Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MBD3	53615	broad.mit.edu	37	19	1578380	1578380	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:1578380C>T	ENST00000590550.2	-	5	1040	c.667G>A	c.(667-669)Gag>Aag	p.E223K	MBD3_ENST00000434436.3_Missense_Mutation_p.E279K|MBD3_ENST00000156825.1_Missense_Mutation_p.E279K|MBD3_ENST00000592012.1_Missense_Mutation_p.E247K			O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	279					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		GGctcctcctcctcctcctcc	0.716000													20	47					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540211	133540211	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:133540211G>T	ENST00000409261.1	-	14	4546	c.4173C>A	c.(4171-4173)ttC>ttA	p.F1391L	NCKAP5_ENST00000317721.6_Missense_Mutation_p.F1391L|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1391							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTCCCTGGGTGAAGGCCTGCT	0.602000													20	62					8.34094e-07	8.41198e-07	1	1	0
TUBGCP2	10844	broad.mit.edu	37	10	135095785	135095785	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:135095785G>A	ENST00000368563.2	-	16	2707	c.2351C>T	c.(2350-2352)aCc>aTc	p.T784I	TUBGCP2_ENST00000543663.1_Missense_Mutation_p.T812I|TUBGCP2_ENST00000252936.3_Missense_Mutation_p.T784I|TUBGCP2_ENST00000417178.2_Missense_Mutation_p.T654I|TUBGCP2_ENST00000368562.1_Missense_Mutation_p.T377I	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	784					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CCCCAGGACGGTGCTGTGCTC	0.622000													14	22					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118498844	118498844	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:118498844C>T	ENST00000361417.2	+	7	1716	c.1305C>T	c.(1303-1305)acC>acT	p.T435T	PHLDB1_ENST00000356063.5_Silent_p.T435T	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	435										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		GGTTAGCCACCCGTACCCTGC	0.642000													88	181					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	95034772	95034772	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:95034772G>A	ENST00000377047.4	+	7	1872	c.1257G>A	c.(1255-1257)gaG>gaA	p.E419E		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	419						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CGTCCAACGAGGAGGAATGCT	0.542000													31	97					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160679691	160679691	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:160679691G>A	ENST00000366952.1	-	3	1517	c.36C>T	c.(34-36)ttC>ttT	p.F12F	SLC22A2_ENST00000491092.1_5'UTR|SLC22A2_ENST00000366953.3_Silent_p.F33F			O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	33					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		AGATGGGCGCGAAGGTAGCCG	0.612000													41	59					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49724043	49724043	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:49724043G>A	ENST00000303221.5	-	2	346	c.131C>T	c.(130-132)cCa>cTa	p.P44L	EMB_ENST00000508934.1_Missense_Mutation_p.P44L|EMB_ENST00000514111.1_5'UTR|EMB_ENST00000506190.1_5'UTR	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	44						integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TCTGAGAGGTGGACTTGTAAA	0.323000													24	64					0	0	1	0	0
ZNF655	79027	broad.mit.edu	37	7	99170003	99170003	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:99170003A>C	ENST00000424881.1	+	4	597	c.377A>C	c.(376-378)aAg>aCg	p.K126T	ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000252713.4_Missense_Mutation_p.K91T|ZNF655_ENST00000493277.1_Missense_Mutation_p.K126T|ZNF655_ENST00000394163.2_Missense_Mutation_p.K91T	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	91					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GAAGTGTATAAGTCTGAGGAC	0.393000													23	65					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35993386	35993386	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:35993386C>T	ENST00000297866.5	+	14	2443	c.2377C>T	c.(2377-2379)Cag>Tag	p.Q793*		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	793										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AGAAGAACTTCAGAAGACCAA	0.343000													48	36					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156914894	156914894	+	Missense_Mutation	SNP	G	G	A	rs140673049		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:156914894G>A	ENST00000368194.3	-	30	3947	c.2908C>T	c.(2908-2910)Cgc>Tgc	p.R970C	ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000315174.8_Missense_Mutation_p.R346C|ARHGEF11_ENST00000361409.2_Missense_Mutation_p.R930C	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	930	PH.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AAACGGTGGCGGTTCTCTGTT	0.597000													64	273					0	0	1	0	0
NTF3	4908	broad.mit.edu	37	12	5603504	5603504	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:5603504G>A	ENST00000423158.3	+	2	375	c.163G>A	c.(163-165)Gat>Aat	p.D55N	NTF3_ENST00000535299.1_Intron|NTF3_ENST00000331010.6_Missense_Mutation_p.D42N	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	42					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						GATCCAGGCAGATATTTTGAA	0.493000													37	99					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179465714	179465714	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179465714C>T	ENST00000589042.1	-	288	56141	c.55917G>A	c.(55915-55917)gtG>gtA	p.V18639V	TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.V9699V|TTN_ENST00000342992.6_Silent_p.V16071V|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Silent_p.V9766V|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.V16998V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000460472.2_Silent_p.V9574V|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16998	Fibronectin type-III 35.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAGTTCTTCCACATCACGCT	0.498000													58	189					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7949624	7949624	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:7949624C>T	ENST00000309838.2	-	1	585	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCATAGATTTCAAACAAAAAC	0.383000													24	69					0	0	1	0	0
TRIM40	135644	broad.mit.edu	37	6	30114951	30114951	+	Silent	SNP	A	A	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:30114951A>C	ENST00000396581.1	+	4	1017	c.631A>C	c.(631-633)Agg>Cgg	p.R211R	TRIM40_ENST00000376724.2_Silent_p.R211R|TRIM40_ENST00000307859.4_Silent_p.R182R			Q6P9F5	TRI40_HUMAN	tripartite motif containing 40	211						intracellular	zinc ion binding			ovary(1)	1						TGATCTGGAAAGGACGGCCAA	0.572000													54	149					0	0	1	0	0
MIR520A	574467	broad.mit.edu	37	19	54194150	54194150	+	RNA	SNP	T	T	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:54194150T>C	ENST00000384862.1	+	0	16					NR_030189.1																						GCTGTGACCCTCCAGAGGGAA	0.418000													95	240					0	0	1	0	0
GRIN3B	116444	broad.mit.edu	37	19	1005379	1005379	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:1005379C>T	ENST00000234389.3	+	3	1898	c.1879C>T	c.(1879-1881)Ctc>Ttc	p.L627F		NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	627					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity			breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CTACGCCATCCTCTTCAGACG	0.642000													77	174					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23815355	23815355	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:23815355G>A	ENST00000264867.2	-	8	1870	c.1751C>T	c.(1750-1752)tCc>tTc	p.S584F	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	584	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TCTTGACCTGGAATATGGTGA	0.438000													27	74					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522815	95522815	+	RNA	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:95522815A>G	ENST00000432432.2	-	0	212					NR_040113.1																						ATCTTCTGCAATTCGGAGTCC	0.652000													4	117					0	0	1	0	0
FAM120C	54954	broad.mit.edu	37	X	54117842	54117842	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:54117842G>A	ENST00000375180.2	-	11	2386	c.2330C>T	c.(2329-2331)cCt>cTt	p.P777L	FAM120C_ENST00000328235.4_Missense_Mutation_p.P777L	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	777										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						TCGGCCACCAGGCCACTGAAC	0.443000													24	22					0	0	1	0	0
PI16	221476	broad.mit.edu	37	6	36931644	36931644	+	Missense_Mutation	SNP	C	C	T	rs149360828	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:36931644C>T	ENST00000373674.3	+	6	1644	c.1316C>T	c.(1315-1317)tCg>tTg	p.S439L	PI16_ENST00000491324.1_3'UTR	NM_001199159.1|NM_153370.2	NP_001186088.1|NP_699201.2	Q6UXB8	PI16_HUMAN	peptidase inhibitor 16	439						extracellular region|integral to membrane	peptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GGGCTGAACTCGGGCCCTGGT	0.597000													15	45					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998305	27998305	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:27998305G>A	ENST00000441525.1	-	1	1261	c.1147C>T	c.(1147-1149)Cat>Tat	p.H383Y		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	383										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						TAAACCAGATGATGAGGAGTG	0.413000													33	43					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13762882	13762882	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:13762882C>T	ENST00000265104.4	-	60	10334	c.10230G>A	c.(10228-10230)acG>acA	p.T3410T	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3410	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCATAGCTTTCGTCCAGGAAC	0.453000									Kartagener syndrome				30	55					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104898359	104898359	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:104898359C>T	ENST00000507740.1	+	2	1192	c.956C>T	c.(955-957)tCg>tTg	p.S319L	RIMS2_ENST00000436393.2_Missense_Mutation_p.S289L|RIMS2_ENST00000406091.3_Missense_Mutation_p.S511L|RIMS2_ENST00000262231.10_Missense_Mutation_p.S319L	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	542					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.S289L(1)|p.S547L(1)|p.S319L(1)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CGCCAGATTTCGTTGAGCAGT	0.428000										HNSCC(12;0.0054)			18	100					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107866963	107866963	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:107866963C>T	ENST00000370067.1	+	3	933	c.306C>T	c.(304-306)ccC>ccT	p.P102P	NTNG1_ENST00000370066.1_Silent_p.P102P|NTNG1_ENST00000477948.1_3'UTR|NTNG1_ENST00000370068.1_Silent_p.P102P|NTNG1_ENST00000370070.2_Silent_p.P102P|NTNG1_ENST00000370071.2_Silent_p.P102P|NTNG1_ENST00000370072.3_Silent_p.P102P|NTNG1_ENST00000370073.2_Silent_p.P102P|NTNG1_ENST00000370074.4_Silent_p.P102P|NTNG1_ENST00000542803.1_Silent_p.P102P|NTNG1_ENST00000370061.3_Silent_p.P102P|NTNG1_ENST00000370065.1_Silent_p.P102P			Q9Y2I2	NTNG1_HUMAN	netrin G1	102	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		TGGCACACCCCCCTGAGCTGA	0.488000													89	288					0	0	1	0	0
FAM46C	54855	broad.mit.edu	37	1	118166124	118166124	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:118166124G>A	ENST00000369448.3	+	2	881	c.634G>A	c.(634-636)Ggg>Agg	p.G212R		NM_017709.3	NP_060179.2	Q5VWP2	FA46C_HUMAN	family with sequence similarity 46, member C	212										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	15	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CACCGTGATTGGGGAGAGCAT	0.488000			"""Mis, F, O"""		MM					Multiple Myeloma(3;1.13e-06)			39	114					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20495366	20495366	+	RNA	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:20495366G>A	ENST00000555186.1	+	0	569					NR_038836.1																						TCCCTCACAGGATGAAGACAT	0.418000													11	248					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584978	179584978	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179584978G>A	ENST00000589042.1	-	81	23615	c.23391C>T	c.(23389-23391)ttC>ttT	p.F7797F	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.F6553F|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.F7480F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7480	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTTTTCACGAATCGTGGAG	0.438000													22	70					0	0	1	0	0
TRBV6-7	28600	broad.mit.edu	37	7	142143766	142143766	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:142143766C>T	ENST00000390373.2	-	0	229																											GGGAACTTCTCCTTTGTCAGT	0.478000													109	88					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179546359	179546359	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:179546359G>A	ENST00000393371.2	-	7	1190	c.894C>T	c.(892-894)ctC>ctT	p.L298L	RASGEF1C_ENST00000519883.1_5'UTR|RASGEF1C_ENST00000522500.1_Silent_p.L147L|RASGEF1C_ENST00000361132.4_Silent_p.L298L			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	298	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGATGGCCATGAGGGAGTTGA	0.642000													26	61					0	0	1	0	0
POGLUT1	56983	broad.mit.edu	37	3	119190249	119190249	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:119190249G>A	ENST00000295588.4	+	3	354	c.270G>A	c.(268-270)caG>caA	p.Q90Q		NM_152305.2	NP_689518.1	Q8NBL1	PGLT1_HUMAN	protein O-glucosyltransferase 1	90						endoplasmic reticulum lumen	UDP-glucosyltransferase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(1)	16						CCCACTATCAGATCACTAAGA	0.458000													65	185					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60059730	60059730	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:60059730G>A	ENST00000397786.2	-	16	3710	c.3634C>T	c.(3634-3636)Cct>Tct	p.P1212S		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1212					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CCACTTTTAGGAAAAGGATCT	0.383000													47	124					0	0	1	0	0
NUP210P1	255330	broad.mit.edu	37	3	126386065	126386065	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:126386065C>T	ENST00000357061.3	+	0	517					NR_034158.1																						CACCGATGTCCATCTATATCA	0.582000													14	40					0	0	1	0	0
THBS3	7059	broad.mit.edu	37	1	155170762	155170762	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:155170762C>T	ENST00000368378.3	-	13	1494	c.1474G>A	c.(1474-1476)Gaa>Aaa	p.E492K	RP11-263K19.4_ENST00000453136.1_RNA|THBS3_ENST00000428962.2_Missense_Mutation_p.E342K|RP11-263K19.4_ENST00000422665.1_RNA|THBS3_ENST00000487250.1_5'UTR|RP11-263K19.4_ENST00000430312.1_RNA|THBS3_ENST00000457183.2_Missense_Mutation_p.E372K|THBS3_ENST00000541990.1_Missense_Mutation_p.E21K|THBS3_ENST00000541576.1_5'UTR	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	492					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCAGCATCTTCCTGCCCAGAG	0.552000													95	343					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35944206	35944206	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:35944206C>T	ENST00000297866.5	+	2	388	c.322C>T	c.(322-324)Cat>Tat	p.H108Y		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	108										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GGTGGAATATCATCCTGATAA	0.368000													19	18					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11593453	11593453	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:11593453G>T	ENST00000262442.3	+	20	4382	c.4314G>T	c.(4312-4314)aaG>aaT	p.K1438N	DNAH9_ENST00000454412.2_Missense_Mutation_p.K1438N	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1438	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AAACCTTAAAGGAGCTGCAGA	0.552000													13	54					3.27435e-08	3.30788e-08	1	1	0
NPC1L1	29881	broad.mit.edu	37	7	44556925	44556925	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:44556925C>T	ENST00000289547.4	-	16	3304	c.3249G>A	c.(3247-3249)ctG>ctA	p.L1083L	NPC1L1_ENST00000546276.1_Silent_p.L1010L|NPC1L1_ENST00000381160.3_Silent_p.L1056L	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1083					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GTGAGTTTTTCAGGGGCTTGT	0.557000													40	119					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594888	179594888	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179594888C>T	ENST00000589042.1	-	62	18463	c.18239G>A	c.(18238-18240)gGa>gAa	p.G6080E	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.G4836E|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.G5763E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5763	Ig-like 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATGTAGGTTCCAGAATCGGT	0.463000													16	35					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67815268	67815268	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:67815268G>A	ENST00000265686.3	+	12	1568	c.1460G>A	c.(1459-1461)tGg>tAg	p.W487*	TCIRG1_ENST00000532635.1_Nonsense_Mutation_p.W271*	NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	487					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						CAGTCTGGCTGGAGGTGAGGC	0.692000													55	196					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124358289	124358289	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:124358289G>A	ENST00000368909.3	+	26	3062		c.e26-1		DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Splice_Site|DMBT1_ENST00000368955.3_Splice_Site|DMBT1_ENST00000344338.3_Splice_Site|DMBT1_ENST00000338354.3_Splice_Site|DMBT1_ENST00000368956.2_Splice_Site	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1						epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTCCCCTGTAGGATCTGAATC	0.527000													7	443					0	0	1	0	0
ABCG5	64240	broad.mit.edu	37	2	44049980	44049980	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:44049980G>A	ENST00000543989.1	-	6	1939	c.234C>T	c.(232-234)ccC>ccT	p.P78P	ABCG5_ENST00000405322.1_Silent_p.P302P|ABCG5_ENST00000260645.1_Silent_p.P473P			Q9H222	ABCG5_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 5	473	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAACGCTGAAGGGGAGGACGT	0.592000													23	54					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21646061	21646061	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:21646061G>A	ENST00000328843.6	+	19	3697	c.3666G>A	c.(3664-3666)tgG>tgA	p.W1222*	DNAH11_ENST00000409508.3_Nonsense_Mutation_p.W1222*			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1222	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CTGAAAGATGGGAAACTACCA	0.363000									Kartagener syndrome				6	38					0	0	1	0	0
FZD8	8325	broad.mit.edu	37	10	35928313	35928313	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:35928313G>A	ENST00000374694.1	-	1	2049	c.2045C>T	c.(2044-2046)tCc>tTc	p.S682F		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	682					axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						ATAAGACACGGAGCTCGCCGT	0.746000													3	11					0	0	1	0	0
NTN4	59277	broad.mit.edu	37	12	96052937	96052937	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:96052937C>T	ENST00000343702.4	-	10	2260	c.1812G>A	c.(1810-1812)atG>atA	p.M604I	NTN4_ENST00000344911.4_Missense_Mutation_p.M567I|NTN4_ENST00000538383.1_Missense_Mutation_p.M567I|NTN4_ENST00000553059.1_Missense_Mutation_p.M581I|PGAM1P5_ENST00000552554.1_RNA	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	604	NTR.				axon guidance	basement membrane|plasma membrane				NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						CAAAGCTTTTCATATTCACAA	0.358000													33	82					0	0	1	0	0
TTC31	64427	broad.mit.edu	37	2	74717484	74717484	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:74717484C>T	ENST00000410003.1	+	4	355	c.346C>T	c.(346-348)Cct>Tct	p.P116S	TTC31_ENST00000463189.1_3'UTR|TTC31_ENST00000442235.2_5'UTR|TTC31_ENST00000233623.5_Missense_Mutation_p.P116S			Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	116							binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						CTTCCTGTATCCTCCCCAAGA	0.597000													17	72					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123842258	123842258	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:123842258G>A	ENST00000369005.1	+	4	583	c.243G>A	c.(241-243)agG>agA	p.R81R	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000334433.3_Silent_p.R81R|TACC2_ENST00000515273.1_Silent_p.R81R|TACC2_ENST00000515603.1_Silent_p.R81R|TACC2_ENST00000453444.2_Silent_p.R81R	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	81						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTGAGCCAAGGAAGGACCCAC	0.632000													33	59					0	0	1	0	0
SHBG	6462	broad.mit.edu	37	17	7535018	7535018	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:7535018C>T	ENST00000380450.4	+	5	698	c.667C>T	c.(667-669)Ccc>Tcc	p.P223S	SHBG_ENST00000572182.1_Intron|SHBG_ENST00000575903.1_Missense_Mutation_p.P205S|SHBG_ENST00000441599.2_Missense_Mutation_p.P223S|SHBG_ENST00000416273.3_Missense_Mutation_p.P223S|SHBG_ENST00000340624.5_Missense_Mutation_p.P165S|SHBG_ENST00000572262.1_Missense_Mutation_p.P111S|SHBG_ENST00000574539.1_Missense_Mutation_p.P165S|SHBG_ENST00000570547.1_Missense_Mutation_p.P165S|SHBG_ENST00000575314.1_Missense_Mutation_p.P165S|SHBG_ENST00000576728.1_Missense_Mutation_p.P111S|SHBG_ENST00000576478.1_Missense_Mutation_p.P111S	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin	223					hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	AGAATCAAATCCCGGGATATT	0.562000													133	346					0	0	1	0	0
GTF2F1	2962	broad.mit.edu	37	19	6380619	6380619	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:6380619G>A	ENST00000394456.5	-	12	1778	c.1314C>T	c.(1312-1314)ccC>ccT	p.P438P	GTF2F1_ENST00000429701.2_Silent_p.P353P	NM_002096.2	NP_002087.2	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1, 74kDa	438					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)	16						ATGGTGGCTGGGGTGTCGACT	0.637000													33	89					0	0	1	0	0
PPWD1	23398	broad.mit.edu	37	5	64867904	64867904	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:64867904C>T	ENST00000261308.5	+	5	832	c.760C>T	c.(760-762)Cct>Tct	p.P254S	PPWD1_ENST00000535264.1_Missense_Mutation_p.P224S|PPWD1_ENST00000538977.1_Missense_Mutation_p.P98S	NM_015342.3	NP_056157.1	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat containing 1	254					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	19		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)		GACTGGGCCTCCTCATGAATA	0.398000													33	112					0	0	1	0	0
IDUA	3425	broad.mit.edu	37	4	995265	995265	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:995265G>A	ENST00000453894.1	+	4	450	c.362G>A	c.(361-363)gGa>gAa	p.G121E	IDUA_ENST00000514224.1_Missense_Mutation_p.G36E|IDUA_ENST00000247933.4_Missense_Mutation_p.G168E			P35475	IDUA_HUMAN	iduronidase, alpha-L-	168					disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)	GGTAGGTACGGACTGGCGCAT	0.582000													38	143					0	0	1	0	0
MPDZ	8777	broad.mit.edu	37	9	13150516	13150516	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:13150516G>A	ENST00000319217.7	-	25	3871	c.3624C>T	c.(3622-3624)atC>atT	p.I1208I	MPDZ_ENST00000538841.1_Silent_p.I100I|MPDZ_ENST00000447879.1_Silent_p.I1208I|MPDZ_ENST00000546205.1_Silent_p.I1222I|MPDZ_ENST00000381015.4_Silent_p.I1208I|MPDZ_ENST00000381022.2_Silent_p.I1208I|MPDZ_ENST00000541718.1_Silent_p.I1208I|MPDZ_ENST00000536827.1_Silent_p.I1208I	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1208	PDZ 7.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		GTACCTCTACGATTCTATCTC	0.338000													64	161					0	0	1	0	0
GEMIN7	79760	broad.mit.edu	37	19	45593701	45593701	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:45593701C>T	ENST00000270257.4	+	3	576	c.329C>T	c.(328-330)cCc>cTc	p.P110L	GEMIN7_ENST00000591747.1_Missense_Mutation_p.P110L|GEMIN7_ENST00000591607.1_Missense_Mutation_p.P110L|GEMIN7_ENST00000391951.2_Missense_Mutation_p.P110L	NM_001007269.1|NM_001007270.1|NM_024707.2	NP_001007270.1|NP_001007271.1|NP_078983.1	Q9H840	GEMI7_HUMAN	gem (nuclear organelle) associated protein 7	110					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			endometrium(1)|kidney(1)|lung(4)|ovary(1)	7		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		CTGCAGACTCCCATAGGTGTG	0.517000													45	87					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81969780	81969780	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:81969780C>T	ENST00000359376.3	+	27	3063	c.2849C>T	c.(2848-2850)cCt>cTt	p.P950L		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	950	PI-PLC Y-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						GCAGAAAATCCTGACTTCCGA	0.458000													16	46					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57641750	57641750	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:57641750G>A	ENST00000254181.4	+	4	2161	c.1707G>A	c.(1705-1707)atG>atA	p.M569I	USP29_ENST00000598197.1_Missense_Mutation_p.M569I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	569					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CTCAGGAGATGATTTCTGAGA	0.468000													41	122					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67815269	67815269	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:67815269G>A	ENST00000265686.3	+	12	1569	c.1461G>A	c.(1459-1461)tgG>tgA	p.W487*	TCIRG1_ENST00000532635.1_Nonsense_Mutation_p.W271*	NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	487					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						AGTCTGGCTGGAGGTGAGGCC	0.692000													55	190					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22404390	22404390	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:22404390C>T	ENST00000334304.5	-	15	2534	c.2265G>A	c.(2263-2265)gcG>gcA	p.A755A	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	755					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				GGAGGCTGGCCGCCTGGGTGT	0.428000													36	72					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110494908	110494908	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:110494908C>T	ENST00000260283.4	-	5	765	c.481G>A	c.(481-483)Gtg>Atg	p.V161M	ARHGAP20_ENST00000357139.3_Missense_Mutation_p.V135M|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.V135M|ARHGAP20_ENST00000524756.1_Missense_Mutation_p.V138M|ARHGAP20_ENST00000528829.1_Missense_Mutation_p.V125M|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.V125M	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	161	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		ACAAAGTTCACTGTGGGCCAG	0.388000													16	46					0	0	1	0	0
DLL4	54567	broad.mit.edu	37	15	41222069	41222069	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:41222069C>T	ENST00000249749.5	+	2	367	c.91C>T	c.(91-93)Cag>Tag	p.Q31*		NM_019074.3	NP_061947.1	Q9NR61	DLL4_HUMAN	delta-like 4 (Drosophila)	31					blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(3)|large_intestine(1)	4		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CGGCGTCTTCCAGCTGCAGCT	0.692000													11	54					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33987146	33987146	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:33987146G>A	ENST00000373381.4	-	68	10690	c.10514C>T	c.(10513-10515)tCg>tTg	p.S3505L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3361						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGACTCTGACGAGACCTGTGA	0.567000													20	52					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196352	207196352	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:207196352C>T	ENST00000359470.5	-	4	1006	c.757G>A	c.(757-759)Gaa>Aaa	p.E253K	C1orf116_ENST00000461135.2_Missense_Mutation_p.E7K	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	253						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					GAGACTGTTTCCTTGGCTTTT	0.587000													145	208					0	0	1	0	0
HOXA6	3203	broad.mit.edu	37	7	27187306	27187306	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:27187306G>A	ENST00000222728.3	-	1	87	c.63C>T	c.(61-63)ttC>ttT	p.F21F	HOXA3_ENST00000467897.2_Intron|HOXA-AS3_ENST00000518947.2_RNA|HOXA-AS3_ENST00000518848.1_RNA|HOXA6_ENST00000521478.1_Intron|HOXA-AS3_ENST00000521197.1_RNA|HOXA-AS3_ENST00000521231.1_RNA	NM_024014.3	NP_076919.1	P31267	HXA6_HUMAN	homeobox A6	21						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|lung(3)|ovary(1)	10						GCTGGCCCAAGAAGGAGTCCT	0.607000													19	65					0	0	1	0	0
SLC1A1	6505	broad.mit.edu	37	9	4572216	4572216	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:4572216G>A	ENST00000262352.3	+	7	831	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	199					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	CAAAACAAAGGAATACAAAAT	0.368000													53	185					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138568	126138568	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:126138568C>T	ENST00000299308.3	+	9	2557	c.2549C>T	c.(2548-2550)cCc>cTc	p.P850L	TMEM132B_ENST00000535886.1_Missense_Mutation_p.P362L	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	850						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGCACAACCCCCCAGTCTCCC	0.517000													21	57					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347778	91347778	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:91347778C>T	ENST00000358859.2	-	1	1175	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		TACAGAGTTTCCTGCAGTCCC	0.622000													150	416					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13913897	13913897	+	Silent	SNP	T	T	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:13913897T>C	ENST00000265104.4	-	11	1595	c.1491A>G	c.(1489-1491)caA>caG	p.Q497Q		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	497	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTGTGGAATCTTGCAGGACTG	0.358000									Kartagener syndrome				31	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569999	179569999	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179569999C>T	ENST00000589042.1	-	103	29730	c.29506G>A	c.(29506-29508)Gaa>Aaa	p.E9836K	TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.E8592K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E9519K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9519	Ig-like 79.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATATTTTTCATATTCTTTA	0.368000													23	48					0	0	1	0	0
NOP2	4839	broad.mit.edu	37	12	6672803	6672803	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:6672803G>A	ENST00000541778.1	-	7	1141	c.653C>T	c.(652-654)cCc>cTc	p.P218L	NOP2_ENST00000399466.2_Missense_Mutation_p.P218L|NOP2_ENST00000542015.1_Intron|NOP2_ENST00000537442.1_Missense_Mutation_p.P222L|NOP2_ENST00000545200.1_Missense_Mutation_p.P218L|NOP2_ENST00000322166.5_Missense_Mutation_p.P222L|NOP2_ENST00000382421.3_Missense_Mutation_p.P255L			P46087	NOP2_HUMAN	NOP2 nucleolar protein	222					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	19						CCCAGCAGGGGGCAGCACAAA	0.557000											OREG0021630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	41					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048875	9048875	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:9048875G>A	ENST00000397910.4	-	5	32959	c.32756C>T	c.(32755-32757)tCt>tTt	p.S10919F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10921	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGAATAGCAGAACTGGCTTC	0.488000													41	138					0	0	1	0	0
UBA52	7311	broad.mit.edu	37	19	18684476	18684476	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:18684476C>T	ENST00000442744.2	+	3	166	c.108C>T	c.(106-108)atC>atT	p.I36I	UBA52_ENST00000430157.2_Silent_p.I36I|UBA52_ENST00000599551.1_Silent_p.I36I|UBA52_ENST00000597451.1_Silent_p.I36I|UBA52_ENST00000596304.1_Silent_p.I36I|UBA52_ENST00000596273.1_Silent_p.I36I|UBA52_ENST00000598780.1_Silent_p.I36I|UBA52_ENST00000595683.1_Silent_p.I36I|UBA52_ENST00000595158.1_Silent_p.I36I|CRLF1_ENST00000594325.1_Intron|UBA52_ENST00000599595.1_Silent_p.I36I	NM_001033930.1	NP_001029102.1	P62987	RL40_HUMAN	ubiquitin A-52 residue ribosomal protein fusion product 1	36	Ubiquitin-like.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane|ribosome	protein binding|structural constituent of ribosome			endometrium(1)|large_intestine(2)	3						CCTCAGGTATCCCACCTGACC	0.572000													27	84					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92848781	92848781	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:92848781G>A	ENST00000341723.4	-	1	114	c.27C>T	c.(25-27)ttC>ttT	p.F9F	HEPACAM2_ENST00000453812.2_Intron|HEPACAM2_ENST00000394468.2_Intron|HEPACAM2_ENST00000440868.1_Silent_p.F9F	NM_198151.1	NP_937794.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	0						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						CAAAGGAAAGGAAAGTTGTGA	0.498000													41	119					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220342127	220342127	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:220342127G>A	ENST00000312358.7	+	20	4821	c.4689G>A	c.(4687-4689)gcG>gcA	p.A1563A	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1563	Ig-like 8.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGAACCTGGCGGGTGAGGTCT	0.597000													4	10					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57115245	57115245	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:57115245G>A	ENST00000439986.4	-	7	782	c.745C>T	c.(745-747)Cct>Tct	p.P249S	CCBE1_ENST00000398179.2_Silent_p.L24L	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	249	Collagen-like 1.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				GGCAGGCCAGGAGGTCCTGGA	0.577000													43	98					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62065171	62065171	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:62065171G>A	ENST00000354587.3	-	8	1285	c.1109C>T	c.(1108-1110)cCc>cTc	p.P370L	KCNQ2_ENST00000430658.1_Missense_Mutation_p.P370L|KCNQ2_ENST00000359689.1_Missense_Mutation_p.P370L|KCNQ2_ENST00000370224.1_Missense_Mutation_p.P370L|KCNQ2_ENST00000344425.5_Missense_Mutation_p.P370L|KCNQ2_ENST00000482957.1_5'UTR|KCNQ2_ENST00000370222.3_Missense_Mutation_p.P370L|KCNQ2_ENST00000370226.1_Missense_Mutation_p.P370L|KCNQ2_ENST00000360480.3_Missense_Mutation_p.P370L|KCNQ2_ENST00000370221.1_Missense_Mutation_p.P370L|KCNQ2_ENST00000344462.3_Missense_Mutation_p.P370L|KCNQ2_ENST00000357249.2_Missense_Mutation_p.P370L|KCNQ2_ENST00000359125.2_Missense_Mutation_p.P370L			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	370					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CCTGTACATGGGCACGGTGAC	0.517000													37	110					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241976279	241976279	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:241976279C>T	ENST00000310397.8	+	5	878	c.878C>T	c.(877-879)cCc>cTc	p.P293L	SNED1_ENST00000405547.3_Missense_Mutation_p.P293L|SNED1_ENST00000401884.1_Missense_Mutation_p.P293L|SNED1_ENST00000342631.6_Missense_Mutation_p.P293L|AC005237.4_ENST00000458377.1_RNA	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	293	EGF-like 1.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		ACGGGCAACCCCTCCTACACC	0.706000													13	36					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961290	34961290	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:34961290G>A	ENST00000329357.5	+	1	378	c.342G>A	c.(340-342)cgG>cgA	p.R114R		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	114										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						AGCCAGCACGGAAGGCGTTCG	0.532000													42	47					0	0	1	0	0
