Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
APOBEC3B	9582	broad.mit.edu	37	22	39380206	39380206	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr22:39380206C>T	ENST00000402182.3	+	2	199	c.144C>T	c.(142-144)ctC>ctT	p.L48L	APOBEC3B_ENST00000407298.3_Silent_p.L48L|APOBEC3B_ENST00000333467.3_Silent_p.L48L			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	48					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					GCTCAAATCTCCTTTGGGACA	0.483000													18	35					0	0	0.654019	0	0
MALAT1	378938	broad.mit.edu	37	11	65268581	65268581	+	RNA	SNP	T	T	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:65268581T>C	ENST00000534336.1	+	0	3349					NR_002819.2																						TTAGTTGGGGTAATGAAGTAT	0.343000													21	40					0	0	0.608945	0	0
TTN	7273	broad.mit.edu	37	2	179614557	179614557	+	Silent	SNP	T	T	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:179614557T>G	ENST00000360870.5	-	46	12792	c.12570A>C	c.(12568-12570)gtA>gtC	p.V4190V	TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3534							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAACCATGTTACAACTGGCT	0.373000													18	32					0	0	0.575678	0	0
CXorf67	340602	broad.mit.edu	37	X	51151079	51151079	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chrX:51151079T>A	ENST00000342995.2	+	1	1313	c.1211T>A	c.(1210-1212)gTc>gAc	p.V404D						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						TGGCATGCAGTCCGTATGCGT	0.597000													20	9					0	0	0.592651	0	0
MYO9A	4649	broad.mit.edu	37	15	72191306	72191306	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:72191306C>T	ENST00000356056.5	-	25	4010	c.3538G>A	c.(3538-3540)Gga>Aga	p.G1180R	MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000424560.1_Missense_Mutation_p.G1180R|MYO9A_ENST00000444904.1_Missense_Mutation_p.G1161R|MYO9A_ENST00000566885.1_Missense_Mutation_p.G800R|MYO9A_ENST00000564571.1_Missense_Mutation_p.G1180R	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1180	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GATCCATATCCCTTAATATTC	0.343000													75	108					0	0	0.870114	0	0
CLN6	54982	broad.mit.edu	37	15	68500616	68500616	+	Silent	SNP	G	G	A	rs140319056	byFrequency	TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:68500616G>A	ENST00000249806.5	-	7	955	c.798C>T	c.(796-798)ttC>ttT	p.F266F	CLN6_ENST00000418702.2_Silent_p.F137F|RP11-315D16.2_ENST00000562767.1_Intron|CLN6_ENST00000566347.1_Silent_p.F203F|CLN6_ENST00000565471.1_Silent_p.F113F|CLN6_ENST00000538696.1_Silent_p.F298F	NM_017882.2	NP_060352.1	Q9NWW5	CLN6_HUMAN	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	266					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity			large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GGGTCAGTGCGAAGGAGGAGA	0.592000													26	87					0	0	0.717897	0	0
PKD1L2	114780	broad.mit.edu	37	16	81253771	81253771	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:81253771C>T	ENST00000599697.1	-	1	204	c.205G>A	c.(205-207)Gaa>Aaa	p.E69K	PKD1L2_ENST00000337114.4_RNA|PKD1L2_ENST00000525539.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	69	C-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding	p.E69K(2)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						TGGGTGCCTTCGTCCTGAATG	0.562000													33	53					0	0	0.740014	0	0
LOC442028	442028	broad.mit.edu	37	2	95552661	95552661	+	RNA	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:95552661G>A	ENST00000568768.1	-	0	476																											TTAAACGAAGGTCTGACTCCT	0.368000													10	19					0	0	0.361761	0	0
MTG2	26164	broad.mit.edu	37	20	60770987	60770987	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:60770987G>A	ENST00000370823.3	+	3	352	c.334G>A	c.(334-336)Gga>Aga	p.G112R	MTG2_ENST00000436421.2_Missense_Mutation_p.G112R|MTG2_ENST00000536470.1_5'UTR	NM_015666.3	NP_056481.1			mitochondrial ribosome-associated GTPase 2																		AGGCAACGGTGGACACGTCAT	0.607000													22	58					0	0	0.667858	0	0
CHMP5	51510	broad.mit.edu	37	9	33280807	33280807	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:33280807G>A	ENST00000419016.2	+	7	537	c.496_splice	c.e7-1	p.G166_splice	CHMP5_ENST00000487080.1_3'UTR|CHMP5_ENST00000223500.8_Splice_Site_p.D204_splice	NM_001195536.1	NP_001182465.1	Q9NZZ3	CHMP5_HUMAN	charged multivesicular body protein 5	0					cellular membrane organization|protein transport	cytosol|endosome membrane	protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10			LUSC - Lung squamous cell carcinoma(29;0.00506)			CTTTTTACAGGATGGAGTTCT	0.313000													14	101					0	0	0.520397	0	0
IL10RB	3588	broad.mit.edu	37	21	34668534	34668534	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr21:34668534C>T	ENST00000290200.2	+	7	958	c.850C>T	c.(850-852)Cca>Tca	p.P284S		NM_000628.4	NP_000619.3			interleukin 10 receptor, beta											endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14						TTTCTCCTTTCCATTGTCGGA	0.448000													51	67					0	0	0.870114	0	0
OR2T3	343173	broad.mit.edu	37	1	248637245	248637245	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:248637245C>T	ENST00000359594.2	+	1	619	c.594C>T	c.(592-594)tcC>tcT	p.S198S		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGACGTCTCCCTCTATAAGA	0.522000													33	48					0	0	0.796494	0	0
COL6A6	131873	broad.mit.edu	37	3	130286982	130286982	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:130286982G>A	ENST00000358511.6	+	5	1966	c.1935G>A	c.(1933-1935)atG>atA	p.M645I	COL6A6_ENST00000453409.2_Missense_Mutation_p.M645I	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	645	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AAACATTTATGAAAAACCTGG	0.423000													41	75					0	0	0.853193	0	0
RSAD1	55316	broad.mit.edu	37	17	48559550	48559550	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:48559550C>T	ENST00000258955.2	+	4	658	c.573C>T	c.(571-573)cgC>cgT	p.R191R		NM_018346.1	NP_060816.1	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing 1	191					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			TTCCCGGGCGCGTGTCTGTAG	0.667000											OREG0024567	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	52					0	0	0.387290	0	0
SMPD4P1	645280	broad.mit.edu	37	22	20970673	20970673	+	RNA	SNP	C	C	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr22:20970673C>G	ENST00000443839.1	-	0	1951																											AGAGAAGTGTCGCTTCAGGGG	0.587000													5	13					0	0	0.217242	0	0
CYP2C9	1559	broad.mit.edu	37	10	96741004	96741004	+	Silent	SNP	G	G	A	rs56718285		TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr10:96741004G>A	ENST00000260682.6	+	7	1038	c.1026G>A	c.(1024-1026)agG>agA	p.R342R		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	342					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TGCAAGACAGGAGCCACATGC	0.502000													41	79					0	0	0.864702	0	0
SALL3	27164	broad.mit.edu	37	18	76752243	76752243	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr18:76752243G>A	ENST00000575389.2	+	2	252	c.252G>A	c.(250-252)gaG>gaA	p.E84E	SALL3_ENST00000537592.2_Silent_p.E84E|SALL3_ENST00000536229.3_5'UTR			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TCGTGCACGAGGACGCGCCCG	0.726000													6	15					0	0	0.278610	0	0
ESPNP	284729	broad.mit.edu	37	1	17046596	17046596	+	RNA	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:17046596G>A	ENST00000492551.1	-	0	56					NR_026567.1																						TCACCACCTTGGGGTGGCCAA	0.597000													8	165					0	0	0.307466	0	0
THSD7B	80731	broad.mit.edu	37	2	137928321	137928321	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:137928321G>A	ENST00000409968.1	+	7	1714	c.1536G>A	c.(1534-1536)acG>acA	p.T512T	THSD7B_ENST00000272643.3_Silent_p.T512T|THSD7B_ENST00000485379.1_3'UTR|THSD7B_ENST00000413152.2_Silent_p.T481T|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GATTTAGAACGAGGCAGCGCC	0.458000													20	35					0	0	0.654019	0	0
RNF150	57484	broad.mit.edu	37	4	142053624	142053624	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:142053624G>A	ENST00000306799.3	-	1	992	c.339C>T	c.(337-339)cgC>cgT	p.R113R	RNF150_ENST00000420921.2_Intron|RNF150_ENST00000515673.1_Silent_p.R113R|RNF150_ENST00000507500.1_Silent_p.R113R	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150	113	PA.					integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					AGTTCTTGCCGCGGGTCGGGG	0.657000													6	14					0	0	0.248553	0	0
ADRB2	154	broad.mit.edu	37	5	148207303	148207303	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:148207303C>T	ENST00000305988.4	+	1	1148	c.909C>T	c.(907-909)atC>atT	p.I303I		NM_000024.5	NP_000015.1	P07550	ADRB2_HUMAN	adrenoceptor beta 2, surface	303					activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(3)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	ATAACCTCATCCGTAAGGAAG	0.473000													16	42					0	0	0.500413	0	0
HGF	3082	broad.mit.edu	37	7	81381481	81381481	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr7:81381481G>A	ENST00000222390.5	-	5	806	c.580C>T	c.(580-582)Cca>Tca	p.P194S	HGF_ENST00000457544.2_Missense_Mutation_p.P189S|HGF_ENST00000453411.1_Missense_Mutation_p.P189S|HGF_ENST00000444829.2_Missense_Mutation_p.P194S|HGF_ENST00000423064.2_Missense_Mutation_p.P194S	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	194	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CGTACCTCTGGATTGCTTGTG	0.478000													15	29					0	0	0.479597	0	0
VPS54	51542	broad.mit.edu	37	2	64208967	64208967	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:64208967C>T	ENST00000272322.4	-	3	345	c.191G>A	c.(190-192)tGg>tAg	p.W64*	VPS54_ENST00000409558.3_Nonsense_Mutation_p.W52*	NM_016516.2	NP_057600.2	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	64					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						ATATACAGTCCATCTATGTTG	0.363000													16	63					0	0	0.500413	0	0
PCDHA6	56142	broad.mit.edu	37	5	140207820	140207820	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:140207820C>T	ENST00000529310.1	+	1	258	c.144C>T	c.(142-144)atC>atT	p.I48I	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Silent_p.I48I|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCCGGATCGCGCAGGACC	0.657000													23	60					0	0	0.654019	0	0
SCN10A	6336	broad.mit.edu	37	3	38783935	38783935	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:38783935C>T	ENST00000449082.2	-	13	1952	c.1953G>A	c.(1951-1953)tgG>tgA	p.W651*		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	651					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGAGCTTCACCCACATGGGGC	0.512000													39	76					0	0	0.827153	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61299158	61299158	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:61299158C>T	ENST00000217159.1	+	8	1739	c.1534C>T	c.(1534-1536)Cca>Tca	p.P512S	SLCO4A1_ENST00000370507.1_Missense_Mutation_p.P512S|SLCO4A1_ENST00000470412.1_3'UTR	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	512	Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CAGCTGCCAGCCAGAACACTA	0.652000													26	120					0	0	0.706142	0	0
DDX60	55601	broad.mit.edu	37	4	169197182	169197182	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:169197182G>A	ENST00000393743.3	-	15	2420	c.2129C>T	c.(2128-2130)tCt>tTt	p.S710F		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	710							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TGGATGTAAAGAACTTGCCAA	0.358000													20	35					0	0	0.639603	0	0
MKLN1	4289	broad.mit.edu	37	7	131012748	131012748	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr7:131012748C>T	ENST00000352689.6	+	1	130	c.90C>T	c.(88-90)taC>taT	p.Y30Y	MKLN1_ENST00000429546.1_Intron|MKLN1_ENST00000421797.2_Intron	NM_013255.4	NP_037387.2	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing kelch motifs	30					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28	Melanoma(18;0.162)					CCTCCACCTACCTTCCCGAGT	0.672000													4	21					0	0	0.150653	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616573	77616573	+	Missense_Mutation	SNP	G	G	A	rs144986646	by1000genomes	TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr8:77616573G>A	ENST00000521891.2	+	2	698	c.250G>A	c.(250-252)Gaa>Aaa	p.E84K	ZFHX4_ENST00000518282.1_Missense_Mutation_p.E84K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E84K|ZFHX4_ENST00000050961.6_Missense_Mutation_p.E84K|ZFHX4_ENST00000517683.1_Intron	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	84						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCCTGCAACGAATGTGCCAC	0.507000										HNSCC(33;0.089)			85	104					0	0	0.870114	0	0
COL4A4	1286	broad.mit.edu	37	2	227958912	227958912	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:227958912C>T	ENST00000396625.3	-	20	1505	c.1298G>A	c.(1297-1299)gGa>gAa	p.G433E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G433E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	433	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCCTGGTTTTCCTGGAGCAGA	0.552000													23	47					0	0	0.608945	0	0
C12orf74	338809	broad.mit.edu	37	12	93100879	93100879	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:93100879C>T	ENST00000544406.2	+	2	738	c.472C>T	c.(472-474)Ctg>Ttg	p.L158L	C12orf74_ENST00000397833.3_Silent_p.L158L			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	158										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						AGGCCACTTCCTGCCCAGCCC	0.562000													4	28					0	0	0.150653	0	0
