Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RARS	5917	broad.mit.edu	37	5	167943887	167943887	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr5:167943887C>T	ENST00000231572.3	+	13	1611	c.1557C>T	c.(1555-1557)tcC>tcT	p.S519S	RARS_ENST00000538719.1_Silent_p.S313S	NM_002887.3	NP_002878.2	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	519					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|stomach(1)	22	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		ACATCTTCTCCTTTGACAAAA	0.413000													71	99					0	0	0.000147903	0	0
CNGA4	1262	broad.mit.edu	37	11	6263033	6263033	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr11:6263033C>T	ENST00000533426.1	+	5	748	c.597C>T	c.(595-597)tcC>tcT	p.S199S	CNGA4_ENST00000379936.2_Intron			Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	0					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTATTTGTTCCAGGGACAAGG	0.522000													18	41					0	0	5.01169e-05	0	0
COL23A1	91522	broad.mit.edu	37	5	177683870	177683870	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr5:177683870C>T	ENST00000390654.3	-	14	1191	c.834G>A	c.(832-834)ccG>ccA	p.P278P	COL23A1_ENST00000407622.1_Silent_p.P242P	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	278	Collagen-like 2.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		ATGTCACCTTCGGTCCTGGGG	0.632000													7	10					0	0	5.18039e-06	0	0
FOSB	2354	broad.mit.edu	37	19	45974075	45974075	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:45974075C>T	ENST00000353609.3	+	2	907	c.315C>T	c.(313-315)tcC>tcT	p.S105S	FOSB_ENST00000592811.1_Silent_p.S56S|FOSB_ENST00000592436.1_Silent_p.S105S|ERCC1_ENST00000423698.2_Intron|FOSB_ENST00000417353.2_Silent_p.S105S|FOSB_ENST00000591858.1_Silent_p.S66S|FOSB_ENST00000443841.2_Intron|FOSB_ENST00000585836.1_Silent_p.S66S|FOSB_ENST00000586615.1_Silent_p.S56S|FOSB_ENST00000590335.1_Silent_p.S105S	NM_006732.2	NP_006723.2	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	105					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	13		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		CCAGCTACTCCACACCAGGCA	0.682000													53	99					0	0	0.000147903	0	0
ADAM7	8756	broad.mit.edu	37	8	24358349	24358349	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr8:24358349C>T	ENST00000175238.6	+	19	2132	c.2049C>T	c.(2047-2049)atC>atT	p.I683I	RP11-624C23.1_ENST00000519689.1_RNA|RP11-561E1.1_ENST00000519364.1_RNA|ADAM7_ENST00000520720.1_Silent_p.I455I|ADAM7_ENST00000380789.1_Silent_p.I683I|RP11-624C23.1_ENST00000523578.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	683					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTGTCGGTATCGGAGTTCTTA	0.383000													24	18					0	0	9.22233e-05	0	0
CDC27	996	broad.mit.edu	37	17	45234323	45234323	+	Silent	SNP	T	T	C			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr17:45234323T>C	ENST00000066544.3	-	7	891	c.798A>G	c.(796-798)cgA>cgG	p.R266R	CDC27_ENST00000446365.2_Silent_p.R205R|CDC27_ENST00000527547.1_Silent_p.R266R|CDC27_ENST00000531206.1_Silent_p.R266R	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	266					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						CTAATAAACTTCGACCAGTTT	0.358000													6	63					0	0	8.12818e-05	0	0
MYOM2	9172	broad.mit.edu	37	8	2021526	2021526	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr8:2021526C>A	ENST00000262113.4	+	10	1207	c.1066C>A	c.(1066-1068)Cgc>Agc	p.R356S	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	356	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GTACACCCTGCGCATCGTGTC	0.617000													20	12					4.35082e-09	4.00184e-07	1.64113e-05	1	0