BICD1	636	broad.mit.edu	37	12	32487522	32487522	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:32487522A>G	ENST00000548411.1	+	6	2354	c.2173A>G	c.(2173-2175)Acg>Gcg	p.T725A	BICD1_ENST00000281474.5_Missense_Mutation_p.T725A	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	725	Interacts with RAB6A.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			TGAAACCATGACGAAGCTTAG	0.393000													25	102					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276189	152276189	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:152276189C>A	ENST00000368799.1	-	3	11208	c.11173G>T	c.(11173-11175)Gga>Tga	p.G3725*	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3725	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGCCCGTCCATGGGCAGAC	0.607000									Ichthyosis				173	630					6.92943e-93	7.1592e-93	1	1	0
SCN4A	6329	broad.mit.edu	37	17	62041036	62041036	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:62041036C>T	ENST00000578147.1	-	10	1678	c.1602G>A	c.(1600-1602)atG>atA	p.M534I	SCN4A_ENST00000435607.1_Missense_Mutation_p.M534I			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	534					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	ACTCACCTTCCATGGCGTCGG	0.627000													5	17					0	0	1	0	0
PTPN11	5781	broad.mit.edu	37	12	112884098	112884098	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:112884098C>T	ENST00000351677.2	+	2	231	c.33C>T	c.(31-33)atC>atT	p.I11I	PTPN11_ENST00000392597.1_Silent_p.I11I	NM_002834.3	NP_002825.3	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type 11	11	SH2 1.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(406)|kidney(2)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(3)|stomach(3)	451						ACCCAAATATCACTGGTGTGG	0.408000			Mis		"""JMML, AML, MDS"""		Noonan Syndrome		Noonan syndrome				39	92					0	0	1	0	0
TMEM88	92162	broad.mit.edu	37	17	7758455	7758455	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:7758455C>T	ENST00000301599.6	+	1	73	c.63C>T	c.(61-63)ccC>ccT	p.P21P	TMEM88_ENST00000574668.1_Silent_p.P21P	NM_203411.1	NP_981956.1	Q6PEY1	TMM88_HUMAN	transmembrane protein 88	21						integral to membrane				lung(1)	1		all_cancers(10;0.00528)|Prostate(122;0.202)				CCCGGGACCCCCTGGACTGTT	0.672000													7	24					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70146619	70146619	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:70146619A>T	ENST00000335568.5	+	1	403	c.401A>T	c.(400-402)aAg>aTg	p.K134M	UGT2B28_ENST00000511240.1_Missense_Mutation_p.K134M	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	134					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GTTTCAAATAAGAAAGTTATG	0.333000													40	123					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218682926	218682926	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:218682926C>T	ENST00000171887.4	-	24	4269	c.3817G>A	c.(3817-3819)Ggc>Agc	p.G1273S	TNS1_ENST00000430930.1_Missense_Mutation_p.G1252S|TNS1_ENST00000419504.1_Missense_Mutation_p.G1260S	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1273						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGGTGCCGGCCCAGGCTGGGA	0.682000													16	35					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21102932	21102932	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:21102932G>T	ENST00000377122.4	-	23	2678	c.2282C>A	c.(2281-2283)cCa>cAa	p.P761Q	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	761					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AATCAGACTTGGTCTACCTTT	0.333000													16	65					2.48551e-13	2.51525e-13	1	1	0
C19orf44	84167	broad.mit.edu	37	19	16625374	16625374	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:16625374C>T	ENST00000221671.3	+	7	1958	c.1802C>T	c.(1801-1803)aCg>aTg	p.T601M	CTD-3222D19.2_ENST00000409035.1_Intron|C19orf44_ENST00000594035.1_Missense_Mutation_p.T569M	NM_032207.2	NP_115583.1	Q9H6X5	CS044_HUMAN	chromosome 19 open reading frame 44	601										endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	16						CTGAGCCTGACGCAGCAGTTC	0.652000													10	26					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	39980082	39980082	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:39980082C>T	ENST00000308666.3	-	7	1799	c.1664G>A	c.(1663-1665)gGa>gAa	p.G555E		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	555	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						CCGAAGACTTCCAAGAGACAT	0.393000													35	65					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138413176	138413176	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:138413176G>A	ENST00000409968.1	+	22	4229	c.4051G>A	c.(4051-4053)Gaa>Aaa	p.E1351K	THSD7B_ENST00000272643.3_Missense_Mutation_p.E1354K|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Missense_Mutation_p.E1323K					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ACTGTGTGGAGAAATGCCCTT	0.527000													10	21					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139884529	139884529	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:139884529C>T	ENST00000297183.6	+	16	3252	c.3128C>T	c.(3127-3129)cCt>cTt	p.P1043L	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P1043L|ANKHD1_ENST00000360839.2_Missense_Mutation_p.P1043L	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGTGTATCCTTCAGTTGAC	0.398000													43	120					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199453	4199453	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:4199453G>A	ENST00000296358.4	-	5	1132	c.1108C>T	c.(1108-1110)Cgg>Tgg	p.R370W		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	370					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTGTAAATCCGGATTCCAGCC	0.582000													39	106					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42295712	42295712	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:42295712C>T	ENST00000379310.3	-	25	2827		c.e25-1		VWA8_ENST00000281496.6_Splice_Site	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		AAAATATCACCTAAAGGAGAG	0.438000													11	44					0	0	1	0	0
F2RL3	9002	broad.mit.edu	37	19	17001362	17001362	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:17001362C>T	ENST00000248076.3	+	2	1418	c.1088C>T	c.(1087-1089)aCc>aTc	p.T363I		NM_003950.2	NP_003941.2	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	363					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						CCGGGGGACACCGTGGCCTCC	0.637000													6	18					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121384967	121384967	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:121384967C>T	ENST00000260197.7	+	8	1277	c.1148C>T	c.(1147-1149)tCc>tTc	p.S383F	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	383					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CTGAAGTTCTCCCTGTCCTTG	0.542000													26	63					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354861	45354861	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:45354861C>T	ENST00000359271.2	+	2	1436	c.1186C>T	c.(1186-1188)Cct>Tct	p.P396S		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	396						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				CTCTGCCCTCCCTGGGCCCCC	0.637000													23	57					0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52497049	52497049	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:52497049G>A	ENST00000602063.1	-	6	1629	c.1280C>T	c.(1279-1281)cCt>cTt	p.P427L	ZNF615_ENST00000391795.3_Missense_Mutation_p.P432L|ZNF615_ENST00000376716.5_Missense_Mutation_p.P427L|ZNF615_ENST00000598071.1_Missense_Mutation_p.P438L|ZNF615_ENST00000594083.1_Missense_Mutation_p.P438L			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GCATTTATAAGGTTTCTCTCC	0.418000													14	84					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36707395	36707395	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:36707395G>A	ENST00000264659.7	-	15	3182	c.2958C>T	c.(2956-2958)ggC>ggT	p.G986G	SRCIN1_ENST00000578925.1_Silent_p.G1020G|SRCIN1_ENST00000398579.4_5'UTR	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	858					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						CCATACCTGAGCCCCTCCTCC	0.687000													4	18					0	0	1	0	0
C16orf45	89927	broad.mit.edu	37	16	15675129	15675129	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:15675129C>T	ENST00000300006.4	+	4	719	c.360C>T	c.(358-360)atC>atT	p.I120I	C16orf45_ENST00000452191.2_Silent_p.I103I|C16orf45_ENST00000566490.1_Silent_p.I120I|C16orf45_ENST00000565913.1_3'UTR|C16orf45_ENST00000561692.1_Silent_p.I72I	NM_033201.2	NP_149978.1	Q96MC5	CP045_HUMAN	chromosome 16 open reading frame 45	120										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)	11						TCCAGAAGATCCACAAACTGG	0.502000													12	42					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49355505	49355505	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:49355505G>A	ENST00000263265.6	-	13	1960	c.1405C>T	c.(1405-1407)Ctg>Ttg	p.L469L	PLEKHA4_ENST00000355496.5_Silent_p.L444L	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	469						cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		CCAAGGTGCAGCAGGTACTCC	0.552000													32	113					0	0	1	0	0
LAYN	143903	broad.mit.edu	37	11	111425979	111425979	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:111425979G>A	ENST00000436913.2	+	4	588	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	LAYN_ENST00000375615.3_Missense_Mutation_p.E216K|LAYN_ENST00000375614.2_Missense_Mutation_p.E208K|LAYN_ENST00000528924.1_3'UTR|LAYN_ENST00000533265.1_Missense_Mutation_p.E208K|LAYN_ENST00000525126.1_Missense_Mutation_p.E216K	NM_001258391.1	NP_001245320.1	Q6UX15	LAYN_HUMAN	layilin	216	C-type lectin.					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|skin(1)	14		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		AGAAACACAGGAAGAAGATGC	0.398000													22	63					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119749443	119749443	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:119749443G>A	ENST00000541757.1	+	15	1345	c.965G>A	c.(964-966)gGa>gAa	p.G322E	MARCO_ENST00000327097.4_Missense_Mutation_p.G400E			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	400	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity	p.G400V(2)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						GGAGACCAGGGAGTGAAAGGT	0.547000													5	14					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93567917	93567917	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:93567917G>A	ENST00000394196.4	+	39	6537	c.5469G>A	c.(5467-5469)tgG>tgA	p.W1823*		NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1823					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			ATTATAACTGGAATGTTCGGA	0.438000													25	44					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345951	92345951	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:92345951G>A	ENST00000377067.3	+	3	1208	c.836G>A	c.(835-837)cGa>cAa	p.R279Q		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	279						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AATGTCATGCGAGGCTGCCTG	0.537000													34	111					0	0	1	0	0
ANAPC1	64682	broad.mit.edu	37	2	112622497	112622497	+	Silent	SNP	A	A	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:112622497A>C	ENST00000341068.3	-	8	1489	c.717T>G	c.(715-717)gtT>gtG	p.V239V		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	239					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						CATGATCTACAACATATTGCA	0.353000													30	98					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28542702	28542702	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:28542702G>A	ENST00000452236.2	-	3	2397	c.1780C>T	c.(1780-1782)Cct>Tct	p.P594S		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	594					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						CTGCTCTCAGGAGGGCTTTTT	0.373000													14	65					0	0	1	0	0
RPP40	10799	broad.mit.edu	37	6	4995314	4995314	+	Nonstop_Mutation	SNP	A	A	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:4995314A>T	ENST00000380051.2	-	8	1134	c.1090T>A	c.(1090-1092)Taa>Aaa	p.*364K	RPP40_ENST00000464646.1_Nonstop_Mutation_p.*304K|RPP40_ENST00000319533.5_Nonstop_Mutation_p.*341K	NM_006638.2	NP_006629.2	O75818	RPP40_HUMAN	ribonuclease P/MRP 40kDa subunit	0					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			NS(1)|breast(1)|large_intestine(4)|lung(4)|ovary(1)|skin(2)|urinary_tract(1)	14	Ovarian(93;0.11)	all_hematologic(90;0.0895)				tttattttttatGGTGGACAG	0.348000													28	77					0	0	1	0	0
BEST2	54831	broad.mit.edu	37	19	12863524	12863524	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:12863524C>T	ENST00000549706.1	+	2	442	c.118C>T	c.(118-120)Ctt>Ttt	p.L40F	BEST2_ENST00000042931.1_Missense_Mutation_p.L40F|BEST2_ENST00000553030.1_Missense_Mutation_p.L40F			Q8NFU1	BEST2_HUMAN	bestrophin 2	40					membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			breast(3)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)	12						GCTCTGCTTCCTTGGGTTCTA	0.572000													22	67					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196342309	196342309	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:196342309G>A	ENST00000367433.5	-	14	1465	c.1364C>T	c.(1363-1365)tCt>tTt	p.S455F	KCNT2_ENST00000294725.8_Missense_Mutation_p.S455F|KCNT2_ENST00000367431.4_Missense_Mutation_p.S455F|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Missense_Mutation_p.S66F			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	455	RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						AATAAGTGTAGATGTTGCTGG	0.294000													36	165					0	0	1	0	0
MARCKSL1	65108	broad.mit.edu	37	1	32800433	32800433	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:32800433G>A	ENST00000329421.7	-	2	698	c.353C>T	c.(352-354)gCc>gTc	p.A118V		NM_023009.6	NP_075385.1	P49006	MRP_HUMAN	MARCKS-like 1	118						plasma membrane	calmodulin binding			breast(1)|large_intestine(3)|lung(1)|ovary(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GGGTGAGGAGGCAGAAGAATC	0.572000													30	88					0	0	1	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114107704	114107704	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:114107704G>A	ENST00000375418.3	-	1	135	c.49C>T	c.(49-51)Ctt>Ttt	p.L17F		NM_138430.3	NP_612439.2	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	17					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CTGTAGCCAAGAGCATCGCCG	0.587000													35	63					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25485039	25485039	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:25485039C>T	ENST00000453082.2	+	0	1979				SNORD115-38_ENST00000365037.1_RNA	NR_003343.1																						ACTTAAAAATCATGCTCAATA	0.512000													137	419					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103307719	103307719	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:103307719C>T	ENST00000520539.1	-	30	4460	c.3854G>A	c.(3853-3855)aGg>aAg	p.R1285K	UBR5_ENST00000220959.4_Missense_Mutation_p.R1285K|UBR5_ENST00000521922.1_Missense_Mutation_p.R1279K	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1285					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CACCGTCTGCCTTGCGACTGT	0.483000													39	180					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28823722	28823722	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:28823722G>A	ENST00000422425.2	+	35	2532	c.2488G>A	c.(2488-2490)Gat>Aat	p.D830N	PLB1_ENST00000327757.5_Missense_Mutation_p.D841N	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	841	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					gatgaaagatgatcatgtgag	0.418000													12	42					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38835405	38835405	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:38835405C>T	ENST00000449082.2	-	1	96	c.97G>A	c.(97-99)Gga>Aga	p.G33R		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	33					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTCTTTGTTCCCTGCTTGGCA	0.517000													79	179					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55315821	55315821	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:55315821C>T	ENST00000536015.1	-	28	3774	c.3655G>A	c.(3655-3657)Gac>Aac	p.D1219N	RP11-35G9.3_ENST00000592201.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.D1219N|RP11-35G9.3_ENST00000591854.1_RNA|RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	1219					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				GAGATGAGGTCCGCGTAGCCC	0.706000													12	53					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150400023	150400023	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:150400023G>A	ENST00000295910.6	-	7	916	c.864C>T	c.(862-864)tcC>tcT	p.S288S	FAM194A_ENST00000491361.1_Silent_p.S142S	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	288										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TTGGTTCAGAGGAAACATCCA	0.378000													28	86					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887606	12887606	+	Missense_Mutation	SNP	C	C	G	rs58074988		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:12887606C>G	ENST00000535591.1	-	3	446	c.251G>C	c.(250-252)tGc>tCc	p.C84S		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	84								p.C84S(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATTGAGGAAGCACCCATGGGC	0.483000													9	462					0	0	1	0	0
HESX1	8820	broad.mit.edu	37	3	57232430	57232430	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:57232430C>T	ENST00000295934.3	-	3	484	c.448G>A	c.(448-450)Gac>Aac	p.D150N	HESX1_ENST00000473921.1_Intron	NM_003865.2	NP_003856.1	Q9UBX0	HESX1_HUMAN	HESX homeobox 1	150						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(1)|ovary(1)|prostate(1)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(284;0.0109)|Kidney(284;0.0126)		TGGATTCTGTCTTCCTCTAGA	0.274000													18	61					0	0	1	0	0
ENO1	2023	broad.mit.edu	37	1	8927218	8927218	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:8927218G>A	ENST00000234590.4	-	6	521	c.402C>T	c.(400-402)atC>atT	p.I134I		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	134	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CCAAGTCAGCGATGTGGCGGT	0.567000													29	89					0	0	1	0	0
CLEC18B	497190	broad.mit.edu	37	16	74443471	74443471	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:74443471C>T	ENST00000339953.5	-	12	1428	c.1307G>A	c.(1306-1308)cGa>cAa	p.R436Q		NM_001011880.2	NP_001011880.2	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	436	C-type lectin.					extracellular region	sugar binding			endometrium(3)|kidney(9)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GTAACGGTTTCGGGTTTTGCA	0.607000													16	111					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328580	80328580	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:80328580C>T	ENST00000358842.3	-	1	792	c.775G>A	c.(775-777)Gac>Aac	p.D259N		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	259					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						GCACATTGGTCCCCCAAACAC	0.458000													44	140					0	0	1	0	0
SYTL5	94122	broad.mit.edu	37	X	37969634	37969634	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:37969634G>A	ENST00000357972.5	+	13	2041	c.1495G>A	c.(1495-1497)Gat>Aat	p.D499N	TM4SF2_ENST00000465127.1_Intron|SYTL5_ENST00000456733.2_Missense_Mutation_p.D521N|SYTL5_ENST00000297875.2_Missense_Mutation_p.D499N			Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5	499	C2 1.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						CTGGCACTATGATCGATTTGG	0.448000													44	40					0	0	1	0	0
PABPC1L	80336	broad.mit.edu	37	20	43545480	43545480	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:43545480C>T	ENST00000255136.3	+	3	553	c.471C>T	c.(469-471)acC>acT	p.T157T	PABPC1L_ENST00000537323.1_Silent_p.T157T|PABPC1L_ENST00000217074.4_Silent_p.T157T|PABPC1L_ENST00000217073.2_Silent_p.T157T	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like	157	RRM 2.						nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						CCATCAACACCATGAATGGGA	0.617000													55	137					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12666526	12666526	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:12666526C>T	ENST00000425538.1	+	14	2726	c.2526C>T	c.(2524-2526)atC>atT	p.I842I	MYOCD_ENST00000343344.4_Silent_p.I794I|RP11-1090M7.1_ENST00000584772.1_RNA	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	794					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCAGCCAGATCCCCTTTGATC	0.483000													41	91					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77918572	77918572	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:77918572C>T	ENST00000302536.2	+	7	1103	c.950C>T	c.(949-951)tCc>tTc	p.S317F		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	317							oxidoreductase activity|zinc ion binding	p.S317F(1)		central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						GCGGGGTTTTCCCTTTTAAAT	0.507000													9	32					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	73000568	73000568	+	Missense_Mutation	SNP	T	T	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:73000568T>A	ENST00000322038.5	+	2	3655	c.3071T>A	c.(3070-3072)aTc>aAc	p.I1024N	TSHZ1_ENST00000580243.1_Missense_Mutation_p.I1069N	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	1069						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		GACCACCTGATCTATGTGACT	0.537000													33	103					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22749257	22749257	+	RNA	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:22749257G>A	ENST00000503442.1	+	0	377				GBA3_ENST00000508166.1_RNA|GBA3_ENST00000511446.1_RNA	NM_001128432.2	NP_001121904.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GCACAGCTATGATTCCTTATT	0.468000													65	142					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220167039	220167039	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:220167039G>A	ENST00000295718.2	-	6	1054	c.814C>T	c.(814-816)Ctt>Ttt	p.L272F	AC114803.3_ENST00000417355.1_RNA|PTPRN_ENST00000423636.2_Missense_Mutation_p.L182F|PTPRN_ENST00000409251.3_Missense_Mutation_p.L272F	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	272					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCTTGAAAAAGCTGGGCAGGT	0.637000													11	32					0	0	1	0	0
IGKV5-2	28907	broad.mit.edu	37	2	89197106	89197106	+	RNA	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:89197106G>A	ENST00000390244.2	+	0	214																											AGACATTGATGATGATATGAA	0.473000													46	140					0	0	1	0	0
AKR1C4	1109	broad.mit.edu	37	10	5254618	5254618	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:5254618G>A	ENST00000380448.1	+	8	863	c.610G>A	c.(610-612)Gat>Aat	p.D204N	AKR1C4_ENST00000263126.1_Missense_Mutation_p.D204N			P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	204					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	18					NADH(DB00157)	CAAACTGCTGGATTTCTGCAA	0.378000													18	61					0	0	1	0	0
NUFIP1	26747	broad.mit.edu	37	13	45554928	45554928	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:45554928A>C	ENST00000379161.4	-	3	569	c.523T>G	c.(523-525)Ttt>Gtt	p.F175V		NM_012345.2	NP_036477.2	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein interacting protein 1	175					box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(4)|skin(3)	18		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		GTATCACAAAAAAAGTGAAAA	0.308000													19	78					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41514491	41514491	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:41514491C>T	ENST00000400454.1	-	18	3877	c.3400G>A	c.(3400-3402)Gac>Aac	p.D1134N		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1134	Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TTACCTCCGTCCATGAGGTTG	0.478000													30	96					0	0	1	0	0
SLC2A5	6518	broad.mit.edu	37	1	9107787	9107787	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:9107787C>T	ENST00000377424.4	-	4	479	c.300G>A	c.(298-300)ggG>ggA	p.G100G	SLC2A5_ENST00000377414.3_Silent_p.G100G|SLC2A5_ENST00000536305.1_Silent_p.G41G|SLC2A5_ENST00000535586.1_5'UTR	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	100					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		ACAGCAAGGCCCCTTTTCTGC	0.418000													32	99					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57116349	57116349	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:57116349C>T	ENST00000262510.6	+	49	5735	c.5510C>T	c.(5509-5511)cCc>cTc	p.P1837L	NLRC5_ENST00000539144.1_Missense_Mutation_p.P1808L|NLRC5_ENST00000436936.1_3'UTR|NLRC5_ENST00000308149.7_Missense_Mutation_p.P1808L	NM_032206.4	NP_115582.4	Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1837					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				AACCCCATTCCCTGCGACATG	0.582000													44	130					0	0	1	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111624195	111624195	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:111624195G>A	ENST00000527614.1	-	9	1201	c.1136C>T	c.(1135-1137)cCt>cTt	p.P379L	PPP2R1B_ENST00000427203.2_Missense_Mutation_p.P218L|PPP2R1B_ENST00000426998.2_Missense_Mutation_p.P315L|PPP2R1B_ENST00000393055.2_Missense_Mutation_p.P252L|PPP2R1B_ENST00000341980.6_Intron|PPP2R1B_ENST00000311129.5_Missense_Mutation_p.P379L	NM_001177562.1|NM_002716.4	NP_001171033.1|NP_002707.3	P30154	2AAB_HUMAN	protein phosphatase 2, regulatory subunit A, beta	379							protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|liver(1)|lung(10)|prostate(1)|urinary_tract(2)	22		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		TAAGAAAAGAGGTAGAAGATG	0.353000													15	54					0	0	1	0	0
ZNF611	81856	broad.mit.edu	37	19	53208210	53208210	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:53208210G>A	ENST00000543227.1	-	6	2372	c.2098C>T	c.(2098-2100)Cat>Tat	p.H700Y	ZNF611_ENST00000453741.2_Missense_Mutation_p.H631Y|ZNF611_ENST00000595798.1_Missense_Mutation_p.H631Y|ZNF611_ENST00000602162.1_Missense_Mutation_p.H631Y|ZNF611_ENST00000319783.1_Missense_Mutation_p.H700Y|ZNF611_ENST00000540744.1_Missense_Mutation_p.H700Y	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	700					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TCTCCAGTATGAATTCTATGA	0.368000													33	129					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271018	1271018	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:1271018G>A	ENST00000447027.1	+	31	12975	c.12917G>A	c.(12916-12918)aGg>aAg	p.R4306K	MUC5B_ENST00000529681.1_Missense_Mutation_p.R4303K			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4303	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCAGTCCAAGGACTGCAACC	0.627000													67	179					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093406	30093406	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:30093406C>T	ENST00000567636.1	+	0	1781					NR_003558.1																						CCCACCAGCTCCCTTGCTGAA	0.517000													51	110					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145015920	145015920	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:145015920G>A	ENST00000369359.4	-	3	419	c.381C>T	c.(379-381)tcC>tcT	p.S127S	PDE4DIP_ENST00000530740.1_Silent_p.S127S|PDE4DIP_ENST00000493130.2_Silent_p.S56S|PDE4DIP_ENST00000478649.2_Silent_p.S56S|PDE4DIP_ENST00000313382.9_Silent_p.S56S|PDE4DIP_ENST00000369348.3_Silent_p.S127S			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATGCTCTCAAGGAATATGTCT	0.453000			T	PDGFRB	MPD								67	1189					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197122600	197122600	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:197122600C>T	ENST00000260983.2	-	18	3548	c.3366G>A	c.(3364-3366)ggG>ggA	p.G1122G	HECW2_ENST00000409111.1_Silent_p.G766G	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	1122					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						ATCCTGGAGTCCCTTCAGTTC	0.423000													19	72					0	0	1	0	0
RBL1	5933	broad.mit.edu	37	20	35684615	35684615	+	Missense_Mutation	SNP	C	C	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:35684615C>G	ENST00000373664.3	-	10	1363	c.1297G>C	c.(1297-1299)Gga>Cga	p.G433R	RBL1_ENST00000344359.3_Missense_Mutation_p.G433R	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	433	Domain A.|Pocket; binds T and E1A.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				TCTCCTATTCCTTTTAGTATT	0.348000													11	31					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139277831	139277831	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:139277831G>A	ENST00000298532.2	-	15	2158	c.1790C>T	c.(1789-1791)tCc>tTc	p.S597F		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	597					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		AGGGCTGAGGGAGGCAGCGGG	0.692000													7	19					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92087052	92087052	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:92087052C>T	ENST00000298047.6	+	1	1791	c.1774C>T	c.(1774-1776)Cca>Tca	p.P592S	FAT3_ENST00000525166.1_Missense_Mutation_p.P442S|FAT3_ENST00000409404.2_Missense_Mutation_p.P592S|FAT3_ENST00000541502.1_Missense_Mutation_p.P592S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	592	Cadherin 6.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATATGACTTTCCAGTTGGTGG	0.398000										TCGA Ovarian(4;0.039)			12	36					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82644304	82644304	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:82644304C>T	ENST00000533655.1	+	6	2136	c.1924C>T	c.(1924-1926)Cca>Tca	p.P642S	C11orf82_ENST00000430323.2_Missense_Mutation_p.P642S|C11orf82_ENST00000528759.1_3'UTR|C11orf82_ENST00000329143.3_Missense_Mutation_p.P341S|C11orf82_ENST00000525361.1_Intron	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	642					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TTGCAATAGTCCAAATAGAAG	0.333000													36	114					0	0	1	0	0
OR10H4	126541	broad.mit.edu	37	19	16060671	16060671	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:16060671C>T	ENST00000322107.1	+	1	854	c.854C>T	c.(853-855)cCc>cTc	p.P285L		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						GTCTTCACCCCCTTCCTTAGC	0.453000													52	169					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241991497	241991497	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:241991497G>A	ENST00000310397.8	+	14	1892	c.1892G>A	c.(1891-1893)gGc>gAc	p.G631D	SNED1_ENST00000469006.1_3'UTR|SNED1_ENST00000405547.3_Missense_Mutation_p.G631D|SNED1_ENST00000401884.1_Missense_Mutation_p.G631D|SNED1_ENST00000342631.6_Missense_Mutation_p.G631D|AC005237.4_ENST00000458377.1_RNA	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	631	EGF-like 9.				cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		TGTCACAACGGCGGCACCTGC	0.622000													26	49					0	0	1	0	0
PFKP	5214	broad.mit.edu	37	10	3151552	3151552	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:3151552C>T	ENST00000381075.2	+	12	1169	c.945C>T	c.(943-945)agC>agT	p.S315S	PFKP_ENST00000381125.4_Silent_p.S323S	NM_001242339.1	NP_001229268.1	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	323					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		TCCAGGCCAGCCGCATGGGAG	0.642000													29	50					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96131409	96131409	+	RNA	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:96131409G>A	ENST00000467865.1	+	0	1817				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		GGATGCATGGGGAAGGTGAGG	0.562000			T	TRA@	T-ALL								6	22					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120876451	120876451	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:120876451C>T	ENST00000273666.6	+	9	1125	c.854C>T	c.(853-855)cCt>cTt	p.P285L	STXBP5L_ENST00000492541.1_Missense_Mutation_p.P285L|STXBP5L_ENST00000497029.1_Missense_Mutation_p.P285L|STXBP5L_ENST00000472879.1_Missense_Mutation_p.P285L|STXBP5L_ENST00000471454.1_Missense_Mutation_p.P285L	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	285					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CCAAGTCGCCCTTTCCAGACC	0.408000													30	91					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49668497	49668497	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:49668497C>T	ENST00000339139.4	-	5	303	c.66_splice	c.e5-1	p.D23_splice		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	23						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAAGCGGGATCCTAAAAGAAA	0.318000													35	112					0	0	1	0	0
FCER1A	2205	broad.mit.edu	37	1	159277710	159277710	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:159277710C>T	ENST00000368115.1	+	6	861	c.762C>T	c.(760-762)ccC>ccT	p.P254P	FCER1A_ENST00000368114.1_Silent_p.P221P	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	254						integral to plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	AGCCAAACCCCAAAAACAACT	0.368000													17	70					0	0	1	0	0
NOP2	4839	broad.mit.edu	37	12	6672804	6672804	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:6672804G>A	ENST00000541778.1	-	7	1140	c.652C>T	c.(652-654)Ccc>Tcc	p.P218S	NOP2_ENST00000399466.2_Missense_Mutation_p.P218S|NOP2_ENST00000542015.1_Intron|NOP2_ENST00000537442.1_Missense_Mutation_p.P222S|NOP2_ENST00000545200.1_Missense_Mutation_p.P218S|NOP2_ENST00000322166.5_Missense_Mutation_p.P222S|NOP2_ENST00000382421.3_Missense_Mutation_p.P255S			P46087	NOP2_HUMAN	NOP2 nucleolar protein	222					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	19						CCAGCAGGGGGCAGCACAAAT	0.562000											OREG0021630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	41					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29627133	29627133	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:29627133G>A	ENST00000376894.4	+	2	244	c.126G>A	c.(124-126)cgG>cgA	p.R42R	MOG_ENST00000376917.3_Silent_p.R42R|MOG_ENST00000533330.2_Silent_p.R42R|MOG_ENST00000494692.1_Silent_p.R42R|MOG_ENST00000490427.1_Intron|MOG_ENST00000431798.2_Silent_p.R42R|MOG_ENST00000483013.1_Intron|MOG_ENST00000376891.4_Silent_p.R42R|MOG_ENST00000376888.2_Intron|MOG_ENST00000376902.3_Silent_p.R42R|MOG_ENST00000416766.2_Silent_p.R42R|MOG_ENST00000469603.1_3'UTR|MOG_ENST00000396701.2_Silent_p.R42R|MOG_ENST00000396704.3_Silent_p.R42R|MOG_ENST00000376898.3_Silent_p.R42R			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	42	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						ACCCTATCCGGGCTCTGGTCG	0.557000													73	261					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													4	31					0	0	1	0	0