INPP5B	3633	broad.mit.edu	37	1	38331529	38331529	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:38331529C>T	ENST00000373023.2	-	22	2751	c.2658G>A	c.(2656-2658)ctG>ctA	p.L886L	INPP5B_ENST00000373027.1_Silent_p.L642L|INPP5B_ENST00000373024.3_Silent_p.L806L|INPP5B_ENST00000373026.1_Silent_p.L886L	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	886	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GGAAAAGCAGCAGGGCTTCGG	0.512000													18	26					0	0	0.539581	0	0
TUBA3D	113457	broad.mit.edu	37	2	132235770	132235770	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:132235770G>A	ENST00000321253.6	+	2	144	c.37G>A	c.(37-39)Ggt>Agt	p.G13S		NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	13					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		GGGGCAGGCGGGTGTCCAGAT	0.498000													29	60					0	0	0.796494	0	0
NPC1L1	29881	broad.mit.edu	37	7	44578514	44578514	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr7:44578514G>A	ENST00000289547.4	-	2	1537	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	NPC1L1_ENST00000546276.1_Silent_p.F494F|NPC1L1_ENST00000423141.1_Silent_p.F494F|NPC1L1_ENST00000381160.3_Silent_p.F494F	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	494					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GGTTGTTCTGGAAATACTGCA	0.557000													15	45					0	0	0.457914	0	0
OR1N2	138882	broad.mit.edu	37	9	125315479	125315479	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:125315479G>A	ENST00000373688.2	+	1	89	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						CAGATCACACGAACTACAAGG	0.453000													25	32					0	0	0.667858	0	0
OBSCN	84033	broad.mit.edu	37	1	228459864	228459864	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:228459864C>T	ENST00000570156.2	+	20	6002	c.5928C>T	c.(5926-5928)gcC>gcT	p.A1976A	OBSCN_ENST00000359599.6_Silent_p.A448A|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000366709.4_Intron|RP5-1139B12.2_ENST00000602517.1_RNA|OBSCN_ENST00000422127.1_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	957	Ig-like 19.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGCGGACGCCGGGGAGTACA	0.642000													33	28					0	0	0.788014	0	0
SORBS1	10580	broad.mit.edu	37	10	97101161	97101161	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr10:97101161G>A	ENST00000371247.2	-	28	2740	c.2551C>T	c.(2551-2553)Cct>Tct	p.P851S	SORBS1_ENST00000361941.3_Missense_Mutation_p.P851S|SORBS1_ENST00000354106.3_Missense_Mutation_p.P821S|SORBS1_ENST00000607232.1_Missense_Mutation_p.P1111S|SORBS1_ENST00000371239.1_Missense_Mutation_p.P628S|SORBS1_ENST00000371227.4_Missense_Mutation_p.P805S|SORBS1_ENST00000347291.4_Missense_Mutation_p.P663S|SORBS1_ENST00000371246.2_Missense_Mutation_p.P873S|SORBS1_ENST00000353505.5_Missense_Mutation_p.P702S|SORBS1_ENST00000306402.6_Missense_Mutation_p.P598S|SORBS1_ENST00000393949.1_Missense_Mutation_p.P821S|SORBS1_ENST00000371249.2_Missense_Mutation_p.P633S|SORBS1_ENST00000371241.1_Missense_Mutation_p.P501S|SORBS1_ENST00000371245.3_Missense_Mutation_p.P702S|SORBS1_ENST00000277982.5_Missense_Mutation_p.P873S			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	851	SH3 1.				focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		TCagcaggaggaagaagctga	0.408000													16	55					0	0	0.520397	0	0
ZNF536	9745	broad.mit.edu	37	19	31040136	31040136	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:31040136G>A	ENST00000355537.3	+	4	3757	c.3610G>A	c.(3610-3612)Gat>Aat	p.D1204N		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1204					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CAGCAGCAGCGATGGCGGGGA	0.602000													14	53					0	0	0.457914	0	0
ZNF407	55628	broad.mit.edu	37	18	72345996	72345996	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr18:72345996C>T	ENST00000299687.5	+	1	3021	c.3021C>T	c.(3019-3021)tcC>tcT	p.S1007S	ZNF407_ENST00000577538.1_Silent_p.S1007S|ZNF407_ENST00000582337.1_Silent_p.S1007S|ZNF407_ENST00000309902.6_Silent_p.S1007S	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1007					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ATGTGTACTCCCAGAGAGATG	0.453000													29	79					0	0	0.750413	0	0
LIPC	3990	broad.mit.edu	37	15	58840749	58840749	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:58840749G>A	ENST00000414170.3	+	7	1316	c.1029G>A	c.(1027-1029)acG>acA	p.T343T	LIPC_ENST00000433326.2_Silent_p.T282T|LIPC_ENST00000299022.5_Silent_p.T343T|LIPC_ENST00000356113.6_Silent_p.T343T			P11150	LIPC_HUMAN	lipase, hepatic	343					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TCCTCGTAACGCGAGCCCAGT	0.632000													3	6					0	0	0.115264	0	0
CFH	3075	broad.mit.edu	37	1	196683021	196683021	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:196683021G>A	ENST00000367429.4	+	10	1733	c.1493G>A	c.(1492-1494)gGa>gAa	p.G498E		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	498	Sushi 8.				complement activation, alternative pathway	extracellular space		p.G498E(2)		NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GGGAAAGATGGATGGTCAGCT	0.333000													55	28					0	0	0.870114	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638622	234638622	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:234638622A>G	ENST00000482026.1	+	1	869	c.850A>G	c.(850-852)Agg>Ggg	p.R284G	UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000480628.1_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTGTGCCAACAGGAAGCCACT	0.438000													6	103					0	0	0.278610	0	0
CCK	885	broad.mit.edu	37	3	42299634	42299634	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:42299634C>T	ENST00000396169.2	-	5	1209	c.304G>A	c.(304-306)Gat>Aat	p.D102N	CCK_ENST00000334681.5_Missense_Mutation_p.D102N|CCK_ENST00000434608.1_Missense_Mutation_p.D102N	NM_000729.4	NP_000720.1	P06307	CCKN_HUMAN	cholecystokinin	102					axonogenesis|eating behavior|neuron migration		neuropeptide hormone activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6		Ovarian(412;0.0728)		KIRC - Kidney renal clear cell carcinoma(284;0.219)		CGGCCAAAATCCATCCAGCCC	0.587000													27	64					0	0	0.729181	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													4	28					0	0	0.184627	0	0
HMGXB4	10042	broad.mit.edu	37	22	35689093	35689093	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr22:35689093C>T	ENST00000216106.5	+	10	1875	c.1747C>T	c.(1747-1749)Ccc>Tcc	p.P583S	HMGXB4_ENST00000444518.2_Missense_Mutation_p.P474S	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	583					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GAATGGCTGTCCCAAACAGGT	0.498000													48	80					0	0	0.870114	0	0
THSD1	55901	broad.mit.edu	37	13	52971458	52971458	+	Missense_Mutation	SNP	C	C	T	rs141269153		TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr13:52971458C>T	ENST00000349258.4	-	3	1474	c.930G>A	c.(928-930)atG>atA	p.M310I	THSD1_ENST00000258613.4_Missense_Mutation_p.M310I|THSD1_ENST00000544466.1_Intron	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	310						extracellular region|integral to membrane|intracellular membrane-bounded organelle		p.M310I(1)		breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		TATTCTTCCCCATGTCAAACA	0.448000													26	40					0	0	0.667858	0	0
BCKDK	10295	broad.mit.edu	37	16	31120614	31120614	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:31120614G>A	ENST00000394951.1	+	3	693	c.70G>A	c.(70-72)Gca>Aca	p.A24T	AC135050.1_ENST00000517000.2_RNA|BCKDK_ENST00000287507.3_Missense_Mutation_p.A24T|BCKDK_ENST00000219794.6_Missense_Mutation_p.A24T|BCKDK_ENST00000394950.3_Missense_Mutation_p.A24T			O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	24					branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			breast(1)|stomach(1)	2						CCTGGGACCCGCACTCGCGCT	0.692000													3	21					0	0	0.115264	0	0
HELZ2	85441	broad.mit.edu	37	20	62198413	62198413	+	Silent	SNP	G	G	A	rs147456257	byFrequency	TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:62198413G>A	ENST00000467148.1	-	6	2367	c.2298C>T	c.(2296-2298)caC>caT	p.H766H	HELZ2_ENST00000427522.2_Silent_p.H197H	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		TGCCCCTGGCGTGGATGGGGT	0.662000													35	211					0	0	0.788014	0	0
USH1G	124590	broad.mit.edu	37	17	72916153	72916153	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:72916153T>C	ENST00000319642.1	-	2	960	c.778A>G	c.(778-780)Acc>Gcc	p.T260A		NM_173477.2	NP_775748.2	Q495M9	USH1G_HUMAN	Usher syndrome 1G (autosomal recessive)	260					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton			HN1/USH1G(2)	endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(3)	14	all_lung(278;0.172)|Lung NSC(278;0.207)					TTGGCGTAGGTGCCCTGGCGC	0.701000													51	51					0	0	0.870114	0	0
OR6K3	391114	broad.mit.edu	37	1	158687447	158687447	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:158687447G>A	ENST00000368146.1	-	1	506	c.507C>T	c.(505-507)ttC>ttT	p.F169F	OR6K3_ENST00000368145.1_Silent_p.F153F			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					GCAGGATAAGGAAACCGAAGA	0.512000													92	43					0	0	0.870114	0	0
ZNF18	7566	broad.mit.edu	37	17	11895895	11895895	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:11895895G>A	ENST00000322748.3	-	4	856	c.252C>T	c.(250-252)ctC>ctT	p.L84L	ZNF18_ENST00000454073.3_Silent_p.L84L|ZNF18_ENST00000580306.1_Silent_p.L84L|ZNF18_ENST00000580613.1_Silent_p.L33L	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	84	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		GCTCCAACATGAGGATCTCTA	0.527000													12	64					0	0	0.387290	0	0
SLC24A4	123041	broad.mit.edu	37	14	92922945	92922945	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr14:92922945C>T	ENST00000532405.1	+	12	1474	c.1248C>T	c.(1246-1248)tcC>tcT	p.S416S	SLC24A4_ENST00000531433.1_Silent_p.S397S|SLC24A4_ENST00000298877.1_Silent_p.S399S|SLC24A4_ENST00000351924.5_Silent_p.S380S|SLC24A4_ENST00000556739.1_3'UTR|SLC24A4_ENST00000393265.2_Silent_p.S352S			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	416						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCCCCTTCTCCGTGCCGGGTG	0.622000											OREG0022876	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	10					0	0	0.307466	0	0
DCDC1	341019	broad.mit.edu	37	11	31113050	31113050	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:31113050C>T	ENST00000597505.1	-	15	2126	c.2127G>A	c.(2125-2127)atG>atA	p.M709I	DCDC1_ENST00000437348.1_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GGCTCAGGATCATTCCAGTCT	0.418000													3	14					0	0	0.115264	0	0
COL21A1	81578	broad.mit.edu	37	6	56044586	56044586	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr6:56044586C>T	ENST00000244728.5	-	3	827	c.430G>A	c.(430-432)Gat>Aat	p.D144N	COL21A1_ENST00000535941.1_Missense_Mutation_p.D144N|COL21A1_ENST00000370819.1_Missense_Mutation_p.D144N	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	144	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GATTTGCCATCCGTAAGTACC	0.443000													16	15					0	0	0.500413	0	0
PCLO	27445	broad.mit.edu	37	7	82584204	82584204	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr7:82584204G>A	ENST00000423517.2	-	5	6402	c.6065C>T	c.(6064-6066)tCt>tTt	p.S2022F	PCLO_ENST00000333891.8_Missense_Mutation_p.S2022F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1953					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGGCACAACAGAATGTAAGCT	0.373000													31	54					0	0	0.729181	0	0
RTEL1	51750	broad.mit.edu	37	20	62298843	62298843	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:62298843C>T	ENST00000318100.4	+	8	1463	c.636C>T	c.(634-636)tcC>tcT	p.S212S	RTEL1_ENST00000360203.5_Silent_p.S212S|RTEL1_ENST00000370018.3_Silent_p.S212S|RTEL1-TNFRSF6B_ENST00000482936.1_Silent_p.S212S|RTEL1_ENST00000508582.2_Silent_p.S236S			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	212	Helicase ATP-binding.				DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			ACTACCTGTCCCGGAACCTGA	0.577000													60	456					0	0	0.870114	0	0
TAT	6898	broad.mit.edu	37	16	71604622	71604622	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:71604622C>T	ENST00000355962.4	-	8	1005	c.872G>A	c.(871-873)tGg>tAg	p.W291*	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	291					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	AATGAGGATCCAGCCCAACCT	0.488000													6	35					0	0	0.248553	0	0
TP53BP1	7158	broad.mit.edu	37	15	43712773	43712773	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:43712773G>A	ENST00000263801.3	-	21	4648	c.4396C>T	c.(4396-4398)Cct>Tct	p.P1466S	TP53BP1_ENST00000450115.2_Missense_Mutation_p.P1471S|TP53BP1_ENST00000382039.3_Missense_Mutation_p.P1421S|TP53BP1_ENST00000382044.4_Missense_Mutation_p.P1471S	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	1466					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GCCTGGAAAGGAATTTCTGGA	0.542000								Other conserved DNA damage response genes					19	68					0	0	0.557998	0	0
USHBP1	83878	broad.mit.edu	37	19	17370779	17370779	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:17370779G>A	ENST00000252597.3	-	5	868	c.695C>T	c.(694-696)tCc>tTc	p.S232F	USHBP1_ENST00000431146.2_Missense_Mutation_p.S168F	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	232							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						TTGGTTGTGGGAAAGATGTGG	0.582000													24	33					0	0	0.639603	0	0