LRP1B	53353	broad.mit.edu	37	2	141201982	141201982	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:141201982G>A	ENST00000389484.3	-	65	11182	c.10211C>T	c.(10210-10212)aCc>aTc	p.T3404I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3404	LDL-receptor class A 23.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGTTCTTGGTACATTTGAA	0.383000										TSP Lung(27;0.18)			17	41					0	0	3.45872e-05	0	0
IGHV4-34	28395	broad.mit.edu	37	14	106829984	106829984	+	RNA	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr14:106829984G>A	ENST00000390616.2	-	0	92																											CTCACATCTGGGAGCTGCCAC	0.537000													17	19					0	0	7.07596e-05	0	0
SEMA5B	54437	broad.mit.edu	37	3	122629053	122629053	+	Silent	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr3:122629053G>A	ENST00000357599.3	-	23	3779	c.3393C>T	c.(3391-3393)ccC>ccT	p.P1131P	SEMA5B_ENST00000195173.4_3'UTR|SEMA5B_ENST00000451055.2_Silent_p.P1185P	NM_001031702.3|NM_001256348.1	NP_001026872.2|NP_001243277.1	Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	1131					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GTTTGTTCAGGGGGCTTGGGT	0.542000													27	57					0	0	0.000117367	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3674962	3674962	+	Silent	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr20:3674962G>A	ENST00000344754.4	-	12	3161	c.3162C>T	c.(3160-3162)atC>atT	p.I1054I	SIGLEC1_ENST00000202578.4_Silent_p.I1054I	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1054	Ig-like C2-type 10.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						TAGCCCCGTGGATCTCCAGAC	0.627000													51	86					0	0	0.000147903	0	0
MBNL3	55796	broad.mit.edu	37	X	131573585	131573585	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chrX:131573585C>A	ENST00000370857.3	-	1	120	c.55G>T	c.(55-57)Gtc>Ttc	p.V19F	MBNL3_ENST00000370853.3_Missense_Mutation_p.V19F|MBNL3_ENST00000370844.1_5'UTR|MBNL3_ENST00000370839.3_Missense_Mutation_p.V19F			Q9NUK0	MBNL3_HUMAN	muscleblind-like splicing regulator 3	19					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)	16	Acute lymphoblastic leukemia(192;0.000127)					TCTCTACAGACTTCTAAAGTC	0.428000													73	106					5.72486e-32	5.37772e-30	0.000147903	1	0
SF3B1	23451	broad.mit.edu	37	2	198267483	198267483	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:198267483C>T	ENST00000335508.5	-	14	1965	c.1874G>A	c.(1873-1875)cGt>cAt	p.R625H		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	625					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding	p.R625L(9)|p.R625P(2)|p.R625H(1)		NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTTGTGTTACGGACATACTC	0.438000			Mis		myelodysplastic syndrome								13	27					0	0	0.000151284	0	0
MTOR	2475	broad.mit.edu	37	1	11272938	11272938	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr1:11272938C>T	ENST00000361445.4	-	22	3389	c.3313G>A	c.(3313-3315)Gcc>Acc	p.A1105T		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1105					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity	p.A1105T(1)		breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TCCAGGTTGGCGCCAAACAGC	0.512000													23	52					0	0	5.49717e-05	0	0
