)GCT>ACT	p.A210T	PPT2_uc003nzy.1_RNA|EGFL8_uc003oac.1_Missense_Mutation_p.A210T	NM_030652	NP_085155	Q99944	EGFL8_HUMAN	NG3 protein precursor	210	Potential.					extracellular region|integral to membrane	calcium ion binding				0						AGATGAGCGCGCTCTGAAGCA	0.652												
HLA-DRA	3122	broad.mit.edu	37	6	32411064	32411064	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:32411064T>C	uc003obh.2	+	3	512	c.431T>C	c.(430-432)GTC>GCC	p.V144A	HLA-DRA_uc003obi.2_Missense_Mutation_p.V119A	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	144	Ig-like C1-type.|Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						GTGGTCAATGTCACGTGGCTT	0.527									T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Kaposi_Sarcoma_Familial_Clustering_of			
TAP2	6891	broad.mit.edu	37	6	32782287	32782287	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:32782287C>T	uc011dqf.1	-	14	2396	c.2274G>A	c.(2272-2274)GGG>GGA	p.G758G	HLA-DOB_uc003oca.2_Silent_p.G151G|HLA-DOB_uc011dqg.1_Silent_p.G151G	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	Error:Variant_position_missing_in_Q03519_after_alignment					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						TCTTGATATCCCCTGGATAGA	0.547												
COL11A2	1302	broad.mit.edu	37	6	33144778	33144778	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:33144778G>A	uc003ocx.1	-	25	2289	c.2061C>T	c.(2059-2061)GAC>GAT	p.D687D	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Silent_p.D601D|COL11A2_uc003ocz.1_Silent_p.D580D	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	687	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CCGGGGGTCCGTCTGAGCCAG	0.607												
B3GALT4	8705	broad.mit.edu	37	6	33245751	33245751	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:33245751G>A	uc003odr.2	+	1	835	c.555G>A	c.(553-555)CTG>CTA	p.L185L		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	185	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						TCCCTGAACTGGTATCAGAGC	0.582												
UHRF1BP1	54887	broad.mit.edu	37	6	34825149	34825149	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:34825149T>C	uc003oju.3	+	12	1709	c.1475T>C	c.(1474-1476)CTT>CCT	p.L492P	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_5'Flank	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	492										ovary(3)	3						TCTACACTCCTTTCCTGCAGT	0.443												
MDGA1	266727	broad.mit.edu	37	6	37619917	37619917	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:37619917G>A	uc003onu.1	-	7	2361	c.1182C>T	c.(1180-1182)CCC>CCT	p.P394P	MDGA1_uc003onw.3_RNA	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	394	Ig-like 4.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						TGGTGACTGCGGGCAGCTCAG	0.602												
ZFAND3	60685	broad.mit.edu	37	6	38120107	38120107	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:38120107T>C	uc003onx.2	+	6	1041	c.626T>C	c.(625-627)GTG>GCG	p.V209A		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	209							DNA binding|zinc ion binding			ovary(1)	1						ATGAAAATGGTGAAGCTGGAC	0.597												
DNAH8	1769	broad.mit.edu	37	6	38840746	38840746	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:38840746C>T	uc003ooe.1	+	49	7251	c.6651C>T	c.(6649-6651)TCC>TCT	p.S2217S		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ACTTAAATTCCGTTTTGGATG	0.378												
UBR2	23304	broad.mit.edu	37	6	42633221	42633221	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:42633221A>G	uc011dur.1	+	33	3773	c.3773A>G	c.(3772-3774)CAG>CGG	p.Q1258R	UBR2_uc011dus.1_Missense_Mutation_p.Q903R|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1258					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			AAAGCATTACAGTTTCTTAGG	0.333												
KIAA0240	23506	broad.mit.edu	37	6	42796237	42796237	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:42796237G>A	uc003osn.1	+	6	317	c.166G>A	c.(166-168)GAT>AAT	p.D56N	KIAA0240_uc003osm.1_Missense_Mutation_p.D56N|KIAA0240_uc011duw.1_Missense_Mutation_p.D56N|KIAA0240_uc003oso.1_Missense_Mutation_p.D56N|KIAA0240_uc003osp.1_Missense_Mutation_p.D56N	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	56										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			TTAGAATGCTGATCCTAAGTC	0.343												
CUL9	23113	broad.mit.edu	37	6	43152490	43152490	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:43152490G>A	uc003ouk.2	+	2	517	c.442G>A	c.(442-444)GTG>ATG	p.V148M	CUL9_uc003ouj.1_Missense_Mutation_p.V148M|CUL9_uc003oul.2_Missense_Mutation_p.V148M|CUL9_uc010jyk.2_Translation_Start_Site|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	148					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CACCATCCACGTGCTCAGTGC	0.622												
TDRD6	221400	broad.mit.edu	37	6	46656522	46656522	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:46656522C>T	uc003oyj.2	+	1	657	c.657C>T	c.(655-657)AGC>AGT	p.S219S	TDRD6_uc010jze.2_Silent_p.S213S	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	219					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CCACTGCTAGCGTGGGCTCCG	0.647												
C6orf138	442213	broad.mit.edu	37	6	47846191	47846191	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:47846191G>T	uc011dwm.1	-	3	2423	c.2338C>A	c.(2338-2340)CTG>ATG	p.L780M	C6orf138_uc011dwn.1_Missense_Mutation_p.L544M	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	797	Helical; (Potential).					integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						AAACAGTGCAGAAGTGTGCAA	0.448												
KIAA1586	57691	broad.mit.edu	37	6	56919147	56919147	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:56919147G>A	uc003pdj.2	+	4	2020	c.1850G>A	c.(1849-1851)CGC>CAC	p.R617H	KIAA1586_uc011dxm.1_Missense_Mutation_p.R590H	NM_020931	NP_065982	Q9HCI6	K1586_HUMAN	hypothetical protein LOC57691	617							nucleic acid binding				0	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATGAACCTACGCCTTTTATCT	0.308												
EYS	346007	broad.mit.edu	37	6	66045023	66045023	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:66045023C>A	uc011dxu.1	-	11	2154	c.1616G>T	c.(1615-1617)TGC>TTC	p.C539F	EYS_uc003peq.2_Missense_Mutation_p.C539F|EYS_uc003per.1_Missense_Mutation_p.C539F	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	539					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CAAACAACTGCATCCATTTGC	0.308												
COL9A1	1297	broad.mit.edu	37	6	71011710	71011710	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:71011710G>A	uc003pfg.3	-	2	241	c.82C>T	c.(82-84)CGC>TGC	p.R28C		NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	28	Nonhelical region (NC4).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						TTACTGGGGCGACGCTTGACA	0.463												
RIMS1	22999	broad.mit.edu	37	6	72678706	72678706	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:72678706C>T	uc003pga.2	+	2	262	c.185C>T	c.(184-186)GCG>GTG	p.A62V		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	62	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AGGGACATGGCGAAGCCTGCT	0.453												
KCNQ5	56479	broad.mit.edu	37	6	73902416	73902416	+	Splice_Site	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:73902416T>C	uc003pgk.2	+	13	2183	c.1836_splice	c.e13+2	p.Q612_splice	KCNQ5_uc011dyh.1_Splice_Site_p.Q631_splice|KCNQ5_uc011dyi.1_Splice_Site_p.Q622_splice|KCNQ5_uc010kat.2_Splice_Site_p.Q603_splice|KCNQ5_uc011dyj.1_Splice_Site_p.Q502_splice|KCNQ5_uc011dyk.1_Splice_Site_p.Q362_splice	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like						protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GAAAAACAGGTACAACTCAAC	0.353												
COL12A1	1303	broad.mit.edu	37	6	75797321	75797321	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:75797321G>T	uc003phs.2	-	65	9319	c.9153C>A	c.(9151-9153)AGC>AGA	p.S3051R	COL12A1_uc003pht.2_Missense_Mutation_p.S1887R	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	3051	Nonhelical region (NC1).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TGTATGGGATGCTGGCACACT	0.537												
COL12A1	1303	broad.mit.edu	37	6	75814988	75814988	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:75814988A>G	uc003phs.2	-	54	8365	c.8199T>C	c.(8197-8199)CCT>CCC	p.P2733P	COL12A1_uc003pht.2_Silent_p.P1569P	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2733	Nonhelical region (NC3).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						TTGGAAAAGCAGGGCATTTTC	0.428												
SNX14	57231	broad.mit.edu	37	6	86223561	86223561	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:86223561T>C	uc003pkr.2	-	26	2803	c.2610A>G	c.(2608-2610)AAA>AAG	p.K870K	SNX14_uc003pkp.2_Silent_p.K733K|SNX14_uc003pkq.2_Silent_p.K476K|SNX14_uc011dzg.1_Silent_p.K818K|SNX14_uc003pks.2_Silent_p.K817K|SNX14_uc003pkt.2_Silent_p.K861K	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	870					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		GTTTTGCTCCTTTTTGCTTAT	0.308												
ANKRD6	22881	broad.mit.edu	37	6	90340559	90340559	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:90340559G>A	uc003pni.3	+	16	2361	c.2020G>A	c.(2020-2022)GCT>ACT	p.A674T	ANKRD6_uc003pne.3_Missense_Mutation_p.A669T|ANKRD6_uc003pnf.3_Missense_Mutation_p.A639T|ANKRD6_uc011dzy.1_Missense_Mutation_p.A674T|ANKRD6_uc010kcd.2_Missense_Mutation_p.A610T|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_Missense_Mutation_p.A270T|LYRM2_uc010kcf.1_Intron|ANKRD6_uc003pnj.3_Missense_Mutation_p.A270T	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	674							protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		TTTTTTTGAGGCTGTTTCTAC	0.522												
MDN1	23195	broad.mit.edu	37	6	90402442	90402442	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:90402442G>A	uc003pnn.1	-	63	10423	c.10307C>T	c.(10306-10308)GCC>GTC	p.A3436V		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3436					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CAAGGCTGTGGCCAGGGTCCC	0.567												
BACH2	60468	broad.mit.edu	37	6	90642584	90642584	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:90642584G>A	uc011eab.1	-	9	2878	c.2069C>T	c.(2068-2070)TCA>TTA	p.S690L	BACH2_uc003pnw.2_Missense_Mutation_p.S690L	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	690	Leucine-zipper.					nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		ATTCCTCTCTGACAACAGTTT	0.493												
EPHA7	2045	broad.mit.edu	37	6	93967182	93967182	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:93967182T>C	uc003poe.2	-	12	2411	c.2170A>G	c.(2170-2172)AGG>GGG	p.R724G	EPHA7_uc003pof.2_Missense_Mutation_p.R719G|EPHA7_uc011eac.1_Missense_Mutation_p.R720G	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	724	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GTACTTACCCTGAGAAATGCA	0.328												
KLHL32	114792	broad.mit.edu	37	6	97587132	97587132	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:97587132C>T	uc010kcm.1	+	11	2309	c.1837C>T	c.(1837-1839)CCT>TCT	p.P613S	KLHL32_uc011ead.1_Missense_Mutation_p.P577S|KLHL32_uc003poz.2_Missense_Mutation_p.P169S|KLHL32_uc011eae.1_Missense_Mutation_p.P544S|KLHL32_uc003ppa.2_RNA	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	613										ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TCTTCAAGTGCCTCATCACAG	0.458												
C6orf167	253714	broad.mit.edu	37	6	97711260	97711260	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:97711260A>G	uc003ppb.2	-	9	1159	c.893T>C	c.(892-894)GTT>GCT	p.V298A	C6orf167_uc011eaf.1_Missense_Mutation_p.V298A|C6orf167_uc010kcn.1_Missense_Mutation_p.V72A|C6orf167_uc010kco.1_Intron|C6orf167_uc003ppc.2_Missense_Mutation_p.V298A	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	298					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		AATAAGTAGAACCCATAATTC	0.313												
C6orf186	728464	broad.mit.edu	37	6	110620298	110620298	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:110620298C>A	uc010kdu.1	-	4	613	c.613G>T	c.(613-615)GTG>TTG	p.V205L	C6orf186_uc003pub.2_Missense_Mutation_p.V8L	NM_001123364	NP_001116836	Q5JXM2	CF186_HUMAN	chromosome 6 open reading frame 186 precursor	205						extracellular region					0						AAACGATGCACTTCACATCCG	0.458												
ROS1	6098	broad.mit.edu	37	6	117674208	117674208	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:117674208C>A	uc003pxp.1	-	26	4465	c.4266G>T	c.(4264-4266)AAG>AAT	p.K1422N	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1422	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TCCTTAGGGCCTTCACCTGGG	0.443			T	GOPC|ROS1	glioblastoma|NSCLC							
GJA1	2697	broad.mit.edu	37	6	121768495	121768495	+	Missense_Mutation	SNP	G	G	A	rs111717577		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:121768495G>A	uc003pyr.2	+	2	752	c.502G>A	c.(502-504)GCC>ACC	p.A168T	GJA1_uc011ebo.1_Missense_Mutation_p.A69T|GJA1_uc011ebp.1_5'UTR	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	168	Helical; (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CTTTGAGGTGGCCTTCTTGCT	0.473												
PTPRK	5796	broad.mit.edu	37	6	128318068	128318068	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:128318068G>T	uc003qbk.2	-	17	3109	c.2742C>A	c.(2740-2742)AAC>AAA	p.N914K	PTPRK_uc003qbj.2_Missense_Mutation_p.N915K|PTPRK_uc010kfc.2_Missense_Mutation_p.N915K|PTPRK_uc011ebu.1_Missense_Mutation_p.N931K	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	914	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TTCCATATCGGTTTTTTGCTC	0.318												
ARHGAP18	93663	broad.mit.edu	37	6	129959703	129959703	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:129959703G>T	uc003qbr.2	-	3	477	c.388C>A	c.(388-390)CCA>ACA	p.P130T	ARHGAP18_uc011ebw.1_Missense_Mutation_p.P130T	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	130					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			ovary(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		CTTTCCTGTGGATCTCCAGCA	0.463												
SHPRH	257218	broad.mit.edu	37	6	146262872	146262872	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:146262872G>A	uc003qlf.2	-	10	2776	c.2377C>T	c.(2377-2379)CGT>TGT	p.R793C	SHPRH_uc003qld.2_Missense_Mutation_p.R793C|SHPRH_uc003qle.2_Missense_Mutation_p.R793C|SHPRH_uc003qlg.1_Missense_Mutation_p.R349C|SHPRH_uc003qlj.1_Missense_Mutation_p.R682C	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	793	Helicase ATP-binding; second part.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CGTAGGCGACGCCCATCCTCA	0.468												
ULBP1	80329	broad.mit.edu	37	6	150290280	150290280	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:150290280G>T	uc003qnp.2	+	3	452	c.409G>T	c.(409-411)GGA>TGA	p.G137*		NM_025218	NP_079494	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1 precursor	137	MHC class I alpha-2 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			pancreas(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		ACACGGCAGAGGATCTTGGCA	0.512												
C6orf211	79624	broad.mit.edu	37	6	151785658	151785658	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:151785658A>T	uc003qok.1	+	4	722	c.463A>T	c.(463-465)ATC>TTC	p.I155F	C6orf211_uc011ees.1_Missense_Mutation_p.I36F	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	155							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		ACAGGAATCCATCATTGCTTT	0.328												
SYNE1	23345	broad.mit.edu	37	6	152469223	152469223	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:152469223C>A	uc010kiw.2	-	137	25535	c.24933G>T	c.(24931-24933)CAG>CAT	p.Q8311H	SYNE1_uc010kiv.2_Missense_Mutation_p.Q2835H|SYNE1_uc003qos.3_Missense_Mutation_p.Q2835H|SYNE1_uc003qot.3_Missense_Mutation_p.Q8240H|SYNE1_uc003qou.3_Missense_Mutation_p.Q8311H|SYNE1_uc003qop.3_Missense_Mutation_p.Q473H|SYNE1_uc011eez.1_Missense_Mutation_p.Q513H|SYNE1_uc003qoq.3_Missense_Mutation_p.Q513H|SYNE1_uc003qor.3_Missense_Mutation_p.Q1211H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8311	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTTGTCATCCTGACCTTCTT	0.512										HNSCC(10;0.0054)		
TIAM2	26230	broad.mit.edu	37	6	155561718	155561718	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:155561718G>A	uc003qqb.2	+	18	4496	c.3223G>A	c.(3223-3225)GGC>AGC	p.G1075S	TIAM2_uc003qqe.2_Missense_Mutation_p.G1075S|TIAM2_uc010kjj.2_Missense_Mutation_p.G608S|TIAM2_uc003qqf.2_Missense_Mutation_p.G451S|TIAM2_uc011efl.1_Missense_Mutation_p.G411S|TIAM2_uc003qqg.2_Missense_Mutation_p.G387S|TIAM2_uc003qqh.2_5'UTR	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1075					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TCAGGCCAACGGCATGGAAGG	0.577												
SYNJ2	8871	broad.mit.edu	37	6	158492720	158492720	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:158492720G>T	uc003qqx.1	+	15	2102	c.2027G>T	c.(2026-2028)AGC>ATC	p.S676I	SYNJ2_uc003qqw.1_Missense_Mutation_p.S676I|SYNJ2_uc003qqy.1_Missense_Mutation_p.S389I|SYNJ2_uc003qqz.1_Missense_Mutation_p.S293I|SYNJ2_uc003qra.1_Missense_Mutation_p.S19I	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	676	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CAGTTCCACAGCACCAGCTTC	0.587												
ACAT2	39	broad.mit.edu	37	6	160199806	160199806	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:160199806C>T	uc010kjy.2	+	9	1270	c.1139C>T	c.(1138-1140)GCA>GTA	p.A380V	ACAT2_uc011efw.1_Missense_Mutation_p.A409V|TCP1_uc003qsr.2_3'UTR|TCP1_uc003qss.2_3'UTR|TCP1_uc010kjz.2_3'UTR|TCP1_uc003qst.2_3'UTR	NM_005891	NP_005882	Q9BWD1	THIC_HUMAN	acetyl-Coenzyme A acetyltransferase 2	380						mitochondrion|nucleolus	acetyl-CoA C-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.51e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CGTGGTGTTGCAGCCCTGTGC	0.468												
LPA	4018	broad.mit.edu	37	6	161027563	161027563	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:161027563C>T	uc003qtl.2	-	18	2851	c.2731G>A	c.(2731-2733)GTC>ATC	p.V911I		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3419	Kringle 30.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGAGGCGCGACGGCAGTCCCT	0.547												
PHF10	55274	broad.mit.edu	37	6	170118937	170118937	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:170118937T>C	uc011egy.1	-	3	351	c.272A>G	c.(271-273)CAA>CGA	p.Q91R	PHF10_uc011egz.1_Missense_Mutation_p.Q91R|PHF10_uc011eha.1_5'Flank	NM_018288	NP_060758	Q8WUB8	PHF10_HUMAN	PHD finger protein 10 isoform a	91	SAY.|Essential to induce neural progenitor proliferation (By similarity).				nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	npBAF complex	zinc ion binding			urinary_tract(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.4e-21)|BRCA - Breast invasive adenocarcinoma(81;1.4e-07)|GBM - Glioblastoma multiforme(31;0.00176)		GACTTGTTCTTGAAGCATATA	0.299												
HEATR2	54919	broad.mit.edu	37	7	769421	769421	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:769421C>T	uc010krz.1	+	2	737	c.717C>T	c.(715-717)AAC>AAT	p.N239N	PRKAR1B_uc003siw.1_5'Flank|HEATR2_uc003siz.2_Silent_p.N107N	NM_017802	NP_060272	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	239	HEAT 2.						protein binding			skin(1)	1		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		ATTTTGGCAACGGGAAGTCCG	0.567												
SUN1	23353	broad.mit.edu	37	7	872217	872217	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:872217C>T	uc011jvp.1	+	2	135	c.56C>T	c.(55-57)ACG>ATG	p.T19M	SUN1_uc010ksa.1_Missense_Mutation_p.T40M|SUN1_uc003sje.1_Missense_Mutation_p.T19M|SUN1_uc003sjf.2_Intron|SUN1_uc011jvq.1_Missense_Mutation_p.T19M	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	19	Nuclear.|LMNA-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						CCGGAGAACACGGGCTACACG	0.567												
EIF3B	8662	broad.mit.edu	37	7	2418871	2418871	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:2418871C>T	uc003slx.2	+	17	2418	c.2335C>T	c.(2335-2337)CGA>TGA	p.R779*	EIF3B_uc003sly.2_Nonsense_Mutation_p.R779*|EIF3B_uc003sma.2_Nonsense_Mutation_p.R507*|EIF3B_uc003smb.2_RNA	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	779					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CCTGGAGTTGCGAGGAGGTAA	0.592												
CYTH3	9265	broad.mit.edu	37	7	6210230	6210230	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:6210230G>A	uc003spt.2	-	9	863	c.759C>T	c.(757-759)GAC>GAT	p.D253D	CYTH3_uc011jws.1_Silent_p.D168D	NM_004227	NP_004218	O43739	CYH3_HUMAN	cytohesin 3	253					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity				0						CGTTCCCGTCGTCCTCCGGGA	0.602												
DNAH11	8701	broad.mit.edu	37	7	21747335	21747335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:21747335C>T	uc003svc.2	+	41	6617	c.6586C>T	c.(6586-6588)CGA>TGA	p.R2196*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2196	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AACACTGAACCGAACATATGT	0.378									Kartagener_syndrome			
IGF2BP3	10643	broad.mit.edu	37	7	23509592	23509592	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:23509592G>A	uc003swg.2	-	1	404	c.138C>T	c.(136-138)GAC>GAT	p.D46D	IGF2BP3_uc003swh.1_RNA	NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	46	RRM 1.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						CCCAGCTCTCGTCCGGGCAGT	0.697												
STK31	56164	broad.mit.edu	37	7	23811811	23811811	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:23811811G>A	uc003sws.3	+	15	1946	c.1879G>A	c.(1879-1881)GAT>AAT	p.D627N	STK31_uc003swt.3_Missense_Mutation_p.D604N|STK31_uc011jze.1_Missense_Mutation_p.D627N|STK31_uc010kuq.2_Missense_Mutation_p.D604N	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	627							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TCCCAGTGTGGATCACTTGCT	0.303												
HOXA3	3200	broad.mit.edu	37	7	27149829	27149829	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:27149829G>T	uc011jzl.1	-	2	631	c.431C>A	c.(430-432)CCC>CAC	p.P144H	HOXA3_uc011jzk.1_5'UTR|HOXA3_uc003syk.2_Missense_Mutation_p.P144H	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	144					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						GTTGAGCAGGGGGCTCTTGGC	0.453												
C7orf41	222166	broad.mit.edu	37	7	30185810	30185810	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:30185810C>T	uc011kab.1	+	2	381	c.180C>T	c.(178-180)AGC>AGT	p.S60S	C7orf41_uc010kvr.1_RNA|C7orf41_uc003tar.1_Silent_p.S60S	NM_152793	NP_690006	Q8N3F0	CG041_HUMAN	hypothetical protein LOC222166	60											0						GGAGTGAGAGCGAGGACTGCC	0.522												
PDE1C	5137	broad.mit.edu	37	7	31890296	31890296	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:31890296G>A	uc003tcm.1	-	8	1279	c.810C>T	c.(808-810)TAC>TAT	p.Y270Y	PDE1C_uc003tcn.1_Silent_p.Y270Y|PDE1C_uc003tco.1_Silent_p.Y330Y|PDE1C_uc003tcr.2_Silent_p.Y270Y|PDE1C_uc003tcs.2_Silent_p.Y270Y	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	270	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			CGGTATGCTCGTAGTCATGGA	0.443												
GLI3	2737	broad.mit.edu	37	7	42005174	42005174	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:42005174C>A	uc011kbh.1	-	15	3588	c.3497G>T	c.(3496-3498)AGC>ATC	p.S1166I	GLI3_uc011kbg.1_Missense_Mutation_p.S1107I	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1166					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GCTTCCGGAGCTGACTTCGTT	0.667									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
GLI3	2737	broad.mit.edu	37	7	42012141	42012141	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:42012141C>A	uc011kbh.1	-	13	1989	c.1898G>T	c.(1897-1899)GGC>GTC	p.G633V	GLI3_uc011kbg.1_Missense_Mutation_p.G574V	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	633					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						AGCCTCTGGGCCATGCACTGT	0.577									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
AEBP1	165	broad.mit.edu	37	7	44151800	44151800	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:44151800T>C	uc003tkb.2	+	17	2402	c.2097T>C	c.(2095-2097)TTT>TTC	p.F699F	AEBP1_uc003tkc.3_Silent_p.F274F|AEBP1_uc003tkd.2_Intron	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	699	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTGACATCTTTGAAGATTTCC	0.587												
ZMIZ2	83637	broad.mit.edu	37	7	44806205	44806205	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:44806205C>T	uc003tlr.2	+	18	2721	c.2598C>T	c.(2596-2598)GGC>GGT	p.G866G	ZMIZ2_uc003tlq.2_Silent_p.G808G|ZMIZ2_uc003tls.2_Silent_p.G840G|ZMIZ2_uc003tlt.2_Silent_p.G489G|ZMIZ2_uc010kyj.2_Silent_p.G388G|ZMIZ2_uc003tlu.2_Silent_p.G147G|ZMIZ2_uc010kyk.1_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	866	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CTGCCACAGGCGTGATGGGGC	0.677												
MYO1G	64005	broad.mit.edu	37	7	45016545	45016545	+	Missense_Mutation	SNP	C	C	T	rs144045009	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:45016545C>T	uc003tmh.2	-	2	365	c.221G>A	c.(220-222)CGG>CAG	p.R74Q	MYO1G_uc003tmg.2_5'Flank|MYO1G_uc010kym.2_Intron|MYO1G_uc003tmi.1_5'UTR|MYO1G_uc003tmj.2_5'UTR	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	74	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						ATGGGGTGGCCGCTCATAGAG	0.627												
ABCA13	154664	broad.mit.edu	37	7	48375117	48375117	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:48375117G>T	uc003toq.2	+	28	10123	c.10098G>T	c.(10096-10098)ATG>ATT	p.M3366I	ABCA13_uc010kys.1_Missense_Mutation_p.M440I|ABCA13_uc003tos.1_Missense_Mutation_p.M192I	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3366					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GTGGCCAGATGTTCAACCAGC	0.483												
ABCA13	154664	broad.mit.edu	37	7	48411974	48411974	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:48411974T>G	uc003toq.2	+	33	11038	c.11013T>G	c.(11011-11013)TTT>TTG	p.F3671L	ABCA13_uc010kys.1_Missense_Mutation_p.F745L|ABCA13_uc003tos.1_Missense_Mutation_p.F497L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3671					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TGAGTGCATTTTTCAGCCAAG	0.428												
COBL	23242	broad.mit.edu	37	7	51097038	51097038	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:51097038C>T	uc003tpr.3	-	10	1940	c.1755G>A	c.(1753-1755)GAG>GAA	p.E585E	COBL_uc003tps.2_Silent_p.E642E|COBL_uc011kcl.1_Silent_p.E585E|COBL_uc003tpp.3_Silent_p.E371E|COBL_uc003tpq.3_Silent_p.E526E|COBL_uc003tpo.3_Silent_p.E127E	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	585										skin(3)|ovary(2)	5	Glioma(55;0.08)					GCTGGCTGTGCTCAGCTTGAA	0.547												
AUTS2	26053	broad.mit.edu	37	7	70255840	70255840	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:70255840C>T	uc003tvw.3	+	19	4381	c.3638C>T	c.(3637-3639)CCG>CTG	p.P1213L	AUTS2_uc003tvx.3_Missense_Mutation_p.P1189L|AUTS2_uc011keg.1_Missense_Mutation_p.P665L	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1213										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		AAGACCCCTCCGACAGCAGCG	0.677												
TBL2	26608	broad.mit.edu	37	7	72985121	72985121	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:72985121T>C	uc003tyh.2	-	7	1194	c.1060A>G	c.(1060-1062)ATT>GTT	p.I354V	TBL2_uc011kex.1_Missense_Mutation_p.I318V|TBL2_uc010lbg.2_Missense_Mutation_p.I259V|TBL2_uc003tyi.2_Missense_Mutation_p.I189V|TBL2_uc011key.1_Missense_Mutation_p.I225V|TBL2_uc010lbh.2_Missense_Mutation_p.I259V	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	354	WD 6.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				TAGAGATGAATACTACTGCCA	0.627												
MLXIPL	51085	broad.mit.edu	37	7	73011554	73011554	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:73011554C>T	uc003tyn.1	-	9	1609	c.1561G>A	c.(1561-1563)GCG>ACG	p.A521T	MLXIPL_uc003tyj.1_5'UTR|MLXIPL_uc003tyk.1_Missense_Mutation_p.A521T|MLXIPL_uc003tyl.1_Missense_Mutation_p.A521T|MLXIPL_uc003tym.1_Missense_Mutation_p.A521T|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.A428T|MLXIPL_uc003tyq.1_Missense_Mutation_p.A263T	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	521					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTGCTCCCCGCAGTGGTGGGG	0.687												
GTF2I	2969	broad.mit.edu	37	7	74159243	74159243	+	Missense_Mutation	SNP	G	G	A	rs139477988		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:74159243G>A	uc003uau.2	+	21	2267	c.1897G>A	c.(1897-1899)GTC>ATC	p.V633I	GTF2I_uc003uav.2_Missense_Mutation_p.V612I|GTF2I_uc003uaw.2_Missense_Mutation_p.V613I|GTF2I_uc003uay.2_Missense_Mutation_p.V611I|GTF2I_uc003uax.2_Missense_Mutation_p.V592I	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	633	GTF2I-like 4.				negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TGAAAGGATCGTCCGCGGGAG	0.418												
POM121C	100101267	broad.mit.edu	37	7	75066870	75066870	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:75066870C>T	uc010lde.1	-	5	1129	c.1129G>A	c.(1129-1131)GCT>ACT	p.A377T	POM121C_uc003udk.3_Missense_Mutation_p.A135T			A8CG34	P121C_HUMAN	Homo sapiens POM121-2 mRNA for nuclear pore membrane protein 121-2, partial cds.	377	Required for targeting to the nucleus and nuclear pore complex.|Pore side (Potential).|Ser-rich.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						CTTGTGTAAGCGCCTGTCAAG	0.507												
SRCRB4D	136853	broad.mit.edu	37	7	76029799	76029799	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:76029799G>A	uc003ufb.2	-	4	627	c.279C>T	c.(277-279)AAC>AAT	p.N93N	ZP3_uc003ufc.3_Intron	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	93	SRCR 1.					extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						GACACACTACGTTGGCGTCCA	0.697												
PCLO	27445	broad.mit.edu	37	7	82390067	82390067	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:82390067G>T	uc003uhx.2	-	24	15465	c.15176C>A	c.(15175-15177)TCT>TAT	p.S5059Y		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4982	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTTTGGGTAGAAATATTCAT	0.299												
KIAA1324L	222223	broad.mit.edu	37	7	86522383	86522383	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:86522383A>G	uc011kha.1	-	20	2904	c.2719T>C	c.(2719-2721)TGC>CGC	p.C907R	KIAA1324L_uc003uif.1_Missense_Mutation_p.C667R|KIAA1324L_uc011kgz.1_Missense_Mutation_p.C793R|KIAA1324L_uc003uie.2_Missense_Mutation_p.C740R	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	907	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					CCTTTAATGCACCATTTAGGT	0.398												
FZD1	8321	broad.mit.edu	37	7	90894471	90894471	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:90894471G>T	uc003ula.2	+	1	689	c.276G>T	c.(274-276)CCG>CCT	p.P92P		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	92	Poly-Pro.|Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CGCCGCCGCCGCCTCAGCAGC	0.517												
MTERF	7978	broad.mit.edu	37	7	91503750	91503750	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:91503750C>T	uc003ulb.1	-	2	402	c.358G>A	c.(358-360)GTG>ATG	p.V120M	MTERF_uc010let.1_Intron|MTERF_uc003ulc.1_Missense_Mutation_p.V120M|MTERF_uc011khm.1_Missense_Mutation_p.V100M|MTERF_uc010leu.1_Missense_Mutation_p.V100M	NM_006980	NP_008911	Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	120					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding				0	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			CTAGCGATCACTTCTTTGCTA	0.438												
COL1A2	1278	broad.mit.edu	37	7	94054966	94054966	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:94054966C>T	uc003ung.1	+	43	3297	c.2826C>T	c.(2824-2826)CCC>CCT	p.P942P	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	942					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	ATGGTCAACCCGGACACAAGG	0.488										HNSCC(75;0.22)		
DLX6	1750	broad.mit.edu	37	7	96639132	96639132	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:96639132C>T	uc003uom.2	+	4	571	c.571C>T	c.(571-573)CGC>TGC	p.R191C	DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	101	Homeobox.				nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					TCAGAACAAACGCTCTAAGTT	0.527												
TRRAP	8295	broad.mit.edu	37	7	98581030	98581030	+	Silent	SNP	C	C	T	rs148646770		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:98581030C>T	uc003upp.2	+	59	9158	c.8949C>T	c.(8947-8949)GAC>GAT	p.D2983D	TRRAP_uc011kis.1_Silent_p.D2965D|TRRAP_uc003upr.2_Silent_p.D2682D	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2983	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCGTGTCTGACGACTTGTCCC	0.408												
ZSCAN21	7589	broad.mit.edu	37	7	99654966	99654966	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:99654966G>A	uc003uso.2	+	2	481	c.337G>A	c.(337-339)GCT>ACT	p.A113T	ZSCAN21_uc011kje.1_Missense_Mutation_p.A112T|ZSCAN21_uc003usn.1_Missense_Mutation_p.A112T	NM_145914	NP_666019	Q9Y5A6	ZSC21_HUMAN	zinc finger protein 38	113	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			CCCGGAGAGCGCTGAAGAGGC	0.592												
C7orf51	222950	broad.mit.edu	37	7	100087129	100087129	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:100087129C>T	uc003uvd.1	+	4	1944	c.1785C>T	c.(1783-1785)ACC>ACT	p.T595T	C7orf51_uc003uve.1_Silent_p.T377T	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	595										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGCAAGGGACCGATGGGGGTG	0.637												
TFR2	7036	broad.mit.edu	37	7	100218519	100218519	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:100218519C>T	uc003uvv.1	-	18	2408	c.2367G>A	c.(2365-2367)GCG>GCA	p.A789A	TFR2_uc010lhc.1_Silent_p.A330A|TFR2_uc003uvu.1_Silent_p.A618A	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	789	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCCGCTAAGCGCATTGGCTG	0.632												
TFR2	7036	broad.mit.edu	37	7	100226903	100226903	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:100226903G>A	uc003uvv.1	-	10	1404	c.1363C>T	c.(1363-1365)CGG>TGG	p.R455W	TFR2_uc010lhc.1_5'UTR|TFR2_uc003uvu.1_Missense_Mutation_p.R284W	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	455	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GAAAAGGTCCGCACCAGCTCC	0.622												
TRIP6	7205	broad.mit.edu	37	7	100468258	100468258	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:100468258C>T	uc003uww.2	+	6	1062	c.892C>T	c.(892-894)CGC>TGC	p.R298C	TRIP6_uc010lhk.1_RNA	NM_003302	NP_003293	Q15654	TRIP6_HUMAN	thyroid receptor-interacting protein 6	298	LIM zinc-binding 1.				focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGCCCTTGATCGCGTCTTTCA	0.597												
PIK3CG	5294	broad.mit.edu	37	7	106508373	106508373	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:106508373C>T	uc003vdv.3	+	2	452	c.367C>T	c.(367-369)CGC>TGC	p.R123C	PIK3CG_uc003vdu.2_Missense_Mutation_p.R123C|PIK3CG_uc003vdw.2_Missense_Mutation_p.R123C	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	123					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GGACTGCCTGCGCTACTGGAA	0.652												
PIK3CG	5294	broad.mit.edu	37	7	106523539	106523539	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:106523539C>A	uc003vdv.3	+	8	2776	c.2691C>A	c.(2689-2691)GGC>GGA	p.G897G	PIK3CG_uc003vdu.2_Silent_p.G897G|PIK3CG_uc003vdw.2_Silent_p.G897G	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	897	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GCACAGTGGGCAACACGGGAG	0.463												
COG5	10466	broad.mit.edu	37	7	107198538	107198538	+	Silent	SNP	G	G	A	rs138518242		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:107198538G>A	uc003ved.2	-	2	735	c.210C>T	c.(208-210)AAC>AAT	p.N70N	COG5_uc003vec.2_Silent_p.N70N|COG5_uc003vee.2_Silent_p.N70N	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	70					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						CAAAGTCTTCGTTTAAAAAGT	0.338												
DOCK4	9732	broad.mit.edu	37	7	111377033	111377033	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:111377033T>C	uc003vfx.2	-	49	5487	c.5218A>G	c.(5218-5220)AAT>GAT	p.N1740D	DOCK4_uc011kml.1_Missense_Mutation_p.N621D|DOCK4_uc011kmm.1_Missense_Mutation_p.N647D|DOCK4_uc003vfw.2_Missense_Mutation_p.N1190D|DOCK4_uc003vfy.2_Missense_Mutation_p.N1785D|DOCK4_uc003vfv.2_Missense_Mutation_p.N53D	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1740	Ser-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				CCAATATGATTAAACAGCATC	0.453												
FOXP2	93986	broad.mit.edu	37	7	114284763	114284763	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:114284763C>T	uc003vhb.2	+	8	1387	c.1013C>T	c.(1012-1014)GCC>GTC	p.A338V	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.A363V|FOXP2_uc003vha.2_Missense_Mutation_p.A246V|FOXP2_uc011kmu.1_Missense_Mutation_p.A355V|FOXP2_uc011kmv.1_Missense_Mutation_p.A337V|FOXP2_uc010ljz.1_Missense_Mutation_p.A246V|FOXP2_uc003vgx.2_Missense_Mutation_p.A338V|FOXP2_uc003vhd.2_Missense_Mutation_p.A338V|FOXP2_uc003vhc.2_Missense_Mutation_p.A363V	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	338					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						GAGACTGGGGCCTCTCACACT	0.438												
ZNF800	168850	broad.mit.edu	37	7	127014061	127014061	+	Silent	SNP	T	T	C	rs17868513		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:127014061T>C	uc003vlx.1	-	5	1592	c.1329A>G	c.(1327-1329)ACA>ACG	p.T443T	ZNF800_uc003vlw.1_Silent_p.T346T|ZNF800_uc003vly.1_Silent_p.T443T|ZNF800_uc010lla.2_Silent_p.T443T	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	443					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTGCTGCCGGTGTGTTCTTTT	0.408												
LRRC4	64101	broad.mit.edu	37	7	127669841	127669841	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:127669841G>T	uc003vmk.2	-	2	990	c.853C>A	c.(853-855)CTC>ATC	p.L285I	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	285	LRR 9.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GGGGTAAAGAGGTCATGGGGC	0.522												
SND1	27044	broad.mit.edu	37	7	127732057	127732057	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:127732057C>T	uc003vmi.2	+	24	2906	c.2680C>T	c.(2680-2682)CGC>TGC	p.R894C	SND1_uc010lle.2_Missense_Mutation_p.R547C	NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	894					gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GAACCTGTGGCGCTATGGAGA	0.572												
FLNC	2318	broad.mit.edu	37	7	128475506	128475506	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:128475506C>T	uc003vnz.3	+	2	688	c.479C>T	c.(478-480)ACG>ATG	p.T160M	FLNC_uc003voa.3_Missense_Mutation_p.T160M	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	160	CH 2.|Actin-binding.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CGCAAACAGACGCCCAAGCAG	0.597												
NRF1	4899	broad.mit.edu	37	7	129394908	129394908	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:129394908G>A	uc003voz.2	+	11	1516	c.1399G>A	c.(1399-1401)GCC>ACC	p.A467T	NRF1_uc003vpa.2_Missense_Mutation_p.A486T|NRF1_uc011kpa.1_Missense_Mutation_p.A306T|NRF1_uc003vpb.2_Missense_Mutation_p.A467T	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	467	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GACCAGCCTCGCCCAGGGCAA	0.612												
CPA5	93979	broad.mit.edu	37	7	129986353	129986353	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:129986353G>A	uc010lmd.1	+	4	647	c.27G>A	c.(25-27)ACG>ACA	p.T9T	CPA5_uc003vps.2_Silent_p.T9T|CPA5_uc003vpt.2_Silent_p.T9T|CPA5_uc010lme.1_Silent_p.T9T|CPA5_uc003vpu.1_Silent_p.T9T	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	9					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					GAGGCGGGACGCGCCCTGGGC	0.627												
PLXNA4	91584	broad.mit.edu	37	7	131864546	131864546	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:131864546A>G	uc003vra.3	-	20	4003	c.3774T>C	c.(3772-3774)ATT>ATC	p.I1258I		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1258	Helical; (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GTTTATAGGCAATGAGCACGG	0.607												
WDR91	29062	broad.mit.edu	37	7	134871064	134871064	+	Missense_Mutation	SNP	C	C	T	rs141164229		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:134871064C>T	uc003vsp.2	-	15	2145	c.2083G>A	c.(2083-2085)GGT>AGT	p.G695S	WDR91_uc010lmq.2_Missense_Mutation_p.G284S|WDR91_uc010lmr.2_RNA	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	695	WD 6.									breast(2)|ovary(1)|skin(1)	4						TCATCGCCACCCAGCTGCAAG	0.587												
NUP205	23165	broad.mit.edu	37	7	135277854	135277854	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:135277854C>T	uc003vsw.2	+	12	1775	c.1744C>T	c.(1744-1746)CGT>TGT	p.R582C		NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	582					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						TGTCCAGTACCGTCACCTTCC	0.483												
DGKI	9162	broad.mit.edu	37	7	137237203	137237203	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:137237203C>A	uc003vtt.2	-	20	2060	c.2059G>T	c.(2059-2061)GCC>TCC	p.A687S	DGKI_uc003vtu.2_Missense_Mutation_p.A387S	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	687					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ATAGCTGGGGCCAACCTACAG	0.517												
KIAA1549	57670	broad.mit.edu	37	7	138554434	138554434	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:138554434C>T	uc011kql.1	-	14	4674	c.4625G>A	c.(4624-4626)CGC>CAC	p.R1542H	KIAA1549_uc011kqi.1_Missense_Mutation_p.R326H|KIAA1549_uc003vuk.3_Missense_Mutation_p.R1492H|KIAA1549_uc011kqj.1_Missense_Mutation_p.R1542H|KIAA1549_uc011kqk.1_Missense_Mutation_p.R326H	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1542						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GTAGTGCCCGCGGCGCTTGGC	0.617			O	BRAF	pilocytic astrocytoma							
KIAA1549	57670	broad.mit.edu	37	7	138602725	138602725	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:138602725C>T	uc011kql.1	-	2	1696	c.1647G>A	c.(1645-1647)ACG>ACA	p.T549T	KIAA1549_uc003vuk.3_Silent_p.T499T|KIAA1549_uc011kqj.1_Silent_p.T549T	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	549	Ser-rich.					integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						CGCTGGATGGCGTCACTTGGG	0.542			O	BRAF	pilocytic astrocytoma							
UBN2	254048	broad.mit.edu	37	7	138968777	138968777	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:138968777T>C	uc011kqr.1	+	15	3126	c.3126T>C	c.(3124-3126)TCT>TCC	p.S1042S		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1042	Ser-rich.									ovary(1)|skin(1)	2						TTGCCGCATCTCCCAAGCCTG	0.527												