NUMA1	4926	broad.mit.edu	37	11	71720190	71720190	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:71720190C>T	ENST00000393695.3	-	19	5212	c.4881G>A	c.(4879-4881)caG>caA	p.Q1627Q	NUMA1_ENST00000351960.6_Silent_p.Q491Q|NUMA1_ENST00000358965.6_Silent_p.Q1613Q	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1627					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						GCTCTTGGTTCTGCTGCTTCT	0.572000			T	RARA	APL								9	69					0	0	0.361761	0	0
TEK	7010	broad.mit.edu	37	9	27169586	27169586	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:27169586G>A	ENST00000380036.4	+	4	1029	c.587G>A	c.(586-588)gGa>gAa	p.G196E	TEK_ENST00000519097.1_Missense_Mutation_p.G92E|TEK_ENST00000406359.4_Missense_Mutation_p.G196E	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	196					angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TATATAGGAGGAAACCTCTTC	0.502000													42	81					0	0	0.870114	0	0
DLC1	10395	broad.mit.edu	37	8	12958068	12958068	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr8:12958068G>A	ENST00000276297.4	-	9	2187	c.1778C>T	c.(1777-1779)tCc>tTc	p.S593F	DLC1_ENST00000520226.1_Missense_Mutation_p.S82F|DLC1_ENST00000358919.2_Missense_Mutation_p.S156F|DLC1_ENST00000512044.2_Missense_Mutation_p.S190F	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	593					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGCGGACGGAAGACACCTC	0.697000													25	32					0	0	0.706142	0	0
SPERT	220082	broad.mit.edu	37	13	46287777	46287777	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr13:46287777C>T	ENST00000378966.3	+	2	925	c.509C>T	c.(508-510)tCg>tTg	p.S170L	SPERT_ENST00000310521.1_Missense_Mutation_p.S206L			Q8NA61	SPERT_HUMAN	spermatid associated	206						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CACAAGGCCTCGCTGGGCCGA	0.642000													26	38					0	0	0.667858	0	0
GYLTL1B	120071	broad.mit.edu	37	11	45949732	45949732	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:45949732C>T	ENST00000531526.1	+	13	1870	c.1759C>T	c.(1759-1761)Cac>Tac	p.H587Y	GYLTL1B_ENST00000401752.1_Missense_Mutation_p.H587Y|GYLTL1B_ENST00000325468.5_Missense_Mutation_p.H587Y|GYLTL1B_ENST00000529052.1_Missense_Mutation_p.H556Y|GYLTL1B_ENST00000536139.1_Missense_Mutation_p.H556Y	NM_152312.3	NP_689525.3	Q8N3Y3	LARG2_HUMAN	glycosyltransferase-like 1B	587					muscle cell homeostasis	Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(35;0.226)		GCACAGGTACCACGAGTGGCC	0.657000													24	26					0	0	0.667858	0	0
CTNNA2	1496	broad.mit.edu	37	2	80835375	80835375	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:80835375C>A	ENST00000466387.1	+	21	3086	c.2362C>A	c.(2362-2364)Cag>Aag	p.Q788K	CTNNA2_ENST00000343114.3_Missense_Mutation_p.Q467K|AC008067.2_ENST00000430876.1_RNA|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000496558.1_Missense_Mutation_p.Q788K|CTNNA2_ENST00000541047.1_Missense_Mutation_p.Q788K|CTNNA2_ENST00000402739.4_Missense_Mutation_p.Q788K|CTNNA2_ENST00000361291.4_Missense_Mutation_p.Q822K			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	788					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GTATTGCCATCAGCTTAATAT	0.418000													12	59					5.50884e-06	5.6331e-06	0.411799	1	0
AGK	55750	broad.mit.edu	37	7	141341105	141341105	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr7:141341105C>A	ENST00000355413.4	+	12	1044	c.784C>A	c.(784-786)Ccc>Acc	p.P262T	AGK_ENST00000535825.1_Intron|AGK_ENST00000473247.1_Missense_Mutation_p.P234T	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase	262					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					AGAGAGACCTCCCAATGAACC	0.468000													10	35					2.17888e-05	2.21968e-05	0.335167	1	0
SSH1	54434	broad.mit.edu	37	12	109186137	109186137	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:109186137G>A	ENST00000326495.5	-	14	1911	c.1818C>T	c.(1816-1818)acC>acT	p.T606T	SSH1_ENST00000326470.5_Silent_p.T617T|SSH1_ENST00000551165.1_Silent_p.T606T|SSH1_ENST00000360239.3_Silent_p.T294T	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	606					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GATCGAGCTGGGTTGGAAGCT	0.612000													19	38					0	0	0.557998	0	0
UIMC1	51720	broad.mit.edu	37	5	176396235	176396235	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:176396235T>A	ENST00000377219.2	-	6	687	c.521A>T	c.(520-522)aAc>aTc	p.N174I	UIMC1_ENST00000506128.1_Missense_Mutation_p.N174I|UIMC1_ENST00000377227.4_Missense_Mutation_p.N174I|UIMC1_ENST00000511320.1_Missense_Mutation_p.N174I	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	174	Necessary for interaction with NR6A1 N- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCAGCCTCGTTTCCCTGACT	0.498000													10	60					0	0	0.335167	0	0
ZFHX3	463	broad.mit.edu	37	16	72830830	72830830	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:72830830C>T	ENST00000268489.5	-	9	6423	c.5751G>A	c.(5749-5751)gaG>gaA	p.E1917E	ZFHX3_ENST00000397992.5_Silent_p.E1003E	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1917					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ACTCTTTCTTCTCTTTGGCCT	0.577000													27	29					0	0	0.681144	0	0
APOB	338	broad.mit.edu	37	2	21225534	21225534	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:21225534G>A	ENST00000233242.1	-	29	12887	c.12760C>T	c.(12760-12762)Cct>Tct	p.P4254S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4254					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACTCGAAAGGAAGTGTAATC	0.373000													200	361					0	0	0.870114	0	0
MUM1L1	139221	broad.mit.edu	37	X	105449720	105449720	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chrX:105449720G>A	ENST00000337685.2	+	5	1080	c.295G>A	c.(295-297)Gag>Aag	p.E99K	MUM1L1_ENST00000372552.1_Missense_Mutation_p.E99K|MUM1L1_ENST00000357175.2_Missense_Mutation_p.E99K	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	99										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						TATTCTGAATGAGAGAACAAA	0.443000													18	7					0	0	0.592651	0	0
OR5I1	10798	broad.mit.edu	37	11	55703636	55703636	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:55703636G>A	ENST00000301532.3	-	1	240	c.241C>T	c.(241-243)Ccc>Tcc	p.P81S		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						AGCATTTTGGGAACAATGTCT	0.388000													11	7					0	0	0.361761	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			55	73					0	0	0.870114	0	0
MIR518C	574477	broad.mit.edu	37	19	54212013	54212013	+	RNA	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:54212013C>T	ENST00000384822.1	+	0	25					NR_030199.1																						TGCTGTGACTCTCTGGAGGGA	0.398000													11	17					0	0	0.387290	0	0
SLC45A3	85414	broad.mit.edu	37	1	205632162	205632162	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:205632162G>A	ENST00000367145.3	-	3	1052	c.757C>T	c.(757-759)Ctg>Ttg	p.L253L		NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	253					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			AGGGCGCCCAGGTTCCGGAAA	0.711000			T	"""ETV1, ETV5, ELK4, ERG"""	prostate								16	63					0	0	0.500413	0	0
SCEL	8796	broad.mit.edu	37	13	78184235	78184235	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr13:78184235A>G	ENST00000535157.1	+	20	1375	c.1205A>G	c.(1204-1206)aAc>aGc	p.N402S	SCEL_ENST00000377246.3_Missense_Mutation_p.N424S|SCEL_ENST00000349847.3_Missense_Mutation_p.N444S|SCEL_ENST00000469982.1_3'UTR	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	444	16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		AACAGAACTAACCAAGGGTAA	0.393000													13	33					0	0	0.500413	0	0
LRRK2	120892	broad.mit.edu	37	12	40758797	40758797	+	Silent	SNP	A	A	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:40758797A>T	ENST00000298910.7	+	49	7393	c.7335A>T	c.(7333-7335)atA>atT	p.I2445I		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2445					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GTCGACTTATACGTGTAATTT	0.398000													13	31					0	0	0.457914	0	0
ACTC1	70	broad.mit.edu	37	15	35083365	35083365	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:35083365G>A	ENST00000290378.4	-	6	1595	c.940C>T	c.(940-942)Cgt>Tgt	p.R314C	RP11-814P5.1_ENST00000503496.1_RNA|ACTC1_ENST00000557860.1_5'UTR	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	314			R -> H (in CMD1R).		apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TTCTGCATACGATCAGCAATA	0.438000													82	164					0	0	0.870114	0	0
FAR2P1	440905	broad.mit.edu	37	2	130792775	130792775	+	RNA	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:130792775G>A	ENST00000325390.3	-	0	2553					NR_026758.1																						CCTGGAATTGGAATTAAGTCT	0.463000													7	17					0	0	0.248553	0	0
OR4C12	283093	broad.mit.edu	37	11	50003708	50003708	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:50003708G>A	ENST00000335238.4	-	1	363	c.330C>T	c.(328-330)atC>atT	p.I110I		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						TCAGCAGGATGATCTCAGTAG	0.458000													48	108					0	0	0.870114	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													4	69					0	0	0.150653	0	0
S100A7L2	645922	broad.mit.edu	37	1	153409535	153409535	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:153409535C>T	ENST00000368725.2	-	3	337	c.338G>A	c.(337-339)tGa>tAa	p.*113*		NM_001045479.1	NP_001038944.2			S100 calcium binding protein A7-like 2											NS(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	8	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGGTGGGATCACTGGCTTCC	0.498000													49	371					0	0	0.870114	0	0
ZFHX4	79776	broad.mit.edu	37	8	77618318	77618318	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr8:77618318G>A	ENST00000521891.2	+	2	2443	c.1995G>A	c.(1993-1995)gaG>gaA	p.E665E	ZFHX4_ENST00000518282.1_Silent_p.E665E|ZFHX4_ENST00000455469.2_Silent_p.E665E|ZFHX4_ENST00000050961.6_Silent_p.E665E|ZFHX4_ENST00000517683.1_Intron	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	665						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATATGAAGGAGAAACACCCTG	0.502000										HNSCC(33;0.089)			16	35					0	0	0.500413	0	0
UGT2A2	574537	broad.mit.edu	37	4	70505018	70505018	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:70505018C>T	ENST00000457664.2	-	1	340	c.341G>A	c.(340-342)tGg>tAg	p.W114*	UGT2A1_ENST00000503640.1_Intron|UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000514019.1_Nonsense_Mutation_p.W315*|UGT2A1_ENST00000512704.1_Intron	NM_001105677.2	NP_001099147.2																					GTAGAAAGCCCATATTGTGAG	0.368000													28	71					0	0	0.740014	0	0
B3GALT1	8708	broad.mit.edu	37	2	168725727	168725727	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:168725727C>T	ENST00000305861.1	+	2	529	c.178C>T	c.(178-180)Cca>Tca	p.P60S	AC016723.4_ENST00000436982.2_RNA|AC016723.4_ENST00000430546.1_RNA|B3GALT1_ENST00000392690.2_Missense_Mutation_p.P60S	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	60					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						ACCTATCAACCCACATTCTTT	0.413000													20	74					0	0	0.575678	0	0
XRCC3	7517	broad.mit.edu	37	14	104174866	104174866	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr14:104174866G>A	ENST00000553264.1	-	3	982	c.186C>T	c.(184-186)atC>atT	p.I62I	XRCC3_ENST00000554974.1_Intron|XRCC3_ENST00000352127.7_Silent_p.I62I|XRCC3_ENST00000555055.1_Silent_p.I62I|XRCC3_ENST00000554913.1_Silent_p.I62I|XRCC3_ENST00000445556.1_Silent_p.I62I			O43542	XRCC3_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 3	62					DNA recombination|DNA repair	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Melanoma(154;0.155)|all_epithelial(191;0.19)		Epithelial(152;0.239)		TACCTGTAAGGATGCTGCTTC	0.597000								Direct reversal of damage;Homologous recombination					9	19					0	0	0.335167	0	0
DMD	1756	broad.mit.edu	37	X	31196841	31196841	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chrX:31196841G>A	ENST00000357033.4	-	70	10374	c.10168C>T	c.(10168-10170)Ccc>Tcc	p.P3390S	DMD_ENST00000343523.2_Missense_Mutation_p.P930S|DMD_ENST00000378707.3_Missense_Mutation_p.P930S|DMD_ENST00000541735.1_Missense_Mutation_p.P930S|DMD_ENST00000378677.2_Missense_Mutation_p.P3386S|DMD_ENST00000378702.4_Missense_Mutation_p.P322S|DMD_ENST00000378723.3_Missense_Mutation_p.P322S|DMD_ENST00000378680.2_Missense_Mutation_p.P322S|DMD_ENST00000474231.1_Missense_Mutation_p.P930S|DMD_ENST00000359836.1_Missense_Mutation_p.P930S|DMD_ENST00000361471.4_Missense_Mutation_p.P322S	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3390	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCCATTCGGGGATGCTTCGCA	0.428000													57	21					0	0	0.870114	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77398242	77398242	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:77398242C>T	ENST00000282849.5	-	5	1233	c.815G>A	c.(814-816)aGg>aAg	p.R272K		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	272					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTCATCAAACCTTAGATAGGT	0.468000													13	32					0	0	0.411799	0	0
CERS4	79603	broad.mit.edu	37	19	8322868	8322868	+	Splice_Site	SNP	C	C	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:8322868C>G	ENST00000558331.1	+	10	1153	c.695_splice	c.e10+1	p.Q232_splice	CERS4_ENST00000559450.1_Splice_Site_p.Q283_splice|CERS4_ENST00000559336.1_Intron|CERS4_ENST00000595722.1_3'UTR|CERS4_ENST00000251363.5_Splice_Site_p.Q283_splice			Q9HA82	CERS4_HUMAN	ceramide synthase 4	283	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CTTTCCCACCCAGTGAGTCAG	0.562000													29	57					0	0	0.717897	0	0