ACAD10	80724	broad.mit.edu	37	12	112153653	112153653	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr12:112153653C>T	ENST00000455480.2	+	8	1149	c.972C>T	c.(970-972)caC>caT	p.H324H	ACAD10_ENST00000313698.4_Silent_p.H293H|ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000392636.2_5'UTR|ACAD10_ENST00000549590.1_Silent_p.H293H	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	293							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						AGTTTGATCACGGGCAGTCAA	0.473000													42	92					0	0	8.96297e-05	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540452	40540452	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:40540452G>A	ENST00000434248.1	-	5	2379	c.2314C>T	c.(2314-2316)Cag>Tag	p.Q772*	ZNF780B_ENST00000221355.6_Nonsense_Mutation_p.Q624*	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	772					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGAATACTCTGAGGTTGAACA	0.418000													25	26					0	0	9.22233e-05	0	0
CASKIN2	57513	broad.mit.edu	37	17	73497865	73497865	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr17:73497865C>T	ENST00000321617.3	-	18	3876	c.3290G>A	c.(3289-3291)gGa>gAa	p.G1097E	CASKIN2_ENST00000433559.2_Missense_Mutation_p.G1015E	NM_020753.3	NP_065804.2	Q8WXE0	CSKI2_HUMAN	CASK interacting protein 2	1097	Pro-rich.					cytoplasm				endometrium(1)|kidney(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTTACCTGCTCCGGGCACCTT	0.642000													48	73					0	0	0.000147903	0	0
CLEC14A	161198	broad.mit.edu	37	14	38723898	38723898	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr14:38723898C>T	ENST00000342213.2	-	1	1676	c.1330G>A	c.(1330-1332)Gag>Aag	p.E444K		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	444						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GGATCACTCTCCAGGCCCGGC	0.582000													25	24					0	0	4.16121e-05	0	0
TEX101	83639	broad.mit.edu	37	19	43922418	43922418	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:43922418G>A	ENST00000602198.1	+	8	1115	c.673G>A	c.(673-675)Gaa>Aaa	p.E225K	TEX101_ENST00000601707.1_3'UTR|TEX101_ENST00000253435.7_Missense_Mutation_p.E225K|TEX101_ENST00000598265.1_Missense_Mutation_p.E207K	NM_031451.4	NP_113639.4	Q9BY14	TX101_HUMAN	testis expressed 101	207						anchored to membrane|plasma membrane				large_intestine(1)|lung(12)|ovary(1)|skin(1)	15		Prostate(69;0.0199)				GTTTGTGAGGGAAGCGTGCCC	0.527000													40	58					0	0	5.1965e-05	0	0
BCAR1	9564	broad.mit.edu	37	16	75276399	75276399	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr16:75276399C>T	ENST00000546196.1	-	2	2167	c.515G>A	c.(514-516)cGc>cAc	p.R172H	BCAR1_ENST00000542031.2_Missense_Mutation_p.R199H|BCAR1_ENST00000538440.2_Missense_Mutation_p.R201H|BCAR1_ENST00000535626.2_Intron|BCAR1_ENST00000162330.5_Missense_Mutation_p.R201H|BCAR1_ENST00000420641.3_Missense_Mutation_p.R219H|BCAR1_ENST00000418647.3_Missense_Mutation_p.R247H|BCAR1_ENST00000393420.6_Missense_Mutation_p.R201H|BCAR1_ENST00000393422.2_Missense_Mutation_p.R219H			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	201	Substrate for kinases (By similarity).				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTCCCAGCTGCGTGTGTCCAT	0.637000													21	69					0	0	5.49717e-05	0	0
GNAQ	2776	broad.mit.edu	37	9	80409488	80409488	+	Missense_Mutation	SNP	T	T	G	rs121913492		TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr9:80409488T>G	ENST00000286548.4	-	5	848	c.626A>C	c.(625-627)cAa>cCa	p.Q209P	GNAQ_ENST00000397476.3_Missense_Mutation_p.Q7P	NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	209					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity	p.Q209L(87)|p.Q209P(64)|p.Q209Y(1)|p.Q209R(1)		NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						CTCTGACCTTTGGCCCCCTAC	0.348000			Mis		uveal melanoma								36	38					0	0	2.86225e-05	0	0
INPP5A	3632	broad.mit.edu	37	10	134594359	134594359	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr10:134594359A>G	ENST00000368594.3	+	14	1373	c.1096A>G	c.(1096-1098)Agc>Ggc	p.S366G		NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	366					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CCAGTCGGAGAGCGAGGAGAA	0.602000													4	95					0	0	1.23904e-05	0	0