MKRN1	23608	broad.mit.edu	37	7	140158906	140158906	+	Silent	SNP	G	G	A	rs1062761		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:140158906G>A	uc003vvt.2	-	4	897	c.672C>T	c.(670-672)TAC>TAT	p.Y224Y	MKRN1_uc003vvs.2_Silent_p.Y160Y|MKRN1_uc011krd.1_Intron|MKRN1_uc003vvv.3_Silent_p.Y224Y|MKRN1_uc003vvu.3_Silent_p.Y160Y	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	224	C3H1-type 3.						ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					AGTTCTCCCCGTATCGGCACT	0.542												
DENND2A	27147	broad.mit.edu	37	7	140273680	140273680	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:140273680G>T	uc010lnj.2	-	4	1519	c.1374C>A	c.(1372-1374)CCC>CCA	p.P458P	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.P458P|DENND2A_uc003vvw.2_Silent_p.P458P|DENND2A_uc003vvx.2_Silent_p.P458P	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	458										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CAGGGCTGCTGGGAGTGGAGG	0.507												
CLCN1	1180	broad.mit.edu	37	7	143039045	143039045	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:143039045G>A	uc003wcr.1	+	15	1693	c.1606G>A	c.(1606-1608)GTT>ATT	p.V536I	CLCN1_uc011ktc.1_Missense_Mutation_p.V148I	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	536					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GACTGGTGCCGTTTCCCACAC	0.517												
CNTNAP2	26047	broad.mit.edu	37	7	147914604	147914604	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:147914604G>A	uc003weu.1	+	19	3751	c.3235G>A	c.(3235-3237)GTC>ATC	p.V1079I		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1079	Laminin G-like 4.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGCAGTCCTCGTCAAACCCAC	0.507										HNSCC(39;0.1)		
ZNF282	8427	broad.mit.edu	37	7	148921287	148921287	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:148921287G>A	uc003wfm.2	+	8	1669	c.1564G>A	c.(1564-1566)GAG>AAG	p.E522K	ZNF282_uc011kun.1_Intron|ZNF282_uc003wfo.2_Silent_p.P198P	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	522	C2H2-type 1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CTCGTGCCCCGAGTGCGGCAA	0.582												
ZNF212	7988	broad.mit.edu	37	7	148947336	148947336	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:148947336C>T	uc003wfp.2	+	2	207	c.111C>T	c.(109-111)ACC>ACT	p.T37T		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			TTCAGACCACCGAGATTTCAC	0.537												
ZNF212	7988	broad.mit.edu	37	7	148951367	148951367	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:148951367C>T	uc003wfp.2	+	5	1445	c.1349C>T	c.(1348-1350)ACG>ATG	p.T450M		NM_012256	NP_036388	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			CGCATCCACACGGGTGAGCGG	0.597												
KRBA1	84626	broad.mit.edu	37	7	149420936	149420936	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:149420936G>A	uc003wfz.2	+	8	1283	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_5'UTR	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	295										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTGGGGAACCGACGGCTACAG	0.622												
SSPO	23145	broad.mit.edu	37	7	149522374	149522374	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:149522374C>T	uc010lpk.2	+	101	14001	c.14001C>T	c.(13999-14001)TGC>TGT	p.C4667C	SSPO_uc010lpm.1_RNA|SSPO_uc003wgg.2_RNA|SSPO_uc003wgh.2_RNA|SSPO_uc003wgi.1_RNA	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4667	TIL 6.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTTAGAGCTGCGAGGCCCAAG	0.627												
CHPF2	54480	broad.mit.edu	37	7	150934480	150934480	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:150934480C>T	uc003wjr.1	+	4	2545	c.1032C>T	c.(1030-1032)ACC>ACT	p.T344T	CHPF2_uc003wjq.1_Silent_p.T336T|MIR671_hsa-mir-671|MI0003760_5'Flank	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	344	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						GGAACCTGACCGTGCTGACCC	0.567												
CRYGN	155051	broad.mit.edu	37	7	151135154	151135154	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:151135154G>A	uc003wke.2	-	2	294	c.198C>T	c.(196-198)CAC>CAT	p.H66H	CRYGN_uc003wkf.2_Silent_p.H66H|CRYGN_uc003wkg.2_RNA|CRYGN_uc010lqd.1_5'Flank	NM_144727	NP_653328	Q8WXF5	CRGN_HUMAN	gammaN-crystallin	66	Beta/gamma crystallin 'Greek key' 2.										0			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGTAGTCGCCGTGCTCCAAGA	0.612												
GALNT11	63917	broad.mit.edu	37	7	151818747	151818747	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:151818747G>A	uc010lqg.1	+	12	2042	c.1812G>A	c.(1810-1812)TGG>TGA	p.W604*	GALNT11_uc011kvm.1_Nonsense_Mutation_p.W523*|GALNT11_uc003wku.2_Nonsense_Mutation_p.W604*	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	604	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		CACAGCAGTGGCATTTGGAAG	0.582												
ZNF596	169270	broad.mit.edu	37	8	192901	192901	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:192901C>T	uc003wot.2	+	3	315	c.27C>T	c.(25-27)TTC>TTT	p.F9F	ZNF596_uc003wou.2_5'UTR|ZNF596_uc003wov.2_Silent_p.F9F|ZNF596_uc003wow.2_Silent_p.F9F	NM_173539	NP_775810	Q8TC21	ZN596_HUMAN	zinc finger protein 596	9	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		CCATGACCTTCGAGGATATCA	0.438												
FBXO25	26260	broad.mit.edu	37	8	400034	400034	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:400034C>T	uc003wox.2	+	6	692	c.426C>T	c.(424-426)GGC>GGT	p.G142G	FBXO25_uc003woy.2_Silent_p.G142G|FBXO25_uc003woz.2_Silent_p.G75G|FBXO25_uc003wpa.2_5'UTR	NM_183421	NP_904357	Q8TCJ0	FBX25_HUMAN	F-box only protein 25 isoform 1	142						nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			lung(1)	1		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		CATTGAGTGGCGTGGCACAGA	0.318												
CSMD1	64478	broad.mit.edu	37	8	2857580	2857580	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:2857580C>T	uc011kwk.1	-	53	8496	c.8106G>A	c.(8104-8106)ACG>ACA	p.T2702T	CSMD1_uc011kwj.1_Silent_p.T2031T|CSMD1_uc010lrg.2_Silent_p.T712T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2702	Extracellular (Potential).|Sushi 18.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGTAAACCACCGTGTCTCTGT	0.493												
SGK223	157285	broad.mit.edu	37	8	8176553	8176553	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:8176553G>A	uc003wsh.3	-	5	3332	c.3332C>T	c.(3331-3333)GCG>GTG	p.A1111V		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1111	Protein kinase.		A -> T.				ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CTCGGGCTCCGCCTGGTGGCT	0.682												
SGK223	157285	broad.mit.edu	37	8	8233918	8233918	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:8233918C>T	uc003wsh.3	-	2	2001	c.2001G>A	c.(1999-2001)ACG>ACA	p.T667T		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	667							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GGTGCCAGGTCGTGGAGTTTG	0.562												
MFHAS1	9258	broad.mit.edu	37	8	8747883	8747883	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:8747883C>T	uc003wsj.1	-	1	3249	c.2686G>A	c.(2686-2688)GCA>ACA	p.A896T		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	896											0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		CTGTAGCGTGCAAACAACCCA	0.458												
XKR6	286046	broad.mit.edu	37	8	11058385	11058385	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:11058385C>T	uc003wtk.1	-	1	491	c.464G>A	c.(463-465)CGC>CAC	p.R155H		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	155						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		GTCCCCCTTGCGGTAGTAGTC	0.652												
MTMR9	66036	broad.mit.edu	37	8	11157593	11157593	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:11157593A>G	uc003wtm.2	+	3	751	c.353A>G	c.(352-354)GAA>GGA	p.E118G	MTMR9_uc010lrx.2_Missense_Mutation_p.E11G|MTMR9_uc011kxa.1_Missense_Mutation_p.E33G	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	118						cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		CCTATGTTTGAAGTGATAGAA	0.403												
MTMR9	66036	broad.mit.edu	37	8	11172485	11172485	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:11172485A>G	uc003wtm.2	+	7	1423	c.1025A>G	c.(1024-1026)CAG>CGG	p.Q342R	MTMR9_uc010lrx.2_Missense_Mutation_p.Q235R|MTMR9_uc011kxa.1_Missense_Mutation_p.Q257R	NM_015458	NP_056273	Q96QG7	MTMR9_HUMAN	myotubularin related protein 9	342	Myotubularin phosphatase.					cytoplasm	phosphatase activity|protein binding				0			STAD - Stomach adenocarcinoma(15;0.215)	COAD - Colon adenocarcinoma(149;0.0678)		TCCACACTCCAGGTGACCTCC	0.478												
FAM167A	83648	broad.mit.edu	37	8	11301555	11301555	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:11301555C>T	uc010lry.1	-	2	986	c.366G>A	c.(364-366)TGG>TGA	p.W122*	FAM167A_uc003wtw.2_Nonsense_Mutation_p.W122*	NM_053279	NP_444509	Q96KS9	F167A_HUMAN	hypothetical protein LOC83648	122	Potential.										0						CCTTCCTGAGCCAGGCTATAG	0.488												
GATA4	2626	broad.mit.edu	37	8	11615981	11615981	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:11615981G>A	uc003wuc.2	+	7	1880	c.1326G>A	c.(1324-1326)GCG>GCA	p.A442A	GATA4_uc003wub.1_Silent_p.A236A|GATA4_uc011kxc.1_Silent_p.A443A|uc003wud.1_5'Flank	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	442					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		TAATCACTGCGTAATCTTCCC	0.602												
HR	55806	broad.mit.edu	37	8	21985180	21985180	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:21985180G>A	uc003xas.2	-	3	1440	c.775C>T	c.(775-777)CGG>TGG	p.R259W	HR_uc003xat.2_Missense_Mutation_p.R259W	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	259							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		TTCTGCTGCCGGCCAGCTCCC	0.627												
NKX3-1	4824	broad.mit.edu	37	8	23538896	23538896	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:23538896T>C	uc011kzx.1	-	2	591	c.543A>G	c.(541-543)CGA>CGG	p.R181R	NKX3-1_uc003xdv.1_Intron	NM_006167	NP_006158	Q99801	NKX31_HUMAN	NK3 homeobox 1	181	Homeobox.				negative regulation of estrogen receptor binding|negative regulation of transcription, DNA-dependent|positive regulation of cell division|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	nucleus	estrogen receptor activity|estrogen receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region sequence-specific DNA binding				0		Prostate(55;0.114)		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)|BRCA - Breast invasive adenocarcinoma(99;0.0708)		AGAGCTGCTTTCGCTTAGTCT	0.582												
ADAMDEC1	27299	broad.mit.edu	37	8	24256965	24256965	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:24256965C>A	uc003xdz.2	+	10	1209	c.989C>A	c.(988-990)CCA>CAA	p.P330Q	ADAMDEC1_uc010lub.2_Missense_Mutation_p.P251Q|ADAMDEC1_uc011lab.1_Missense_Mutation_p.P251Q	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	330	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TTGTGTTCCCCATCTTCGGTT	0.333												
NEFM	4741	broad.mit.edu	37	8	24771893	24771893	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:24771893G>A	uc003xed.3	+	1	620	c.587G>A	c.(586-588)CGC>CAC	p.R196H	NEFM_uc011lac.1_Missense_Mutation_p.R196H|NEFM_uc010lue.2_5'Flank|uc010luc.1_Missense_Mutation_p.R59C	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	196	Rod.|Coil 1B.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GCGCGGTTGCGCGACGACACT	0.632												
DOCK5	80005	broad.mit.edu	37	8	25246735	25246735	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:25246735G>A	uc003xeg.2	+	41	4397	c.4260G>A	c.(4258-4260)TCG>TCA	p.S1420S	PPP2R2A_uc003xek.2_Silent_p.S209S|DOCK5_uc003xei.2_Silent_p.S990S|DOCK5_uc003xej.2_RNA	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1420	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		ACATCAAGTCGTCCCCCAAGC	0.567												
PNMA2	10687	broad.mit.edu	37	8	26365705	26365705	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:26365705C>T	uc003xez.2	-	3	1337	c.567G>A	c.(565-567)ACG>ACA	p.T189T		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	189					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		tgactatctccgtggcctgtt	0												
PTK2B	2185	broad.mit.edu	37	8	27297938	27297938	+	Silent	SNP	C	C	T	rs149334019		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:27297938C>T	uc003xfn.1	+	26	2827	c.2019C>T	c.(2017-2019)ACC>ACT	p.T673T	PTK2B_uc003xfo.1_Silent_p.T673T|PTK2B_uc003xfp.1_Silent_p.T673T|PTK2B_uc003xfq.1_Silent_p.T673T|PTK2B_uc003xfr.1_Silent_p.T419T	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	673	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CCCGCTTCACCGAGCTGGTGT	0.647												
CCDC25	55246	broad.mit.edu	37	8	27606032	27606032	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:27606032C>A	uc003xgc.2	-	6	441	c.328G>T	c.(328-330)GGC>TGC	p.G110C	CCDC25_uc003xgd.2_Missense_Mutation_p.G42C|CCDC25_uc011lan.1_Intron|CCDC25_uc011lao.1_Intron|CCDC25_uc003xge.2_Intron|CCDC25_uc003xgf.1_RNA	NM_018246	NP_060716	Q86WR0	CCD25_HUMAN	coiled-coil domain containing 25	110											0		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0223)|KIRC - Kidney renal clear cell carcinoma(542;0.11)|Kidney(114;0.131)|Colorectal(74;0.154)		CTGTGAAAGCCTATCTGCCCC	0.473												
EXTL3	2137	broad.mit.edu	37	8	28574843	28574843	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:28574843G>A	uc003xgz.1	+	3	1860	c.1267G>A	c.(1267-1269)GAA>AAA	p.E423K		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	423	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		GGACCGCTTGGAATTGCTGAA	0.587												
DUSP4	1846	broad.mit.edu	37	8	29195944	29195944	+	Silent	SNP	G	G	A	rs111661543	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:29195944G>A	uc003xhm.2	-	3	1044	c.654C>T	c.(652-654)GAC>GAT	p.D218D	DUSP4_uc003xhl.2_Silent_p.D127D	NM_001394	NP_001385	Q13115	DUS4_HUMAN	dual specificity phosphatase 4 isoform 1	218	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			lung(1)	1				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		TGCCCAGGGCGTCCAGCATGT	0.562												
WRN	7486	broad.mit.edu	37	8	30999110	30999110	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:30999110G>A	uc003xio.3	+	25	3920	c.3132G>A	c.(3130-3132)ACG>ACA	p.T1044T	WRN_uc010lvk.2_Silent_p.T511T	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1044					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		GCGCCCTTACGAAAAAGGTAA	0.403			Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome			
GPR124	25960	broad.mit.edu	37	8	37689008	37689008	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:37689008C>T	uc003xkj.2	+	8	1363	c.1000C>T	c.(1000-1002)CAA>TAA	p.Q334*	GPR124_uc010lvy.2_Nonsense_Mutation_p.Q334*	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	334	Extracellular (Potential).|Ig-like.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GTCCATGGCCCAAGGCAACGC	0.647												
BRF2	55290	broad.mit.edu	37	8	37702376	37702376	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:37702376C>T	uc003xkk.2	-	4	1002	c.892G>A	c.(892-894)GGT>AGT	p.G298S		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	298					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			AGAAGGTCACCGATGTGCTTC	0.622												
BAG4	9530	broad.mit.edu	37	8	38066655	38066655	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:38066655G>A	uc003xky.1	+	4	1040	c.758G>A	c.(757-759)GGC>GAC	p.G253D	BAG4_uc003xkz.1_Missense_Mutation_p.G217D	NM_004874	NP_004865	O95429	BAG4_HUMAN	BCL2-associated athanogene 4	253					anti-apoptosis|apoptosis|protein folding	cytoplasm|nucleus	receptor signaling protein activity			ovary(1)	1	Colorectal(12;0.000442)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.121)				GGAATGGGTGGCCGTTATCCC	0.532												
HTRA4	203100	broad.mit.edu	37	8	38835575	38835575	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:38835575C>T	uc003xmj.2	+	4	990	c.875C>T	c.(874-876)GCA>GTA	p.A292V		NM_153692	NP_710159	P83105	HTRA4_HUMAN	HtrA serine peptidase 4 precursor	292	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity				0		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			ACAGCTACTGCAGGAATTGTC	0.493												
IKBKB	3551	broad.mit.edu	37	8	42176093	42176093	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:42176093G>A	uc003xow.1	+	13	1441	c.1264G>A	c.(1264-1266)GCC>ACC	p.A422T	IKBKB_uc010lxh.1_Missense_Mutation_p.A317T|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.A199T|IKBKB_uc003xox.1_Missense_Mutation_p.A143T|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.A420T|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.A363T	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	422					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GAGGAATCTCGCCTTCTTCCA	0.522												
HOOK3	84376	broad.mit.edu	37	8	42828458	42828458	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:42828458C>T	uc003xpr.2	+	12	1391	c.1149C>T	c.(1147-1149)TCC>TCT	p.S383S	HOOK3_uc010lxq.1_Silent_p.S383S	NM_032410	NP_115786	Q86VS8	HOOK3_HUMAN	golgi-associated microtubule-binding protein	383	Potential.				cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			ovary(1)|breast(1)	2	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			ACAGATTATCCGAAGAATCAA	0.294			T	RET	papillary thyroid							
MCM4	4173	broad.mit.edu	37	8	48887498	48887498	+	Missense_Mutation	SNP	G	G	A	rs140026188		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:48887498G>A	uc003xqk.1	+	15	2436	c.2341G>A	c.(2341-2343)GTG>ATG	p.V781M	MCM4_uc003xql.1_Missense_Mutation_p.V781M|MCM4_uc011ldi.1_Missense_Mutation_p.V768M	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	781					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				GACTGGCATCGTGGACATATC	0.403												
PXDNL	137902	broad.mit.edu	37	8	52321164	52321164	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:52321164G>A	uc003xqu.3	-	17	3121	c.3020C>T	c.(3019-3021)GCG>GTG	p.A1007V	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1007					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGCAGCTCCGCGCCCACGAT	0.622												
SOX17	64321	broad.mit.edu	37	8	55370898	55370898	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:55370898G>A	uc003xsb.3	+	1	404	c.200G>A	c.(199-201)CGT>CAT	p.R67H		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	67					angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			GGCGAGTCCCGTATCCGGCGG	0.682												
XKR4	114786	broad.mit.edu	37	8	56015724	56015724	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:56015724G>A	uc003xsf.2	+	1	708	c.676G>A	c.(676-678)GCG>ACG	p.A226T		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	226						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			CAACATCGCCGCGGCCAACAG	0.652												
PDE7A	5150	broad.mit.edu	37	8	66639133	66639133	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:66639133G>T	uc003xvq.2	-	9	909	c.897C>A	c.(895-897)TTC>TTA	p.F299L	PDE7A_uc003xvr.2_Missense_Mutation_p.F299L|PDE7A_uc003xvp.2_Missense_Mutation_p.F273L	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	299	Catalytic (By similarity).					cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GCAGATGTGAGAATAAGCCTG	0.348												
ADHFE1	137872	broad.mit.edu	37	8	67361171	67361171	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:67361171C>T	uc003xwb.3	+	8	734	c.700C>T	c.(700-702)CGA>TGA	p.R234*	ADHFE1_uc003xwd.3_RNA|ADHFE1_uc003xwc.3_Nonsense_Mutation_p.R186*|ADHFE1_uc003xwe.3_RNA|ADHFE1_uc003xwf.3_RNA|ADHFE1_uc011les.1_Nonsense_Mutation_p.R164*|ADHFE1_uc011leq.1_RNA|ADHFE1_uc011ler.1_RNA	NM_144650	NP_653251	Q8IWW8	HOT_HUMAN	alcohol dehydrogenase, iron containing, 1	234					2-oxoglutarate metabolic process|molecular hydrogen transport	mitochondrial matrix	hydroxyacid-oxoacid transhydrogenase activity|metal ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4		Lung NSC(129;0.197)	Epithelial(68;0.0321)|all cancers(69;0.0751)|BRCA - Breast invasive adenocarcinoma(89;0.0855)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			CATGCCTGCCCGAGTGGTCGC	0.498												
C8orf46	254778	broad.mit.edu	37	8	67405939	67405939	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:67405939T>C	uc003xwg.2	+	1	449	c.56T>C	c.(55-57)GTG>GCG	p.V19A	C8orf46_uc003xwh.2_RNA|C8orf46_uc011let.1_Missense_Mutation_p.V19A	NM_152765	NP_689978	Q8TAG6	CH046_HUMAN	hypothetical protein LOC254778	19										skin(2)	2			Epithelial(68;0.0224)|BRCA - Breast invasive adenocarcinoma(89;0.0508)|all cancers(69;0.0558)|OV - Ovarian serous cystadenocarcinoma(28;0.226)			TTCACCACCGTGATTCCTTCC	0.507												
C8orf45	157777	broad.mit.edu	37	8	67803139	67803139	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:67803139A>G	uc003xwz.3	+	10	1284	c.1113A>G	c.(1111-1113)ATA>ATG	p.I371M	C8orf45_uc011lev.1_Missense_Mutation_p.I371M|C8orf45_uc011lew.1_Missense_Mutation_p.I302M|C8orf45_uc011lex.1_Missense_Mutation_p.I129M|C8orf45_uc003xwy.3_Missense_Mutation_p.I371M	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	371					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CCCGTGGTATACGTCATCTAG	0.363												
CSPP1	79848	broad.mit.edu	37	8	67998286	67998286	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:67998286C>T	uc003xxi.2	+	4	383	c.352C>T	c.(352-354)CGG>TGG	p.R118W	CSPP1_uc003xxg.1_Missense_Mutation_p.R118W|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.R118W|CSPP1_uc003xxk.2_Translation_Start_Site	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	118	Potential.					centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AGACTATGAACGGAAGAAACA	0.303												
PREX2	80243	broad.mit.edu	37	8	68989660	68989660	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:68989660T>A	uc003xxv.1	+	15	1625	c.1598T>A	c.(1597-1599)ATG>AAG	p.M533K	PREX2_uc003xxu.1_Missense_Mutation_p.M533K|PREX2_uc011lez.1_Missense_Mutation_p.M468K	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	533	DEP 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GAAGAGGCAATGATATTTGGC	0.438												
PREX2	80243	broad.mit.edu	37	8	69046300	69046300	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:69046300A>G	uc003xxv.1	+	32	3800	c.3773A>G	c.(3772-3774)GAG>GGG	p.E1258G		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1258					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ACAGATAGTGAGACACAGCTC	0.458												
PREX2	80243	broad.mit.edu	37	8	69046345	69046345	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:69046345C>T	uc003xxv.1	+	32	3845	c.3818C>T	c.(3817-3819)GCC>GTC	p.A1273V		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1273					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ACTCTTGTGGCCACTGTCTGT	0.483												
C8orf34	116328	broad.mit.edu	37	8	69351816	69351816	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:69351816A>G	uc010lyz.2	+	2	201	c.152A>G	c.(151-153)AAC>AGC	p.N51S	C8orf34_uc010lyx.1_Missense_Mutation_p.N51S|C8orf34_uc010lyy.1_Missense_Mutation_p.N51S|C8orf34_uc003xyb.2_Missense_Mutation_p.N26S	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	51					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			AAACAAGGGAACCGTGGACAA	0.408												
SULF1	23213	broad.mit.edu	37	8	70501233	70501233	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:70501233C>T	uc010lza.1	+	8	1308	c.591C>T	c.(589-591)AAC>AAT	p.N197N	SULF1_uc003xyd.2_Silent_p.N197N|SULF1_uc003xye.2_Silent_p.N197N|SULF1_uc003xyf.2_Silent_p.N197N|SULF1_uc003xyg.2_Silent_p.N197N	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	197					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TAATCACTAACGAGAGCATTA	0.423												
SULF1	23213	broad.mit.edu	37	8	70517125	70517125	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:70517125C>T	uc010lza.1	+	13	2052	c.1335C>T	c.(1333-1335)TGC>TGT	p.C445C	SULF1_uc003xyd.2_Silent_p.C445C|SULF1_uc003xye.2_Silent_p.C445C|SULF1_uc003xyf.2_Silent_p.C445C|SULF1_uc003xyg.2_Silent_p.C445C|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	445					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AAGAACTATGCCAGCAGGCCA	0.458												
SULF1	23213	broad.mit.edu	37	8	70536319	70536319	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:70536319A>G	uc010lza.1	+	15	2454	c.1737A>G	c.(1735-1737)GAA>GAG	p.E579E	SULF1_uc003xyd.2_Silent_p.E579E|SULF1_uc003xye.2_Silent_p.E579E|SULF1_uc003xyf.2_Silent_p.E579E|SULF1_uc003xyg.2_Silent_p.E579E|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	579					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GTCATGATGAAGGCCACAAGG	0.502												
EYA1	2138	broad.mit.edu	37	8	72229848	72229848	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:72229848G>A	uc003xys.3	-	6	782	c.495C>T	c.(493-495)AGC>AGT	p.S165S	EYA1_uc003xyr.3_Silent_p.S160S|EYA1_uc003xyt.3_Silent_p.S132S|EYA1_uc010lzf.2_Silent_p.S92S|EYA1_uc003xyu.2_Silent_p.S165S|EYA1_uc011lfe.1_Silent_p.S159S|EYA1_uc003xyv.2_Silent_p.S43S	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	165					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TTGTGCCATAGCTGAGAAATC	0.463												
STAU2	27067	broad.mit.edu	37	8	74464497	74464497	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:74464497C>T	uc003xzm.2	-	13	1516	c.1280G>A	c.(1279-1281)CGC>CAC	p.R427H	STAU2_uc011lfg.1_Missense_Mutation_p.R255H|STAU2_uc003xzn.2_Missense_Mutation_p.R395H|STAU2_uc011lfh.1_Missense_Mutation_p.R323H|STAU2_uc003xzo.2_Missense_Mutation_p.R427H|STAU2_uc003xzp.2_Missense_Mutation_p.R395H|STAU2_uc011lfi.1_Missense_Mutation_p.R389H|STAU2_uc003xzq.2_Missense_Mutation_p.R207H|STAU2_uc010lzk.2_Missense_Mutation_p.R395H|STAU2_uc010lzl.1_Missense_Mutation_p.R255H	NM_014393	NP_055208	Q9NUL3	STAU2_HUMAN	staufen homolog 2 isoform e	427	Required for dendritic transport (By similarity).				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding				0	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TACTTTGTGGCGGCTGGCTTC	0.373												
ZNF704	619279	broad.mit.edu	37	8	81555314	81555314	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:81555314C>T	uc003yby.1	-	8	1315	c.1083G>A	c.(1081-1083)GCG>GCA	p.A361A		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	361						intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			GGACCGTGTGCGCATGCTGTC	0.522												
ATP6V0D2	245972	broad.mit.edu	37	8	87111213	87111213	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:87111213C>T	uc003ydp.1	+	1	75	c.6C>T	c.(4-6)CTC>CTT	p.L2L		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	2					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						CCCCCATGCTCGAAGGTGCGG	0.552												
RIPK2	8767	broad.mit.edu	37	8	90796355	90796355	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:90796355T>C	uc003yee.2	+	8	1331	c.1017T>C	c.(1015-1017)CAT>CAC	p.H339H	RIPK2_uc003yef.2_Silent_p.H202H	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	339					activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			CTGTAAATCATGGTCCACAAG	0.239												
RUNX1T1	862	broad.mit.edu	37	8	93088227	93088227	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:93088227G>A	uc003yfd.2	-	1	138	c.54C>T	c.(52-54)GAC>GAT	p.D18D	RUNX1T1_uc003yfe.1_Intron|RUNX1T1_uc010mao.2_5'UTR|RUNX1T1_uc011lgi.1_Intron|RUNX1T1_uc003yfh.1_Intron	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	18					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTTTCCGGCAGTCACCTATTA	0.363												
KIAA1429	25962	broad.mit.edu	37	8	95501084	95501084	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:95501084G>T	uc003ygo.1	-	24	5302	c.5289C>A	c.(5287-5289)TAC>TAA	p.Y1763*	KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1763					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GACTTGGGCGGTAACCTGTAA	0.453												
KIAA1429	25962	broad.mit.edu	37	8	95538496	95538496	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:95538496A>T	uc003ygo.1	-	8	1989	c.1976T>A	c.(1975-1977)ATT>AAT	p.I659N	KIAA1429_uc003ygp.2_Missense_Mutation_p.I659N|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	659					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			AGGTCCAGTAATTCGTGCCAT	0.393												
UQCRB	7381	broad.mit.edu	37	8	97243341	97243341	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:97243341G>A	uc003yhq.3	-	4	382	c.278C>T	c.(277-279)CCG>CTG	p.P93L	UQCRB_uc011lgt.1_RNA|UQCRB_uc010mbc.2_RNA	NM_006294	NP_006285	P14927	QCR7_HUMAN	ubiquinol-cytochrome c reductase binding	93					aerobic respiration|mitochondrial electron transport, ubiquinol to cytochrome c	mitochondrial respiratory chain	ubiquinol-cytochrome-c reductase activity			ovary(1)	1	Breast(36;5.16e-05)					TTTCAGATACGGTTCAAGGTA	0.353												
DCAF13	25879	broad.mit.edu	37	8	104427572	104427572	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:104427572T>C	uc003yln.2	+	1	631	c.354T>C	c.(352-354)ACT>ACC	p.T118T	SLC25A32_uc003yll.2_5'Flank|SLC25A32_uc011lhr.1_5'Flank|DCAF13_uc003ylm.1_5'UTR|DCAF13_uc003ylo.2_5'UTR	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	Error:Variant_position_missing_in_Q9NV06_after_alignment					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						GTCACGTGACTGGAAGTAGTC	0.637												
RIMS2	9699	broad.mit.edu	37	8	104897787	104897787	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:104897787C>T	uc003yls.2	+	2	535	c.294C>T	c.(292-294)TAC>TAT	p.Y98Y	RIMS2_uc003ylp.2_Silent_p.Y320Y|RIMS2_uc003ylw.2_Silent_p.Y128Y|RIMS2_uc003ylq.2_Silent_p.Y128Y|RIMS2_uc003ylr.2_Silent_p.Y128Y	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	351					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAGATGAATACGAAAGGCAAA	0.428										HNSCC(12;0.0054)		
RIMS2	9699	broad.mit.edu	37	8	104922390	104922390	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:104922390T>G	uc003yls.2	+	3	1228	c.987T>G	c.(985-987)CAT>CAG	p.H329Q	RIMS2_uc003ylp.2_Missense_Mutation_p.H551Q|RIMS2_uc003ylw.2_Missense_Mutation_p.H359Q|RIMS2_uc003ylq.2_Missense_Mutation_p.H359Q|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_5'Flank	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGTTGGATCATACGTCTTGGC	0.393										HNSCC(12;0.0054)		
OXR1	55074	broad.mit.edu	37	8	107691480	107691480	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:107691480G>A	uc011lht.1	+	3	365	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	OXR1_uc003ymf.2_Missense_Mutation_p.R88Q|OXR1_uc011lhu.1_Missense_Mutation_p.R81Q|OXR1_uc010mcg.2_Intron|OXR1_uc003ymg.1_Missense_Mutation_p.R21Q|OXR1_uc003ymi.1_5'UTR	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	89					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			GATGGAAGACGAATGTCTTTT	0.338												
CSMD3	114788	broad.mit.edu	37	8	113301668	113301668	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:113301668C>T	uc003ynu.2	-	57	9233	c.9074G>A	c.(9073-9075)CGT>CAT	p.R3025H	CSMD3_uc003yns.2_Missense_Mutation_p.R2227H|CSMD3_uc003ynt.2_Missense_Mutation_p.R2985H|CSMD3_uc011lhx.1_Missense_Mutation_p.R2856H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3025	Sushi 21.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAAAAGGGAACGCTTTCCTGT	0.468										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CSMD3	114788	broad.mit.edu	37	8	113308134	113308134	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:113308134G>A	uc003ynu.2	-	54	8701	c.8542C>T	c.(8542-8544)CGA>TGA	p.R2848*	CSMD3_uc003yns.2_Nonsense_Mutation_p.R2050*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.R2808*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.R2679*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2848	Extracellular (Potential).|Sushi 18.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCAATCAATCGAAAACCAGGA	0.403										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CSMD3	114788	broad.mit.edu	37	8	113314034	113314034	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:113314034T>A	uc003ynu.2	-	53	8587	c.8428A>T	c.(8428-8430)ACC>TCC	p.T2810S	CSMD3_uc003yns.2_Missense_Mutation_p.T2012S|CSMD3_uc003ynt.2_Missense_Mutation_p.T2770S|CSMD3_uc011lhx.1_Missense_Mutation_p.T2641S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2810	Extracellular (Potential).|Sushi 17.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGCATCTGGTTTCAGATTCA	0.438										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CSMD3	114788	broad.mit.edu	37	8	113702263	113702263	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:113702263A>C	uc003ynu.2	-	14	2148	c.1989T>G	c.(1987-1989)AGT>AGG	p.S663R	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Missense_Mutation_p.S623R|CSMD3_uc011lhx.1_Missense_Mutation_p.S559R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	663	Extracellular (Potential).|Sushi 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GATCACCACAACTTTCTTTCT	0.363										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
TRPS1	7227	broad.mit.edu	37	8	116617110	116617110	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:116617110T>C	uc003ynz.2	-	3	1506	c.1047A>G	c.(1045-1047)GAA>GAG	p.E349E	TRPS1_uc011lhy.1_Silent_p.E353E|TRPS1_uc003yny.2_Silent_p.E362E|TRPS1_uc010mcy.2_Silent_p.E349E	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	349	C2H2-type 2; atypical.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GTTGTTCTAATTCGGTGGATG	0.413									Langer-Giedion_syndrome			
RAD21	5885	broad.mit.edu	37	8	117866524	117866524	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:117866524G>A	uc003yod.2	-	9	1409	c.1121C>T	c.(1120-1122)TCT>TTT	p.S374F		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	374	Interaction with WAPAL and PDS5B.|Interaction with STAG1.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					AGCAGGTAAAGAAAACAGTTT	0.348												
C8orf85	441376	broad.mit.edu	37	8	117950593	117950593	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:117950593C>T	uc003yof.2	+	1	130	c.111C>T	c.(109-111)TTC>TTT	p.F37F		NM_001025357	NP_001020528	Q4LEZ3	AARD_HUMAN	alanine and arginine-rich domain-containing	37											0						GCGACTTCTTCGGGGACGGCA	0.687												
ENPP2	5168	broad.mit.edu	37	8	120583061	120583061	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:120583061G>A	uc003yot.1	-	20	1887	c.1801C>T	c.(1801-1803)CGA>TGA	p.R601*	ENPP2_uc011lic.1_Nonsense_Mutation_p.R139*|ENPP2_uc003yor.1_Nonsense_Mutation_p.R236*|ENPP2_uc003yos.1_Nonsense_Mutation_p.R653*|ENPP2_uc010mdd.1_Nonsense_Mutation_p.R626*	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	601					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ACTGCAGGTCGCCCATAGAGG	0.338												
TAF2	6873	broad.mit.edu	37	8	120754889	120754889	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:120754889C>T	uc003you.2	-	25	3492	c.3222G>A	c.(3220-3222)TCG>TCA	p.S1074S		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	1074					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GCCGATATTTCGAGAGCCCTA	0.438												
DSCC1	79075	broad.mit.edu	37	8	120865444	120865444	+	Missense_Mutation	SNP	C	C	T	rs143137070		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:120865444C>T	uc003yov.2	-	2	329	c.194G>A	c.(193-195)CGT>CAT	p.R65H		NM_024094	NP_076999	Q9BVC3	DCC1_HUMAN	defective in sister chromatid cohesion 1	65					DNA replication|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|regulation of DNA replication	chromatin|chromosome, centromeric region|nucleoplasm	DNA binding|protein binding			pancreas(1)	1	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTTATCACCACGAATCACAAG	0.393												
ATAD2	29028	broad.mit.edu	37	8	124335285	124335285	+	Nonsense_Mutation	SNP	T	T	A	rs147415119		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:124335285T>A	uc003yqh.3	-	27	4132	c.4024A>T	c.(4024-4026)AAA>TAA	p.K1342*	ATAD2_uc011lii.1_Nonsense_Mutation_p.K1133*|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TGACTTTTTTTAACAACAGTC	0.328												
ANXA13	312	broad.mit.edu	37	8	124707927	124707927	+	Splice_Site	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:124707927C>T	uc003yqu.2	-	5	464	c.391_splice	c.e5+1	p.L131_splice	ANXA13_uc003yqt.2_Splice_Site_p.L172_splice	NM_004306	NP_004297	P27216	ANX13_HUMAN	annexin A13 isoform a						cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			AAGTCACTTACGCCTTTGGTA	0.363												
FER1L6	654463	broad.mit.edu	37	8	125131185	125131185	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:125131185A>T	uc003yqw.2	+	40	5596	c.5390A>T	c.(5389-5391)AAC>ATC	p.N1797I	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1797	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GCCAAGCCCAAGTGAGTGGAG	0.517												
KIAA0196	9897	broad.mit.edu	37	8	126079934	126079934	+	Missense_Mutation	SNP	C	C	T	rs151298198	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:126079934C>T	uc003yrt.2	-	10	1507	c.1178G>A	c.(1177-1179)CGT>CAT	p.R393H	KIAA0196_uc011lir.1_Missense_Mutation_p.R245H|KIAA0196_uc003yru.1_5'UTR	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	393					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CTTGATTTGACGAAGGCGTTT	0.373												
ADCY8	114	broad.mit.edu	37	8	131797706	131797706	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:131797706G>A	uc003ytd.3	-	16	3332	c.3076C>T	c.(3076-3078)CGA>TGA	p.R1026*	ADCY8_uc010mds.2_Nonsense_Mutation_p.R895*	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1026	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TCTTGAAATCGGTCTTCACCA	0.502										HNSCC(32;0.087)		
ADCY8	114	broad.mit.edu	37	8	131848567	131848567	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:131848567G>A	uc003ytd.3	-	12	2887	c.2631C>T	c.(2629-2631)TAC>TAT	p.Y877Y	ADCY8_uc010mds.2_Silent_p.Y746Y	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	877	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGAGGCCTGCGTAGACGGTCT	0.542										HNSCC(32;0.087)		
EFR3A	23167	broad.mit.edu	37	8	133008660	133008660	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:133008660T>G	uc003yte.2	+	19	2274	c.2073T>G	c.(2071-2073)GAT>GAG	p.D691E		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	691						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TAGATGAAGATCGACTTTCTA	0.308												
TG	7038	broad.mit.edu	37	8	133894824	133894824	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:133894824G>A	uc003ytw.2	+	7	897	c.856G>A	c.(856-858)GCA>ACA	p.A286T		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	286	Thyroglobulin type-1 3.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ACGGTTCCTCGCAGTTCAATC	0.473												
WISP1	8840	broad.mit.edu	37	8	134237661	134237661	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:134237661C>T	uc003yub.2	+	4	715	c.639C>T	c.(637-639)CAC>CAT	p.H213H	WISP1_uc003yuc.2_Silent_p.H126H|WISP1_uc010meb.2_Silent_p.H41H|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	213					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			AGGCATGGCACAGGAACTGCA	0.592												
COL22A1	169044	broad.mit.edu	37	8	139820047	139820047	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:139820047C>A	uc003yvd.2	-	10	1905	c.1458G>T	c.(1456-1458)ATG>ATT	p.M486I		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	486	Collagen-like 1.|Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CAGCAACTCCCATTTCACCCT	0.448										HNSCC(7;0.00092)		
COL22A1	169044	broad.mit.edu	37	8	139890011	139890011	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:139890011G>A	uc003yvd.2	-	3	1087	c.640C>T	c.(640-642)CGG>TGG	p.R214W		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	214					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			AGACGGCGCCGCAGCTTGCCC	0.652										HNSCC(7;0.00092)		
PTK2	5747	broad.mit.edu	37	8	141753359	141753359	+	Nonsense_Mutation	SNP	G	G	A	rs139298046		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:141753359G>A	uc003yvu.2	-	20	1935	c.1705C>T	c.(1705-1707)CGA>TGA	p.R569*	PTK2_uc003yvo.2_Nonsense_Mutation_p.R197*|PTK2_uc011ljq.1_Nonsense_Mutation_p.R264*|PTK2_uc003yvp.2_Nonsense_Mutation_p.R237*|PTK2_uc003yvq.2_Nonsense_Mutation_p.R95*|PTK2_uc003yvr.2_Nonsense_Mutation_p.R509*|PTK2_uc003yvs.2_Nonsense_Mutation_p.R569*|PTK2_uc003yvt.2_Nonsense_Mutation_p.R591*|PTK2_uc003yvv.2_Nonsense_Mutation_p.R469*|PTK2_uc011ljr.1_Nonsense_Mutation_p.R569*	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	569	Protein kinase.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TCCATATATCGGGATAATCCA	0.348												
DENND3	22898	broad.mit.edu	37	8	142176464	142176464	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:142176464G>A	uc003yvy.2	+	12	1767	c.1489G>A	c.(1489-1491)GCA>ACA	p.A497T	DENND3_uc010mep.2_Missense_Mutation_p.A458T|DENND3_uc003yvz.1_Missense_Mutation_p.A181T	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	497										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GACGGACACCGCAGGCTGTAG	0.632												
DENND3	22898	broad.mit.edu	37	8	142178455	142178455	+	Silent	SNP	C	C	T	rs147231668		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:142178455C>T	uc003yvy.2	+	13	2144	c.1866C>T	c.(1864-1866)AGC>AGT	p.S622S	DENND3_uc010mep.2_Silent_p.S583S|DENND3_uc003yvz.1_Silent_p.S306S	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	622										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGCTCATCAGCGAGATCCTGG	0.592												
FLJ43860	389690	broad.mit.edu	37	8	142517187	142517187	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:142517187G>A	uc003ywi.2	-	1	144	c.63C>T	c.(61-63)GCC>GCT	p.A21A		NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	21							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TTTGGGACACGGCTGACGACA	0.632												