RBL1	5933	broad.mit.edu	37	20	35684614	35684614	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:35684614C>T	ENST00000373664.3	-	10	1364	c.1298G>A	c.(1297-1299)gGa>gAa	p.G433E	RBL1_ENST00000344359.3_Missense_Mutation_p.G433E	NM_002895.2	NP_002886.2	P28749	RBL1_HUMAN	retinoblastoma-like 1 (p107)	433	Domain A.|Pocket; binds T and E1A.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			NS(1)|breast(1)|endometrium(7)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	42		Myeloproliferative disorder(115;0.00878)				CTCTCCTATTCCTTTTAGTAT	0.348000													11	30					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41806783	41806783	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:41806783G>A	ENST00000396930.3	-	11	2240	c.1697C>T	c.(1696-1698)cCt>cTt	p.P566L	KAT6A_ENST00000265713.2_Missense_Mutation_p.P566L|KAT6A_ENST00000485568.1_Missense_Mutation_p.P566L|KAT6A_ENST00000406337.1_Missense_Mutation_p.P566L	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	566	Catalytic.|Interaction with RUNX1-1.|Mediates interaction with BRPF1, required for histone H3 acetyltransferase activity.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										CTCATTGGCAGGAGGATGGAA	0.363000													11	19					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21897442	21897442	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:21897442G>A	ENST00000399982.2	-	2	960	c.896C>T	c.(895-897)cCc>cTc	p.P299L	CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Missense_Mutation_p.P20L|CHD8_ENST00000557364.1_Missense_Mutation_p.P299L	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	299	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ATGTCCTTGGGGACCTCCAGA	0.512000													20	39					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13737499	13737499	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:13737499C>T	ENST00000265104.4	-	66	11421	c.11317G>A	c.(11317-11319)Ggg>Agg	p.G3773R		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3773	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ACCAGGGACCCCTGGGTACTT	0.443000									Kartagener syndrome				48	141					0	0	1	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141034147	141034147	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:141034147G>C	ENST00000389328.4	-	18	2894	c.2880C>G	c.(2878-2880)taC>taG	p.Y960*	TRAPPC9_ENST00000389327.3_Nonsense_Mutation_p.Y853*|TRAPPC9_ENST00000438773.2_Nonsense_Mutation_p.Y862*	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	862					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GGCCTCCAGAGTATTTGAAAT	0.458000													29	152					0	0	1	0	0
RPP14	11102	broad.mit.edu	37	3	58303203	58303203	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:58303203A>G	ENST00000445193.2	+	6	766	c.355A>G	c.(355-357)Agg>Ggg	p.R119G	RPP14_ENST00000295959.5_Missense_Mutation_p.R119G|RPP14_ENST00000477305.1_3'UTR|RPP14_ENST00000466547.1_Missense_Mutation_p.R119G|RPP14_ENST00000544156.1_5'UTR	NM_001098783.2	NP_001092253.1	O95059	RPP14_HUMAN	ribonuclease P/MRP 14kDa subunit	119					tRNA processing	nucleus	identical protein binding|ribonuclease P activity|RNA binding			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.000187)|KIRC - Kidney renal clear cell carcinoma(10;0.0102)|Kidney(10;0.0118)|OV - Ovarian serous cystadenocarcinoma(275;0.191)		TGGTAATAGTAGGGAACTAGT	0.393000													21	55					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922887	24922887	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:24922887C>T	ENST00000329468.2	+	1	2347	c.1873C>T	c.(1873-1875)Cca>Tca	p.P625S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		ATCCCCACTTCCATTTATATT	0.493000													54	139					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156760448	156760448	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:156760448C>T	ENST00000347377.6	+	21	2810	c.2379C>T	c.(2377-2379)tcC>tcT	p.S793S	CYFIP2_ENST00000435847.2_Silent_p.S492S|CYFIP2_ENST00000377576.3_Silent_p.S793S|CYFIP2_ENST00000318218.6_Silent_p.S818S|CYFIP2_ENST00000442283.2_Silent_p.S78S|CYFIP2_ENST00000541131.1_Silent_p.S718S|CYFIP2_ENST00000522463.1_Silent_p.S597S|CYFIP2_ENST00000521420.1_Silent_p.S767S	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	818					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACCTGACCTCCATTGTGGTAA	0.498000													72	194					0	0	1	0	0
CYP2A13	1553	broad.mit.edu	37	19	41600878	41600878	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:41600878C>T	ENST00000330436.3	+	8	1176	c.1176C>T	c.(1174-1176)ttC>ttT	p.F392F		NM_000766.4	NP_000757.2	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 13	392					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			breast(3)|endometrium(6)|kidney(4)|large_intestine(8)|lung(13)|ovary(3)|prostate(3)|skin(2)	42					Clomipramine(DB01242)|Nicotine(DB00184)	CTGAAGTGTTCCCTATGCTGG	0.572000													49	148					0	0	1	0	0
IL18	3606	broad.mit.edu	37	11	112020877	112020877	+	Silent	SNP	T	T	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:112020877T>A	ENST00000280357.7	-	4	363	c.144A>T	c.(142-144)atA>atT	p.I48I	IL18_ENST00000533858.1_5'UTR|IL18_ENST00000524595.1_Silent_p.I44I|SDHD_ENST00000532699.1_Intron|IL18_ENST00000528832.1_Silent_p.I48I	NM_001562.3	NP_001553.1	Q14116	IL18_HUMAN	interleukin 18 (interferon-gamma-inducing factor)	48					angiogenesis|cell-cell signaling|chemokine biosynthetic process|granulocyte macrophage colony-stimulating factor biosynthetic process|interferon-gamma biosynthetic process|interleukin-13 biosynthetic process|interleukin-2 biosynthetic process|positive regulation of activated T cell proliferation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-17 production|positive regulation of natural killer cell proliferation|positive regulation of NK T cell proliferation|regulation of cell adhesion|sleep|T-helper 1 type immune response|type 2 immune response	cytosol|extracellular space	cytokine activity|signal transducer activity						all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;6.72e-07)|Epithelial(105;8.15e-07)|all cancers(92;1.43e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.055)		TCAAATTTCTTATGACTGATA	0.303000													19	74					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27861295	27861295	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:27861295C>T	ENST00000261716.3	+	19	3040	c.2521C>T	c.(2521-2523)Cgg>Tgg	p.R841W	TAOK1_ENST00000536202.1_Missense_Mutation_p.R693W	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	841					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			GGTCTCCCTCCGGAGGGCACT	0.408000													20	41					0	0	1	0	0
CXADR	1525	broad.mit.edu	37	21	18937831	18937831	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:18937831C>T	ENST00000284878.7	+	7	1667	c.919C>T	c.(919-921)Cct>Tct	p.P307S	CXADR_ENST00000306618.10_Missense_Mutation_p.P266S|CXADR_ENST00000400166.1_Silent_p.L219L|CXADR_ENST00000400165.1_Silent_p.L167L|CXADR_ENST00000400169.1_Missense_Mutation_p.P307S	NM_001338.4	NP_001329.1	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	307					blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(1)|prostate(2)	11				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		GTCCATGTCTCCTTCCAACAT	0.498000													16	67					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57170030	57170030	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:57170030C>T	ENST00000371244.4	+	7	1241	c.1175C>T	c.(1174-1176)cCc>cTc	p.P392L		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	392					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						ACGACTAAGCCCAAATCTTTA	0.468000													30	92					0	0	1	0	0
HTRA4	203100	broad.mit.edu	37	8	38845590	38845590	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:38845590G>A	ENST00000302495.4	+	9	1504	c.1404G>A	c.(1402-1404)ctG>ctA	p.L468L		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	468	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			ATTTGCTCCTGACAGTCATAC	0.338000													12	30					0	0	1	0	0
TUBB3	10381	broad.mit.edu	37	16	89999894	89999894	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:89999894G>A	ENST00000556922.1	+	4	1320	c.1226G>A	c.(1225-1227)cGa>cAa	p.R409Q	TUBB3_ENST00000304984.5_5'UTR|TUBB3_ENST00000555576.1_Missense_Mutation_p.R62Q|TUBB3_ENST00000554444.1_5'UTR|TUBB3_ENST00000315491.7_Missense_Mutation_p.R62Q|TUBB3_ENST00000553967.1_Missense_Mutation_p.R62Q|TUBB3_ENST00000554336.1_Missense_Mutation_p.R62Q			Q13509	TBB3_HUMAN	tubulin, beta 3 class III	62					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		TACGTGCCTCGAGCCATTCTG	0.567000													146	325					0	0	1	0	0
LINGO4	339398	broad.mit.edu	37	1	151774899	151774899	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:151774899G>A	ENST00000368820.3	-	2	1219	c.282C>T	c.(280-282)aaC>aaT	p.N94N		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	94						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTGAGAGCTGGTTGTAGCTGA	0.617000													42	63					0	0	1	0	0
ZNF653	115950	broad.mit.edu	37	19	11594518	11594518	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:11594518G>A	ENST00000293771.5	-	9	1963	c.1827C>T	c.(1825-1827)caC>caT	p.H609H	CTC-398G3.6_ENST00000585656.1_Intron	NM_138783.3	NP_620138.2	Q96CK0	ZN653_HUMAN	zinc finger protein 653	609					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	17						TGTGATCCGGGTGGCTTTTGA	0.622000													15	57					0	0	1	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92826893	92826893	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:92826893G>A	ENST00000394468.2	-	5	1120	c.1043C>T	c.(1042-1044)tCa>tTa	p.S348L	HEPACAM2_ENST00000453812.2_Missense_Mutation_p.S371L|HEPACAM2_ENST00000341723.4_Missense_Mutation_p.S336L|HEPACAM2_ENST00000492616.1_5'UTR|HEPACAM2_ENST00000440868.1_Missense_Mutation_p.S336L	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	348						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						AGGTGACAATGATTTTCCTTT	0.313000													16	63					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123258026	123258026	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:123258026C>T	ENST00000358487.5	-	12	1927	c.1655G>A	c.(1654-1656)gGa>gAa	p.G552E	FGFR2_ENST00000369059.1_Missense_Mutation_p.G438E|FGFR2_ENST00000369061.4_Missense_Mutation_p.G440E|FGFR2_ENST00000351936.6_Missense_Mutation_p.G550E|FGFR2_ENST00000346997.2_Missense_Mutation_p.G550E|FGFR2_ENST00000369060.4_Missense_Mutation_p.G436E|FGFR2_ENST00000357555.5_Missense_Mutation_p.G463E|FGFR2_ENST00000356226.4_Missense_Mutation_p.G435E|FGFR2_ENST00000369056.1_Missense_Mutation_p.G553E|FGFR2_ENST00000457416.2_Missense_Mutation_p.G553E|FGFR2_ENST00000360144.3_Missense_Mutation_p.G464E|FGFR2_ENST00000478859.1_Missense_Mutation_p.G324E	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	552	Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TGTGCAGGCTCCAAGAAGATT	0.423000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				25	39					0	0	1	0	0
ALDH3B1	221	broad.mit.edu	37	11	67786692	67786692	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:67786692C>T	ENST00000539229.1	+	6	561	c.445C>T	c.(445-447)Ctg>Ttg	p.L149L	ALDH3B1_ENST00000316367.6_Silent_p.L149L|ALDH3B1_ENST00000007633.8_Silent_p.L149L|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000342456.6_Silent_p.L113L	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	150					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	CGAGAAGATCCTGGCCGAGGT	0.637000													3	32					0	0	1	0	0
GLDC	2731	broad.mit.edu	37	9	6620311	6620311	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:6620311C>T	ENST00000321612.6	-	3	493	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	115					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GCAAGGATTTCATTTTCACCT	0.368000													28	89					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69536220	69536220	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:69536220C>T	ENST00000338206.5	-	1	126	c.117G>A	c.(115-117)atG>atA	p.M39I		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	39					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.M39I(1)									GGATTGTCTTCATATTTATCC	0.448000													158	433					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28575527	28575527	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:28575527C>T	ENST00000220562.4	+	3	2853	c.1951C>T	c.(1951-1953)Cag>Tag	p.Q651*	EXTL3_ENST00000523149.1_Nonsense_Mutation_p.Q267*|EXTL3_ENST00000519886.1_Intron	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	651						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CAAGGAATTTCAGGCAGCGCT	0.542000													31	93					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183675624	183675624	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:183675624C>T	ENST00000511685.1	+	22	4227	c.4104C>T	c.(4102-4104)atC>atT	p.I1368I	TENM3_ENST00000406950.2_Silent_p.I1368I|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		TTTTACAGATCACTGAAAATC	0.468000													10	25					0	0	1	0	0
TULP1	7287	broad.mit.edu	37	6	35473545	35473545	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:35473545C>T	ENST00000229771.6	-	11	1164	c.1085G>A	c.(1084-1086)gGa>gAa	p.G362E	TULP1_ENST00000322263.4_Missense_Mutation_p.G309E	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	362					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						ATTCTCCCCTCCTCGGGACAG	0.577000													13	55					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095143	69095143	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:69095143C>T	ENST00000332644.5	-	8	939	c.778G>A	c.(778-780)Gaa>Aaa	p.E260K		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	260	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						CTATAATTTTCATGAAAAATA	0.348000													17	77					0	0	1	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114079378	114079378	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:114079378C>T	ENST00000356501.4	-	5	692	c.517G>A	c.(517-519)Gag>Aag	p.E173K	ADPRHL1_ENST00000375418.3_Missense_Mutation_p.E255K	NM_199162.1	NP_954631.1	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	255					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			TTTTCCCTCTCTTCTGCATCA	0.448000													38	140					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615714	179615714	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179615714C>T	ENST00000360870.5	-	46	11635	c.11413G>A	c.(11413-11415)Gaa>Aaa	p.E3805K	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9642							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCTTATTTCAGTCTGGAAA	0.348000													55	177					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158369190	158369190	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:158369190C>T	ENST00000334438.1	-	1	66	c.67G>A	c.(67-69)Gag>Aag	p.E23K		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					AGCTGGAGCTCCCCCAGGCTG	0.473000													12	89					0	0	1	0	0
DYTN	391475	broad.mit.edu	37	2	207583000	207583000	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:207583000C>T	ENST00000452335.2	-	1	120	c.4G>A	c.(4-6)Gat>Aat	p.D2N		NM_001093730.1	NP_001087199.1	A2CJ06	DYTN_HUMAN	dystrotelin	2						plasma membrane	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(24)|ovary(1)|upper_aerodigestive_tract(1)	36				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TTATCTGGATCCATTTCACAA	0.373000													7	28					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23884359	23884359	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:23884359G>T	ENST00000355349.3	-	37	5566	c.5404C>A	c.(5404-5406)Cag>Aag	p.Q1802K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1802					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AGGGCGATCTGCTCGGCTTCG	0.617000													56	144					1.48341e-19	1.51672e-19	1	1	0
ZNF142	7701	broad.mit.edu	37	2	219508510	219508510	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:219508510G>A	ENST00000411696.2	-	7	3508	c.2729C>T	c.(2728-2730)cCt>cTt	p.P910L	ZNF142_ENST00000449707.1_Missense_Mutation_p.P910L			P52746	ZN142_HUMAN	zinc finger protein 142	910					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TGGGAGCACAGGTTGCAGAGG	0.557000													78	230					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6302764	6302764	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:6302764C>T	ENST00000226760.1	+	8	1412	c.1242C>T	c.(1240-1242)ttC>ttT	p.F414F	WFS1_ENST00000503569.1_Silent_p.F414F	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	414			Missing (in WFS).		endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		CTGTCTTCTTCGTCATCTTCT	0.592000													77	215					0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	55999780	55999780	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:55999780G>A	ENST00000313264.4	-	1	957	c.882C>T	c.(880-882)atC>atT	p.I294I		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					ACATGAAGAGGATTGTCCCAT	0.433000													62	158					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984123	41984123	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:41984123G>A	ENST00000333141.5	+	1	411	c.314G>A	c.(313-315)cGa>cAa	p.R105Q		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	105								p.R105Q(1)		breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						ATCAGCCTGCGAACTCTGAAG	0.547000													26	83					0	0	1	0	0
TMUB2	79089	broad.mit.edu	37	17	42266514	42266514	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:42266514C>T	ENST00000319511.6	+	2	750	c.100C>T	c.(100-102)Ctc>Ttc	p.L34F	TMUB2_ENST00000590235.1_Missense_Mutation_p.L34F|TMUB2_ENST00000592825.1_Missense_Mutation_p.L34F|TMUB2_ENST00000587172.1_Missense_Mutation_p.L34F|TMUB2_ENST00000587989.1_Missense_Mutation_p.L54F|TMUB2_ENST00000357984.3_Missense_Mutation_p.L34F|TMUB2_ENST00000538716.2_Missense_Mutation_p.L54F|TMUB2_ENST00000589184.1_Intron|TMUB2_ENST00000589785.1_Missense_Mutation_p.L34F|TMUB2_ENST00000446571.3_Missense_Mutation_p.L34F|TMUB2_ENST00000589856.1_Missense_Mutation_p.L34F	NM_177441.2	NP_803190.2	Q71RG4	TMUB2_HUMAN	transmembrane and ubiquitin-like domain containing 2	54						integral to membrane				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)	8		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CCTAGCTTGGCTCTCTACCTA	0.577000													40	126					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142481789	142481789	+	RNA	SNP	T	T	C	rs140267598	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:142481789T>C	ENST00000603901.1	+	0	468					NR_001296.3																						ACTACCCAGATGAGCTGCAGT	0.488000													3	28					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558982	140558982	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:140558982C>T	ENST00000239444.2	+	1	1612	c.1367C>T	c.(1366-1368)tCc>tTc	p.S456F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		456					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.S456F(1)		NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCCAAACCTCCTACACCCTG	0.607000													68	410					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132999853	132999853	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:132999853G>A	ENST00000254624.5	+	18	2194	c.1969G>A	c.(1969-1971)Gat>Aat	p.D657N	EFR3A_ENST00000519656.1_Missense_Mutation_p.D621N|EFR3A_ENST00000334503.4_Missense_Mutation_p.D657N	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	657						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			GCATGAAAAAGATTTGTACTT	0.358000													15	17					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53344960	53344960	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:53344960G>A	ENST00000595646.1	-	4	707	c.587C>T	c.(586-588)tCc>tTc	p.S196F	ZNF468_ENST00000396409.4_Missense_Mutation_p.S143F|ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Missense_Mutation_p.S143F|ZNF28_ENST00000594602.1_Intron			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		AGAATGGAGGGAATTATTTCC	0.353000													47	165					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	73000566	73000566	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:73000566G>A	ENST00000322038.5	+	2	3653	c.3069G>A	c.(3067-3069)ctG>ctA	p.L1023L	TSHZ1_ENST00000580243.1_Silent_p.L1068L	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	1068						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		AGGACCACCTGATCTATGTGA	0.537000													33	101					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55139376	55139376	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:55139376C>T	ENST00000414150.2	+	9	1976	c.1698C>T	c.(1696-1698)gcC>gcT	p.A566A	MROH7_ENST00000421030.2_Silent_p.A566A|MROH7_ENST00000454855.2_Silent_p.A84A|MROH7_ENST00000395690.2_Silent_p.A566A|MROH7_ENST00000409996.1_Silent_p.A134A|MROH7_ENST00000339553.5_Silent_p.A566A|MROH7_ENST00000545244.1_Silent_p.A134A					maestro heat-like repeat family member 7																		TCCCACAGGCCCTGGGGCCTT	0.552000													37	143					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433302	104433302	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:104433302G>A	ENST00000361820.3	-	3	1992	c.1392C>T	c.(1390-1392)ttC>ttT	p.F464F		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	464					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GATTCCAGATGAAAAAGTTGT	0.493000													75	230					0	0	1	0	0
SRSF7	6432	broad.mit.edu	37	2	38975790	38975790	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:38975790C>T	ENST00000313117.6	-	4	629	c.392G>A	c.(391-393)cGg>cAg	p.R131Q	SRSF7_ENST00000446327.2_Missense_Mutation_p.R131Q|SRSF7_ENST00000409276.1_Missense_Mutation_p.R131Q	NM_001031684.2|NM_001195446.1	NP_001026854.1|NP_001182375.1	Q16629	SRSF7_HUMAN	serine/arginine-rich splicing factor 7	131	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						TGATCTAGACCGTGACCTATT	0.408000													29	91					0	0	1	0	0
ELL2	22936	broad.mit.edu	37	5	95226815	95226815	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:95226815C>A	ENST00000237853.4	-	10	2102	c.1753G>T	c.(1753-1755)Gag>Tag	p.E585*	ELL2_ENST00000431061.2_Nonsense_Mutation_p.E335*	NM_012081.5	NP_036213.2	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	585					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	24		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		ACCTGATACTCTTTTGAGCCT	0.433000													69	210					2.18329e-32	2.25175e-32	1	1	0
CHAF1B	8208	broad.mit.edu	37	21	37766889	37766889	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:37766889G>A	ENST00000314103.4	+	5	573	c.422G>A	c.(421-423)gGg>gAg	p.G141E	CHAF1B_ENST00000480486.1_3'UTR	NM_005441.2	NP_005432.1	Q13112	CAF1B_HUMAN	chromatin assembly factor 1, subunit B (p60)	141					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|cytoplasm	chromatin binding|histone binding|unfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(2)	20						GCAACTGATGGGAATTTAATG	0.383000													56	168					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60937500	60937500	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:60937500C>T	ENST00000252999.3	-	2	472	c.406G>A	c.(406-408)Ggc>Agc	p.G136S	LAMA5_ENST00000370677.3_Missense_Mutation_p.G136S|LAMA5_ENST00000370692.3_Missense_Mutation_p.G136S	NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	136	Laminin N-terminal.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACTCCAGGCCGCGGGACAGC	0.647000													12	31					0	0	1	0	0
NCAM2	4685	broad.mit.edu	37	21	22790850	22790850	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:22790850A>T	ENST00000400546.1	+	11	1690	c.1441A>T	c.(1441-1443)Ata>Tta	p.I481L	NCAM2_ENST00000284894.7_Missense_Mutation_p.I339L	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	481	Ig-like C2-type 5.				neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CACTAATCATATAGGAACAAG	0.308000													54	153					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87780588	87780588	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:87780588G>A	ENST00000398204.4	+	20	1957	c.1634G>A	c.(1633-1635)gGa>gAa	p.G545E	ADAM22_ENST00000315984.7_Missense_Mutation_p.G545E|ADAM22_ENST00000398201.4_Missense_Mutation_p.G545E|ADAM22_ENST00000265727.7_Missense_Mutation_p.G545E|ADAM22_ENST00000398209.3_Missense_Mutation_p.G545E	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	545	Cys-rich.				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTTTGGAGGAAGATGCAAA	0.373000													20	79					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71508455	71508455	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:71508455G>A	ENST00000396073.3	+	9	1593	c.1312G>A	c.(1312-1314)Gag>Aag	p.E438K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	438					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AAATCCAAAGGAGAAGCCCCT	0.443000													18	109					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131404763	131404763	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:131404763G>A	ENST00000512055.1	-	10	2673	c.547C>T	c.(547-549)Cgt>Tgt	p.R183C	CPNE4_ENST00000512332.1_Missense_Mutation_p.R201C|CPNE4_ENST00000502818.1_Missense_Mutation_p.R201C|CPNE4_ENST00000429747.1_Missense_Mutation_p.R183C|CPNE4_ENST00000511604.1_Missense_Mutation_p.R183C			Q96A23	CPNE4_HUMAN	copine IV	183	C2 2.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						TCATTCATACGAAAAATTTCC	0.383000													13	36					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47172419	47172419	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:47172419C>T	ENST00000447411.1	-	10	1064	c.858G>A	c.(856-858)atG>atA	p.M286I	SLC38A4_ENST00000266579.4_Missense_Mutation_p.M286I	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	286					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					TGTAATCCATCATGAAGTTCA	0.453000													33	93					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459884	66459884	+	RNA	SNP	T	T	G	rs139166660	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:66459884T>G	ENST00000424345.1	+	0	144																											tagtagatgttcttcagtgtc	0.368000													6	17					0	0	1	0	0
TEX33	339669	broad.mit.edu	37	22	37398014	37398014	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr22:37398014C>T	ENST00000405091.2	-	4	604	c.353G>A	c.(352-354)gGg>gAg	p.G118E	TEX33_ENST00000381821.1_Missense_Mutation_p.G118E|TEX33_ENST00000402860.3_Missense_Mutation_p.G33E			O43247	EAN57_HUMAN	testis expressed 33	118																	GTCATCCGTCCCCTGGCATGG	0.622000													14	38					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94754846	94754846	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:94754846G>A	ENST00000554723.1	-	3	1307	c.889C>T	c.(889-891)Cac>Tac	p.H297Y	SERPINA10_ENST00000261994.4_Missense_Mutation_p.H257Y|SERPINA10_ENST00000393096.1_Missense_Mutation_p.H257Y|SERPINA10_ENST00000554173.1_Missense_Mutation_p.H257Y			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	257					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		TTGTCCAGGTGGAAAGTGTCG	0.453000													44	116					0	0	1	0	0
NLRC4	58484	broad.mit.edu	37	2	32476324	32476324	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:32476324G>A	ENST00000404025.2	-	5	1097	c.609C>T	c.(607-609)ctC>ctT	p.L203L	NLRC4_ENST00000360906.5_Silent_p.L203L|NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000402280.1_Silent_p.L203L			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	203	NACHT.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TGCTGAGACGGAGGAAGAAGA	0.527000													28	66					0	0	1	0	0
SLC17A5	26503	broad.mit.edu	37	6	74351534	74351534	+	Silent	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:74351534C>A	ENST00000355773.5	-	3	673	c.405G>T	c.(403-405)ggG>ggT	p.G135G	SLC17A5_ENST00000481996.1_5'UTR|SLC17A5_ENST00000393019.3_Silent_p.G135G	NM_012434.4	NP_036566.1	Q9NRA2	S17A5_HUMAN	solute carrier family 17 (acidic sugar transporter), member 5	135					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GCAGCATTTTCCCCCCTATTT	0.468000													70	104					4.98926e-31	5.12785e-31	1	1	0
FSHR	2492	broad.mit.edu	37	2	49381507	49381507	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:49381507C>T	ENST00000406846.2	-	1	169	c.50G>A	c.(49-51)gGa>gAa	p.G17E	FSHR_ENST00000304421.4_Missense_Mutation_p.G17E|FSHR_ENST00000346173.3_Missense_Mutation_p.G17E	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	17					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	ATGATGACATCCTGAGCCCAA	0.488000									Gonadal Dysgenesis, 46 XX				23	62					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169526008	169526008	+	Silent	SNP	C	C	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:169526008C>G	ENST00000367796.3	-	6	1029	c.828G>C	c.(826-828)ctG>ctC	p.L276L	F5_ENST00000367797.3_Silent_p.L276L|F5_ENST00000546081.1_Silent_p.L139L			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	276	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GGTTCTGCTCCAGGACCTGGC	0.498000													22	76					0	0	1	0	0
TAS2R14	50840	broad.mit.edu	37	12	11091671	11091671	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:11091671G>A	ENST00000537503.1	-	1	191	c.136C>T	c.(136-138)Cgg>Tgg	p.R46W	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_023922.1	NP_076411.1	Q9NYV8	T2R14_HUMAN	taste receptor, type 2, member 14	46					detection of chemical stimulus involved in sensory perception of bitter taste		bitter taste receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	8						GTGAGGATCCGATCAACCGAA	0.398000													9	56					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810767	7810767	+	Missense_Mutation	SNP	G	G	A	rs146082308		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:7810767G>A	ENST00000315599.7	-	4	407	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	CD209_ENST00000601256.1_Missense_Mutation_p.R105W|CD209_ENST00000315591.8_Missense_Mutation_p.R105W|CD209_ENST00000354397.6_Missense_Mutation_p.R129W|CD209_ENST00000601951.1_Missense_Mutation_p.R105W|CD209_ENST00000593821.1_Missense_Mutation_p.R85W|CD209_ENST00000394173.4_Intron|CD209_ENST00000602261.1_Missense_Mutation_p.R129W|CD209_ENST00000593660.1_Missense_Mutation_p.R105W|CD209_ENST00000394161.5_Intron|CD209_ENST00000301357.8_Missense_Mutation_p.R85W|CD209_ENST00000204801.8_Missense_Mutation_p.R85W	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	129	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.R129W(4)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCCTTCAGCCGGGTCAGCTCC	0.567000													5	283					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31605981	31605981	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:31605981C>T	ENST00000379416.3	-	11	972	c.924G>A	c.(922-924)gtG>gtA	p.V308V	XDH_ENST00000491727.1_5'UTR	NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	308	FAD-binding PCMH-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GGGTTTTTTCCACAATGCTCA	0.537000													34	47					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195492161	195492161	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:195492161C>T	ENST00000463781.3	-	9	14237	c.13778G>A	c.(13777-13779)cGa>cAa	p.R4593Q	MUC4_ENST00000346145.4_Missense_Mutation_p.R357Q|MUC4_ENST00000475231.1_Missense_Mutation_p.R4541Q|MUC4_ENST00000349607.4_Missense_Mutation_p.R306Q	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1350					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGTTGGAATCGTAAGTCCCG	0.652000													15	43					0	0	1	0	0
SUSD1	64420	broad.mit.edu	37	9	114842369	114842369	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:114842369C>T	ENST00000374270.3	-	11	1723	c.1551G>A	c.(1549-1551)atG>atA	p.M517I	SUSD1_ENST00000374264.2_Missense_Mutation_p.M517I|SUSD1_ENST00000374263.3_Missense_Mutation_p.M517I	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1	517						integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						ACATCTCCTCCATATCAGCTG	0.353000													21	72					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53907738	53907738	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:53907738C>T	ENST00000396328.1	-	15	2904	c.2665G>A	c.(2665-2667)Gaa>Aaa	p.E889K	WDR72_ENST00000557913.1_Missense_Mutation_p.E886K|WDR72_ENST00000360509.5_Missense_Mutation_p.E889K|WDR72_ENST00000559418.1_Missense_Mutation_p.E899K	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	889								p.E889*(1)		NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		CAATTATTTTCCAATCCTCTT	0.328000													25	65					0	0	1	0	0
FLCN	201163	broad.mit.edu	37	17	17131316	17131316	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:17131316C>T	ENST00000285071.4	-	4	590	c.136G>A	c.(136-138)Gaa>Aaa	p.E46K	RP11-45M22.4_ENST00000427497.3_Missense_Mutation_p.E46K|FLCN_ENST00000389169.5_Missense_Mutation_p.E46K	NM_144997.5	NP_659434.2	Q8NFG4	FLCN_HUMAN	folliculin	46					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|stomach(1)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TCCTCTTCTTCCGCCTGCTCA	0.652000									Familial Non-VHL Clear Cell Renal Cancer;Birt-Hogg-Dub syndrome				26	65					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7727273	7727273	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:7727273C>T	ENST00000572933.1	+	75	12911	c.11451C>T	c.(11449-11451)atC>atT	p.I3817I	DNAH2_ENST00000389173.2_Silent_p.I3817I			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3817	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCCGCTTCATCGAGCCGCCTG	0.597000													31	77					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52951089	52951089	+	Missense_Mutation	SNP	C	C	T	rs145325813		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:52951089C>T	ENST00000295213.4	+	11	1861	c.1487C>T	c.(1486-1488)tCg>tTg	p.S496L	SPATA18_ENST00000419395.2_Missense_Mutation_p.S464L	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	496					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AAGTGGAATTCGGTGCGATCT	0.398000													30	65					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	31066239	31066239	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:31066239C>T	ENST00000399914.1	-	2	783	c.262G>A	c.(262-264)Gat>Aat	p.D88N	GRIK1_ENST00000399907.1_Missense_Mutation_p.D88N|GRIK1_ENST00000327783.4_Missense_Mutation_p.D88N|GRIK1_ENST00000389124.2_Missense_Mutation_p.D88N|GRIK1_ENST00000535441.1_Missense_Mutation_p.D88N|GRIK1_ENST00000389125.3_Missense_Mutation_p.D88N|GRIK1_ENST00000472429.1_5'UTR|GRIK1_ENST00000309434.7_Missense_Mutation_p.D88N|GRIK1_ENST00000399913.1_Missense_Mutation_p.D88N|GRIK1_ENST00000399909.1_Missense_Mutation_p.D88N			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	88					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TCAAAACTATCAAAAAGGTTA	0.408000													43	104					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21124456	21124456	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:21124456C>A	ENST00000377122.4	-	14	1831	c.1435G>T	c.(1435-1437)Gag>Tag	p.E479*	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	479					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CTCGCTATCTCTGCAGCCTTC	0.423000													76	206					1.21826e-31	1.25428e-31	1	1	0