AP3M2	10947	broad.mit.edu	37	8	42012386	42012386	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr8:42012386C>T	ENST00000518421.1	+	3	472	c.181C>T	c.(181-183)Cgc>Tgc	p.R61C	AP3M2_ENST00000520685.1_Intron|AP3M2_ENST00000396926.3_Missense_Mutation_p.R61C|AP3M2_ENST00000517922.1_Missense_Mutation_p.R61C|AP3M2_ENST00000174653.3_Missense_Mutation_p.R61C	NM_001134296.1	NP_001127768.1	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	61					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus				endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|prostate(1)|stomach(1)	17	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			AAGTGTTTACCGCCACAAGAT	0.483000													7	117					0	0	8.12818e-05	0	0
IPO13	9670	broad.mit.edu	37	1	44432250	44432250	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr1:44432250C>T	ENST00000372343.3	+	16	3063	c.2401C>T	c.(2401-2403)Ctg>Ttg	p.L801L	IPO13_ENST00000372339.3_Silent_p.L19L	NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	801					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CCTGCAGGCTCTGAAGCGGAA	0.607000													19	38					0	0	2.27731e-05	0	0
MDH2	4191	broad.mit.edu	37	7	75694157	75694157	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr7:75694157C>T	ENST00000315758.5	+	8	865	c.771C>T	c.(769-771)cgC>cgT	p.R257R	MDH2_ENST00000432020.2_Silent_p.R215R|MDH2_ENST00000443006.1_Silent_p.R150R	NM_005918.2	NP_005909.2	P40926	MDHM_HUMAN	malate dehydrogenase 2, NAD (mitochondrial)	257					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(2)	14					NADH(DB00157)	CCGGCGCCCGCTTTGTCTTCT	0.572000													19	31					0	0	0.000132079	0	0
MC5R	4161	broad.mit.edu	37	18	13826737	13826737	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr18:13826737G>A	ENST00000324750.3	+	1	1195	c.973G>A	c.(973-975)Gat>Aat	p.D325N		NM_005913.2	NP_005904.1	P33032	MC5R_HUMAN	melanocortin 5 receptor	325					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|upper_aerodigestive_tract(1)	41						TCCCAGAAGGGATTAAGCACA	0.522000													31	47					0	0	5.84002e-05	0	0
VAV1	7409	broad.mit.edu	37	19	6821684	6821684	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:6821684G>A	ENST00000304076.2	+	3	467	c.373G>A	c.(373-375)Ggg>Agg	p.G125R	VAV1_ENST00000539284.1_Missense_Mutation_p.G60R|VAV1_ENST00000602142.1_Missense_Mutation_p.G125R|VAV1_ENST00000596764.1_Missense_Mutation_p.G125R|VAV1_ENST00000599806.1_Missense_Mutation_p.G70R	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	125					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CCAGAACAGGGGGATCATGTG	0.642000													21	32					0	0	4.16121e-05	0	0
PPIL2	23759	broad.mit.edu	37	22	22049076	22049076	+	Silent	SNP	C	C	T	rs148599036		TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr22:22049076C>T	ENST00000406385.1	+	18	1362	c.1302C>T	c.(1300-1302)ttC>ttT	p.F434F	PPIL2_ENST00000412327.1_Silent_p.F434F|PPIL2_ENST00000456792.2_Silent_p.F413F|PPIL2_ENST00000398831.3_Silent_p.F434F|PPIL2_ENST00000335025.7_Silent_p.F434F|PPIL2_ENST00000492445.2_Silent_p.F434F			Q13356	PPIL2_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 2	434					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	17	Colorectal(54;0.105)					CTACAGTGTTCGTGGACCCCT	0.647000													17	42					0	0	7.07596e-05	0	0
GP9	2815	broad.mit.edu	37	3	128781018	128781018	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr3:128781018C>T	ENST00000307395.4	+	3	658	c.436C>T	c.(436-438)Ccg>Tcg	p.P146S		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	146					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	CTGGGTGCGCCCGGGGGTCTT	0.726000													6	4					0	0	5.18039e-06	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													7	85					0	0	5.18039e-06	0	0