GPIHBP1	338328	broad.mit.edu	37	8	144295734	144295734	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:144295734C>A	uc003yxu.1	+	2	165	c.90C>A	c.(88-90)GAC>GAA	p.D30E		NM_178172	NP_835466	Q8IV16	HDBP1_HUMAN	glycosylphosphatidylinositol anchored high	30	Poly-Glu.				cholesterol homeostasis|intracellular protein transport|positive regulation of chylomicron remnant clearance|positive regulation of lipoprotein lipase activity|protein import|protein localization at cell surface|protein stabilization|response to heparin|triglyceride homeostasis	anchored to external side of plasma membrane|apical plasma membrane|basolateral plasma membrane|high-density lipoprotein particle|integral to membrane|intracellular	apolipoprotein binding|chylomicron binding|lipase binding|lipid binding|protein transmembrane transporter activity				0	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					aggaagaggacgaggaccacg	0.378												
ZNF696	79943	broad.mit.edu	37	8	144375210	144375210	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:144375210C>T	uc003yxy.3	+	2	448	c.39C>T	c.(37-39)AGC>AGT	p.S13S		NM_030895	NP_112157	Q9H7X3	ZN696_HUMAN	zinc finger protein 696	13					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CTAAAGAGAGCAGTACCCTGA	0.493												
NRBP2	340371	broad.mit.edu	37	8	144919209	144919209	+	Splice_Site	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:144919209A>G	uc011lkt.1	-	14	1403	c.1263_splice	c.e14+1	p.K421_splice	NRBP2_uc003yzv.2_Splice_Site_p.K178_splice|NRBP2_uc003yzz.1_Intron|NRBP2_uc003yzw.2_Splice_Site_p.K213_splice|NRBP2_uc010mfl.2_Splice_Site_p.K213_splice|NRBP2_uc010mfm.2_Splice_Site_p.K178_splice|NRBP2_uc011lks.1_Splice_Site_p.K178_splice|NRBP2_uc003yzy.2_Splice_Site_p.K178_splice	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2						negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GAGGGGACTCACCTTTCTGGT	0.637												
EPPK1	83481	broad.mit.edu	37	8	144941617	144941617	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:144941617G>A	uc003zaa.1	-	1	5818	c.5805C>T	c.(5803-5805)GCC>GCT	p.A1935A		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1935	Plectin 32.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCCGGTGGCGGCCTGCGCCT	0.657												
PLEC	5339	broad.mit.edu	37	8	144998442	144998442	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:144998442C>T	uc003zaf.1	-	31	6236	c.6066G>A	c.(6064-6066)GCG>GCA	p.A2022A	PLEC_uc003zab.1_Silent_p.A1885A|PLEC_uc003zac.1_Silent_p.A1889A|PLEC_uc003zad.2_Silent_p.A1885A|PLEC_uc003zae.1_Silent_p.A1853A|PLEC_uc003zag.1_Silent_p.A1863A|PLEC_uc003zah.2_Silent_p.A1871A|PLEC_uc003zaj.2_Silent_p.A1912A	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2022	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCTTGTGTTGCGCGGCCTGCT	0.706												
GPR172A	79581	broad.mit.edu	37	8	145583577	145583577	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:145583577G>A	uc003zcc.1	+	3	582	c.425G>A	c.(424-426)CGC>CAC	p.R142H	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.R142H|GPR172A_uc003zce.1_Missense_Mutation_p.R142H|GPR172A_uc010mfy.1_Missense_Mutation_p.R142H|GPR172A_uc003zcf.1_Missense_Mutation_p.R142H|GPR172A_uc011llc.1_Missense_Mutation_p.R54H	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	142						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CTGCCACCTCGCTTCTTACGG	0.617												
CPSF1	29894	broad.mit.edu	37	8	145621823	145621823	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:145621823C>A	uc003zcj.2	-	25	2891	c.2816G>T	c.(2815-2817)GGC>GTC	p.G939V		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	939					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCCTGAGTAGCCATAAATATC	0.632												
ZNF34	80778	broad.mit.edu	37	8	145999196	145999196	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:145999196G>A	uc003zdy.3	-	6	1240	c.1138C>T	c.(1138-1140)CGA>TGA	p.R380*	ZNF34_uc010mgb.2_Nonsense_Mutation_p.R277*|ZNF34_uc003zdx.3_Nonsense_Mutation_p.R359*	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	380	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		CGACGATGTCGGATAAGGATT	0.453												
C9orf66	157983	broad.mit.edu	37	9	214857	214857	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:214857C>T	uc003zge.3	-	1	1037	c.540G>A	c.(538-540)GCG>GCA	p.A180A	DOCK8_uc011lls.1_5'Flank|DOCK8_uc003zgf.2_5'Flank	NM_152569	NP_689782	Q5T8R8	CI066_HUMAN	hypothetical protein LOC157983	180										central_nervous_system(1)	1	all_lung(41;0.218)	all_cancers(5;2.09e-12)|all_epithelial(5;6.16e-09)|all_lung(10;1.15e-08)|Lung NSC(10;1.91e-08)|Acute lymphoblastic leukemia(5;0.00457)|all_hematologic(5;0.0332)|Breast(48;0.0646)|Prostate(43;0.137)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		AAGTTTCCAGCGCCGACCGAC	0.701												
SMARCA2	6595	broad.mit.edu	37	9	2054701	2054701	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:2054701G>A	uc003zhc.2	+	6	1250	c.1151G>A	c.(1150-1152)CGG>CAG	p.R384Q	SMARCA2_uc003zhd.2_Missense_Mutation_p.R384Q|SMARCA2_uc010mha.2_Missense_Mutation_p.R375Q	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	384					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AAAGCACTTCGGTTACTCAAT	0.418												
SMARCA2	6595	broad.mit.edu	37	9	2123835	2123835	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:2123835G>T	uc003zhc.2	+	27	3978	c.3879G>T	c.(3877-3879)AGG>AGT	p.R1293S	SMARCA2_uc003zhd.2_Missense_Mutation_p.R1293S|SMARCA2_uc010mha.2_Missense_Mutation_p.R1226S	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1293					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AAGTAGAAAGGCTCACCTGTG	0.572												
KLHL9	55958	broad.mit.edu	37	9	21334793	21334793	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:21334793T>C	uc003zoy.2	-	1	637	c.66A>G	c.(64-66)GGA>GGG	p.G22G	KLHL9_uc003zow.2_Intron|KLHL9_uc003zox.2_RNA	NM_018847	NP_061335	Q9P2J3	KLHL9_HUMAN	kelch-like 9	22					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				ovary(3)|skin(1)	4				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		AGCGTGTGGTTCCTGCCTTAC	0.483												
TEK	7010	broad.mit.edu	37	9	27206739	27206739	+	Missense_Mutation	SNP	C	C	T	rs147231791	by1000genomes	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:27206739C>T	uc003zqi.3	+	15	2966	c.2524C>T	c.(2524-2526)CGC>TGC	p.R842C	TEK_uc011lno.1_Missense_Mutation_p.R799C|TEK_uc011lnp.1_Missense_Mutation_p.R694C|TEK_uc003zqj.1_Missense_Mutation_p.R776C	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	842	Protein kinase.|Cytoplasmic (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TCTTAAGGCGCGCATCAAGAA	0.453												
SPAG8	26206	broad.mit.edu	37	9	35812118	35812118	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:35812118T>C	uc003zye.2	-	1	142	c.27A>G	c.(25-27)GGA>GGG	p.G9G	SPAG8_uc003zyf.2_5'UTR|SPAG8_uc003zyg.2_Silent_p.G9G	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	9						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			GCGACCGCGATCCCTCCGTAG	0.592												
C9orf128	392307	broad.mit.edu	37	9	35825359	35825359	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:35825359G>A	uc010mlc.2	-	3	895	c.610C>T	c.(610-612)CGC>TGC	p.R204C	C9orf128_uc003zyj.2_RNA|C9orf128_uc011lpg.1_Missense_Mutation_p.R204C	NM_001012446	NP_001012448	A6H8Z2	CI128_HUMAN	hypothetical protein LOC392307	204											0	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			AACACTGGGCGGGCTGTGTTA	0.527												
CCIN	881	broad.mit.edu	37	9	36171031	36171031	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:36171031G>A	uc003zzb.3	+	1	1643	c.1532G>A	c.(1531-1533)TGC>TAC	p.C511Y		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	511	Kelch 5.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			CCCAACAGCTGCCCCTTGGAT	0.547												
ZCCHC7	84186	broad.mit.edu	37	9	37126308	37126308	+	Splice_Site	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:37126308G>T	uc003zzq.2	+	2	153	c.-20_splice	c.e2-1		ZCCHC7_uc011lqh.1_Intron|ZCCHC7_uc011lqi.1_Splice_Site|ZCCHC7_uc010mlt.2_Splice_Site|ZCCHC7_uc003zzs.1_Splice_Site	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7								nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)		CTCTTTTGCAGCTTCAAGGTT	0.363												
FRMPD1	22844	broad.mit.edu	37	9	37745690	37745690	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:37745690G>A	uc004aag.1	+	16	3705	c.3661G>A	c.(3661-3663)GTC>ATC	p.V1221I	FRMPD1_uc004aah.1_Missense_Mutation_p.V1221I	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1221						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TTCACCAGCCGTCCCTCCAGA	0.527												
PGM5	5239	broad.mit.edu	37	9	70993121	70993121	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:70993121C>T	uc004agr.2	+	2	497	c.268C>T	c.(268-270)CGA>TGA	p.R90*		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	90					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						TTAGATTGGACGACTGATTAT	0.443												
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:70993145A>G	uc004agr.2	+	2	521	c.292A>G	c.(292-294)ATC>GTC	p.I98V		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						ACAGAATGGCATCTTGTCGAC	0.478												
C9orf41	138199	broad.mit.edu	37	9	77598694	77598694	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:77598694T>C	uc004ajq.2	-	8	1372	c.1219A>G	c.(1219-1221)AAG>GAG	p.K407E	uc004ajp.2_Intron	NM_152420	NP_689633	Q8N4J0	CI041_HUMAN	hypothetical protein LOC138199	407										ovary(1)|skin(1)	2						TATTGTGGCTTACGGACCACA	0.363												
PCSK5	5125	broad.mit.edu	37	9	78710821	78710821	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:78710821G>A	uc004ajz.2	+	8	1448	c.910G>A	c.(910-912)GGC>AGC	p.G304S	PCSK5_uc004ajy.2_Missense_Mutation_p.G304S|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	304	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GAGAGGCCTCGGCTCTGTGTT	0.493												
FLJ46321	389763	broad.mit.edu	37	9	84609582	84609582	+	Silent	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:84609582T>G	uc004amn.2	+	4	4244	c.4197T>G	c.(4195-4197)ACT>ACG	p.T1399T		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1399						integral to membrane					0						TTACTGGGACTACTGAAGCTC	0.453												
AGTPBP1	23287	broad.mit.edu	37	9	88248234	88248234	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:88248234C>T	uc011ltd.1	-	13	1391	c.1358G>A	c.(1357-1359)CGT>CAT	p.R453H	AGTPBP1_uc004aod.3_Missense_Mutation_p.R79H|AGTPBP1_uc011ltc.1_Missense_Mutation_p.R351H|AGTPBP1_uc010mqc.2_Missense_Mutation_p.R413H|AGTPBP1_uc011lte.1_Missense_Mutation_p.R465H	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	453					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						AATAGGACCACGTACTTTTCC	0.333												
SHC3	53358	broad.mit.edu	37	9	91680487	91680487	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:91680487A>G	uc004aqg.2	-	6	1099	c.792T>C	c.(790-792)ACT>ACC	p.T264T		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	264	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						CAACATAGTCAGTTGTGTCCT	0.453												
SYK	6850	broad.mit.edu	37	9	93606314	93606314	+	Missense_Mutation	SNP	G	G	A	rs16906862		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:93606314G>A	uc004aqz.2	+	2	339	c.134G>A	c.(133-135)CGC>CAC	p.R45H	SYK_uc004aqy.2_Missense_Mutation_p.R45H|SYK_uc004ara.2_Missense_Mutation_p.R45H|SYK_uc004arb.2_Missense_Mutation_p.R45H|SYK_uc004arc.2_Missense_Mutation_p.R45H|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	45	SH2 1.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						CGCCAGAGCCGCAACTACCTG	0.617			T	ETV6|ITK	MDS|peripheral T-cell lymphoma							
AUH	549	broad.mit.edu	37	9	93983200	93983200	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:93983200C>T	uc004arf.3	-	7	765	c.730G>A	c.(730-732)GAT>AAT	p.D244N	AUH_uc004arg.3_Missense_Mutation_p.D215N	NM_001698	NP_001689	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-Coenzyme A	244					branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding				0						TCTTTGCCATCGAGGACTCGC	0.577												
ROR2	4920	broad.mit.edu	37	9	94495598	94495598	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:94495598G>A	uc004arj.1	-	6	942	c.743C>T	c.(742-744)CCG>CTG	p.P248L	ROR2_uc004ari.1_Missense_Mutation_p.P108L|ROR2_uc004ark.2_Missense_Mutation_p.P248L	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	248	FZ.|Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						CAGCTCACGCGGCTTGGGTGT	0.647												
PHF2	5253	broad.mit.edu	37	9	96428129	96428129	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:96428129C>T	uc004aub.2	+	15	2246	c.2099C>T	c.(2098-2100)CCG>CTG	p.P700L	PHF2_uc011lug.1_Missense_Mutation_p.P583L|PHF2_uc004auc.2_Missense_Mutation_p.P119L	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	700					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		AAAAACGCCCCGAAAAGGGAC	0.612												
ZNF169	169841	broad.mit.edu	37	9	97062823	97062823	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:97062823G>A	uc004aum.1	+	5	1088	c.983G>A	c.(982-984)CGC>CAC	p.R328H		NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	328	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				CGAGGCTTTCGCCAGAAGATA	0.547												
HIATL1	84641	broad.mit.edu	37	9	97203311	97203311	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:97203311C>T	uc004aur.2	+	5	709	c.440C>T	c.(439-441)ACG>ATG	p.T147M	HIATL1_uc011luh.1_Missense_Mutation_p.T82M	NM_032558	NP_115947	Q5SR56	HIAL1_HUMAN	hippocampus abundant transcript-like 1	147	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	protein binding|transporter activity			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				TTCTCGGTCACGTTTTCTGTT	0.368												
FBP1	2203	broad.mit.edu	37	9	97382707	97382707	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:97382707G>A	uc004auw.3	-	2	568	c.237C>T	c.(235-237)AAC>AAT	p.N79N	FBP1_uc010mrl.2_Silent_p.N79N	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	79					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	TAACCAGGTCGTTGGAGAGGA	0.458												
ZNF510	22869	broad.mit.edu	37	9	99521928	99521928	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:99521928C>T	uc004awn.1	-	6	1373	c.1184G>A	c.(1183-1185)CGA>CAA	p.R395Q	ZNF510_uc004awo.1_Missense_Mutation_p.R395Q	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				GTGACTTCTTCGGCGAACTCT	0.398												
TBC1D2	55357	broad.mit.edu	37	9	100961787	100961787	+	Missense_Mutation	SNP	C	C	T	rs145458773	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:100961787C>T	uc011lvb.1	-	13	2843	c.2663G>A	c.(2662-2664)CGG>CAG	p.R888Q	TBC1D2_uc004ayp.2_Missense_Mutation_p.R428Q|TBC1D2_uc004ayq.2_Missense_Mutation_p.R877Q|TBC1D2_uc004ayr.2_Missense_Mutation_p.R670Q|TBC1D2_uc004ayo.3_3'UTR	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	888	Potential.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		AGCCTCCAGCCGCTCCCGGTG	0.637												
GABBR2	9568	broad.mit.edu	37	9	101304194	101304194	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:101304194G>A	uc004ays.2	-	3	747	c.591C>T	c.(589-591)CGC>CGT	p.R197R		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	197	Extracellular (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GCGTGCCCACGCGCTTCCACT	0.522												
ANKS6	203286	broad.mit.edu	37	9	101536250	101536250	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:101536250G>A	uc004ayu.2	-	9	1751	c.1730C>T	c.(1729-1731)ACG>ATG	p.T577M	ANKS6_uc004ayt.2_Missense_Mutation_p.T276M|ANKS6_uc004ayv.1_Missense_Mutation_p.T39M|ANKS6_uc004ayw.1_Missense_Mutation_p.T159M|ANKS6_uc004ayx.1_RNA|ANKS6_uc004ayy.1_RNA	NM_173551	NP_775822	Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain	577										ovary(2)	2		Acute lymphoblastic leukemia(62;0.0527)				GTTGTGACGCGTCCGGGACCG	0.632												
COL15A1	1306	broad.mit.edu	37	9	101832036	101832036	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:101832036G>A	uc004azb.1	+	42	4241	c.4035G>A	c.(4033-4035)GCG>GCA	p.A1345A		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	1345	Nonhelical region 10 (NC10).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				GGCGAACCGCGGACACAGCGG	0.537												
INVS	27130	broad.mit.edu	37	9	103035177	103035177	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:103035177G>T	uc004bap.1	+	12	1815	c.1603G>T	c.(1603-1605)GAG>TAG	p.E535*	INVS_uc010mta.1_Nonsense_Mutation_p.E439*|INVS_uc011lve.1_Nonsense_Mutation_p.E439*|INVS_uc004bao.1_Nonsense_Mutation_p.E535*|INVS_uc004baq.1_Nonsense_Mutation_p.E439*|INVS_uc004bar.1_Nonsense_Mutation_p.E439*|INVS_uc010mtb.1_Nonsense_Mutation_p.E209*	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	535	ANK 16.				negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				TTTGCTTGGTGAGCGCCATGA	0.428												
SMC2	10592	broad.mit.edu	37	9	106876290	106876290	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:106876290G>A	uc004bbv.2	+	12	1748	c.1460G>A	c.(1459-1461)CGT>CAT	p.R487H	SMC2_uc004bbu.1_Missense_Mutation_p.R487H|SMC2_uc004bbw.2_Missense_Mutation_p.R487H|SMC2_uc011lvl.1_Missense_Mutation_p.R487H|SMC2_uc004bbx.2_Missense_Mutation_p.R487H	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	487	Potential.				cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						CAGCTGTCTCGTGATATTGGT	0.343												
KLF4	9314	broad.mit.edu	37	9	110249320	110249320	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:110249320C>T	uc004bdh.2	-	3	1949	c.1328G>A	c.(1327-1329)CGA>CAA	p.R443Q	KLF4_uc004bdf.1_Missense_Mutation_p.R368Q|KLF4_uc004bdg.2_Missense_Mutation_p.R418Q	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	452	C2H2-type 1.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						TGTGTGGGTTCGCAGGTGTGC	0.587												
EPB41L4B	54566	broad.mit.edu	37	9	112015826	112015826	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:112015826G>A	uc004bdz.1	-	12	1469	c.1174C>T	c.(1174-1176)CGG>TGG	p.R392W	EPB41L4B_uc004bea.2_Missense_Mutation_p.R392W	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	392						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						TATTCTGTCCGCCCACTGGGA	0.423												
PALM2-AKAP2	445815	broad.mit.edu	37	9	112687354	112687354	+	Missense_Mutation	SNP	C	C	T	rs150674445		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:112687354C>T	uc004bei.2	+	5	578	c.386C>T	c.(385-387)ACG>ATG	p.T129M	PALM2_uc004bef.2_Missense_Mutation_p.T131M|PALM2_uc004beg.2_Missense_Mutation_p.T131M|PALM2_uc004beh.3_Missense_Mutation_p.T129M|PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.T129M|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.T129M|PALM2-AKAP2_uc004bel.1_Translation_Start_Site	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:Variant_position_missing_in_Q9Y2D5_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TTCTCCAGTACGGATGGAGGT	0.458												
RGS3	5998	broad.mit.edu	37	9	116359161	116359161	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:116359161G>A	uc004bhq.2	+	26	3734	c.3525G>A	c.(3523-3525)TCG>TCA	p.S1175S	RGS3_uc004bhs.2_Silent_p.S1065S|RGS3_uc004bht.2_Silent_p.S894S|RGS3_uc010muy.2_Silent_p.S568S|RGS3_uc004bhv.2_Silent_p.S496S|RGS3_uc004bhw.2_Silent_p.S145S|RGS3_uc011lxh.1_Silent_p.S485S|RGS3_uc004bhx.2_Silent_p.S496S|RGS3_uc004bhz.2_Silent_p.S517S|RGS3_uc004bia.2_Silent_p.S288S	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	1175	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						AAAAGGACTCGTACCCTCGCT	0.582												
AMBP	259	broad.mit.edu	37	9	116838907	116838907	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:116838907C>T	uc004bie.3	-	2	494	c.231G>A	c.(229-231)GCG>GCA	p.A77A	AMBP_uc011lxk.1_Silent_p.A18A|AMBP_uc010mvc.1_RNA	NM_001633	NP_001624	P02760	AMBP_HUMAN	alpha-1-microglobulin/bikunin preproprotein	77					cell adhesion|female pregnancy|heme catabolic process|interspecies interaction between organisms|negative regulation of immune response|negative regulation of JNK cascade|protein-chromophore linkage	extracellular region|plasma membrane	calcium channel inhibitor activity|calcium oxalate binding|heme binding|IgA binding|protein homodimerization activity|serine-type endopeptidase inhibitor activity|transporter activity			skin(1)	1					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	TGCTGATCTCCGCCTCTGTAG	0.607												
TNFSF8	944	broad.mit.edu	37	9	117692480	117692480	+	Missense_Mutation	SNP	C	C	A	rs139509296		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:117692480C>A	uc004bji.1	-	1	291	c.104G>T	c.(103-105)AGC>ATC	p.S35I		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	35	Cytoplasmic (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						ATAGCTGCGGCTCGTGGTCCC	0.602												
TNC	3371	broad.mit.edu	37	9	117853061	117853061	+	Silent	SNP	C	C	T	rs149512169		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:117853061C>T	uc004bjj.3	-	2	599	c.237G>A	c.(235-237)CCG>CCA	p.P79P	TNC_uc010mvf.2_Silent_p.P79P	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	79					cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GCTCTGAAGGCGGTGCCAGGT	0.562												
ASTN2	23245	broad.mit.edu	37	9	119737508	119737508	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:119737508G>A	uc004bjs.1	-	10	1969	c.1868C>T	c.(1867-1869)ACG>ATG	p.T623M	ASTN2_uc004bjr.1_Missense_Mutation_p.T619M|ASTN2_uc004bjt.1_Missense_Mutation_p.T572M	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	623	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						AGGGTCTTCCGTGACGAGCAC	0.552												
ASTN2	23245	broad.mit.edu	37	9	120053685	120053685	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:120053685C>G	uc004bjs.1	-	2	651	c.550G>C	c.(550-552)GCC>CCC	p.A184P	ASTN2_uc004bjr.1_Missense_Mutation_p.A184P|ASTN2_uc004bjt.1_Missense_Mutation_p.A184P	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	184	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GTGGCTTGGGCCAGCTGCCCG	0.602												
GOLGA1	2800	broad.mit.edu	37	9	127652731	127652731	+	Silent	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:127652731C>A	uc004bpc.2	-	16	1776	c.1434G>T	c.(1432-1434)GTG>GTT	p.V478V	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	478	Potential.|Gln-rich.					Golgi cisterna membrane				ovary(1)	1						TGGCCACGCTCACAATTTCTC	0.532												
SCAI	286205	broad.mit.edu	37	9	127818218	127818218	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:127818218C>A	uc004bpe.2	-	3	248	c.167G>T	c.(166-168)AGG>ATG	p.R56M	SCAI_uc004bpd.2_Missense_Mutation_p.R79M|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	56	Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						AACTGTTTTCCTCTCTCCCTG	0.378												
RABEPK	10244	broad.mit.edu	37	9	127982827	127982827	+	Missense_Mutation	SNP	C	C	T	rs144370574		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:127982827C>T	uc004bpi.2	+	6	547	c.374C>T	c.(373-375)ACG>ATG	p.T125M	RABEPK_uc004bph.1_Missense_Mutation_p.R149C|RABEPK_uc004bpj.2_Missense_Mutation_p.T74M|RABEPK_uc004bpk.2_Missense_Mutation_p.T125M|RABEPK_uc004bpl.1_Missense_Mutation_p.T74M|RABEPK_uc004bpm.2_Missense_Mutation_p.T125M	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	125	Kelch 2.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						GAAACCAGGACGTGGACCACG	0.537												
HSPA5	3309	broad.mit.edu	37	9	127998919	127998919	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:127998919G>A	uc004bpn.2	-	8	2173	c.1917C>T	c.(1915-1917)GGC>GGT	p.G639G		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	639					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	TTGGGGGAGGGCCTGCACTTC	0.413										Prostate(1;0.17)		
ZBTB43	23099	broad.mit.edu	37	9	129595780	129595780	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:129595780A>G	uc004bql.2	+	3	1265	c.992A>G	c.(991-993)GAT>GGT	p.D331G	ZBTB43_uc010mxf.2_Missense_Mutation_p.D331G	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	331					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAGGTCAGATGGGAATCTA	0.458												
ANGPTL2	23452	broad.mit.edu	37	9	129870416	129870416	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:129870416G>A	uc004bqr.1	-	2	1095	c.595C>T	c.(595-597)CAG>TAG	p.Q199*	RALGPS1_uc004bqo.1_Intron|RALGPS1_uc011mab.1_Intron|RALGPS1_uc011mac.1_Intron|RALGPS1_uc004bqq.3_Intron|ANGPTL2_uc010mxg.1_Intron	NM_012098	NP_036230	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2 precursor	199	Potential.				multicellular organismal development|signal transduction	extracellular space	receptor binding				0						TCCTCAAGCTGCGCGATGATC	0.662												
RPL12	6136	broad.mit.edu	37	9	130210644	130210644	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:130210644C>T	uc004bqy.1	-	5	439	c.351G>A	c.(349-351)CGG>CGA	p.R117R	RPL12_uc004bqx.1_RNA|RPL12_uc004bqz.1_Silent_p.R84R	NM_000976	NP_000967	P30050	RL12_HUMAN	ribosomal protein L12	117					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						AGGATCGGTGCCGCATCTGTC	0.418												
SH2D3C	10044	broad.mit.edu	37	9	130507045	130507045	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:130507045G>A	uc004bsc.2	-	7	1740	c.1598C>T	c.(1597-1599)GCC>GTC	p.A533V	SH2D3C_uc010mxo.2_Missense_Mutation_p.A373V|SH2D3C_uc004bry.2_Missense_Mutation_p.A375V|SH2D3C_uc004brz.3_Missense_Mutation_p.A179V|SH2D3C_uc011mak.1_Missense_Mutation_p.A179V|SH2D3C_uc004bsa.2_Missense_Mutation_p.A376V|SH2D3C_uc004bsb.2_Missense_Mutation_p.A465V	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	533					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CCCTTCAGGGGCCCCATTTTC	0.607												
LRRC8A	56262	broad.mit.edu	37	9	131670129	131670129	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:131670129C>T	uc004bwl.3	+	3	940	c.686C>T	c.(685-687)ACG>ATG	p.T229M	LRRC8A_uc010myp.2_Missense_Mutation_p.T229M|LRRC8A_uc010myq.2_Missense_Mutation_p.T229M	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	229					pre-B cell differentiation	integral to membrane					0						CGCTCAGAGACGGGCGTGCTG	0.602												
NUP188	23511	broad.mit.edu	37	9	131755602	131755602	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:131755602A>G	uc004bws.1	+	26	2789	c.2767A>G	c.(2767-2769)ACT>GCT	p.T923A	NUP188_uc004bwu.2_Missense_Mutation_p.T266A	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	923					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						AGAGTTCCTCACTGTTGCAGT	0.502											OREG0019527	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
FAM78A	286336	broad.mit.edu	37	9	134136213	134136213	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:134136213C>T	uc004cak.2	-	2	1188	c.848G>A	c.(847-849)CGG>CAG	p.R283Q	FAM78A_uc004caj.2_Missense_Mutation_p.R280Q	NM_033387	NP_203745	Q5JUQ0	FA78A_HUMAN	hypothetical protein LOC286336	283										ovary(1)	1	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.15e-05)|Epithelial(140;0.000267)		TGGCTGTCACCGGTGCTTGGG	0.567												
NTNG2	84628	broad.mit.edu	37	9	135073517	135073517	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:135073517G>A	uc004cbh.2	+	3	1154	c.378G>A	c.(376-378)TCG>TCA	p.S126S		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	126	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		TCACCCTTTCGTGGAACAAGA	0.632												
SARDH	1757	broad.mit.edu	37	9	136536721	136536721	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:136536721C>T	uc004cep.3	-	18	2396	c.2262G>A	c.(2260-2262)GCG>GCA	p.A754A	SARDH_uc004ceo.2_Silent_p.A754A|SARDH_uc011mdn.1_Silent_p.A754A|SARDH_uc011mdo.1_Silent_p.A586A|SARDH_uc004cen.2_Silent_p.A182A	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	754					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GCTTGGCACCCGCGGCCATCA	0.662												
VAV2	7410	broad.mit.edu	37	9	136660824	136660824	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:136660824C>A	uc004ces.2	-	12	1113	c.1067G>T	c.(1066-1068)AGG>ATG	p.R356M	VAV2_uc004cer.2_Missense_Mutation_p.R351M	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	356	DH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GAGCTGCTGCCTCTCAGGCCG	0.587												
COL5A1	1289	broad.mit.edu	37	9	137674515	137674515	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:137674515T>C	uc004cfe.2	+	29	2815	c.2433T>C	c.(2431-2433)GGT>GGC	p.G811G		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	811	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ATATTCAGGGTGAAGACGGCT	0.577												
FCN1	2219	broad.mit.edu	37	9	137803098	137803098	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:137803098C>T	uc004cfi.2	-	8	706	c.614G>A	c.(613-615)CGT>CAT	p.R205H		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	205	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		CAGGTCTACACGGAGCTCGCT	0.488												
LHX3	8022	broad.mit.edu	37	9	139092502	139092502	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:139092502G>A	uc004cha.2	-	2	274	c.177C>T	c.(175-177)AGC>AGT	p.S59S	LHX3_uc004cgz.2_Silent_p.S64S	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	59	LIM zinc-binding 1.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		TGTGGCAGTCGCTGCACTTGA	0.607												
PMPCA	23203	broad.mit.edu	37	9	139310805	139310805	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:139310805C>T	uc004chl.2	+	6	600	c.595C>T	c.(595-597)CCT>TCT	p.P199S	PMPCA_uc011mdy.1_Missense_Mutation_p.P199S|PMPCA_uc010nbk.2_RNA|PMPCA_uc010nbl.2_Missense_Mutation_p.P99S|PMPCA_uc011mdz.1_Missense_Mutation_p.P68S|PMPCA_uc004chm.1_5'UTR|PMPCA_uc004chn.1_5'Flank	NM_015160	NP_055975	Q10713	MPPA_HUMAN	peptidase (mitochondrial processing) alpha	199					proteolysis	mitochondrial inner membrane|mitochondrial matrix	metalloendopeptidase activity|zinc ion binding				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;9.3e-06)|Epithelial(140;1.15e-05)		GAACCTGCGGCCTGACCCAGA	0.562												
INPP5E	56623	broad.mit.edu	37	9	139328514	139328514	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:139328514C>T	uc004cho.2	-	3	1394	c.1009G>A	c.(1009-1011)GGG>AGG	p.G337R	INPP5E_uc010nbm.2_Missense_Mutation_p.G337R	NM_019892	NP_063945	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase E	337						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			skin(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		TCCTGGACCCCGATGACATAC	0.672												
LCN10	414332	broad.mit.edu	37	9	139635288	139635288	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:139635288G>A	uc010nbq.2	-	3	495	c.436C>T	c.(436-438)CAT>TAT	p.H146Y	LCN10_uc004civ.2_Missense_Mutation_p.H159Y|LCN10_uc011med.1_Intron|LCN10_uc011mee.1_Intron|LCN10_uc011mef.1_Intron|LCN10_uc004ciw.2_RNA			Q6JVE6	LCN10_HUMAN	SubName: Full=LCN10 protein;	146					transport	extracellular region	binding			large_intestine(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.32e-06)|Epithelial(140;7.83e-05)		GCCTGCTCACGGAAGAGCAGC	0.368												
C9orf139	401563	broad.mit.edu	37	9	139927540	139927540	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:139927540C>T	uc004ckp.1	+	2	1539	c.25C>T	c.(25-27)CCC>TCC	p.P9S	FUT7_uc004ckq.2_5'Flank	NM_207511	NP_997394	Q6ZV77	CI139_HUMAN	hypothetical protein LOC401563	9											0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		TCACCCTGAGCCCCAGCCAAC	0.652												
ANAPC2	29882	broad.mit.edu	37	9	140079368	140079368	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:140079368G>A	uc004clr.1	-	4	1118	c.1045C>T	c.(1045-1047)CGA>TGA	p.R349*	ANAPC2_uc004clq.1_Nonsense_Mutation_p.R208*	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	349					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GGACCACCTCGGACGATGCTG	0.672												
ENTPD8	377841	broad.mit.edu	37	9	140331728	140331728	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:140331728G>A	uc004cmw.2	-	4	462	c.278C>T	c.(277-279)GCA>GTA	p.A93V	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Missense_Mutation_p.A93V|ENTPD8_uc004cmy.2_Missense_Mutation_p.A93V	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	93	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		ACCAGCCTGTGCAGCATTAGA	0.642												
NELF	26012	broad.mit.edu	37	9	140347017	140347017	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:140347017C>T	uc004cna.2	-	11	1385	c.1153G>A	c.(1153-1155)GAG>AAG	p.E385K	C9orf167_uc011mew.1_Intron|NELF_uc011mex.1_Missense_Mutation_p.E182K|NELF_uc010nci.2_Missense_Mutation_p.E129K|NELF_uc011mey.1_RNA|NELF_uc011mez.1_Missense_Mutation_p.E362K|NELF_uc004cmz.2_Missense_Mutation_p.E383K|NELF_uc004cnc.2_Missense_Mutation_p.E360K|NELF_uc004cnb.2_Missense_Mutation_p.E355K	NM_001130969	NP_001124441	Q6X4W1	NELF_HUMAN	nasal embryonic LHRH factor isoform a	385						nucleus|plasma membrane					0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000222)|Epithelial(140;0.000888)		AGGATGTCCTCGAAGGTTGCG	0.657												
PNPLA7	375775	broad.mit.edu	37	9	140392668	140392668	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:140392668A>G	uc004cnf.2	-	16	2049	c.1712T>C	c.(1711-1713)CTG>CCG	p.L571P	C9orf167_uc011mew.1_Intron|PNPLA7_uc011mfa.1_Intron|PNPLA7_uc010ncj.1_Missense_Mutation_p.L596P	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	571	cNMP 2.				lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		CGCCACACCCAGGACGACGGT	0.637												
EHMT1	79813	broad.mit.edu	37	9	140676805	140676805	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:140676805G>A	uc011mfc.1	+	15	2375	c.2338G>A	c.(2338-2340)GCG>ACG	p.A780T	EHMT1_uc004coa.2_Missense_Mutation_p.A780T|EHMT1_uc004cob.1_Missense_Mutation_p.A749T	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	780	ANK 2.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		ACTGCACGCCGCGGCAGAGGC	0.522												
IL3RA	3563	broad.mit.edu	37	X	1471117	1471117	+	Silent	SNP	C	C	T	rs142385163	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:1471117C>T	uc004cps.2	+	5	772	c.423C>T	c.(421-423)AAC>AAT	p.N141N	IL3RA_uc011mhd.1_Silent_p.N63N	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	141	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGTACTTGAACGTTGCCAAGT	0.647												
SFRS17A	8227	broad.mit.edu	37	X	1712726	1712726	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:1712726G>A	uc004cqa.2	+	2	567	c.371G>A	c.(370-372)CGC>CAC	p.R124H	SFRS17A_uc010ncx.1_Missense_Mutation_p.R124H|SFRS17A_uc004cqb.2_RNA|ASMT_uc004cqd.2_5'Flank	NM_005088	NP_005079	Q02040	AK17A_HUMAN	DNA segment on chromosome X and Y (unique) 155	124					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTCCCCACCCGCCACGACTGG	0.647												
ARSD	414	broad.mit.edu	37	X	2825515	2825515	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:2825515G>A	uc004cqy.2	-	10	1655	c.1579C>T	c.(1579-1581)CGG>TGG	p.R527W	ARSD_uc004cqz.1_RNA	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	527						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTCAGGGGCCGTGCCTCGGAG	0.687												
MXRA5	25878	broad.mit.edu	37	X	3240641	3240641	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:3240641G>T	uc004crg.3	-	5	3242	c.3085C>A	c.(3085-3087)CCA>ACA	p.P1029T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1029						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GATTGGCCTGGGACACCTGGT	0.443												
SHROOM2	357	broad.mit.edu	37	X	9914758	9914758	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:9914758C>T	uc004csu.1	+	10	4722	c.4632C>T	c.(4630-4632)GAC>GAT	p.D1544D	SHROOM2_uc004csv.2_Silent_p.D378D|SHROOM2_uc011mic.1_Silent_p.D379D|SHROOM2_uc004csw.1_Silent_p.D379D	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1544	ASD2.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				AGCACGAGGACGCCAAGGAGC	0.557												
FRMPD4	9758	broad.mit.edu	37	X	12722594	12722594	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:12722594C>T	uc004cuz.1	+	11	1693	c.1187C>T	c.(1186-1188)CCG>CTG	p.P396L	FRMPD4_uc011mij.1_Missense_Mutation_p.P388L	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	396	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						TTGGTACCACCGGGTAAAAAG	0.338												
TLR8	51311	broad.mit.edu	37	X	12939203	12939203	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:12939203A>G	uc004cve.2	+	2	2112	c.2044A>G	c.(2044-2046)ACA>GCA	p.T682A	TLR8_uc004cvd.2_Missense_Mutation_p.T700A	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	682	Extracellular (Potential).|LRR 20.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TTTTAACTGGACATTACTCCA	0.378												
ACE2	59272	broad.mit.edu	37	X	15607507	15607507	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:15607507C>T	uc004cxa.1	-	5	824	c.656G>A	c.(655-657)CGC>CAC	p.R219H	ACE2_uc004cxb.2_Missense_Mutation_p.R219H	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	219	Extracellular (Potential).			R->D: No effect on interaction with SARS- CoV spike glycoprotein.	angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	CAACTGGCCGCGGCTGTAGTC	0.423												
CTPS2	56474	broad.mit.edu	37	X	16720886	16720886	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:16720886G>A	uc004cxk.2	-	2	884	c.140C>T	c.(139-141)GCT>GTT	p.A47V	CTPS2_uc004cxl.2_Missense_Mutation_p.A47V|CTPS2_uc004cxm.2_Missense_Mutation_p.A47V	NM_001144002	NP_001137474	Q9NRF8	PYRG2_HUMAN	cytidine triphosphate synthase II	47					glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			ovary(1)	1	Hepatocellular(33;0.0997)					AAAAGTGCCAGCATCGATGTT	0.418												
CDKL5	6792	broad.mit.edu	37	X	18622107	18622107	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:18622107C>T	uc004cym.2	+	12	1316	c.1063C>T	c.(1063-1065)CGG>TGG	p.R355W	CDKL5_uc004cyn.2_Missense_Mutation_p.R355W	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	355					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					AGGCCTGCCCCGGGCTGACGA	0.493												
KLHL34	257240	broad.mit.edu	37	X	21674083	21674083	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:21674083C>T	uc004czz.1	-	1	2366	c.1824G>A	c.(1822-1824)GCG>GCA	p.A608A		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	608	Kelch 6.									ovary(1)	1						CCCAGGGCAACGCGCAGCCGA	0.692												
MAGEB6	158809	broad.mit.edu	37	X	26212473	26212473	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:26212473C>T	uc004dbr.2	+	2	659	c.510C>T	c.(508-510)GCC>GCT	p.A170A	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	170										ovary(3)	3						ATGTGGCTGCCGAGGGTGAAG	0.517												
FAM47A	158724	broad.mit.edu	37	X	34149285	34149285	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:34149285G>A	uc004ddg.2	-	1	1144	c.1111C>T	c.(1111-1113)CGG>TGG	p.R371W		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	371										ovary(4)|central_nervous_system(1)	5						CTGGACCCCCGACGAGTCTTG	0.642												
FAM47B	170062	broad.mit.edu	37	X	34962859	34962859	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:34962859C>T	uc004ddi.1	+	1	1929	c.1911C>T	c.(1909-1911)GAC>GAT	p.D637D		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	637										ovary(3)|breast(1)	4						ACAAAGAAGACGTCACAGATG	0.378												
USP9X	8239	broad.mit.edu	37	X	40996215	40996215	+	Silent	SNP	A	A	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:40996215A>G	uc004dfb.2	+	6	1227	c.594A>G	c.(592-594)TCA>TCG	p.S198S	USP9X_uc004dfc.2_Silent_p.S198S	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	198					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						CAGTTTCCTCAAGTGTTCAGT	0.378												
RGN	9104	broad.mit.edu	37	X	46943850	46943850	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:46943850C>T	uc004dgz.1	+	4	1166	c.197C>T	c.(196-198)TCG>TTG	p.S66L	RGN_uc004dha.1_Missense_Mutation_p.S66L|RGN_uc010nho.1_Missense_Mutation_p.S13L|RGN_uc010nhp.1_Missense_Mutation_p.S66L	NM_152869	NP_690608	Q15493	RGN_HUMAN	regucalcin	66					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding				0						CTTCGCCAGTCGGGAGGCTAT	0.483												
SSX5	6758	broad.mit.edu	37	X	48053565	48053565	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:48053565C>A	uc004dja.1	-	4	333	c.280G>T	c.(280-282)GTT>TTT	p.V94F	SSX5_uc004diz.1_Missense_Mutation_p.V135F	NM_175723	NP_783729	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5 isoform b	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						ATCTACTCACCCTGATTCCCA	0.493												
TBC1D25	4943	broad.mit.edu	37	X	48399811	48399811	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:48399811C>T	uc004dka.1	+	2	325	c.214C>T	c.(214-216)CGA>TGA	p.R72*	TBC1D25_uc011mly.1_5'UTR|TBC1D25_uc004dkb.1_5'UTR|TBC1D25_uc011mlz.1_Intron|TBC1D25_uc011mma.1_5'UTR|TBC1D25_uc004dkc.1_5'UTR|TBC1D25_uc011mmb.1_Nonsense_Mutation_p.R76*|TBC1D25_uc011mmc.1_5'UTR|TBC1D25_uc011mmd.1_5'UTR	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	72						intracellular	Rab GTPase activator activity			ovary(1)	1						CATCCTCATCCGAGCCTTTGA	0.552												
PQBP1	10084	broad.mit.edu	37	X	48759706	48759706	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:48759706C>T	uc004dle.2	+	5	678	c.489C>T	c.(487-489)CGC>CGT	p.R163R	PQBP1_uc004dlf.2_Silent_p.R163R|PQBP1_uc004dlg.2_Silent_p.R163R|PQBP1_uc004dld.2_Intron|PQBP1_uc004dlh.2_Silent_p.R163R|PQBP1_uc004dli.2_Silent_p.R163R|PQBP1_uc004dlj.1_Silent_p.R163R|PQBP1_uc004dln.2_Silent_p.R163R|PQBP1_uc010nih.2_RNA|PQBP1_uc010nii.2_Silent_p.R121R|PQBP1_uc004dlk.2_Intron|PQBP1_uc004dll.2_Intron|PQBP1_uc004dlm.2_Silent_p.R121R|PQBP1_uc010nij.2_Intron	NM_001032382	NP_001027554	O60828	PQBP1_HUMAN	polyglutamine binding protein 1	163	Arg-rich.|3-7.|7 X 2 AA tandem repeats of [DE]-R.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|transcription coactivator activity			large_intestine(1)	1						ATCGGGACCGCGGGTATGACA	0.612												
SYP	6855	broad.mit.edu	37	X	49049793	49049793	+	Missense_Mutation	SNP	C	C	T	rs150959416		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:49049793C>T	uc004dmz.1	-	5	567	c.551G>A	c.(550-552)CGC>CAC	p.R184H	SYP_uc011mmz.1_Missense_Mutation_p.R66H|SYP_uc004dna.1_Missense_Mutation_p.R178H	NM_003179	NP_003170	P08247	SYPH_HUMAN	synaptophysin	184	Vesicular (Potential).|MARVEL.				regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle maturation|synaptic vesicle membrane organization	cell junction|integral to synaptic vesicle membrane|synaptosome	calcium ion binding|cholesterol binding|transporter activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(315;0.00016)				CCCTGTCTGGCGGCAGACAGG	0.577												