TTN	7273	broad.mit.edu	37	2	179611964	179611964	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179611964G>A	ENST00000360870.5	-	46	15385	c.15163C>T	c.(15163-15165)Cca>Tca	p.P5055S	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1162	Ig-like 31.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTCCCCTGGGGGTGTGGAG	0.498000													32	91					0	0	1	0	0
TMEM88	92162	broad.mit.edu	37	17	7758454	7758454	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:7758454C>T	ENST00000301599.6	+	1	72	c.62C>T	c.(61-63)cCc>cTc	p.P21L	TMEM88_ENST00000574668.1_Missense_Mutation_p.P21L	NM_203411.1	NP_981956.1	Q6PEY1	TMM88_HUMAN	transmembrane protein 88	21						integral to membrane				lung(1)	1		all_cancers(10;0.00528)|Prostate(122;0.202)				CCCCGGGACCCCCTGGACTGT	0.667000													7	24					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954695	30954695	+	Missense_Mutation	SNP	C	C	T	rs41288651	byFrequency	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:30954695C>T	ENST00000376296.3	+	2	984	c.743C>T	c.(742-744)cCc>cTc	p.P248L	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	248	28 X 15 AA approximate tandem repeats.|Ser-rich.			P -> V (in Ref. 3; AAQ88781 and 4; CAQ08321).		integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						TCCAGCACACCCTCCAGTGGG	0.642000													140	414					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36279258	36279258	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:36279258C>T	ENST00000007510.4	+	21	3935	c.3791C>T	c.(3790-3792)gCt>gTt	p.A1264V	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.A1100V|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.A1103V			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1264					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						GGGGAGGGGGCTGGTCCCCCA	0.677000													6	21					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	50971419	50971419	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:50971419G>A	ENST00000266037.9	+	5	249	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	76						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TAGGCAGTATGAAACTGTGGT	0.393000													7	20					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181693	57181693	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:57181693C>T	ENST00000504228.1	+	6	2130	c.2025C>T	c.(2023-2025)atC>atT	p.I675I	KIAA1211_ENST00000264229.6_Silent_p.I675I|KIAA1211_ENST00000541073.1_Silent_p.I668I			Q6ZU35	K1211_HUMAN	KIAA1211	675										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GGTCCAGAATCCTGAAGAACG	0.677000													38	117					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56487600	56487600	+	Missense_Mutation	SNP	T	T	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:56487600T>G	ENST00000291971.3	+	8	2878	c.2807T>G	c.(2806-2808)cTg>cGg	p.L936R	NLRP8_ENST00000590542.1_Missense_Mutation_p.L917R	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	936						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTTAATAGCCTGAAGGATGAT	0.463000													26	93					0	0	1	0	0
SPATA17	128153	broad.mit.edu	37	1	217947744	217947744	+	Silent	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:217947744A>G	ENST00000366933.4	+	7	643	c.588A>G	c.(586-588)gcA>gcG	p.A196A		NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	196						cytoplasm	calmodulin binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TACAGAAGGCAAAGCCTTTAA	0.433000													34	141					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773097	140773097	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:140773097C>T	ENST00000398604.2	+	1	717	c.717C>T	c.(715-717)gcC>gcT	p.A239A	PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACAATGCCCCGGTTTTTC	0.587000													34	136					0	0	1	0	0
ZNF765	91661	broad.mit.edu	37	19	53911911	53911911	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:53911911C>T	ENST00000396408.3	+	4	1220	c.1103C>T	c.(1102-1104)tCa>tTa	p.S368L	ZNF765_ENST00000594030.1_Intron	NM_001040185.1	NP_001035275.1	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(3)	4				GBM - Glioblastoma multiforme(134;0.00379)		AGTCGGAAGTCACATTTTACA	0.408000													61	170					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96698517	96698517	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:96698517A>T	ENST00000260682.6	+	1	90	c.78A>T	c.(76-78)agA>agT	p.R26S	CYP2C9_ENST00000461906.1_3'UTR	NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	26					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GCTCTGGGAGAGGAAAACTCC	0.458000													74	107					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278535	50278535	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:50278535G>A	ENST00000442544.2	+	2	819	c.203G>A	c.(202-204)gGa>gAa	p.G68E		NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	68	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCCGACCGAGGAGTTCCAGTG	0.512000													29	70					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26906079	26906079	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:26906079C>T	ENST00000231021.4	-	5	972	c.800G>A	c.(799-801)cGa>cAa	p.R267Q		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	267	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R267Q(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CTGGGGAAATCGAGGAGGGTT	0.428000													55	140					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140737079	140737079	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:140737079C>T	ENST00000571252.1	+	1	2312	c.2312C>T	c.(2311-2313)tCc>tTc	p.S771F	PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGATCTTCTCCCAACCCAGC	0.552000													31	131					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9730630	9730630	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:9730630C>T	ENST00000296003.4	+	16	1419	c.1297C>T	c.(1297-1299)Cga>Tga	p.R433*	MTMR14_ENST00000420925.1_Nonsense_Mutation_p.R187*|MTMR14_ENST00000353332.5_Nonsense_Mutation_p.R433*|MTMR14_ENST00000351233.5_Nonsense_Mutation_p.R433*	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	433						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					TCTTTTAGGACGAAAGGACCG	0.527000													23	86					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153221832	153221832	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:153221832G>A	ENST00000310441.7	-	16	3632	c.2666C>T	c.(2665-2667)aCc>aTc	p.T889I	HCFC1_ENST00000369984.4_Missense_Mutation_p.T889I|HCFC1_ENST00000354233.3_Missense_Mutation_p.T820I	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	889	Interaction with GABP2.|Interaction with ZBTB17.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGTGGAGACGGTGCCTGTCAC	0.642000													35	31					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128742	45128742	+	RNA	SNP	T	T	G	rs34655963	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:45128742T>G	ENST00000575173.1	-	0	418																											TAATGATTTTTATTATACTTT	0.328000													4	128					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247076605	247076605	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:247076605A>G	ENST00000366508.1	-	4	726	c.590T>C	c.(589-591)gTt>gCt	p.V197A	AHCTF1_ENST00000391829.2_Missense_Mutation_p.V162A|AHCTF1_ENST00000326225.3_Missense_Mutation_p.V171A			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	162	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GATCTGTCCAACATCAGTGAC	0.408000													18	98					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488111	24488111	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:24488111C>T	ENST00000264463.4	-	12	2535	c.2028G>A	c.(2026-2028)agG>agA	p.R676R	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	676					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CTGCAGGATTCCTCAGGGTGC	0.473000										HNSCC(23;0.051)			37	89					0	0	1	0	0
CABS1	85438	broad.mit.edu	37	4	71201127	71201127	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:71201127C>T	ENST00000273936.4	+	1	430	c.371C>T	c.(370-372)tCa>tTa	p.S124L		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	124						flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GGGAATATTTCATCACCAGTT	0.378000													29	73					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53612707	53612707	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:53612707G>A	ENST00000455735.2	-	7	1055	c.735C>T	c.(733-735)ttC>ttT	p.F245F	ZNF415_ENST00000243643.4_Silent_p.F197F|ZNF415_ENST00000421033.1_Silent_p.F209F|ZNF415_ENST00000597748.1_3'UTR|ZNF415_ENST00000601493.1_5'UTR|ZNF415_ENST00000595193.1_3'UTR|ZNF415_ENST00000440291.1_Silent_p.F184F|ZNF415_ENST00000500065.4_Silent_p.F197F|ZNF415_ENST00000597503.1_3'UTR|ZNF415_ENST00000448501.1_Silent_p.F245F|ZNF415_ENST00000594011.1_3'UTR			Q09FC8	ZN415_HUMAN	zinc finger protein 415	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		AAGAACAGATGAAATCAGTCC	0.378000													36	97					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13134686	13134686	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:13134686G>A	ENST00000399002.2	+	10	1590	c.1316G>A	c.(1315-1317)aGa>aAa	p.R439K	SPTLC3_ENST00000378194.4_3'UTR	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	439					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	AAAAACACAAGATACTTCAGA	0.438000													40	89					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934850	28934850	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:28934850G>A	ENST00000257192.4	+	15	2903	c.2691G>A	c.(2689-2691)agG>agA	p.R897R	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG1_ENST00000462981.2_Silent_p.R256R	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	897					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TGACAGAAAGGGTAATAGCAC	0.463000													72	171					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36017588	36017588	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:36017588A>C	ENST00000452271.2	-	1	1624	c.1596T>G	c.(1594-1596)aaT>aaG	p.N532K	SBSN_ENST00000518157.1_Missense_Mutation_p.N189K	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	189						extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GGTTGACCCCATTATGAGCAT	0.592000													41	147					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358395	10358395	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:10358395C>T	ENST00000255381.2	-	21	2409		c.e21-1		CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TGAAGAAAACCTTATGAAAGA	0.403000													34	109					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27320678	27320678	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:27320678G>A	ENST00000407991.1	-	6	1890	c.1282C>T	c.(1282-1284)Cat>Tat	p.H428Y	CHRNA2_ENST00000520933.2_Missense_Mutation_p.H428Y|CHRNA2_ENST00000240132.2_Missense_Mutation_p.H413Y	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	428						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GGGGCCACATGACCTGCACAT	0.647000													33	92					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57075434	57075434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:57075434C>T	ENST00000436936.1	+	18	3202	c.2977C>T	c.(2977-2979)Cag>Tag	p.Q993*	NLRC5_ENST00000539144.1_Nonsense_Mutation_p.Q993*|NLRC5_ENST00000308149.7_Nonsense_Mutation_p.Q993*|NLRC5_ENST00000262510.6_Nonsense_Mutation_p.Q993*			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	993					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GCACCTAGAGCAGCTCTGCAA	0.582000													14	60					0	0	1	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157784	65157784	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:65157784C>T	ENST00000323544.4	+	6	1298	c.1170C>T	c.(1168-1170)tcC>tcT	p.S390S	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	390										NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						GCTGCTCCTCCCTTGGGGACT	0.647000													28	62					0	0	1	0	0
HNF4A	3172	broad.mit.edu	37	20	43058294	43058294	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:43058294G>A	ENST00000316099.3	+	10	1503	c.1414G>A	c.(1414-1416)Gaa>Aaa	p.E472K	HNF4A_ENST00000457232.1_Missense_Mutation_p.E440K|HNF4A_ENST00000415691.1_Missense_Mutation_p.E462K	NM_000457.4|NM_001258355.1	NP_000448.3|NP_001245284.1	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4, alpha	472					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(4)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	34		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CACCAAGCAGGAAGTTATCTA	0.632000													54	167					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79181171	79181171	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:79181171G>A	ENST00000554719.1	+	5	1105	c.614G>A	c.(613-615)gGa>gAa	p.G205E	NRXN3_ENST00000335750.5_Missense_Mutation_p.G205E	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	211	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GACCTGGAAGGAGACATGTAC	0.592000													56	162					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31318201	31318201	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:31318201C>T	ENST00000380490.3	+	2	173	c.75C>T	c.(73-75)ttC>ttT	p.F25F	ALOX5AP_ENST00000479597.1_3'UTR	NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	25	Inhibitor binding.				cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding	p.F25L(1)		endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		TGGCAGGATTCTTTGCCCATA	0.493000													17	58					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30680869	30680869	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:30680869G>A	ENST00000376406.3	-	5	1497	c.850C>T	c.(850-852)Cca>Tca	p.P284S	MDC1_ENST00000376405.2_Missense_Mutation_p.P284S|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	284	Required for nuclear localization (NLS1).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						ACCCCAGCTGGAACCACCCCA	0.522000								Other conserved DNA damage response genes					49	138					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821654	5821654	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:5821654G>A	ENST00000381095.3	-	5	1692	c.1065C>T	c.(1063-1065)atC>atT	p.I355I	NLGN4X_ENST00000381092.1_Silent_p.I355I|NLGN4X_ENST00000275857.6_Silent_p.I355I|NLGN4X_ENST00000381093.2_Silent_p.I375I|NLGN4X_ENST00000538097.1_Silent_p.I355I	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	355					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						GCTCCATCAGGATCTGGGGGT	0.597000													28	28					0	0	1	0	0
PIH1D3	139212	broad.mit.edu	37	X	106482197	106482197	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:106482197G>A	ENST00000535523.1	+	7	812	c.475G>A	c.(475-477)Gat>Aat	p.D159N	PIH1D3_ENST00000372453.3_Missense_Mutation_p.D159N|PIH1D3_ENST00000336387.4_Missense_Mutation_p.D159N	NM_001169154.1	NP_001162625.1			PIH1 domain containing 3																		TATTCAAATTGATATCCAGGA	0.308000													17	37					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56058264	56058264	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:56058264G>A	ENST00000313022.2	-	1	302	c.275C>T	c.(274-276)tCc>tTc	p.S92F		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					GCCCATGAAGGAAATATAGTT	0.398000													113	359					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86196336	86196336	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:86196336G>A	ENST00000370571.2	-	60	5404	c.5038C>T	c.(5038-5040)Cac>Tac	p.H1680Y	COL24A1_ENST00000436319.1_Missense_Mutation_p.H1659Y	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1680	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCCTGGGTGTGAAAAAGAAAT	0.368000													32	105					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740711	37740711	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:37740711G>A	ENST00000539465.1	+	15	2779	c.2186G>A	c.(2185-2187)cGg>cAg	p.R729Q	FRMPD1_ENST00000541302.1_Missense_Mutation_p.R598Q|FRMPD1_ENST00000536622.1_Missense_Mutation_p.R551Q|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Missense_Mutation_p.R729Q			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	729						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		ACAGCTTCCCGGCAAGGGGGA	0.647000													16	53					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1250535	1250535	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:1250535C>T	ENST00000348261.5	+	7	1331	c.1083C>T	c.(1081-1083)ttC>ttT	p.F361F	CACNA1H_ENST00000565831.1_Silent_p.F361F|CACNA1H_ENST00000358590.4_Silent_p.F361F	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	361					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCATCAACTTCGACAACATCG	0.647000													26	81					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5430102	5430102	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:5430102G>A	ENST00000399434.2	-	3	437	c.279C>T	c.(277-279)gtC>gtT	p.V93V	TNRC18_ENST00000399537.4_Intron|TNRC18_ENST00000430969.1_Intron			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	0							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CCCAACCCCGGACTCCAGTCT	0.622000													7	56					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847548	123847548	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:123847548C>A	ENST00000531945.1	-	1	940	c.851G>T	c.(850-852)gGg>gTg	p.G284V		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AGCAGGGGCCCCAGCTCCTGC	0.557000													47	151					3.50607e-19	3.57861e-19	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11795111	11795111	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:11795111C>T	ENST00000262442.3	+	58	11198	c.11130C>T	c.(11128-11130)ttC>ttT	p.F3710F	DNAH9_ENST00000396001.2_Silent_p.F22F|DNAH9_ENST00000454412.2_Silent_p.F3710F	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3710					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTATCGTCTTCCAGAAGGCTG	0.517000													53	143					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48459866	48459866	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:48459866C>T	ENST00000358536.4	-	14	3310	c.3041G>A	c.(3040-3042)gGg>gAg	p.G1014E	PLXNB1_ENST00000358459.4_Missense_Mutation_p.G831E|PLXNB1_ENST00000296440.6_Missense_Mutation_p.G1014E|PLXNB1_ENST00000456774.1_Missense_Mutation_p.G831E|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1014					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACCATGCAGCCCCTCAGCACT	0.667000													15	36					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150647238	150647238	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:150647238C>T	ENST00000430723.3	-	9	2428	c.2416G>A	c.(2416-2418)Ggc>Agc	p.G806S	KCNH2_ENST00000392968.2_Intron|KCNH2_ENST00000262186.5_Intron|KCNH2_ENST00000330883.4_Intron	NM_172056.2	NP_742053.1	Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	0					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	AGTCCAGTGCCCGCCCCCCAC	0.647000													51	45					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128392735	128392735	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:128392735G>A	ENST00000389524.4	+	42	5732	c.5679G>A	c.(5677-5679)cgG>cgA	p.R1893R	MYO7B_ENST00000409090.1_Silent_p.R745R|MYO7B_ENST00000409816.2_Silent_p.R1892R|MYO7B_ENST00000428314.1_Silent_p.R1892R			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1892	FERM 2.|MyTH4 3.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACTTCATGCGGAAATTGTGGC	0.627000													8	25					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127469919	127469919	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:127469919C>T	ENST00000262461.2	+	6	1440	c.1251C>T	c.(1249-1251)gtC>gtT	p.V417V	SLC12A2_ENST00000343225.4_Silent_p.V417V	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	417					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	CCATTACAGTCGTGATTCTTT	0.323000													56	161					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604270	179604270	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179604270C>T	ENST00000589042.1	-	48	13914	c.13690G>A	c.(13690-13692)Gaa>Aaa	p.E4564K	TTN_ENST00000359218.5_Missense_Mutation_p.E4326K|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E4393K|TTN_ENST00000591111.1_Missense_Mutation_p.E4247K|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.E4201K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4247	Ig-like 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTTGTTTTTCGTCAGAGACA	0.428000													33	82					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463723	25463723	+	RNA	SNP	T	T	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:25463723T>C	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						TACATCCGGGTTCCACTGGAT	0.552000													74	187					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88964547	88964547	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:88964547G>C	ENST00000333190.4	+	4	2860	c.2251G>C	c.(2251-2253)Gaa>Caa	p.E751Q		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	751						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CCACTCAGTTGAAAGGCACAA	0.403000										HNSCC(36;0.09)			16	62					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116397530	116397530	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:116397530C>T	ENST00000397752.3	+	7	2102	c.1902C>T	c.(1900-1902)ttC>ttT	p.F634F	MET_ENST00000436117.2_Silent_p.F634F|MET_ENST00000318493.6_Silent_p.F634F	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	634	IPT/TIG 1.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			ATAAGCATTTCAATATGTCCA	0.348000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				37	113					0	0	1	0	0
YTHDF3	253943	broad.mit.edu	37	8	64099080	64099080	+	Translation_Start_Site	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:64099080G>A	ENST00000542911.2	+	0	764				YTHDF3_ENST00000539294.1_Missense_Mutation_p.A170T|YTHDF3_ENST00000521674.1_3'UTR|YTHDF3_ENST00000517371.1_Intron			Q7Z739	YTHD3_HUMAN	YTH domain family, member 3													Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			TGATGGACAGGCTGGATTTGG	0.458000													11	43					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133789669	133789669	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:133789669C>T	ENST00000321016.8	-	18	4181	c.3951G>A	c.(3949-3951)ccG>ccA	p.P1317P	IGSF9B_ENST00000533871.2_Silent_p.P1317P			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1317	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GTGGGGTCTCCGGTCGGAGCA	0.697000													5	20					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133244129	133244129	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:133244129G>A	ENST00000320574.5	-	20	2322	c.2279C>T	c.(2278-2280)gCc>gTc	p.A760V	POLE_ENST00000535270.1_Missense_Mutation_p.A733V	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	760					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTCCCGGAAGGCACGCACGGT	0.572000								DNA polymerases (catalytic subunits)					156	221					0	0	1	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32928527	32928527	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:32928527G>A	ENST00000361627.3	+	12	2275	c.1553G>A	c.(1552-1554)cGg>cAg	p.R518Q	ARHGAP11A_ENST00000565905.1_Missense_Mutation_p.R329Q|ARHGAP11A_ENST00000543522.1_Missense_Mutation_p.R329Q	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	518					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		ACAAATTACCGGATGTCTTGG	0.378000													35	91					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99662020	99662020	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:99662020C>T	ENST00000292450.4	+	4	1366	c.1202C>T	c.(1201-1203)gCg>gTg	p.A401V	ZNF3_ENST00000413658.2_3'UTR|ZSCAN21_ENST00000543588.1_Missense_Mutation_p.R367W|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.R367W	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	401					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AGTCAGCATGCGGGCCTCAGC	0.522000													4	173					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16001103	16001103	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:16001103C>T	ENST00000350896.3	-	8	1194	c.997G>A	c.(997-999)Ggc>Agc	p.G333S	MSR1_ENST00000262101.5_Missense_Mutation_p.G333S|MSR1_ENST00000381998.4_Missense_Mutation_p.G333S|MSR1_ENST00000355282.2_Missense_Mutation_p.G333S|MSR1_ENST00000445506.2_Missense_Mutation_p.G351S|MSR1_ENST00000536385.1_Missense_Mutation_p.G107S	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	369	Collagen-like.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCTTTCTGGCCTTTTGGTCCA	0.343000													27	55					0	0	1	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111624196	111624196	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:111624196G>A	ENST00000527614.1	-	9	1200	c.1135C>T	c.(1135-1137)Cct>Tct	p.P379S	PPP2R1B_ENST00000427203.2_Missense_Mutation_p.P218S|PPP2R1B_ENST00000426998.2_Missense_Mutation_p.P315S|PPP2R1B_ENST00000393055.2_Missense_Mutation_p.P252S|PPP2R1B_ENST00000341980.6_Intron|PPP2R1B_ENST00000311129.5_Missense_Mutation_p.P379S	NM_001177562.1|NM_002716.4	NP_001171033.1|NP_002707.3	P30154	2AAB_HUMAN	protein phosphatase 2, regulatory subunit A, beta	379							protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|liver(1)|lung(10)|prostate(1)|urinary_tract(2)	22		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		AAGAAAAGAGGTAGAAGATGT	0.353000													15	55					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196434428	196434428	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:196434428G>A	ENST00000451324.2	-	8	682	c.13C>T	c.(13-15)Cac>Tac	p.H5Y	KCNT2_ENST00000294725.8_Silent_p.F211F|KCNT2_ENST00000367433.5_Silent_p.F211F|KCNT2_ENST00000367431.4_Silent_p.F211F|KCNT2_ENST00000498426.1_5'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	0						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CTTACCAGGTGAAGATAAGGC	0.269000													47	75					0	0	1	0	0
FAM166B	730112	broad.mit.edu	37	9	35562962	35562962	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:35562962C>T	ENST00000399742.2	-	3	472	c.402G>A	c.(400-402)aaG>aaA	p.K134K	FAM166B_ENST00000492890.1_5'UTR	NM_001099951.2|NM_001164310.1	NP_001093421.1|NP_001157782.1	A8MTA8	F166B_HUMAN	family with sequence similarity 166, member B	134										kidney(3)|large_intestine(1)|lung(4)|ovary(1)	9						CCTTGGCCTCCTTTGGTAGCT	0.557000													26	66					0	0	1	0	0
CTHRC1	115908	broad.mit.edu	37	8	104388038	104388038	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:104388038C>T	ENST00000330295.5	+	2	365	c.223C>T	c.(223-225)Ccg>Tcg	p.P75S	CTHRC1_ENST00000520337.1_Missense_Mutation_p.P61S|CTHRC1_ENST00000415886.2_Missense_Mutation_p.P75S	NM_138455.3	NP_612464.1	Q96CG8	CTHR1_HUMAN	collagen triple helix repeat containing 1	75	Collagen-like.					collagen				endometrium(1)|large_intestine(5)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)			CAATGGCATTCCGGGTACACC	0.517000													44	212					0	0	1	0	0
SYT11	23208	broad.mit.edu	37	1	155838351	155838351	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:155838351G>A	ENST00000368324.4	+	2	883	c.630G>A	c.(628-630)gtG>gtA	p.V210V	SYT11_ENST00000539162.1_Intron	NM_152280.4	NP_689493.3	Q9BT88	SYT11_HUMAN	synaptotagmin XI	210	C2 1.					cell junction|synaptic vesicle membrane	protein binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			GGCATCGGGTGAAGACCAGAG	0.572000													27	132					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049631	107049631	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:107049631C>T	ENST00000409886.3	-	16	2403	c.2316G>A	c.(2314-2316)gcG>gcA	p.A772A	RGPD3_ENST00000304514.7_Silent_p.A772A	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	772					intracellular transport		binding	p.A772A(4)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTCTGAATCCGCATTTCGCA	0.373000													5	237					0	0	1	0	0
CACNG7	59284	broad.mit.edu	37	19	54444853	54444853	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:54444853C>T	ENST00000391767.1	+	5	766	c.554C>T	c.(553-555)tCc>tTc	p.S185F	CACNG7_ENST00000391766.1_Missense_Mutation_p.S185F|CACNG7_ENST00000222212.2_Missense_Mutation_p.S185F			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	185					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		GCCGCTTCCTCCTTCCTACTC	0.537000													69	149					0	0	1	0	0
TEAD3	7005	broad.mit.edu	37	6	35443834	35443834	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:35443834C>T	ENST00000338863.7	-	10	989	c.762G>A	c.(760-762)acG>acA	p.T254T	TEAD3_ENST00000402886.3_Silent_p.T194T	NM_003214.3	NP_003205.2	Q99594	TEAD3_HUMAN	TEA domain family member 3	254	Transcriptional activation (Potential).		T -> M (in dbSNP:rs35080860).		female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	10						AGGCGGGGTTCGTCTGGCCGA	0.587000													8	29					0	0	1	0	0
STK32A	202374	broad.mit.edu	37	5	146703479	146703479	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:146703479G>A	ENST00000397936.3	+	5	612	c.279G>A	c.(277-279)gaG>gaA	p.E93E	STK32A_ENST00000398521.3_Silent_p.E93E|STK32A_ENST00000541094.1_Silent_p.E93E|STK32A_ENST00000398523.3_Silent_p.E93E	NM_001112724.1	NP_001106195.1	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A	93	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAAGATGAGGAAGACATGT	0.423000													10	28					0	0	1	0	0
RBBP8	5932	broad.mit.edu	37	18	20573375	20573375	+	Missense_Mutation	SNP	C	C	T	rs148864984		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:20573375C>T	ENST00000399722.2	+	11	1936	c.1585C>T	c.(1585-1587)Cca>Tca	p.P529S	RBBP8_ENST00000399725.2_Missense_Mutation_p.P529S|RBBP8_ENST00000327155.5_Missense_Mutation_p.P529S|RBBP8_ENST00000360790.5_Missense_Mutation_p.P529S	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	529					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			GAAGACCATTCCAAAGGGCTT	0.463000								Homologous recombination					30	78					0	0	1	0	0
VPS18	57617	broad.mit.edu	37	15	41192876	41192876	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:41192876G>A	ENST00000220509.5	+	4	2199	c.1860G>A	c.(1858-1860)cgG>cgA	p.R620R	VPS18_ENST00000558474.1_Intron	NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	620					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		TGGGCAGCCGGCTGGATGCTC	0.607000													38	92					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073160	17073160	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr22:17073160C>T	ENST00000359963.3	-	1	540	c.281G>A	c.(280-282)gGa>gAa	p.G94E		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	94					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTGGGTTTGTCCTGCTTCCCG	0.617000													26	59					0	0	1	0	0
INSL6	11172	broad.mit.edu	37	9	5164230	5164230	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:5164230C>T	ENST00000381641.3	-	2	390	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	INSL6_ENST00000510407.1_5'UTR	NM_007179.2	NP_009110.2	Q9Y581	INSL6_HUMAN	insulin-like 6	109						extracellular region	hormone activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(2)	15	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		GACTGCATTTCCCAACTGTTT	0.318000													29	113					0	0	1	0	0
CYBB	1536	broad.mit.edu	37	X	37652981	37652981	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:37652981C>T	ENST00000378588.4	+	5	468	c.401C>T	c.(400-402)tCt>tTt	p.S134F	TM4SF2_ENST00000465127.1_Intron|CYBB_ENST00000545017.1_Missense_Mutation_p.S102F|CYBB_ENST00000536160.1_Intron	NM_000397.3	NP_000388.2	P04839	CY24B_HUMAN	cytochrome b-245, beta polypeptide	134	Ferric oxidoreductase.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|prostate(2)|skin(2)	32						GTCAATAATTCTGATCCTTAT	0.388000													43	35					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13700919	13700919	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:13700919G>A	ENST00000265104.4	-	78	13657	c.13553C>T	c.(13552-13554)aCc>aTc	p.T4518I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4518					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CATCCATTTGGTGACTTCATT	0.483000									Kartagener syndrome				52	152					0	0	1	0	0
ARHGEF4	50649	broad.mit.edu	37	2	131785584	131785584	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:131785584A>T	ENST00000392953.3	+	5	1013	c.494A>T	c.(493-495)tAt>tTt	p.Y165F	ARHGEF4_ENST00000326016.5_Missense_Mutation_p.Y165F|ARHGEF4_ENST00000355771.3_Missense_Mutation_p.Y94F|ARHGEF4_ENST00000525839.1_Missense_Mutation_p.Y165F|ARHGEF4_ENST00000428230.2_Intron|ARHGEF4_ENST00000409303.1_Missense_Mutation_p.Y165F	NM_032995.1	NP_127462.1	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor (GEF) 4	165					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(4)	29		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		GAGGACCTGTATGATGACCTG	0.632000													11	49					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26455081	26455081	+	Missense_Mutation	SNP	G	G	A	rs56403976		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:26455081G>A	ENST00000265944.5	+	27	3251	c.3085G>A	c.(3085-3087)Gat>Aat	p.D1029N	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1029	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AGCTGGTCTCGATAACTGGGC	0.403000													79	245					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919272	21919272	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:21919272G>A	ENST00000240662.2	-	3	1005	c.660C>T	c.(658-660)atC>atT	p.I220I	RP11-59N23.1_ENST00000542489.1_RNA	NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	220						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	AGGCACTAATGATCATGCTTT	0.498000													35	115					0	0	1	0	0
FAM58A	92002	broad.mit.edu	37	X	152858169	152858169	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:152858169G>A	ENST00000406277.2	-	6	548	c.446C>T	c.(445-447)tCc>tTc	p.S149F	FAM58A_ENST00000370175.4_5'UTR	NM_001130997.1|NM_152274.3	NP_001124469.1|NP_689487.2	Q8N1B3	FA58A_HUMAN	family with sequence similarity 58, member A	151					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTTCTGGAGGGAAACCAGGTA	0.612000													9	6					0	0	1	0	0
NMS	129521	broad.mit.edu	37	2	101099725	101099725	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:101099725G>A	ENST00000376865.1	+	10	468	c.461G>A	c.(460-462)tGa>tAa	p.*154*		NM_001011717.1	NP_001011717.1	Q5H8A3	NMS_HUMAN	neuromedin S	0					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				breast(1)|large_intestine(4)|lung(7)|ovary(1)|stomach(1)	14						ATTCAGTGGTGAAAGAAAGCT	0.348000													18	46					0	0	1	0	0