GRB14	2888	broad.mit.edu	37	2	165383625	165383625	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:165383625C>T	ENST00000263915.3	-	4	1040	c.502G>A	c.(502-504)Gaa>Aaa	p.E168K	GRB14_ENST00000543549.1_Missense_Mutation_p.E81K	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	168	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						ATCACCAGTTCGTGGTCTTCT	0.264000													19	39					0	0	4.16121e-05	0	0
NPAP1	23742	broad.mit.edu	37	15	24924253	24924253	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr15:24924253G>A	ENST00000329468.2	+	1	3713	c.3239G>A	c.(3238-3240)gGa>gAa	p.G1080E		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCTGTATTTGGATATACTTCT	0.537000													49	55					0	0	0.000147903	0	0
AP1M1	8907	broad.mit.edu	37	19	16345235	16345235	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:16345235C>T	ENST00000291439.3	+	12	1710	c.1261C>T	c.(1261-1263)Cgg>Tgg	p.R421W	AP1M1_ENST00000590756.1_Missense_Mutation_p.R349W|AP1M1_ENST00000444449.2_Missense_Mutation_p.R433W|AP1M1_ENST00000541844.1_Missense_Mutation_p.R349W|AP1M1_ENST00000429941.2_Missense_Mutation_p.R368W	NM_032493.3	NP_115882.1	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	421	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|prostate(2)	21						TTACCAGCTCCGGACCCAGTG	0.687000													10	25					0	0	0.000151284	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41430339	41430339	+	RNA	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:41430339C>T	ENST00000599198.1	+	0	216					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TACTCAAATCCTTTCTGAGGG	0.562000													21	33					0	0	2.27731e-05	0	0
RARS	5917	broad.mit.edu	37	5	167943886	167943886	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr5:167943886C>T	ENST00000231572.3	+	13	1610	c.1556C>T	c.(1555-1557)tCc>tTc	p.S519F	RARS_ENST00000538719.1_Missense_Mutation_p.S313F	NM_002887.3	NP_002878.2	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	519					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(1)|stomach(1)	22	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		TACATCTTCTCCTTTGACAAA	0.413000													72	99					0	0	0.000147903	0	0
HHIP	64399	broad.mit.edu	37	4	145567871	145567871	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr4:145567871C>T	ENST00000296575.3	+	1	699	c.44C>T	c.(43-45)gCt>gTt	p.A15V	HHIP_ENST00000434550.2_Missense_Mutation_p.A15V|HHIP-AS1_ENST00000512359.1_RNA	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	15						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		CTGGCCGTGGCTCTGGGCTTC	0.617000											OREG0016346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	94					0	0	0.000147903	0	0
DCDC1	341019	broad.mit.edu	37	11	31086649	31086649	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr11:31086649C>T	ENST00000597505.1	-	17	2349	c.2350G>A	c.(2350-2352)Gat>Aat	p.D784N	DCDC1_ENST00000437348.1_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TGGGTCACATCTACTTGTGCA	0.438000													5	24					0	0	1.23904e-05	0	0
IGHV4-34	28395	broad.mit.edu	37	14	106829985	106829985	+	RNA	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr14:106829985G>A	ENST00000390616.2	-	0	91																											TCACATCTGGGAGCTGCCACC	0.532000													17	18					0	0	7.07596e-05	0	0
IL26	55801	broad.mit.edu	37	12	68595823	68595823	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr12:68595823G>A	ENST00000229134.4	-	4	468	c.404C>T	c.(403-405)aCc>aTc	p.T135I	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	135					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTTCATCCTGGTAATGGATTT	0.269000													7	12					0	0	1.12685e-05	0	0