GPR173	54328	broad.mit.edu	37	X	53106173	53106173	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:53106173G>A	uc004dru.2	+	2	628	c.370G>A	c.(370-372)GCC>ACC	p.A124T		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	124	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CCGCTACATGGCCATCGCCCA	0.592												
HUWE1	10075	broad.mit.edu	37	X	53587313	53587313	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:53587313G>A	uc004dsp.2	-	56	7974	c.7572C>T	c.(7570-7572)GAC>GAT	p.D2524D	HUWE1_uc004dsn.2_Silent_p.D1348D	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2524					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GAGAACTGTGGTCTGCATGGC	0.552												
HUWE1	10075	broad.mit.edu	37	X	53589102	53589102	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:53589102C>T	uc004dsp.2	-	54	7710	c.7308G>A	c.(7306-7308)GAG>GAA	p.E2436E	HUWE1_uc004dsn.2_Silent_p.E1260E	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	2436	Asp-rich.|Glu-rich.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						cctcctcctcctcctcttcat	0.428												
MAGED2	10916	broad.mit.edu	37	X	54841883	54841883	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:54841883G>A	uc004dtk.1	+	12	1683	c.1589G>A	c.(1588-1590)CGG>CAG	p.R530Q	MAGED2_uc004dtl.1_Missense_Mutation_p.R530Q|MAGED2_uc004dtm.1_Missense_Mutation_p.R445Q|MAGED2_uc010nkc.1_Intron|MAGED2_uc004dtn.1_Missense_Mutation_p.R530Q|MAGED2_uc004dto.1_Missense_Mutation_p.R504Q	NM_177433	NP_803182	Q9UNF1	MAGD2_HUMAN	melanoma antigen family D, 2	530										ovary(2)|breast(1)	3						GCCAAAGCCCGGATCCAGGCG	0.448												
TRO	7216	broad.mit.edu	37	X	54957360	54957360	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:54957360C>T	uc004dtq.2	+	12	4310	c.4203C>T	c.(4201-4203)AAC>AAT	p.N1401N	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_RNA|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Silent_p.N932N|TRO_uc004dtw.2_Silent_p.N1004N|TRO_uc004dtx.2_Silent_p.N784N	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1401	60; approximate.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GTGGACCAAACACTGGTGCTG	0.617												
USP51	158880	broad.mit.edu	37	X	55514444	55514444	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:55514444C>G	uc004dun.1	-	2	1008	c.929G>C	c.(928-930)AGA>ACA	p.R310T	USP51_uc011moo.1_Intron	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	310					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						AGTTAATAATCTCAAAATTTT	0.358												
OPHN1	4983	broad.mit.edu	37	X	67293039	67293039	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:67293039G>A	uc004dww.3	-	20	2083	c.1789C>T	c.(1789-1791)CGA>TGA	p.R597*	OPHN1_uc011mpg.1_Nonsense_Mutation_p.R597*	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	597					axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						GTCCTTTCTCGCAGCAAGCGC	0.498												
NLGN3	54413	broad.mit.edu	37	X	70389754	70389754	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:70389754G>A	uc004dzb.2	+	7	2598	c.2294G>A	c.(2293-2295)CGC>CAC	p.R765H	NLGN3_uc004dzc.2_Missense_Mutation_p.R648H|NLGN3_uc011mps.1_Missense_Mutation_p.R745H|NLGN3_uc004dze.2_Missense_Mutation_p.R583H	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	785	Cytoplasmic (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					GACACGCTGCGCCTCACTGCA	0.647												
ACRC	93953	broad.mit.edu	37	X	70823624	70823624	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:70823624C>T	uc004eae.2	+	8	998	c.497C>T	c.(496-498)TCG>TTG	p.S166L	BCYRN1_uc011mpt.1_Intron	NM_052957	NP_443189	Q96QF7	ACRC_HUMAN	ACRC protein	166	Asp/Ser-rich.					nucleus				ovary(3)	3	Renal(35;0.156)					AGTGATGATTCGGAAGCTCCC	0.498												
HDAC8	55869	broad.mit.edu	37	X	71681927	71681927	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:71681927G>A	uc004eau.2	-	9	974	c.932C>T	c.(931-933)ACG>ATG	p.T311M	HDAC8_uc011mqe.1_Missense_Mutation_p.T168M|HDAC8_uc011mqf.1_Missense_Mutation_p.T116M|HDAC8_uc011mqg.1_Missense_Mutation_p.T220M	NM_018486	NP_060956	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	311	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)	GCATCGAGCCGTGTTGGCAAG	0.478												
ZCCHC13	389874	broad.mit.edu	37	X	73524363	73524363	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:73524363C>T	uc004ebs.3	+	1	339	c.262C>T	c.(262-264)CGC>TGC	p.R88C		NM_203303	NP_976048	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	88							nucleic acid binding|zinc ion binding				0						ACGAGAGAGACGCCAACACTG	0.498												
KIAA2022	340533	broad.mit.edu	37	X	73961202	73961202	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:73961202G>A	uc004eby.2	-	3	3807	c.3190C>T	c.(3190-3192)CGC>TGC	p.R1064C		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1064					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GAAGAGTGGCGGAATTTGTCA	0.493												
MAGEE1	57692	broad.mit.edu	37	X	75650737	75650737	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:75650737T>G	uc004ecm.1	+	1	2621	c.2414T>G	c.(2413-2415)CTT>CGT	p.L805R		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	805	Interaction with DTNA (By similarity).|MAGE 2.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						CTAGTGGTACTTGATCCCAGG	0.502												
TBX22	50945	broad.mit.edu	37	X	79279656	79279656	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:79279656C>T	uc010nmg.1	+	4	585	c.451C>T	c.(451-453)CGC>TGC	p.R151C	TBX22_uc004edi.1_Missense_Mutation_p.R31C|TBX22_uc004edj.1_Missense_Mutation_p.R151C	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	151	T-box.				multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						GGATTCCAAACGCTATAGGTA	0.527												
BRWD3	254065	broad.mit.edu	37	X	79980463	79980463	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:79980463C>T	uc004edt.2	-	15	1753	c.1490G>A	c.(1489-1491)CGG>CAG	p.R497Q	BRWD3_uc004edo.2_Missense_Mutation_p.R93Q|BRWD3_uc004edp.2_Missense_Mutation_p.R326Q|BRWD3_uc004edq.2_Missense_Mutation_p.R93Q|BRWD3_uc010nmj.1_Missense_Mutation_p.R93Q|BRWD3_uc004edr.2_Missense_Mutation_p.R167Q|BRWD3_uc004eds.2_Missense_Mutation_p.R93Q|BRWD3_uc004edu.2_Missense_Mutation_p.R167Q|BRWD3_uc004edv.2_Missense_Mutation_p.R93Q|BRWD3_uc004edw.2_Missense_Mutation_p.R93Q|BRWD3_uc004edx.2_Missense_Mutation_p.R93Q|BRWD3_uc004edy.2_Missense_Mutation_p.R93Q|BRWD3_uc004edz.2_Missense_Mutation_p.R167Q|BRWD3_uc004eea.2_Missense_Mutation_p.R167Q|BRWD3_uc004eeb.2_Missense_Mutation_p.R93Q	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	497	WD 8.									ovary(4)	4						TTTGGTCCCCCGGTCAAGGTC	0.373												
POU3F4	5456	broad.mit.edu	37	X	82764299	82764299	+	Missense_Mutation	SNP	C	C	T	rs104894924		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:82764299C>T	uc004eeg.2	+	1	1031	c.967C>T	c.(967-969)CGT>TGT	p.R323C		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	323	Homeobox.		R -> G (in DFNX2; somatic mosaicism in 50% of the peripheral blood lymphocytes).		sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGAAGTGGTGCGTGTCTGGTT	0.542												
NAP1L3	4675	broad.mit.edu	37	X	92927271	92927271	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:92927271G>T	uc004efq.2	-	1	1338	c.1033C>A	c.(1033-1035)CTG>ATG	p.L345M	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	345					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						GAGAACTTCAGGCTAACATCC	0.413												
PCDH19	57526	broad.mit.edu	37	X	99551449	99551449	+	Silent	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:99551449G>T	uc010nmz.2	-	6	4949	c.3273C>A	c.(3271-3273)GCC>GCA	p.A1091A	PCDH19_uc004efw.3_Silent_p.A1043A|PCDH19_uc004efx.3_Silent_p.A1044A	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	1091	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CCAGATCACGGGCTGGGGGAG	0.582												
XKRX	402415	broad.mit.edu	37	X	100169452	100169452	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:100169452G>A	uc004egn.2	-	3	1830	c.1225C>T	c.(1225-1227)CGC>TGC	p.R409C	XKRX_uc011mre.1_Missense_Mutation_p.R205C	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	409						integral to membrane|plasma membrane				breast(1)	1						AAGAGTGAGCGCAATGGATGC	0.468												
CENPI	2491	broad.mit.edu	37	X	100387216	100387216	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:100387216G>A	uc004egx.2	+	13	1595	c.1325G>A	c.(1324-1326)AGC>AAC	p.S442N	CENPI_uc011mrg.1_Missense_Mutation_p.S442N|CENPI_uc004egy.2_Missense_Mutation_p.S442N	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	442					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						CTGTATAAGAGCCTTCCTCTC	0.398												
HNRNPH2	3188	broad.mit.edu	37	X	100667790	100667790	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:100667790T>G	uc004ehm.2	+	2	984	c.814T>G	c.(814-816)TCT>GCT	p.S272A	HNRNPH2_uc004ehn.2_Missense_Mutation_p.S272A	NM_019597	NP_062543	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2	272	2 X 16 AA Gly-rich approximate repeats.				nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TTCAGGAATGTCTGATCATAG	0.453												
NXF5	55998	broad.mit.edu	37	X	101095488	101095488	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:101095488G>A	uc011mrk.1	-	10	1041	c.681C>T	c.(679-681)GAC>GAT	p.D227D	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	227	LRR 3.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						AGGCAGACTGGTCCGAGAAGG	0.577												
ZMAT1	84460	broad.mit.edu	37	X	101138866	101138866	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:101138866G>A	uc004eim.2	-	2	4518	c.1020C>T	c.(1018-1020)TAC>TAT	p.Y340Y	ZMAT1_uc011mrl.1_Silent_p.Y511Y|ZMAT1_uc004ein.2_Silent_p.Y340Y|ZMAT1_uc011mrm.1_Silent_p.Y340Y	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	340						nucleus	zinc ion binding			ovary(1)	1						ATTCTACACTGTATGAGCCAG	0.408												
FAM199X	139231	broad.mit.edu	37	X	103434329	103434329	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:103434329G>A	uc004elw.2	+	6	1203	c.1037G>A	c.(1036-1038)CGC>CAC	p.R346H	FAM199X_uc004elx.2_Missense_Mutation_p.R120H	NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	346										ovary(1)	1						AAGGCCTTCCGCAAGAGGCAG	0.488												
NRK	203447	broad.mit.edu	37	X	105153047	105153047	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:105153047C>T	uc004emd.2	+	13	1717	c.1414C>T	c.(1414-1416)CGG>TGG	p.R472W	NRK_uc010npc.1_Missense_Mutation_p.R140W	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	472	Gln-rich.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TCCACGACTACGGAGGGCAGC	0.557										HNSCC(51;0.14)		
CXorf57	55086	broad.mit.edu	37	X	105865880	105865880	+	Splice_Site	SNP	G	G	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:105865880G>C	uc004emi.3	+	2	795	c.644_splice	c.e2-1	p.D215_splice	CXorf57_uc004emj.3_Splice_Site_p.D215_splice|CXorf57_uc004emh.2_Splice_Site_p.D215_splice	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086											ovary(1)|lung(1)|breast(1)	3						TTATATTCTAGATACCAAAAT	0.308												
IRS4	8471	broad.mit.edu	37	X	107978724	107978724	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:107978724C>T	uc004eoc.2	-	1	884	c.851G>A	c.(850-852)CGC>CAC	p.R284H		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	284	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GTGTCCACAGCGACGGATGCT	0.592												
CHRDL1	91851	broad.mit.edu	37	X	109964646	109964646	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:109964646C>T	uc004eou.3	-	5	763	c.414G>A	c.(412-414)CGG>CGA	p.R138R	CHRDL1_uc004eov.2_Silent_p.R132R|CHRDL1_uc004eow.2_Silent_p.R137R|CHRDL1_uc010nps.2_Silent_p.R137R|CHRDL1_uc004eot.2_Intron|CHRDL1_uc011mss.1_Intron|CHRDL1_uc004eox.3_Silent_p.R131R	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	131	VWFC 2.				BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						GATTGGGTTGCCGATTCTGAA	0.483												
ALG13	79868	broad.mit.edu	37	X	110954936	110954936	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:110954936C>T	uc011msy.1	+	6	902	c.868C>T	c.(868-870)CGG>TGG	p.R290W	ALG13_uc011msw.1_Missense_Mutation_p.R212W|ALG13_uc011msx.1_Missense_Mutation_p.R186W|ALG13_uc011msz.1_Missense_Mutation_p.R212W|ALG13_uc011mta.1_Missense_Mutation_p.R186W|ALG13_uc011mtb.1_Missense_Mutation_p.R186W			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	290	OTU.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						ATACCTGGAACGGTTGGGAGA	0.308												
TRPC5	7224	broad.mit.edu	37	X	111090440	111090440	+	Silent	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:111090440T>C	uc004epl.1	-	6	2521	c.1602A>G	c.(1600-1602)GGA>GGG	p.G534G	TRPC5_uc004epm.1_Silent_p.G534G	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	534	Extracellular (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						GCTGGTTCAGTCCATTGGCAA	0.458												
HTR2C	3358	broad.mit.edu	37	X	113965896	113965896	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:113965896G>T	uc004epu.1	+	4	957	c.229G>T	c.(229-231)GCA>TCA	p.A77S	HTR2C_uc010nqc.1_Missense_Mutation_p.A77S|HTR2C_uc004epv.1_Missense_Mutation_p.A77S	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	77	Helical; Name=1; (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	TGTGATCATGGCAGTAAGCAT	0.448												
LRCH2	57631	broad.mit.edu	37	X	114419019	114419019	+	Silent	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:114419019T>A	uc010nqe.2	-	3	607	c.576A>T	c.(574-576)GTA>GTT	p.V192V	LRCH2_uc004epz.2_Silent_p.V192V	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	192	LRR 5.									ovary(1)	1						CTGGAATGGATACCAGTTTAT	0.303												
LRCH2	57631	broad.mit.edu	37	X	114422934	114422934	+	Splice_Site	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:114422934C>T	uc010nqe.2	-	2	381	c.350_splice	c.e2-1	p.D117_splice	LRCH2_uc004epz.2_Splice_Site_p.D117_splice|RBMXL3_uc011mte.1_5'Flank	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)											ovary(1)	1						CTGGAAAGATCTGAAAAGAAA	0.299												
FAM70A	55026	broad.mit.edu	37	X	119419025	119419025	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:119419025G>A	uc004eso.3	-	7	768	c.541C>T	c.(541-543)CGG>TGG	p.R181W	FAM70A_uc004esp.3_Missense_Mutation_p.R157W|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	181						integral to membrane				lung(1)|breast(1)	2						GTGTTGCCCCGGATGCGAGGT	0.527												
SASH3	54440	broad.mit.edu	37	X	128924995	128924995	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:128924995C>T	uc011mun.1	+	4	562	c.380C>T	c.(379-381)GCG>GTG	p.A127V	SASH3_uc004euu.2_Missense_Mutation_p.A127V|SASH3_uc011muo.1_Missense_Mutation_p.A44V	NM_018990	NP_061863	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	127										ovary(2)|pancreas(1)	3						GAGAAGATGGCGCTGGCCTTT	0.627												
ARHGAP36	158763	broad.mit.edu	37	X	130222706	130222706	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:130222706C>T	uc004evz.2	+	12	1936	c.1591C>T	c.(1591-1593)CGT>TGT	p.R531C	ARHGAP36_uc004ewa.2_Missense_Mutation_p.R519C|ARHGAP36_uc004ewb.2_Missense_Mutation_p.R500C|ARHGAP36_uc004ewc.2_Missense_Mutation_p.R395C	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	531					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						CCCATTGCTCCGTGTGCCCCG	0.582												
GPC4	2239	broad.mit.edu	37	X	132445391	132445391	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:132445391G>A	uc004exc.1	-	4	984	c.772C>T	c.(772-774)CGG>TGG	p.R258W	GPC4_uc011mvg.1_Missense_Mutation_p.R188W	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	258					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					ACGAGACCCCGGCAGTGGGAG	0.483												
FAM127A	8933	broad.mit.edu	37	X	134166473	134166473	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:134166473G>A	uc004eyd.2	+	1	141	c.60G>A	c.(58-60)ACG>ACA	p.T20T	uc004eye.1_RNA	NM_001078171	NP_001071639	A6ZKI3	F127A_HUMAN	family with sequence similarity 127, member A	20											0	Acute lymphoblastic leukemia(192;0.000127)					GGCCTGCGACGCGTCGCTGGA	0.642												
SAGE1	55511	broad.mit.edu	37	X	134989148	134989148	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:134989148A>C	uc004ezh.2	+	8	967	c.800A>C	c.(799-801)AAC>ACC	p.N267T	SAGE1_uc010nry.1_Missense_Mutation_p.N236T|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	267										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CAACCTGATAACATCTTGTCA	0.463												
MMGT1	93380	broad.mit.edu	37	X	135047268	135047268	+	Missense_Mutation	SNP	G	G	A	rs150859420		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:135047268G>A	uc004ezi.1	-	4	611	c.311C>T	c.(310-312)TCG>TTG	p.S104L	MMGT1_uc011mvw.1_Missense_Mutation_p.S169L	NM_173470	NP_775741	Q8N4V1	MMGT1_HUMAN	membrane magnesium transporter 1 precursor	104	Cytoplasmic (Potential).					early endosome membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	magnesium ion transmembrane transporter activity				0						TGCTGTATCCGAAGGCCGGAA	0.358												
ARHGEF6	9459	broad.mit.edu	37	X	135751673	135751673	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:135751673C>T	uc004fab.2	-	21	2620	c.2158G>A	c.(2158-2160)GCC>ACC	p.A720T	ARHGEF6_uc011mwd.1_Missense_Mutation_p.A593T|ARHGEF6_uc011mwe.1_Missense_Mutation_p.A566T	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	720					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					TCCTTCAAGGCGTAAACAGTA	0.368												
FGF13	2258	broad.mit.edu	37	X	137793063	137793063	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:137793063T>C	uc004fam.2	-	1	765	c.103A>G	c.(103-105)AAG>GAG	p.K35E	FGF13_uc004fan.2_Intron|FGF13_uc011mwi.1_Intron|FGF13_uc004faq.2_Intron|FGF13_uc004far.2_Intron|FGF13_uc011mwj.1_Intron|FGF13_uc011mwk.1_Intron|uc004fao.2_5'Flank	NM_004114	NP_004105	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 1	35					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CAGCTGGTCTTGCCTTTGCTG	0.567												
SPANXC	64663	broad.mit.edu	37	X	140335784	140335784	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:140335784G>A	uc004fbk.2	-	2	216	c.160C>T	c.(160-162)CGC>TGC	p.R54C	SPANXC_uc004fbl.2_RNA	NM_022661	NP_073152	Q9NY87	SPNXC_HUMAN	sperm protein associated with the nucleus, X	54						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					CTCCTGTAGCGAACCACTAGT	0.498												
SPANXN3	139067	broad.mit.edu	37	X	142605183	142605183	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:142605183T>A	uc004fbw.2	-	1	125	c.37A>T	c.(37-39)ACG>TCG	p.T13S		NM_001009609	NP_001009609	Q5MJ09	SPXN3_HUMAN	SPANX-N3 protein	13										ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGGCTCTTCGTCTTCTCCCCA	0.328												
CXorf1	9142	broad.mit.edu	37	X	144909328	144909328	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:144909328T>G	uc004fch.2	+	1	401	c.133T>G	c.(133-135)TTA>GTA	p.L45V		NM_004709	NP_004700	O96002	CX001_HUMAN	hypothetical protein LOC9142	45											0	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTTTTGCTTTATCTGCTCA	0.294												
ATP2B3	492	broad.mit.edu	37	X	152813442	152813442	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:152813442C>T	uc004fht.1	+	7	1234	c.1108C>T	c.(1108-1110)CAG>TAG	p.Q370*	ATP2B3_uc004fhs.1_Nonsense_Mutation_p.Q370*	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	370	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCTAGCCGTGCAGATCGGGAA	0.607												
SRPK3	26576	broad.mit.edu	37	X	153047269	153047269	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:153047269T>A	uc004fil.2	+	4	403	c.371T>A	c.(370-372)ATC>AAC	p.I124N	SRPK3_uc004fik.2_Missense_Mutation_p.I190N|SRPK3_uc010nul.2_Missense_Mutation_p.I82N|SRPK3_uc004fin.2_Missense_Mutation_p.I124N|SRPK3_uc004fim.2_Missense_Mutation_p.I124N	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	124	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGGATGAGATCAAGCTCCTG	0.617												
L1CAM	3897	broad.mit.edu	37	X	153128277	153128277	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:153128277G>A	uc004fjb.2	-	28	3723	c.3615C>T	c.(3613-3615)GAC>GAT	p.D1205D	L1CAM_uc004fjc.2_Silent_p.D1201D|L1CAM_uc010nuo.2_Silent_p.D1196D	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1205	Cytoplasmic (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGGCTGTCGTCACTGCCCA	0.602												
RENBP	5973	broad.mit.edu	37	X	153207102	153207102	+	Silent	SNP	G	G	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:153207102G>A	uc004fjo.1	-	8	944	c.774C>T	c.(772-774)CAC>CAT	p.H258H	RENBP_uc011mzh.1_Missense_Mutation_p.T231I	NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	258					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	CTTCCAGCGTGTGGCCTGGTG	0.627												
FLNA	2316	broad.mit.edu	37	X	153581719	153581719	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:153581719C>T	uc004fkk.2	-	37	6216	c.5967G>A	c.(5965-5967)CCG>CCA	p.P1989P	FLNA_uc004fki.2_Silent_p.P32P|FLNA_uc011mzn.1_Silent_p.P122P|FLNA_uc010nuu.1_Silent_p.P1981P	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	1989	Filamin 18.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGCCCGAGGGCGGGACCACAG	0.627												
GDI1	2664	broad.mit.edu	37	X	153669509	153669509	+	Silent	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:153669509C>T	uc004fli.3	+	7	1128	c.786C>T	c.(784-786)AAC>AAT	p.N262N	GDI1_uc011mzo.1_3'UTR|GDI1_uc004flj.2_5'Flank|FAM50A_uc004fll.3_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	262					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCATGGAGAACGGCAAGGTGG	0.572												
FAM50A	9130	broad.mit.edu	37	X	153678623	153678623	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:153678623C>T	uc004fll.3	+	12	1065	c.967C>T	c.(967-969)CGC>TGC	p.R323C		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	323					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCCGCCAGCCGCTGGGAACC	0.627												
PLXNA3	55558	broad.mit.edu	37	X	153689602	153689602	+	Missense_Mutation	SNP	C	C	T	rs147390702	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:153689602C>T	uc004flm.2	+	3	931	c.758C>T	c.(757-759)GCG>GTG	p.A253V		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	253	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTGGACACAGCGGGCGAGAAA	0.577												
LAGE3	8270	broad.mit.edu	37	X	153706395	153706395	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:153706395C>T	uc004fln.1	-	3	662	c.320G>A	c.(319-321)CGC>CAC	p.R107H		NM_006014	NP_006005	Q14657	LAGE3_HUMAN	L antigen family, member 3	107							protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGCTTTCCAGCGGCTAAAAGT	0.562												
RAB39B	116442	broad.mit.edu	37	X	154490449	154490449	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:154490449C>T	uc004fne.2	-	2	560	c.281G>A	c.(280-282)CGC>CAC	p.R94H		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	94					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GAAGGACCTGCGGTTGGTAAT	0.448												
GPR64	10149	broad.mit.edu	37	X	19046358	19046359	+	Splice_Site	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:19046358_19046359insA	uc004cyx.2	-	10	523	c.359_splice	c.e10-1	p.A120_splice	GPR64_uc004cyy.2_Splice_Site_p.A117_splice|GPR64_uc004cyz.2_Splice_Site_p.A106_splice|GPR64_uc004czb.2_Splice_Site_p.A120_splice|GPR64_uc004czc.2_Splice_Site_p.A104_splice|GPR64_uc004czd.2_Splice_Site_p.A96_splice|GPR64_uc004cze.2_Splice_Site_p.A90_splice|GPR64_uc004czf.2_Splice_Site_p.A82_splice|GPR64_uc004cza.2_Splice_Site_p.A98_splice|GPR64_uc004cyw.2_Splice_Site_p.A104_splice|GPR64_uc010nfj.2_Splice_Site_p.A90_splice	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1						neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					TAAAAAATGCTAAAAATAAATT	0.262												
C2orf42	54980	broad.mit.edu	37	2	70406777	70406777	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:70406776_70406776TA>T	uc002sgh.3	-	4	1152	c.824_splice	c.e4-1	p.G275_splice		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	Homo sapiens chromosome 2 open reading frame 42 (C2orf42), mRNA.	275										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						CTTTAAGACCTAAAAAAAAGA	0.353												
SCRN3	79634	broad.mit.edu	37	2	175263005	175263005	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:175263004_175263004TA>T	uc002uiq.3	+	2	90	c.-8_splice	c.e2-1		CIR1_uc002uim.3_5'Flank|CIR1_uc002uin.3_5'Flank|SCRN3_uc010zen.2_Intron|SCRN3_uc010zeo.2_Splice_Site|SCRN3_uc002uir.1_Splice_Site	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	Homo sapiens secernin 3 (SCRN3), transcript variant 1, mRNA.						proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			AATTTTTAGTTAAAAAAAATG	0.279												
GTF3C3	9330	broad.mit.edu	37	2	197650315	197650315	+	Splice_Site	DEL	A	A	-	rs35643383		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:197650314_197650314TA>T	uc002uts.3	-	7	1051	c.894_splice	c.e7-1	p.K298_splice	GTF3C3_uc010zgu.2_Splice_Site_p.K298_splice|GTF3C3_uc002utu.3_Splice_Site_p.K298_splice|GTF3C3_uc002utt.4_Splice_Site	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	Homo sapiens general transcription factor IIIC, polypeptide 3, 102kDa (GTF3C3), transcript variant 1, mRNA.	298						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TAGTAACTCCTAAAAAAAAGT	0.323												
ERBB4	2066	broad.mit.edu	37	2	212288881	212288882	+	Splice_Site	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:212288880_212288881A>AT	uc002veg.1	-	23	2964	c.2866_splice	c.e23+1	p.C956_splice	ERBB4_uc002veh.1_Splice_Site_p.C956_splice|ERBB4_uc010zji.1_Splice_Site_p.C946_splice|ERBB4_uc010zjj.1_Splice_Site_p.C946_splice	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	Homo sapiens v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1, mRNA.	956	Protein kinase.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GCAGTCTTACATTTGACCATGA	0.366										TSP Lung(8;0.080)		
SCN11A	11280	broad.mit.edu	37	3	38949441	38949442	+	Splice_Site	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:38949440_38949441C>CT	uc021wvy.1	-	10	1672	c.1473_splice	c.e10+1	p.K491_splice		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	Homo sapiens sodium channel, voltage-gated, type XI, alpha subunit (SCN11A), mRNA.	491					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAAGACTTACCTTTTTTTGGCA	0.386												
FYB	2533	broad.mit.edu	37	5	39124357	39124358	+	Splice_Site	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:39124356_39124357C>CA	uc003jls.3	-	11	2000	c.1933_splice	c.e11+1	p.D645_splice	FYB_uc003jlt.3_Splice_Site_p.D691_splice|FYB_uc003jlu.3_Splice_Site_p.D645_splice|FYB_uc011cpl.2_Splice_Site_p.D701_splice	NM_199335	NP_955367	O15117	FYB_HUMAN	Homo sapiens FYN binding protein (FYB), transcript variant 2, mRNA.	645					NLS-bearing substrate import into nucleus|T cell receptor signaling pathway|cell junction assembly|immune response|intracellular protein kinase cascade|protein phosphorylation	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			ATTACTTACCCAATTGTTTAGG	0.351												
LARS	51520	broad.mit.edu	37	5	145508683	145508683	+	Splice_Site	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:145508682_145508682CT>C	uc003lnx.1	-	26	2867	c.2629_splice	c.e26-1	p.P877_splice	LARS_uc003lnw.1_Splice_Site_p.P35_splice|LARS_uc011dbq.1_Splice_Site_p.P831_splice|LARS_uc011dbr.1_Splice_Site_p.P823_splice|LARS_uc011dbs.1_Splice_Site_p.P850_splice	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	Homo sapiens leucyl-tRNA synthetase (LARS), mRNA.	877					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TTGAGTCAGGCTTTTAAAAAA	0.333												
DTNBP1	84062	broad.mit.edu	37	6	15638038	15638038	+	Splice_Site	DEL	A	A	-	rs140124163		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:15638037_15638037TA>T	uc003nbm.3	-	4	351	c.162_splice	c.e4-1	p.R54_splice	DTNBP1_uc003nbl.3_Splice_Site|DTNBP1_uc010jph.3_Splice_Site_p.R41_splice|DTNBP1_uc003nbp.3_Splice_Site_p.R54_splice	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	Homo sapiens dystrobrevin binding protein 1 (DTNBP1), transcript variant 1, mRNA.	54					actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	BLOC-1 complex|axon part|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	14	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			TCCTCATACCTAAAAAAAAGC	0.363									Hermansky-Pudlak syndrome			
C9orf11	54586	broad.mit.edu	37	9	27296739	27296739	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:27296738_27296738TA>T	uc003zql.3	-	2	161	c.77_splice	c.e2-1	p.A26_splice	C9orf11_uc011lnq.2_Splice_Site_p.A26_splice|C9orf11_uc003zqm.3_Splice_Site_p.A26_splice	NM_020641	NP_065692	Q9NQ60	AFAF_HUMAN	Homo sapiens chromosome 9 open reading frame 11 (C9orf11), transcript variant 1, mRNA.	26						acrosomal membrane|integral to membrane				breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	17				OV - Ovarian serous cystadenocarcinoma(39;7.39e-08)|Lung(218;1.26e-05)|LUSC - Lung squamous cell carcinoma(38;0.000106)		TAGGCAATGCTAAAAAAAAGT	0.323												
RNF38	152006	broad.mit.edu	37	9	36342424	36342424	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:36342423_36342423TA>T	uc003zzh.3	-	11	1577	c.1386_splice	c.e11-1	p.L462_splice	RNF38_uc003zzi.3_Splice_Site_p.L412_splice|RNF38_uc003zzj.3_Splice_Site_p.L379_splice|RNF38_uc003zzk.3_Splice_Site_p.L379_splice|RNF38_uc003zzl.3_Splice_Site_p.L386_splice|RNF38_uc003zzm.3_Splice_Site_p.L379_splice	NM_022781	NP_919313	Q9H0F5	RNF38_HUMAN	Homo sapiens ring finger protein 38 (RNF38), transcript variant 1, mRNA.	462							zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			ACTACACACCTAAAAAAAGCA	0.358												
FUBP3	8939	broad.mit.edu	37	9	133506014	133506015	+	Splice_Site	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:133506013_133506014A>AG	uc004bzr.1	+	13	1226	c.1118_splice	c.e13-1	p.G373_splice		NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	Homo sapiens far upstream element (FUSE) binding protein 3 (FUBP3), mRNA.	373	KH 4.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		TGCTGTCCGCAGGGGGTGAGAA	0.589												
KIN	22944	broad.mit.edu	37	10	7817765	7817765	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:7817764_7817764TA>T	uc001ijt.3	-	6	653	c.559_splice	c.e6-1	p.E187_splice	KIN_uc010qaz.2_Splice_Site|KIN_uc010qba.2_Splice_Site_p.E81_splice	NM_012311	NP_036443	O60870	KIN17_HUMAN	Homo sapiens KIN, antigenic determinant of recA protein homolog (mouse) (KIN), transcript variant 1, mRNA.	187					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	RNA binding|double-stranded DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						AGGGACCTCCTAAAAAAAAGA	0.318												
TALDO1	6888	broad.mit.edu	37	11	755877	755885	+	Splice_Site	DEL	AGCCATCGA	AGCCATCGA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:755876_755884TAGCCATCGA>T	uc001lqz.3	+	2	148	c.98_splice	c.e2-1	p.A33_splice	TALDO1_uc010qwl.2_Splice_Site_p.A33_splice|TALDO1_uc001lra.3_Splice_Site_p.A33_splice	NM_006755	NP_006746	P37837	TALDO_HUMAN	Homo sapiens transaldolase 1 (TALDO1), mRNA.	33					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		ACTATTTCCCTAGCCATCGACGAGTACAA	0.541												
ATL3	25923	broad.mit.edu	37	11	63420050	63420050	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:63420049_63420049TA>T	uc001nxk.1	-	4	682	c.406_splice	c.e4-1	p.V136_splice	ATL3_uc010rms.1_Splice_Site_p.V118_splice	NM_015459	NP_056274	Q6DD88	ATLA3_HUMAN	Homo sapiens atlastin GTPase 3 (ATL3), mRNA.	136					Golgi organization|endoplasmic reticulum organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	11						AACTGCAACCTAAAAAAAAGG	0.373												
DDX6	1656	broad.mit.edu	37	11	118629614	118629614	+	Splice_Site	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:118629613_118629613TG>T	uc001pub.2	-	9	1226	c.865_splice	c.e9-1	p.N289_splice	DDX6_uc001pua.2_5'UTR|DDX6_uc001puc.2_Splice_Site_p.N289_splice	NM_004397	NP_004388	P26196	DDX6_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 (DDX6), mRNA.	289	Helicase ATP-binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	RNA-induced silencing complex|cytoplasmic mRNA processing body|cytosol|stress granule	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|protein binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		ATGGGAATTCTGGGGGGGGAG	0.423			T	IGH@	B-NHL							
PXN	5829	broad.mit.edu	37	12	120657167	120657168	+	RNA	INS	-	-	C	rs61741284		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:120657166_120657167T>TC	uc001tya.3	-	0		c.754_755A>GA			PXN_uc001txu.3_5'Flank|PXN_uc001txx.3_Intron|PXN_uc001txt.3_Intron|PXN_uc001txv.3_Intron|PXN_uc001txy.3_Intron|PXN_uc001txz.3_Non-coding_Transcript			P49023	PAXI_HUMAN	Homo sapiens cDNA: FLJ23042 fis, clone LNG02323.						cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGCCACACTTCCCCTCTCGGT	0.634												
HERC2	8924	broad.mit.edu	37	15	28366578	28366578	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:28366577_28366577TA>T	uc001zbj.3	-	86	13295	c.13189_splice	c.e86-1	p.E4397_splice		NM_004667	NP_004658	O95714	HERC2_HUMAN	Homo sapiens hect domain and RLD 2 (HERC2), mRNA.	4397					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGCCGCCTCCTAAAACACATC	0.438												
HERC2	8924	broad.mit.edu	37	15	28463820	28463820	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:28463819_28463819TA>T	uc001zbj.3	-	38	5952	c.5846_splice	c.e38-1	p.E1949_splice		NM_004667	NP_004658	O95714	HERC2_HUMAN	Homo sapiens hect domain and RLD 2 (HERC2), mRNA.	1949					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTTCGGCTTCTAAAAAAAATA	0.333												
CACNA1H	8912	broad.mit.edu	37	16	1260974	1260974	+	Splice_Site	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:1260973_1260973TG>T	uc002cks.3	+	21	4471	c.4223_splice	c.e21+2	p.R1408_splice	CACNA1H_uc002ckt.3_Splice_Site_p.R1408_splice|CACNA1H_uc002cku.3_Splice_Site_p.R114_splice|CACNA1H_uc010brj.3_Splice_Site_p.R114_splice|CACNA1H_uc002ckv.3_Splice_Site_p.R114_splice	NM_021098	NP_066921	O95180	CAC1H_HUMAN	Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit (CACNA1H), transcript variant 1, mRNA.	1408					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCCTCTGAGGTGGGGGGCTCC	0.697												
ZC3H7A	29066	broad.mit.edu	37	16	11873222	11873222	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:11873221_11873221TA>T	uc002dbk.3	-	3	307	c.109_splice	c.e3-1	p.V37_splice	ZC3H7A_uc002dbl.3_Splice_Site_p.V37_splice|ZC3H7A_uc002dbm.2_Splice_Site_p.V37_splice	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	Homo sapiens zinc finger CCCH-type containing 7A (ZC3H7A), mRNA.	37						nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						CAAATATACCTAAAAAAAAGA	0.338												
ARHGAP17	55114	broad.mit.edu	37	16	24958802	24958802	+	Splice_Site	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:24958801_24958801AC>A	uc002dnb.3	-	14	1334	c.1241_splice	c.e14+1	p.G414_splice	ARHGAP17_uc002dna.3_Splice_Site_p.G141_splice|ARHGAP17_uc002dnc.3_Splice_Site_p.G414_splice|ARHGAP17_uc010vcf.2_Splice_Site_p.G235_splice	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	Homo sapiens Rho GTPase activating protein 17 (ARHGAP17), transcript variant 1, mRNA.	414	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		AAGATGACTTACCCTTCATTT	0.403												
ATP6V0A1	535	broad.mit.edu	37	17	40642658	40642658	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:40642657_40642657TA>T	uc002hzs.3	+	11	1362	c.1195_splice	c.e11+2	p.A399_splice	ATP6V0A1_uc002hzr.3_Splice_Site_p.A392_splice|ATP6V0A1_uc002hzq.3_Splice_Site_p.A392_splice|ATP6V0A1_uc010wgj.2_Splice_Site_p.A349_splice|ATP6V0A1_uc010wgk.2_Splice_Site_p.A349_splice|ATP6V0A1_uc010cyg.3_Splice_Site_p.A38_splice|ATP6V0A1_uc010wgl.2_Splice_Site_p.A251_splice	NM_001130020	NP_001123492	Q93050	VPP1_HUMAN	Homo sapiens ATPase, H+ transporting, lysosomal V0 subunit a1 (ATP6V0A1), transcript variant 1, mRNA.	392					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	Golgi apparatus|cytoplasmic vesicle membrane|endosome membrane|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TAAATCCAGGTAAAAAAAAGC	0.388												
PSTPIP2	9050	broad.mit.edu	37	18	43595906	43595906	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:43595905_43595905TA>T	uc002lbp.4	-	4	309	c.213_splice	c.e4-1	p.N71_splice	PSTPIP2_uc002lbq.4_Splice_Site_p.N71_splice	NM_024430	NP_077748	Q9H939	PPIP2_HUMAN	Homo sapiens proline-serine-threonine phosphatase interacting protein 2 (PSTPIP2), mRNA.	71	FCH.					membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	17						TTCAGGGTGCTAAAAAAAACA	0.383												
GPR64	10149	broad.mit.edu	37	X	19046359	19046360	+	Splice_Site	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:19046358_19046359T>TA	uc004cyx.3	-	10	601	c.359_splice	c.e10-1	p.A120_splice	GPR64_uc004cze.3_Splice_Site_p.A90_splice|GPR64_uc004cza.3_Splice_Site_p.A98_splice|GPR64_uc004czf.3_Splice_Site_p.A82_splice|GPR64_uc004cyy.3_Splice_Site_p.A117_splice|GPR64_uc004czc.3_Splice_Site_p.A104_splice|GPR64_uc004cyz.3_Splice_Site_p.A106_splice|GPR64_uc004czb.3_Splice_Site_p.A120_splice|GPR64_uc004czd.3_Splice_Site_p.A96_splice|GPR64_uc004cyw.3_Splice_Site_p.A104_splice|GPR64_uc010nfj.3_Splice_Site_p.A90_splice	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	Homo sapiens G protein-coupled receptor 64 (GPR64), transcript variant 1, mRNA.	120					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					TAAAAAATGCTAAAAATAAATT	0.262												
SPSB1	80176	broad.mit.edu	37	1	9416314	9416315	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:9416314_9416315insC	uc010oae.1	+	2	703_704	c.364_365insC	c.(364-366)GCCfs	p.A122fs	SPSB1_uc001apv.2_Frame_Shift_Ins_p.A122fs	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	122	B30.2/SPRY.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		GACGGCAGACGCCCCCCTGCAC	0.658												
PRDM2	7799	broad.mit.edu	37	1	14107246	14107246	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:14107246delC	uc001avi.2	+	8	3812	c.2956delC	c.(2956-2958)CCCfs	p.P986fs	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Frame_Shift_Del_p.P986fs|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Frame_Shift_Del_p.P785fs|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	986	Pro-rich.|SH3-binding (Potential).					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		TGCCACTCCGCCCCCTCCCCT	0.617												
PRDM2	7799	broad.mit.edu	37	1	14107892	14107893	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:14107892_14107893insT	uc001avi.2	+	8	4458_4459	c.3602_3603insT	c.(3601-3603)GCTfs	p.A1201fs	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Frame_Shift_Ins_p.A1201fs|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Frame_Shift_Ins_p.A1000fs|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1201	C2H2-type 6.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		AAAGAATTTGCTTTTTTGTGCA	0.431												
MAP3K6	9064	broad.mit.edu	37	1	27687696	27687696	+	Frame_Shift_Del	DEL	G	G	-	rs139401154		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:27687696delG	uc001bny.1	-	13	2033	c.1784delC	c.(1783-1785)CCGfs	p.P595fs	MAP3K6_uc009vsw.1_Frame_Shift_Del_p.P587fs|MAP3K6_uc001bnz.1_Frame_Shift_Del_p.P118fs	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	595					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GTCCTGAGCCGGGGGGAGTGC	0.662												
TIE1	7075	broad.mit.edu	37	1	43770692	43770692	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:43770692delC	uc001ciu.2	+	2	308	c.229delC	c.(229-231)CCCfs	p.P77fs	TIE1_uc010okd.1_Frame_Shift_Del_p.P77fs|TIE1_uc010oke.1_Frame_Shift_Del_p.P32fs|TIE1_uc009vwq.2_Frame_Shift_Del_p.P77fs|TIE1_uc010okf.1_5'UTR|TIE1_uc010okg.1_5'Flank|TIE1_uc010oka.1_Frame_Shift_Del_p.P77fs|TIE1_uc010okb.1_Frame_Shift_Del_p.P77fs|TIE1_uc010okc.1_Frame_Shift_Del_p.P77fs	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	77	Extracellular (Potential).|Ig-like C2-type 1.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCCCGGGCCACCCCTGCGCCT	0.746												
WDR63	126820	broad.mit.edu	37	1	85598680	85598680	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:85598680delA	uc001dkt.2	+	23	2866	c.2675delA	c.(2674-2676)TAAfs	p.*892fs	WDR63_uc009wcl.2_Frame_Shift_Del_p.*853fs	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	892										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		GAGGTGATGTAAAAAAGCTTC	0.388												
RWDD3	25950	broad.mit.edu	37	1	95709927	95709928	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:95709927_95709928delTG	uc009wdu.2	+	2	322_323	c.246_247delTG	c.(244-249)ACTGTGfs	p.T82fs	RWDD3_uc001drd.3_3'UTR|RWDD3_uc010oty.1_Frame_Shift_Del_p.T67fs|RWDD3_uc009wdt.2_Frame_Shift_Del_p.T82fs|RWDD3_uc001drf.3_Frame_Shift_Del_p.T82fs|RWDD3_uc001drh.3_Frame_Shift_Del_p.T67fs|RWDD3_uc009wdv.2_Intron|RWDD3_uc001drg.3_RNA|RWDD3_uc001dri.3_Frame_Shift_Del_p.T82fs	NM_015485	NP_056300	Q9Y3V2	RWDD3_HUMAN	RWD domain containing 3 isoform a	82_83	RWD.					cytoplasm|nucleus	protein binding			ovary(1)	1		all_epithelial(167;5.99e-05)|all_lung(203;0.00168)|Lung NSC(277;0.00769)		all cancers(265;0.112)|Epithelial(280;0.229)		AGTGTGTGACTGTGAAAGAGAA	0.460												
SLC27A3	11000	broad.mit.edu	37	1	153749150	153749150	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:153749150delC	uc001fcz.2	+	2	1030	c.965delC	c.(964-966)TCCfs	p.S322fs	SLC27A3_uc009won.2_RNA	NM_024330	NP_077306	Q5K4L6	S27A3_HUMAN	solute carrier family 27 member 3	322					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			ovary(1)	1	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TACCTCTCTTCCCCCCAGAGC	0.597												