KIF2A	3796	broad.mit.edu	37	5	61642984	61642984	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:61642984C>T	ENST00000381103.2	+	3	517	c.32C>T	c.(31-33)tCt>tTt	p.S11F	KIF2A_ENST00000506857.1_Missense_Mutation_p.S4F|KIF2A_ENST00000407818.3_Missense_Mutation_p.S31F|KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000401507.3_Missense_Mutation_p.S31F	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	31	Globular (Potential).				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		ATGGTAACATCTTTAAATGAA	0.323000													4	11					0	0	0.150653	0	0
FBXO5	26271	broad.mit.edu	37	6	153296353	153296353	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr6:153296353G>A	ENST00000367241.3	-	2	749	c.369C>T	c.(367-369)ttC>ttT	p.F123F	FBXO5_ENST00000229758.3_Silent_p.F169F	NM_001142522.1	NP_001135994.1	Q9UKT4	FBX5_HUMAN	F-box protein 5	169					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	15		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		GACTGTCACCGAAATTCTCCT	0.423000													18	38					0	0	0.575678	0	0
NLRP11	204801	broad.mit.edu	37	19	56321050	56321050	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:56321050A>C	ENST00000443188.1	-	5	1636	c.926T>G	c.(925-927)tTt>tGt	p.F309C	NLRP11_ENST00000592953.1_Missense_Mutation_p.F210C|NLRP11_ENST00000589824.2_Missense_Mutation_p.F309C|NLRP11_ENST00000360133.3_Missense_Mutation_p.F309C|NLRP11_ENST00000589093.1_Missense_Mutation_p.F309C	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	309	NACHT.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GAAAGAGTTAAAATATATCTC	0.493000													14	31					0	0	0.520397	0	0
MUC5B	727897	broad.mit.edu	37	11	1265406	1265406	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:1265406G>A	ENST00000447027.1	+	31	7363	c.7305G>A	c.(7303-7305)acG>acA	p.T2435T	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Silent_p.T2432T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2432	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCGGGGACGACCTGGATCC	0.627000													36	73					0	0	0.870114	0	0
PDZD2	23037	broad.mit.edu	37	5	32074487	32074487	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:32074487G>A	ENST00000438447.1	+	18	3663	c.3275G>A	c.(3274-3276)cGt>cAt	p.R1092H	PDZD2_ENST00000282493.3_Missense_Mutation_p.R1092H			O15018	PDZD2_HUMAN	PDZ domain containing 2	1092					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						TACACAGTCCGTACAGACACC	0.597000													16	71					0	0	0.500413	0	0
RNF151	146310	broad.mit.edu	37	16	2017795	2017795	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:2017795G>A	ENST00000569714.1	+	3	227	c.219G>A	c.(217-219)cgG>cgA	p.R73R	RNF151_ENST00000569210.2_Intron|RNF151_ENST00000321392.3_Silent_p.R72R	NM_174903.4	NP_777563.2	Q2KHN1	RN151_HUMAN	ring finger protein 151	73					cell differentiation|spermatogenesis	cytoplasm|nucleus	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(1)	2						ATAAACTCCGGAAAACCATTG	0.527000													10	5					0	0	0.435327	0	0
CTAGE1	64693	broad.mit.edu	37	18	19997039	19997039	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr18:19997039C>T	ENST00000391403.2	-	1	839	c.736G>A	c.(736-738)Gat>Aat	p.D246N		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	246						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GCAACCCCATCTTTCATCTTT	0.368000													31	80					0	0	0.779181	0	0
SCN10A	6336	broad.mit.edu	37	3	38743504	38743504	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:38743504C>T	ENST00000449082.2	-	26	4482	c.4483G>A	c.(4483-4485)Gtg>Atg	p.V1495M		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1495					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCAGTCTCCACCATCATGGTG	0.443000													18	41					0	0	0.520397	0	0
PCED1B	91523	broad.mit.edu	37	12	47629874	47629874	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:47629874C>T	ENST00000546455.1	+	4	1759	c.1028C>T	c.(1027-1029)tCc>tTc	p.S343F	PCED1B_ENST00000432328.1_Missense_Mutation_p.S343F					PC-esterase domain containing 1B									p.S343F(1)									GCCTGTTTTTCCTCAGACCAT	0.542000													23	133					0	0	0.654019	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3389979	3389979	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:3389979G>T	ENST00000378378.4	+	8	1603	c.1198G>T	c.(1198-1200)Gag>Tag	p.E400*	ARHGEF16_ENST00000378371.2_Nonsense_Mutation_p.E112*|ARHGEF16_ENST00000378373.1_Nonsense_Mutation_p.E112*|ARHGEF16_ENST00000413250.2_Nonsense_Mutation_p.E104*	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	400	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		CGCCTTCCGAGAGGCCCTGAG	0.647000													4	65					0.00909568	0.00919712	0.150653	1	0
SLC12A8	84561	broad.mit.edu	37	3	124826446	124826446	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:124826446C>T	ENST00000423114.2	-	10	1670	c.1671G>A	c.(1669-1671)tgG>tgA	p.W557*	SLC12A8_ENST00000465475.1_5'UTR|SLC12A8_ENST00000314584.7_Nonsense_Mutation_p.W281*|SLC12A8_ENST00000469902.1_Nonsense_Mutation_p.W528*|SLC12A8_ENST00000393469.4_Nonsense_Mutation_p.W528*|SLC12A8_ENST00000430155.2_Nonsense_Mutation_p.W329*			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	528					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						CCTGCCCCTCCCAGGAGGCAG	0.562000													31	50					0	0	0.729181	0	0
UNC13A	23025	broad.mit.edu	37	19	17766723	17766723	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:17766723G>A	ENST00000428389.2	-	11	1515	c.1516C>T	c.(1516-1518)Cct>Tct	p.P506S	UNC13A_ENST00000252773.7_Missense_Mutation_p.P418S|UNC13A_ENST00000519716.2_Missense_Mutation_p.P418S|UNC13A_ENST00000552293.1_Missense_Mutation_p.P418S|UNC13A_ENST00000551649.1_Missense_Mutation_p.P418S|UNC13A_ENST00000550896.1_Missense_Mutation_p.P418S			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	418					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						TCAGCCTCAGGGATCTGCTCA	0.677000													6	14					0	0	0.217242	0	0
ACSS3	79611	broad.mit.edu	37	12	81647355	81647355	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:81647355G>A	ENST00000548058.1	+	15	2811	c.1901G>A	c.(1900-1902)cGa>cAa	p.R634Q	ACSS3_ENST00000261206.3_Missense_Mutation_p.R633Q|ACSS3_ENST00000548324.1_Missense_Mutation_p.R316Q			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	634						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GCTGCTTTTCGAAATGCAGTG	0.423000													26	43					0	0	0.717897	0	0
OR13F1	138805	broad.mit.edu	37	9	107267485	107267485	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:107267485C>T	ENST00000334726.2	+	1	1031	c.942C>T	c.(940-942)ttC>ttT	p.F314F		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATACTGCCTTCATTTCCATCC	0.338000													21	30					0	0	0.624587	0	0
LRP1B	53353	broad.mit.edu	37	2	141243044	141243044	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:141243044C>T	ENST00000389484.3	-	59	10264	c.9293G>A	c.(9292-9294)gGa>gAa	p.G3098E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3098					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGGTTTTTTCCAATCCAATC	0.373000										TSP Lung(27;0.18)			10	30					0	0	0.411799	0	0
TRIM17	51127	broad.mit.edu	37	1	228596850	228596850	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:228596850C>T	ENST00000456946.2	-	6	1281	c.906G>A	c.(904-906)agG>agA	p.R302R	TRIM17_ENST00000295033.3_Intron|RP11-245P10.4_ENST00000436779.1_RNA|TRIM17_ENST00000366698.2_Intron|TRIM17_ENST00000366697.2_Intron	NM_001134855.1	NP_001128327.1	Q9Y577	TRI17_HUMAN	tripartite motif containing 17	302	B30.2/SPRY.				protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	10		Prostate(94;0.0724)				GGTCAGAGGTCCTGGCCCTGG	0.607000													16	170					0	0	0.479597	0	0
SETDB1	9869	broad.mit.edu	37	1	150921738	150921738	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:150921738C>T	ENST00000271640.5	+	11	1598	c.1408C>T	c.(1408-1410)Caa>Taa	p.Q470*	SETDB1_ENST00000459773.1_Intron|SETDB1_ENST00000368969.4_Nonsense_Mutation_p.Q470*	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	470					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTATCCCCCCAAGCAGGTGA	0.488000													47	30					0	0	0.870114	0	0
MARCH11	441061	broad.mit.edu	37	5	16091177	16091177	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:16091177G>A	ENST00000332432.8	-	3	906	c.707C>T	c.(706-708)tCt>tTt	p.S236F	MARCH11_ENST00000505509.1_5'UTR	NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	236						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						CAGTGTTATAGAAATGCTCTG	0.393000													4	4					0	0	0.150653	0	0
WDR90	197335	broad.mit.edu	37	16	715626	715626	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:715626C>T	ENST00000547944.1	+	1	443	c.56C>T	c.(55-57)cCc>cTc	p.P19L	WDR90_ENST00000549091.1_Intron|WDR90_ENST00000315764.4_Missense_Mutation_p.P19L|WDR90_ENST00000293879.4_Intron|WDR90_ENST00000547543.1_Intron			Q96KV7	WDR90_HUMAN	WD repeat domain 90	600										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				TGCCTGCGTCCCTTTACCCTG	0.652000													21	29					0	0	0.624587	0	0
MYH4	4622	broad.mit.edu	37	17	10351212	10351212	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:10351212C>T	ENST00000255381.2	-	34	4998	c.4888G>A	c.(4888-4890)Gaa>Aaa	p.E1630K	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1630					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						AGCTGGATTTCCATTTCATTA	0.453000													76	86					0	0	0.870114	0	0
GRM3	2913	broad.mit.edu	37	7	86415890	86415890	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr7:86415890G>A	ENST00000361669.2	+	3	1881	c.782G>A	c.(781-783)cGa>cAa	p.R261Q	AC005009.2_ENST00000452471.1_RNA|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000536043.1_Missense_Mutation_p.R133Q|GRM3_ENST00000439827.1_Missense_Mutation_p.R261Q|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000394720.2_Missense_Mutation_p.R259Q	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	261					synaptic transmission	integral to plasma membrane		p.R261L(1)		NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AGCGTGATCCGAGAACTGTTG	0.652000													23	39					0	0	0.654019	0	0
TANGO6	79613	broad.mit.edu	37	16	68961693	68961693	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:68961693C>T	ENST00000261778.1	+	13	2362	c.2350C>T	c.(2350-2352)Cat>Tat	p.H784Y	RP11-521L9.1_ENST00000562790.1_lincRNA	NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		ACAAACCAGTCATGAAAGACC	0.512000													10	48					0	0	0.361761	0	0
ETV6	2120	broad.mit.edu	37	12	12022522	12022522	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:12022522C>T	ENST00000396373.4	+	5	902	c.628C>T	c.(628-630)Cgc>Tgc	p.R210C		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	210						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CAACATGATCCGCCGCCTCTC	0.622000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								70	46					0	0	0.870114	0	0
NDN	4692	broad.mit.edu	37	15	23932118	23932118	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:23932118G>A	ENST00000331837.4	-	1	332	c.247C>T	c.(247-249)Ccg>Tcg	p.P83S		NM_002487.2	NP_002478.1	Q99608	NECD_HUMAN	necdin, melanoma antigen (MAGE) family member	83					negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|skin(1)	39		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		GCCGCGCTCGGGGCCTGGTGG	0.761000									Prader-Willi syndrome				3	12					0	0	0.115264	0	0
GRHPR	9380	broad.mit.edu	37	9	37426560	37426560	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:37426560G>C	ENST00000607784.1	+	4	318	c.313G>C	c.(313-315)Gat>Cat	p.D105H	GRHPR_ENST00000493368.1_3'UTR|GRHPR_ENST00000318158.6_Missense_Mutation_p.D105H			Q9UBQ7	GRHPR_HUMAN	glyoxylate reductase/hydroxypyruvate reductase	105					cellular nitrogen compound metabolic process|excretion|glyoxylate metabolic process	peroxisomal matrix	glycerate dehydrogenase activity|glyoxylate reductase (NADP) activity|hydroxypyruvate reductase activity|NAD binding|protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12				GBM - Glioblastoma multiforme(29;0.00687)		CTACACCCCAGATGTCCTGAC	0.527000													40	94					0	0	0.853193	0	0
NAA60	79903	broad.mit.edu	37	16	3533560	3533560	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:3533560C>T	ENST00000407558.4	+	6	838	c.535C>T	c.(535-537)Ctc>Ttc	p.L179F	NAA60_ENST00000414063.2_Missense_Mutation_p.L179F|NAA60_ENST00000421765.3_Intron|NAA60_ENST00000577013.1_Intron|LA16c-306E5.3_ENST00000574423.2_RNA|NAA60_ENST00000576916.1_Intron|NAA60_ENST00000573580.1_Missense_Mutation_p.L114F|NAA60_ENST00000575076.1_Missense_Mutation_p.L179F|LA16c-306E5.2_ENST00000575785.1_RNA|NAA60_ENST00000360862.5_Missense_Mutation_p.L114F|NAA60_ENST00000570551.1_3'UTR|NAA60_ENST00000570819.1_Intron|NAA60_ENST00000572584.1_Missense_Mutation_p.L179F|NAA60_ENST00000424546.2_Missense_Mutation_p.L186F|NAA60_ENST00000572942.1_Intron	NM_001083601.1	NP_001077070.1	Q9H7X0	NAT15_HUMAN	N(alpha)-acetyltransferase 60, NatF catalytic subunit	179	N-acetyltransferase.						N-acetyltransferase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)	7						CACCTATGTCCTCTACATCAA	0.498000													8	40					0	0	0.278610	0	0