UTP11L	51118	broad.mit.edu	37	1	38478520	38478520	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:38478520C>T	ENST00000373014.4	+	1	107	c.46C>T	c.(46-48)Cac>Tac	p.H16Y	UTP11L_ENST00000537711.1_Missense_Mutation_p.H16Y	NM_016037.3	NP_057121.2	Q9Y3A2	UTP11_HUMAN	UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)	16					induction of apoptosis|nerve growth factor receptor signaling pathway|nervous system development|rRNA processing	cytoplasm|extracellular space|nucleolus|small-subunit processome	protein binding			NS(1)|cervix(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GCAGCGGGAACACAGAGAGCG	0.612000													56	170					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179609068	179609068	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:179609068G>A	ENST00000444136.1	+	10	1865	c.1615G>A	c.(1615-1617)Gat>Aat	p.D539N	TDRD5_ENST00000367614.1_Missense_Mutation_p.D539N|TDRD5_ENST00000294848.8_Missense_Mutation_p.D539N	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	539	Tudor.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						GATTTCTGAGGATAAGTGGTG	0.428000													190	223					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167983660	167983660	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:167983660C>T	ENST00000357154.3	-	4	364	c.227G>A	c.(226-228)gGa>gAa	p.G76E	SPOCK3_ENST00000357545.4_Missense_Mutation_p.G73E|SPOCK3_ENST00000512648.1_Missense_Mutation_p.G73E|SPOCK3_ENST00000512681.1_Intron|SPOCK3_ENST00000506886.1_Missense_Mutation_p.G76E|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000511531.1_Missense_Mutation_p.G76E|SPOCK3_ENST00000504953.1_Missense_Mutation_p.G73E|SPOCK3_ENST00000541637.1_Intron|SPOCK3_ENST00000541354.1_5'UTR|SPOCK3_ENST00000535728.1_5'UTR|SPOCK3_ENST00000502330.1_Missense_Mutation_p.G76E|SPOCK3_ENST00000511269.1_Missense_Mutation_p.G73E|SPOCK3_ENST00000534949.1_Intron|SPOCK3_ENST00000510741.1_Missense_Mutation_p.G73E|SPOCK3_ENST00000421836.2_Missense_Mutation_p.G25E	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	76					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		GAAGGGTTTTCCTGGACTCCA	0.308000													28	101					0	0	1	0	0
FBXW8	26259	broad.mit.edu	37	12	117383327	117383327	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:117383327C>T	ENST00000455858.2	+	3	457	c.384C>T	c.(382-384)aaC>aaT	p.N128N	FBXW8_ENST00000309909.5_Silent_p.N194N	NM_012174.1|NM_153348.2	NP_036306.1|NP_699179.2	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8	194	F-box.						protein binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	22	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		TACGAACCAACTGGAAGGTGG	0.488000													19	47					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70518713	70518713	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:70518713C>A	ENST00000310961.5	+	23	4293	c.3875C>A	c.(3874-3876)cCg>cAg	p.P1292Q	LRRC7_ENST00000035383.5_Missense_Mutation_p.P1334Q|LRRC7_ENST00000415775.2_Missense_Mutation_p.P618Q			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1334						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CAATAGACCCCGTCCCAGCAA	0.408000													33	116					1.96642e-18	2.00365e-18	1	1	0
VSIG2	23584	broad.mit.edu	37	11	124621325	124621325	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:124621325G>A	ENST00000403470.1	-	2	268	c.213C>T	c.(211-213)tcC>tcT	p.S71S	VSIG2_ENST00000326621.5_Silent_p.S71S			Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	71	Ig-like V-type.					integral to plasma membrane|membrane fraction				central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(5)	19	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		TCACTGGATGGGACTCAGAGA	0.622000													33	119					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430145	43430145	+	RNA	SNP	G	G	A	rs140504359		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:43430145G>A	ENST00000446844.3	-	0	1112				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				GGTAATAGGTGAATGAAGGGT	0.468000													69	250					0	0	1	0	0
CLIP3	25999	broad.mit.edu	37	19	36517066	36517066	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:36517066C>T	ENST00000360535.4	-	6	891	c.664G>A	c.(664-666)Gcc>Acc	p.A222T	AC002116.7_ENST00000586962.1_RNA|CLIP3_ENST00000593074.1_Missense_Mutation_p.A222T	NM_015526.2	NP_056341.1	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	222					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GCAGGGTTGGCGCCGTGCTCC	0.642000													20	48					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43484616	43484616	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:43484616G>A	ENST00000395891.1	+	11	2450	c.1845G>A	c.(1843-1845)gaG>gaA	p.E615E	HECW1_ENST00000453890.1_Silent_p.E615E	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	615					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CCCTGGAAGAGGACAGAGAAG	0.701000													5	35					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	157000156	157000156	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:157000156C>T	ENST00000348165.5	+	12	1843	c.1483C>T	c.(1483-1485)Cga>Tga	p.R495*		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	495					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		AGATTCTAGTCGAATCATCCC	0.373000													40	117					0	0	1	0	0
KLC1	3831	broad.mit.edu	37	14	104124053	104124053	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:104124053G>A	ENST00000389744.4	+	3	701	c.432G>A	c.(430-432)gaG>gaA	p.E144E	KLC1_ENST00000347839.6_Silent_p.E144E|KLC1_ENST00000557450.1_Silent_p.E144E|KLC1_ENST00000557575.1_Silent_p.E144E|KLC1_ENST00000445352.4_Silent_p.E144E|KLC1_ENST00000246489.7_Silent_p.E144E|KLC1_ENST00000554280.1_Silent_p.E144E|KLC1_ENST00000555836.1_Silent_p.E144E|KLC1_ENST00000334553.6_Silent_p.E144E|RP11-73M18.2_ENST00000472726.2_Silent_p.E316E|KLC1_ENST00000553286.1_Silent_p.E144E|KLC1_ENST00000452929.2_Silent_p.E144E|KLC1_ENST00000380038.3_Silent_p.E144E|KLC1_ENST00000348520.6_Silent_p.E144E			Q07866	KLC1_HUMAN	kinesin light chain 1	144					blood coagulation|microtubule-based movement|stress granule disassembly	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding		KLC1/ALK(2)	NS(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	12		Melanoma(154;0.155)|all_epithelial(191;0.19)				TGGAGGAGGAGAAGAAGCATC	0.473000													17	74					0	0	1	0	0
TSR3	115939	broad.mit.edu	37	16	1400959	1400959	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:1400959G>A	ENST00000007390.2	-	3	481	c.375C>T	c.(373-375)tcC>tcT	p.S125S		NM_001001410.2	NP_001001410.1			TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)																		GCCTGGCCCAGGAGCAGTCGA	0.642000													20	74					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613737	179613737	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179613737C>T	ENST00000360870.5	-	46	13612	c.13390G>A	c.(13390-13392)Gaa>Aaa	p.E4464K	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	592	Ig-like 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAATTTTTCAAATTCGATA	0.338000													26	61					0	0	1	0	0
FAM182B	728882	broad.mit.edu	37	20	25848614	25848614	+	Translation_Start_Site	SNP	C	C	A	rs144456407	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:25848614C>A	ENST00000376404.2	-	0	172				FAM182B_ENST00000478164.1_5'UTR																lung(1)	1						ccgggcaggcctgaggctggg	0.667000													4	18					0.0215528	0.0215892	1	1	0
UNC13C	440279	broad.mit.edu	37	15	54542433	54542433	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:54542433T>C	ENST00000545554.1	+	7	3239	c.3239T>C	c.(3238-3240)gTc>gCc	p.V1080A	UNC13C_ENST00000260323.11_Missense_Mutation_p.V1080A|UNC13C_ENST00000537900.1_Missense_Mutation_p.V1078A			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1080					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AAAATGCACGTCTTCAAGAAG	0.423000													8	52					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70279378	70279378	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:70279378C>T	ENST00000346329.3	+	15	1635	c.1327C>T	c.(1327-1329)Ccc>Tcc	p.P443S	CTTN_ENST00000538675.1_Missense_Mutation_p.P164S|CTTN_ENST00000376561.3_Missense_Mutation_p.P443S|CTTN_ENST00000301843.8_Missense_Mutation_p.P480S	NM_138565.2	NP_612632.1	Q14247	SRC8_HUMAN	cortactin	480						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GGGCCACTATCCCGCAGGTAC	0.687000													12	29					0	0	1	0	0
PPWD1	23398	broad.mit.edu	37	5	64867905	64867905	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:64867905C>T	ENST00000261308.5	+	5	833	c.761C>T	c.(760-762)cCt>cTt	p.P254L	PPWD1_ENST00000535264.1_Missense_Mutation_p.P224L|PPWD1_ENST00000538977.1_Missense_Mutation_p.P98L	NM_015342.3	NP_056157.1	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat containing 1	254					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	19		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)		ACTGGGCCTCCTCATGAATAT	0.398000													33	113					0	0	1	0	0
RBM33	155435	broad.mit.edu	37	7	155493559	155493559	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:155493559C>T	ENST00000401878.3	+	6	858	c.660C>T	c.(658-660)ttC>ttT	p.F220F	RBM33_ENST00000287912.3_Silent_p.F220F|RBM33_ENST00000392759.3_Silent_p.F260F	NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	220	Glu-rich.						nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		GATTACGTTTCAAAACTGAAA	0.373000													14	9					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				52	68					0	0	1	0	0
DPPA3	359787	broad.mit.edu	37	12	7864234	7864234	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:7864234C>T	ENST00000345088.2	+	1	185	c.68C>T	c.(67-69)tCc>tTc	p.S23F		NM_199286.2	NP_954980.1	Q6W0C5	DPPA3_HUMAN	developmental pluripotency associated 3	23						cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)	8				Kidney(36;0.0887)		GAAGAAAATTCCCGGGACGAT	0.468000													16	41					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112693	57112693	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:57112693G>A	ENST00000454682.1	-	3	2902	c.2621C>T	c.(2620-2622)tCt>tTt	p.S874F	NACA_ENST00000548563.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000550952.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TCCTTTGGGAGACAGAGGAGT	0.567000			T	BCL6	NHL								9	35					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138698587	138698587	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:138698587C>T	ENST00000520602.1	-	12	1510	c.1225G>A	c.(1225-1227)Gaa>Aaa	p.E409K	MCF2_ENST00000370576.4_Missense_Mutation_p.E349K|MCF2_ENST00000414978.1_Missense_Mutation_p.E409K|MCF2_ENST00000370573.4_Missense_Mutation_p.E349K|MCF2_ENST00000536274.1_Missense_Mutation_p.E310K|MCF2_ENST00000370578.4_Missense_Mutation_p.E494K|MCF2_ENST00000519895.1_Missense_Mutation_p.E409K|MCF2_ENST00000338585.6_Missense_Mutation_p.E349K			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	349					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					TTATCTATTTCCTGATTAGCT	0.323000													36	41					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44218052	44218052	+	Missense_Mutation	SNP	A	A	G	rs146748945		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:44218052A>G	ENST00000371554.1	+	6	887	c.673A>G	c.(673-675)Att>Gtt	p.I225V	HSP90AB1_ENST00000371646.5_Missense_Mutation_p.I225V|HSP90AB1_ENST00000353801.3_Missense_Mutation_p.I225V			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	225					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			agagaaggaaattagtgatga	0.413000													36	128					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118698861	118698861	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:118698861G>A	ENST00000376300.2	-	19	1563	c.1426C>T	c.(1426-1428)Cga>Tga	p.R476*	CCDC93_ENST00000319432.5_Nonsense_Mutation_p.R475*	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	476										breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						GCTATTTCTCGATTTCTTCGA	0.443000													30	79					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	83					0	0	1	0	0
DUOX2	50506	broad.mit.edu	37	15	45394109	45394109	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:45394109C>T	ENST00000389039.6	-	21	3118	c.2733G>A	c.(2731-2733)tcG>tcA	p.S911S	DUOX2_ENST00000603300.1_Silent_p.S911S			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	911	EF-hand 3.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CCTGGAATCCCGACTCCCGGA	0.572000													30	72					0	0	1	0	0
BATF3	55509	broad.mit.edu	37	1	212860168	212860168	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:212860168G>A	ENST00000243440.1	-	3	571	c.349C>T	c.(349-351)Cgg>Tgg	p.R117W	BATF3_ENST00000478275.1_5'UTR	NM_018664.2	NP_061134.1	Q9NR55	BATF3_HUMAN	basic leucine zipper transcription factor, ATF-like 3	117					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0046)|all cancers(67;0.00785)|GBM - Glioblastoma multiforme(131;0.0731)|Epithelial(68;0.0781)		GGGTCCGGCCGGGGAGGCACT	0.612000													28	108					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767021	77767021	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:77767021G>A	ENST00000521891.2	+	10	8312	c.7864G>A	c.(7864-7866)Gaa>Aaa	p.E2622K	ZFHX4_ENST00000518282.1_Missense_Mutation_p.E2596K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E2577K|ZFHX4_ENST00000050961.6_Missense_Mutation_p.E2577K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2577						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATACTCTATGAAAAATACTT	0.453000										HNSCC(33;0.089)			7	33					0	0	1	0	0
DNAAF1	123872	broad.mit.edu	37	16	84182624	84182624	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:84182624C>T	ENST00000378553.5	+	2	261	c.137C>T	c.(136-138)cCt>cTt	p.P46L	DNAAF1_ENST00000334315.5_Missense_Mutation_p.P46L	NM_178452.4	NP_848547.4	Q8NEP3	DAAF1_HUMAN	dynein, axonemal, assembly factor 1	46			Missing (in CILD13).		axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding			NS(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(4)|urinary_tract(1)	41						ATTAATGATCCTAAGGAAATA	0.418000													22	73					0	0	1	0	0
FZD8	8325	broad.mit.edu	37	10	35928312	35928312	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:35928312G>A	ENST00000374694.1	-	1	2050	c.2046C>T	c.(2044-2046)tcC>tcT	p.S682S		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	682					axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						GATAAGACACGGAGCTCGCCG	0.746000													3	11					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91835652	91835652	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:91835652G>A	ENST00000394232.1	+	13	2392	c.1922G>A	c.(1921-1923)gGa>gAa	p.G641E	SV2B_ENST00000330276.4_Missense_Mutation_p.G641E|SV2B_ENST00000545111.2_Missense_Mutation_p.G490E	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	641					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GCCATCCTGGGAAACACCATC	0.473000													36	123					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199454	4199454	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:4199454G>A	ENST00000296358.4	-	5	1131	c.1107C>T	c.(1105-1107)atC>atT	p.I369I		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	369					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TGTAAATCCGGATTCCAGCCA	0.582000													39	105					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73721309	73721309	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:73721309C>T	ENST00000427855.1	+	13	1493	c.1391C>T	c.(1390-1392)tCc>tTc	p.S464F	PAPLN_ENST00000340738.5_Missense_Mutation_p.S437F|PAPLN_ENST00000555445.1_Missense_Mutation_p.S464F|PAPLN_ENST00000381166.3_Missense_Mutation_p.S464F|PAPLN_ENST00000554301.1_Missense_Mutation_p.S464F			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	464	TSP type-1 4.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCAGCGTGCTCCTTGGAAGAC	0.602000													51	160					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92258028	92258028	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:92258028A>C	ENST00000298047.6	+	2	3538	c.3521A>C	c.(3520-3522)gAt>gCt	p.D1174A	FAT3_ENST00000525166.1_Missense_Mutation_p.D1024A|FAT3_ENST00000409404.2_Missense_Mutation_p.D1174A|FAT3_ENST00000541502.1_Missense_Mutation_p.D1174A			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1174	Cadherin 11.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGGCTGAAGATCCTGACTCC	0.408000										TCGA Ovarian(4;0.039)			8	33					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95497824	95497824	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:95497824C>T	ENST00000432432.2	-	0	1019					NR_040113.1																						GACACTTTCTCGGGGACACAC	0.353000													77	198					0	0	1	0	0
IMMP2L	83943	broad.mit.edu	37	7	110303777	110303777	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:110303777C>T	ENST00000405709.2	-	6	851	c.408_splice	c.e6-1	p.V137_splice	IMMP2L_ENST00000450877.1_Splice_Site_p.V119_splice|IMMP2L_ENST00000452895.1_Splice_Site_p.V137_splice|IMMP2L_ENST00000489381.1_5'UTR|IMMP2L_ENST00000415362.1_Splice_Site_p.V137_splice|IMMP2L_ENST00000331762.3_Splice_Site_p.V137_splice	NM_032549.3	NP_115938.1	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	137					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity			endometrium(3)|large_intestine(6)|lung(5)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		CCTAGGGAAACCTTAATTCAT	0.413000													12	70					0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	G	A	rs143435240	byFrequency	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:51076024G>A	ENST00000376006.3	+	2	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_ENST00000356450.2_Silent_p.E69E	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(8)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000													3	41					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134118747	134118747	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:134118747C>T	ENST00000452510.2	+	9	1316	c.1158C>T	c.(1156-1158)tcC>tcT	p.S386S	DDX46_ENST00000354283.4_Silent_p.S386S|DDX46_ENST00000509178.1_3'UTR	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	386					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCTTAAATTCCCTCAAGAAGT	0.413000													28	90					0	0	1	0	0
PFKFB4	5210	broad.mit.edu	37	3	48587554	48587554	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:48587554G>A	ENST00000232375.3	-	2	323	c.211C>T	c.(211-213)Cgg>Tgg	p.R71W	PFKFB4_ENST00000545984.1_Missense_Mutation_p.R71W|PFKFB4_ENST00000541519.1_Missense_Mutation_p.R37W|PFKFB4_ENST00000536104.1_Missense_Mutation_p.R60W|PFKFB4_ENST00000383734.2_Missense_Mutation_p.R71W|PFKFB4_ENST00000490115.1_5'UTR|PFKFB4_ENST00000416568.1_Missense_Mutation_p.R71W	NM_004567.2	NP_004558.1	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	71	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		GCCTCACCCCGAGTGGGCACA	0.562000													20	64					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178556940	178556940	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:178556940G>A	ENST00000251582.7	-	16	2551	c.2450C>T	c.(2449-2451)aCc>aTc	p.T817I		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	817	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CACCAGAACGGTGATGGTGCC	0.662000													19	62					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765901	77765901	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:77765901C>T	ENST00000521891.2	+	10	7192	c.6744C>T	c.(6742-6744)aaC>aaT	p.N2248N	ZFHX4_ENST00000518282.1_Silent_p.N2222N|ZFHX4_ENST00000455469.2_Silent_p.N2203N|ZFHX4_ENST00000050961.6_Silent_p.N2203N	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2203						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTGACACAAACGCTTACCCAA	0.403000										HNSCC(33;0.089)			10	42					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024483	55024483	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:55024483C>T	ENST00000324000.3	+	3	2676	c.642C>T	c.(640-642)atC>atT	p.I214I		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	214					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	p.I214I(1)		breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		ACCCCAGCATCCTGGAAAAAT	0.408000													35	89					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141248397	141248397	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:141248397G>A	ENST00000287008.3	-	2	787	c.640C>T	c.(640-642)Cag>Tag	p.Q214*	PCDH1_ENST00000503492.1_Nonsense_Mutation_p.Q214*|PCDH1_ENST00000536585.1_Nonsense_Mutation_p.Q192*|PCDH1_ENST00000394536.3_Nonsense_Mutation_p.Q214*|PCDH1_ENST00000456271.1_Intron	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	214	Cadherin 2.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		AATAGCTCCTGGGCCTCAGGC	0.607000													44	115					0	0	1	0	0
GHDC	84514	broad.mit.edu	37	17	40343091	40343091	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:40343091C>T	ENST00000301671.8	-	5	1468	c.1027G>A	c.(1027-1029)Gcc>Acc	p.A343T	GHDC_ENST00000428494.2_Missense_Mutation_p.A304T|GHDC_ENST00000593209.1_Missense_Mutation_p.A343T|GHDC_ENST00000414034.3_Missense_Mutation_p.A343T|GHDC_ENST00000436923.2_Missense_Mutation_p.A343T|GHDC_ENST00000587427.1_Missense_Mutation_p.A343T			Q8N2G8	GHDC_HUMAN	GH3 domain containing	343						endoplasmic reticulum|nuclear envelope				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CCCTGCTGGGCCTCGGCCAAA	0.657000													30	85					0	0	1	0	0
LTB4R2	56413	broad.mit.edu	37	14	24780831	24780831	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:24780831A>G	ENST00000528054.1	+	1	2671	c.1054A>G	c.(1054-1056)Agg>Ggg	p.R352G	LTB4R2_ENST00000533293.1_Missense_Mutation_p.R321G|LTB4R2_ENST00000543919.1_Missense_Mutation_p.R321G|LTB4R_ENST00000345363.3_5'UTR			Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	352					chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane				endometrium(1)|lung(1)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.018)		CGGCCGCTCTAGGGAAGGGAC	0.682000													37	87					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43246329	43246329	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:43246329G>A	ENST00000422911.1	-	14	1888	c.1787C>T	c.(1786-1788)cCg>cTg	p.P596L	PRDM15_ENST00000269844.3_Missense_Mutation_p.P905L|PRDM15_ENST00000538201.1_Missense_Mutation_p.P559L|PRDM15_ENST00000447207.2_Missense_Mutation_p.P539L|PRDM15_ENST00000398548.1_Missense_Mutation_p.P576L			P57071	PRD15_HUMAN	PR domain containing 15	905					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						GCCACACACCGGGCACCCGGA	0.542000													59	145					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17401363	17401363	+	Missense_Mutation	SNP	T	T	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:17401363T>C	ENST00000375486.4	-	13	1600	c.1537A>G	c.(1537-1539)Atc>Gtc	p.I513V	PADI2_ENST00000466151.1_5'UTR|PADI2_ENST00000444885.2_Missense_Mutation_p.I397V	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	513					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TTGAACATGATGGCCTCTCCA	0.582000													14	38					0	0	1	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686185	108686185	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:108686185C>T	ENST00000312143.7	-	3	918	c.555G>A	c.(553-555)ggG>ggA	p.G185G	CMKLR1_ENST00000550402.1_Silent_p.G185G|CMKLR1_ENST00000552995.1_Silent_p.G183G|CMKLR1_ENST00000412676.1_Silent_p.G185G|CMKLR1_ENST00000397688.2_Silent_p.G183G	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	185					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						AGGATATTTTCCCATGCAGGT	0.567000													37	69					0	0	1	0	0
SATL1	340562	broad.mit.edu	37	X	84362659	84362659	+	Missense_Mutation	SNP	C	C	T	rs140076762	byFrequency	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:84362659C>T	ENST00000509231.1	-	1	1395	c.1316G>A	c.(1315-1317)cGa>cAa	p.R439Q	SATL1_ENST00000395409.3_Missense_Mutation_p.R252Q|SATL1_ENST00000332921.5_Missense_Mutation_p.R252Q			Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	252	Acetyl-CoA binding (By similarity).|N-acetyltransferase.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						CCACATGCCTCGTTGCCACAT	0.552000													86	72					0	0	1	0	0
KRT6A	3853	broad.mit.edu	37	12	52882288	52882288	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:52882288C>T	ENST00000330722.6	-	7	1316	c.1248G>A	c.(1246-1248)ggG>ggA	p.G416G		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	416	Coil 2.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		GGGCCATCTCCCCACGCTGCT	0.582000													42	142					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903404	4903404	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:4903404G>T	ENST00000380378.1	+	1	356	c.356G>T	c.(355-357)cGg>cTg	p.R119L	MMP26_ENST00000380390.1_Intron|OR51T1_ENST00000322049.1_Missense_Mutation_p.R92L|MMP26_ENST00000477339.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTTCATGCCCGGGAGATCAGC	0.488000													34	98					6.05902e-23	6.21653e-23	1	1	0
TMEM171	134285	broad.mit.edu	37	5	72424277	72424277	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:72424277C>T	ENST00000454765.2	+	3	1174	c.701C>T	c.(700-702)tCt>tTt	p.S234F	TMEM171_ENST00000287773.5_Missense_Mutation_p.S234F			Q8WVE6	TM171_HUMAN	transmembrane protein 171	234						integral to membrane				endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)	15		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		TCTTCAGCTTCTGCGGTCGCT	0.413000													93	275					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88423594	88423594	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:88423594G>A	ENST00000394480.1	-	18	2520	c.2199C>T	c.(2197-2199)ttC>ttT	p.F733F	NTRK3_ENST00000357724.2_Silent_p.F739F|NTRK3_ENST00000557856.1_Silent_p.F725F|NTRK3_ENST00000355254.2_Silent_p.F733F|NTRK3_ENST00000360948.2_Silent_p.F747F	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	747	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTCTGTAGTGAACTTCCGGT	0.507000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			20	68					0	0	1	0	0
FAM53B	9679	broad.mit.edu	37	10	126370393	126370393	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:126370393G>A	ENST00000337318.3	-	4	900	c.689C>T	c.(688-690)tCt>tTt	p.S230F	FAM53B_ENST00000280780.6_Missense_Mutation_p.S230F|RP11-12J10.3_ENST00000494792.1_3'UTR|FAM53B_ENST00000392754.3_Missense_Mutation_p.S230F	NM_014661.3	NP_055476.3	Q14153	FA53B_HUMAN	family with sequence similarity 53, member B	230										cervix(1)|lung(5)|ovary(2)|pancreas(1)	9		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		ATGTGAGCAAGAGAGGGACCG	0.642000													6	10					0	0	1	0	0
DCN	1634	broad.mit.edu	37	12	91552220	91552220	+	Silent	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:91552220A>G	ENST00000052754.5	-	4	892	c.391T>C	c.(391-393)Ttg>Ctg	p.L131L	DCN_ENST00000456569.2_Intron|DCN_ENST00000547568.2_Intron|DCN_ENST00000228329.5_Intron|DCN_ENST00000441303.2_Intron|DCN_ENST00000420120.2_Intron|DCN_ENST00000425043.1_Intron|DCN_ENST00000552962.1_Silent_p.L131L|DCN_ENST00000303320.3_Intron|DCN_ENST00000393155.1_Silent_p.L131L	NM_001920.3	NP_001911.1	P07585	PGS2_HUMAN	decorin	131					organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						AGTCGTTCCAACTTCACCAAA	0.393000													56	149					0	0	1	0	0
TAS2R50	259296	broad.mit.edu	37	12	11138717	11138717	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:11138717G>A	ENST00000506868.1	-	1	794	c.743C>T	c.(742-744)tCg>tTg	p.S248L	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176890.2	NP_795371.2	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	248					sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.S248L(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)	17						ACTCCAAACCGAAACGATTAG	0.443000													43	106					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159921544	159921544	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:159921544G>A	ENST00000368093.3	-	4	893	c.777C>T	c.(775-777)gtC>gtT	p.V259V	SLAMF9_ENST00000368092.3_Silent_p.V168V|SLAMF9_ENST00000466773.1_5'UTR	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	259						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTCTTTTCTGGACTCGGATGA	0.507000													49	232					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23189565	23189565	+	Missense_Mutation	SNP	G	G	A	rs142113032		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:23189565G>A	ENST00000400191.3	+	4	865	c.847G>A	c.(847-849)Gat>Aat	p.D283N	EPHB2_ENST00000374632.3_Missense_Mutation_p.D283N|EPHB2_ENST00000374630.3_Missense_Mutation_p.D283N|EPHB2_ENST00000544305.1_Missense_Mutation_p.D283N|EPHB2_ENST00000465676.1_3'UTR|EPHB2_ENST00000374627.1_Missense_Mutation_p.D277N	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	283	Cys-rich.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CAACCAAGGGGATGAGGCCTG	0.562000													47	165					0	0	1	0	0
IDUA	3425	broad.mit.edu	37	4	997863	997863	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:997863G>C	ENST00000453894.1	+	10	1945	c.1857G>C	c.(1855-1857)agG>agC	p.R619S	IDUA_ENST00000514224.1_Missense_Mutation_p.R465S|IDUA_ENST00000247933.4_Missense_Mutation_p.R597S			P35475	IDUA_HUMAN	iduronidase, alpha-L-	597			R -> G (in MPS1H/S; 1.5% of normal activity).		disaccharide metabolic process	lysosome	cation binding|L-iduronidase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(23;0.0158)		Laronidase(DB00090)	CGGTCAGCAGGAAGCCATCGA	0.617000													75	188					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28272896	28272896	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:28272896G>A	ENST00000305242.5	-	6	787	c.695C>T	c.(694-696)tCa>tTa	p.S232L	ARMC4_ENST00000239715.3_Missense_Mutation_p.S89L	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	232							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						ACATCCATTTGAAAATTCATA	0.403000													28	65					0	0	1	0	0
TRAJ28	28727	broad.mit.edu	37	14	22984637	22984637	+	RNA	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:22984637G>A	ENST00000390509.1	+	0	37																											CTCACTTTCGGGAAGGGGACC	0.463000													10	16					0	0	1	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													4	95					0	0	1	0	0
BAAT	570	broad.mit.edu	37	9	104133271	104133271	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:104133271C>T	ENST00000259407.2	-	2	524	c.416G>A	c.(415-417)cGa>cAa	p.R139Q	BAAT_ENST00000395051.3_Missense_Mutation_p.R139Q	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	139					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	AACCTTAATTCGTGTGACACC	0.433000													38	111					0	0	1	0	0
CREB3L1	90993	broad.mit.edu	37	11	46332687	46332687	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:46332687A>G	ENST00000529193.1	+	5	1151	c.700A>G	c.(700-702)Atg>Gtg	p.M234V	CREB3L1_ENST00000288400.3_Missense_Mutation_p.M234V			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	234					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		TGTCAGGCCCATGGCGCGCTC	0.662000			T	FUS	myxofibrosarcoma								18	50					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40360450	40360450	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:40360450C>T	ENST00000338305.6	-	3	2144	c.1602G>A	c.(1600-1602)atG>atA	p.M534I		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	534						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGACCAGGATCATGGTGCCGC	0.612000													30	70					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36779920	36779920	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:36779920C>T	ENST00000416516.2	-	2	721	c.231G>A	c.(229-231)ggG>ggA	p.G77G		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	77						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						CGGGGATCTTCCCCTGGTGCC	0.607000													71	186					0	0	1	0	0
IGHV3-20	28445	broad.mit.edu	37	14	106667641	106667641	+	RNA	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:106667641G>A	ENST00000390606.2	-	0	352																											GCAGATACAGGGAGTTCTTGG	0.522000													117	306					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37186482	37186482	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:37186482G>A	ENST00000274258.7	-	24	4325	c.738C>T	c.(736-738)ttC>ttT	p.F246F	C5orf42_ENST00000508244.1_Silent_p.F1365F|C5orf42_ENST00000425232.2_Silent_p.F1365F			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1365										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ATGCTTTCACGAAAATTTCTG	0.328000													23	90					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78907151	78907151	+	Missense_Mutation	SNP	G	G	A	rs118069479	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:78907151G>A	ENST00000545128.1	+	25	3683	c.3145G>A	c.(3145-3147)Gat>Aat	p.D1049N		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	749					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TTTTCCAGATGATCCAGGAAC	0.363000													48	108					0	0	1	0	0
CHCHD7	79145	broad.mit.edu	37	8	57128950	57128950	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:57128950C>T	ENST00000518801.1	+	4	241	c.93C>T	c.(91-93)atC>atT	p.I31I	CHCHD7_ENST00000303759.3_Intron|CHCHD7_ENST00000519367.1_Silent_p.I19I|CHCHD7_ENST00000517933.1_Intron|CHCHD7_ENST00000521524.1_Silent_p.I31I|CHCHD7_ENST00000523061.1_Intron|CHCHD7_ENST00000521831.1_Silent_p.I19I|CHCHD7_ENST00000396723.5_Intron|CHCHD7_ENST00000523975.1_Intron|CHCHD7_ENST00000355315.3_Intron			Q9BUK0	CHCH7_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 7	0	CHCH.								CHCHD7/PLAG1(12)	endometrium(1)	1		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00159)|all cancers(17;0.0112)			gcttTTAGATCCTGTTCTACC	0.353000			T	PLAG1	salivary adenoma								9	34					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99942489	99942489	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:99942489C>T	ENST00000524871.1	+	12	1642	c.1352C>T	c.(1351-1353)tCa>tTa	p.S451L	CNTN5_ENST00000418526.2_Missense_Mutation_p.S377L|CNTN5_ENST00000527185.1_Missense_Mutation_p.S451L|CNTN5_ENST00000279463.3_Missense_Mutation_p.S451L|CNTN5_ENST00000528682.1_Missense_Mutation_p.S451L	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	451	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GTGAATCAATCAGATGCTGGA	0.343000													5	18					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66466210	66466210	+	RNA	SNP	C	C	T	rs147345298	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:66466210C>T	ENST00000424345.1	+	0	843																											acctgagtgactctctcctag	0.438000													3	21					0	0	1	0	0