ILDR2	387597	broad.mit.edu	37	1	166890564	166890564	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:166890564delC	uc001gdx.1	-	9	1320	c.1264delG	c.(1264-1266)GTGfs	p.V422fs		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	422	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						ACGGCCGGCACCCCCGTGGCG	0.721												
LARP4B	23185	broad.mit.edu	37	10	890939	890939	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:890939delT	uc001ifs.1	-	5	528	c.487delA	c.(487-489)ACAfs	p.T163fs		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	163	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						AATTCCAATGTTTTTTTAAGT	0.353												
MASTL	84930	broad.mit.edu	37	10	27459254	27459254	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:27459254delA	uc001itm.2	+	8	2005	c.1366delA	c.(1366-1368)AAAfs	p.K456fs	MASTL_uc001itl.2_Frame_Shift_Del_p.K456fs|MASTL_uc009xkw.1_Frame_Shift_Del_p.K456fs|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	456	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CAGTCCTTGTAAAAAAATTAT	0.338												
SIRT1	23411	broad.mit.edu	37	10	69676036	69676036	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:69676036delT	uc001jnd.2	+	9	1983	c.1930delT	c.(1930-1932)TTTfs	p.F644fs	SIRT1_uc010qis.1_Frame_Shift_Del_p.F349fs|SIRT1_uc009xpp.2_Frame_Shift_Del_p.F452fs|SIRT1_uc001jne.2_Frame_Shift_Del_p.F341fs	NM_012238	NP_036370	Q96EB6	SIRT1_HUMAN	sirtuin 1 isoform a	644					apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding				0						TCAGTATCTGTTTTTGCCACC	0.393												
MYPN	84665	broad.mit.edu	37	10	69881820	69881822	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:69881820_69881822delTCT	uc001jnm.3	+	3	810_812	c.625_627delTCT	c.(625-627)TCTdel	p.S210del	MYPN_uc001jnl.1_In_Frame_Del_p.S210del|MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_In_Frame_Del_p.S210del|MYPN_uc001jnp.1_In_Frame_Del_p.S210del|MYPN_uc009xps.2_In_Frame_Del_p.S210del|MYPN_uc009xpt.2_In_Frame_Del_p.S210del|MYPN_uc010qit.1_5'UTR|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	210	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						ACGAGAAAGATCTTCTGTTCCCA	0.488												
KIF20B	9585	broad.mit.edu	37	10	91483767	91483767	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:91483767delA	uc001kgs.1	+	14	1841	c.1769delA	c.(1768-1770)GAAfs	p.E590fs	KIF20B_uc001kgr.1_Frame_Shift_Del_p.E590fs|KIF20B_uc001kgt.1_5'UTR	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	590	Potential.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						CTGATAAATGAAAAAAAGGAA	0.284												
LDB1	8861	broad.mit.edu	37	10	103871226	103871226	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:103871226delG	uc009xwz.2	-	2	436	c.93delC	c.(91-93)CCCfs	p.P31fs	LDB1_uc001kuk.3_5'UTR|LDB1_uc001kul.3_5'UTR	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	31					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		CGGGATGGAAGGGGGGAAAGG	0.537												
PRDX3	10935	broad.mit.edu	37	10	120936633	120936634	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:120936633_120936634insC	uc001lec.2	-	2	111_112	c.68_69insG	c.(67-69)GGCfs	p.G23fs		NM_006793	NP_006784	P30048	PRDX3_HUMAN	peroxiredoxin 3 isoform a precursor	23					cell redox homeostasis|hydrogen peroxide catabolic process|mitochondrion organization|myeloid cell differentiation|negative regulation of kinase activity|positive regulation of cell proliferation|positive regulation of NF-kappaB transcription factor activity|regulation of mitochondrial membrane potential|response to lipopolysaccharide	early endosome|mitochondrion	alkyl hydroperoxide reductase activity|caspase inhibitor activity|peroxidase activity|peroxiredoxin activity|protein C-terminus binding|protein kinase binding				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0245)		TGGCAGAAATGCCCCAAGGAAT	0.475												
OR52H1	390067	broad.mit.edu	37	11	5565960	5565960	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:5565960delA	uc010qzh.1	-	1	794	c.794delT	c.(793-795)TTCfs	p.F265fs	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	265	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGATGGAGAAAAAGGCAGG	0.507												
DNHD1	144132	broad.mit.edu	37	11	6585775	6585775	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:6585775delC	uc001mdw.3	+	32	11061	c.10497delC	c.(10495-10497)AACfs	p.N3499fs	DNHD1_uc001mea.3_5'UTR|DNHD1_uc001meb.2_5'UTR|DNHD1_uc001mec.2_5'Flank|DNHD1_uc010rao.1_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3499					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CACCAAAGAACCCCCTGCTGG	0.537												
ALX4	60529	broad.mit.edu	37	11	44286624	44286624	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:44286624delG	uc001myb.2	-	4	1120	c.1016delC	c.(1015-1017)CCTfs	p.P339fs		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	339					hair follicle development						0						CCCAGAGCCAGGGGGGTGGGC	0.692												
OR4A16	81327	broad.mit.edu	37	11	55111418	55111419	+	Frame_Shift_Ins	INS	-	-	T	rs141537673		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:55111418_55111419insT	uc010rie.1	+	1	742_743	c.742_743insT	c.(742-744)GTTfs	p.V248fs		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	248	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						GGTTGCCCTCGTTTTTGTTCCC	0.396												
FAM111A	63901	broad.mit.edu	37	11	58920101	58920101	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:58920101delA	uc010rkp.1	+	5	1187	c.960delA	c.(958-960)GTAfs	p.V320fs	FAM111A_uc010rkq.1_Frame_Shift_Del_p.V320fs|FAM111A_uc010rkr.1_Frame_Shift_Del_p.V320fs|FAM111A_uc001nno.2_Frame_Shift_Del_p.V320fs|FAM111A_uc001nnp.2_Frame_Shift_Del_p.V320fs|FAM111A_uc001nnq.2_Frame_Shift_Del_p.V320fs	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	320					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				AAATGAAAGTAAAAAATGGGG	0.328												
INCENP	3619	broad.mit.edu	37	11	61912525	61912527	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:61912525_61912527delGGA	uc001nsw.1	+	12	1879_1881	c.1677_1679delGGA	c.(1675-1680)GTGGAG>GTG	p.E561del	INCENP_uc009ynw.1_In_Frame_Del_p.E561del|INCENP_uc001nsx.1_In_Frame_Del_p.E557del|INCENP_uc001nsy.1_5'UTR	NM_001040694	NP_001035784	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	561	Potential.				chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			lung(1)	1						GGCAGAAGGTGGAGGAGGACAAG	0.675												
PLCZ1	89869	broad.mit.edu	37	12	18889158	18889158	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:18889158delA	uc010sid.1	-	3	323	c.132delT	c.(130-132)TTTfs	p.F44fs	PLCZ1_uc001rdv.3_5'UTR|PLCZ1_uc001rdw.3_5'UTR|CAPZA3_uc001rdy.2_5'Flank	NM_033123	NP_149114	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	44	EF-hand.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					ATCTTACCTTAAAAATCTGTT	0.353												
SLC4A8	9498	broad.mit.edu	37	12	51844775	51844775	+	Frame_Shift_Del	DEL	G	G	-	rs139949142		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:51844775delG	uc001rys.1	+	3	424	c.246delG	c.(244-246)CAGfs	p.Q82fs	SLC4A8_uc010sni.1_Frame_Shift_Del_p.Q29fs|SLC4A8_uc001rym.2_Frame_Shift_Del_p.Q29fs|SLC4A8_uc001ryn.2_Frame_Shift_Del_p.Q29fs|SLC4A8_uc001ryo.2_Frame_Shift_Del_p.Q29fs|SLC4A8_uc001ryp.1_Frame_Shift_Del_p.Q29fs|SLC4A8_uc010snj.1_Frame_Shift_Del_p.Q109fs|SLC4A8_uc001ryq.3_Frame_Shift_Del_p.Q82fs|SLC4A8_uc001ryr.2_Frame_Shift_Del_p.Q82fs|SLC4A8_uc010snk.1_Frame_Shift_Del_p.Q29fs	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	82	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		GAGCCAGCCAGGGGGAGGAAG	0.672												
CDK2	1017	broad.mit.edu	37	12	56362650	56362650	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:56362650delT	uc001sit.3	+	4	641	c.404delT	c.(403-405)ATTfs	p.I135fs	CDK2_uc001siu.3_Frame_Shift_Del_p.I135fs|CDK2_uc010spy.1_Frame_Shift_Del_p.I109fs	NM_001798	NP_001789	P24941	CDK2_HUMAN	cyclin-dependent kinase 2 isoform 1	135	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|blood coagulation|cell division|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA replication|G1/S transition of mitotic cell cycle|G2 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|histone phosphorylation|M/G1 transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation|Ras protein signal transduction|regulation of DNA replication|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol	ATP binding|cyclin-dependent protein kinase activity|identical protein binding			stomach(1)|central_nervous_system(1)	2			UCEC - Uterine corpus endometrioid carcinoma (6;0.123)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			AATCTGCTTATTAACACAGAG	0.507												
MVK	4598	broad.mit.edu	37	12	110019240	110019240	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:110019240delC	uc001toy.3	+	5	596	c.412delC	c.(412-414)CCCfs	p.P138fs	MVK_uc009zvk.2_Frame_Shift_Del_p.P138fs|MVK_uc010sxr.1_Intron|MVK_uc001toz.3_Intron|MVK_uc001tpc.3_RNA	NM_001114185	NP_001107657	Q03426	KIME_HUMAN	mevalonate kinase	138	ATP (By similarity).				cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity				0						GTCGGAGCTGCCCCCCGGGGC	0.667												
EP400	57634	broad.mit.edu	37	12	132538120	132538121	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:132538120_132538121insG	uc001ujn.2	+	42	7741_7742	c.7706_7707insG	c.(7705-7707)ACGfs	p.T2569fs	EP400_uc001ujl.2_Frame_Shift_Ins_p.T2568fs|EP400_uc001ujm.2_Frame_Shift_Ins_p.T2488fs	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2605	Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GCAATCACGACGGGGGGCAGTG	0.515												
EDNRB	1910	broad.mit.edu	37	13	78475267	78475267	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:78475267delA	uc001vko.2	-	4	1135	c.877delT	c.(877-879)TATfs	p.Y293fs	EDNRB_uc001vkq.1_Frame_Shift_Del_p.Y293fs|uc001vkn.1_Intron|EDNRB_uc010aez.1_Frame_Shift_Del_p.Y293fs|EDNRB_uc001vkp.1_Frame_Shift_Del_p.Y376fs	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	293	Helical; Name=5; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	ATTAGTGTATAAAAAAATGCA	0.343												
DOCK9	23348	broad.mit.edu	37	13	99502312	99502312	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:99502312delA	uc001vnt.2	-	36	4060	c.4005delT	c.(4003-4005)TTTfs	p.F1335fs	DOCK9_uc001vnw.2_Frame_Shift_Del_p.F1334fs|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Frame_Shift_Del_p.F1335fs|DOCK9_uc001vnr.2_5'Flank|DOCK9_uc010tin.1_5'Flank|DOCK9_uc001vns.2_5'Flank|DOCK9_uc010tio.1_Frame_Shift_Del_p.F4fs|DOCK9_uc010tip.1_Frame_Shift_Del_p.F22fs|DOCK9_uc001vnu.1_5'Flank|DOCK9_uc010tiq.1_Frame_Shift_Del_p.F313fs	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1335					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAGATATTGTAAAAAAATCCA	0.318												
G2E3	55632	broad.mit.edu	37	14	31071214	31071214	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:31071214delA	uc001wqk.2	+	10	1041	c.887delA	c.(886-888)CAAfs	p.Q296fs	G2E3_uc010tpe.1_Frame_Shift_Del_p.Q211fs|G2E3_uc010tpf.1_Frame_Shift_Del_p.Q250fs	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	296					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GGAGAGTTCCAAAAAGCCAAA	0.299												
PAPLN	89932	broad.mit.edu	37	14	73718481	73718481	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:73718481delG	uc010ttx.1	+	8	943	c.780delG	c.(778-780)GAGfs	p.E260fs	PAPLN_uc001xnw.3_Frame_Shift_Del_p.E233fs|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Frame_Shift_Del_p.E260fs	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	260						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GGGGTGCTGAGGGGGACCTGG	0.672												
C14orf43	91748	broad.mit.edu	37	14	74205773	74205773	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:74205773delG	uc001xot.2	-	2	1722	c.939delC	c.(937-939)CCCfs	p.P313fs	C14orf43_uc001xou.2_Frame_Shift_Del_p.P313fs|C14orf43_uc010tud.1_Frame_Shift_Del_p.P313fs|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	313	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		TATCTGGGTTGGGGGGGAAGG	0.662												
YLPM1	56252	broad.mit.edu	37	14	75265533	75265533	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:75265533delA	uc001xqj.3	+	5	3657	c.3533delA	c.(3532-3534)GAAfs	p.E1178fs	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	983	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GATGGTGGGGAAAAAATGTAT	0.517												
MEIS2	4212	broad.mit.edu	37	15	37329090	37329090	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:37329090delT	uc001zjr.2	-	8	1862	c.825delA	c.(823-825)AAAfs	p.K275fs	MEIS2_uc001zjl.2_Frame_Shift_Del_p.K262fs|MEIS2_uc010ucj.1_Frame_Shift_Del_p.K262fs|MEIS2_uc001zjm.2_Frame_Shift_Del_p.K187fs|MEIS2_uc001zjn.2_Frame_Shift_Del_p.K129fs|MEIS2_uc001zjo.2_Frame_Shift_Del_p.K275fs|MEIS2_uc001zjp.2_Frame_Shift_Del_p.K275fs|MEIS2_uc001zjs.2_Frame_Shift_Del_p.K275fs|MEIS2_uc001zju.2_Frame_Shift_Del_p.K262fs|MEIS2_uc001zjt.2_Frame_Shift_Del_p.K275fs	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	275					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		TCTTCTGGCGTTTTTTGTCCT	0.398												
DYX1C1	161582	broad.mit.edu	37	15	55759182	55759182	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:55759182delT	uc002adc.2	-	5	951	c.583delA	c.(583-585)ATAfs	p.I195fs	CCPG1_uc002acy.2_5'UTR|DYX1C1_uc010ugh.1_RNA|DYX1C1_uc010ugi.1_Intron|DYX1C1_uc002adb.2_Frame_Shift_Del_p.I195fs|DYX1C1_uc002add.2_Frame_Shift_Del_p.I195fs	NM_130810	NP_570722	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1 isoform a	195					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			skin(1)	1				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		ttatattttattttttttctt	0.154												
TRIP4	9325	broad.mit.edu	37	15	64686305	64686305	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:64686305delA	uc002anm.2	+	2	305	c.262delA	c.(262-264)AAAfs	p.K88fs		NM_016213	NP_057297	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	88					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3						GCAGTGCTTCAAAAAAGATGG	0.318												
IGDCC4	57722	broad.mit.edu	37	15	65678319	65678319	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:65678319delG	uc002aou.1	-	18	3240	c.3030delC	c.(3028-3030)CCCfs	p.P1010fs	IGDCC4_uc002aot.1_Frame_Shift_Del_p.P598fs	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1010	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						CTGGGGGGCTGGGGGGGCCAA	0.662											OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
FSD2	123722	broad.mit.edu	37	15	83434691	83434691	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:83434691delC	uc002bjd.2	-	10	1813	c.1646delG	c.(1645-1647)GGCfs	p.G549fs	FSD2_uc010uol.1_Frame_Shift_Del_p.G504fs|FSD2_uc010uom.1_Frame_Shift_Del_p.G504fs	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	549	Fibronectin type-III 2.|B30.2/SPRY.									central_nervous_system(1)	1						CACGCTGGGGCCCCCCATATT	0.617												
PDE8A	5151	broad.mit.edu	37	15	85634360	85634360	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:85634360delA	uc002blh.2	+	8	989	c.800delA	c.(799-801)GAAfs	p.E267fs	PDE8A_uc002bli.2_Intron|PDE8A_uc010bnc.2_Frame_Shift_Del_p.E20fs|PDE8A_uc010bnd.2_Frame_Shift_Del_p.E20fs|PDE8A_uc002blj.2_Intron|PDE8A_uc002blk.2_Intron	NM_002605	NP_002596	O60658	PDE8A_HUMAN	phosphodiesterase 8A isoform 1	267	PAS.				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			CCTATAAATGAAAAAAAGGCT	0.388												
UNKL	64718	broad.mit.edu	37	16	1417261	1417263	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:1417261_1417263delCTT	uc010brn.1	-	8	1015_1017	c.997_999delAAG	c.(997-999)AAGdel	p.K333del	UNKL_uc002cln.2_In_Frame_Del_p.K125del|UNKL_uc002clo.2_In_Frame_Del_p.K122del|UNKL_uc002clp.2_In_Frame_Del_p.K125del			Q9H9P5	UNKL_HUMAN	SubName: Full=Putative ubiquitin-protein ligase;          EC=6.3.2.19; Flags: Fragment;	623						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				CCACCTCCTCCTTCTTCTGCAGC	0.690												
PKD1	5310	broad.mit.edu	37	16	2166583	2166583	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:2166583delG	uc002cos.1	-	8	1878	c.1669delC	c.(1669-1671)CTGfs	p.L557fs	PKD1_uc002cot.1_Frame_Shift_Del_p.L557fs	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	557	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						AGAGGCGTCAGGGGTCCCTGC	0.716												
ZNF48	197407	broad.mit.edu	37	16	30409310	30409310	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:30409310delC	uc002dya.1	+	2	798	c.739delC	c.(739-741)CCCfs	p.P247fs	ZNF48_uc002dxz.1_Frame_Shift_Del_p.P124fs	NM_152652	NP_689865	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGGGGAGCAGCCCCCCCGACC	0.637												
ZNF689	115509	broad.mit.edu	37	16	30616641	30616641	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:30616641delG	uc002dyx.2	-	3	767	c.447delC	c.(445-447)CCCfs	p.P149fs	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	149	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CAGGGCAGATGGGGCCCCCGG	0.607												
CNOT1	23019	broad.mit.edu	37	16	58555109	58555110	+	In_Frame_Ins	INS	-	-	TAC			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:58555109_58555110insTAC	uc002env.2	-	48	7322_7323	c.7029_7030insGTA	c.(7027-7032)insGTA	p.2343_2344insV	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_In_Frame_Ins_p.2338_2339insV|CNOT1_uc002ent.2_In_Frame_Ins_p.281_282insV|CNOT1_uc010vik.1_In_Frame_Ins_p.1300_1301insV	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2343_2344					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GGGGCACAGTGTACAAATTCAT	0.401												
GFOD2	81577	broad.mit.edu	37	16	67719395	67719395	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:67719395delG	uc002eub.2	-	2	519	c.224delC	c.(223-225)CCTfs	p.P75fs	GFOD2_uc002euc.2_Intron|GFOD2_uc010cen.2_Frame_Shift_Del_p.P75fs	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	75						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		GGTGAGTGGAGGGGGGATGCT	0.582												
TERF2IP	54386	broad.mit.edu	37	16	75690320	75690320	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:75690320delA	uc002fet.1	+	3	1108	c.1011delA	c.(1009-1011)CTAfs	p.L337fs		NM_018975	NP_061848	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting	337					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1						AGGCCTTCCTAAAAAATAGTG	0.443												
TXNDC17	84817	broad.mit.edu	37	17	6544520	6544520	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:6544520delA	uc002gdf.3	+	1	299	c.118delA	c.(118-120)AAAfs	p.K40fs	KIAA0753_uc002gde.3_5'Flank|KIAA0753_uc010vte.1_5'Flank	NM_032731	NP_116120	Q9BRA2	TXD17_HUMAN	thioredoxin-like 5	40					tumor necrosis factor-mediated signaling pathway	cytosol	electron carrier activity|peroxidase activity|protein binding|protein-disulfide reductase activity			ovary(1)	1						CGCCGGGGGGAAAAGCTGGTG	0.632												
MPRIP	23164	broad.mit.edu	37	17	17046886	17046886	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:17046886delC	uc002gqu.1	+	9	1108	c.1052delC	c.(1051-1053)GCCfs	p.A351fs	MPRIP_uc002gqv.1_Frame_Shift_Del_p.A351fs|MPRIP_uc002gqw.1_Intron	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	351	Interaction with F-actin (By similarity).					cytoplasm|cytoskeleton	actin binding				0						ACCAATGAAGCCCCCCCAGCT	0.652												
RAI1	10743	broad.mit.edu	37	17	17696624	17696624	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:17696624delG	uc002grm.2	+	3	831	c.362delG	c.(361-363)TGGfs	p.W121fs	RAI1_uc002grn.1_Frame_Shift_Del_p.W121fs	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	121						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CTTCAGGCTTGGGGGGCCCCA	0.652												
NF1	4763	broad.mit.edu	37	17	29684298	29684298	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:29684298delA	uc002hgg.2	+	54	8214	c.7881delA	c.(7879-7881)GTAfs	p.V2627fs	NF1_uc002hgh.2_Frame_Shift_Del_p.V2606fs|NF1_uc010cso.2_Frame_Shift_Del_p.V815fs|NF1_uc010wbt.1_Frame_Shift_Del_p.V105fs|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2627					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTACACTGGTAAAATATACCA	0.378			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)		
MPP2	4355	broad.mit.edu	37	17	41959741	41959741	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:41959741delG	uc010wip.1	-	6	784	c.727delC	c.(727-729)CGCfs	p.R243fs	MPP2_uc002ien.1_Frame_Shift_Del_p.R215fs|MPP2_uc010wim.1_Frame_Shift_Del_p.R187fs|MPP2_uc002ieo.1_Frame_Shift_Del_p.R198fs|MPP2_uc010win.1_Frame_Shift_Del_p.R59fs|MPP2_uc010wio.1_Frame_Shift_Del_p.R187fs|MPP2_uc010czm.1_Frame_Shift_Del_p.R181fs	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	222	PDZ.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		TGCAGTGCGCGGGGGTCACTG	0.652												
MTMR4	9110	broad.mit.edu	37	17	56590291	56590291	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:56590291delC	uc002iwj.2	-	3	125	c.15delG	c.(13-15)GGGfs	p.G5fs	MTMR4_uc010dcx.1_Frame_Shift_Del_p.G19fs	NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	5						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCTGGGGGGCCCCTCCTCAC	0.562												
POLG2	11232	broad.mit.edu	37	17	62492629	62492630	+	Frame_Shift_Del	DEL	AG	AG	-	rs149446102		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:62492629_62492630delAG	uc002jei.2	-	1	540_541	c.457_458delCT	c.(457-459)CTAfs	p.L153fs	POLG2_uc010deg.1_Frame_Shift_Del_p.L153fs	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	153					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			GATTTCGCGTAGAGTTTCTGCA	0.495												
CHST9	83539	broad.mit.edu	37	18	24524315	24524316	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:24524315_24524316insT	uc002kwd.2	-	4	415_416	c.217_218insA	c.(217-219)ATCfs	p.I73fs	C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Intron|CHST9_uc002kwe.2_Frame_Shift_Ins_p.I73fs	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	73	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					ATGTTCCTGGATTTTTTCTGTA	0.302												
ONECUT2	9480	broad.mit.edu	37	18	55104001	55104001	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:55104001delC	uc002lgo.2	+	1	1085	c.1053delC	c.(1051-1053)ATCfs	p.I351fs		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	351	CUT.				organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		GCTACAGTATCCCCCAGGCGA	0.602												
ATP8B1	5205	broad.mit.edu	37	18	55371796	55371798	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:55371796_55371798delAAG	uc002lgw.2	-	3	382_384	c.382_384delCTT	c.(382-384)CTTdel	p.L128del	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	128	Helical; (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				CCTGTAAGATAAGAAGAGCCAGG	0.315									Byler_disease			
ALPK2	115701	broad.mit.edu	37	18	56246941	56246941	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:56246941delA	uc002lhj.3	-	4	1281	c.1067delT	c.(1066-1068)TTAfs	p.L356fs		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	356							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GCTTTCTAATAAAAAAACATG	0.478											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
APBA3	9546	broad.mit.edu	37	19	3752611	3752611	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:3752611delC	uc002lyp.1	-	8	1467	c.1290delG	c.(1288-1290)GGGfs	p.G430fs	APBA3_uc002lyo.1_Frame_Shift_Del_p.G188fs	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	430	PDZ 1.				intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCAGCAGGCCCCCCGTGCA	0.746												
KDM4B	23030	broad.mit.edu	37	19	5131158	5131158	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:5131158delC	uc002mbq.3	+	12	1613	c.1387delC	c.(1387-1389)CCCfs	p.P463fs	KDM4B_uc010xim.1_Frame_Shift_Del_p.P497fs|KDM4B_uc002mbr.3_Frame_Shift_Del_p.P221fs	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	463	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						CGGCCTGCTGCCCCCACAGCT	0.697												
CCDC97	90324	broad.mit.edu	37	19	41828552	41828554	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:41828552_41828554delGAG	uc002oqg.2	+	5	1086_1088	c.964_966delGAG	c.(964-966)GAGdel	p.E324del	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	324											0						GGCACGGGATGAGGAGGAGAGGT	0.631												
FAM83E	54854	broad.mit.edu	37	19	49107038	49107038	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:49107038delG	uc002pjn.2	-	4	954	c.889delC	c.(889-891)CAGfs	p.Q297fs	SPACA4_uc002pjo.2_5'Flank	NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	297										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GAGGGTTTCTGGGGGGGCGCA	0.721												
LILRA5	353514	broad.mit.edu	37	19	54822823	54822823	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:54822823delG	uc002qfe.2	-	5	693	c.573delC	c.(571-573)CCCfs	p.P191fs	LILRA5_uc002qff.2_Frame_Shift_Del_p.P179fs|LILRA5_uc010yev.1_Frame_Shift_Del_p.P191fs|LILRA5_uc010yew.1_Frame_Shift_Del_p.P179fs|LILRA5_uc002qfh.1_Frame_Shift_Del_p.P179fs|LILRA5_uc002qfg.1_Frame_Shift_Del_p.P191fs	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	191	Extracellular (Potential).|Ig-like C2-type 2.				innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACTGCCCACTGGGGGTCAGCT	0.592												
MERTK	10461	broad.mit.edu	37	2	112704982	112704982	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:112704982delT	uc002thk.1	+	4	717	c.595delT	c.(595-597)TTTfs	p.F199fs	MERTK_uc002thl.1_Frame_Shift_Del_p.F23fs	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	199	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						ACTTCCTCACTTTACTAAGCA	0.493												
FAM128B	80097	broad.mit.edu	37	2	130948157	130948157	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:130948157delG	uc002tqu.2	+	3	588	c.435delG	c.(433-435)AAGfs	p.K145fs		NM_025029	NP_079305	Q6NZ67	MZT2B_HUMAN	hypothetical protein LOC80097	145						centrosome|gamma-tubulin ring complex|spindle	protein binding				0	Colorectal(110;0.1)					GGCTGCCCAAGGGGGGCGGGC	0.657												
LCT	3938	broad.mit.edu	37	2	136594278	136594279	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:136594278_136594279delAT	uc002tuu.1	-	1	472_473	c.461_462delAT	c.(460-462)TATfs	p.Y154fs		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	154	Extracellular (Potential).|4 X approximate repeats.|1.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CGAATGTGGCATAGTCGGCGAA	0.574												
TTN	7273	broad.mit.edu	37	2	179403334	179403334	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:179403334delA	uc010zfg.1	-	303	91742	c.91518delT	c.(91516-91518)TTTfs	p.F30506fs	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Frame_Shift_Del_p.F24201fs|TTN_uc010zfi.1_Frame_Shift_Del_p.F24134fs|TTN_uc010zfj.1_Frame_Shift_Del_p.F24009fs	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31433							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTCTCAGCAAAAACCCTGA	0.418												
TTN	7273	broad.mit.edu	37	2	179535860	179535860	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:179535860delT	uc010zfg.1	-	151	31586	c.31362delA	c.(31360-31362)AAAfs	p.K10454fs	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Frame_Shift_Del_p.K7115fs|TTN_uc010fre.1_Intron|TTN_uc010zfk.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11381							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAGTGGGCGGTTTTTTTGGAG	0.368												
C2orf69	205327	broad.mit.edu	37	2	200790166	200790167	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:200790166_200790167insA	uc010zhb.1	+	2	898_899	c.715_716insA	c.(715-717)GAAfs	p.E239fs		NM_153689	NP_710156	Q8N8R5	CB069_HUMAN	hypothetical protein LOC205327 precursor	239						extracellular region				central_nervous_system(1)	1						GAGGACCTGTGAAAAATCTGAT	0.386												
ERBB4	2066	broad.mit.edu	37	2	213403254	213403254	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:213403254delT	uc002veg.1	-	1	99	c.1delA	c.(1-3)ATGfs	p.M1fs	ERBB4_uc002veh.1_Frame_Shift_Del_p.M1fs|ERBB4_uc010zji.1_Frame_Shift_Del_p.M1fs|ERBB4_uc010zjj.1_Frame_Shift_Del_p.M1fs|ERBB4_uc010fut.1_Frame_Shift_Del_p.M1fs	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GCCGGCTTCATTTTTTGGAAG	0.537										TSP Lung(8;0.080)		
RBCK1	10616	broad.mit.edu	37	20	409650	409652	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:409650_409652delAGA	uc002wdp.3	+	11	2057_2059	c.1364_1366delAGA	c.(1363-1368)CAGAAG>CAG	p.K457del	RBCK1_uc002wdq.3_In_Frame_Del_p.K415del|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_In_Frame_Del_p.K287del	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	457	IBR-type 2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				ATCGTGGTACAGAAGAAGGACGG	0.685												
SLC23A2	9962	broad.mit.edu	37	20	4843454	4843454	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:4843454delC	uc002wlg.1	-	14	1831	c.1456delG	c.(1456-1458)GTGfs	p.V486fs	SLC23A2_uc010zqr.1_Frame_Shift_Del_p.V371fs|SLC23A2_uc002wlh.1_Frame_Shift_Del_p.V486fs	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	486	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GCTCCCAGCACAGGATCCGGA	0.552												
ISM1	140862	broad.mit.edu	37	20	13260483	13260483	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:13260483delG	uc010gce.1	+	3	587	c.581delG	c.(580-582)AGGfs	p.R194fs	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	194						extracellular region					0						AACCCCCCCAGGGGGTGGGAC	0.542												
TP53INP2	58476	broad.mit.edu	37	20	33296578	33296578	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:33296578delC	uc002xau.1	+	3	370	c.35delC	c.(34-36)ACCfs	p.T12fs		NM_021202	NP_067025	Q8IXH6	T53I2_HUMAN	tumor protein p53 inducible nuclear protein 2	12						nucleus					0						TTCTTCAGCACCCCCTCGCCC	0.662												
NTSR1	4923	broad.mit.edu	37	20	61341143	61341143	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:61341143delC	uc002ydf.2	+	1	955	c.584delC	c.(583-585)GCCfs	p.A195fs		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	195	Helical; Name=4; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			ATCTGGCTCGCCTCGGCCCTG	0.667												
CELSR1	9620	broad.mit.edu	37	22	46931227	46931227	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:46931227delC	uc003bhw.1	-	1	1841	c.1841delG	c.(1840-1842)GGCfs	p.G614fs		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	614	Extracellular (Potential).|Cadherin 4.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGCGCTGCCGCCCCCCAGAAA	0.657												
TOP2B	7155	broad.mit.edu	37	3	25670433	25670433	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:25670433delT	uc011awn.1	-	15	1854	c.1811delA	c.(1810-1812)AATfs	p.N604fs	TOP2B_uc003cdj.2_Frame_Shift_Del_p.N599fs	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	604					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						TTCCTGCTTATTTTTGCTTGC	0.279												
KIF9	64147	broad.mit.edu	37	3	47315092	47315092	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:47315092delC	uc010hjp.2	-	5	920	c.316delG	c.(316-318)GCAfs	p.A106fs	KIF9_uc003cqx.2_Frame_Shift_Del_p.A106fs|KIF9_uc003cqy.2_Frame_Shift_Del_p.A106fs|KIF9_uc011bat.1_Intron|KIF9_uc011bau.1_RNA	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2	106	Kinesin-motor.				blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TTCTCAGTTGCCCCCATCATG	0.557												
GRM2	2912	broad.mit.edu	37	3	51746928	51746928	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:51746928delG	uc010hlv.2	+	3	1129	c.890delG	c.(889-891)TGGfs	p.W297fs	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	297	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	AGTGATGGTTGGGGGGCCCTG	0.642												
SLC25A26	115286	broad.mit.edu	37	3	66293635	66293635	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:66293635delT	uc011bfq.1	+	4	927	c.199delT	c.(199-201)TTTfs	p.F67fs	SLC25A26_uc011bfs.1_5'UTR|SLC25A26_uc011bft.1_RNA|SLC25A26_uc011bfr.1_Frame_Shift_Del_p.F67fs|SLC25A26_uc003dmt.2_5'UTR	NM_173471	NP_775742	Q70HW3	SAMC_HUMAN	solute carrier family 25, member 26 isoform a	67	Solcar 1.|Helical; Name=2; (Potential).					integral to membrane|mitochondrial inner membrane|nucleus	S-adenosylmethionine transmembrane transporter activity			pancreas(1)	1		Lung NSC(201;0.00774)		BRCA - Breast invasive adenocarcinoma(55;0.00046)|KIRC - Kidney renal clear cell carcinoma(15;0.0515)|Kidney(15;0.0648)		AGCTGCTGCATTTTTTATCAC	0.328												
PLXNA1	5361	broad.mit.edu	37	3	126735391	126735391	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:126735391delC	uc003ejg.2	+	15	2981	c.2977delC	c.(2977-2979)CCCfs	p.P993fs		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1016	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		GTGCCTGACACCCCCCGGGCA	0.627												
MED12L	116931	broad.mit.edu	37	3	150845633	150845633	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:150845633delG	uc003eyp.2	+	4	456	c.418delG	c.(418-420)GAGfs	p.E140fs	MED12L_uc011bnz.1_Frame_Shift_Del_p.E140fs|MED12L_uc003eym.1_Frame_Shift_Del_p.E140fs|MED12L_uc003eyn.2_Frame_Shift_Del_p.E140fs|MED12L_uc003eyo.2_Frame_Shift_Del_p.E140fs	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	140					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TAGTAAAAAAGAGGATGTTTT	0.343												
SERPINI1	5274	broad.mit.edu	37	3	167507159	167507159	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:167507159delA	uc003ffa.3	+	2	441	c.243delA	c.(241-243)CTAfs	p.L81fs	SERPINI1_uc003ffb.3_Frame_Shift_Del_p.L81fs	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	81					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						ATGACAGCCTAAAAAATGGTA	0.388												
GPR160	26996	broad.mit.edu	37	3	169802469	169802469	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:169802469delA	uc003fgi.2	+	4	1299	c.709delA	c.(709-711)AAAfs	p.K237fs	GPR160_uc010hwq.2_Frame_Shift_Del_p.K237fs	NM_014373	NP_055188	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	237	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TGTGAGATCTAAAAAAATATT	0.328												
HGFAC	3083	broad.mit.edu	37	4	3450973	3450973	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:3450973delG	uc003ghc.2	+	14	1798	c.1795delG	c.(1795-1797)GGGfs	p.G599fs	HGFAC_uc010icw.2_Frame_Shift_Del_p.G606fs	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	599	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GGGGGACTCAGGGGGGCCCCT	0.682												
SLC34A2	10568	broad.mit.edu	37	4	25665878	25665878	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:25665878delT	uc003grr.2	+	4	386	c.305delT	c.(304-306)ATTfs	p.I102fs	SLC34A2_uc003grs.2_Frame_Shift_Del_p.I101fs|SLC34A2_uc010iev.2_Frame_Shift_Del_p.I101fs	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	102	Helical; Name=M1; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GGGAGATTGATTTTACTTCTC	0.483												
KCTD8	386617	broad.mit.edu	37	4	44177044	44177044	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:44177044delT	uc003gwu.2	-	2	1469	c.1185delA	c.(1183-1185)AAAfs	p.K395fs		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	395						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						GTACAGGTGCTTTTTTAGAGG	0.502										HNSCC(17;0.042)		
SDAD1	55153	broad.mit.edu	37	4	76892547	76892547	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:76892547delT	uc003hje.3	-	9	895	c.776delA	c.(775-777)AACfs	p.N259fs	SDAD1_uc003hjf.3_Frame_Shift_Del_p.N162fs|SDAD1_uc011cbr.1_Frame_Shift_Del_p.N222fs	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	259	Potential.				protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTTTTTCTTGTTTTTGGAACT	0.368												
KIAA1712	80817	broad.mit.edu	37	4	175231156	175231158	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:175231156_175231158delTCT	uc003itr.2	+	8	1248_1250	c.834_836delTCT	c.(832-837)AATCTT>AAT	p.L280del	KIAA1712_uc010iro.2_In_Frame_Del_p.L280del|KIAA1712_uc003its.2_RNA	NM_001040157	NP_001035247	Q9C0F1	CEP44_HUMAN	HBV PreS1-transactivated protein 3 isoform a	280						centrosome|midbody|spindle pole					0		Prostate(90;0.00276)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;4.06e-18)|Epithelial(43;1.18e-15)|OV - Ovarian serous cystadenocarcinoma(60;4.65e-09)|GBM - Glioblastoma multiforme(59;0.00098)|STAD - Stomach adenocarcinoma(60;0.0029)|LUSC - Lung squamous cell carcinoma(193;0.0949)		CCTGGACTAATCTTCTTAGTCGT	0.305												
CDH6	1004	broad.mit.edu	37	5	31294199	31294199	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:31294199delA	uc003jhe.1	+	3	685	c.359delA	c.(358-360)GAAfs	p.E120fs	CDH6_uc003jhd.1_Frame_Shift_Del_p.E120fs	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	120	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GACAGGGAAGAAAAACCCGTT	0.448												
CMYA5	202333	broad.mit.edu	37	5	79030050	79030050	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:79030050delA	uc003kgc.2	+	2	5534	c.5462delA	c.(5461-5463)CAAfs	p.Q1821fs		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1821						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CTTGTAGAACAAAAAAAGACA	0.383												
RASA1	5921	broad.mit.edu	37	5	86675571	86675571	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:86675571delA	uc003kiw.2	+	19	2625	c.2507delA	c.(2506-2508)GAAfs	p.E836fs	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Frame_Shift_Del_p.E659fs|RASA1_uc011ctv.1_Frame_Shift_Del_p.E669fs|RASA1_uc011ctw.1_Frame_Shift_Del_p.E670fs|RASA1_uc010jaw.2_Frame_Shift_Del_p.E658fs	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	836	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TCAAAGTTAGAAAAAAATGAA	0.308												
TSSK1B	83942	broad.mit.edu	37	5	112769462	112769462	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:112769462delG	uc003kqm.2	-	1	1267	c.1075delC	c.(1075-1077)CAAfs	p.Q359fs	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	359					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		GGAGGCTGTTGGGGGGGCCCT	0.597												
KCNN2	3781	broad.mit.edu	37	5	113822813	113822813	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:113822813delA	uc003kqo.2	+	6	1778	c.1321delA	c.(1321-1323)AAAfs	p.K441fs	KCNN2_uc003kqp.2_Frame_Shift_Del_p.K93fs|KCNN2_uc010jcg.2_RNA|uc003kqr.1_Intron	NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	441	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		AAAGCTAGTGAAAAAGATAGA	0.323												
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139892956	139892957	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:139892956_139892957insA	uc003lfs.1	+	24	4333_4334	c.4209_4210insA	c.(4207-4212)TTGAAAfs	p.L1403fs	ANKHD1_uc003lfq.1_Frame_Shift_Ins_p.L1422fs|ANKHD1_uc003lfr.2_Frame_Shift_Ins_p.L1403fs|ANKHD1_uc003lft.1_Frame_Shift_Ins_p.L614fs|ANKHD1_uc003lfu.1_Frame_Shift_Ins_p.L883fs|ANKHD1_uc003lfv.1_Frame_Shift_Ins_p.L480fs|ANKHD1-EIF4EBP3_uc011czh.1_Frame_Shift_Ins_p.L142fs|ANKHD1_uc003lfw.2_Frame_Shift_Ins_p.L41fs	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1403_1404						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAACTGTTGAAAAAATGTCA	0.347												
RREB1	6239	broad.mit.edu	37	6	7247181	7247181	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:7247181delC	uc003mxc.2	+	11	4723	c.4333delC	c.(4333-4335)CCCfs	p.P1445fs	RREB1_uc003mxb.2_Frame_Shift_Del_p.P1500fs|RREB1_uc010jnx.2_Intron	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	1445					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GGAGGAGAAGCCCCCCGAGAC	0.746												
JARID2	3720	broad.mit.edu	37	6	15496722	15496722	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:15496722delG	uc003nbj.2	+	7	1510	c.1266delG	c.(1264-1266)GTGfs	p.V422fs	JARID2_uc011diu.1_Frame_Shift_Del_p.V286fs|JARID2_uc011div.1_Frame_Shift_Del_p.V250fs|JARID2_uc011diw.1_Frame_Shift_Del_p.V384fs	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	422					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CTAAGGAGGTGGGGGGGCGGC	0.667												
KIAA0319	9856	broad.mit.edu	37	6	24596507	24596508	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:24596507_24596508insC	uc011djo.1	-	3	631_632	c.394_395insG	c.(394-396)GACfs	p.D132fs	KIAA0319_uc011djp.1_Frame_Shift_Ins_p.D87fs|KIAA0319_uc003neh.1_Frame_Shift_Ins_p.D132fs|KIAA0319_uc011djq.1_Frame_Shift_Ins_p.D123fs|KIAA0319_uc011djr.1_Frame_Shift_Ins_p.D132fs	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	132	Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						CTCAGGTGAGTCCCCCCAGATC	0.550												
MDC1	9656	broad.mit.edu	37	6	30675170	30675172	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:30675170_30675172delCTT	uc003nrg.3	-	9	3513_3515	c.3073_3075delAAG	c.(3073-3075)AAGdel	p.K1025del	MDC1_uc003nrf.3_In_Frame_Del_p.K415del|MDC1_uc011dmp.1_In_Frame_Del_p.K632del	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1025				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CCCTGGAAACCTTCTCAGCAGCT	0.458								Other_conserved_DNA_damage_response_genes				
ARMC2	84071	broad.mit.edu	37	6	109294600	109294600	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:109294600delA	uc003pss.3	+	18	2661	c.2487delA	c.(2485-2487)CTAfs	p.L829fs	ARMC2_uc011eao.1_Frame_Shift_Del_p.L664fs	NM_032131	NP_115507	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	829							binding				0		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		ATCCAGACCTAAAAAACTATC	0.373												
SNX13	23161	broad.mit.edu	37	7	17855827	17855827	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:17855827delT	uc003stw.1	-	19	2177	c.1964delA	c.(1963-1965)AAGfs	p.K655fs	SNX13_uc003stv.2_Frame_Shift_Del_p.K644fs|SNX13_uc010kuc.2_Frame_Shift_Del_p.K441fs|SNX13_uc010kub.2_Frame_Shift_Del_p.K50fs			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	655	PX.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					ATTTAGATCCTTTTTTCTCTT	0.274												