TRBV6-7	28600	broad.mit.edu	37	7	142144058	142144058	+	RNA	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr7:142144058C>T	ENST00000390373.2	-	0	26																											GAGAAAAGGCCACACAGCACA	0.602000													4	110					0	0	0.307466	0	0
KNSTRN	90417	broad.mit.edu	37	15	40675107	40675107	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:40675107C>T	ENST00000416151.2	+	1	186	c.71C>T	c.(70-72)tCc>tTc	p.S24F	KNSTRN_ENST00000448395.2_Missense_Mutation_p.S24F|KNSTRN_ENST00000249776.8_Missense_Mutation_p.S24F	NM_001142761.1	NP_001136233.1			kinetochore-localized astrin/SPAG5 binding protein									p.S24F(1)									GAGTGCGATTCCCACCCACTT	0.567000													14	48					0	0	0.457914	0	0
OR5P2	120065	broad.mit.edu	37	11	7818394	7818394	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:7818394C>T	ENST00000329434.2	-	1	126	c.96G>A	c.(94-96)atG>atA	p.M32I	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153444.1	NP_703145.1	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P, member 2	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M32I(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	22				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ATAGGATGATCATGAAGAGGA	0.433000													14	35					0	0	0.479597	0	0
SEMA3E	9723	broad.mit.edu	37	7	82996917	82996917	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr7:82996917G>T	ENST00000307792.3	-	17	2780	c.2313C>A	c.(2311-2313)caC>caA	p.H771Q	SEMA3E_ENST00000427262.1_Missense_Mutation_p.H711Q	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	771					axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				AGTCCAGCGTGTGCCTGGGCA	0.418000													38	127					8.16277e-20	8.47433e-20	0.827153	1	0
ARMC4	55130	broad.mit.edu	37	10	28272791	28272791	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr10:28272791C>T	ENST00000305242.5	-	6	892	c.800G>A	c.(799-801)gGa>gAa	p.G267E	ARMC4_ENST00000239715.3_Missense_Mutation_p.G124E	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	267							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						AAATACTCCTCCTGCACTGCA	0.433000													13	25					0	0	0.479597	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32217709	32217709	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:32217709C>T	ENST00000346541.3	+	9	1781	c.1244C>T	c.(1243-1245)tCt>tTt	p.S415F	CBFA2T2_ENST00000375279.2_Missense_Mutation_p.S415F|CBFA2T2_ENST00000397800.1_Missense_Mutation_p.S386F|CBFA2T2_ENST00000342704.5_Missense_Mutation_p.S406F|CBFA2T2_ENST00000491618.1_3'UTR|CBFA2T2_ENST00000359606.3_Missense_Mutation_p.S425F	NM_005093.3	NP_005084.1	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	415						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)	20						AGTGCAGATTCTCTCAGCAAT	0.488000													17	20					0	0	0.500413	0	0
COX10	1352	broad.mit.edu	37	17	13980198	13980198	+	Translation_Start_Site	SNP	T	T	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:13980198T>A	ENST00000536205.1	+	0	326				COX10_ENST00000537334.1_Intron|COX10_ENST00000429152.2_Silent_p.S108S|COX10_ENST00000261643.3_Silent_p.S108S			Q12887	COX10_HUMAN	cytochrome c oxidase assembly homolog 10 (yeast)						heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		CCAGCCTATCTTTGTCCAGAA	0.418000													11	26					0	0	0.411799	0	0
LZTR1	8216	broad.mit.edu	37	22	21344765	21344765	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr22:21344765G>A	ENST00000215739.8	+	8	1101	c.742G>A	c.(742-744)Gga>Aga	p.G248R	LZTR1_ENST00000389355.3_Missense_Mutation_p.G229R|LZTR1_ENST00000479606.1_3'UTR	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	248					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity	p.G248R(1)		breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGGGCAAAGCGGAGCCAAAAT	0.562000													30	95					0	0	0.760397	0	0
PNPLA7	375775	broad.mit.edu	37	9	140389554	140389554	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:140389554G>A	ENST00000406427.1	-	19	2394	c.2058C>T	c.(2056-2058)gcC>gcT	p.A686A	PNPLA7_ENST00000277531.4_Silent_p.A661A|PNPLA7_ENST00000371457.1_Silent_p.A267A	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	661					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		AGTCCCGAACGGCATGCACCG	0.692000													29	72					0	0	0.788014	0	0
TCL1A	8115	broad.mit.edu	37	14	96178600	96178600	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr14:96178600C>T	ENST00000402399.1	-	2	383	c.254G>A	c.(253-255)cGa>cAa	p.R85Q	TCL1A_ENST00000555202.1_Missense_Mutation_p.R85Q|RP11-164H13.1_ENST00000547644.2_RNA|RP11-164H13.1_ENST00000553445.1_RNA|TCL1A_ENST00000556450.1_Missense_Mutation_p.R85Q|TCL1A_ENST00000554012.1_Missense_Mutation_p.R85Q	NM_021966.2	NP_068801.1	P56279	TCL1A_HUMAN	T-cell leukemia/lymphoma 1A	85					multicellular organismal development	endoplasmic reticulum|microsome				haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|prostate(1)|skin(1)	12		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		GTCTGAGGATCGGTATCGTCC	0.577000			T	TRA@	T-CLL								26	120					0	0	0.717897	0	0
TBX10	347853	broad.mit.edu	37	11	67401726	67401726	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:67401726C>T	ENST00000335385.3	-	4	570	c.483G>A	c.(481-483)tgG>tgA	p.W161*		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	161					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						TCTGGCGCATCCACTGGGCAC	0.662000													32	188					0	0	0.750413	0	0
AHCTF1	25909	broad.mit.edu	37	1	247027368	247027368	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:247027368T>C	ENST00000366508.1	-	27	3639	c.3503A>G	c.(3502-3504)gAg>gGg	p.E1168G	AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000391829.2_Missense_Mutation_p.E1133G|AHCTF1_ENST00000326225.3_Missense_Mutation_p.E1142G			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1133	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CTGAATAAACTCCGAACACTG	0.443000													9	78					0	0	0.307466	0	0
GPR115	221393	broad.mit.edu	37	6	47682712	47682712	+	Silent	SNP	T	T	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr6:47682712T>A	ENST00000283303.2	+	6	1989	c.1731T>A	c.(1729-1731)gtT>gtA	p.V577V	GPR115_ENST00000371220.1_Silent_p.V634V|GPR115_ENST00000327753.3_Silent_p.V577V	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	577					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						TGATTGTGGTTTTGGTTGTTG	0.468000													113	78					0	0	0.870114	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54894364	54894364	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:54894364C>T	ENST00000293373.6	+	3	340	c.261C>T	c.(259-261)ttC>ttT	p.F87F	NCKAP1L_ENST00000545638.2_Silent_p.F37F	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	87					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						TAATTAGATTCCTCACCAACT	0.388000													32	55					0	0	0.796494	0	0
VWA2	340706	broad.mit.edu	37	10	116038498	116038498	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr10:116038498C>G	ENST00000603594.1	+	8	1042	c.721C>G	c.(721-723)Ccc>Gcc	p.P241A	VWA2_ENST00000392982.3_Missense_Mutation_p.P241A	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	241						extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		CGAGGCTCACCCCTGTGAGCA	0.647000													27	67					0	0	0.706142	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155920754	155920754	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:155920754G>A	ENST00000368316.1	-	24	2955	c.2485C>T	c.(2485-2487)Cga>Tga	p.R829*	ARHGEF2_ENST00000313695.7_Nonsense_Mutation_p.R829*|ARHGEF2_ENST00000361247.4_Nonsense_Mutation_p.R857*|ARHGEF2_ENST00000313667.4_Nonsense_Mutation_p.R856*|ARHGEF2_ENST00000368315.3_Nonsense_Mutation_p.R858*			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	857					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGCTGCCTTCGAGCCTCTTCG	0.726000													29	15					0	0	0.729181	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319155	21319155	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:21319155C>T	ENST00000583088.1	+	3	1396	c.501C>T	c.(499-501)atC>atT	p.I167I	KCNJ12_ENST00000331718.5_Silent_p.I167I	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CCCAGTCCATCGTGGGCTGCA	0.617000										Prostate(3;0.18)			4	64					0	0	0.150653	0	0
MAP4K3	8491	broad.mit.edu	37	2	39515377	39515377	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:39515377A>C	ENST00000263881.3	-	20	1683	c.1359T>G	c.(1357-1359)gaT>gaG	p.D453E	MAP4K3_ENST00000536018.1_Missense_Mutation_p.D6E|MAP4K3_ENST00000437545.1_Missense_Mutation_p.D369E|MAP4K3_ENST00000341681.5_Missense_Mutation_p.D432E	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	453					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				CTTGATTTTCATCCTCAGTAG	0.423000													35	84					0	0	0.847076	0	0
TEKT5	146279	broad.mit.edu	37	16	10721648	10721648	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:10721648T>G	ENST00000283025.2	-	7	1321	c.1250A>C	c.(1249-1251)aAc>aCc	p.N417T	TEKT5_ENST00000574923.1_5'UTR	NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	417					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						GAACACCTCGTTCACCAGCCT	0.542000													7	39					0	0	0.248553	0	0
MYH4	4622	broad.mit.edu	37	17	10352194	10352194	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:10352194C>T	ENST00000255381.2	-	31	4462	c.4352G>A	c.(4351-4353)aGa>aAa	p.R1451K	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1451					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTCAAAGTTTCTTTGCTTCTT	0.438000													12	39					0	0	0.479597	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320607	79320607	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:79320607T>C	ENST00000428286.1	-	8	6706	c.5506A>G	c.(5506-5508)Ata>Gta	p.I1836V	PRUNE2_ENST00000376718.3_Missense_Mutation_p.I2195V			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2195					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCACCGTTTATTTCAGAAGGT	0.458000													31	82					0	0	0.750413	0	0
SLC13A3	64849	broad.mit.edu	37	20	45221138	45221138	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:45221138G>A	ENST00000279027.4	-	6	843	c.825C>T	c.(823-825)ttC>ttT	p.F275F	SLC13A3_ENST00000435032.1_5'UTR|SLC13A3_ENST00000495082.1_Silent_p.F228F|SLC13A3_ENST00000290317.5_Silent_p.F228F|SLC13A3_ENST00000396360.1_Silent_p.F228F|SLC13A3_ENST00000413164.2_Intron|SLC13A3_ENST00000372121.1_Intron|SLC13A3_ENST00000472148.1_Silent_p.F228F	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	275						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	ACCAGGAGCCGAAATTCACCA	0.562000													11	55					0	0	0.361761	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004445	75004445	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chrX:75004445C>T	ENST00000373359.2	-	1	634	c.442G>A	c.(442-444)Gat>Aat	p.D148N		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	148	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GCCTGAGGATCAATAACTCTC	0.517000													10	3					0	0	0.335167	0	0
JMJD1C	221037	broad.mit.edu	37	10	64977081	64977081	+	Silent	SNP	G	G	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr10:64977081G>C	ENST00000399262.2	-	5	782	c.564C>G	c.(562-564)tcC>tcG	p.S188S	JMJD1C_ENST00000489372.2_5'UTR|JMJD1C_ENST00000402544.1_5'UTR|JMJD1C_ENST00000542921.1_Silent_p.S6S|JMJD1C_ENST00000399251.1_5'UTR	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	188					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					ATCCATTTAAGGAATAAGGAC	0.368000													9	32					0	0	0.307466	0	0
BATF2	116071	broad.mit.edu	37	11	64761963	64761963	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:64761963C>T	ENST00000301887.4	-	2	228	c.98G>A	c.(97-99)cGa>cAa	p.R33Q		NM_138456.3	NP_612465.3	Q8N1L9	BATF2_HUMAN	basic leucine zipper transcription factor, ATF-like 2	33						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|skin(1)	9						CTGCCGGCTTCGCTGGGCGGC	0.632000													7	11					0	0	0.335167	0	0
CXorf67	340602	broad.mit.edu	37	X	51151078	51151078	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chrX:51151078G>A	ENST00000342995.2	+	1	1312	c.1210G>A	c.(1210-1212)Gtc>Atc	p.V404I						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						TTGGCATGCAGTCCGTATGCG	0.592000													19	9					0	0	0.575678	0	0
RIN2	54453	broad.mit.edu	37	20	19955650	19955650	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:19955650G>A	ENST00000255006.6	+	8	1277	c.1128G>A	c.(1126-1128)agG>agA	p.R376R	RIN2_ENST00000484638.1_3'UTR|RIN2_ENST00000440354.2_Intron	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	327					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						GGCTGGCCAGGACTGAAACCC	0.612000													15	55					0	0	0.520397	0	0
DMRTA1	63951	broad.mit.edu	37	9	22447722	22447722	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:22447722G>A	ENST00000325870.1	+	1	883	c.658G>A	c.(658-660)Gaa>Aaa	p.E220K		NM_022160.2	NP_071443.2	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	220					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		TTATCCTGAGGAAAAACAAGG	0.552000													13	9					0	0	0.411799	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61299387	61299387	+	Silent	SNP	C	C	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:61299387C>A	ENST00000217159.1	+	9	1867	c.1662C>A	c.(1660-1662)atC>atA	p.I554I	SLCO4A1_ENST00000370507.1_Silent_p.I554I|SLCO4A1_ENST00000470412.1_3'UTR	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	554	Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			GTAGCTGTATCCCTCAGAATC	0.537000													25	120					1.17739e-12	1.21307e-12	0.693898	1	0