FAM181A	90050	broad.mit.edu	37	14	94395412	94395412	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:94395412G>A	ENST00000267594.5	+	3	1274	c.967G>A	c.(967-969)Ggc>Agc	p.G323S	FAM181A_ENST00000557719.1_Missense_Mutation_p.G261S|FAM181A_ENST00000557000.2_Missense_Mutation_p.G261S|FAM181A_ENST00000556222.1_Missense_Mutation_p.G261S	NM_001207073.1|NM_001207074.1|NM_138344.4	NP_001194002.1|NP_001194003.1|NP_612353.3	Q8N9Y4	F181A_HUMAN	family with sequence similarity 181, member A	323										cervix(1)|endometrium(2)|large_intestine(8)|lung(4)|prostate(1)|skin(2)	18						GGATGTGGACGGCCTGGGGCA	0.652000													25	73					0	0	1	0	0
LRRC8D	55144	broad.mit.edu	37	1	90399484	90399484	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:90399484C>T	ENST00000337338.5	+	3	1264	c.857C>T	c.(856-858)gCc>gTc	p.A286V	LRRC8D_ENST00000394593.3_Missense_Mutation_p.A286V	NM_001134479.1	NP_001127951.1	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member D	286						integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(2)|skin(1)	29		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		CAGGCCAAAGCCCTGTTTGAG	0.418000													18	42					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72992838	72992838	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:72992838G>A	ENST00000268489.5	-	2	1879	c.1207C>T	c.(1207-1209)Ctt>Ttt	p.L403F	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	403					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGCCCGCCAAGGTTCAACAGG	0.642000													53	157					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793074	65793074	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:65793074C>T	ENST00000312106.5	-	1	914	c.777G>A	c.(775-777)ggG>ggA	p.G259G		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	259	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						agtCAGATATCCCACGCTGGT	0.562000													6	13					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134942326	134942326	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:134942326G>A	ENST00000607359.1	+	16	3151	c.3151G>A	c.(3151-3153)Gac>Aac	p.D1051N	GPR123_ENST00000392607.3_Missense_Mutation_p.D332N|GPR123_ENST00000392606.2_Missense_Mutation_p.D235N			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	332						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CCCCGCACTTGACGCCAACGG	0.731000													6	19					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7081197	7081197	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:7081197G>A	ENST00000299481.4	+	9	3052	c.2706G>A	c.(2704-2706)ctG>ctA	p.L902L		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	902					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ACAAGAGCCTGACGCATCTGG	0.448000													43	146					0	0	1	0	0
SERPINB6	5269	broad.mit.edu	37	6	2948850	2948850	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:2948850G>A	ENST00000380520.1	-	6	2807	c.813C>T	c.(811-813)ctC>ctT	p.L271L	SERPINB6_ENST00000335686.5_Silent_p.L271L|SERPINB6_ENST00000380529.1_Silent_p.L271L|SERPINB6_ENST00000380539.1_Silent_p.L271L|SERPINB6_ENST00000380524.1_Silent_p.L271L|SERPINB6_ENST00000380546.3_Silent_p.L271L			P35237	SPB6_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 6	271					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|stomach(1)|upper_aerodigestive_tract(2)	17	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	TAAACCGCGGGAGGGACACTT	0.527000													93	302					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43266441	43266441	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:43266441G>A	ENST00000372585.5	+	1	440	c.345G>A	c.(343-345)caG>caA	p.Q115Q	SLC22A7_ENST00000372574.3_Silent_p.Q115Q|SLC22A7_ENST00000487175.1_3'UTR|SLC22A7_ENST00000372589.3_Silent_p.Q115Q	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	115						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CCTGCTCTCAGGGCTGGGAGT	0.572000													21	65					0	0	1	0	0
FPR3	2359	broad.mit.edu	37	19	52327708	52327708	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:52327708C>T	ENST00000339223.4	+	2	886	c.707C>T	c.(706-708)tCc>tTc	p.S236F	FPR3_ENST00000595991.1_Missense_Mutation_p.S236F	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	236					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						ATGATTAAATCCAGCCGTCCC	0.458000													19	44					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156592658	156592658	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:156592658G>A	ENST00000302938.4	-	1	617	c.522C>T	c.(520-522)ctC>ctT	p.L174L		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	174						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGCCTCAGGAGATAGACAA	0.498000													70	241					0	0	1	0	0
TRAV8-4	28682	broad.mit.edu	37	14	22363110	22363110	+	RNA	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:22363110G>A	ENST00000390438.2	+	0	369																											AGGCATCAACGGTTTTGAGGC	0.502000													78	175					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14861545	14861545	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:14861545G>A	ENST00000285046.5	+	1	1077	c.967G>A	c.(967-969)Gag>Aag	p.E323K	FGD5_ENST00000543601.1_Missense_Mutation_p.E82K	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	323	Glu-rich.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GTCCGCCGAGGAGAGCTGCCA	0.552000													38	91					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38862525	38862525	+	Nonsense_Mutation	SNP	C	C	T	rs149070832	byFrequency	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:38862525C>T	ENST00000359357.3	+	57	8235	c.7981C>T	c.(7981-7983)Cga>Tga	p.R2661*	DNAH8_ENST00000441566.1_Nonsense_Mutation_p.R2625*|DNAH8_ENST00000449981.2_Nonsense_Mutation_p.R2878*					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTTCAATCTTCGAGATCTTTC	0.393000													18	51					0	0	1	0	0
NPM1	4869	broad.mit.edu	37	5	170814963	170814963	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:170814963C>T	ENST00000296930.5	+	1	312	c.11C>T	c.(10-12)tCg>tTg	p.S4L	NPM1_ENST00000517671.1_Missense_Mutation_p.S4L|NPM1_ENST00000393820.2_Missense_Mutation_p.S4L|NPM1_ENST00000351986.6_Missense_Mutation_p.S4L	NM_002520.6	NP_002511.1	P06748	NPM_HUMAN	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	4	Met-rich.|Necessary for interaction with APEX1.|Required for interaction with SENP3.				anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4261)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	4269	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ATGGAAGATTCGATGGACATG	0.607000			"""T, F """	"""ALK, RARA, MLF1"""	"""NHL, APL, AML"""								17	60					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45312224	45312224	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr22:45312224G>A	ENST00000313237.5	-	4	650	c.500C>T	c.(499-501)aCc>aTc	p.T167I	PHF21B_ENST00000403565.1_Missense_Mutation_p.T5I|PHF21B_ENST00000396103.3_Missense_Mutation_p.T167I|PHF21B_ENST00000404079.2_Missense_Mutation_p.T155I|PHF21B_ENST00000447824.3_Missense_Mutation_p.T155I	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	167							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		AGACACGGCGGTGCTGGGGGC	0.672000													13	27					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123982691	123982691	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:123982691C>T	ENST00000306315.5	-	4	3821	c.3386G>A	c.(3385-3387)aGg>aAg	p.R1129K	ZNF608_ENST00000504926.1_Missense_Mutation_p.R702K	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1129						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CTCACTTTTCCTTTCACAGTC	0.517000													38	106					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79270107	79270107	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:79270107C>T	ENST00000554719.1	+	6	1561	c.1070C>T	c.(1069-1071)tCt>tTt	p.S357F	NRXN3_ENST00000335750.5_Missense_Mutation_p.S357F	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	134					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TCCAGGGACTCTGCCGACACC	0.562000													22	76					0	0	1	0	0
SRP68	6730	broad.mit.edu	37	17	74060072	74060072	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:74060072G>A	ENST00000307877.2	-	4	707	c.546C>T	c.(544-546)acC>acT	p.T182T	SRP68_ENST00000355113.5_Silent_p.T81T|SRP68_ENST00000539137.1_Silent_p.T144T	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	182					response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						CCTCTAATTTGGTCTTGGCAT	0.433000													33	89					0	0	1	0	0
ELMSAN1	91748	broad.mit.edu	37	14	74188090	74188090	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:74188090G>A	ENST00000286523.5	-	11	3629	c.2847C>T	c.(2845-2847)atC>atT	p.I949I	ELMSAN1_ENST00000394071.2_Silent_p.I949I	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		ccttctcttggatctctggca	0.617000													18	41					0	0	1	0	0
CCL14	6358	broad.mit.edu	37	17	34313585	34313585	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:34313585G>A	ENST00000591669.1	+	2	157	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K	CCL14_ENST00000394509.4_Intron|CTB-186H2.3_ENST00000593057.1_Intron|CCL14_ENST00000586216.1_Intron|CCL14_ENST00000536149.1_Intron|CCL15-CCL14_ENST00000481427.2_Intron|CCL14_ENST00000435911.2_Intron|CCL14_ENST00000480944.2_5'UTR																							AGGTTGGAAGGAAGACAAGGC	0.547000													12	31					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40662091	40662091	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:40662091C>T	ENST00000267889.3	+	8	3865	c.3778C>T	c.(3778-3780)Ctg>Ttg	p.L1260L		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	1260					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GGCTGAGCCCCTGCCAGCCTC	0.667000													16	42					0	0	1	0	0
ST3GAL5	8869	broad.mit.edu	37	2	86090557	86090557	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:86090557G>A	ENST00000377332.3	-	2	242	c.134C>T	c.(133-135)cCt>cTt	p.P45L	ST3GAL5_ENST00000393805.1_Missense_Mutation_p.P17L|ST3GAL5_ENST00000393808.3_Missense_Mutation_p.P22L|ST3GAL5_ENST00000525834.2_Missense_Mutation_p.P45L|ST3GAL5_ENST00000484728.1_5'UTR	NM_003896.3	NP_003887.3	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	45					ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15						TTGCAGGGAAGGCCTCGAGCA	0.498000													26	82					0	0	1	0	0
CRHR2	1395	broad.mit.edu	37	7	30721619	30721619	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:30721619G>A	ENST00000471646.1	-	2	558	c.141C>T	c.(139-141)atC>atT	p.I47I	CRHR2_ENST00000348438.4_Silent_p.I74I|CRHR2_ENST00000341843.4_Silent_p.I33I|CRHR2_ENST00000506074.2_Silent_p.I47I	NM_001202482.1|NM_001202483.1|NM_001883.4	NP_001189411.1|NP_001189412.1|NP_001874.2	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	47					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						AGCACGTTCCGATCTGGTCCA	0.687000													4	15					0	0	1	0	0
TMEM217	221468	broad.mit.edu	37	6	37186390	37186390	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:37186390G>A	ENST00000336655.2	-	2	456	c.417C>T	c.(415-417)caC>caT	p.H139H	TMEM217_ENST00000497775.1_Intron|TMEM217_ENST00000356757.2_Silent_p.H139H	NM_145316.3	NP_660359.2	Q8N7C4	TM217_HUMAN	transmembrane protein 217	139						integral to membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(1)	9						TCCAGAAACAGTGCATGACTG	0.433000													62	195					0	0	1	0	0
MCPH1	79648	broad.mit.edu	37	8	6357405	6357405	+	Silent	SNP	T	T	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:6357405T>C	ENST00000344683.5	+	12	2245	c.2169T>C	c.(2167-2169)atT>atC	p.I723I	ANGPT2_ENST00000325203.5_3'UTR|ANGPT2_ENST00000415216.1_3'UTR	NM_024596.3	NP_078872.2	Q8NEM0	MCPH1_HUMAN	microcephalin 1	723	BRCT 2.					microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		GTCACTGGATTTCTGAGGAGC	0.418000													36	103					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52271915	52271915	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:52271915G>A	ENST00000598776.1	+	2	776	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	FPR2_ENST00000598953.1_Missense_Mutation_p.E2K|FPR2_ENST00000340023.6_Missense_Mutation_p.E2K	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	2					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						TGGCAAGATGGAAACCAACTT	0.468000													19	47					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67992406	67992406	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:67992406C>T	ENST00000397942.3	+	2	818	c.502C>T	c.(502-504)Ctg>Ttg	p.L168L	SOCS6_ENST00000582322.1_Silent_p.L168L	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	168					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GAGTCCAGCCCTGAATGGCGT	0.587000													34	76					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76502850	76502850	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:76502850G>A	ENST00000389840.5	-	30	4867	c.4743C>T	c.(4741-4743)tcC>tcT	p.S1581S	DNAH17_ENST00000585328.1_Silent_p.S1582S					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGTCAGCCGAGGAGACAAAAT	0.537000													27	76					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28600569	28600569	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:28600569C>T	ENST00000253063.3	+	7	1241	c.920C>T	c.(919-921)tCt>tTt	p.S307F		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	307					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		CTGGAGCCCTCTCCACACCCA	0.577000													44	106					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89692775	89692775	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:89692775C>T	ENST00000371953.3	+	5	1616	c.259C>T	c.(259-261)Caa>Taa	p.Q87*		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	87	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.Y27fs*1(2)|p.Q87_P96del(1)|p.N82_P95del(1)|p.F56fs*2(1)|p.Q87*(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CACAGTTGCACAATATCCTTT	0.328000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			28	59					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28669511	28669511	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:28669511C>T	ENST00000280904.6	-	5	964	c.521G>A	c.(520-522)aGa>aAa	p.R174K	DSC2_ENST00000251081.6_Missense_Mutation_p.R174K	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	174	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCCAGGACCTCTTATGGAATA	0.383000													32	50					0	0	1	0	0
DAW1	164781	broad.mit.edu	37	2	228767756	228767756	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:228767756G>A	ENST00000373666.2	+	7	1215	c.579G>A	c.(577-579)gcG>gcA	p.A193A	DAW1_ENST00000545118.1_Silent_p.A178A|DAW1_ENST00000309931.2_Silent_p.A193A					dynein assembly factor with WDR repeat domains 1																		CATTGGTGGCGACTGGAAGTA	0.358000													16	69					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10428244	10428244	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:10428244C>T	ENST00000245503.5	-	34	5185	c.4801G>A	c.(4801-4803)Gag>Aag	p.E1601K	CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E1601K|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1601					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TGCATGGACTCCACGATTCTA	0.448000													56	188					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76262755	76262755	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:76262755C>T	ENST00000263187.3	+	1	189	c.85C>T	c.(85-87)Ccc>Tcc	p.P29S		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	29					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						ACCTCAGGGTCCCCGCTACAA	0.637000								Mismatch excision repair (MMR)					20	77					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27945257	27945257	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:27945257C>T	ENST00000435845.2	-	1	346	c.327G>A	c.(325-327)atG>atA	p.M109I	CYYR1_ENST00000400043.3_Start_Codon_SNP_p.M1I|CYYR1_ENST00000299340.4_Start_Codon_SNP_p.M1I			Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	1						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						TCGGAGCGTCCATCCAAGCCG	0.647000													44	65					0	0	1	0	0
ZNF746	155061	broad.mit.edu	37	7	149174025	149174025	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:149174025C>T	ENST00000340622.3	-	6	1106	c.826G>A	c.(826-828)Gcc>Acc	p.A276T	ZNF746_ENST00000458143.2_Missense_Mutation_p.A276T			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	276					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TCCGTGGAGGCTGCTGTGTTG	0.607000													68	215					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57738929	57738929	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:57738929G>A	ENST00000360716.3	+	7	1062	c.841G>A	c.(841-843)Gag>Aag	p.E281K	CCDC135_ENST00000394337.4_Missense_Mutation_p.E281K|CCDC135_ENST00000336825.8_Missense_Mutation_p.E216K			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	281						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						GCTGAGGGAGGAGGAGGAGCG	0.587000													16	36					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45127210	45127210	+	RNA	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:45127210G>A	ENST00000575173.1	-	0	418																											GAGACAGATGGAAAGACAACA	0.453000													31	124					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65253736	65253736	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:65253736G>A	ENST00000389722.3	-	15	3000	c.2947C>T	c.(2947-2949)Ctg>Ttg	p.L983L	SPTB_ENST00000542895.1_Silent_p.L983L|SPTB_ENST00000389720.3_Silent_p.L983L|SPTB_ENST00000389721.5_Silent_p.L983L|SPTB_ENST00000556626.1_Silent_p.L983L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	983					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TCCCGCCCCAGGTCTTTTGTG	0.602000													25	62					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237399	29237399	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:29237399C>T	ENST00000382535.3	+	2	1283	c.914C>T	c.(913-915)tCc>tTc	p.S305F	FOXG1_ENST00000313071.4_Missense_Mutation_p.S305F			P55316	FOXG1_HUMAN	forkhead box G1	305				RAGSLYWPMSPFLSLHHPR -> APAPSTGPCRPSCPCTTP (in Ref. 1; CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CGCGCCGGCTCCCTCTACTGG	0.701000													54	138					0	0	1	0	0
HAL	3034	broad.mit.edu	37	12	96371813	96371813	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:96371813G>A	ENST00000261208.3	-	18	1931	c.1563C>T	c.(1561-1563)tcC>tcT	p.S521S	HAL_ENST00000538703.1_Silent_p.S521S|HAL_ENST00000541929.1_Silent_p.S313S	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	521					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	TGGTGGAGAGGGAGTCAACAG	0.562000													14	62					0	0	1	0	0
KLF8	11279	broad.mit.edu	37	X	56296747	56296747	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:56296747C>T	ENST00000468660.1	+	5	1179	c.891C>T	c.(889-891)atC>atT	p.I297I	KLF8_ENST00000374928.3_Intron	NM_007250.4	NP_009181.2	O95600	KLF8_HUMAN	Kruppel-like factor 8	297					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(4)|large_intestine(6)|lung(5)|ovary(1)	16						ACCGCAGAATCCATACAGGTC	0.517000													15	13					0	0	1	0	0
OR2J2	26707	broad.mit.edu	37	6	29141959	29141959	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:29141959C>T	ENST00000377167.2	+	1	649	c.547C>T	c.(547-549)Cca>Tca	p.P183S		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CTGTGAAGTTCCAGCACTTCT	0.438000													66	186					0	0	1	0	0
TIMP2	7077	broad.mit.edu	37	17	76851849	76851849	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:76851849G>A	ENST00000262768.7	-	5	861	c.563C>T	c.(562-564)gCc>gTc	p.A188V	TIMP2_ENST00000585421.1_Missense_Mutation_p.A111V|RP11-323N12.5_ENST00000587434.1_RNA|TIMP2_ENST00000536189.2_Missense_Mutation_p.A111V|TIMP2_ENST00000586057.1_Missense_Mutation_p.A111V	NM_003255.4	NP_003246.1	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2	188							metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			GAAGAACTTGGCCTGGTGCCC	0.612000													34	87					0	0	1	0	0
ST8SIA5	29906	broad.mit.edu	37	18	44266136	44266136	+	Splice_Site	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:44266136C>T	ENST00000315087.7	-	5	1230		c.e5+1		ST8SIA5_ENST00000590497.1_Splice_Site|ST8SIA5_ENST00000538168.1_Splice_Site|ST8SIA5_ENST00000536490.1_Splice_Site	NM_013305.4	NP_037437.2	O15466	SIA8E_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5						glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane				kidney(1)|large_intestine(10)|lung(7)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	22						GTTTCTTTTACCGGAAGACGA	0.557000													22	79					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32261073	32261073	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:32261073C>T	ENST00000375015.4	-	26	1574	c.1374G>A	c.(1372-1374)aaG>aaA	p.K458K	C6orf10_ENST00000533191.1_Silent_p.K457K|C6orf10_ENST00000527965.1_Silent_p.K443K|C6orf10_ENST00000447241.2_Silent_p.K459K|C6orf10_ENST00000442822.2_Silent_p.K450K|C6orf10_ENST00000375007.4_Silent_p.K457K			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	459						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						CCTCAGTGTTCTTTACTTGGG	0.458000													105	270					0	0	1	0	0
MEI1	150365	broad.mit.edu	37	22	42114232	42114232	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr22:42114232C>T	ENST00000401548.3	+	6	727	c.687C>T	c.(685-687)tcC>tcT	p.S229S	MEI1_ENST00000300398.4_5'UTR|MEI1_ENST00000540833.1_5'UTR|MEI1_ENST00000400107.1_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	229							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TCTTCCTTTCCATCCTGGATG	0.463000													9	34					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13753186	13753186	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:13753186G>A	ENST00000202816.1	-	5	1332	c.1225C>T	c.(1225-1227)Cct>Tct	p.P409S		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						GCATCTTCAGGAATACTTAAT	0.338000													41	116					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92345554	92345554	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:92345554G>A	ENST00000377067.3	+	3	811	c.439G>A	c.(439-441)Gat>Aat	p.D147N		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	147						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GTTCTTCACTGATGTGGGGCT	0.408000													43	133					0	0	1	0	0
SERPINB6	5269	broad.mit.edu	37	6	2948603	2948603	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:2948603G>A	ENST00000380520.1	-	6	3054	c.1060C>T	c.(1060-1062)Ccc>Tcc	p.P354S	SERPINB6_ENST00000335686.5_Missense_Mutation_p.P354S|SERPINB6_ENST00000380529.1_Missense_Mutation_p.P354S|SERPINB6_ENST00000380539.1_Missense_Mutation_p.P354S|SERPINB6_ENST00000380524.1_Missense_Mutation_p.P354S|SERPINB6_ENST00000380546.3_Missense_Mutation_p.P354S			P35237	SPB6_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 6	354					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|stomach(1)|upper_aerodigestive_tract(2)	17	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	AAAAGGAAGGGGTGGTCGGCG	0.602000													22	86					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133748267	133748267	+	Missense_Mutation	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:133748267C>A	ENST00000318560.5	+	6	1309	c.928C>A	c.(928-930)Ccg>Acg	p.P310T		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	310	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CCGGGAGCCCCCGTTCTATAT	0.547000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								27	105					1.2476e-16	1.26904e-16	1	1	0
GHR	2690	broad.mit.edu	37	5	42695153	42695153	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:42695153G>A	ENST00000230882.4	+	5	591	c.401G>A	c.(400-402)gGt>gAt	p.G134D	GHR_ENST00000357703.3_Missense_Mutation_p.G112D|GHR_ENST00000537449.1_5'UTR	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	134					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AGCAATGGTGGTACAGTGGAT	0.373000													25	54					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6691438	6691438	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:6691438G>A	ENST00000309577.6	-	29	4627	c.4464C>T	c.(4462-4464)gtC>gtT	p.V1488V	CHD4_ENST00000544484.1_Silent_p.V1485V|RP5-940J5.6_ENST00000501075.2_RNA|CHD4_ENST00000544040.1_Silent_p.V1453V|CHD4_ENST00000357008.2_Silent_p.V1460V|CHD4_ENST00000540960.1_5'UTR			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1460					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TGAAAAGAGAGACATATGCCC	0.488000													25	63					0	0	1	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135095784	135095784	+	Silent	SNP	G	G	A	rs112980465		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:135095784G>A	ENST00000368563.2	-	16	2708	c.2352C>T	c.(2350-2352)acC>acT	p.T784T	TUBGCP2_ENST00000543663.1_Silent_p.T812T|TUBGCP2_ENST00000252936.3_Silent_p.T784T|TUBGCP2_ENST00000417178.2_Silent_p.T654T|TUBGCP2_ENST00000368562.1_Silent_p.T377T	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	784					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		GCCCCAGGACGGTGCTGTGCT	0.627000													14	22					0	0	1	0	0
HTR6	3362	broad.mit.edu	37	1	19992253	19992253	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:19992253C>T	ENST00000289753.1	+	1	474	c.7C>T	c.(7-9)Cca>Tca	p.P3S		NM_000871.1	NP_000862.1	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	3					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			endometrium(1)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CCTCATGGTCCCAGAGCCGGG	0.746000													13	36					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354860	45354860	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:45354860C>T	ENST00000359271.2	+	2	1435	c.1185C>T	c.(1183-1185)ctC>ctT	p.L395L		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	395						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				GCTCTGCCCTCCCTGGGCCCC	0.632000													23	58					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55782894	55782894	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr10:55782894G>A	ENST00000373965.2	-	20	2699	c.2305C>T	c.(2305-2307)Ctt>Ttt	p.L769F	PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.L740F|PCDH15_ENST00000395432.2_Missense_Mutation_p.L725F|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.L769F|PCDH15_ENST00000409834.1_Missense_Mutation_p.L373F|PCDH15_ENST00000395438.1_Missense_Mutation_p.L762F|PCDH15_ENST00000437009.1_Missense_Mutation_p.L691F|PCDH15_ENST00000395430.1_Missense_Mutation_p.L762F|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000373955.1_Missense_Mutation_p.L762F|PCDH15_ENST00000361849.3_Missense_Mutation_p.L762F|PCDH15_ENST00000414778.1_Missense_Mutation_p.L767F|PCDH15_ENST00000320301.6_Missense_Mutation_p.L762F	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	762	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ATACGAAAAAGATTATTAAAG	0.373000										HNSCC(58;0.16)			24	55					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211320	78211320	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:78211320C>T	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCTGCTTTTGCAGCCTCTCAC	0.587000													5	408					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	64011118	64011118	+	Missense_Mutation	SNP	G	G	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:64011118G>C	ENST00000324472.4	-	11	1367	c.1184C>G	c.(1183-1185)tCt>tGt	p.S395C		NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	395					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		ATAATAAGAAGATAAGTACAT	0.274000													5	35					0	0	1	0	0
ELMSAN1	91748	broad.mit.edu	37	14	74188089	74188089	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:74188089G>A	ENST00000286523.5	-	11	3630	c.2848C>T	c.(2848-2850)Caa>Taa	p.Q950*	ELMSAN1_ENST00000394071.2_Nonsense_Mutation_p.Q950*	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		tccttctcttggatctctggc	0.622000													17	40					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79743954	79743954	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:79743954C>T	ENST00000338008.5	+	7	3014	c.2834C>T	c.(2833-2835)cCa>cTa	p.P945L	ZFYVE16_ENST00000510158.1_Missense_Mutation_p.P945L|ZFYVE16_ENST00000505560.1_Missense_Mutation_p.P945L	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	945					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TCTCAGGTTCCATCAGTGGAA	0.378000													31	83					0	0	1	0	0
L2HGDH	79944	broad.mit.edu	37	14	50713960	50713960	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:50713960C>T	ENST00000267436.4	-	10	1605	c.1208G>A	c.(1207-1209)gGa>gAa	p.G403E	L2HGDH_ENST00000421284.3_Missense_Mutation_p.G403E|L2HGDH_ENST00000261699.4_Intron			Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase	403					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			kidney(1)|large_intestine(4)|lung(3)|ovary(2)	10	all_epithelial(31;0.000599)|Breast(41;0.0102)					GGCTCTTACTCCAGCTGGGCC	0.428000													15	34					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95653585	95653585	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:95653585G>A	ENST00000433389.2	+	1	229	c.39G>A	c.(37-39)ggG>ggA	p.G13G	ESRP1_ENST00000358397.5_Silent_p.G13G|ESRP1_ENST00000423620.2_Silent_p.G13G|ESRP1_ENST00000454170.2_Silent_p.G13G	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	13					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						TGCTTTTTGGGATCACTGCTG	0.582000													17	48					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179732800	179732800	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179732800G>T	ENST00000420890.2	-	16	2644	c.2527C>A	c.(2527-2529)Ctg>Atg	p.L843M	CCDC141_ENST00000295723.5_Missense_Mutation_p.L268M	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	268	Ig-like.						protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			GAAAGGGCCAGTCTGTGGAGA	0.517000													24	78					1.64293e-13	1.66544e-13	1	1	0
PARP8	79668	broad.mit.edu	37	5	50111326	50111326	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:50111326G>A	ENST00000281631.5	+	15	1794	c.1636G>A	c.(1636-1638)Gaa>Aaa	p.E546K	PARP8_ENST00000505697.2_Missense_Mutation_p.E546K|PARP8_ENST00000514067.2_Missense_Mutation_p.E546K|PARP8_ENST00000503750.2_Missense_Mutation_p.E546K|PARP8_ENST00000505554.1_Missense_Mutation_p.E525K|PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000514342.2_Missense_Mutation_p.E299K	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	546						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				AGTAATGAATGAAGCTGCTGA	0.373000													25	55					0	0	1	0	0
ZNF564	163050	broad.mit.edu	37	19	12638052	12638052	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:12638052G>T	ENST00000339282.7	-	4	1066	c.870C>A	c.(868-870)ttC>ttA	p.F290L	CTD-2192J16.20_ENST00000593682.1_3'UTR|ZNF709_ENST00000428311.1_Intron	NM_144976.3	NP_659413.1			zinc finger protein 564											endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						TGAAAGAAATGAAGGCCTTCC	0.393000													23	79					3.5997e-14	3.65527e-14	1	1	0
ABL1	25	broad.mit.edu	37	9	133748268	133748268	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:133748268C>T	ENST00000318560.5	+	6	1310	c.929C>T	c.(928-930)cCg>cTg	p.P310L		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	310	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CGGGAGCCCCCGTTCTATATC	0.552000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								28	104					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24924170	24924170	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:24924170C>T	ENST00000329468.2	+	1	3630	c.3156C>T	c.(3154-3156)ttC>ttT	p.F1052F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CTTCTGTTTTCCCATTTGGTC	0.552000													31	73					0	0	1	0	0
OR9K2	441639	broad.mit.edu	37	12	55524480	55524480	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:55524480C>T	ENST00000305377.5	+	1	1016	c.928C>T	c.(928-930)Cct>Tct	p.P310S		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						CATGTTGAATCCTTTGATTTA	0.358000													71	152					0	0	1	0	0
HSD17B12	51144	broad.mit.edu	37	11	43837931	43837931	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:43837931C>T	ENST00000278353.4	+	6	610	c.491C>T	c.(490-492)tCt>tTt	p.S164F	HSD17B12_ENST00000529261.1_3'UTR	NM_016142.2	NP_057226.1	Q53GQ0	DHB12_HUMAN	hydroxysteroid (17-beta) dehydrogenase 12	164					long-chain fatty-acyl-CoA biosynthetic process|steroid biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	estradiol 17-beta-dehydrogenase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity			endometrium(2)|large_intestine(4)|lung(4)	10						AATATTCTTTCTGTTTGTAAG	0.299000													16	63					0	0	1	0	0
SPIRE1	56907	broad.mit.edu	37	18	12506555	12506555	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:12506555G>A	ENST00000409402.4	-	6	1160	c.893C>T	c.(892-894)cCc>cTc	p.P298L	SPIRE1_ENST00000383356.2_Missense_Mutation_p.P139L|SPIRE1_ENST00000410092.3_Missense_Mutation_p.P298L|SPIRE1_ENST00000309836.5_Missense_Mutation_p.P101L|SPIRE1_ENST00000453447.2_Missense_Mutation_p.P178L	NM_001128626.1	NP_001122098.1	Q08AE8	SPIR1_HUMAN	spire-type actin nucleation factor 1	298						cytoskeleton|perinuclear region of cytoplasm	actin binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)	28						ATATTCAATGGGCAAAGGGTT	0.458000													62	175					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47954716	47954716	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:47954716C>T	ENST00000402813.3	-	3	352	c.210G>A	c.(208-210)atG>atA	p.M70I	CNGA1_ENST00000544810.1_Start_Codon_SNP_p.M1I|CNGA1_ENST00000514170.1_Start_Codon_SNP_p.M1I|CNGA1_ENST00000420489.2_Start_Codon_SNP_p.M1I|CNGA1_ENST00000358519.4_Start_Codon_SNP_p.M1I			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	1					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						TGGATAGTTTCATATCTGAGG	0.328000													12	45					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197313503	197313503	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:197313503G>A	ENST00000367400.3	+	3	880	c.745G>A	c.(745-747)Gac>Aac	p.D249N	CRB1_ENST00000535699.1_Missense_Mutation_p.D180N|CRB1_ENST00000367399.2_Intron|CRB1_ENST00000543483.1_5'UTR|CRB1_ENST00000538660.1_Missense_Mutation_p.D249N	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	249	EGF-like 6; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTATTTCTGCGACTGTGCCCC	0.483000													86	278					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10441093	10441093	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:10441093G>A	ENST00000245503.5	-	15	1860	c.1476C>T	c.(1474-1476)ttC>ttT	p.F492F	CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Silent_p.F492F|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Silent_p.F492F	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	492	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TGTGGTGGTTGAAAAACTGTT	0.468000													74	170					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116757492	116757492	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:116757492G>A	ENST00000331677.3	+	7	2305	c.1861G>A	c.(1861-1863)Gat>Aat	p.D621N	DSE_ENST00000452085.3_Missense_Mutation_p.D621N|DSE_ENST00000359564.2_Missense_Mutation_p.D621N|DSE_ENST00000537543.1_Missense_Mutation_p.D640N			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	621					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		CTGGATGGACGATACTGGCTA	0.483000													40	60					0	0	1	0	0