OGDH	4967	broad.mit.edu	37	7	44747227	44747228	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:44747227_44747228insC	uc003tln.2	+	22	2952_2953	c.2843_2844insC	c.(2842-2844)TACfs	p.Y948fs	OGDH_uc011kbx.1_Frame_Shift_Ins_p.Y944fs|OGDH_uc011kby.1_Frame_Shift_Ins_p.Y798fs|OGDH_uc003tlp.2_Frame_Shift_Ins_p.Y959fs|OGDH_uc011kbz.1_Frame_Shift_Ins_p.Y743fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	948					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GTGCAGAAGTACCCCAATGCTG	0.564												
CTTNBP2	83992	broad.mit.edu	37	7	117431604	117431604	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:117431604delT	uc003vjf.2	-	4	1738	c.1646delA	c.(1645-1647)AAGfs	p.K549fs		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	549	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GAGCCCTGGCTTTTTTGGAGG	0.522												
NUP205	23165	broad.mit.edu	37	7	135301910	135301911	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:135301910_135301911insT	uc003vsw.2	+	26	3636_3637	c.3605_3606insT	c.(3604-3606)GATfs	p.D1202fs	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1202					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						TTGCAGTTGGATTTTTTTGATC	0.371												
SSPO	23145	broad.mit.edu	37	7	149501110	149501110	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:149501110delG	uc010lpk.2	+	57	8246	c.8246delG	c.(8245-8247)TGGfs	p.W2749fs		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2749	TSP type-1 6.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCGGCAGCCTGGGGGGGTGCC	0.667												
TLR8	51311	broad.mit.edu	37	X	12939876	12939876	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:12939876delA	uc004cve.2	+	2	2785	c.2717delA	c.(2716-2718)GAAfs	p.E906fs	TLR8_uc004cvd.2_Frame_Shift_Del_p.E924fs	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	906	Cytoplasmic (Potential).|TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TACCACCTTGAAGAGAGCCGA	0.468												
GPR64	10149	broad.mit.edu	37	X	19046358	19046359	+	Splice_Site	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:19046358_19046359insA	uc004cyx.2	-	10	523	c.359_splice	c.e10-1	p.A120_splice	GPR64_uc004cyy.2_Splice_Site_p.A117_splice|GPR64_uc004cyz.2_Splice_Site_p.A106_splice|GPR64_uc004czb.2_Splice_Site_p.A120_splice|GPR64_uc004czc.2_Splice_Site_p.A104_splice|GPR64_uc004czd.2_Splice_Site_p.A96_splice|GPR64_uc004cze.2_Splice_Site_p.A90_splice|GPR64_uc004czf.2_Splice_Site_p.A82_splice|GPR64_uc004cza.2_Splice_Site_p.A98_splice|GPR64_uc004cyw.2_Splice_Site_p.A104_splice|GPR64_uc010nfj.2_Splice_Site_p.A90_splice	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1						neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					TAAAAAATGCTAAAAATAAATT	0.262												
YY2	404281	broad.mit.edu	37	X	21863335	21863335	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:21863335delT	uc010nfq.2	+	3	468	c.271delT	c.(271-273)TTTfs	p.F91fs	MBTPS2_uc004dae.2_Frame_Shift_Del_p.F91fs|MBTPS2_uc004dab.2_Frame_Shift_Del_p.F91fs	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GTTTAGCTCATTTTTTCTCCT	0.284												
TEX13B	56156	broad.mit.edu	37	X	107224932	107224933	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:107224932_107224933delCT	uc004enn.1	-	2	518_519	c.425_426delAG	c.(424-426)GAGfs	p.E142fs		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	142										ovary(1)	1						GCATGTCCCGCTCTCTCTGCAC	0.589												
MAGEA8	4107	broad.mit.edu	37	X	149013887	149013888	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:149013887_149013888insT	uc004fdw.1	+	3	1056_1057	c.841_842insT	c.(841-843)CTTfs	p.L281fs		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	281	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAAGGGCCCTTGCTGAAACC	0.579												
RERE	473	broad.mit.edu	37	1	8674690	8674691	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:8674689_8674690T>TG	uc001ape.3	-	4	1262_1263	c.452_453A>CA	c.(451-453)ccafs	p.P151fs	RERE_uc001apf.3_Frame_Shift_Ins_p.P151fs|RERE_uc001aph.1_Frame_Shift_Ins_p.P151fs	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	Homo sapiens arginine-glutamic acid dipeptide (RE) repeats (RERE), transcript variant 1, mRNA.	151	BAH.				NLS-bearing substrate import into nucleus|multicellular organismal development	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GAGAGCATGCTGGGGGGTCACA	0.520												
SPSB1	80176	broad.mit.edu	37	1	9416315	9416316	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:9416314_9416315G>GC	uc010oae.2	+	1	703_704	c.364_365G>GC	c.(364-366)gccfs	p.A122fs	SPSB1_uc001apv.3_Frame_Shift_Ins_p.A122fs	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	Homo sapiens splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1), mRNA.	122	B30.2/SPRY.				intracellular signal transduction	cytoplasm				breast(1)|endometrium(3)|kidney(2)|lung(5)|prostate(2)	13	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		GACGGCAGACGCCCCCCTGCAC	0.658												
PRDM2	7799	broad.mit.edu	37	1	14107893	14107894	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:14107892_14107893C>CT	uc001avi.3	+	7	4458_4459	c.3602_3603C>CT	c.(3601-3603)gctfs	p.A1201fs	PRDM2_uc001avg.3_Intron|PRDM2_uc001avh.3_Frame_Shift_Ins_p.A1201fs|PRDM2_uc001avk.3_Frame_Shift_Ins_p.A1000fs|PRDM2_uc009voe.3_Intron|PRDM2_uc009vof.3_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	Homo sapiens PR domain containing 2, with ZNF domain (PRDM2), transcript variant 1, mRNA.	1201						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		AAAGAATTTGCTTTTTTGTGCA	0.431												
LYPLA2	11313	broad.mit.edu	37	1	24119502	24119502	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:24119501_24119501AT>A	uc001bht.3	+	2	203	c.82_82AT>A	c.(82-84)attfs	p.I28fs		NM_007260	NP_009191	O95372	LYPA2_HUMAN	Homo sapiens lysophospholipase II (LYPLA2), mRNA.	28					fatty acid metabolic process	cytoplasm	hydrolase activity			endometrium(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		TTTCCAGGTTATTTTTTTACA	0.582												
ARID1A	8289	broad.mit.edu	37	1	27105931	27105931	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:27105930_27105930TG>T	uc001bmv.1	+	19	5914	c.5541_5541TG>T	c.(5539-5541)ggtfs	p.G1847fs	ARID1A_uc001bmu.1_Frame_Shift_Del_p.G1630fs|ARID1A_uc001bmx.1_Frame_Shift_Del_p.G693fs|ARID1A_uc009vsm.1_Frame_Shift_Del_p.G175fs|ARID1A_uc009vsn.1_Frame_Shift_Del_p.G89fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 1, mRNA.	1847					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	SWI/SNF complex|nBAF complex|npBAF complex	DNA binding|protein binding	p.G1848fs*6(3)|p.G1847fs*36(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGCGGATTGGTGGGGGGGACA	0.582			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""							
FGGY	55277	broad.mit.edu	37	1	59812017	59812017	+	Frame_Shift_Del	DEL	G	G	-	rs145440779	by1000genomes	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:59812016_59812016CG>C	uc009wac.3	+	3	623	c.411_411CG>C	c.(409-411)gtcfs	p.V137fs	FGGY_uc001czg.2_Frame_Shift_Del_p.V25fs|FGGY_uc001czh.2_Non-coding_Transcript|FGGY_uc001czi.4_Frame_Shift_Del_p.V137fs|FGGY_uc001czl.4_Intron	NM_001113411	NP_001106882	Q96C11	FGGY_HUMAN	Homo sapiens FGGY carbohydrate kinase domain containing (FGGY), transcript variant 1, mRNA.	137					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					TCCAGTACGTCGGGGGGGTGA	0.502												
PLEKHO1	51177	broad.mit.edu	37	1	150131249	150131249	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:150131248_150131248AC>A	uc001ett.3	+	5	1038	c.760_760AC>A	c.(760-762)accfs	p.T254fs	PLEKHO1_uc001ets.3_Frame_Shift_Del_p.T71fs|PLEKHO1_uc001etu.3_Frame_Shift_Del_p.T82fs|PLEKHO1_uc021oyc.1_Frame_Shift_Del_p.T71fs	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	Homo sapiens pleckstrin homology domain containing, family O member 1 (PLEKHO1), mRNA.	254	Interaction with ATM, CKIP, IFP35 and NMI.					cytoplasm|nucleus|plasma membrane				breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	22	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGCCACCTACACCCCCCAGGC	0.647												
SLC39A1	27173	broad.mit.edu	37	1	153934781	153934782	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:153934780_153934781G>GC	uc001fdl.3	-	3	699_700	c.233_234C>GC	c.(232-234)ggcfs	p.G78fs	SLC39A1_uc001fdi.3_Frame_Shift_Ins_p.G78fs|SLC39A1_uc001fdj.3_Frame_Shift_Ins_p.G78fs|SLC39A1_uc001fdk.3_Frame_Shift_Ins_p.G78fs|SLC39A1_uc010pee.2_Intron	NM_014437	NP_055252	Q9NY26	S39A1_HUMAN	Homo sapiens solute carrier family 39 (zinc transporter), member 1 (SLC39A1), mRNA.	78						endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	zinc ion transmembrane transporter activity			kidney(2)|large_intestine(2)|lung(7)|urinary_tract(1)	12	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)	Colorectal(1306;0.019)		CCAAAAAGACGCCCCCCGCGAA	0.614												
CREB3L4	148327	broad.mit.edu	37	1	153941173	153941174	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:153941172_153941173CTG>C	uc001fdm.1	+	1	439_440	c.171_172CTG>C	c.(169-174)ggctgtfs	p.G57fs	SLC39A1_uc001fdl.3_5'Flank|CREB3L4_uc001fdn.3_Frame_Shift_Del_p.G57fs|CREB3L4_uc010pef.1_5'UTR|CREB3L4_uc001fdo.3_Intron|CREB3L4_uc010peg.1_Frame_Shift_Del_p.G57fs|CREB3L4_uc001fdr.2_Frame_Shift_Del_p.G57fs|CREB3L4_uc001fdq.2_Intron	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	Homo sapiens cAMP responsive element binding protein 3-like 4 (CREB3L4), transcript variant 1, mRNA.	57					response to unfolded protein	Golgi membrane|endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(3)	13	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGGACCGTGGCTGTGTGAGTGT	0.599												
USP21	27005	broad.mit.edu	37	1	161134660	161134660	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:161134659_161134659CA>C	uc010pkc.2	+	11	1796	c.1419_1419CA>C	c.(1417-1419)atcfs	p.I473fs	USP21_uc010pkd.2_Frame_Shift_Del_p.I473fs|USP21_uc021pbv.1_Non-coding_Transcript|PPOX_uc001fyj.2_5'Flank|PPOX_uc001fyg.2_5'Flank|PPOX_uc010pkg.1_5'Flank|PPOX_uc001fyi.2_5'Flank|PPOX_uc010pkh.1_5'Flank	NM_001014443	NP_036607	Q9UK80	UBP21_HUMAN	Homo sapiens ubiquitin specific peptidase 21 (USP21), transcript variant 3, mRNA.	473					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	NEDD8-specific protease activity|metal ion binding|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GAGGCTCCATCAAAAAAAGTT	0.517												
ADCY10	55811	broad.mit.edu	37	1	167863166	167863167	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:167863165_167863166C>CAA	uc001ger.3	-	7	1051_1052	c.753_754G>TTG	c.(751-756)cttgcafs	p.L251fs	ADCY10_uc010plj.2_Frame_Shift_Ins_p.L98fs|ADCY10_uc009wvk.3_Frame_Shift_Ins_p.L159fs|ADCY10_uc009wvl.3_Frame_Shift_Ins_p.L250fs|ADCY10_uc009wvm.2_Non-coding_Transcript	NM_018417	NP_001161221	Q96PN6	ADCYA_HUMAN	Homo sapiens adenylate cyclase 10 (soluble) (ADCY10), transcript variant 1, mRNA.	251					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	ATP binding|adenylate cyclase activity|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AGCGTGCATGCAAGCCTCAGGA	0.490												
ADCY10	55811	broad.mit.edu	37	1	167870995	167870995	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:167870994_167870994GT>G	uc001ger.3	-	4	640	c.342_342AC>C	c.(340-342)aacfs	p.N114fs	ADCY10_uc010plj.2_Intron|ADCY10_uc009wvk.3_Frame_Shift_Del_p.N22fs|ADCY10_uc009wvl.3_Frame_Shift_Del_p.N113fs|ADCY10_uc009wvm.2_Intron	NM_018417	NP_001161221	Q96PN6	ADCYA_HUMAN	Homo sapiens adenylate cyclase 10 (soluble) (ADCY10), transcript variant 1, mRNA.	114	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	ATP binding|adenylate cyclase activity|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						CTGTGATAATGTTTTTCAGCT	0.507												
FAM5C	339479	broad.mit.edu	37	1	190067583	190067583	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:190067582_190067582CA>C	uc001gse.1	-	7	2099	c.1867_1867TG>G	c.(1867-1869)gagfs	p.E623fs	FAM5C_uc010pot.1_Frame_Shift_Del_p.E521fs	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	Homo sapiens family with sequence similarity 5, member C (FAM5C), mRNA.	623						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					TGTACTGTCTCAAAAAATGTC	0.448												
GOLT1A	127845	broad.mit.edu	37	1	204170836	204170836	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:204170835_204170835AC>A	uc001has.1	-	2	408	c.222_222GT>T	c.(220-222)ggtfs	p.G74fs	GOLT1A_uc001hat.1_Frame_Shift_Del_p.G74fs	NM_198447	NP_940849	Q6ZVE7	GOT1A_HUMAN	Homo sapiens golgi transport 1A (GOLT1A), mRNA.	74					protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane				kidney(1)|lung(2)|urinary_tract(1)	4	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			CGATAACCACACCCCCCAGGA	0.542												
SRGAP2	23380	broad.mit.edu	37	1	206516357	206516357	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:206516356_206516356TA>T	uc001hdy.3	+	0	157	c.156_156TA>T	c.(154-156)tttfs	p.F52fs	SRGAP2_uc009xbt.3_5'UTR|SRGAP2_uc010prt.1_5'UTR|SRGAP2_uc001hdx.3_Frame_Shift_Del_p.F52fs|SRGAP2_uc010pru.2_Frame_Shift_Del_p.F52fs	NM_015326	NP_056141	O75044	FNBP2_HUMAN	Homo sapiens SLIT-ROBO Rho GTPase activating protein 2 (SRGAP2), transcript variant 1, mRNA.	139	FCH.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					GAAGACTCTTTAAAAAGGTAC	0.408												
DYRK3	8444	broad.mit.edu	37	1	206820772	206820772	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:206820771_206820771CT>C	uc001hej.3	+	2	396	c.228_228CT>C	c.(226-228)cacfs	p.H76fs	DYRK3_uc001hek.3_Intron|DYRK3_uc001hei.3_Frame_Shift_Del_p.H56fs	NM_003582	NP_003573	O43781	DYRK3_HUMAN	Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (DYRK3), transcript variant 1, mRNA.	76					erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			ATACTCAGCACTTTTTGGATG	0.373												
KIAA1383	54627	broad.mit.edu	37	1	232943122	232943123	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:232943121_232943122G>GA	uc001hvh.2	+	0	2484_2485	c.2352_2353G>GA	c.(2350-2355)atgaaafs	p.M784fs		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	Homo sapiens KIAA1383 (KIAA1383), mRNA.	642	Ser-rich.									breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)	20		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				ATGTGGAAATGAAAATCCAAAG	0.361												
EXO1	9156	broad.mit.edu	37	1	242045292	242045292	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr1:242045291_242045291CA>C	uc021plj.1	+	11	2497	c.2183_2183CA>C	c.(2182-2184)tcafs	p.S728fs	EXO1_uc001hzh.3_Frame_Shift_Del_p.S728fs|EXO1_uc009xgq.3_Frame_Shift_Del_p.S727fs|EXO1_uc021plk.1_Frame_Shift_Del_p.S728fs	NM_006027	NP_569082	Q9UQ84	EXO1_HUMAN	Homo sapiens exonuclease 1 (EXO1), transcript variant 1, mRNA.	728	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TCTCATTTCTCAAAAAAAGAC	0.318								Editing and processing nucleases				
SULT6B1	391365	broad.mit.edu	37	2	37395141	37395142	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:37395140_37395141CTT>C	uc002rpu.3	-	6	756_757	c.735_736AAG>G	c.(733-738)aaagagfs	p.K245fs	SULT6B1_uc010yni.2_Non-coding_Transcript	NM_001032377	NP_001027549	Q6IMI4	ST6B1_HUMAN	Homo sapiens sulfotransferase family, cytosolic, 6B, member 1 (SULT6B1), mRNA.	283						cytoplasm	sulfotransferase activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				GCTAAGCACTCTTTGAATTTTT	0.391												
LOC728819	728819	broad.mit.edu	37	2	43903432	43903432	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:43903431_43903431TA>T	uc010fav.1	-	0	31	c.31_31TA>A	c.(31-33)aagfs	p.K11fs	PLEKHH2_uc002rte.3_Intron|PLEKHH2_uc002rtf.3_Intron|PLEKHH2_uc010yny.2_Intron	NM_001101330	NP_001094800			Homo sapiens hCG1645220 (LOC728819), mRNA.														all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AACATACCCTTAAAAAATGAT	0.512												
CCDC104	112942	broad.mit.edu	37	2	55756040	55756042	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:55756039_55756041CAGA>C	uc002ryx.2	+	4	581_583	c.383_385CAGA>C	c.(382-387)gcagaa>gCaa	p.E129del	CCDC104_uc002ryy.2_In_Frame_Del_p.E104del	NM_080667	NP_542398	Q96G28	CC104_HUMAN	Homo sapiens coiled-coil domain containing 104 (CCDC104), mRNA.	104										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(2)|lung(1)|ovary(2)	14			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTGTTGGCAGCAGAAGATTTTAC	0.355												
C2orf42	54980	broad.mit.edu	37	2	70406777	70406777	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:70406776_70406776TA>T	uc002sgh.3	-	4	1152	c.824_splice	c.e4-1	p.G275_splice		NM_017880	NP_060350	Q9NWW7	CB042_HUMAN	Homo sapiens chromosome 2 open reading frame 42 (C2orf42), mRNA.	275										endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	12						CTTTAAGACCTAAAAAAAAGA	0.353												
UPP2	151531	broad.mit.edu	37	2	158980303	158980303	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:158980302_158980302GA>G	uc002tzo.3	+	7	897	c.877_877GA>G	c.(877-879)gaafs	p.E293fs	UPP2_uc002tzp.3_Frame_Shift_Del_p.E236fs	NM_001135098	NP_775491	O95045	UPP2_HUMAN	Homo sapiens uridine phosphorylase 2 (UPP2), transcript variant 2, mRNA.	236					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						CTTTTCCAGAGAAAAAAAGTT	0.473												
C2orf69	205327	broad.mit.edu	37	2	200790167	200790168	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:200790166_200790167G>GA	uc010zhb.2	+	1	898_899	c.715_716G>GA	c.(715-717)gaafs	p.E239fs		NM_153689	NP_710156	Q8N8R5	CB069_HUMAN	Homo sapiens chromosome 2 open reading frame 69 (C2orf69), mRNA.	239						extracellular region				central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)|stomach(1)|urinary_tract(1)	11						GAGGACCTGTGAAAAATCTGAT	0.386												
CASP8	841	broad.mit.edu	37	2	202151290	202151290	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:202151289_202151289GA>G	uc002uxr.1	+	9	1621	c.1412_1412GA>G	c.(1411-1413)agafs	p.R471fs	CASP8_uc002uxq.1_Frame_Shift_Del_p.R456fs|CASP8_uc002uxp.1_Frame_Shift_Del_p.R488fs|CASP8_uc002uxu.1_Non-coding_Transcript|CASP8_uc002uxt.1_Frame_Shift_Del_p.R530fs|CASP8_uc002uxw.1_Frame_Shift_Del_p.R456fs|CASP8_uc010ftf.2_Frame_Shift_Del_p.R387fs	NM_033355	NP_203519	Q14790	CASP8_HUMAN	Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant B, mRNA.	471					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						TTCACACTAAGAAAAAAACTT	0.398										HNSCC(4;0.00038)		
CRYGD	1421	broad.mit.edu	37	2	209025577	209025578	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:209025576_209025577A>AC	uc002vcq.4	-	2	493_494	c.476_477T>GT	c.(475-477)ggtfs	p.G159fs	CRYGD_uc021vvu.1_Intron	NM_014617	NP_055432	P07320	CRGD_HUMAN	Homo sapiens crystallin, gamma A (CRYGA), mRNA.	159	Beta/gamma crystallin 'Greek key' 4.				cellular response to reactive oxygen species|visual perception	soluble fraction	protein binding|structural constituent of eye lens			breast(1)|endometrium(1)|lung(3)	5				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		TGGCATCTGCACCCCCCCAGTC	0.530												
ERBB4	2066	broad.mit.edu	37	2	212288881	212288882	+	Splice_Site	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr2:212288880_212288881A>AT	uc002veg.1	-	23	2964	c.2866_splice	c.e23+1	p.C956_splice	ERBB4_uc002veh.1_Splice_Site_p.C956_splice|ERBB4_uc010zji.1_Splice_Site_p.C946_splice|ERBB4_uc010zjj.1_Splice_Site_p.C946_splice	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	Homo sapiens v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (ERBB4), transcript variant JM-a/CVT-1, mRNA.	956	Protein kinase.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GCAGTCTTACATTTGACCATGA	0.366										TSP Lung(8;0.080)		
C3orf20	84077	broad.mit.edu	37	3	14802989	14802990	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:14802988_14802989C>CG	uc003byy.3	+	14	2813_2814	c.2361_2362C>CG	c.(2359-2364)gccgggfs	p.A787fs	C3orf20_uc003byz.3_Frame_Shift_Ins_p.A665fs|C3orf20_uc003bza.3_Frame_Shift_Ins_p.A665fs|C3orf20_uc003bzb.1_Frame_Shift_Ins_p.A288fs|C3orf20_uc011avj.2_Frame_Shift_Ins_p.A114fs	NM_032137	NP_001171887	Q8ND61	CC020_HUMAN	Homo sapiens chromosome 3 open reading frame 20 (C3orf20), transcript variant 1, mRNA.	787						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						AGATGTTTGCCGGGGGGAAGCT	0.470												
SCN11A	11280	broad.mit.edu	37	3	38949441	38949442	+	Splice_Site	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:38949440_38949441C>CT	uc021wvy.1	-	10	1672	c.1473_splice	c.e10+1	p.K491_splice		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	Homo sapiens sodium channel, voltage-gated, type XI, alpha subunit (SCN11A), mRNA.	491					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAAGACTTACCTTTTTTTGGCA	0.386												
SCN11A	11280	broad.mit.edu	37	3	38962726	38962726	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:38962725_38962725GC>G	uc021wvy.1	-	5	933	c.734_734GC>C	c.(733-735)gccfs	p.A245fs		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	Homo sapiens sodium channel, voltage-gated, type XI, alpha subunit (SCN11A), mRNA.	245					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.A245A(1)		NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GCGTAGCAAGGCCCCCACGAT	0.537												
KIF15	56992	broad.mit.edu	37	3	44879832	44879832	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:44879831_44879831CA>C	uc003cnx.4	+	26	3385	c.3236_3236CA>C	c.(3235-3237)tcafs	p.S1079fs	KIF15_uc010hiq.3_Frame_Shift_Del_p.S982fs|KIF15_uc010hir.3_Frame_Shift_Del_p.S127fs	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	Homo sapiens kinesin family member 15 (KIF15), mRNA.	1079					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		ACAGAGGCCTCAAAAAAACAC	0.498												
GLT8D1	55830	broad.mit.edu	37	3	52731828	52731828	+	Frame_Shift_Del	DEL	C	C	-	rs138720022	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:52731827_52731827GC>G	uc003dfi.4	-	3	470	c.239_239GC>C	c.(238-240)gccfs	p.A80fs	GLT8D1_uc003dfk.3_Frame_Shift_Del_p.A80fs|GLT8D1_uc003dfl.3_Frame_Shift_Del_p.A80fs|GLT8D1_uc003dfm.3_Frame_Shift_Del_p.A80fs|GLT8D1_uc003dfn.3_Frame_Shift_Del_p.A80fs	NM_152932	NP_690909	Q68CQ7	GL8D1_HUMAN	Homo sapiens glycosyltransferase 8 domain containing 1 (GLT8D1), transcript variant 1, mRNA.	80						integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)	8				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		AGCTGCAATGGCCCCCCCAAG	0.488												
GBE1	2632	broad.mit.edu	37	3	81548302	81548302	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:81548301_81548301GA>G	uc021xav.1	-	14	2294	c.2012_2012TC>C	c.(2011-2013)tctfs	p.S671fs		NM_000158	NP_000149	Q04446	GLGB_HUMAN	Homo sapiens glucan (1,4-alpha-), branching enzyme 1 (GBE1), mRNA.	671					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		AAAAGCCTCAGAAAAAAAGTC	0.368									Glycogen Storage Disease, type IV			
FILIP1L	11259	broad.mit.edu	37	3	99568273	99568273	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:99568272_99568272GT>G	uc003dtm.3	-	4	2711	c.2248_2248AC>C	c.(2248-2250)ctafs	p.L750fs	MIR548G_uc021xbq.1_Intron|C3orf26_uc003dtk.2_Intron|C3orf26_uc003dtl.3_Intron|FILIP1L_uc003dto.3_Frame_Shift_Del_p.L750fs|FILIP1L_uc010hpf.3_Frame_Shift_Del_p.L326fs|FILIP1L_uc010hpg.3_Frame_Shift_Del_p.L510fs|FILIP1L_uc003dtn.3_Frame_Shift_Del_p.L510fs|FILIP1L_uc021xbr.1_Frame_Shift_Del_p.L510fs|FILIP1L_uc003dtp.1_Frame_Shift_Del_p.L510fs	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	Homo sapiens filamin A interacting protein 1-like (FILIP1L), transcript variant 1, mRNA.	750						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						TGTTGATTTAGTTTTTTTTGC	0.403												
FILIP1L	11259	broad.mit.edu	37	3	99568990	99568990	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:99568989_99568989AT>A	uc003dtm.3	-	4	1994	c.1531_1531AT>T	c.(1531-1533)ttafs	p.L511fs	MIR548G_uc021xbq.1_Intron|C3orf26_uc003dtk.2_Intron|C3orf26_uc003dtl.3_Intron|FILIP1L_uc003dto.3_Frame_Shift_Del_p.L511fs|FILIP1L_uc010hpf.3_Frame_Shift_Del_p.L87fs|FILIP1L_uc010hpg.3_Frame_Shift_Del_p.L271fs|FILIP1L_uc003dtn.3_Frame_Shift_Del_p.L271fs|FILIP1L_uc021xbr.1_Frame_Shift_Del_p.L271fs|FILIP1L_uc003dtp.1_Frame_Shift_Del_p.L271fs	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	Homo sapiens filamin A interacting protein 1-like (FILIP1L), transcript variant 1, mRNA.	511						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						GTTTTCTTTAATTTTTCACTC	0.318												
TOPBP1	11073	broad.mit.edu	37	3	133329880	133329880	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr3:133329879_133329879AT>A	uc003eps.3	-	24	4274	c.4142_4142AT>T	c.(4141-4143)atcfs	p.I1381fs		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), mRNA.	1381					DNA repair|response to ionizing radiation	PML body|microtubule organizing center|spindle pole	DNA binding|protein C-terminus binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	40						TCTTTGCTGGATTTTTTTTCT	0.343								Other conserved DNA damage response genes				
FRAS1	80144	broad.mit.edu	37	4	79362354	79362354	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:79362353_79362353AT>A	uc003hlb.2	+	40	6007	c.5567_5567AT>A	c.(5566-5568)catfs	p.H1856fs	FRAS1_uc003hkw.3_Frame_Shift_Del_p.H1856fs|FRAS1_uc010ijj.2_Frame_Shift_Del_p.H276fs	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Homo sapiens Fraser syndrome 1 (FRAS1), transcript variant 1, mRNA.	1855					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCATTTCACCATTTTTTTGCT	0.418												
CXXC4	80319	broad.mit.edu	37	4	105411999	105412000	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:105411998_105411999CCA>C	uc003hxg.3	-	0	469_470	c.454_455TGG>G	c.(454-456)ggcfs	p.G152fs	AK094561_uc003hxh.1_5'Flank|CXXC4_uc010ilo.3_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	Homo sapiens CXXC finger protein 4 (CXXC4), mRNA.	152					Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		GCTGCAGACGCCACAGTTGATG	0.540												
IL21	59067	broad.mit.edu	37	4	123534051	123534052	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr4:123534050_123534051G>GT	uc003ies.2	-	3	438_439	c.393_394C>AC	c.(391-396)aaaccafs	p.K131fs	IL21_uc010int.3_Frame_Shift_Ins_p.K131fs	NM_021803	NP_068575	Q9HBE4	IL21_HUMAN	Homo sapiens interleukin 21 (IL21), transcript variant 1, mRNA.	124					cell maturation|immune response|positive regulation of T cell proliferation|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(3)	8						TCTTTGGGTGGTTTTTTCTCAT	0.287												
FYB	2533	broad.mit.edu	37	5	39124357	39124358	+	Splice_Site	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:39124356_39124357C>CA	uc003jls.3	-	11	2000	c.1933_splice	c.e11+1	p.D645_splice	FYB_uc003jlt.3_Splice_Site_p.D691_splice|FYB_uc003jlu.3_Splice_Site_p.D645_splice|FYB_uc011cpl.2_Splice_Site_p.D701_splice	NM_199335	NP_955367	O15117	FYB_HUMAN	Homo sapiens FYN binding protein (FYB), transcript variant 2, mRNA.	645					NLS-bearing substrate import into nucleus|T cell receptor signaling pathway|cell junction assembly|immune response|intracellular protein kinase cascade|protein phosphorylation	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			ATTACTTACCCAATTGTTTAGG	0.351												
C6	729	broad.mit.edu	37	5	41181535	41181535	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:41181534_41181534TA>T	uc003jmk.2	-	6	1064	c.854_854TA>A	c.(853-855)tatfs	p.Y285fs	C6_uc003jml.1_Frame_Shift_Del_p.Y285fs	NM_000065	NP_001108603	P13671	CO6_HUMAN	Homo sapiens complement component 6 (C6), transcript variant 1, mRNA.	285	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CTTTGAGGAATAAAAAATTGG	0.368												
TNPO1	3842	broad.mit.edu	37	5	72173171	72173174	+	Frame_Shift_Del	DEL	TAAG	TAAG	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:72173170_72173173CTAAG>C	uc003kck.4	+	8	1064_1067	c.917_920CTAAG>C	c.(916-921)cctaagfs	p.P306fs	TNPO1_uc011csi.1_Non-coding_Transcript|TNPO1_uc011csj.1_Frame_Shift_Del_p.P256fs|TNPO1_uc003kci.4_Frame_Shift_Del_p.P298fs|TNPO1_uc003kcg.4_Frame_Shift_Del_p.P298fs|MIR4804_uc021yal.1_5'Flank	NM_002270	NP_694858	Q92973	TNPO1_HUMAN	Homo sapiens transportin 1 (TNPO1), transcript variant 1, mRNA.	306					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(6)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	36		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		AGGCATCTTCCTAAGTAAGTGTTC	0.343												
CETN3	1070	broad.mit.edu	37	5	89701581	89701581	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:89701580_89701580CT>C	uc003kjo.3	-	2	315	c.190_190AG>G	c.(190-192)gctfs	p.A64fs		NM_004365	NP_004356	O15182	CETN3_HUMAN	Homo sapiens centrin, EF-hand protein, 3 (CETN3), mRNA.	64	EF-hand 2.				cell division|centrosome cycle|mitosis	centriole	calcium ion binding			lung(3)	3		all_cancers(142;7.93e-09)|all_epithelial(76;2.13e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;1.42e-32)|Epithelial(54;1.45e-26)|all cancers(79;2.87e-23)		AGTACATCAGCTTTTTTTACA	0.313												
SEPT8	23176	broad.mit.edu	37	5	132096640	132096642	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:132096639_132096641TCTC>T	uc003kxr.2	-	8	1377_1379	c.1139_1141GAGA>A	c.(1138-1143)gagaag>gAag	p.K381del	SEPT8_uc003kxs.1_In_Frame_Del_p.K381del|SEPT8_uc003kxu.2_In_Frame_Del_p.K381del|SEPT8_uc011cxi.1_In_Frame_Del_p.K379del|SEPT8_uc003kxv.2_In_Frame_Del_p.K379del|SEPT8_uc003kxt.2_In_Frame_Del_p.K321del	NM_001098811	NP_001092281	Q92599	SEPT8_HUMAN	Homo sapiens septin 8 (SEPT8), transcript variant 1, mRNA.	381					cell cycle	septin complex	GTP binding|protein binding		SEPT8/AFF4(2)	kidney(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	11		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACCTTGCGCTTCTCCTCCTGGTG	0.626												
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139892957	139892958	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:139892956_139892957G>GA	uc003lfs.2	+	23	4363_4364	c.4209_4210G>GA	c.(4207-4212)ttgaaafs	p.L1403fs	ANKHD1-EIF4EBP3_uc003lfq.2_Frame_Shift_Ins_p.L1422fs|ANKHD1-EIF4EBP3_uc003lfr.3_Frame_Shift_Ins_p.L1403fs|ANKHD1-EIF4EBP3_uc003lft.1_Frame_Shift_Ins_p.L614fs|ANKHD1-EIF4EBP3_uc003lfu.1_Frame_Shift_Ins_p.L883fs|ANKHD1-EIF4EBP3_uc003lfv.1_Frame_Shift_Ins_p.L480fs|ANKHD1-EIF4EBP3_uc011czh.1_Frame_Shift_Ins_p.L142fs|ANKHD1-EIF4EBP3_uc003lfw.3_Frame_Shift_Ins_p.L41fs	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	Homo sapiens ANKHD1-EIF4EBP3 readthrough (ANKHD1-EIF4EBP3), mRNA.	1403						cytoplasm|nucleus	RNA binding			breast(1)|endometrium(8)|kidney(6)|large_intestine(14)|lung(17)|ovary(6)|prostate(2)|skin(1)|urinary_tract(2)	57			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAACTGTTGAAAAAATGTCA	0.347												
LARS	51520	broad.mit.edu	37	5	145508683	145508683	+	Splice_Site	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:145508682_145508682CT>C	uc003lnx.1	-	26	2867	c.2629_splice	c.e26-1	p.P877_splice	LARS_uc003lnw.1_Splice_Site_p.P35_splice|LARS_uc011dbq.1_Splice_Site_p.P831_splice|LARS_uc011dbr.1_Splice_Site_p.P823_splice|LARS_uc011dbs.1_Splice_Site_p.P850_splice	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	Homo sapiens leucyl-tRNA synthetase (LARS), mRNA.	877					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	TTGAGTCAGGCTTTTAAAAAA	0.333												
CNOT6	57472	broad.mit.edu	37	5	179994114	179994114	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr5:179994113_179994113GT>G	uc003mlx.3	+	7	1092	c.743_743GT>G	c.(742-744)agtfs	p.S248fs	CNOT6_uc010jld.3_Frame_Shift_Del_p.S248fs|CNOT6_uc010jle.3_Frame_Shift_Del_p.S243fs	NM_015455	NP_056270	Q9ULM6	CNOT6_HUMAN	Homo sapiens CCR4-NOT transcription complex, subunit 6 (CNOT6), mRNA.	248					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	RNA binding|exonuclease activity|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|skin(1)	23	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		CAGTATTACAGTTTTTTTCTG	0.348												
NOL7	51406	broad.mit.edu	37	6	13620992	13620993	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:13620991_13620992C>CA	uc003naz.3	+	7	738_739	c.706_707C>CA	c.(706-708)caafs	p.Q236fs		NM_016167	NP_057251	Q9UMY1	NOL7_HUMAN	Homo sapiens nucleolar protein 7, 27kDa (NOL7), mRNA.	236						mitochondrion|nucleolus		p.Q239fs*7(1)|p.K238fs*16(1)		breast(1)|large_intestine(3)|lung(1)	5	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.135)	Epithelial(50;0.176)			TCTAGGAATCCAAAAAAAACAA	0.267												
KIAA0319	9856	broad.mit.edu	37	6	24596508	24596509	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:24596507_24596508T>TC	uc011djo.2	-	2	894_895	c.394_395A>GA	c.(394-396)gacfs	p.D132fs	KIAA0319_uc011djp.2_Frame_Shift_Ins_p.D87fs|KIAA0319_uc003neh.1_Frame_Shift_Ins_p.D132fs|KIAA0319_uc011djq.1_Frame_Shift_Ins_p.D123fs|KIAA0319_uc011djr.1_Frame_Shift_Ins_p.D132fs	NM_001168375	NP_001161848	Q5VV43	K0319_HUMAN	Homo sapiens KIAA0319 (KIAA0319), transcript variant 2, mRNA.	132					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						CTCAGGTGAGTCCCCCCAGATC	0.550												
OR12D3	81797	broad.mit.edu	37	6	29342751	29342752	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:29342750_29342751C>CA	uc003nme.3	-	0	318_319	c.314_315G>TG	c.(313-315)ttgfs	p.L105fs		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	Homo sapiens olfactory receptor, family 12, subfamily D, member 3 (OR12D3), mRNA.	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						CTGTGCTTCCCAAAAAGTGGAA	0.495												
UHRF1BP1	54887	broad.mit.edu	37	6	34839369	34839369	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:34839368_34839368TC>T	uc003oju.4	+	18	4223	c.3989_3989TC>T	c.(3988-3990)atcfs	p.I1330fs	UHRF1BP1_uc010jvm.2_Non-coding_Transcript|UHRF1BP1_uc010jvn.3_Non-coding_Transcript|UHRF1BP1_uc010jvo.3_Non-coding_Transcript	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	Homo sapiens UHRF1 binding protein 1 (UHRF1BP1), mRNA.	1330										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						CAGGATGATATCCCCCCCATC	0.512												
PTCRA	171558	broad.mit.edu	37	6	42890866	42890866	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:42890865_42890865AC>A	uc021yzp.1	+	1	240	c.159_159AC>A	c.(157-159)gcafs	p.A53fs	PTCRA_uc011duz.1_Frame_Shift_Del_p.H64fs|PTCRA_uc010jxx.1_Intron|PTCRA_uc010jxy.3_Intron|PTCRA_uc003osx.3_Frame_Shift_Del_p.A53fs|PTCRA_uc010jxz.3_Intron	NM_001243168	NP_001230097	Q6ISU1	PTCRA_HUMAN	Homo sapiens pre T-cell antigen receptor alpha (PTCRA), transcript variant 1, mRNA.	53						integral to membrane	receptor activity	p.V52D(1)		large_intestine(2)|lung(4)|ovary(2)	8	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			TTGATGTTGCACCCCCTGGCC	0.607												
PLA2G7	7941	broad.mit.edu	37	6	46677134	46677134	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:46677133_46677133AT>A	uc010jzf.3	-	8	1069	c.800_800AT>T	c.(799-801)atafs	p.I267fs	PLA2G7_uc021zae.1_Frame_Shift_Del_p.I267fs	NM_005084	NP_005075	Q13093	PAFA_HUMAN	Homo sapiens phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (PLA2G7), transcript variant 1, mRNA.	267					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			AATTACTGCTATTTTTTCCCT	0.308												
BAI3	577	broad.mit.edu	37	6	69640508	69640508	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:69640507_69640507GA>G	uc010kak.3	+	2	1090	c.814_814GA>G	c.(814-816)gaafs	p.E272fs	BAI3_uc003pev.4_Frame_Shift_Del_p.E272fs	NM_001704	NP_001695	O60242	BAI3_HUMAN	Homo sapiens brain-specific angiogenesis inhibitor 3 (BAI3), mRNA.	272					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ATCTGTTCATGAAAAAAGGGT	0.338												
USP45	85015	broad.mit.edu	37	6	99893879	99893879	+	Frame_Shift_Del	DEL	A	A	-	rs12203426	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr6:99893878_99893878TA>T	uc003ppx.2	-	13	2303	c.1770_1770TA>A	c.(1768-1770)ttafs	p.L590fs	USP45_uc003ppv.2_Intron|USP45_uc003ppw.2_Frame_Shift_Del_p.L270fs	NM_001080481	NP_001073950	Q70EL2	UBP45_HUMAN	Homo sapiens ubiquitin specific peptidase 45 (USP45), mRNA.	590					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(2)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	22		all_cancers(76;0.000208)|Acute lymphoblastic leukemia(125;8.41e-11)|all_hematologic(75;2.56e-07)|all_epithelial(107;0.122)|Colorectal(196;0.133)		BRCA - Breast invasive adenocarcinoma(108;0.0718)		GCTTCCCCTCTAAAAAACATA	0.353												
CARD11	84433	broad.mit.edu	37	7	2968323	2968324	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:2968322_2968323C>CG	uc003smv.3	-	12	1997_1998	c.1663_1664G>CG	c.(1663-1665)cggfs	p.R555fs		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	Homo sapiens caspase recruitment domain family, member 11 (CARD11), mRNA.	555					T cell costimulation|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of cytokine production|regulation of apoptosis	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity	p.R548L(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GCTGCGGCTCCGGGGGGGCTGC	0.589			Mis		DLBCL							
GLI3	2737	broad.mit.edu	37	7	42064869	42064869	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:42064868_42064868GC>G	uc011kbh.2	-	8	1442	c.1351_1351GC>C	c.(1351-1353)cagfs	p.Q451fs	GLI3_uc011kbg.2_Frame_Shift_Del_p.Q392fs	NM_000168	NP_000159	P10071	GLI3_HUMAN	Homo sapiens GLI family zinc finger 3 (GLI3), mRNA.	451					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						CCTACCTGCTGCCCCCGAGCC	0.622									Pallister-Hall syndrome;Greig Cephalopolysyndactyly			
OGDH	4967	broad.mit.edu	37	7	44747228	44747229	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:44747227_44747228A>AC	uc003tln.3	+	21	3002_3003	c.2843_2844A>AC	c.(2842-2844)tacfs	p.Y948fs	OGDH_uc011kbx.2_Frame_Shift_Ins_p.Y944fs|OGDH_uc011kby.2_Frame_Shift_Ins_p.Y798fs|OGDH_uc003tlp.3_Frame_Shift_Ins_p.Y959fs|OGDH_uc011kbz.2_Frame_Shift_Ins_p.Y743fs	NM_002541	NP_002532	Q02218	ODO1_HUMAN	Homo sapiens oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	948					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	GTGCAGAAGTACCCCAATGCTG	0.564												
MLL5	55904	broad.mit.edu	37	7	104753027	104753028	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:104753026_104753027A>AT	uc003vcm.3	+	26	5357_5358	c.4823_4824A>AT	c.(4822-4824)catfs	p.H1608fs	MLL5_uc010ljc.3_Frame_Shift_Ins_p.H1608fs|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.3_Frame_Shift_Ins_p.H342fs	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) (MLL5), transcript variant 1, mRNA.	1608	Pro-rich.				DNA methylation|cell cycle arrest|cellular response to retinoic acid|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(13)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	63						ACTCCAGGGCATTTTTTGCCCT	0.535												
NUP205	23165	broad.mit.edu	37	7	135301911	135301912	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:135301910_135301911A>AT	uc003vsw.3	+	25	3636_3637	c.3605_3606A>AT	c.(3604-3606)gatfs	p.D1202fs		NM_015135	NP_055950	Q92621	NU205_HUMAN	Homo sapiens nucleoporin 205kDa (NUP205), mRNA.	1202					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TTGCAGTTGGATTTTTTTGATC	0.371												
MLL3	58508	broad.mit.edu	37	7	151878070	151878071	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr7:151878069_151878070T>TG	uc003wla.3	-	35	7094_7095	c.6875_6876A>CA	c.(6874-6876)ccafs	p.P2292fs	MLL3_uc003wkz.3_Frame_Shift_Ins_p.P1353fs|MLL3_uc003wky.3_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3), mRNA.	2292					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(6)|biliary_tract(9)|breast(24)|central_nervous_system(18)|cervix(6)|endometrium(31)|haematopoietic_and_lymphoid_tissue(1)|kidney(26)|large_intestine(52)|liver(1)|lung(102)|ovary(10)|pancreas(17)|prostate(15)|skin(20)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(8)|urinary_tract(15)	365	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GGGCAGCAGATGGGGAAACACG	0.520			N		medulloblastoma							
MTUS1	57509	broad.mit.edu	37	8	17513479	17513480	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:17513478_17513479G>GT	uc003wxv.3	-	8	3475_3476	c.3001_3002C>AC	c.(3001-3003)acafs	p.T1001fs	MTUS1_uc003wxt.3_Frame_Shift_Ins_p.T248fs|MTUS1_uc011kyg.2_Frame_Shift_Ins_p.T146fs|MTUS1_uc010lsy.3_Non-coding_Transcript|MTUS1_uc003wxw.3_Frame_Shift_Ins_p.T947fs|MTUS1_uc003wxs.3_Frame_Shift_Ins_p.T167fs	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	Homo sapiens microtubule associated tumor suppressor 1 (MTUS1), transcript variant 1, mRNA.	1001						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		CTCTCGTTCTGTTTTTTCAGCC	0.416												
FUT10	84750	broad.mit.edu	37	8	33246853	33246853	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:33246852_33246852CA>C	uc011lbi.2	-	3	1157	c.991_991TG>G	c.(991-993)gagfs	p.E331fs	FUT10_uc003xjc.3_Frame_Shift_Del_p.E288fs|FUT10_uc003xjd.3_Frame_Shift_Del_p.E253fs|FUT10_uc003xje.3_Frame_Shift_Del_p.E281fs|FUT10_uc003xjf.3_Frame_Shift_Del_p.E219fs|FUT10_uc003xjg.3_Frame_Shift_Del_p.E253fs|FUT10_uc003xjh.3_Frame_Shift_Del_p.E281fs			Q6P4F1	FUT10_HUMAN	Homo sapiens fucosyltransferase 10 (alpha (1,3) fucosyltransferase) (FUT10), mRNA.	281					L-fucose catabolic process|embryo development|fertilization|hemopoiesis|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	29				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		ACTGCATTCTCAAAAGCTAGG	0.458												
ST18	9705	broad.mit.edu	37	8	53055565	53055565	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:53055564_53055564CT>C	uc003xqz.2	-	11	2250	c.2094_2094AG>G	c.(2092-2094)aagfs	p.K698fs	ST18_uc011ldq.1_Frame_Shift_Del_p.K345fs|ST18_uc011ldr.1_Frame_Shift_Del_p.K663fs|ST18_uc011lds.1_Frame_Shift_Del_p.K603fs|ST18_uc003xra.2_Frame_Shift_Del_p.K698fs	NM_014682	NP_055497	O60284	ST18_HUMAN	Homo sapiens suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) (ST18), mRNA.	698						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CTCCAGGAAACTTTTTTTCCT	0.428												