ANXA10	11199	broad.mit.edu	37	4	169049311	169049311	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:169049311G>A	ENST00000359299.3	+	2	281	c.95G>A	c.(94-96)gGa>gAa	p.G32E		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	32							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		GCACTCCAAGGATTTGGTAAG	0.378000													25	32					0	0	0.667858	0	0
C1orf127	148345	broad.mit.edu	37	1	11008241	11008241	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:11008241C>T	ENST00000377004.4	-	12	1950	c.1951G>A	c.(1951-1953)Gac>Aac	p.D651N	C1orf127_ENST00000377008.4_Missense_Mutation_p.D484N	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	502										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CCCTCTATGTCCTGGCTTGGT	0.647000													29	46					0	0	0.779181	0	0
TTN	7273	broad.mit.edu	37	2	179451422	179451422	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:179451422G>A	ENST00000589042.1	-	308	64430	c.64206C>T	c.(64204-64206)atC>atT	p.I21402I	TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Silent_p.I12337I|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342992.6_Silent_p.I18834I|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342175.6_Silent_p.I12529I|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000359218.5_Silent_p.I12462I|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.I19761I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19761	Fibronectin type-III 55.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAACTAGTGATGTAGCCAT	0.478000													46	76					0	0	0.847076	0	0
PGS1	9489	broad.mit.edu	37	17	76395526	76395526	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:76395526G>A	ENST00000262764.6	+	5	635	c.609G>A	c.(607-609)ctG>ctA	p.L203L	PGS1_ENST00000329897.7_Silent_p.L68L|PGS1_ENST00000588281.1_3'UTR	NM_024419.3	NP_077733.3	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	203					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	10			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			TCCGTGGGCTGCTTCGGCTCC	0.612000													29	74					0	0	0.729181	0	0
KIRREL2	84063	broad.mit.edu	37	19	36351511	36351511	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:36351511C>T	ENST00000360202.5	+	7	1068	c.870C>T	c.(868-870)tcC>tcT	p.S290S	NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000262625.7_Silent_p.S290S|KIRREL2_ENST00000586102.2_Silent_p.S270S|KIRREL2_ENST00000347900.6_Silent_p.S240S|KIRREL2_ENST00000592409.1_Silent_p.S290S	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	290	Ig-like C2-type 3.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGCCCGTGTCCTGCGAGGTCA	0.662000													21	88					0	0	0.639603	0	0
DLL3	10683	broad.mit.edu	37	19	39998572	39998572	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:39998572C>T	ENST00000205143.4	+	8	1783	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F	DLL3_ENST00000356433.5_Intron	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)	592					Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGCCCCTTTTCCCCCCGCTAC	0.552000													23	24					0	0	0.624587	0	0
ARL16	339231	broad.mit.edu	37	17	79650840	79650840	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:79650840C>T	ENST00000397498.4	-	1	114	c.16G>A	c.(16-18)Ggg>Agg	p.G6R		NM_001040025.1	NP_001035114.1	Q0P5N6	ARL16_HUMAN	ADP-ribosylation factor-like 16	6							GTP binding	p.G6R(1)		central_nervous_system(1)|endometrium(1)|lung(4)|skin(1)	7	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AAGGCCCGCCCACCGGCCACT	0.637000													24	15					0	0	0.693898	0	0
TAF1L	138474	broad.mit.edu	37	9	32633798	32633798	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:32633798G>A	ENST00000242310.4	-	1	1869	c.1780C>T	c.(1780-1782)Ccc>Tcc	p.P594S	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	594					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGTTGCTTGGGGAAATAATAC	0.483000													56	141					0	0	0.870114	0	0
WDR59	79726	broad.mit.edu	37	16	74946209	74946209	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:74946209G>A	ENST00000262144.6	-	14	1406	c.1276C>T	c.(1276-1278)Cgt>Tgt	p.R426C		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	426	RWD.									breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						ATCTTGACACGATGGTTGCTG	0.502000													37	45					0	0	0.812448	0	0
CACNA1D	776	broad.mit.edu	37	3	53820920	53820920	+	Missense_Mutation	SNP	C	C	T	rs145414503		TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:53820920C>T	ENST00000288139.3	+	41	5042	c.4924C>T	c.(4924-4926)Cgg>Tgg	p.R1642W	CACNA1D_ENST00000540742.1_Missense_Mutation_p.R514W|CACNA1D_ENST00000422281.2_Missense_Mutation_p.R1607W|CACNA1D_ENST00000350061.5_Missense_Mutation_p.R1622W	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1622					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.R1642W(1)		breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ATTCAAGAAACGGAAAGAACA	0.443000													10	35					0	0	0.335167	0	0
KCNG1	3755	broad.mit.edu	37	20	49626128	49626128	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:49626128G>A	ENST00000371571.4	-	2	1033	c.748C>T	c.(748-750)Ccc>Tcc	p.P250S	RP5-955M13.4_ENST00000424566.1_RNA|KCNG1_ENST00000396017.3_Missense_Mutation_p.P250S	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	250						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						CTCAGGCTGGGCAAGGTGCTG	0.667000													5	37					0	0	0.217242	0	0
PPP6R3	55291	broad.mit.edu	37	11	68338522	68338522	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr11:68338522T>A	ENST00000393799.2	+	12	1560	c.1293T>A	c.(1291-1293)tgT>tgA	p.C431*	PPP6R3_ENST00000527403.2_Nonsense_Mutation_p.C431*|PPP6R3_ENST00000393800.2_Nonsense_Mutation_p.C431*|PPP6R3_ENST00000524845.1_Nonsense_Mutation_p.C431*|PPP6R3_ENST00000529710.1_Nonsense_Mutation_p.C380*|PPP6R3_ENST00000524904.1_Nonsense_Mutation_p.C431*|PPP6R3_ENST00000265637.4_Nonsense_Mutation_p.C431*|PPP6R3_ENST00000265636.5_Nonsense_Mutation_p.C380*|PPP6R3_ENST00000393801.3_Nonsense_Mutation_p.C431*|PPP6R3_ENST00000534534.1_Nonsense_Mutation_p.C199*			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	431					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TCCAAAAATGTCAATTAATAG	0.284000													4	26					0	0	0.150653	0	0
WDR72	256764	broad.mit.edu	37	15	53957929	53957929	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:53957929C>T	ENST00000396328.1	-	14	2041	c.1802G>A	c.(1801-1803)cGa>cAa	p.R601Q	WDR72_ENST00000557913.1_Missense_Mutation_p.R598Q|WDR72_ENST00000360509.5_Missense_Mutation_p.R601Q|WDR72_ENST00000559418.1_Missense_Mutation_p.R611Q	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	601										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		AAGAATAATTCGTGCTCTTTC	0.383000													13	23					0	0	0.435327	0	0
OR2G2	81470	broad.mit.edu	37	1	247752283	247752283	+	Missense_Mutation	SNP	C	C	T	rs145391203		TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:247752283C>T	ENST00000320065.1	+	1	622	c.622C>T	c.(622-624)Ctt>Ttt	p.L208F	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L208F(1)		endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GGCTAGTATCCTTTTCCTTAT	0.498000													13	117					0	0	0.411799	0	0
SYCE1	93426	broad.mit.edu	37	10	135368917	135368917	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr10:135368917C>T	ENST00000368517.3	-	12	886	c.748G>A	c.(748-750)Gga>Aga	p.G250R	SYCE1_ENST00000343131.5_Missense_Mutation_p.G286R|SYCE1_ENST00000432597.2_Missense_Mutation_p.G250R|SPRN_ENST00000541506.1_Intron	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	286					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		ACTTGCATTCCATGCTTTTCC	0.562000													46	76					0	0	0.870114	0	0
IQCF1	132141	broad.mit.edu	37	3	51929003	51929003	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:51929003C>T	ENST00000310914.5	-	4	583	c.521G>A	c.(520-522)aGa>aAa	p.R174K		NM_152397.2	NP_689610.2	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	174										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GGCTGTGACTCTGTACTGGCC	0.542000													47	91					0	0	0.864702	0	0
TTN	7273	broad.mit.edu	37	2	179433525	179433525	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:179433525C>T	ENST00000589042.1	-	326	77558	c.77334G>A	c.(77332-77334)ggG>ggA	p.G25778G	TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Silent_p.G16713G|TTN_ENST00000342992.6_Silent_p.G23210G|TTN_ENST00000342175.6_Silent_p.G16905G|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000359218.5_Silent_p.G16838G|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000591111.1_Silent_p.G24137G	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24137	Fibronectin type-III 87.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATCACTTCTCCCCTTTTCAT	0.428000													16	41					0	0	0.500413	0	0
SCN5A	6331	broad.mit.edu	37	3	38663950	38663950	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:38663950G>A	ENST00000413689.1	-	4	616	c.423C>T	c.(421-423)atC>atT	p.I141I	SCN5A_ENST00000449557.2_Silent_p.I141I|SCN5A_ENST00000450102.2_Silent_p.I141I|SCN5A_ENST00000333535.4_Silent_p.I141I|SCN5A_ENST00000423572.2_Silent_p.I141I|SCN5A_ENST00000451551.2_Silent_p.I141I|SCN5A_ENST00000425664.1_Silent_p.I141I|SCN5A_ENST00000414099.2_Silent_p.I141I|SCN5A_ENST00000443581.1_Silent_p.I141I|SCN5A_ENST00000455624.2_Silent_p.I141I	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	141					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGTTGGTGAGGATGGTGCACA	0.632000													5	11					0	0	0.217242	0	0
MUC16	94025	broad.mit.edu	37	19	9075414	9075414	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:9075414G>A	ENST00000397910.4	-	3	12235	c.12032C>T	c.(12031-12033)tCc>tTc	p.S4011F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4013	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTCAAGAAGGAATTAGGCTC	0.478000													11	51					0	0	0.361761	0	0
SLC34A1	6569	broad.mit.edu	37	5	176820745	176820745	+	Silent	SNP	A	A	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:176820745A>T	ENST00000324417.5	+	9	1078	c.987A>T	c.(985-987)ggA>ggT	p.G329G	SLC34A1_ENST00000513614.1_3'UTR	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	329					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGACCCTTGGAAATGCCACCA	0.562000													13	27					0	0	0.457914	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228679	57228679	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr8:57228679C>T	ENST00000396721.2	-	2	358	c.228G>A	c.(226-228)ggG>ggA	p.G76G	SDR16C5_ENST00000303749.3_Silent_p.G76G|SDR16C5_ENST00000522671.1_Silent_p.G76G			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	76					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						TTTCCTCATTCCCCTCCTTAT	0.522000													87	31					0	0	0.870114	0	0
LOC101927924	101927924	broad.mit.edu	37	2	130681236	130681236	+	RNA	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:130681236C>T	ENST00000450840.1	+	0	105				AC079776.2_ENST00000433290.1_RNA																							CCCAGGTGATCCACGGTCTTC	0.617000													3	8					0	0	0.184627	0	0
NLRP5	126206	broad.mit.edu	37	19	56549390	56549390	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:56549390G>A	ENST00000390649.3	+	10	2615		c.e10-1			NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5							mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGTCTCTGCAGGCTGGATTGC	0.557000													13	21					0	0	0.435327	0	0
CIB4	130106	broad.mit.edu	37	2	26818053	26818053	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:26818053G>A	ENST00000288861.4	-	4	372	c.319C>T	c.(319-321)Cgc>Tgc	p.R107C	CIB4_ENST00000405346.3_5'UTR	NM_001029881.1	NP_001025052.1	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	107	EF-hand 2.						calcium ion binding	p.R107C(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCATAGATGCGAAAGGCATAC	0.527000													28	60					0	0	0.717897	0	0
CDH6	1004	broad.mit.edu	37	5	31294195	31294195	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:31294195G>A	ENST00000265071.2	+	3	620	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K	CDH6_ENST00000514738.1_Missense_Mutation_p.E64K	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	119	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GCTGGACAGGGAAGAAAAACC	0.453000													17	52					0	0	0.500413	0	0
SZT2	23334	broad.mit.edu	37	1	43893785	43893785	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:43893785C>T	ENST00000562955.1	+	26	3744	c.3744C>T	c.(3742-3744)gtC>gtT	p.V1248V	SZT2_ENST00000372442.1_Silent_p.V406V	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1305						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GGTGCTATGTCCGTGGTGAGC	0.642000													24	28					0	0	0.654019	0	0
MRPL9	65005	broad.mit.edu	37	1	151733936	151733936	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:151733936G>A	ENST00000368830.3	-	5	663	c.579C>T	c.(577-579)ttC>ttT	p.F193F	MRPL9_ENST00000368829.3_Intron|MRPL9_ENST00000467306.1_5'UTR	NM_031420.2	NP_113608.1	Q9BYD2	RM09_HUMAN	mitochondrial ribosomal protein L9	193					translation	mitochondrial ribosome	structural constituent of ribosome			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CATTCTTAAAGAAGTGGCGGG	0.483000													60	27					0	0	0.870114	0	0