ZNF653	115950	broad.mit.edu	37	19	11594517	11594517	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:11594517G>A	ENST00000293771.5	-	9	1964	c.1828C>T	c.(1828-1830)Ccg>Tcg	p.P610S	CTC-398G3.6_ENST00000585656.1_Intron	NM_138783.3	NP_620138.2	Q96CK0	ZN653_HUMAN	zinc finger protein 653	610					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	17						TTGTGATCCGGGTGGCTTTTG	0.627000													15	57					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95603072	95603072	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:95603072G>A	ENST00000343958.4	-	2	2211	c.1988C>T	c.(1987-1989)tCc>tTc	p.S663F	FGD6_ENST00000549499.1_Missense_Mutation_p.S663F|FGD6_ENST00000546711.1_Missense_Mutation_p.S663F	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	663					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						CTCCCCACTGGAGAGGTGGCC	0.463000													49	150					0	0	1	0	0
LBP	3929	broad.mit.edu	37	20	36995416	36995416	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:36995416C>T	ENST00000217407.2	+	9	1086	c.925C>T	c.(925-927)Ccg>Tcg	p.P309S		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	309					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				GCTGCAGATACCGCCTGACTC	0.547000													23	115					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70526082	70526082	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr18:70526082C>T	ENST00000327305.6	-	4	1105	c.448G>A	c.(448-450)Gct>Act	p.A150T	NETO1_ENST00000299430.2_Missense_Mutation_p.A149T|NETO1_ENST00000583169.1_Missense_Mutation_p.A150T|NETO1_ENST00000397929.1_Missense_Mutation_p.A149T|NETO1_ENST00000580049.1_5'UTR	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	150	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TTGTATCGAGCTGAAAATCCC	0.323000													29	70					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44248500	44248500	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:44248500G>A	ENST00000262419.6	-	2	1480	c.1010C>T	c.(1009-1011)tCc>tTc	p.S337F	KANSL1_ENST00000572904.1_Missense_Mutation_p.S337F|KANSL1_ENST00000575318.1_Missense_Mutation_p.S337F|KANSL1_ENST00000574590.1_Missense_Mutation_p.S337F|KANSL1_ENST00000393476.3_5'UTR|KANSL1_ENST00000432791.1_Missense_Mutation_p.S337F	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	337						MLL1 complex	protein binding	p.S337Y(1)|p.S337C(1)									TGGTCTCAAGGATTCCAAGTT	0.493000													37	107					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205538409	205538409	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:205538409G>A	ENST00000367147.4	+	1	305	c.212G>A	c.(211-213)gGg>gAg	p.G71E	MFSD4_ENST00000536357.1_Missense_Mutation_p.G71E|MFSD4_ENST00000539267.1_Missense_Mutation_p.G71E	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	71					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			AGCGCCCTCGGGGGCGTCTTC	0.741000													3	14					0	0	1	0	0
RNF133	168433	broad.mit.edu	37	7	122338449	122338449	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:122338449G>A	ENST00000340112.2	-	1	761	c.524C>T	c.(523-525)gCc>gTc	p.A175V	CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000412584.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	175						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						CTCAACCACGGCTGTAATGAG	0.378000													48	140					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	63974589	63974589	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:63974589G>A	ENST00000324472.4	-	19	1936	c.1753C>T	c.(1753-1755)Cgt>Tgt	p.R585C	DPY19L2_ENST00000413230.2_Missense_Mutation_p.R32C	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	585					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TTCTCAAAACGAACTCTGCGA	0.358000													23	84					0	0	1	0	0
TMEM56	148534	broad.mit.edu	37	1	95616888	95616888	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:95616888C>T	ENST00000370203.4	+	5	603	c.312C>T	c.(310-312)tcC>tcT	p.S104S	RP11-57H12.6_ENST00000604534.1_Silent_p.S104S	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56	104	TLC.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		CAGATTTGTCCATTATAATTT	0.348000													26	80					0	0	1	0	0
SPANXN3	139067	broad.mit.edu	37	X	142596670	142596670	+	Missense_Mutation	SNP	A	A	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:142596670A>T	ENST00000370503.2	-	2	483	c.400T>A	c.(400-402)Tct>Act	p.S134T	GS1-256O22.5_ENST00000431432.1_RNA	NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	134										endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTGTGAAGATCCTTCAGAT	0.443000													41	51					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98850543	98850543	+	RNA	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:98850543C>A	ENST00000554295.1	-	0	380					NR_033801.1																						GGGTACCATACCTCAGGATCA	0.527000													5	20					3.59834e-05	3.61666e-05	1	1	0
RIMS2	9699	broad.mit.edu	37	8	104948833	104948833	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:104948833G>A	ENST00000507740.1	+	10	2042	c.1806G>A	c.(1804-1806)tgG>tgA	p.W602*	RIMS2_ENST00000436393.2_Nonsense_Mutation_p.W588*|RIMS2_ENST00000406091.3_Nonsense_Mutation_p.W810*|RIMS2_ENST00000262231.10_Nonsense_Mutation_p.W649*	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	872					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AACCCAAATGGAACCAAACAT	0.353000										HNSCC(12;0.0054)			93	90					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158256856	158256856	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:158256856G>A	ENST00000296526.7	+	10	1625	c.1300G>A	c.(1300-1302)Gaa>Aaa	p.E434K	GRIA2_ENST00000449365.1_Missense_Mutation_p.E387K|GRIA2_ENST00000393815.2_Missense_Mutation_p.E387K|GRIA2_ENST00000507898.1_Missense_Mutation_p.E387K|GRIA2_ENST00000264426.9_Missense_Mutation_p.E434K	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	434					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	GAAAAATCATGAAATGCTTGA	0.373000													20	61					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													4	245					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165175136	165175136	+	Missense_Mutation	SNP	G	G	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:165175136G>T	ENST00000342310.3	-	8	1335	c.953C>A	c.(952-954)cCa>cAa	p.P318Q	LMX1A_ENST00000367893.4_Missense_Mutation_p.P318Q|LMX1A_ENST00000294816.2_Missense_Mutation_p.P318Q|LMX1A_ENST00000489443.2_5'UTR	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	318						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CATCTGGGGTGGGGTGAGACC	0.572000													80	101					2.70532e-21	2.77085e-21	1	1	0
GRIA1	2890	broad.mit.edu	37	5	153077667	153077667	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:153077667G>A	ENST00000285900.5	+	9	1541	c.1198G>A	c.(1198-1200)Gat>Aat	p.D400N	GRIA1_ENST00000340592.5_Missense_Mutation_p.D400N|GRIA1_ENST00000518783.1_Missense_Mutation_p.D410N|GRIA1_ENST00000521843.2_Missense_Mutation_p.D331N|GRIA1_ENST00000518142.1_Missense_Mutation_p.D320N|GRIA1_ENST00000448073.4_Missense_Mutation_p.D410N	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	400					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGCTGGGGGCGATAATTCAAG	0.478000													22	63					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50247522	50247522	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:50247522G>A	ENST00000246801.3	-	8	1409	c.1327C>T	c.(1327-1329)Cgg>Tgg	p.R443W	TSKS_ENST00000358830.3_Missense_Mutation_p.R243W	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	443							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		TGGTGGGACCGATCCAGGTTC	0.592000													24	60					0	0	1	0	0
PTGR2	145482	broad.mit.edu	37	14	74340788	74340788	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:74340788C>T	ENST00000555661.1	+	4	364	c.219C>T	c.(217-219)gtC>gtT	p.V73V	RP5-1021I20.4_ENST00000553813.1_5'UTR|PTGR2_ENST00000267568.4_Silent_p.V73V|PTGR2_ENST00000554885.1_Silent_p.V49V|PTGR2_ENST00000555228.1_Silent_p.V73V			Q8N8N7	PTGR2_HUMAN	prostaglandin reductase 2	73					prostaglandin metabolic process		15-oxoprostaglandin 13-oxidase activity|zinc ion binding			NS(1)|large_intestine(3)|lung(2)|prostate(1)|skin(2)	9						TATCTCAAGTCGTTGATGGAG	0.363000													35	92					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215279277	215279277	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:215279277G>A	ENST00000312504.5	+	2	1162	c.360G>A	c.(358-360)ggG>ggA	p.G120G	AC107218.3_ENST00000412896.1_RNA|AC107218.3_ENST00000437883.1_RNA|VWC2L_ENST00000427124.1_Silent_p.G120G	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	120	VWFC 2.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						AATATCACGGGAAAAATTACA	0.358000													11	47					0	0	1	0	0
SLC37A4	2542	broad.mit.edu	37	11	118899985	118899985	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:118899985G>A	ENST00000545985.1	-	3	851	c.95C>T	c.(94-96)tCc>tTc	p.S32F	SLC37A4_ENST00000330775.7_Missense_Mutation_p.S32F|SLC37A4_ENST00000538950.1_Intron|SLC37A4_ENST00000525102.1_5'UTR|SLC37A4_ENST00000357590.5_Missense_Mutation_p.S32F	NM_001164277.1|NM_001467.5	NP_001157749.1|NP_001458.1	O43826	G6PT1_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 4	32					glucose homeostasis|glucose metabolic process	endoplasmic reticulum membrane|integral to endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphate transmembrane transporter activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	6	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		CATGACAAAGGAGAAGGTCTT	0.517000													6	32					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51897853	51897853	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:51897853C>T	ENST00000453097.2	+	23	3339	c.3122C>T	c.(3121-3123)cCc>cTc	p.P1041L		NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	1041					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		GACAAGTTTCCCTTAGAGAGC	0.393000													5	12					0	0	1	0	0
MT-ND6	4541	broad.mit.edu	37	MT	14380	14380	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrM:14380C>T	ENST00000361681.2	-	1	293	c.294G>A	c.(292-294)atG>atA	p.M98I						mitochondrially encoded NADH dehydrogenase 6											breast(1)|endometrium(10)|kidney(17)|urinary_tract(1)	29						AATCCTACCTCCATCGCTAAC	0.473000													45	49					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420566	53420566	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr13:53420566C>T	ENST00000377942.3	-	1	2209	c.2006G>A	c.(2005-2007)gGg>gAg	p.G669E	PCDH8_ENST00000338862.4_Missense_Mutation_p.G669E	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	669	Cadherin 6.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CAGTATCTCCCCCGTGCGGCG	0.716000													7	32					0	0	1	0	0
MSL3P1	151507	broad.mit.edu	37	2	234774970	234774970	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:234774970C>T	ENST00000438684.1	-	0	1144					NR_024322.1																						GACAAACAATCGCAGCAAATG	0.433000													30	83					0	0	1	0	0
TTPAL	79183	broad.mit.edu	37	20	43108900	43108900	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:43108900C>T	ENST00000372904.3	+	3	404	c.261C>T	c.(259-261)gcC>gcT	p.A87A	TTPAL_ENST00000262605.4_Silent_p.A87A|TTPAL_ENST00000372906.2_Silent_p.A87A	NM_024331.4	NP_077307.2	Q9BTX7	TTPAL_HUMAN	tocopherol (alpha) transfer protein-like	87						intracellular	transporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|skin(5)	18						TCCTCCGAGCCCGCAAGTTTG	0.572000													18	52					0	0	1	0	0
OR4D2	124538	broad.mit.edu	37	17	56247706	56247706	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:56247706G>A	ENST00000545221.1	+	1	690	c.690G>A	c.(688-690)ggG>ggA	p.G230G		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						CACATCCAGGGGAGGCAAGAA	0.532000													38	89					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459899	66459899	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:66459899C>T	ENST00000424345.1	+	0	159																											agtgtctggacattaaaatct	0.378000													4	16					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793848	65793848	+	Translation_Start_Site	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:65793848C>T	ENST00000312106.5	-	1	140	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	1					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						AGTTTTGATCCATGACTGTGC	0.537000													34	113					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241031931	241031931	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:241031931G>A	ENST00000366565.1	-	9	946	c.565C>T	c.(565-567)Ctt>Ttt	p.L189F	RGS7_ENST00000401882.1_Missense_Mutation_p.L136F|RGS7_ENST00000331110.7_Missense_Mutation_p.L163F|RGS7_ENST00000348120.2_Missense_Mutation_p.L136F|RGS7_ENST00000407727.1_Missense_Mutation_p.L189F|RGS7_ENST00000366563.1_Missense_Mutation_p.L189F|RGS7_ENST00000366562.4_Missense_Mutation_p.L189F|RGS7_ENST00000446183.2_Missense_Mutation_p.L105F|RGS7_ENST00000366564.1_Missense_Mutation_p.L189F	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	189					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TGGCTGTCAAGGATCTTCCTT	0.458000													65	106					0	0	1	0	0
DCTN4	51164	broad.mit.edu	37	5	150133177	150133177	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:150133177G>A	ENST00000447998.2	-	3	364	c.249C>T	c.(247-249)ctC>ctT	p.L83L	DCTN4_ENST00000424236.1_Silent_p.L26L|DCTN4_ENST00000446090.2_Silent_p.L83L|DCTN4_ENST00000521093.1_5'UTR	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)	83						centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCGAGTAGAGAGGGTGTGCA	0.468000													11	31					0	0	1	0	0
VPS54	51542	broad.mit.edu	37	2	64174578	64174578	+	Missense_Mutation	SNP	A	A	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:64174578A>C	ENST00000272322.4	-	9	1338	c.1184T>G	c.(1183-1185)cTt>cGt	p.L395R	VPS54_ENST00000409558.3_Missense_Mutation_p.L383R|VPS54_ENST00000354504.3_Intron	NM_016516.2	NP_057600.2	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	395					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						TAAAAAATTAAGCTTTCTTTG	0.234000													12	35					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57549949	57549949	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:57549949C>T	ENST00000243077.3	+	9	1766	c.1300C>T	c.(1300-1302)Cag>Tag	p.Q434*		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	434					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGCCAATGCCCAGCAGAAGAC	0.547000													34	133					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													7	88					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179549403	179549403	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:179549403G>A	ENST00000589042.1	-	131	32852	c.32628C>T	c.(32626-32628)ctC>ctT	p.L10876L	TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Silent_p.L9632L|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Silent_p.L10559L|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10559	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTGGCTGGGAGAGGTTCTT	0.413000													17	55					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145847964	145847964	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:145847964C>T	ENST00000296702.5	+	6	1234	c.1196C>T	c.(1195-1197)aCc>aTc	p.T399I	TCERG1_ENST00000394421.2_Intron	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	399					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCACCAAGACCGGTAATTTT	0.388000													21	57					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110763663	110763663	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:110763663G>A	ENST00000451085.1	+	4	1881	c.835G>A	c.(835-837)Gat>Aat	p.D279N	IMMP2L_ENST00000450877.1_Intron|LRRN3_ENST00000422987.3_Missense_Mutation_p.D279N|LRRN3_ENST00000308478.5_Missense_Mutation_p.D279N|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000331762.3_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	279						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ACGAAGGGGTGATTTTAGCAA	0.338000													35	94					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348842	30348842	+	Missense_Mutation	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:30348842A>G	ENST00000327564.7	+	1	819	c.758A>G	c.(757-759)tAt>tGt	p.Y253C	LRRC37B_ENST00000394713.3_Missense_Mutation_p.Y226C|LRRC37B_ENST00000543378.2_Missense_Mutation_p.Y144C|LRRC37B_ENST00000341671.7_Missense_Mutation_p.Y226C|LRRC37B_ENST00000584368.1_Missense_Mutation_p.Y238C			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	226						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				CCAGATGATTATTTGAGTATG	0.493000													64	171					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135431406	135431406	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chrX:135431406C>T	ENST00000394143.1	+	6	5832	c.5541C>T	c.(5539-5541)atC>atT	p.I1847I	GPR112_ENST00000412101.1_Silent_p.I1642I|GPR112_ENST00000370652.1_Silent_p.I1847I|GPR112_ENST00000287534.4_Silent_p.I1784I|GPR112_ENST00000394141.1_Silent_p.I1642I	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1847					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AAGCTGAGATCTCTACTCCAA	0.443000													31	51					0	0	1	0	0
KCNA7	3743	broad.mit.edu	37	19	49574007	49574007	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:49574007G>A	ENST00000221444.1	-	2	1039	c.684C>T	c.(682-684)ctC>ctT	p.L228L		NM_031886.2	NP_114092.2	Q96RP8	KCNA7_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 7	228						voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|skin(2)	11		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000397)|OV - Ovarian serous cystadenocarcinoma(262;0.000519)|GBM - Glioblastoma multiforme(486;0.00541)|Epithelial(262;0.0441)		GACAGACCAGGAGGCGTACCA	0.527000													35	68					0	0	1	0	0
MAP3K2	10746	broad.mit.edu	37	2	128084364	128084364	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:128084364G>A	ENST00000409947.1	-	8	778	c.496C>T	c.(496-498)Ccc>Tcc	p.P166S	MAP3K2_ENST00000344908.5_Missense_Mutation_p.P166S			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	166					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		TAACCTGGGGGAGGAGAACTT	0.393000													18	37					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4944897	4944897	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:4944897G>A	ENST00000321961.2	-	1	740	c.673C>T	c.(673-675)Cgc>Tgc	p.R225C	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCACGGTGCGAAGGATGAGG	0.537000													24	82					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7318902	7318902	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:7318902G>A	ENST00000302926.2	+	6	1183	c.1110G>A	c.(1108-1110)caG>caA	p.Q370Q	NLGN2_ENST00000575301.1_Silent_p.Q370Q	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	370					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				TCATGCAGCAGGGAGAATTCC	0.607000													37	136					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110100173	110100173	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:110100173G>A	ENST00000518632.1	+	2	783	c.432G>A	c.(430-432)aaG>aaA	p.K144K	TRHR_ENST00000311762.2_Silent_p.K144K			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	144						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GAGCCAAAAAGATTATCATCT	0.403000													24	151					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													6	167					0	0	1	0	0
OR10G9	219870	broad.mit.edu	37	11	123894487	123894487	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr11:123894487C>T	ENST00000375024.1	+	1	768	c.768C>T	c.(766-768)ttC>ttT	p.F256F		NM_001001953.1	NP_001001953.1	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G, member 9	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(33)|prostate(2)|skin(4)|stomach(8)|urinary_tract(1)	61		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCTGTGTTTTCATTTACCTGA	0.542000													50	150					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064001	9064001	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:9064001G>A	ENST00000397910.4	-	3	23648	c.23445C>T	c.(23443-23445)ttC>ttT	p.F7815F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7817	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TAGTCTCAAGGAAGGCAGGAG	0.527000													56	148					0	0	1	0	0
UBXN10	127733	broad.mit.edu	37	1	20517560	20517560	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:20517560C>T	ENST00000375099.3	+	2	590	c.506C>T	c.(505-507)gCc>gTc	p.A169V		NM_152376.3	NP_689589.1	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	169										endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|skin(2)	14						CGAGCTTGTGCCGTGGAGAGG	0.532000													4	119					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218682927	218682927	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:218682927C>T	ENST00000171887.4	-	24	4268	c.3816G>A	c.(3814-3816)ctG>ctA	p.L1272L	TNS1_ENST00000430930.1_Silent_p.L1251L|TNS1_ENST00000419504.1_Silent_p.L1259L	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1272						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGTGCCGGCCCAGGCTGGGAC	0.682000													16	36					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38997158	38997158	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:38997158G>A	ENST00000355481.4	+	56	8795	c.8664G>A	c.(8662-8664)cgG>cgA	p.R2888R	RYR1_ENST00000360985.3_Silent_p.R2888R|RYR1_ENST00000359596.3_Silent_p.R2888R	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2888	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGTGGGGACGGAagaagaagc	0.587000													21	67					0	0	1	0	0
KLK12	43849	broad.mit.edu	37	19	51535267	51535267	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:51535267C>T	ENST00000525263.1	-	3	441	c.322G>A	c.(322-324)Gac>Aac	p.D108N	KLK12_ENST00000250351.4_Missense_Mutation_p.D108N|KLK12_ENST00000529888.1_Intron|KLK12_ENST00000250352.11_Intron|CTC-518B2.9_ENST00000594910.1_RNA|KLK12_ENST00000319590.4_Missense_Mutation_p.D108N			Q9UKR0	KLK12_HUMAN	kallikrein-related peptidase 12	108	Peptidase S1.				proteolysis	extracellular region|soluble fraction	serine-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	12		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00399)		AGCCGGAGGTCGTGCTCGTGG	0.677000													13	47					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160851925	160851925	+	Missense_Mutation	SNP	C	C	T	rs151006223	byFrequency	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:160851925C>T	ENST00000326245.3	-	4	342	c.227G>A	c.(226-228)gGt>gAt	p.G76D		NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	76	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCAGCCGCCACCCCCAGAGGT	0.592000													21	106					0	0	1	0	0
BATF3	55509	broad.mit.edu	37	1	212860169	212860169	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:212860169G>A	ENST00000243440.1	-	3	570	c.348C>T	c.(346-348)ccC>ccT	p.P116P	BATF3_ENST00000478275.1_5'UTR	NM_018664.2	NP_061134.1	Q9NR55	BATF3_HUMAN	basic leucine zipper transcription factor, ATF-like 3	116					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(2)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0046)|all cancers(67;0.00785)|GBM - Glioblastoma multiforme(131;0.0731)|Epithelial(68;0.0781)		GGTCCGGCCGGGGAGGCACTG	0.612000													30	113					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141722186	141722186	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:141722186G>A	ENST00000475668.2	+	7	883	c.829G>A	c.(829-831)Gat>Aat	p.D277N	MGAM_ENST00000549489.2_Missense_Mutation_p.D277N			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	277	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTATCGGCATGATATGAATTG	0.488000													82	76					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89938513	89938513	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:89938513G>A	ENST00000405460.2	+	12	2397	c.2301G>A	c.(2299-2301)ttG>ttA	p.L767L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	767					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TAATTATTTTGGAAAATGATG	0.408000													53	127					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110460428	110460428	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:110460428G>A	ENST00000378402.5	+	39	5937	c.5833G>A	c.(5833-5835)Gaa>Aaa	p.E1945K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1945	IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGAGATCTTGGAAATCTCCGT	0.388000										HNSCC(38;0.096)			11	43					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43384943	43384943	+	Silent	SNP	A	A	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:43384943A>T	ENST00000372851.3	-	6	708	c.642T>A	c.(640-642)ggT>ggA	p.G214G	RIMS4_ENST00000541604.2_Silent_p.G215G	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	214	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				CGCGAGCCACACCCATGAACT	0.627000													8	42					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404752	20404752	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:20404752G>A	ENST00000285600.4	+	1	986	c.927G>A	c.(925-927)tgG>tgA	p.W309*		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TGAACTCCTGGAAAAACTAGG	0.438000													17	82					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82586136	82586136	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:82586136G>A	ENST00000423517.2	-	5	4470	c.4133C>T	c.(4132-4134)cCa>cTa	p.P1378L	PCLO_ENST00000333891.8_Missense_Mutation_p.P1378L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1309					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AATAAGACTTGGAATTTCACC	0.448000													20	46					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110437354	110437354	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:110437354G>A	ENST00000378402.5	+	24	2842	c.2738G>A	c.(2737-2739)gGa>gAa	p.G913E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	913					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTCTACAGAGGAAATAATTGG	0.338000										HNSCC(38;0.096)			32	26					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197024898	197024898	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:197024898G>A	ENST00000367412.1	-	8	1344	c.1301C>T	c.(1300-1302)tCa>tTa	p.S434L		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	434	Sushi 7.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						AGATATTTTTGATCCCCTCAG	0.413000													55	101					0	0	1	0	0
BFSP2	8419	broad.mit.edu	37	3	133191246	133191246	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:133191246C>T	ENST00000302334.2	+	6	1170	c.1081C>T	c.(1081-1083)Cag>Tag	p.Q361*	BFSP2_ENST00000511434.1_3'UTR	NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	361	Rod.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						CATGGAGCTCCAGAACCTGGG	0.642000													18	46					0	0	1	0	0
WDR38	401551	broad.mit.edu	37	9	127618829	127618829	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:127618829G>A	ENST00000373574.1	+	6	624	c.568G>A	c.(568-570)Gga>Aga	p.G190R		NM_001045476.1|NM_001276374.1	NP_001038941.1|NP_001263303.1	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	190										breast(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						GGCGCTAGAGGGACACAGTGC	0.637000													11	35					0	0	1	0	0
SPACA4	171169	broad.mit.edu	37	19	49110327	49110327	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:49110327C>T	ENST00000321762.1	+	1	328	c.92C>T	c.(91-93)tCc>tTc	p.S31F	FAM83E_ENST00000263266.3_Intron	NM_133498.2	NP_598005.1	Q8TDM5	SACA4_HUMAN	sperm acrosome associated 4	31	UPAR/Ly6 1.				cell adhesion	acrosomal vesicle|anchored to membrane|plasma membrane				central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	5		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		CTCACCGACTCCATGCAGTGT	0.637000													47	142					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42042667	42042667	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:42042667G>A	ENST00000220809.4	-	7	819	c.563C>T	c.(562-564)cCc>cTc	p.P188L	PLAT_ENST00000270189.6_Missense_Mutation_p.P188L|PLAT_ENST00000352041.3_Missense_Mutation_p.P142L|PLAT_ENST00000524009.1_Intron|PLAT_ENST00000429089.2_Missense_Mutation_p.P188L|PLAT_ENST00000429710.2_Intron|PLAT_ENST00000519510.1_Missense_Mutation_p.P125L	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	188	Kringle 1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GTAGCACCAGGGCTTTGAGTC	0.547000													15	63					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27861295	27861295	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr17:27861295C>T	ENST00000261716.3	+	19	3040	c.2521C>T	c.(2521-2523)Cgg>Tgg	p.R841W	TAOK1_ENST00000536202.1_Missense_Mutation_p.R693W	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	841					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			GGTCTCCCTCCGGAGGGCACT	0.408000													20	41					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459899	66459899	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr9:66459899C>T	ENST00000424345.1	+	0	159																											agtgtctggacattaaaatct	0.378000													4	16					0	0	1	0	0
F2RL3	9002	broad.mit.edu	37	19	17001362	17001362	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr19:17001362C>T	ENST00000248076.3	+	2	1418	c.1088C>T	c.(1087-1089)aCc>aTc	p.T363I		NM_003950.2	NP_003941.2	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	363					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						CCGGGGGACACCGTGGCCTCC	0.637000													6	18					0	0	1	0	0
HOXA6	3203	broad.mit.edu	37	7	27187306	27187306	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr7:27187306G>A	ENST00000222728.3	-	1	87	c.63C>T	c.(61-63)ttC>ttT	p.F21F	HOXA-AS3_ENST00000521197.1_RNA|HOXA-AS3_ENST00000521231.1_RNA|HOXA-AS3_ENST00000518947.2_RNA|HOXA3_ENST00000467897.2_Intron|HOXA-AS3_ENST00000518848.1_RNA|HOXA6_ENST00000521478.1_Intron	NM_024014.3	NP_076919.1	P31267	HXA6_HUMAN	homeobox A6	21						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|lung(3)|ovary(1)	10						GCTGGCCCAAGAAGGAGTCCT	0.607000													19	65					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211320	78211320	+	RNA	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr15:78211320C>T	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCTGCTTTTGCAGCCTCTCAC	0.587000													5	408					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132999853	132999853	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr8:132999853G>A	ENST00000254624.5	+	18	2194	c.1969G>A	c.(1969-1971)Gat>Aat	p.D657N	EFR3A_ENST00000334503.4_Missense_Mutation_p.D657N|EFR3A_ENST00000519656.1_Missense_Mutation_p.D621N	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	657						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			GCATGAAAAAGATTTGTACTT	0.358000													15	17					0	0	1	0	0
UBXN10	127733	broad.mit.edu	37	1	20517560	20517560	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:20517560C>T	ENST00000375099.3	+	2	590	c.506C>T	c.(505-507)gCc>gTc	p.A169V		NM_152376.3	NP_689589.1	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	169										endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|skin(2)	14						CGAGCTTGTGCCGTGGAGAGG	0.532000													4	119					0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	G	A	rs143435240	byFrequency	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chrX:51076024G>A	ENST00000376006.3	+	2	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_ENST00000356450.2_Silent_p.E69E	NM_153183.2	NP_694853.1	Q8NFP7	NUD10_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 10	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(8)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000													3	41					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37740711	37740711	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr9:37740711G>A	ENST00000539465.1	+	15	2779	c.2186G>A	c.(2185-2187)cGg>cAg	p.R729Q	FRMPD1_ENST00000536622.1_Missense_Mutation_p.R551Q|FRMPD1_ENST00000541302.1_Missense_Mutation_p.R598Q|RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Missense_Mutation_p.R729Q			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	729						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		ACAGCTTCCCGGCAAGGGGGA	0.647000													16	53					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119749443	119749443	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:119749443G>A	ENST00000541757.1	+	15	1345	c.965G>A	c.(964-966)gGa>gAa	p.G322E	MARCO_ENST00000327097.4_Missense_Mutation_p.G400E			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	400	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity	p.G400V(2)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						GGAGACCAGGGAGTGAAAGGT	0.547000													5	14					0	0	1	0	0
ALDH3B1	221	broad.mit.edu	37	11	67786692	67786692	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr11:67786692C>T	ENST00000539229.1	+	6	561	c.445C>T	c.(445-447)Ctg>Ttg	p.L149L	ALDH3B1_ENST00000342456.6_Silent_p.L113L|ALDH3B1_ENST00000316367.6_Silent_p.L149L|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000007633.8_Silent_p.L149L	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	150					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	CGAGAAGATCCTGGCCGAGGT	0.637000													3	32					0	0	1	0	0