STAU2	27067	broad.mit.edu	37	8	74507471	74507472	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:74507470_74507471A>AT	uc003xzm.3	-	10	1432_1433	c.1091_1092T>AT	c.(1090-1092)aatfs	p.N364fs	STAU2_uc011lfh.2_Frame_Shift_Ins_p.N260fs|STAU2_uc003xzn.3_Frame_Shift_Ins_p.N332fs|STAU2_uc011lfg.2_Frame_Shift_Ins_p.N192fs|STAU2_uc003xzo.3_Frame_Shift_Ins_p.N364fs|STAU2_uc003xzq.3_Frame_Shift_Ins_p.N144fs|STAU2_uc003xzp.3_Frame_Shift_Ins_p.N332fs|STAU2_uc011lfi.2_Frame_Shift_Ins_p.N326fs|STAU2_uc010lzk.3_Frame_Shift_Ins_p.N332fs|STAU2_uc010lzl.1_Frame_Shift_Ins_p.N192fs	NM_001164380	NP_001157855	Q9NUL3	STAU2_HUMAN	Homo sapiens staufen, RNA binding protein, homolog 2 (Drosophila) (STAU2), transcript variant 1, mRNA.	364	DRBM 4.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding	p.N332fs*67(1)|p.G364V(1)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)	19	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			CTTCTGCAGCATTTTTTTTGGC	0.327												
GDAP1	54332	broad.mit.edu	37	8	75263642	75263642	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:75263641_75263641GA>G	uc003yah.3	+	1	329	c.250_250GA>G	c.(250-252)gaafs	p.E84fs	GDAP1_uc011lfj.2_Intron|GDAP1_uc003yai.3_Frame_Shift_Del_p.E16fs	NM_018972	NP_001035808	Q8TB36	GDAP1_HUMAN	Homo sapiens ganglioside-induced differentiation-associated protein 1 (GDAP1), transcript variant 1, mRNA.	84	GST N-terminal.					cytoplasm				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)			TATCCACGGGGAAAACATAAT	0.433												
SLC26A7	115111	broad.mit.edu	37	8	92406218	92406218	+	Frame_Shift_Del	DEL	T	T	-	rs149495064		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:92406217_92406217AT>A	uc003yez.3	+	17	2124	c.1885_1885AT>A	c.(1885-1887)attfs	p.I629fs	SLC26A7_uc003yex.3_Frame_Shift_Del_p.I629fs|SLC26A7_uc003yey.3_Non-coding_Transcript|SLC26A7_uc003yfa.3_Frame_Shift_Del_p.I629fs	NM_134266	NP_599028	Q8TE54	S26A7_HUMAN	Homo sapiens solute carrier family 26, member 7 (SLC26A7), transcript variant 2, mRNA.	629	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AGAGAAACCAATTTTTTTTGA	0.338												
ESRP1	54845	broad.mit.edu	37	8	95683842	95683843	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:95683841_95683842T>TG	uc003ygq.4	+	10	1577_1578	c.1394_1395T>TG	c.(1393-1395)ctgfs	p.L465fs	ESRP1_uc003ygr.4_Frame_Shift_Ins_p.L465fs|ESRP1_uc003ygs.4_Frame_Shift_Ins_p.L465fs|ESRP1_uc003ygt.4_Frame_Shift_Ins_p.L465fs|ESRP1_uc003ygu.4_Frame_Shift_Ins_p.L465fs|ESRP1_uc003ygv.3_Frame_Shift_Ins_p.L305fs|ESRP1_uc003ygw.3_Frame_Shift_Ins_p.L305fs	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	Homo sapiens epithelial splicing regulatory protein 1 (ESRP1), transcript variant 1, mRNA.	465	RRM 3.				RNA splicing|mRNA processing|regulation of RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						CTGGATTTCCTGGGGGAGTTCG	0.446												
RIMS2	9699	broad.mit.edu	37	8	104927779	104927779	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:104927778_104927778TA>T	uc003yls.3	+	4	1443	c.1202_1202TA>T	c.(1201-1203)gtafs	p.V401fs	RIMS2_uc003ylp.3_Frame_Shift_Del_p.V623fs|RIMS2_uc003ylw.2_Frame_Shift_Del_p.V431fs|RIMS2_uc003ylq.3_Frame_Shift_Del_p.V431fs|RIMS2_uc003ylr.3_Frame_Shift_Del_p.V478fs|RIMS2_uc003ylt.3_Frame_Shift_Del_p.V24fs|RIMS2_uc003ylu.1_Frame_Shift_Del_p.V14fs|RIMS2_uc003ylv.1_Frame_Shift_Del_p.V14fs	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	Homo sapiens regulating synaptic membrane exocytosis 2 (RIMS2), transcript variant 2, mRNA.	701					intracellular protein transport	cell junction|presynaptic membrane	Rab GTPase binding|metal ion binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATTACTAAAGTAAAAAAAGGA	0.323										HNSCC(12;0.0054)		
EIF2C2	27161	broad.mit.edu	37	8	141554345	141554346	+	Frame_Shift_Ins	INS	-	-	G	rs148575703	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr8:141554344_141554345C>CG	uc003yvn.3	-	13	1847_1848	c.1806_1807G>CG	c.(1804-1809)cccgccfs	p.P602fs	EIF2C2_uc010meo.3_Frame_Shift_Ins_p.P602fs|EIF2C2_uc010men.3_Frame_Shift_Ins_p.P525fs	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	Homo sapiens eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 1, mRNA.	602	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	RNA-induced silencing complex|cytoplasmic mRNA processing body|cytosol|mRNA cap binding complex|micro-ribonucleoprotein complex|nucleus|polysome	RNA 7-methylguanosine cap binding|endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|siRNA binding|translation initiation factor activity			NS(1)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	33	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			CCATCCCCGGCGGGGGGGTGAG	0.644												
TYRP1	7306	broad.mit.edu	37	9	12702411	12702414	+	Frame_Shift_Del	DEL	ACAA	ACAA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:12702410_12702413TACAA>T	uc003zkv.4	+	4	1231_1234	c.1053_1056TACAA>T	c.(1051-1056)tctacafs	p.S351fs		NM_000550	NP_000541	P17643	TYRP1_HUMAN	Homo sapiens tyrosinase-related protein 1 (TYRP1), mRNA.	351					melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity	p.N353fs*31(2)		NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|stomach(1)	22		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		ATTCCAACTCTACAAACAGTTTCC	0.387									Oculocutaneous Albinism			
BNC2	54796	broad.mit.edu	37	9	16436375	16436375	+	Frame_Shift_Del	DEL	G	G	-	rs142872531		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:16436374_16436374CG>C	uc003zml.3	-	5	1958	c.1818_1818CG>G	c.(1816-1818)ccgfs	p.P606fs	BNC2_uc011lmw.2_Frame_Shift_Del_p.P511fs|BNC2_uc003zmm.3_Frame_Shift_Del_p.P564fs|BNC2_uc003zmq.1_Frame_Shift_Del_p.P620fs|BNC2_uc003zmr.1_Frame_Shift_Del_p.P643fs|BNC2_uc003zmp.1_Frame_Shift_Del_p.P634fs|BNC2_uc010mij.1_Frame_Shift_Del_p.P528fs|BNC2_uc011lmv.2_Frame_Shift_Del_p.P432fs|BNC2_uc003zmo.1_Frame_Shift_Del_p.P528fs|BNC2_uc003zmj.3_Frame_Shift_Del_p.P371fs|BNC2_uc003zmk.3_Non-coding_Transcript|BNC2_uc003zmi.3_Frame_Shift_Del_p.P371fs|BNC2_uc003zmn.1_Frame_Shift_Del_p.P371fs	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	Homo sapiens basonuclin 2 (BNC2), mRNA.	606	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CAGAGGGTGGCGGGGGGTGCT	0.567												
RNF38	152006	broad.mit.edu	37	9	36342424	36342424	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:36342423_36342423TA>T	uc003zzh.3	-	11	1577	c.1386_splice	c.e11-1	p.L462_splice	RNF38_uc003zzi.3_Splice_Site_p.L412_splice|RNF38_uc003zzj.3_Splice_Site_p.L379_splice|RNF38_uc003zzk.3_Splice_Site_p.L379_splice|RNF38_uc003zzl.3_Splice_Site_p.L386_splice|RNF38_uc003zzm.3_Splice_Site_p.L379_splice	NM_022781	NP_919313	Q9H0F5	RNF38_HUMAN	Homo sapiens ring finger protein 38 (RNF38), transcript variant 1, mRNA.	462							zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			ACTACACACCTAAAAAAAGCA	0.358												
RG9MTD3	158234	broad.mit.edu	37	9	37763633	37763633	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:37763632_37763632GC>G	uc004aai.3	+	3	379	c.302_302GC>G	c.(301-303)tgcfs	p.C101fs	RG9MTD3_uc011lqo.2_Frame_Shift_Del_p.C101fs|RG9MTD3_uc011lqp.2_Intron|RG9MTD3_uc011lqq.2_Intron|RG9MTD3_uc004aaj.3_Non-coding_Transcript|RG9MTD3_uc004aak.3_Frame_Shift_Del_p.C6fs	NM_144964	NP_659401	Q6PF06	RG9D3_HUMAN	Homo sapiens RNA (guanine-9-) methyltransferase domain containing 3 (RG9MTD3), mRNA.	101							methyltransferase activity			endometrium(1)|large_intestine(2)|lung(1)	4				GBM - Glioblastoma multiforme(29;0.00817)|Lung(182;0.226)		TTAGGCATTTGCCCCCAGCAC	0.383												
SECISBP2	79048	broad.mit.edu	37	9	91956315	91956316	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:91956314_91956315T>TG	uc004aqj.1	+	9	1435_1436	c.1355_1356T>TG	c.(1354-1356)ttgfs	p.L452fs	SECISBP2_uc010mqo.1_Frame_Shift_Ins_p.L157fs|SECISBP2_uc004aqk.1_Frame_Shift_Ins_p.L379fs|SECISBP2_uc011ltk.1_Frame_Shift_Ins_p.L451fs|SECISBP2_uc011ltl.1_Frame_Shift_Ins_p.L384fs	NM_024077	NP_076982	Q96T21	SEBP2_HUMAN	Homo sapiens SECIS binding protein 2 (SECISBP2), mRNA.	452					translation	nucleus	mRNA 3'-UTR binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(3)|skin(2)	32						CAGTTGGACTTGGGGGGCATGC	0.421												
PALM2-AKAP2	445815	broad.mit.edu	37	9	112898790	112898790	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:112898789_112898789GC>G	uc004bei.2	+	8	1853	c.1661_1661GC>G	c.(1660-1662)agcfs	p.S554fs	PALM2-AKAP2_uc004bej.4_Frame_Shift_Del_p.S322fs|PALM2-AKAP2_uc004bek.4_Frame_Shift_Del_p.S322fs|PALM2-AKAP2_uc004bel.1_Frame_Shift_Del_p.S132fs|PALM2-AKAP2_uc011lwi.2_Frame_Shift_Del_p.S180fs|PALM2-AKAP2_uc004bem.3_Frame_Shift_Del_p.S180fs|PALM2-AKAP2_uc010mtw.1_Frame_Shift_Del_p.S140fs|PALM2-AKAP2_uc011lwj.2_Frame_Shift_Del_p.S91fs|PALM2-AKAP2_uc004ben.3_Frame_Shift_Del_p.S91fs	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 2 (AKAP2), transcript variant 2, mRNA.	91							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						GGCGGCCTAAGCCCCCCTGTC	0.602												
GOLGA1	2800	broad.mit.edu	37	9	127684160	127684160	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:127684159_127684159CT>C	uc004bpc.3	-	8	916	c.574_574AG>G	c.(574-576)gaafs	p.E192fs	GOLGA1_uc010mws.3_Non-coding_Transcript|GOLGA1_uc010mwt.1_Frame_Shift_Del_p.E167fs	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	Homo sapiens golgin A1 (GOLGA1), mRNA.	192						Golgi cisterna membrane				NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	20						AGACTTTCTTCTTTTTTTAAA	0.408												
FUBP3	8939	broad.mit.edu	37	9	133506014	133506015	+	Splice_Site	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:133506013_133506014A>AG	uc004bzr.1	+	13	1226	c.1118_splice	c.e13-1	p.G373_splice		NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	Homo sapiens far upstream element (FUSE) binding protein 3 (FUBP3), mRNA.	373	KH 4.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		TGCTGTCCGCAGGGGGTGAGAA	0.589												
SETX	23064	broad.mit.edu	37	9	135203509	135203509	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr9:135203508_135203508CT>C	uc004cbk.3	-	9	3660	c.3477_3477AG>G	c.(3475-3477)aagfs	p.K1159fs	SETX_uc004cbj.3_Frame_Shift_Del_p.K778fs|SETX_uc010mzt.3_Frame_Shift_Del_p.K778fs	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	Homo sapiens senataxin (SETX), mRNA.	1159					RNA processing|cell death|double-strand break repair	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TTCTCTTAGGCTTTTTTACTT	0.388												
IDI1	3422	broad.mit.edu	37	10	1087271	1087272	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:1087270_1087271C>CT	uc001iga.3	-	4	829_830	c.711_712G>AG	c.(709-714)aaagaafs	p.K237fs	IDI2-AS1_uc010qaf.1_Intron|IDI2-AS1_uc001ifx.3_Intron|IDI2-AS1_uc001ifw.3_Intron|IDI2-AS1_uc001ify.3_Intron|IDI1_uc001ifz.3_Frame_Shift_Ins_p.K181fs|IDI1_uc001igb.3_Non-coding_Transcript|IDI1_uc001igc.3_Frame_Shift_Ins_p.K181fs	NM_004508	NP_004499	Q13907	IDI1_HUMAN	Homo sapiens isopentenyl-diphosphate delta isomerase 1 (IDI1), mRNA.	180					carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding			large_intestine(3)|lung(2)|prostate(1)	6		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.221)	Epithelial(11;0.0972)		TTCAGAAGTTCTTTTAGTTCTT	0.327												
KIN	22944	broad.mit.edu	37	10	7817765	7817765	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:7817764_7817764TA>T	uc001ijt.3	-	6	653	c.559_splice	c.e6-1	p.E187_splice	KIN_uc010qaz.2_Splice_Site|KIN_uc010qba.2_Splice_Site_p.E81_splice	NM_012311	NP_036443	O60870	KIN17_HUMAN	Homo sapiens KIN, antigenic determinant of recA protein homolog (mouse) (KIN), transcript variant 1, mRNA.	187					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	RNA binding|double-stranded DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						AGGGACCTCCTAAAAAAAAGA	0.318												
GATA3	2625	broad.mit.edu	37	10	8115780	8115780	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:8115779_8115779CA>C	uc001ijz.3	+	5	1685	c.1128_1128CA>C	c.(1126-1128)tgcfs	p.C376fs	GATA3_uc001ika.3_Frame_Shift_Del_p.C375fs	NM_001002295	NP_001002295	P23771	GATA3_HUMAN	Homo sapiens GATA binding protein 3 (GATA3), transcript variant 1, mRNA.	375					T cell receptor signaling pathway|TOR signaling cascade|aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of T cell differentiation|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						CCAAAAAGTGCAAAAAAGTGC	0.463			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""					
CACNB2	783	broad.mit.edu	37	10	18828599	18828600	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:18828598_18828599C>CA	uc001ipr.2	+	13	1988_1989	c.1928_1929C>CA	c.(1927-1929)tcafs	p.S643fs	CACNB2_uc001ipt.2_Frame_Shift_Ins_p.S605fs|CACNB2_uc009xjz.1_Frame_Shift_Ins_p.S393fs|CACNB2_uc001ips.2_Frame_Shift_Ins_p.S619fs|CACNB2_uc001ipu.3_Frame_Shift_Ins_p.S615fs|CACNB2_uc001ipv.3_Frame_Shift_Ins_p.S591fs|CACNB2_uc009xka.2_Frame_Shift_Ins_p.S577fs|CACNB2_uc001ipw.2_Frame_Shift_Ins_p.S550fs|CACNB2_uc001ipx.2_Frame_Shift_Ins_p.S588fs|CACNB2_uc001ipz.2_Frame_Shift_Ins_p.S565fs|CACNB2_uc001ipy.2_Frame_Shift_Ins_p.S589fs|CACNB2_uc010qco.1_Frame_Shift_Ins_p.S557fs|CACNB2_uc001iqa.2_Frame_Shift_Ins_p.S595fs|NSUN6_uc001iqb.3_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	Homo sapiens calcium channel, voltage-dependent, beta 2 subunit (CACNB2), transcript variant 2, mRNA.	643					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GAAGTGATATCAAAAAAACGGA	0.450												
PIP4K2A	5305	broad.mit.edu	37	10	22830828	22830828	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:22830827_22830827TG>T	uc001irl.4	-	7	1190	c.942_942CA>A	c.(940-942)ccafs	p.P314fs	PIP4K2A_uc010qcu.2_Frame_Shift_Del_p.P174fs	NM_005028	NP_005019	P48426	PI42A_HUMAN	Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP4K2A), mRNA.	314	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						CGGGGCTATCTGGGGGGGTTC	0.582												
GPR158	57512	broad.mit.edu	37	10	25887916	25887917	+	Frame_Shift_Ins	INS	-	-	C	rs147989919	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:25887915_25887916G>GC	uc001isj.3	+	10	3420_3421	c.3360_3361G>GC	c.(3358-3363)ctgcccfs	p.L1120fs	GPR158_uc001isk.3_Frame_Shift_Ins_p.L495fs	NM_020752	NP_065803	Q5T848	GP158_HUMAN	Homo sapiens G protein-coupled receptor 158 (GPR158), mRNA.	1120						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GCGAAGAACTGCCCCCCAAAGC	0.485												
ANKRD26	22852	broad.mit.edu	37	10	27295869	27295869	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:27295868_27295868AT>A	uc009xku.1	-	32	5149	c.4977_4977AT>T	c.(4975-4977)aatfs	p.N1659fs	ANKRD26_uc001itg.2_Frame_Shift_Del_p.N1345fs|ANKRD26_uc001ith.2_Frame_Shift_Del_p.N1658fs	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	Homo sapiens ankyrin repeat domain 26 (ANKRD26), transcript variant 1, mRNA.	1658						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						CTCTAGTTATATTTTTTTCCA	0.274												
JMJD1C	221037	broad.mit.edu	37	10	64950825	64950828	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:64950824_64950827CTCTT>C	uc001jmn.3	-	16	6418_6421	c.6118_6121AAGAG>G	c.(6118-6123)agagaafs	p.R2040fs	JMJD1C_uc001jml.3_Frame_Shift_Del_p.R1803fs|JMJD1C_uc001jmm.3_Frame_Shift_Del_p.R1752fs|JMJD1C_uc010qiq.2_Frame_Shift_Del_p.R1858fs|JMJD1C_uc009xpi.3_Frame_Shift_Del_p.R1858fs|JMJD1C_uc009xpj.2_Non-coding_Transcript|JMJD1C_uc001jmo.3_5'UTR	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	Homo sapiens jumonji domain containing 1C (JMJD1C), transcript variant 1, mRNA.	2040					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTGTCTTGTTCTCTTTCTTCTTTA	0.368												
SH3PXD2A	9644	broad.mit.edu	37	10	105363001	105363002	+	Frame_Shift_Ins	INS	-	-	G	rs11818820		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:105363000_105363001T>TG	uc010qqu.1	-	11	1786_1787	c.1719_1720A>CA	c.(1717-1722)cccaaafs	p.P573fs	SH3PXD2A_uc010qqr.2_Intron|SH3PXD2A_uc010qqs.1_Frame_Shift_Ins_p.P465fs|SH3PXD2A_uc010qqt.1_Frame_Shift_Ins_p.P507fs|SH3PXD2A_uc009xxn.1_Frame_Shift_Ins_p.P465fs|SH3PXD2A_uc001kxj.1_Frame_Shift_Ins_p.P630fs	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	Homo sapiens SH3 and PX domains 2A (SH3PXD2A), mRNA.	658					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding	p.R572W(2)		breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		GAGCCTGATTTGGGGGAGTTTT	0.584												
PRDX3	10935	broad.mit.edu	37	10	120936634	120936635	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr10:120936633_120936634G>GC	uc001lec.3	-	1	111_112	c.68_69C>GC	c.(67-69)ggcfs	p.G23fs	PRDX3_uc021pzp.1_Frame_Shift_Ins_p.G23fs	NM_006793	NP_006784	P30048	PRDX3_HUMAN	Homo sapiens peroxiredoxin 3 (PRDX3), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	23					cell redox homeostasis|hydrogen peroxide catabolic process|mitochondrion organization|myeloid cell differentiation|negative regulation of kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of cell proliferation|regulation of mitochondrial membrane potential|response to lipopolysaccharide	early endosome|mitochondrion	alkyl hydroperoxide reductase activity|caspase inhibitor activity|peroxidase activity|peroxiredoxin activity|protein C-terminus binding|protein kinase binding	p.I24fs*50(1)		endometrium(1)|lung(2)	3		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0245)		TGGCAGAAATGCCCCAAGGAAT	0.475												
EPS8L2	64787	broad.mit.edu	37	11	723305	723305	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:723304_723304AC>A	uc001lqt.3	+	14	1652	c.1405_1405AC>A	c.(1405-1407)accfs	p.T469fs	EPS8L2_uc001lqu.3_Frame_Shift_Del_p.T469fs|EPS8L2_uc010qwk.2_Frame_Shift_Del_p.T485fs|EPS8L2_uc001lqv.3_Frame_Shift_Del_p.T424fs|EPS8L2_uc001lqw.3_Frame_Shift_Del_p.T81fs|EPS8L2_uc001lqx.3_Frame_Shift_Del_p.T81fs|EPS8L2_uc001lqy.3_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	Homo sapiens EPS8-like 2 (EPS8L2), mRNA.	469						cytoplasm		p.D473fs*30(1)		NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTCAGAGCCCACCCCCCCGGG	0.587											OREG0020659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
TALDO1	6888	broad.mit.edu	37	11	755877	755885	+	Splice_Site	DEL	AGCCATCGA	AGCCATCGA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:755876_755884TAGCCATCGA>T	uc001lqz.3	+	2	148	c.98_splice	c.e2-1	p.A33_splice	TALDO1_uc010qwl.2_Splice_Site_p.A33_splice|TALDO1_uc001lra.3_Splice_Site_p.A33_splice	NM_006755	NP_006746	P37837	TALDO_HUMAN	Homo sapiens transaldolase 1 (TALDO1), mRNA.	33					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		ACTATTTCCCTAGCCATCGACGAGTACAA	0.541												
PGAP2	27315	broad.mit.edu	37	11	3846303	3846305	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:3846302_3846304CCTT>C	uc010qxw.2	+	6	957_959	c.932_934CCTT>C	c.(931-936)tccttc>tCtc	p.F313del	PGAP2_uc001lyl.3_In_Frame_Del_p.F213del|PGAP2_uc010qxy.2_In_Frame_Del_p.F248del|PGAP2_uc001lyn.4_In_Frame_Del_p.146_147LL>L|PGAP2_uc010qya.2_Non-coding_Transcript|PGAP2_uc010qyb.2_In_Frame_Del_p.196_197LL>L|PGAP2_uc001lys.3_In_Frame_Del_p.F256del|PGAP2_uc001lyt.3_In_Frame_Del_p.F39del|PGAP2_uc021qcm.1_In_Frame_Del_p.F195del	NM_014489	NP_055304	Q9UHJ9	PGAP2_HUMAN	Homo sapiens post-GPI attachment to proteins 2 (PGAP2), transcript variant 1, mRNA.	256					GPI anchor biosynthetic process	Golgi membrane|endoplasmic reticulum membrane|integral to membrane	protein transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|urinary_tract(1)	11						AACTTCATCTCCTTCTTCTCGGC	0.552											OREG0020703	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
OR51L1	119682	broad.mit.edu	37	11	5020584	5020585	+	Frame_Shift_Ins	INS	-	-	T	rs146166863	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:5020583_5020584G>GT	uc010qyu.2	+	0	371_372	c.371_372G>GT	c.(370-372)cgtfs	p.R124fs		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily L, member 1 (OR51L1), mRNA.	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R124H(2)|p.R124L(2)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCTTTGACCGTTTTGTTGCTA	0.505												
AMPD3	272	broad.mit.edu	37	11	10500145	10500146	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:10500144_10500145G>GC	uc001min.1	+	2	665_666	c.320_321G>GC	c.(319-321)ggcfs	p.G107fs	AMPD3_uc010rbz.1_Intron|AMPD3_uc009yfw.1_Non-coding_Transcript|AMPD3_uc009yfx.1_Frame_Shift_Ins_p.G98fs|AMPD3_uc001mio.1_Frame_Shift_Ins_p.G98fs|AMPD3_uc009yfz.2_Non-coding_Transcript|AMPD3_uc001mip.1_Frame_Shift_Ins_p.G105fs|AMPD3_uc009yfy.2_Frame_Shift_Ins_p.G98fs	NM_000480	NP_001165902	Q01432	AMPD3_HUMAN	Homo sapiens adenosine monophosphate deaminase 3 (AMPD3), transcript variant 1, mRNA.	98					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		GATTGGAAGGGCCCCCCGGCAG	0.579												
MAPK8IP1	9479	broad.mit.edu	37	11	45926551	45926551	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:45926550_45926550TA>T	uc001nbr.3	+	9	2247	c.1922_1922TA>T	c.(1921-1923)ttafs	p.L641fs		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	Homo sapiens mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1), mRNA.	641	PID.				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	MAP-kinase scaffold activity|kinesin binding|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		TTTTTCCAGTTAAAAAACATC	0.522												
C11orf94	143678	broad.mit.edu	37	11	45928456	45928457	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:45928455_45928456A>AG	uc001nbs.4	-	1	176_177	c.139_140T>CT	c.(139-141)ctgfs	p.L47fs		NM_001080446	NP_001073915	C9JXX5	CK094_HUMAN	Homo sapiens chromosome 11 open reading frame 94 (C11orf94), mRNA.	47						extracellular region				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|ovary(1)|pancreas(1)|prostate(1)	7						CGAGAGTTCCAGGGGGGCGGAA	0.619												
CELF1	10658	broad.mit.edu	37	11	47494745	47494746	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:47494744_47494745T>TG	uc001nfp.3	-	13	1714_1715	c.1312_1313A>CA	c.(1312-1314)cagfs	p.Q438fs	CELF1_uc001nfl.3_Frame_Shift_Ins_p.Q410fs|CELF1_uc010rhm.2_Frame_Shift_Ins_p.Q409fs|CELF1_uc001nfm.3_Frame_Shift_Ins_p.Q407fs|CELF1_uc001nfk.2_Frame_Shift_Ins_p.Q436fs|CELF1_uc001nfn.3_Frame_Shift_Ins_p.Q406fs|CELF1_uc001nfr.1_Frame_Shift_Ins_p.Q410fs	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	Homo sapiens CUGBP, Elav-like family member 1 (CELF1), transcript variant 3, mRNA.	410	RRM 3.				RNA interference|embryo development|mRNA splice site selection|regulation of RNA splicing	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)	18						ACCAAACTCCTGGGGCAGGTGG	0.500												
OR4A16	81327	broad.mit.edu	37	11	55111419	55111420	+	Frame_Shift_Ins	INS	-	-	T	rs141537673		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:55111418_55111419G>GT	uc010rie.2	+	0	742_743	c.742_743G>GT	c.(742-744)gttfs	p.V248fs		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily A, member 16 (OR4A16), mRNA.	248					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GGTTGCCCTCGTTTTTGTTCCC	0.396												
CCDC88B	283234	broad.mit.edu	37	11	64111891	64111892	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:64111890_64111891G>GA	uc001nzy.3	+	13	1926_1927	c.1877_1878G>GA	c.(1876-1878)ggafs	p.G626fs	CCDC88B_uc009ypo.2_Frame_Shift_Ins_p.G623fs|CCDC88B_uc001nzz.1_Frame_Shift_Ins_p.G275fs	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	Homo sapiens coiled-coil domain containing 88B (CCDC88B), mRNA.	626					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GAGACAGAGGGAAGAGAGGCTC	0.653												
MEN1	4221	broad.mit.edu	37	11	64575083	64575084	+	Frame_Shift_Ins	INS	-	-	CA			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:64575082_64575083G>GCA	uc001obj.3	-	3	812_813	c.739_740C>TGC	c.(739-741)gccfs	p.A247fs	MEN1_uc001obk.3_Frame_Shift_Ins_p.A247fs|MEN1_uc001obl.3_Frame_Shift_Ins_p.A207fs|MEN1_uc001obm.3_Frame_Shift_Ins_p.A242fs|MEN1_uc001obn.3_Frame_Shift_Ins_p.A247fs|MEN1_uc001obo.3_Frame_Shift_Ins_p.A247fs|MEN1_uc001obq.3_Frame_Shift_Ins_p.A247fs|MEN1_uc001obr.3_Frame_Shift_Ins_p.A247fs	NM_130800	NP_570716	O00255	MEN1_HUMAN	Homo sapiens multiple endocrine neoplasia I (MEN1), transcript variant e1B, mRNA.	247	Interaction with FANCD2.		A -> V (in MEN1; almost complete loss of histone methylation; loss of JUND- binding; no repression of JUND transactivation).		DNA repair|MAPKKK cascade|histone lysine methylation|negative regulation of JNK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to UV|response to gamma radiation|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	R-SMAD binding|Y-form DNA binding|double-stranded DNA binding|four-way junction DNA binding|protein N-terminus binding|protein binding, bridging|transcription regulatory region DNA binding	p.A242_I247del(2)|p.C241fs*39(1)		NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						AGGGTTGATGGCACACACCATG	0.569			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated			
SLC25A45	283130	broad.mit.edu	37	11	65146856	65146856	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:65146855_65146855AC>A	uc001odr.1	-	4	535	c.331_331GT>T	c.(331-333)ttcfs	p.F111fs	SLC25A45_uc009yqi.1_Intron|SLC25A45_uc001odq.1_Frame_Shift_Del_p.F87fs|SLC25A45_uc001ods.1_Frame_Shift_Del_p.F69fs|SLC25A45_uc001odt.1_Frame_Shift_Del_p.F69fs	NM_182556	NP_001070709	Q8N413	S2545_HUMAN	Homo sapiens solute carrier family 25, member 45 (SLC25A45), transcript variant 1, mRNA.	111					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding	p.G110W(1)		endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14						ACCTGCAGGAACCCCCCGGTG	0.657												
SHANK2	22941	broad.mit.edu	37	11	70507741	70507742	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:70507740_70507741C>CT	uc001oqc.3	-	12	1816_1817	c.1704_1705G>AG	c.(1702-1707)aaagacfs	p.K568fs	SHANK2_uc010rqn.2_Frame_Shift_Ins_p.K44fs|SHANK2_uc001opz.3_Frame_Shift_Ins_p.K44fs|BC127192_uc009ysn.1_Intron|SHANK2_uc010rqp.1_Frame_Shift_Ins_p.K44fs	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	Homo sapiens SH3 and multiple ankyrin repeat domains 2 (SHANK2), transcript variant 1, mRNA.	253					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|SH3 domain binding|ionotropic glutamate receptor binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCCTCATTGTCTTTTTTCTGCA	0.510												
C2CD3	26005	broad.mit.edu	37	11	73829364	73829364	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:73829363_73829363AT>A	uc001ouu.2	-	8	1657	c.1430_1430AT>T	c.(1429-1431)atafs	p.I477fs	C2CD3_uc001ouv.2_Frame_Shift_Del_p.I477fs	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	Homo sapiens C2 calcium-dependent domain containing 3 (C2CD3), mRNA.	477						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					TGACTGGCTTATTTTTTTAGA	0.428												
AMICA1	120425	broad.mit.edu	37	11	118068766	118068768	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:118068765_118068767GTCT>G	uc001psk.2	-	7	1125_1127	c.951_953AGAC>C	c.(949-954)aagact>aaCt	p.317_318KT>N	AMICA1_uc001psg.2_In_Frame_Del_p.127_128KT>N|AMICA1_uc001psh.2_In_Frame_Del_p.278_279KT>N|AMICA1_uc009yzw.1_Non-coding_Transcript|AMICA1_uc001psi.2_In_Frame_Del_p.307_308KT>N|AMICA1_uc010rxw.1_In_Frame_Del_p.278_279KT>N|AMICA1_uc010rxx.1_In_Frame_Del_p.317_318KT>N|AMICA1_uc001psl.1_In_Frame_Del_p.273_274KT>N	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	Homo sapiens adhesion molecule, interacts with CXADR antigen 1 (AMICA1), transcript variant 1, mRNA.	317					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CTCTGGATTAGTCTTCTTCGTGT	0.443											OREG0021382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
DPAGT1	1798	broad.mit.edu	37	11	118969143	118969144	+	Frame_Shift_Ins	INS	-	-	A	rs35482889		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:118969142_118969143G>GA	uc001pvi.3	-	4	1118_1119	c.698_699C>TC	c.(697-699)ttcfs	p.F233fs	H2AFX_uc001pvg.3_5'Flank|DPAGT1_uc001pvj.3_Frame_Shift_Ins_p.F126fs|DPAGT1_uc001pvk.3_Frame_Shift_Ins_p.F61fs|DPAGT1_uc001pvm.1_Frame_Shift_Ins_p.F126fs|DPAGT1_uc010rza.2_Frame_Shift_Ins_p.F126fs	NM_001382	NP_001373	Q9H3H5	GPT_HUMAN	Homo sapiens dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) (DPAGT1), mRNA.	233					dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity|phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups	p.?(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	17	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		CCAAAGTGGTGAAAAAAAAGGG	0.441												
FLI1	2313	broad.mit.edu	37	11	128680805	128680806	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr11:128680804_128680805C>CG	uc010sbu.2	+	8	1623_1624	c.1280_1281C>CG	c.(1279-1281)acgfs	p.T427fs	FLI1_uc010sbt.2_Frame_Shift_Ins_p.T234fs|FLI1_uc010sbv.2_Frame_Shift_Ins_p.T394fs|FLI1_uc009zci.3_Frame_Shift_Ins_p.T361fs	NM_002017	NP_001161153	Q01543	FLI1_HUMAN	Homo sapiens Friend leukemia virus integration 1 (FLI1), transcript variant 1, mRNA.	427					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		ACCTCCCCCACGGGGGGAATCT	0.564			T	EWSR1	Ewing sarcoma							
RAD51AP1	10635	broad.mit.edu	37	12	4668106	4668107	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:4668105_4668106C>CT	uc001qmw.3	+	9	1161_1162	c.1005_1006C>CT	c.(1003-1008)ggcttgfs	p.G335fs	RAD51AP1_uc001qmu.3_Frame_Shift_Ins_p.G318fs|RAD51AP1_uc010sep.2_Frame_Shift_Ins_p.G216fs|RAD51AP1_uc010seq.2_Frame_Shift_Ins_p.G216fs|RAD51AP1_uc009zeg.3_Non-coding_Transcript	NM_001130862	NP_001124334	Q96B01	R51A1_HUMAN	Homo sapiens RAD51 associated protein 1 (RAD51AP1), transcript variant 1, mRNA.	335	Interaction with RAD51.				double-strand break repair via homologous recombination		RNA binding|double-stranded DNA binding|protein binding|single-stranded DNA binding	p.L319M(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			TCCGCCTTGGCTTGTCCAGATT	0.490												
DYRK4	8798	broad.mit.edu	37	12	4719362	4719362	+	Frame_Shift_Del	DEL	A	A	-	rs80196697		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:4719361_4719361GA>G	uc009zeh.1	+	12	1443	c.1401_1401GA>G	c.(1399-1401)gggfs	p.G467fs	DYRK4_uc001qmx.3_Frame_Shift_Del_p.G352fs|DYRK4_uc001qmy.2_Frame_Shift_Del_p.G352fs|DYRK4_uc021qtq.1_Frame_Shift_Del_p.G206fs|DYRK4_uc001qmz.2_Frame_Shift_Del_p.G66fs|DYRK4_uc001qna.2_5'UTR|DYRK4_uc010ser.2_5'UTR	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (DYRK4), mRNA.	352						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.G754G(1)		central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			ACAACAGGGGGAAAAAAAGAT	0.393												
ZNF384	171017	broad.mit.edu	37	12	6787521	6787521	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:6787520_6787520AG>A	uc010sfh.2	-	5	729	c.459_459CT>T	c.(457-459)cctfs	p.P153fs	ZNF384_uc001qqa.3_Frame_Shift_Del_p.P153fs|ZNF384_uc001qqd.3_Intron|ZNF384_uc009zew.1_Frame_Shift_Del_p.P8fs	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	Homo sapiens zinc finger protein 384 (ZNF384), transcript variant 7, mRNA.	153					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						CTTGTGAGCCAGGGGGAAGAG	0.582			T	"""EWSR1, TAF15 """	ALL							
KLRC2	3822	broad.mit.edu	37	12	10587929	10587929	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:10587928_10587928GT>G	uc001qyh.3	-	1	276	c.269_269AC>C	c.(268-270)acafs	p.T90fs	KLRC2_uc010she.1_Frame_Shift_Del_p.T90fs|KLRC2_uc001qyk.2_Frame_Shift_Del_p.T90fs	NM_002261	NP_002252	P26717	NKG2C_HUMAN	Homo sapiens killer cell lectin-like receptor subfamily C, member 3 (KLRC3), transcript variant 1, mRNA.	90					cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity			kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11						AAGAACTATTGTTTTTAACAC	0.398												
HEBP1	50865	broad.mit.edu	37	12	13128322	13128322	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:13128321_13128321TC>T	uc001rbd.3	-	3	686	c.491_491GA>A	c.(490-492)gacfs	p.D164fs		NM_015987	NP_057071	Q9NRV9	HEBP1_HUMAN	Homo sapiens heme binding protein 1 (HEBP1), mRNA.	164					circadian rhythm	extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	7		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		GAAGTAGATGTCCCCCCGGTA	0.582												
ATF7IP	55729	broad.mit.edu	37	12	14577802	14577803	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:14577801_14577802G>GA	uc001rbw.3	+	1	1110_1111	c.952_953G>GA	c.(952-954)gaafs	p.E318fs	ATF7IP_uc010shs.1_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rbu.3_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rbv.1_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rbx.3_Frame_Shift_Ins_p.E318fs|ATF7IP_uc010sht.1_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rby.4_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rbz.1_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rca.3_Frame_Shift_Ins_p.E318fs|ATF7IP_uc001rcb.3_5'Flank	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	Homo sapiens activating transcription factor 7 interacting protein (ATF7IP), mRNA.	318					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TGATTTTCTTGAAAAAAATGGA	0.317												
ATF7IP	55729	broad.mit.edu	37	12	14578360	14578360	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:14578359_14578359GA>G	uc001rbw.3	+	1	1668	c.1510_1510GA>G	c.(1510-1512)gaafs	p.E504fs	ATF7IP_uc010shs.1_Frame_Shift_Del_p.E504fs|ATF7IP_uc001rbu.3_Frame_Shift_Del_p.E504fs|ATF7IP_uc001rbv.1_Frame_Shift_Del_p.E504fs|ATF7IP_uc001rbx.3_Frame_Shift_Del_p.E504fs|ATF7IP_uc010sht.1_Frame_Shift_Del_p.E504fs|ATF7IP_uc001rby.4_Frame_Shift_Del_p.E504fs|ATF7IP_uc001rbz.1_Frame_Shift_Del_p.E504fs|ATF7IP_uc001rca.3_Frame_Shift_Del_p.E504fs|ATF7IP_uc001rcb.3_Frame_Shift_Del_p.E115fs	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	Homo sapiens activating transcription factor 7 interacting protein (ATF7IP), mRNA.	504	Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						TATTTCGGGTGAAAAAGATGA	0.353												
TROAP	10024	broad.mit.edu	37	12	49725381	49725382	+	Frame_Shift_Ins	INS	-	-	C	rs78835037		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:49725380_49725381G>GC	uc009zlh.3	+	13	2754_2755	c.2587_2588G>GC	c.(2587-2589)gccfs	p.A863fs	TROAP_uc001rtx.4_Frame_Shift_Ins_p.A773fs	NM_005480	NP_005471	Q12815	TROAP_HUMAN	Homo sapiens trophinin associated protein (tastin) (TROAP), transcript variant 1, mRNA.	0					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						TGGTTCTGCTGCCCCCCAGGGC	0.550											OREG0021792	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
LARP4	113251	broad.mit.edu	37	12	50847267	50847268	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:50847266_50847267A>AT	uc001rwp.2	+	8	1030_1031	c.828_829A>AT	c.(826-831)acatttfs	p.T276fs	LARP4_uc001rwq.2_Intron|LARP4_uc001rwt.2_Intron|LARP4_uc001rws.2_Frame_Shift_Ins_p.T275fs|LARP4_uc001rwr.2_Frame_Shift_Ins_p.T276fs|LARP4_uc021qxv.1_Frame_Shift_Ins_p.T206fs|LARP4_uc009zlr.1_Frame_Shift_Ins_p.T95fs|LARP4_uc001rwm.3_Frame_Shift_Ins_p.T276fs|LARP4_uc001rwn.3_Frame_Shift_Ins_p.T206fs	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	Homo sapiens La ribonucleoprotein domain family, member 4 (LARP4), transcript variant 1, mRNA.	276	RRM.						RNA binding|nucleotide binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						CCATCAATACATTTTTTGCTAA	0.322												
ITGA7	3679	broad.mit.edu	37	12	56094788	56094788	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:56094787_56094787TG>T	uc001shh.3	-	3	786	c.566_566CA>A	c.(565-567)caafs	p.Q189fs	ITGA7_uc001shg.3_Frame_Shift_Del_p.Q189fs|ITGA7_uc010sps.2_Frame_Shift_Del_p.Q92fs|ITGA7_uc009znx.3_Frame_Shift_Del_p.Q76fs	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	Homo sapiens integrin, alpha 7 (ITGA7), transcript variant 1, mRNA.	189					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						TTCATGGCCTTGGGGGCGTCC	0.582												
MBD6	114785	broad.mit.edu	37	12	57921401	57921401	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:57921400_57921400AC>A	uc001soj.1	+	7	2417	c.2193_2193AC>A	c.(2191-2193)agafs	p.R731fs	MBD6_uc001sok.1_Frame_Shift_Del_p.R598fs|MBD6_uc001sol.1_Non-coding_Transcript	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	Homo sapiens methyl-CpG binding domain protein 6 (MBD6), mRNA.	731	Pro-rich.					chromosome|nucleus	DNA binding|chromatin binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						ACTCAGGGAGACCCCCCCAAC	0.602												
MON2	23041	broad.mit.edu	37	12	62960172	62960172	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:62960171_62960171CA>C	uc001sre.3	+	28	4655	c.4264_4264CA>C	c.(4264-4266)caafs	p.Q1422fs	MON2_uc010ssn.2_Frame_Shift_Del_p.Q1416fs|MON2_uc009zqj.3_Frame_Shift_Del_p.Q1422fs|MON2_uc010ssl.2_Frame_Shift_Del_p.Q1350fs|MON2_uc010ssm.2_Frame_Shift_Del_p.Q1393fs|MON2_uc001srf.3_Frame_Shift_Del_p.Q1185fs|MON2_uc001srg.3_Frame_Shift_Del_p.Q291fs	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	Homo sapiens MON2 homolog (S. cerevisiae) (MON2), mRNA.	1423					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		GGATTTATACCAAAAAACAGC	0.358												
APAF1	317	broad.mit.edu	37	12	99071207	99071208	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:99071206_99071207C>CA	uc001tfz.3	+	12	2374_2375	c.1797_1798C>CA	c.(1795-1800)aacaaafs	p.N599fs	APAF1_uc001tfy.3_Frame_Shift_Ins_p.N588fs|APAF1_uc001tga.3_Frame_Shift_Ins_p.N588fs|APAF1_uc001tgb.3_Frame_Shift_Ins_p.N599fs|APAF1_uc001tgc.3_Intron|APAF1_uc009zto.3_Frame_Shift_Ins_p.N8fs	NM_181861	NP_863651	O14727	APAF_HUMAN	Homo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 3, mRNA.	599					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	Golgi apparatus|cytosol|nucleus	ATP binding|caspase activator activity|protein binding	p.N602fs*23(1)		breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TATTTAGAAACAAAAAAAACAT	0.347												
PXN	5829	broad.mit.edu	37	12	120657167	120657168	+	RNA	INS	-	-	C	rs61741284		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr12:120657166_120657167T>TC	uc001tya.3	-	0		c.754_755A>GA			PXN_uc001txu.3_5'Flank|PXN_uc001txx.3_Intron|PXN_uc001txt.3_Intron|PXN_uc001txv.3_Intron|PXN_uc001txy.3_Intron|PXN_uc001txz.3_Non-coding_Transcript			P49023	PAXI_HUMAN	Homo sapiens cDNA: FLJ23042 fis, clone LNG02323.						cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGGCCACACTTCCCCTCTCGGT	0.634												
ATP12A	479	broad.mit.edu	37	13	25255820	25255821	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:25255819_25255820G>GA	uc010aaa.3	+	1	462_463	c.129_130G>GA	c.(127-132)aagaaafs	p.K43fs	ATP12A_uc001upp.3_Frame_Shift_Ins_p.K43fs	NM_001185085	NP_001172014	P54707	AT12A_HUMAN	Homo sapiens ATPase, H+/K+ transporting, nongastric, alpha polypeptide (ATP12A), transcript variant 1, mRNA.	43					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AACTCAAAAAGAAAAATCACAA	0.525												
LMO7	4008	broad.mit.edu	37	13	76415965	76415966	+	Frame_Shift_Ins	INS	-	-	GA			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr13:76415964_76415965T>TGA	uc021rkq.1	+	23	4211_4212	c.3876_3877T>TGA	c.(3874-3879)attgagfs	p.I1292fs	LMO7_uc010thv.2_Frame_Shift_Ins_p.I1010fs|LMO7_uc001vjt.1_Frame_Shift_Ins_p.I958fs|LMO7_uc001vjv.3_Frame_Shift_Ins_p.I1059fs|LMO7_uc010thw.2_Frame_Shift_Ins_p.I936fs|LMO7_uc001vjw.1_Frame_Shift_Ins_p.I965fs	NM_005358	NP_005349	Q8WWI1	LMO7_HUMAN	Homo sapiens LIM domain 7 (LMO7), transcript variant 1, mRNA.	1344						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AGCTTGTTATTGAGAGAGAGAG	0.535												
APEX1	328	broad.mit.edu	37	14	20925577	20925578	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:20925576_20925577ACT>A	uc001vxg.3	+	4	1198_1199	c.866_867ACT>A	c.(865-867)cacfs	p.H289fs	OSGEP_uc001vxf.3_5'Flank|APEX1_uc001vxh.3_Frame_Shift_Del_p.H289fs|APEX1_uc001vxi.3_Frame_Shift_Del_p.H289fs|APEX1_uc021rnr.1_Frame_Shift_Del_p.H289fs	NM_001641	NP_001632	P27695	APEX1_HUMAN	Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1, mRNA.	289	Mitochondrial targeting sequence (MTS).				DNA demethylation|DNA recombination|base-excision repair|positive regulation of DNA repair|positive regulation of anti-apoptosis|regulation of mRNA stability|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|endoplasmic reticulum|mitochondrion|nuclear speck|nucleolus|perinuclear region of cytoplasm|ribosome	3'-5' exonuclease activity|DNA-(apurinic or apyrimidinic site) lyase activity|RNA binding|chromatin DNA binding|damaged DNA binding|metal ion binding|oxidoreductase activity|phosphodiesterase I activity|protein binding|ribonuclease H activity|site-specific endodeoxyribonuclease activity, specific for altered base|transcription coactivator activity|transcription corepressor activity|uracil DNA N-glycosylase activity			breast(2)|endometrium(1)|large_intestine(4)|ovary(2)	9	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)	Lucanthone(DB04967)	TTGTTGTCCCACTCTCTGTTAC	0.490								Other BER factors				
CPNE6	9362	broad.mit.edu	37	14	24542776	24542777	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:24542775_24542776A>AT	uc010tnv.2	+	3	547_548	c.401_402A>AT	c.(400-402)tatfs	p.Y134fs	CPNE6_uc001wlm.3_5'UTR|CPNE6_uc001wll.3_Frame_Shift_Ins_p.Y79fs|CPNE6_uc001wln.3_5'Flank	NM_006032	NP_006023	O95741	CPNE6_HUMAN	Homo sapiens copine VI (neuronal) (CPNE6), mRNA.	79					lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		GCCCTTGAGTATTTTTTTGAGG	0.594												
FANCM	57697	broad.mit.edu	37	14	45642288	45642289	+	Frame_Shift_Ins	INS	-	-	CT	rs117392855	by1000genomes	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:45642287_45642288A>ACT	uc001wwd.4	+	12	2289_2290	c.2190_2191A>ACT	c.(2188-2193)caactcfs	p.Q730fs	FANCM_uc010anf.3_Frame_Shift_Ins_p.Q704fs|FANCM_uc001wwe.4_Frame_Shift_Ins_p.Q266fs|FANCM_uc010ang.3_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Homo sapiens Fanconi anemia, complementation group M (FANCM), mRNA.	730					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|DNA binding|chromatin binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						GAATTCATCAACTCTCTCTCTC	0.347								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia			