AFF3	3899	broad.mit.edu	37	2	100210436	100210436	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:100210436G>A	ENST00000317233.4	-	14	1922	c.1687C>T	c.(1687-1689)Ccg>Tcg	p.P563S	AFF3_ENST00000409236.1_Missense_Mutation_p.P563S|AFF3_ENST00000356421.2_Missense_Mutation_p.P588S|AFF3_ENST00000409579.1_Missense_Mutation_p.P588S	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	563					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GCGGGTGGCGGGGCGGCTGCG	0.736000													25	30					0	0	0.667858	0	0
WDR31	114987	broad.mit.edu	37	9	116083795	116083795	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:116083795G>A	ENST00000374193.4	-	8	880	c.634C>T	c.(634-636)Ctc>Ttc	p.L212F	WDR31_ENST00000341761.4_Missense_Mutation_p.L211F|WDR31_ENST00000374195.3_Missense_Mutation_p.L87F|WDR31_ENST00000461942.1_5'UTR	NM_001012361.2|NM_145241.3	NP_001012361.1|NP_660284.1	Q8NA23	WDR31_HUMAN	WD repeat domain 31	212										NS(1)|large_intestine(1)|lung(2)|prostate(2)	6						GCCCACCTGAGGGTTTTATCT	0.478000													17	33					0	0	0.557998	0	0
VAX1	11023	broad.mit.edu	37	10	118891748	118891748	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr10:118891748G>A	ENST00000277905.2	-	4	777	c.533C>T	c.(532-534)tCc>tTc	p.S178F		NM_199131.2	NP_954582.1	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1	0						nucleus	sequence-specific DNA binding	p.S178Y(1)		endometrium(1)|large_intestine(1)|lung(8)|ovary(2)	12				all cancers(201;0.0108)		TCTGCCCCCGGAGTCCCCACG	0.522000													28	64					0	0	0.788014	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61299440	61299440	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr20:61299440C>T	ENST00000217159.1	+	9	1920	c.1715C>T	c.(1714-1716)tCa>tTa	p.S572L	SLCO4A1_ENST00000370507.1_Missense_Mutation_p.S572L|SLCO4A1_ENST00000470412.1_3'UTR	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	572					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			AAATGCACTTCAACTTGTCAG	0.473000											OREG0026115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	119					0	0	0.654019	0	0
ZNF407	55628	broad.mit.edu	37	18	72346708	72346708	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr18:72346708C>T	ENST00000299687.5	+	1	3733	c.3733C>T	c.(3733-3735)Ccc>Tcc	p.P1245S	ZNF407_ENST00000577538.1_Missense_Mutation_p.P1245S|ZNF407_ENST00000582337.1_Missense_Mutation_p.P1245S|ZNF407_ENST00000309902.6_Missense_Mutation_p.P1245S	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGGTGTTGTCCCCCACAGACA	0.542000													13	42					0	0	0.479597	0	0
ZFX	7543	broad.mit.edu	37	X	24229336	24229336	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chrX:24229336A>G	ENST00000379177.1	+	11	2688	c.2261A>G	c.(2260-2262)tAt>tGt	p.Y754C	ZFX_ENST00000304543.5_Missense_Mutation_p.Y754C|ZFX_ENST00000338565.3_Missense_Mutation_p.Y704C|ZFX_ENST00000379188.3_Missense_Mutation_p.Y754C|ZFX_ENST00000540034.1_Missense_Mutation_p.Y793C|ZFX_ENST00000539115.1_Missense_Mutation_p.Y525C	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	754					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						TACTGTGAGTATAGCACTACA	0.443000													42	25					0	0	0.847076	0	0
AMPD1	270	broad.mit.edu	37	1	115226943	115226943	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:115226943G>A	ENST00000369538.3	-	4	558	c.511C>T	c.(511-513)Cgg>Tgg	p.R171W	AMPD1_ENST00000520113.2_Missense_Mutation_p.R175W|AMPD1_ENST00000353928.6_Missense_Mutation_p.R142W	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	142					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	CATAGTGCCCGATACAGACCT	0.413000													4	27					0	0	0.217242	0	0
PLK1	5347	broad.mit.edu	37	16	23700914	23700914	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:23700914C>T	ENST00000300093.4	+	9	1636	c.1525C>T	c.(1525-1527)Ccc>Tcc	p.P509S		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	509					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		CGCCCGGCTGCCCTACCTACG	0.592000													5	29					0	0	0.184627	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401347	77401347	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:77401347G>A	ENST00000282849.5	-	4	1187	c.769C>T	c.(769-771)Cgc>Tgc	p.R257C		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	257					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CATTTCTTGCGTCGTCCACAA	0.443000													19	35					0	0	0.575678	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092590	30092590	+	RNA	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr18:30092590G>A	ENST00000567636.1	+	0	965					NR_003558.1																						CTATCCTGAGGACGTGGATCA	0.468000													20	36					0	0	0.624587	0	0
CYP19A1	1588	broad.mit.edu	37	15	51507285	51507285	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr15:51507285C>T	ENST00000396402.1	-	8	1156	c.1003G>A	c.(1003-1005)Gaa>Aaa	p.E335K	CYP19A1_ENST00000396404.4_Missense_Mutation_p.E335K|CYP19A1_ENST00000260433.2_Missense_Mutation_p.E335K|RP11-108K3.1_ENST00000559909.1_lincRNA|CYP19A1_ENST00000559878.1_Missense_Mutation_p.E335K	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	335					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	GTCTGGATTTCCTTTATTATT	0.338000													6	8					0	0	0.217242	0	0
HELQ	113510	broad.mit.edu	37	4	84375049	84375049	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:84375049T>C	ENST00000295488.3	-	2	509	c.347A>G	c.(346-348)gAa>gGa	p.E116G	HELQ_ENST00000440639.2_5'UTR|HELQ_ENST00000510985.1_Missense_Mutation_p.E116G	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	116							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						AAAGGAGTTTTCAGTAAAGCT	0.373000								Other identified genes with known or suspected DNA repair function					65	138					0	0	0.870114	0	0
TRMT10A	93587	broad.mit.edu	37	4	100475031	100475031	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:100475031G>A	ENST00000273962.3	-	6	868	c.556C>T	c.(556-558)Ctt>Ttt	p.L186F	TRMT10A_ENST00000394876.2_Missense_Mutation_p.L186F|TRMT10A_ENST00000394877.3_Missense_Mutation_p.L186F	NM_152292.4	NP_689505.1			tRNA methyltransferase 10 homolog A (S. cerevisiae)																		TCTGACGTAAGGTAAATCAGG	0.348000													22	44					0	0	0.639603	0	0
VIT	5212	broad.mit.edu	37	2	36970354	36970354	+	Translation_Start_Site	SNP	A	A	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:36970354A>T	ENST00000497382.1	+	0	417				VIT_ENST00000379241.3_Missense_Mutation_p.D77V|VIT_ENST00000379242.3_Missense_Mutation_p.D77V|VIT_ENST00000401530.1_Missense_Mutation_p.D77V|VIT_ENST00000389975.3_Missense_Mutation_p.D77V|VIT_ENST00000457137.2_Missense_Mutation_p.D77V|VIT_ENST00000404084.1_Missense_Mutation_p.D55V			Q6UXI7	VITRN_HUMAN	vitrin							proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				TATGGCACTGACGTGTATGCA	0.478000													19	45					0	0	0.639603	0	0
CDH6	1004	broad.mit.edu	37	5	31323076	31323076	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:31323076G>A	ENST00000265071.2	+	12	2299	c.2034G>A	c.(2032-2034)agG>agA	p.R678R		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	678					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GCACCCTGAGGAATCCTGAAG	0.507000													12	36					0	0	0.387290	0	0
OR1C1	26188	broad.mit.edu	37	1	247921190	247921190	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:247921190G>A	ENST00000408896.2	-	1	792	c.519C>T	c.(517-519)atC>atT	p.I173I		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AATGATGGATGATATTGGAGG	0.473000													43	24					0	0	0.834066	0	0
RASSF9	9182	broad.mit.edu	37	12	86199698	86199698	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:86199698C>T	ENST00000361228.3	-	2	458	c.90G>A	c.(88-90)gtG>gtA	p.V30V		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	30	Ras-associating.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AAACCCAAACCACAATTTCCT	0.428000													11	43					0	0	0.435327	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455191	187455191	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:187455191C>T	ENST00000307161.5	-	2	906	c.705G>A	c.(703-705)agG>agA	p.R235R	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	235					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TGACAAAATTCCTGAAGTCCT	0.502000													38	97					0	0	0.827153	0	0
TMCO4	255104	broad.mit.edu	37	1	20107099	20107099	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:20107099G>A	ENST00000294543.6	-	4	394	c.153C>T	c.(151-153)tcC>tcT	p.S51S	TMCO4_ENST00000375127.1_Silent_p.S51S|TMCO4_ENST00000375122.2_Silent_p.S51S	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	51						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		GAAATAACTGGGACAGGGAGA	0.597000													15	29					0	0	0.539581	0	0
ZFP42	132625	broad.mit.edu	37	4	188924222	188924222	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:188924222A>T	ENST00000326866.4	+	4	669	c.261A>T	c.(259-261)gaA>gaT	p.E87D	ZFP42_ENST00000509524.1_Missense_Mutation_p.E87D	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	87					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		CCATCCTGGAAGAGGACTCAC	0.458000													16	46					0	0	0.539581	0	0
C1orf94	84970	broad.mit.edu	37	1	34666393	34666393	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:34666393G>A	ENST00000488417.1	+	3	1150	c.1030G>A	c.(1030-1032)Gag>Aag	p.E344K	C1orf94_ENST00000373374.3_Missense_Mutation_p.E154K	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	154							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				TGGCACCAAGGAGCCAAAAAA	0.562000													4	63					0	0	0.184627	0	0
TENM2	57451	broad.mit.edu	37	5	167674680	167674680	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:167674680T>A	ENST00000519204.1	+	26	6491	c.6373T>A	c.(6373-6375)Ttg>Atg	p.L2125M	TENM2_ENST00000520394.1_Missense_Mutation_p.L2007M|TENM2_ENST00000403607.2_Missense_Mutation_p.L2070M|TENM2_ENST00000545108.1_Missense_Mutation_p.L2245M|TENM2_ENST00000518659.1_Missense_Mutation_p.L2246M					teneurin transmembrane protein 2																		CCTCATGCCCTTGCGCTATGA	0.557000													13	25					0	0	0.435327	0	0
NLRC3	197358	broad.mit.edu	37	16	3613701	3613701	+	RNA	SNP	A	A	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr16:3613701A>C	ENST00000301749.7	-	0	1642				NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TAAAACACGTATTTCTTCTTG	0.607000													17	11					0	0	0.500413	0	0
OR1J4	26219	broad.mit.edu	37	9	125281684	125281684	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:125281684G>A	ENST00000340750.1	+	1	265	c.265G>A	c.(265-267)Gat>Aat	p.D89N		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						GCAAACTCAGGATCAATCCAT	0.413000													50	108					0	0	0.870114	0	0
RASGRF2	5924	broad.mit.edu	37	5	80390675	80390675	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:80390675C>T	ENST00000265080.4	+	12	1686	c.1618_splice	c.e12-1	p.S540_splice		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	540	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TGTGTTCAAGCTAAAGGTTCT	0.418000													10	40					0	0	0.411799	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110493686	110493686	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr8:110493686G>A	ENST00000378402.5	+	56	9456	c.9352G>A	c.(9352-9354)Gaa>Aaa	p.E3118K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3118	G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CGGTGGCTGGGAAGATAACCC	0.378000										HNSCC(38;0.096)			7	10					0	0	0.335167	0	0
TLE2	7089	broad.mit.edu	37	19	3011090	3011090	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:3011090G>A	ENST00000447365.2	-	8	1158	c.68C>T	c.(67-69)cCc>cTc	p.P23L	TLE2_ENST00000586422.1_Intron|TLE2_ENST00000455444.2_Silent_p.T192T|TLE2_ENST00000590536.1_Silent_p.T315T|TLE2_ENST00000426948.2_Silent_p.T328T|TLE2_ENST00000591529.1_Silent_p.T328T|TLE2_ENST00000262953.6_Silent_p.T314T|TLE2_ENST00000443826.3_Silent_p.T192T			Q04725	TLE2_HUMAN	transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)	142	Gln-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGCCCGGGGGTGGAAGCGT	0.647000													13	12					0	0	0.435327	0	0
IDO1	3620	broad.mit.edu	37	8	39782806	39782806	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr8:39782806G>A	ENST00000518237.1	+	9	1411	c.772G>A	c.(772-774)Gag>Aag	p.E258K	IDO1_ENST00000522495.1_Missense_Mutation_p.E258K|RP11-44K6.3_ENST00000517623.1_RNA	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	258					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	AGACCCAAAGGAGTTTGCAGG	0.502000													8	29					0	0	0.335167	0	0
DNAH5	1767	broad.mit.edu	37	5	13737604	13737604	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:13737604C>T	ENST00000265104.4	-	66	11316	c.11211_splice	c.e66-1	p.E3738_splice		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3738	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTCTCCAATTCCTATTAATTT	0.358000									Kartagener syndrome				8	15					0	0	0.335167	0	0
BLMH	642	broad.mit.edu	37	17	28613904	28613904	+	Silent	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:28613904G>A	ENST00000261714.6	-	5	654	c.480C>T	c.(478-480)atC>atT	p.I160I	BLMH_ENST00000394819.3_Silent_p.I73I	NM_000386.3	NP_000377.1	Q13867	BLMH_HUMAN	bleomycin hydrolase	160					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|stomach(1)	13						ATTTCTTAGGGATAACACCAT	0.338000													6	27					0	0	0.217242	0	0