SPATA17	128153	broad.mit.edu	37	1	217947744	217947744	+	Silent	SNP	A	A	G			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:217947744A>G	ENST00000366933.4	+	7	643	c.588A>G	c.(586-588)gcA>gcG	p.A196A		NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	196						cytoplasm	calmodulin binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TACAGAAGGCAAAGCCTTTAA	0.433000													34	141					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25168432	25168432	+	RNA	SNP	T	T	C	rs149337771	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr13:25168432T>C	ENST00000453498.1	+	0	1104																											TTGAAACAGCTGGTGTATTAA	0.373000													3	32					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218682926	218682926	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:218682926C>T	ENST00000171887.4	-	24	4269	c.3817G>A	c.(3817-3819)Ggc>Agc	p.G1273S	TNS1_ENST00000430930.1_Missense_Mutation_p.G1252S|TNS1_ENST00000419504.1_Missense_Mutation_p.G1260S	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1273						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGGTGCCGGCCCAGGCTGGGA	0.682000													16	35					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66466210	66466210	+	RNA	SNP	C	C	T	rs147345298	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr9:66466210C>T	ENST00000424345.1	+	0	843																											acctgagtgactctctcctag	0.438000													3	21					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124358289	124358289	+	Splice_Site	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr10:124358289G>A	ENST00000338354.3	+	26	3062		c.e26-1		DMBT1_ENST00000344338.3_Splice_Site|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000368956.2_Splice_Site|DMBT1_ENST00000330163.4_Splice_Site|DMBT1_ENST00000368909.3_Splice_Site|DMBT1_ENST00000368955.3_Splice_Site			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1						epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTCCCCTGTAGGATCTGAATC	0.527000													7	443					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218682927	218682927	+	Silent	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:218682927C>T	ENST00000171887.4	-	24	4268	c.3816G>A	c.(3814-3816)ctG>ctA	p.L1272L	TNS1_ENST00000430930.1_Silent_p.L1251L|TNS1_ENST00000419504.1_Silent_p.L1259L	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1272						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGTGCCGGCCCAGGCTGGGAC	0.682000													16	36					0	0	1	0	0
HSD17B12	51144	broad.mit.edu	37	11	43837931	43837931	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr11:43837931C>T	ENST00000278353.4	+	6	610	c.491C>T	c.(490-492)tCt>tTt	p.S164F	HSD17B12_ENST00000529261.1_3'UTR	NM_016142.2	NP_057226.1	Q53GQ0	DHB12_HUMAN	hydroxysteroid (17-beta) dehydrogenase 12	164					long-chain fatty-acyl-CoA biosynthetic process|steroid biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	estradiol 17-beta-dehydrogenase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity			endometrium(2)|large_intestine(4)|lung(4)	10						AATATTCTTTCTGTTTGTAAG	0.299000													16	63					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128392735	128392735	+	Silent	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:128392735G>A	ENST00000389524.4	+	42	5732	c.5679G>A	c.(5677-5679)cgG>cgA	p.R1893R	MYO7B_ENST00000428314.1_Silent_p.R1892R|MYO7B_ENST00000409816.2_Silent_p.R1892R|MYO7B_ENST00000409090.1_Silent_p.R745R			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1892	FERM 2.|MyTH4 3.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ACTTCATGCGGAAATTGTGGC	0.627000													8	25					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459884	66459884	+	RNA	SNP	T	T	G	rs139166660	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr9:66459884T>G	ENST00000424345.1	+	0	144																											tagtagatgttcttcagtgtc	0.368000													6	17					0	0	1	0	0
LOC101930452	101930452	broad.mit.edu	37	12	9548908	9548908	+	RNA	SNP	G	G	C	rs78201839	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr12:9548908G>C	ENST00000567749.1	+	0	3083																											GACCTGCAAAGCCAGGCAGAA	0.542000													4	11					0	0	1	0	0
CTTN	2017	broad.mit.edu	37	11	70279378	70279378	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr11:70279378C>T	ENST00000346329.3	+	15	1635	c.1327C>T	c.(1327-1329)Ccc>Tcc	p.P443S	CTTN_ENST00000376561.3_Missense_Mutation_p.P443S|CTTN_ENST00000538675.1_Missense_Mutation_p.P164S|CTTN_ENST00000301843.8_Missense_Mutation_p.P480S	NM_138565.2	NP_612632.1	Q14247	SRC8_HUMAN	cortactin	480						cell cortex|cytoskeleton|lamellipodium|ruffle|soluble fraction	protein binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	31			BRCA - Breast invasive adenocarcinoma(2;4.34e-41)|LUSC - Lung squamous cell carcinoma(11;1.51e-13)|STAD - Stomach adenocarcinoma(18;0.0513)	Lung(977;0.0234)|LUSC - Lung squamous cell carcinoma(976;0.133)		GGGCCACTATCCCGCAGGTAC	0.687000													12	29					0	0	1	0	0
SLC9A7P1	121456	broad.mit.edu	37	12	98850543	98850543	+	RNA	SNP	C	C	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr12:98850543C>A	ENST00000554295.1	-	0	380					NR_033801.1																						GGGTACCATACCTCAGGATCA	0.527000													5	20					3.59834e-05	3.7619e-05	1	1	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000377425.4_Intron			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													4	130					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57075434	57075434	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr16:57075434C>T	ENST00000436936.1	+	18	3202	c.2977C>T	c.(2977-2979)Cag>Tag	p.Q993*	NLRC5_ENST00000262510.6_Nonsense_Mutation_p.Q993*|NLRC5_ENST00000308149.7_Nonsense_Mutation_p.Q993*|NLRC5_ENST00000539144.1_Nonsense_Mutation_p.Q993*			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	993					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GCACCTAGAGCAGCTCTGCAA	0.582000													14	60					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205538409	205538409	+	Missense_Mutation	SNP	G	G	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:205538409G>A	ENST00000367147.4	+	1	305	c.212G>A	c.(211-213)gGg>gAg	p.G71E	MFSD4_ENST00000539267.1_Missense_Mutation_p.G71E|MFSD4_ENST00000536357.1_Missense_Mutation_p.G71E	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	71					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			AGCGCCCTCGGGGGCGTCTTC	0.741000													3	14					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99662020	99662020	+	Missense_Mutation	SNP	C	C	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr7:99662020C>T	ENST00000292450.4	+	4	1366	c.1202C>T	c.(1201-1203)gCg>gTg	p.A401V	ZSCAN21_ENST00000543588.1_Missense_Mutation_p.R367W|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.R367W|ZNF3_ENST00000413658.2_3'UTR	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	401					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AGTCAGCATGCGGGCCTCAGC	0.522000													4	173					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16960045	16960045	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:16960045delT	ENST00000412962.1	-	0	16																											atacaaaaaattagccaggtg	0.537													2	4	---	---	---	---					
LINC01355	100996511	broad.mit.edu	37	1	23611611	23611612	+	RNA	INS	-	-	TGAG	rs58087683	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:23611611_23611612insTGAG	ENST00000566551.1	-	0	1633_1634																											gcctggaggactgagactcagt	0.480													4	3	---	---	---	---					
SLC2A1-AS1	440584	broad.mit.edu	37	1	43433830	43433831	+	RNA	INS	-	-	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:43433830_43433831insA	ENST00000431759.1	+	0	529					NR_033967.1																						ctccatcccagaaaaaaaaaaa	0.436													2	4	---	---	---	---					
IPP	3652	broad.mit.edu	37	1	46184897	46184898	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:46184897_46184898delAC	ENST00000396478.3	-	6	1265_1266	c.1163_1164delGT	c.(1162-1164)tfs	p.C388fs		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	388						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TAGCCCCATAACACACACACAC	0.347													7	102	---	---	---	---					
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121140484	121140485	+	RNA	DEL	AA	AA	-	rs77501191		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:121140484_121140485delAA	ENST00000417218.1	+	0	551																											tgatggggttaaaaaaaaaaaa	0.446													5	11	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142663276	142663277	+	RNA	DEL	AA	AA	-	rs61807144		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:142663276_142663277delAA	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							CATTTTTAGCAAAGTTGTTGCA	0.540													3	4	---	---	---	---					
LINC00970	101978719	broad.mit.edu	37	1	168878973	168878973	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:168878973delA	ENST00000366408.3	-	0	209																											aacttgcaccaaaaaaaagtc	0.453													2	4	---	---	---	---					
RPS10P7	376693	broad.mit.edu	37	1	201493458	201493458	+	RNA	DEL	G	G	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr1:201493458delG	ENST00000441932.1	+	0	1948				RP11-134G8.7_ENST00000454651.1_RNA	NR_026667.1																						aatggagccaggtgtggtgac	0.423													2	4	---	---	---	---					
AC105393.1	0	broad.mit.edu	37	2	410021	410023	+	RNA	DEL	CAC	CAC	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:410021_410023delCAC	ENST00000431911.1	+	0	186																											tcgtcatccacaccaccatccac	0.527													4	3	---	---	---	---					
AC105399.2	0	broad.mit.edu	37	2	78019880	78019880	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:78019880delT	ENST00000422418.1	+	0	130																											TAAAAATTCCTTTTTTTTTTT	0.393													3	3	---	---	---	---					
LOC101927795	101927795	broad.mit.edu	37	2	201670645	201670645	+	RNA	DEL	T	T	-	rs76218291		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr2:201670645delT	ENST00000447972.3	-	0	386																											cttcttcttcttttttttttc	0.453													3	3	---	---	---	---					
AC026188.1	0	broad.mit.edu	37	3	3483705	3483706	+	RNA	DEL	CA	CA	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:3483705_3483706delCA	ENST00000455703.1	-	0	59																											aatacacatgcacacacacaca	0.356													2	4	---	---	---	---					
AC133680.1	0	broad.mit.edu	37	3	24827973	24827974	+	RNA	DEL	TG	TG	-	rs6147734		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:24827973_24827974delTG	ENST00000455576.1	+	0	132																											AATAAGATCAtgtgtgtgtgtg	0.421													2	4	---	---	---	---					
SUCLG2-AS1	101927111	broad.mit.edu	37	3	67834498	67834500	+	RNA	DEL	GCT	GCT	-	rs34065577		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:67834498_67834500delGCT	ENST00000482677.1	+	0	615																											AGTTACGCAGGCTGCTTTGTGCC	0.399													3	4	---	---	---	---					
ECT2	1894	broad.mit.edu	37	3	172491750	172491752	+	In_Frame_Del	DEL	GAG	GAG	-	rs142499943		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr3:172491750_172491752delGAG	ENST00000417960.1	+	14	1867_1869	c.1390_1392delGAG	c.(1390-1392)del	p.E465del	ECT2_ENST00000427830.1_In_Frame_Del_p.E466del|ECT2_ENST00000441497.2_In_Frame_Del_p.E466del|ECT2_ENST00000392692.3_In_Frame_Del_p.E497del|ECT2_ENST00000540509.1_In_Frame_Del_p.E497del|ECT2_ENST00000232458.5_In_Frame_Del_p.E466del	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	466	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CCTTGCACCAGAGGAGATTAAGA	0.340													22	66	---	---	---	---					
TACC3	10460	broad.mit.edu	37	4	1742685	1742688	+	Frame_Shift_Del	DEL	AGAA	AGAA	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:1742685_1742688delAGAA	ENST00000313288.4	+	13	2301_2304	c.2195_2198delAGAA	c.(2194-2199)cafs	p.QK732fs		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	732						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			TTTGAGAAACAGAAAGAGGTGATC	0.515													40	174	---	---	---	---					
LOC102723828	102723828	broad.mit.edu	37	4	32007449	32007450	+	RNA	INS	-	-	C			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:32007449_32007450insC	ENST00000513211.1	+	0	426																											ttcctcttcttcttcctcttct	0.480													2	4	---	---	---	---					
UBA6-AS1	550112	broad.mit.edu	37	4	68896880	68896880	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:68896880delT	ENST00000500538.2	+	0	1905																											aattttccactacctacccaa	0.493													2	4	---	---	---	---					
IL21-AS1	100996941	broad.mit.edu	37	4	123556924	123556924	+	RNA	DEL	T	T	-	rs80270786		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr4:123556924delT	ENST00000417927.1	+	0	2797																											ACAGTACGTATTTTTTTTTTA	0.303													2	4	---	---	---	---					
RP11-804N13.1	0	broad.mit.edu	37	5	21625520	21625521	+	RNA	INS	-	-	T			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr5:21625520_21625521insT	ENST00000522350.1	+	0	476																											ggggttgtttatttcttgtaaa	0.371													2	4	---	---	---	---					
TCP11	6954	broad.mit.edu	37	6	35108525	35108525	+	Splice_Site	DEL	G	G	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr6:35108525delG	ENST00000311875.5	-	2	579	c.163_splice	c.e2+1	p.P54_splice	TCP11_ENST00000512012.1_Splice_Site_p.P41_splice|TCP11_ENST00000373979.2_Intron|TCP11_ENST00000244645.3_5'UTR|TCP11_ENST00000412155.2_Intron|TCP11_ENST00000444780.2_Splice_Site_p.P54_splice|TCP11_ENST00000373974.4_Intron|TCP11_ENST00000510465.1_5'UTR|TCP11_ENST00000418521.2_Intron			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	41					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						TGGACCTACAGGGAGGGGGGT	0.647													8	38	---	---	---	---					
RASA4CP	401331	broad.mit.edu	37	7	44073250	44073251	+	RNA	INS	-	-	AAC			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:44073250_44073251insAAC	ENST00000446874.1	-	0	502																											acttggtatcaaacaacaacaa	0.436													2	4	---	---	---	---					
STAG3L2	442582	broad.mit.edu	37	7	74300557	74300564	+	RNA	DEL	AGAGCTCC	AGAGCTCC	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr7:74300557_74300564delAGAGCTCC	ENST00000423186.1	-	0	573_580							P0CL84	ST3L2_HUMAN								nucleus	binding	p.E82fs*32(2)		breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						CGGCCAGTGAAGAGCTCCAGGCGTGCGG	0.572													5	2	---	---	---	---					
GS1-57L11.1	0	broad.mit.edu	37	8	2663275	2663275	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:2663275delA	ENST00000520024.1	+	0	300																											CATGTGGCTGAAAAAAGACTC	0.448													2	4	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117028113	117028113	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr8:117028113delT	ENST00000505156.2	-	0	1558					NR_046215.1																						acttaatagcttttttttttc	0.303													2	4	---	---	---	---					
LINC01410	103352539	broad.mit.edu	37	9	66461837	66461838	+	RNA	INS	-	-	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:66461837_66461838insA	ENST00000424345.1	+	0	224																											atacctcatttattgagaattt	0.322													4	3	---	---	---	---					
LINC01410	103352539	broad.mit.edu	37	9	66464331	66464332	+	RNA	INS	-	-	A	rs142894132		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:66464331_66464332insA	ENST00000424345.1	+	0	224																											GCACAATAGACAAAATATTCTC	0.332													4	4	---	---	---	---					
NR4A3	8013	broad.mit.edu	37	9	102590616	102590618	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr9:102590616_102590618delCAC	ENST00000330847.1	+	2	369_371	c.325_327delCAC	c.(325-327)del	p.H119del	NR4A3_ENST00000338488.4_In_Frame_Del_p.H108del|NR4A3_ENST00000395097.2_In_Frame_Del_p.H108del			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	108					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				ccatcaccatcaccaccaccacc	0.616			T	EWSR1	extraskeletal myxoid chondrosarcoma								7	86	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711207	6711209	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:6711207_6711209delCTT	ENST00000309577.6	-	4	518_520	c.355_357delAAG	c.(355-357)del	p.K119del	CHD4_ENST00000357008.2_In_Frame_Del_p.K119del|CHD4_ENST00000544040.1_In_Frame_Del_p.K112del|CHD4_ENST00000544484.1_In_Frame_Del_p.K116del			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	119	Poly-Lys.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding	p.K119delK(3)		central_nervous_system(2)	2						TAGGTCCAAGCTTCTTCTTCTTC	0.537													7	88	---	---	---	---					
RP11-54A9.1	0	broad.mit.edu	37	12	76672342	76672343	+	RNA	DEL	GT	GT	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr12:76672342_76672343delGT	ENST00000553247.1	+	0	77																											TGGCATGGTAGTGTGTGTGGCT	0.485													2	4	---	---	---	---					
KTN1-AS1	100129075	broad.mit.edu	37	14	56014174	56014174	+	RNA	DEL	G	G	-	rs72015246		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:56014174delG	ENST00000554558.1	-	0	364																											aaaaaaaaaagaaTTGGCACA	0.443													5	11	---	---	---	---					
RP11-486O13.4	0	broad.mit.edu	37	14	70987174	70987175	+	RNA	DEL	TG	TG	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr14:70987174_70987175delTG	ENST00000556646.1	-	0	183																											ctactctgcctgtgttctgtca	0.416													2	4	---	---	---	---					
LOC102723461	102723461	broad.mit.edu	37	15	21965351	21965351	+	RNA	DEL	A	A	-	rs138566364		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:21965351delA	ENST00000500487.1	-	0	254																											ttcacttactaaaaaaaaaat	0.363													2	4	---	---	---	---					
GOLGA6L2	283685	broad.mit.edu	37	15	23685749	23685751	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:23685749_23685751delCTC	ENST00000567107.1	-	8	1923_1925	c.1871_1873delGAG	c.(1870-1875)gaa>g	p.GE624del	GOLGA6L2_ENST00000312015.5_Intron|GOLGA6L2_ENST00000345070.5_Intron					golgin A6 family-like 2											breast(1)|endometrium(7)	8						ctcgcatcttctcctcctggtcc	0.586													3	6	---	---	---	---					
LOC101929232	101929232	broad.mit.edu	37	15	29040257	29040258	+	RNA	INS	-	-	TG	rs149728175	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr15:29040257_29040258insTG	ENST00000562423.1	+	0	267																											CAAAAGAAATAtgtgtgtgtgt	0.337													3	5	---	---	---	---					
RP11-10K17.6	0	broad.mit.edu	37	16	5192290	5192290	+	RNA	DEL	A	A	-	rs79587073		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:5192290delA	ENST00000589323.1	+	0	451																											tcccatttctaaaaaaaaaaa	0.483													2	4	---	---	---	---					
RP11-26L20.3	0	broad.mit.edu	37	16	55326242	55326242	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:55326242delT	ENST00000558730.2	-	0	88																											ggaagacagataatgaacaag	0.458													2	4	---	---	---	---					
NFAT5	10725	broad.mit.edu	37	16	69726420	69726422	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr16:69726420_69726422delCAG	ENST00000349945.1	+	14	3962_3964	c.2410_2412delCAG	c.(2410-2412)del	p.Q812del	NFAT5_ENST00000393742.2_In_Frame_Del_p.Q812del|NFAT5_ENST00000354436.2_In_Frame_Del_p.Q888del|NFAT5_ENST00000567239.1_In_Frame_Del_p.Q905del|NFAT5_ENST00000566899.1_In_Frame_Del_p.Q812del|NFAT5_ENST00000432919.1_In_Frame_Del_p.Q906del	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	888					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.Q804Q(1)|p.Q898Q(1)		NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						ATCTAATcaacagcagcagcagc	0.473													8	102	---	---	---	---					
RP11-260A9.6	0	broad.mit.edu	37	17	25318216	25318216	+	RNA	DEL	T	T	-	rs111803514		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr17:25318216delT	ENST00000580686.1	-	0	189																											TGCTGGCCTCTGGCAGGCTGG	0.612													2	4	---	---	---	---					
SPPL2B	56928	broad.mit.edu	37	19	2348975	2348976	+	RNA	DEL	TC	TC	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:2348975_2348976delTC	ENST00000452401.2	+	0	1431				AC005258.3_ENST00000590001.1_RNA			Q8TCT7	PSL1_HUMAN	signal peptide peptidase like 2B							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGATTCCGTTCTCTCTCCACA	0.520													4	2	---	---	---	---					
ZIM2-AS1	101929059	broad.mit.edu	37	19	57282349	57282349	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr19:57282349delT	ENST00000595954.1	+	0	71				AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000594400.1_RNA																							TTGGAAAAAATGCATAATAAT	0.224													2	4	---	---	---	---					
NKX2-4	644524	broad.mit.edu	37	20	21378018	21378020	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:21378018_21378020delTGC	ENST00000351817.4	-	1	646_648	c.18_20delGCA	c.(16-21)aac>aa	p.KH6del		NM_033176.1	NP_149416.1	Q9H2Z4	NKX24_HUMAN	NK2 homeobox 4	6					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(2)|upper_aerodigestive_tract(1)	3						GGGCGTCGTGTGCTTTGGGCTCA	0.739													12	26	---	---	---	---					
DLGAP4-AS1	101926987	broad.mit.edu	37	20	35185947	35185947	+	RNA	DEL	A	A	-	rs112371150		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr20:35185947delA	ENST00000439595.1	-	0	467				RP5-977B1.7_ENST00000425233.1_RNA|RP5-977B1.11_ENST00000561134.1_RNA																							actccgtctcaaaaaaaaaaa	0.552													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11087107	11087108	+	RNA	INS	-	-	A	rs59538900		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:11087107_11087108insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gactccatctcaaaaaaaaatt	0.460													5	1	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11090438	11090438	+	RNA	DEL	T	T	-	rs111496627		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	682f554f-98f2-451a-b28c-d9a10cc66211	g.chr21:11090438delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aattatttacttttttttttt	0.398													4	2	---	---	---	---					
CROCCP2	84809	broad.mit.edu	37	1	16960045	16960045	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:16960045delT	ENST00000412962.1	-	0	16																											atacaaaaaattagccaggtg	0.537													2	4	---	---	---	---					
LINC01355	100996511	broad.mit.edu	37	1	23611611	23611612	+	RNA	INS	-	-	TGAG	rs58087683	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:23611611_23611612insTGAG	ENST00000566551.1	-	0	1633_1634																											gcctggaggactgagactcagt	0.480													4	3	---	---	---	---					
LOC102606465	102606465	broad.mit.edu	37	1	101532419	101532419	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:101532419delA	ENST00000446527.1	+	0	143				RP11-421L21.3_ENST00000453011.1_RNA|RP11-421L21.3_ENST00000416329.1_RNA																							ttacataggtaaatatgtgct	0.403													2	4	---	---	---	---					
RP11-297H3.3	0	broad.mit.edu	37	1	170183980	170183981	+	RNA	DEL	CA	CA	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:170183980_170183981delCA	ENST00000439184.1	+	0	304																											gtctctctgtcacacacacaca	0.465													4	3	---	---	---	---					
RP1-35C21.2	0	broad.mit.edu	37	1	177504597	177504598	+	RNA	INS	-	-	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:177504597_177504598insA	ENST00000438575.1	-	0	296																											aaacaaaaaagaaaaaaaaaag	0.386													2	4	---	---	---	---					
RP11-323I1.1	0	broad.mit.edu	37	1	213954098	213954098	+	RNA	DEL	G	G	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:213954098delG	ENST00000456240.1	+	0	143																											agggctcagtggtgcatgcct	0.517													2	4	---	---	---	---					
LOC101927787	101927787	broad.mit.edu	37	1	234811423	234811424	+	RNA	INS	-	-	TG			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr1:234811423_234811424insTG	ENST00000442382.1	-	0	96																											gtgtgtgtgcatgtgtgtgtgt	0.450													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22174521	22174522	+	RNA	INS	-	-	AGAA	rs79348110	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:22174521_22174522insAGAA	ENST00000450551.1	-	0	296				AC068490.1_ENST00000430520.1_lincRNA																							gtgatgaagagagaaagaaagg	0.381													3	3	---	---	---	---					
LOC102723824	102723824	broad.mit.edu	37	2	42389868	42389869	+	RNA	DEL	CA	CA	-	rs140855840		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:42389868_42389869delCA	ENST00000422013.2	-	0	262																											aaaacaaaaccacacacacaca	0.515													2	4	---	---	---	---					
AC105399.2	0	broad.mit.edu	37	2	78019880	78019880	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:78019880delT	ENST00000422418.1	+	0	130																											TAAAAATTCCTTTTTTTTTTT	0.393													3	3	---	---	---	---					
LINC01114	284998	broad.mit.edu	37	2	105366609	105366609	+	RNA	DEL	G	G	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:105366609delG	ENST00000425879.1	-	0	1754					NR_038231.1																						TGAGGCCTGTGGAGGTTGAAG	0.642													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	164688145	164688145	+	RNA	DEL	A	A	-	rs35683701		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr2:164688145delA	ENST00000429636.1	-	0	379																											cttacctttcacaggttacaa	0.408													5	2	---	---	---	---					
SUCLG2-AS1	101927111	broad.mit.edu	37	3	67971538	67971538	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr3:67971538delA	ENST00000482677.1	+	0	1653																											TGCGTCACTGAAAAAAAATGA	0.413													2	4	---	---	---	---					
RP11-501O2.4	0	broad.mit.edu	37	3	147946505	147946508	+	RNA	DEL	AACT	AACT	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr3:147946505_147946508delAACT	ENST00000460324.1	-	0	317																											TGTCaaaaagaactaacatgtttt	0.304													2	4	---	---	---	---					
RP11-625I7.1	0	broad.mit.edu	37	4	78383580	78383581	+	RNA	INS	-	-	T	rs146128986	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr4:78383580_78383581insT	ENST00000513871.1	-	0	122																											gttttgttttgtttttttgctt	0.386													2	4	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190767809	190767809	+	RNA	DEL	C	C	-	rs66472777		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr4:190767809delC	ENST00000511785.1	-	0	425																											attctcCGTGCCGTGTCCCTC	0.632													2	4	---	---	---	---					
LOC285696	285696	broad.mit.edu	37	5	17189014	17189015	+	RNA	INS	-	-	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr5:17189014_17189015insA	ENST00000399760.2	-	0	971					NR_027253.1																						AGAAGACACAGAAAAAAAAAGC	0.322													2	4	---	---	---	---					
LINC01336	104326191	broad.mit.edu	37	5	74347312	74347312	+	RNA	DEL	T	T	-	rs34550195		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr5:74347312delT	ENST00000503568.1	-	0	215																											TATGTGGTGCTGTGATAAGCC	0.537													4	2	---	---	---	---					
RP11-203H2.1	0	broad.mit.edu	37	6	8331045	8331045	+	RNA	DEL	C	C	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr6:8331045delC	ENST00000439891.2	+	0	269																											TGGTTCTGCTCCACAGTGTGG	0.498													2	4	---	---	---	---					
LINC01010	154092	broad.mit.edu	37	6	134787874	134787874	+	RNA	DEL	G	G	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr6:134787874delG	ENST00000431422.1	+	0	275				RP11-557H15.3_ENST00000417483.1_lincRNA	NR_038217.1|NR_038218.1																						actagtccaagaaACCCAGAA	0.363													2	4	---	---	---	---					
RASA4CP	401331	broad.mit.edu	37	7	44073250	44073251	+	RNA	INS	-	-	AAC			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr7:44073250_44073251insAAC	ENST00000446874.1	-	0	502																											acttggtatcaaacaacaacaa	0.436													2	4	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	64778994	64778994	+	RNA	DEL	C	C	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr8:64778994delC	ENST00000524360.1	-	0	247				RP11-32K4.1_ENST00000523191.1_RNA|RP11-32K4.1_ENST00000521958.1_RNA																							ttagatagttcccagagtgcc	0.527													2	4	---	---	---	---					
AC104417.1	0	broad.mit.edu	37	8	143026959	143026960	+	RNA	DEL	GC	GC	-	rs57562651		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr8:143026959_143026960delGC	ENST00000408196.1	+	0	100_101																											gcatgtgtgtgcgtgtgcatgt	0.540													2	4	---	---	---	---					
LINC01410	103352539	broad.mit.edu	37	9	66461837	66461838	+	RNA	INS	-	-	A			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr9:66461837_66461838insA	ENST00000424345.1	+	0	224																											atacctcatttattgagaattt	0.322													4	3	---	---	---	---					
LOC403323	403323	broad.mit.edu	37	9	66522446	66522446	+	RNA	DEL	C	C	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr9:66522446delC	ENST00000445604.2	-	0	1465																											TGTCACATGTCCTGCTACCCC	0.483													2	4	---	---	---	---					
LINC01501	340515	broad.mit.edu	37	9	93249341	93249341	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr9:93249341delA	ENST00000449990.1	-	0	647					NR_034157.1																						ATCAGAGAGCAAAAAAAGTGA	0.493													2	4	---	---	---	---					
RP11-94P11.4	0	broad.mit.edu	37	11	105181392	105181392	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr11:105181392delA	ENST00000528811.1	-	0	96																											TTCAGTACCTATCTCCTTCAA	0.428													2	4	---	---	---	---					
RN7SL770P	0	broad.mit.edu	37	12	56589124	56589124	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr12:56589124delT	ENST00000581566.1	+	0	194																											agtgcagtggtgcgatcatgg	0.552													2	4	---	---	---	---					
RP11-171L9.1	0	broad.mit.edu	37	12	78928361	78928361	+	RNA	DEL	G	G	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr12:78928361delG	ENST00000546865.1	-	0	85																											tttgaaccttggtctttttca	0.393													2	4	---	---	---	---					
RP11-244H18.3	0	broad.mit.edu	37	14	20108142	20108142	+	RNA	DEL	C	C	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr14:20108142delC	ENST00000551144.1	+	0	438				RP11-597A11.1_ENST00000548261.1_RNA																							ATGATGCCCACGTGAGCTGGC	0.408													4	3	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20143915	20143915	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr14:20143915delA	ENST00000548261.1	+	0	391																											ACAAGCAACCAAAAACTACAC	0.428													3	5	---	---	---	---					
RP11-486O13.4	0	broad.mit.edu	37	14	70987174	70987175	+	RNA	DEL	TG	TG	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr14:70987174_70987175delTG	ENST00000556646.1	-	0	183																											ctactctgcctgtgttctgtca	0.416													2	4	---	---	---	---					
LOC102723461	102723461	broad.mit.edu	37	15	21965351	21965351	+	RNA	DEL	A	A	-	rs138566364		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr15:21965351delA	ENST00000500487.1	-	0	254																											ttcacttactaaaaaaaaaat	0.363													2	4	---	---	---	---					
RP11-507B12.1	0	broad.mit.edu	37	15	61978601	61978601	+	RNA	DEL	C	C	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr15:61978601delC	ENST00000559590.1	-	0	57																											tacctctgtaccaggacattt	0.463													2	4	---	---	---	---					
RP11-510J16.5	0	broad.mit.edu	37	16	82142059	82142059	+	RNA	DEL	C	C	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr16:82142059delC	ENST00000567021.1	-	0	43																											ttgataggttcagcaaaccac	0.428													2	4	---	---	---	---					
OR1R1P	9596	broad.mit.edu	37	17	3289283	3289284	+	RNA	INS	-	-	ACAG	rs141499169	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr17:3289283_3289284insACAG	ENST00000573491.1	-	0	169																											TGGTGGACGGAACAGACGCCCA	0.644													4	2	---	---	---	---					
MYHAS	100128560	broad.mit.edu	37	17	10480115	10480115	+	RNA	DEL	G	G	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr17:10480115delG	ENST00000587182.1	+	0	231																											TGTAGACTGTGGGAGAAGAGT	0.438													2	4	---	---	---	---					
RP11-861E21.1	0	broad.mit.edu	37	18	12433732	12433732	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr18:12433732delT	ENST00000589843.1	+	0	104																											ccggccagtattttttttttt	0.557													3	2	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22420746	22420749	+	RNA	DEL	TGTA	TGTA	-	rs150796141		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr18:22420746_22420749delTGTA	ENST00000582650.1	+	0	235																											tgtacgtatgtgtatgtgtctatg	0.402													4	2	---	---	---	---					
RP11-157P23.2	0	broad.mit.edu	37	18	45049153	45049154	+	RNA	INS	-	-	A	rs146814119	by1000genomes	TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr18:45049153_45049154insA	ENST00000565127.1	+	0	275																											atattttttttatcccctacaG	0.426													4	3	---	---	---	---					
AC008984.2	0	broad.mit.edu	37	19	54842290	54842290	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr19:54842290delT	ENST00000507363.1	-	0	430																											cagccCCCTCtttttttttta	0.557													2	4	---	---	---	---					
FAM182A	284800	broad.mit.edu	37	20	26054990	26054992	+	RNA	DEL	CAC	CAC	-	rs111574025		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr20:26054990_26054992delCAC	ENST00000376398.2	+	0	819					NR_026713.1															breast(1)|endometrium(2)|kidney(1)	4						acttcattatcaccacctCcacc	0.458													2	4	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29595617	29595618	+	RNA	INS	-	-	A	rs145720535		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr20:29595617_29595618insA	ENST00000432067.1	-	0	74																											CTATTCCATGTAAAAAAATCAC	0.401													2	4	---	---	---	---					
APCDD1L-AS1	149773	broad.mit.edu	37	20	57132361	57132361	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr20:57132361delA	ENST00000427140.1	+	0	943					NR_034147.1																						tgctgagtggagggagggtgt	0.547													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11045626	11045626	+	RNA	DEL	G	G	-	rs60108847		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr21:11045626delG	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCAAAATAAGATGTGAAAAG	0.363													6	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11069012	11069013	+	RNA	INS	-	-	C	rs150046862		TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr21:11069012_11069013insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tttttcaacttcaaaaaattaa	0.272													3	5	---	---	---	---					
ABCC13	150000	broad.mit.edu	37	21	15696997	15696998	+	RNA	INS	-	-	AA			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr21:15696997_15696998insAA	ENST00000482980.1	+	0	2888																											ctgtctcaaagaaaaaaaaaaa	0.446													2	4	---	---	---	---					
AP000318.2	0	broad.mit.edu	37	21	35657458	35657458	+	RNA	DEL	A	A	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr21:35657458delA	ENST00000427022.1	+	0	430																											tcctcgtgataagtgtattta	0.433													2	4	---	---	---	---					
CTA-833B7.2	0	broad.mit.edu	37	22	37248347	37248347	+	RNA	DEL	T	T	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chr22:37248347delT	ENST00000330602.2	-	0	349																											tagcggggcgtggtggcagat	0.502													2	4	---	---	---	---					
TSIX	9383	broad.mit.edu	37	X	73047124	73047125	+	RNA	DEL	AC	AC	-			TCGA-GN-A4U8-06A-11D-A32N-08	TCGA-GN-A4U8-11A-11D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ed20959-4227-4868-b41a-972b2074725c	862ef39a-d56e-43e6-91eb-be0aa35560d1	g.chrX:73047124_73047125delAC	ENST00000604411.1	+	0	35085_35086				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCCACACATGACACACACACAC	0.470													8	96	---	---	---	---