SOS2	6655	broad.mit.edu	37	14	50605445	50605446	+	Frame_Shift_Ins	INS	-	-	T	rs139974077		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:50605444_50605445C>CT	uc001wxs.4	-	17	2941_2942	c.2843_2844G>AG	c.(2842-2844)aagfs	p.K948fs	SOS2_uc010tql.2_Frame_Shift_Ins_p.K915fs|SOS2_uc010tqm.1_Non-coding_Transcript	NM_006939	NP_008870	Q07890	SOS2_HUMAN	Homo sapiens son of sevenless homolog 2 (Drosophila) (SOS2), mRNA.	948	Ras-GEF.			K -> R (in Ref. 1; AAA35914).	apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|Rho guanyl-nucleotide exchange factor activity|protein binding	p.K948N(1)		cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CTTTCCCTTTCTTTTTTAAAAA	0.272												
NID2	22795	broad.mit.edu	37	14	52481919	52481919	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:52481918_52481918CG>C	uc001wzo.3	-	14	3338	c.3104_3104CG>G	c.(3103-3105)cggfs	p.R1035fs	NID2_uc010tqs.2_Frame_Shift_Del_p.R987fs|NID2_uc010tqt.1_Frame_Shift_Del_p.R1035fs|NID2_uc001wzp.3_Frame_Shift_Del_p.R1035fs	NM_007361	NP_031387	Q14112	NID2_HUMAN	Homo sapiens nidogen 2 (osteonidogen) (NID2), mRNA.	1035	Thyroglobulin type-1 2.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CTGGTCATCCCGGGGGGTGCC	0.627												
FUT8	2530	broad.mit.edu	37	14	66082954	66082956	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:66082953_66082955TGAG>T	uc001xin.3	+	4	2071_2073	c.344_346TGAG>T	c.(343-348)ctgagg>cTgg	p.R118del	FUT8_uc001xio.3_In_Frame_Del_p.R118del|FUT8_uc010tsp.2_5'UTR|FUT8_uc001xir.4_Non-coding_Transcript|FUT8_uc001xip.3_In_Frame_Del_p.R118del|FUT8_uc001xiq.3_5'UTR|FUT8_uc021ruy.1_5'Flank	NM_178155	NP_004471	Q9BYC5	FUT8_HUMAN	Homo sapiens fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (FUT8), transcript variant 1, mRNA.	118					L-fucose catabolic process|N-glycan processing|in utero embryonic development|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein glycosylation in Golgi	Golgi cisterna membrane|integral to membrane	SH3 domain binding|glycoprotein 6-alpha-L-fucosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		CATGAAATCCTGAGGAGGAGGAT	0.369												
FLRT2	23768	broad.mit.edu	37	14	86088949	86088949	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:86088948_86088948AC>A	uc021rxf.1	+	0	1090	c.1090_1090AC>A	c.(1090-1092)accfs	p.T364fs	FLRT2_uc001xvr.3_Frame_Shift_Del_p.T364fs|FLRT2_uc010atd.3_Frame_Shift_Del_p.T364fs	NM_013231	NP_037363	O43155	FLRT2_HUMAN	Homo sapiens fibronectin leucine rich transmembrane protein 2 (FLRT2), mRNA.	364					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TCCCACCACGACCCCCGGCCT	0.567												
YY1	7528	broad.mit.edu	37	14	100728644	100728645	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:100728643_100728644G>GA	uc001ygy.1	+	1	1162_1163	c.682_683G>GA	c.(682-684)gaafs	p.E228fs		NM_003403	NP_003394	P25490	TYY1_HUMAN	Homo sapiens YY1 transcription factor (YY1), mRNA.	228					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				TGTTTCAGATGAAAAAAAAGAT	0.327												
ADSSL1	122622	broad.mit.edu	37	14	105207522	105207523	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr14:105207521_105207522G>GC	uc001ypd.3	+	7	808_809	c.734_735G>GC	c.(733-735)ggcfs	p.G245fs	ADSSL1_uc001ype.3_Frame_Shift_Ins_p.G288fs|ADSSL1_uc001ypf.3_Non-coding_Transcript	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	Homo sapiens adenylosuccinate synthase like 1 (ADSSL1), transcript variant 2, mRNA.	245					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	GTP binding|adenylosuccinate synthase activity|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	GCACTCCACGGCCCCCCCAAGA	0.594												
HERC2	8924	broad.mit.edu	37	15	28366578	28366578	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:28366577_28366577TA>T	uc001zbj.3	-	86	13295	c.13189_splice	c.e86-1	p.E4397_splice		NM_004667	NP_004658	O95714	HERC2_HUMAN	Homo sapiens hect domain and RLD 2 (HERC2), mRNA.	4397					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGCCGCCTCCTAAAACACATC	0.438												
HERC2	8924	broad.mit.edu	37	15	28463820	28463820	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:28463819_28463819TA>T	uc001zbj.3	-	38	5952	c.5846_splice	c.e38-1	p.E1949_splice		NM_004667	NP_004658	O95714	HERC2_HUMAN	Homo sapiens hect domain and RLD 2 (HERC2), mRNA.	1949					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTTCGGCTTCTAAAAAAAATA	0.333												
RTF1	23168	broad.mit.edu	37	15	41749961	41749963	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:41749960_41749962GAGA>G	uc001zny.3	+	3	560_562	c.548_550GAGA>G	c.(547-552)ggagaa>gGaa	p.E184del		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Homo sapiens Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (RTF1), mRNA.	184	Glu-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	18		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		GATGGCTATGGAGAAGACCTCAT	0.483												
IGDCC4	57722	broad.mit.edu	37	15	65686807	65686807	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:65686806_65686806TG>T	uc002aou.1	-	8	1867	c.1657_1657CA>A	c.(1657-1659)agcfs	p.S553fs	IGDCC4_uc002aot.1_Frame_Shift_Del_p.S141fs	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	Homo sapiens immunoglobulin superfamily, DCC subclass, member 4 (IGDCC4), mRNA.	553	Fibronectin type-III 2.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						TTGCTCAGGCTGGGGGGCAGG	0.597												
MEGF11	84465	broad.mit.edu	37	15	66220800	66220800	+	Frame_Shift_Del	DEL	G	G	-	rs137866207	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:66220799_66220799CG>C	uc002apm.2	-	12	1780	c.1639_1639CG>G	c.(1639-1641)gtcfs	p.V547fs	MEGF11_uc002apl.2_Frame_Shift_Del_p.V472fs|MEGF11_uc002apn.1_Frame_Shift_Del_p.V547fs	NM_032445	NP_115821	A6BM72	MEG11_HUMAN	Homo sapiens multiple EGF-like-domains 11 (MEGF11), mRNA.	547						basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						TGGCCTGTGACGGGGTCACAT	0.542												
SPESP1	246777	broad.mit.edu	37	15	69238555	69238555	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:69238554_69238554GA>G	uc002arn.2	+	1	835	c.681_681GA>G	c.(679-681)ttgfs	p.L227fs	MIR548H4_uc021spl.1_Intron|NOX5_uc002arq.2_Intron|NOX5_uc002arp.2_Intron|NOX5_uc010bid.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	Homo sapiens sperm equatorial segment protein 1 (SPESP1), mRNA.	227					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						ATGACATTTTGAAAAAAATTT	0.393												
UACA	55075	broad.mit.edu	37	15	70961076	70961077	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:70961075_70961076A>AT	uc002asr.3	-	15	2051_2052	c.1947_1948T>AT	c.(1945-1950)aaattafs	p.K649fs	UACA_uc010uke.2_Frame_Shift_Ins_p.K540fs|UACA_uc002asq.3_Frame_Shift_Ins_p.K636fs|UACA_uc010bin.1_Frame_Shift_Ins_p.K624fs	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	Homo sapiens uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA), transcript variant 1, mRNA.	649						cytoskeleton|extracellular region		p.E650D(1)		breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						ATTTCTACTAATTTTTTTGCTT	0.351												
NEIL1	79661	broad.mit.edu	37	15	75644674	75644674	+	Frame_Shift_Del	DEL	C	C	-	rs34322656		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:75644673_75644673TC>T	uc002bae.3	+	3	974	c.821_821TC>T	c.(820-822)atcfs	p.I274fs	NEIL1_uc002bad.3_Frame_Shift_Del_p.I188fs	NM_024608	NP_078884	Q96FI4	NEIL1_HUMAN	Homo sapiens nei endonuclease VIII-like 1 (E. coli) (NEIL1), mRNA.	188					base-excision repair|negative regulation of nuclease activity|nucleotide-excision repair|response to oxidative stress	cytoplasm|nucleus	DNA-(apurinic or apyrimidinic site) lyase activity|damaged DNA binding|protein C-terminus binding|zinc ion binding	p.R274R(1)		breast(2)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)	13						AGGCTGAAGATCCCCCCCTTT	0.647								Base excision repair (BER), DNA glycosylases				
BTBD1	53339	broad.mit.edu	37	15	83725144	83725147	+	Frame_Shift_Del	DEL	AGTA	AGTA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:83725143_83725146GAGTA>G	uc002bjn.3	-	1	756_759	c.553_556TACTC>C	c.(553-558)actcagfs	p.T185fs	BTBD1_uc002bjo.3_Frame_Shift_Del_p.T185fs	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	Homo sapiens BTB (POZ) domain containing 1 (BTBD1), transcript variant 1, mRNA.	185						cytoplasmic mRNA processing body|protein complex	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	10				all cancers(203;0.000186)		TTACTTACCTGAGTAAGTAACATA	0.338												
TM6SF1	53346	broad.mit.edu	37	15	83805312	83805312	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr15:83805311_83805311CT>C	uc002bjp.3	+	9	1109	c.1000_1000CT>C	c.(1000-1002)cttfs	p.L334fs	TM6SF1_uc010bmq.3_Frame_Shift_Del_p.L303fs|TM6SF1_uc002bjq.3_3'UTR|TM6SF1_uc010bmr.3_Non-coding_Transcript|TM6SF1_uc002bjr.3_Frame_Shift_Del_p.L186fs	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	Homo sapiens transmembrane 6 superfamily member 1 (TM6SF1), transcript variant 1, mRNA.	334						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						AGCAAAAATCCTTTTTTTAGC	0.368												
CACNA1H	8912	broad.mit.edu	37	16	1260974	1260974	+	Splice_Site	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:1260973_1260973TG>T	uc002cks.3	+	21	4471	c.4223_splice	c.e21+2	p.R1408_splice	CACNA1H_uc002ckt.3_Splice_Site_p.R1408_splice|CACNA1H_uc002cku.3_Splice_Site_p.R114_splice|CACNA1H_uc010brj.3_Splice_Site_p.R114_splice|CACNA1H_uc002ckv.3_Splice_Site_p.R114_splice	NM_021098	NP_066921	O95180	CAC1H_HUMAN	Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit (CACNA1H), transcript variant 1, mRNA.	1408					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCCTCTGAGGTGGGGGGCTCC	0.697												
PPL	5493	broad.mit.edu	37	16	4935689	4935689	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:4935688_4935688GC>G	uc002cyd.1	-	21	3058	c.2968_2968GC>C	c.(2968-2970)cagfs	p.Q990fs		NM_002705	NP_002696	O60437	PEPL_HUMAN	Homo sapiens periplakin (PPL), mRNA.	990					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						ACGTACTCCTGCCCCCCGTCT	0.667												
ZC3H7A	29066	broad.mit.edu	37	16	11873222	11873222	+	Splice_Site	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:11873221_11873221TA>T	uc002dbk.3	-	3	307	c.109_splice	c.e3-1	p.V37_splice	ZC3H7A_uc002dbl.3_Splice_Site_p.V37_splice|ZC3H7A_uc002dbm.2_Splice_Site_p.V37_splice	NM_014153	NP_054872	Q8IWR0	Z3H7A_HUMAN	Homo sapiens zinc finger CCCH-type containing 7A (ZC3H7A), mRNA.	37						nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						CAAATATACCTAAAAAAAAGA	0.338												
DNAH3	55567	broad.mit.edu	37	16	21008625	21008625	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:21008624_21008624TC>T	uc010vbe.2	-	43	6582	c.6582_6582GA>A	c.(6580-6582)ggafs	p.G2194fs		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	Homo sapiens dynein, axonemal, heavy chain 3 (DNAH3), mRNA.	2194	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CATTCCTTCCTCCCCCGGGGG	0.542												
ARHGAP17	55114	broad.mit.edu	37	16	24958802	24958802	+	Splice_Site	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:24958801_24958801AC>A	uc002dnb.3	-	14	1334	c.1241_splice	c.e14+1	p.G414_splice	ARHGAP17_uc002dna.3_Splice_Site_p.G141_splice|ARHGAP17_uc002dnc.3_Splice_Site_p.G414_splice|ARHGAP17_uc010vcf.2_Splice_Site_p.G235_splice	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	Homo sapiens Rho GTPase activating protein 17 (ARHGAP17), transcript variant 1, mRNA.	414	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		AAGATGACTTACCCTTCATTT	0.403												
NETO2	81831	broad.mit.edu	37	16	47120148	47120149	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:47120147_47120148A>AT	uc002eer.2	-	7	1399_1400	c.986_987T>AT	c.(985-987)aatfs	p.N329fs	NETO2_uc002eeq.2_Intron|NETO2_uc010vgf.2_Frame_Shift_Ins_p.N322fs	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	Homo sapiens neuropilin (NRP) and tolloid (TLL)-like 2 (NETO2), transcript variant 1, mRNA.	329	LDL-receptor class A.					integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				CTTTACAATGATTTTCATCCCA	0.371										HNSCC(25;0.065)		
CNOT1	23019	broad.mit.edu	37	16	58555110	58555111	+	In_Frame_Ins	INS	-	-	TAC			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:58555109_58555110G>GTAC	uc002env.3	-	47	7322_7323	c.7029_7030C>GTAC	c.(7027-7032)gtacac>gtGTACac	p.H2344Y	CNOT1_uc002enw.3_Non-coding_Transcript|CNOT1_uc002enu.4_In_Frame_Ins_p.H2339Y|CNOT1_uc002ent.3_In_Frame_Ins_p.H282Y|CNOT1_uc010vik.2_In_Frame_Ins_p.H1301Y	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	Homo sapiens CCR4-NOT transcription complex, subunit 1 (CNOT1), transcript variant 1, mRNA.	2344					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GGGGCACAGTGTACAAATTCAT	0.401												
LRRC36	55282	broad.mit.edu	37	16	67397608	67397608	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:67397607_67397607TG>T	uc002esv.3	+	5	711	c.692_692TG>T	c.(691-693)ctgfs	p.L231fs	LRRC36_uc002esw.3_Non-coding_Transcript|LRRC36_uc010ceh.3_Frame_Shift_Del_p.L110fs|LRRC36_uc002esx.3_Frame_Shift_Del_p.L110fs|LRRC36_uc010vjk.2_Frame_Shift_Del_p.L110fs|LRRC36_uc010vjl.2_5'UTR	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	Homo sapiens leucine rich repeat containing 36 (LRRC36), transcript variant 1, mRNA.	231										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		ACCTTCCCACTGGGGACACAG	0.418												
KIAA0182	23199	broad.mit.edu	37	16	85682290	85682291	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr16:85682289_85682290A>AC	uc002fix.3	+	2	432_433	c.358_359A>AC	c.(358-360)accfs	p.T120fs	KIAA0182_uc002fiw.3_Frame_Shift_Ins_p.T16fs|KIAA0182_uc002fiy.3_Frame_Shift_Ins_p.T47fs	NM_014615	NP_055430	Q14687	GSE1_HUMAN	Homo sapiens KIAA0182 (KIAA0182), transcript variant 1, mRNA.	120							protein binding	p.V123fs*2(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	35						CGTGCCCAGCACCCCCCCCGTG	0.688												
PAFAH1B1	5048	broad.mit.edu	37	17	2570437	2570437	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:2570436_2570436AT>A	uc002fuw.4	+	4	911	c.343_343AT>A	c.(343-345)attfs	p.I115fs	PAFAH1B1_uc010ckb.2_Non-coding_Transcript	NM_000430	NP_000421	P43034	LIS1_HUMAN	Homo sapiens platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) (PAFAH1B1), mRNA.	115	Interaction with dynein and dynactin.				G2/M transition of mitotic cell cycle|acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|skin(1)	11						CACTCGAGTCATTTTCCATCC	0.458												
ALOX15	246	broad.mit.edu	37	17	4539247	4539247	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:4539246_4539246TG>T	uc002fyh.3	-	7	994	c.969_969CA>A	c.(967-969)acafs	p.T323fs	ALOX15_uc010vsd.2_Frame_Shift_Del_p.T284fs|ALOX15_uc010vse.2_Frame_Shift_Del_p.T345fs	NM_001140	NP_001131	P16050	LOX15_HUMAN	Homo sapiens arachidonate 15-lipoxygenase (ALOX15), mRNA.	323	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GTGGGGATCCTGTGCGGGGCA	0.617												
ELAC2	60528	broad.mit.edu	37	17	12919107	12919108	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:12919106_12919107TAC>T	uc002gnz.4	-	3	527_528	c.410_411GTA>A	c.(409-411)gtafs	p.V137fs	ELAC2_uc010vvo.2_5'Flank|ELAC2_uc010vvp.2_Frame_Shift_Del_p.V118fs|ELAC2_uc010vvq.2_Frame_Shift_Del_p.V137fs|ELAC2_uc010vvr.2_Frame_Shift_Del_p.V137fs	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	Homo sapiens elaC homolog 2 (E. coli) (ELAC2), transcript variant 1, mRNA.	137					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						GTCCAGAAAGTACACACTTTGG	0.371												
KRTAP4-1	85285	broad.mit.edu	37	17	39340921	39340921	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:39340920_39340920TG>T	uc002hwe.4	-	0	228	c.187_187CA>A	c.(187-189)agcfs	p.S63fs	KRTAP4-1_uc010cxm.1_Non-coding_Transcript	NM_033060	NP_149049	Q9BYQ7	KRA41_HUMAN	Homo sapiens keratin associated protein 4-1 (KRTAP4-1), mRNA.	63	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].					keratin filament				kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			TGGCAGCAGCTGGGGCGACAG	0.647												
RNF43	54894	broad.mit.edu	37	17	56435161	56435161	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:56435160_56435160AC>A	uc002iwf.3	-	7	3933	c.1977_1977GT>T	c.(1975-1977)ggtfs	p.G659fs	RNF43_uc010wnv.2_Frame_Shift_Del_p.G618fs|RNF43_uc002iwh.4_Frame_Shift_Del_p.G659fs|RNF43_uc002iwg.4_Frame_Shift_Del_p.G659fs|RNF43_uc010dcw.3_Frame_Shift_Del_p.G532fs	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	Homo sapiens ring finger protein 43 (RNF43), mRNA.	659	Pro-rich.					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding	p.G659fs*41(1)		NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCTCGGAGGGACCCCCCCGCC	0.597												
RNF43	54894	broad.mit.edu	37	17	56435355	56435357	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:56435354_56435356CAGG>C	uc002iwf.3	-	7	3737_3739	c.1781_1783CCTG>G	c.(1780-1785)cctgat>cGat	p.594_595PD>R	RNF43_uc010wnv.2_In_Frame_Del_p.553_554PD>R|RNF43_uc002iwh.4_In_Frame_Del_p.594_595PD>R|RNF43_uc002iwg.4_In_Frame_Del_p.594_595PD>R|RNF43_uc010dcw.3_In_Frame_Del_p.467_468PD>R	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	Homo sapiens ring finger protein 43 (RNF43), mRNA.	594	Pro-rich.					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACTTGCTGATCAGGAGAAGGTGG	0.650												
CD300C	10871	broad.mit.edu	37	17	72541038	72541038	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:72541037_72541037TC>T	uc002jky.1	-	1	472	c.111_111GA>A	c.(109-111)ggafs	p.G37fs		NM_006678	NP_006669	Q08708	CLM6_HUMAN	Homo sapiens CD300c molecule (CD300C), mRNA.	37	Ig-like V-type.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						CACTCAGGGATCCCCCCACGG	0.542												
SLC16A5	9121	broad.mit.edu	37	17	73094188	73094188	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:73094187_73094187TG>T	uc002jmr.3	+	3	626	c.254_254TG>T	c.(253-255)ctgfs	p.L85fs	SLC16A5_uc002jmt.3_Frame_Shift_Del_p.L85fs|SLC16A5_uc002jmu.3_Frame_Shift_Del_p.L85fs|SLC16A5_uc010wrt.2_Frame_Shift_Del_p.L125fs	NM_004695	NP_004686	O15375	MOT6_HUMAN	Homo sapiens solute carrier family 16, member 5 (monocarboxylic acid transporter 6) (SLC16A5), mRNA.	85					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	ACCGTGATGCTGGGGGGCGTG	0.617												
HEXDC	284004	broad.mit.edu	37	17	80400208	80400209	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr17:80400207_80400208G>GC	uc002kev.4	+	11	1913_1914	c.1497_1498G>GC	c.(1495-1500)ctgcccfs	p.L499fs	HEXDC_uc002kew.3_Frame_Shift_Ins_p.A470fs|HEXDC_uc010wvm.2_Non-coding_Transcript	NM_173620	NP_775891	Q8WVB3	HEXDC_HUMAN	Homo sapiens hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing (HEXDC), mRNA.	0					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CGAGGTGTCTGCCCCCCCGCTG	0.688												
CHST9	83539	broad.mit.edu	37	18	24524316	24524317	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:24524315_24524316A>AT	uc002kwd.3	-	3	446_447	c.217_218T>AT	c.(217-219)atcfs	p.I73fs	CHST9-AS1_uc010xbm.2_Intron|CHST9_uc002kwe.3_Frame_Shift_Ins_p.I73fs|CHST9_uc021uij.1_Intron	NM_001243848	NP_001230777	Q7L1S5	CHST9_HUMAN	Homo sapiens carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 (CHST9), transcript variant 2, mRNA.	73					carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|extracellular region|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|skin(3)	28	all_lung(6;0.0145)|Ovarian(20;0.124)					ATGTTCCTGGATTTTTTCTGTA	0.302												
FHOD3	80206	broad.mit.edu	37	18	34205516	34205516	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:34205515_34205515AC>A	uc021uiv.1	+	9	1096	c.999_999AC>A	c.(997-999)ccafs	p.P333fs	FHOD3_uc002kzr.1_Frame_Shift_Del_p.P333fs|FHOD3_uc002kzs.1_Frame_Shift_Del_p.P333fs|FHOD3_uc002kzt.1_Frame_Shift_Del_p.P333fs|FHOD3_uc002kzu.1_Frame_Shift_Del_p.P158fs|FHOD3_uc010dmz.1_Frame_Shift_Del_p.P86fs	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	Homo sapiens formin homology 2 domain containing 3 (FHOD3), mRNA.	333	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CCACGGAGCCACCCCCCAGTG	0.677												
ZBTB7C	201501	broad.mit.edu	37	18	45566519	45566520	+	Frame_Shift_Ins	INS	-	-	C	rs113275715		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:45566518_45566519G>GC	uc010dnv.3	-	2	1462_1463	c.1026_1027C>GC	c.(1024-1029)gggcctfs	p.G342fs	ZBTB7C_uc002ldb.3_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010dnu.3_Frame_Shift_Ins_p.G329fs|ZBTB7C_uc010dnw.3_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010dnx.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010dny.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010dnz.1_Frame_Shift_Ins_p.G342fs|ZBTB7C_uc010doi.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010doj.1_Frame_Shift_Ins_p.G329fs|ZBTB7C_uc010dok.1_Frame_Shift_Ins_p.G369fs|ZBTB7C_uc010dol.1_Frame_Shift_Ins_p.G329fs|ZBTB7C_uc010doa.1_Frame_Shift_Ins_p.G342fs|ZBTB7C_uc010dob.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010doc.1_Frame_Shift_Ins_p.G329fs|ZBTB7C_uc010dod.1_Frame_Shift_Ins_p.G342fs|ZBTB7C_uc010doe.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010dof.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010dog.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010doh.1_Frame_Shift_Ins_p.G329fs|ZBTB7C_uc010dom.1_Frame_Shift_Ins_p.G329fs|ZBTB7C_uc010don.1_Frame_Shift_Ins_p.G328fs|ZBTB7C_uc010dop.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010doq.1_Frame_Shift_Ins_p.G329fs|ZBTB7C_uc010dor.1_Frame_Shift_Ins_p.G342fs|ZBTB7C_uc010dos.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010dot.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010doo.1_Frame_Shift_Ins_p.G320fs|ZBTB7C_uc010dou.1_Frame_Shift_Ins_p.G329fs	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	Homo sapiens zinc finger and BTB domain containing 7C (ZBTB7C), mRNA.	320						intracellular	nucleic acid binding|zinc ion binding	p.L343L(1)		endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GGTCCCAGAGGCCCCCCCGGCA	0.624												
ALPK2	115701	broad.mit.edu	37	18	56278998	56278998	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:56278997_56278997CG>C	uc002lhj.4	-	1	247	c.33_33CG>G	c.(31-33)ccgfs	p.P11fs		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	Homo sapiens alpha-kinase 2 (ALPK2), mRNA.	11	Ig-like 1.						ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						AAAAACACAGCGGGGGCCTCT	0.453												
CDH19	28513	broad.mit.edu	37	18	64172527	64172527	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr18:64172526_64172526CA>C	uc002lkc.1	-	11	1980	c.1842_1842TG>G	c.(1840-1842)ttgfs	p.L614fs	CDH19_uc010dql.1_Non-coding_Transcript|CDH19_uc010xey.1_Frame_Shift_Del_p.*491fs	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	Homo sapiens cadherin 19, type 2 (CDH19), mRNA.	614					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				AACCCAAAGTCAAAAAAATAA	0.323												
DOT1L	84444	broad.mit.edu	37	19	2191141	2191141	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:2191140_2191140TC>T	uc002lvb.4	+	4	430	c.394_394TC>T	c.(394-396)tccfs	p.S132fs		NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	Homo sapiens DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L), mRNA.	132						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGAGCCCTTCTCCCCCGAGGT	0.602												
ZNF426	79088	broad.mit.edu	37	19	9639888	9639888	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:9639887_9639887CT>C	uc002mlq.3	-	7	1098	c.834_834AG>G	c.(832-834)aagfs	p.K278fs	ZNF426_uc010dws.3_Frame_Shift_Del_p.K240fs	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	Homo sapiens zinc finger protein 426 (ZNF426), mRNA.	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						ATTTGTAGGGCTTTTTTGCAT	0.423												
FBXL12	54850	broad.mit.edu	37	19	9922291	9922291	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:9922290_9922290TG>T	uc002mme.3	-	2	505	c.263_263CA>A	c.(262-264)cagfs	p.Q88fs	FBXL12_uc002mmd.3_Frame_Shift_Del_p.Q35fs|FBXL12_uc002mmf.3_Frame_Shift_Del_p.Q35fs|FBXL12_uc002mmg.3_Frame_Shift_Del_p.Q35fs	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	Homo sapiens F-box and leucine-rich repeat protein 12 (FBXL12), mRNA.	88							protein binding	p.Q88fs*7(1)		endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(2)	10						AGGGGACAACTGGGGGGCCTG	0.632												
NCAN	1463	broad.mit.edu	37	19	19338309	19338310	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:19338308_19338309T>TC	uc002nlz.3	+	7	1978_1979	c.1879_1880T>TC	c.(1879-1881)tccfs	p.S627fs	NCAN_uc010ecc.1_Frame_Shift_Ins_p.S191fs	NM_004386	NP_004377	O14594	NCAN_HUMAN	Homo sapiens neurocan (NCAN), mRNA.	627					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			TGTGGCCACCTCCCCAGATCTC	0.629												
PSMC4	5704	broad.mit.edu	37	19	40480654	40480655	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:40480653_40480654T>TC	uc002omq.3	+	5	628_629	c.591_592T>TC	c.(589-594)gatcccfs	p.D197fs	PSMC4_uc002omr.3_Frame_Shift_Ins_p.D166fs	NM_006503	NP_006494	P43686	PRS6B_HUMAN	Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 4 (PSMC4), transcript variant 1, mRNA.	197					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCGGCATCGATCCCCCCCGAGG	0.614												
SHKBP1	92799	broad.mit.edu	37	19	41083179	41083181	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:41083178_41083180CCTT>C	uc002oob.3	+	1	177_179	c.128_130CCTT>C	c.(127-132)tccttc>tCtc	p.F45del	SHKBP1_uc002ooc.3_In_Frame_Del_p.F45del|SHKBP1_uc010xvl.1_5'UTR|SHKBP1_uc002ooe.3_5'UTR|SHKBP1_uc010xvm.2_5'Flank|SHKBP1_uc010xvn.2_5'Flank	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	Homo sapiens SH3KBP1 binding protein 1 (SHKBP1), mRNA.	45	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ATCCCAGACTCCTTCTTCTCCAG	0.611												
BAX	581	broad.mit.edu	37	19	49458971	49458972	+	Frame_Shift_Ins	INS	-	-	G	rs141306106	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:49458970_49458971T>TG	uc002plk.3	+	2	182_183	c.113_114T>TG	c.(112-114)atgfs	p.M38fs	BAX_uc002plf.1_Frame_Shift_Ins_p.M38fs|BAX_uc002plg.1_Frame_Shift_Ins_p.M1fs|BAX_uc002plh.1_Intron|BAX_uc010xzx.2_Non-coding_Transcript|BAX_uc002plj.3_Frame_Shift_Ins_p.M38fs|BAX_uc002pll.3_Intron|BAX_uc002plm.3_Intron	NM_138761	NP_620116	Q07812	BAX_HUMAN	Homo sapiens BCL2-associated X protein (BAX), transcript variant alpha, mRNA.	38					B cell apoptosis|DNA fragmentation involved in apoptotic nuclear change|activation of caspase activity by cytochrome c|activation of pro-apoptotic gene products|cleavage of lamin|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|induction of retinal programmed cell death|mitochondrial fragmentation involved in apoptosis|mitochondrial fusion|negative regulation of protein binding|negative regulation of survival gene product expression|nuclear fragmentation involved in apoptotic nuclear change|positive regulation of neuron apoptosis|protein homooligomerization|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria|release of matrix enzymes from mitochondria|response to toxin|transformed cell apoptosis	cytosol|endoplasmic reticulum membrane|mitochondrial outer membrane|mitochondrial permeability transition pore complex|nucleus	BH3 domain binding|channel activity|lipid binding|protein heterodimerization activity|protein homodimerization activity	p.E41fs*19(1)|p.R37*(1)		central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(4)	17		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000159)|all cancers(93;0.00047)|GBM - Glioblastoma multiforme(486;0.018)|Epithelial(262;0.0279)		GCAGGGCGAATGGGGGGGGAGG	0.594												
ZNF324	25799	broad.mit.edu	37	19	58980596	58980596	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr19:58980595_58980595TG>T	uc002qsw.2	+	1	188	c.43_43TG>T	c.(43-45)tggfs	p.W15fs		NM_014347	NP_055162	O75467	Z324A_HUMAN	Homo sapiens zinc finger protein 324 (ZNF324), mRNA.	15	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CCAGGAGGAGTGGGGGCTCCT	0.572												
C20orf194	25943	broad.mit.edu	37	20	3321163	3321164	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:3321162_3321163C>CAA	uc002wii.2	-	9	1020_1021	c.969_970G>TTG	c.(967-972)tttgccfs	p.F323fs	C20orf194_uc002wij.3_Frame_Shift_Ins_p.F62fs|C20orf194_uc002wik.2_5'UTR|C20orf194_uc010gay.1_Non-coding_Transcript	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	Homo sapiens chromosome 20 open reading frame 194 (C20orf194), mRNA.	323										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						ATGTGCTTGGCAAAGCTCCCGC	0.505												
OTOR	56914	broad.mit.edu	37	20	16729577	16729578	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:16729576_16729577T>TA	uc002wpj.3	+	1	224_225	c.180_181T>TA	c.(178-183)gttaaafs	p.V60fs		NM_020157	NP_064542	Q9NRC9	OTOR_HUMAN	Homo sapiens otoraplin (OTOR), mRNA.	60	SH3.				sensory perception of sound	extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|liver(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10						TCATTAACGTTAAAAAAGGGCA	0.356												
RALGAPB	57148	broad.mit.edu	37	20	37146233	37146233	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr20:37146232_37146232AC>A	uc002xiw.3	+	7	1392	c.1135_1135AC>A	c.(1135-1137)accfs	p.T379fs	RALGAPB_uc010zvz.1_Frame_Shift_Del_p.T379fs|RALGAPB_uc002xix.3_Frame_Shift_Del_p.T379fs|RALGAPB_uc002xiy.1_Frame_Shift_Del_p.T379fs|RALGAPB_uc002xiz.3_Frame_Shift_Del_p.T157fs|RALGAPB_uc002xja.1_Frame_Shift_Del_p.T106fs	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Homo sapiens Ral GTPase activating protein, beta subunit (non-catalytic) (RALGAPB), mRNA.	379					activation of Ral GTPase activity	intracellular	Ral GTPase activator activity|protein heterodimerization activity	p.H382fs*2(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGTCAGTACCACCCCCCCACA	0.443												
MRAP	56246	broad.mit.edu	37	21	33684272	33684272	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:33684271_33684271TC>T	uc002ypj.3	+	4	670	c.483_483TC>T	c.(481-483)cctfs	p.P161fs	MRAP_uc002ypk.3_Intron|URB1_uc002ypn.2_3'UTR|MRAP_uc011ado.2_Frame_Shift_Del_p.P102fs|MRAP_uc002ypl.3_Frame_Shift_Del_p.P161fs	NM_178817	NP_848932	Q8TCY5	MRAP_HUMAN	Homo sapiens melanocortin 2 receptor accessory protein (MRAP), transcript variant 1, mRNA.	161					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding	p.E160E(1)		endometrium(1)|large_intestine(2)|lung(3)	6						CCAGCGAGCCTCCCCCTGGAG	0.587												
RCAN1	1827	broad.mit.edu	37	21	35890429	35890430	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:35890428_35890429A>AT	uc002yue.3	-	3	784_785	c.712_713T>AT	c.(712-714)attfs	p.I238fs	RCAN1_uc002yuc.3_Frame_Shift_Ins_p.I157fs|RCAN1_uc002yud.3_Frame_Shift_Ins_p.I103fs|RCAN1_uc002yub.3_Frame_Shift_Ins_p.I183fs	NM_004414	NP_004405	P53805	RCAN1_HUMAN	Homo sapiens regulator of calcineurin 1 (RCAN1), transcript variant 1, mRNA.	238					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(1)|lung(2)	5						GGTCTGGATAATTTTTGGCTTA	0.510												
TTC3	7267	broad.mit.edu	37	21	38555143	38555144	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:38555142_38555143GAA>G	uc002yvz.3	+	35	4789_4790	c.4684_4685GAA>G	c.(4684-4686)gaafs	p.E1562fs	TTC3_uc002ywa.3_Frame_Shift_Del_p.E1562fs|TTC3_uc002ywb.3_Frame_Shift_Del_p.E1562fs|TTC3_uc010gnf.3_Frame_Shift_Del_p.E1327fs|TTC3_uc002ywc.3_Frame_Shift_Del_p.E1252fs|TTC3_uc002ywd.1_Frame_Shift_Del_p.E626fs	NM_001001894	NP_003307	P53804	TTC3_HUMAN	Homo sapiens tetratricopeptide repeat domain 3 (TTC3), transcript variant 2, mRNA.	1562					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				ATGGCAACAGGAAAAAAAAGAA	0.287												
RIPK4	54101	broad.mit.edu	37	21	43165935	43165936	+	Frame_Shift_Ins	INS	-	-	G	rs144324321		TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:43165934_43165935C>CG	uc002yzn.1	-	5	968_969	c.920_921G>CG	c.(919-921)ccgfs	p.P307fs		NM_020639	NP_065690	Q96T11	Q96T11_HUMAN	Homo sapiens receptor-interacting serine-threonine kinase 4 (RIPK4), mRNA.	307						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TCCTGGGCTCCGGGGGGCTTTT	0.535												
MCM3AP	8888	broad.mit.edu	37	21	47704673	47704673	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr21:47704672_47704672TA>T	uc002zir.1	-	0	565	c.529_529TA>A	c.(529-531)acafs	p.T177fs	YBEY_uc002zit.1_5'Flank|YBEY_uc002ziu.1_5'Flank|YBEY_uc010gqh.3_5'Flank|YBEY_uc002ziv.3_5'Flank|YBEY_uc002ziw.3_5'Flank|YBEY_uc002zix.3_5'Flank|YBEY_uc002ziy.3_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	Homo sapiens minichromosome maintenance complex component 3 associated protein (MCM3AP), mRNA.	177					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					TGGGAAAATGTAAAAAACCCA	0.433												
SERPIND1	3053	broad.mit.edu	37	22	21134078	21134079	+	Frame_Shift_Ins	INS	-	-	CCTGC			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:21134077_21134078T>TCCTGC	uc002ztc.2	+	0	564_565	c.561_562T>TCCTGC	c.(559-564)tctactfs	p.S187fs	PI4KA_uc002zsz.4_Intron|SERPIND1_uc002ztb.1_Frame_Shift_Ins_p.S159fs	NM_000185	NP_000176	P05546	HEP2_HUMAN	Homo sapiens serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (SERPIND1), mRNA.	159					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TTGGCATTTCTACTGCGATGGG	0.441												
CARD10	29775	broad.mit.edu	37	22	37893150	37893150	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:37893149_37893149TG>T	uc003asx.1	-	11	1841	c.1824_1824CA>A	c.(1822-1824)ccafs	p.P608fs	CARD10_uc003ast.1_Non-coding_Transcript|CARD10_uc003asv.1_5'Flank|CARD10_uc011ank.1_5'Flank|CARD10_uc003asw.1_Frame_Shift_Del_p.P322fs|CARD10_uc003asy.1_Frame_Shift_Del_p.P608fs	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	Homo sapiens caspase recruitment domain family, member 10 (CARD10), mRNA.	608					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	17	Melanoma(58;0.0574)					CTGGGCCCCCTGGGGGGCTCC	0.587												
ZBED4	9889	broad.mit.edu	37	22	50277679	50277680	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:50277678_50277679A>AT	uc003bix.2	+	1	838_839	c.368_369A>AT	c.(367-369)catfs	p.H123fs	ZBED4_uc021wrx.1_Frame_Shift_Ins_p.H123fs	NM_014838	NP_055653	O75132	ZBED4_HUMAN	Homo sapiens zinc finger, BED-type containing 4 (ZBED4), mRNA.	123						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCCTGGAAGCATTTTTTTATCT	0.510												
MOV10L1	54456	broad.mit.edu	37	22	50559005	50559005	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chr22:50559004_50559004CA>C	uc003bjj.3	+	9	1611	c.1528_1528CA>C	c.(1528-1530)caafs	p.Q510fs	MOV10L1_uc003bjk.4_Frame_Shift_Del_p.Q510fs|MOV10L1_uc011arp.2_Frame_Shift_Del_p.Q490fs|MOV10L1_uc011arq.1_Frame_Shift_Del_p.Q271fs|MOV10L1_uc010hao.1_Intron	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	Homo sapiens Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) (MOV10L1), transcript variant 1, mRNA.	510					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|RNA binding|magnesium ion binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		ATGTGTGGAACAAAAAATTGA	0.393												
PPP2R3B	28227	broad.mit.edu	37	X	302052	302052	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:302051_302051GT>G	uc004cpg.3	-	8	1430	c.1166_1166AC>C	c.(1165-1167)acafs	p.T389fs	PPP2R3B_uc004cpf.3_5'UTR	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	Homo sapiens protein phosphatase 2, regulatory subunit B'', beta (PPP2R3B), mRNA.	389	EF-hand.				cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			endometrium(5)|lung(5)|skin(1)	11		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCTGGTCGGTGTTTTTTTGTC	0.562												
GPR64	10149	broad.mit.edu	37	X	19046359	19046360	+	Splice_Site	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:19046358_19046359T>TA	uc004cyx.3	-	10	601	c.359_splice	c.e10-1	p.A120_splice	GPR64_uc004cze.3_Splice_Site_p.A90_splice|GPR64_uc004cza.3_Splice_Site_p.A98_splice|GPR64_uc004czf.3_Splice_Site_p.A82_splice|GPR64_uc004cyy.3_Splice_Site_p.A117_splice|GPR64_uc004czc.3_Splice_Site_p.A104_splice|GPR64_uc004cyz.3_Splice_Site_p.A106_splice|GPR64_uc004czb.3_Splice_Site_p.A120_splice|GPR64_uc004czd.3_Splice_Site_p.A96_splice|GPR64_uc004cyw.3_Splice_Site_p.A104_splice|GPR64_uc010nfj.3_Splice_Site_p.A90_splice	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	Homo sapiens G protein-coupled receptor 64 (GPR64), transcript variant 1, mRNA.	120					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					TAAAAAATGCTAAAAATAAATT	0.262												
CXorf22	170063	broad.mit.edu	37	X	35993957	35993959	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:35993956_35993958ATTG>A	uc004ddj.3	+	14	2705_2707	c.2639_2641ATTG>A	c.(2638-2643)aattgt>aAgt	p.880_881NC>K	CXorf22_uc010ngv.3_Non-coding_Transcript	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	Homo sapiens chromosome X open reading frame 22 (CXorf22), mRNA.	880										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AATCGTCAGAATTGTTGTGCTCA	0.384												
HS6ST2	90161	broad.mit.edu	37	X	131762582	131762583	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:131762581_131762582C>CA	uc011mvd.1	-	5	2023_2024	c.1607_1608G>TG	c.(1606-1608)ttgfs	p.L536fs	HS6ST2_uc011mvb.1_Frame_Shift_Ins_p.L390fs|HS6ST2_uc011mvc.1_Frame_Shift_Ins_p.L350fs|HS6ST2_uc011mve.1_Frame_Shift_Ins_p.L496fs|HS6ST2_uc011mva.1_Frame_Shift_Ins_p.L222fs	NM_001077188	NP_001070656	Q96MM7	H6ST2_HUMAN	Homo sapiens heparan sulfate 6-O-sulfotransferase 2 (HS6ST2), transcript variant L, mRNA.	496						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					GATACCTCTGCAAAAAAAGGTC	0.450												
AFF2	2334	broad.mit.edu	37	X	148039963	148039963	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:148039962_148039962AC>A	uc004fcp.3	+	11	3143	c.2664_2664AC>A	c.(2662-2664)ccafs	p.P888fs	AFF2_uc004fcq.3_Frame_Shift_Del_p.P878fs|AFF2_uc004fcr.3_Frame_Shift_Del_p.P849fs|AFF2_uc011mxb.2_Frame_Shift_Del_p.P853fs|AFF2_uc004fcs.3_Frame_Shift_Del_p.P855fs|AFF2_uc011mxc.2_Frame_Shift_Del_p.P529fs	NM_002025	NP_002016	P51816	AFF2_HUMAN	Homo sapiens AF4/FMR2 family, member 2 (AFF2), transcript variant 1, mRNA.	888					RNA splicing|brain development|mRNA processing|regulation of RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CACCAGCCCCACCCCACAAGC	0.512												
MAGEA8	4107	broad.mit.edu	37	X	149013702	149013702	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:149013701_149013701GC>G	uc022cgq.1	+	0	655	c.655_655GC>G	c.(655-657)gccfs	p.A219fs	MAGEA8_uc022cgo.1_Frame_Shift_Del_p.A219fs|MAGEA8_uc004fdw.2_Frame_Shift_Del_p.A219fs|MAGEA8_uc022cgp.1_Frame_Shift_Del_p.A219fs	NM_005364	NP_005355	P43361	MAGA8_HUMAN	Homo sapiens melanoma antigen family A, 8 (MAGEA8), transcript variant 3, mRNA.	219	MAGE.							p.R218H(1)		NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;6.56e-05)					GGGCAGCCGCGCCCCGGAGGA	0.577												
MAGEA8	4107	broad.mit.edu	37	X	149013888	149013889	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:149013887_149013888C>CT	uc022cgq.1	+	0	841_842	c.841_842C>CT	c.(841-843)cttfs	p.L281fs	MAGEA8_uc022cgo.1_Frame_Shift_Ins_p.L281fs|MAGEA8_uc004fdw.2_Frame_Shift_Ins_p.L281fs|MAGEA8_uc022cgp.1_Frame_Shift_Ins_p.L281fs	NM_005364	NP_005355	P43361	MAGA8_HUMAN	Homo sapiens melanoma antigen family A, 8 (MAGEA8), transcript variant 3, mRNA.	281	MAGE.									NS(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAAGGGCCCTTGCTGAAACC	0.579												
PRRG3	79057	broad.mit.edu	37	X	150869297	150869298	+	Frame_Shift_Ins	INS	-	-	G	rs139807152	byFrequency	TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:150869296_150869297C>CG	uc022cgt.1	+	3	536_537	c.487_488C>CG	c.(487-489)cggfs	p.R163fs	PRRG3_uc004few.2_Frame_Shift_Ins_p.R163fs	NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	Homo sapiens proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (PRRG3), transcript variant 1, mRNA.	163						extracellular region|integral to membrane	calcium ion binding	p.R163P(2)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					GGGGCCCAGTCGGGGGGGCAGG	0.673												
CNGA2	1260	broad.mit.edu	37	X	150912002	150912002	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:150912001_150912001AC>A	uc004fey.1	+	6	1250	c.1026_1026AC>A	c.(1024-1026)ccafs	p.P342fs		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	Homo sapiens cyclic nucleotide gated channel alpha 2 (CNGA2), mRNA.	342					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGACACCACCCCCTGTAA	0.493												
GABRQ	55879	broad.mit.edu	37	X	151821591	151821591	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:151821590_151821590GC>G	uc004ffp.1	+	8	1765	c.1745_1745GC>G	c.(1744-1746)tgcfs	p.C582fs		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) receptor, theta (GABRQ), mRNA.	582						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	GABA-A receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					GAGGATAGTTGCCCCCCAAGC	0.517												
F8	2157	broad.mit.edu	37	X	154158195	154158195	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BR-4292-01A-01D-1126-08	TCGA-BR-4292-11A-01D-1126-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7fafe9d-132f-4939-b049-9cc998ec1bc6	126ae43a-7a3b-4037-a5dc-9ad55b2f24bc	g.chrX:154158194_154158194CT>C	uc004fmt.3	-	13	4042	c.3871_3871AG>G	c.(3871-3873)gggfs	p.G1291fs		NM_000132	NP_000123	P00451	FA8_HUMAN	Homo sapiens coagulation factor VIII, procoagulant component (F8), transcript variant 1, mRNA.	1291	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCTTCCTCCCCTTTTTTTGAG	0.378