ERMARD	55780	broad.mit.edu	37	6	170176106	170176106	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr6:170176106C>T	ENST00000588451.1	+	14	1570	c.1057C>T	c.(1057-1059)Cat>Tat	p.H353Y	C6orf70_ENST00000418781.3_Missense_Mutation_p.H489Y|C6orf70_ENST00000366772.2_Missense_Mutation_p.H489Y|C6orf70_ENST00000366773.3_Missense_Mutation_p.H489Y|C6orf70_ENST00000392095.4_Missense_Mutation_p.H363Y			Q5T6L9	CF070_HUMAN		489						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		GCTGTATCACCATATGCCTGA	0.378000													10	32					0	0	0.335167	0	0
RAF1	5894	broad.mit.edu	37	3	12653553	12653553	+	Silent	SNP	C	C	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:12653553C>A	ENST00000251849.4	-	3	655	c.216G>T	c.(214-216)gtG>gtT	p.V72V	RAF1_ENST00000442415.2_Silent_p.V72V|RAF1_ENST00000542177.1_Intron	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	72	RBD.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	TTCCATTTCGCACATTGACCT	0.498000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				32	71					2.61193e-14	2.70131e-14	0.740014	1	0
SNORD113-4	767564	broad.mit.edu	37	14	101402892	101402892	+	RNA	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr14:101402892C>T	ENST00000364802.1	+	0	65					NR_003232.1																						ATATGCAATTCTGAGGTCCAT	0.378000													21	34					0	0	0.681144	0	0
EHMT1	79813	broad.mit.edu	37	9	140648681	140648681	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:140648681C>T	ENST00000460843.1	+	8	1334	c.1307C>T	c.(1306-1308)cCc>cTc	p.P436L	EHMT1_ENST00000334856.6_Missense_Mutation_p.P405L|EHMT1_ENST00000462484.1_Missense_Mutation_p.P436L|EHMT1_ENST00000371394.2_3'UTR	NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	436					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		ACCGACAGTCCCTGGATCAAG	0.537000													24	60					0	0	0.639603	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176128	140176128	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:140176128G>A	ENST00000526136.1	+	1	1579	c.1579G>A	c.(1579-1581)Gaa>Aaa	p.E527K	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.E527K|PCDHA2_ENST00000378132.1_Missense_Mutation_p.E527K	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCACGAGGAAGTGGAGCT	0.687000													22	60					0	0	0.693898	0	0
NADK2	133686	broad.mit.edu	37	5	36225643	36225643	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr5:36225643C>T	ENST00000397338.1	-	4	293		c.e4+1		NADK2_ENST00000506945.1_Splice_Site|NADK2_ENST00000282512.3_Splice_Site|NADK2_ENST00000381937.4_Splice_Site|NADK2_ENST00000514504.1_Splice_Site					NAD kinase 2, mitochondrial																		TTCTTTCTTACCGTTCTGGAT	0.368000													15	41					0	0	0.520397	0	0
GPC5	2262	broad.mit.edu	37	13	92345605	92345605	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr13:92345605A>G	ENST00000377067.3	+	3	862	c.490A>G	c.(490-492)Aac>Gac	p.N164D		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	164						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AGAATTTGTAAACAGATTTTT	0.463000													28	82					0	0	0.706142	0	0
COL4A4	1286	broad.mit.edu	37	2	227914823	227914823	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:227914823G>C	ENST00000396625.3	-	34	3382	c.3175C>G	c.(3175-3177)Cct>Gct	p.P1059A	COL4A4_ENST00000329662.7_Missense_Mutation_p.P1059A	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1059	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GAAAATCCAGGGGGACCTGGA	0.423000													32	58					0	0	0.804634	0	0
CSN3	1448	broad.mit.edu	37	4	71114847	71114847	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr4:71114847C>T	ENST00000304954.3	+	4	306	c.220C>T	c.(220-222)Cca>Tca	p.P74S		NM_005212.2	NP_005203.2	P07498	CASK_HUMAN	casein kappa	74						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						AATTAATAATCCATATGTGCC	0.433000													22	25					0	0	0.592651	0	0
LEPRE1	64175	broad.mit.edu	37	1	43220884	43220884	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:43220884G>A	ENST00000236040.4	-	7	1215	c.1175C>T	c.(1174-1176)tCa>tTa	p.S392L	LEPRE1_ENST00000296388.5_Missense_Mutation_p.S392L|LEPRE1_ENST00000397054.3_Missense_Mutation_p.S392L	NM_001243246.1	NP_001230175.1	Q32P28	P3H1_HUMAN	leucine proline-enriched proteoglycan (leprecan) 1	392					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			large_intestine(2)|lung(15)|ovary(5)|prostate(1)|urinary_tract(3)	26	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGGAGTCCATGAATCCTAAGT	0.418000													16	20					0	0	0.520397	0	0
FGF23	8074	broad.mit.edu	37	12	4479645	4479645	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr12:4479645G>A	ENST00000237837.1	-	3	765	c.620C>T	c.(619-621)tCa>tTa	p.S207L		NM_020638.2	NP_065689.1	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23	207					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	22			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			GAGCTCCTGTGAACAGGAGGC	0.721000													12	12					0	0	0.457914	0	0
TOP2A	7153	broad.mit.edu	37	17	38556559	38556559	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr17:38556559A>G	ENST00000423485.1	-	23	3060	c.2902T>C	c.(2902-2904)Ttt>Ctt	p.F968L		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	968					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTCACAACAAATTTCACAGTG	0.413000													17	69					0	0	0.557998	0	0
ECT2	1894	broad.mit.edu	37	3	172472443	172472443	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:172472443T>A	ENST00000417960.1	+	3	600	c.123T>A	c.(121-123)taT>taA	p.Y41*	ECT2_ENST00000540509.1_Nonsense_Mutation_p.Y41*|ECT2_ENST00000441497.2_Nonsense_Mutation_p.Y41*|ECT2_ENST00000232458.5_Nonsense_Mutation_p.Y41*|ECT2_ENST00000392692.3_Nonsense_Mutation_p.Y41*|ECT2_ENST00000427830.1_Nonsense_Mutation_p.Y41*	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	41					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CTACTTCATATGTAGAAGGTA	0.313000													7	13					0	0	0.307466	0	0
FCER1A	2205	broad.mit.edu	37	1	159277691	159277691	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:159277691C>T	ENST00000368115.1	+	6	842	c.743C>T	c.(742-744)cCa>cTa	p.P248L	FCER1A_ENST00000368114.1_Missense_Mutation_p.P215L	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	248						integral to plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CTTCTGAACCCACATCCTAAG	0.383000													42	19					0	0	0.870114	0	0
THSD7B	80731	broad.mit.edu	37	2	138208522	138208522	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:138208522C>T	ENST00000409968.1	+	15	3245	c.3067C>T	c.(3067-3069)Cga>Tga	p.R1023*	THSD7B_ENST00000272643.3_Nonsense_Mutation_p.R1023*|THSD7B_ENST00000413152.2_Nonsense_Mutation_p.R992*|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B									p.R1023*(1)		NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGTGAGAATTCGATCCAAATG	0.408000													13	22					0	0	0.457914	0	0
SCN11A	11280	broad.mit.edu	37	3	38938697	38938697	+	Missense_Mutation	SNP	G	G	A	rs146174311		TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:38938697G>A	ENST00000302328.3	-	14	2240	c.2042C>T	c.(2041-2043)gCc>gTc	p.A681V	SCN11A_ENST00000444237.2_Missense_Mutation_p.A681V|SCN11A_ENST00000456224.3_Missense_Mutation_p.A681V|SCN11A_ENST00000450244.1_Missense_Mutation_p.A681V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	681					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.A681V(1)		NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCAGGATTTGGCTAACTTGAA	0.413000													17	20					0	0	0.608945	0	0
CD33	945	broad.mit.edu	37	19	51729081	51729081	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr19:51729081C>T	ENST00000436584.2	+	2	115	c.60C>T	c.(58-60)atC>atT	p.I20I	CD33_ENST00000262262.4_Silent_p.I147I|CD33_ENST00000391796.3_Silent_p.I147I|CD33_ENST00000421133.2_Silent_p.I20I			P20138	CD33_HUMAN	CD33 molecule	147	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GGCCCAAAATCCTCATCCCTG	0.572000													24	71					0	0	0.681144	0	0
RP11-640M9.2	0	broad.mit.edu	37	1	144598691	144598691	+	RNA	SNP	C	C	T	rs149760427		TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr1:144598691C>T	ENST00000419820.1	+	0	619																											GTGGACTCTCCGAGGTACTGA	0.577000													4	23					0	0	0.150653	0	0
XRN1	54464	broad.mit.edu	37	3	142031492	142031492	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:142031492G>A	ENST00000264951.4	-	41	4883	c.4766C>T	c.(4765-4767)cCc>cTc	p.P1589L	XRN1_ENST00000392981.2_Missense_Mutation_p.P1577L	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1589					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						CCCAGCCATGGGCATGGTCCC	0.443000													40	75					0	0	0.819951	0	0
CAMKV	79012	broad.mit.edu	37	3	49899546	49899546	+	Silent	SNP	C	C	T			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:49899546C>T	ENST00000477224.1	-	3	637	c.159G>A	c.(157-159)aaG>aaA	p.K53K	CAMKV_ENST00000463537.1_Silent_p.K53K|CAMKV_ENST00000498324.1_5'UTR|CAMKV_ENST00000296471.7_Silent_p.K53K|CAMKV_ENST00000467248.1_5'UTR|CAMKV_ENST00000488336.1_Silent_p.K53K|CAMKV_ENST00000466940.1_Silent_p.K53K			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	53	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TCTGGAACTTCTTGCAGGTGT	0.587000													16	24					0	0	0.539581	0	0
ARID1B	57492	broad.mit.edu	37	6	157469765	157469765	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr6:157469765C>G	ENST00000346085.5	+	9	2560	c.2559C>G	c.(2557-2559)taC>taG	p.Y853*	ARID1B_ENST00000350026.5_Nonsense_Mutation_p.Y840*|ARID1B_ENST00000275248.4_Nonsense_Mutation_p.Y782*|ARID1B_ENST00000367148.1_Nonsense_Mutation_p.Y840*	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	840					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TAGGTAACTACTCCAGACCCC	0.478000													20	38					0	0	0.592651	0	0
RALGDS	5900	broad.mit.edu	37	9	135975748	135975748	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:135975748G>A	ENST00000393160.3	-	17	2664	c.2311C>T	c.(2311-2313)Ccg>Tcg	p.P771S	RALGDS_ENST00000372062.3_Missense_Mutation_p.P797S|RALGDS_ENST00000372050.3_Missense_Mutation_p.P826S|RALGDS_ENST00000542690.1_Missense_Mutation_p.P897S|RALGDS_ENST00000372047.3_Missense_Mutation_p.P814S|RALGDS_ENST00000393157.3_Missense_Mutation_p.P825S|RALGDS_ENST00000469972.1_5'UTR	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	826					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		ATTACAGCCGGAGCCTTATCT	0.602000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								93	119					0	0	0.870114	0	0
BCL11A	53335	broad.mit.edu	37	2	60689253	60689254	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:60689253_60689254insG	ENST00000335712.6	-	4	1020_1021	c.793_794insC	c.(793-795)gttfs	p.V265fs	BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000538214.1_Frame_Shift_Ins_p.V231fs|BCL11A_ENST00000358510.4_Frame_Shift_Ins_p.V231fs|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000356842.4_Frame_Shift_Ins_p.V265fs	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	265	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGGACTAAACAGGGGGGGAGTG	0.584			T	IGH@	B-CLL								7	742	---	---	---	---					
NIFK-AS1	254128	broad.mit.edu	37	2	122466739	122466739	+	RNA	DEL	G	G	-	rs6733674	by1000genomes	TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr2:122466739delG	ENST00000419902.1	+	0	637					NR_037857.1																						tttttttgttgtttttttttt	0.458													3	4	---	---	---	---					
EDEM1	9695	broad.mit.edu	37	3	5248941	5248941	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr3:5248941delT	ENST00000256497.4	+	7	1454	c.1321delT	c.(1321-1323)ttfs	p.F442fs	EDEM1_ENST00000445686.1_Frame_Shift_Del_p.F247fs	NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	442					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TCTGCAGGCCTTTTTCCCTGG	0.463													7	193	---	---	---	---					
PPP1R18	170954	broad.mit.edu	37	6	30653494	30653496	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr6:30653494_30653496delTGC	ENST00000274853.3	-	1	2176_2178	c.300_302delGCA	c.(298-303)caa>ca	p.QQ102del	PPP1R18_ENST00000488324.1_Intron|PPP1R18_ENST00000399199.3_In_Frame_Del_p.QQ102del	NM_133471.3	NP_597728.1	Q6NYC8	PHTNS_HUMAN	protein phosphatase 1, regulatory subunit 18	102	Poly-Gln.					cytoplasm|cytoskeleton	actin binding	p.Q100Q(1)									CCGTtgttgttgctgctgctgct	0.650													7	133	---	---	---	---					
PRRC2B	84726	broad.mit.edu	37	9	134350033	134350034	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chr9:134350033_134350034insGC	ENST00000357304.4	+	15	2572_2573	c.2517_2518insGC	c.(2515-2520)gacaggfs	p.DR839fs	PRRC2B_ENST00000458550.1_Intron|PRRC2B_ENST00000405995.1_Intron|PRRC2B_ENST00000372249.1_5'UTR	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	839							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						ATGTTCAGGATGCAGGTGCTCC	0.500													7	27	---	---	---	---					
RNA5-8SP6	100873336	broad.mit.edu	37	Y	10037863	10037863	+	RNA	DEL	C	C	-			TCGA-FS-A1ZT-06A-11D-A197-08	TCGA-FS-A1ZT-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aebbb5e9-9014-45fa-87e0-3a67d9f01a7c	4040c106-4f6d-4fde-ae73-f591f01ccb2f	g.chrY:10037863delC	ENST00000515896.1	+	0	100																											ATCGACACTTCGAACGCACTT	0.552													3	6	---	---	---	---