CNTN6	27255	broad.mit.edu	37	3	1414548	1414548	+	Silent	SNP	G	G	A			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr3:1414548G>A	ENST00000446702.2	+	14	2322	c.1695G>A	c.(1693-1695)agG>agA	p.R565R	CNTN6_ENST00000539053.1_Silent_p.R493R|CNTN6_ENST00000350110.2_Silent_p.R565R			Q9UQ52	CNTN6_HUMAN	contactin 6	565	Ig-like C2-type 6.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TGATGATAAGGAATATTCAGT	0.373000													32	38					0	0	0.000109025	0	0
LIMCH1	22998	broad.mit.edu	37	4	41621233	41621233	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr4:41621233G>C	ENST00000313860.7	+	8	765	c.711G>C	c.(709-711)ttG>ttC	p.L237F	LIMCH1_ENST00000509638.1_Missense_Mutation_p.L78F|LIMCH1_ENST00000381753.4_Missense_Mutation_p.L83F|LIMCH1_ENST00000512632.1_Missense_Mutation_p.L237F|LIMCH1_ENST00000503057.1_Missense_Mutation_p.L78F|LIMCH1_ENST00000511496.1_Missense_Mutation_p.L78F|LIMCH1_ENST00000514096.1_Missense_Mutation_p.L90F|LIMCH1_ENST00000512820.1_Missense_Mutation_p.L237F|LIMCH1_ENST00000396595.3_Missense_Mutation_p.L83F|LIMCH1_ENST00000512946.1_Missense_Mutation_p.L237F|LIMCH1_ENST00000513024.1_Missense_Mutation_p.L78F|LIMCH1_ENST00000509277.1_Missense_Mutation_p.L83F|LIMCH1_ENST00000508501.1_Missense_Mutation_p.L237F|LIMCH1_ENST00000509454.1_Missense_Mutation_p.L85F	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	237					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						AATCCGACTTGCCTCATCGGA	0.507000													7	301					0	0	8.12818e-05	0	0
SLC12A7	10723	broad.mit.edu	37	5	1060464	1060464	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr5:1060464G>C	ENST00000264930.5	-	21	2885	c.2842C>G	c.(2842-2844)Cga>Gga	p.R948G		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	948					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CGTACCTCTCGCTCCTGCTCG	0.562000													36	230					0	0	0.000125731	0	0
AP1M1	8907	broad.mit.edu	37	19	16345234	16345234	+	Silent	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:16345234C>T	ENST00000291439.3	+	12	1709	c.1260C>T	c.(1258-1260)ctC>ctT	p.L420L	AP1M1_ENST00000590756.1_Silent_p.L348L|AP1M1_ENST00000444449.2_Silent_p.L432L|AP1M1_ENST00000541844.1_Silent_p.L348L|AP1M1_ENST00000429941.2_Silent_p.L367L	NM_032493.3	NP_115882.1	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	420	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|prostate(2)	21						ATTACCAGCTCCGGACCCAGT	0.687000													12	26					0	0	3.45872e-05	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15582857	15582857	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:15582857C>T	ENST00000292609.4	-	3	1316	c.1187G>A	c.(1186-1188)cGc>cAc	p.R396H	PGLYRP2_ENST00000340880.4_Missense_Mutation_p.R396H			Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2	396					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(2)|skin(3)|stomach(2)|urinary_tract(1)	28						CAGCTTCGGGCGGCCCCGATA	0.657000													14	17					0	0	7.07596e-05	0	0
DGKG	1608	broad.mit.edu	37	3	185970917	185970917	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr3:185970917C>T	ENST00000265022.3	-	18	2104	c.1565G>A	c.(1564-1566)gGa>gAa	p.G522E	DGKG_ENST00000382164.4_Missense_Mutation_p.G483E|DGKG_ENST00000344484.4_Missense_Mutation_p.G497E|DGKG_ENST00000544847.1_Missense_Mutation_p.G463E	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	522	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AAGGTCATTTCCTGTTCCAAG	0.517000													25	46					0	0	0.000147802	0	0
GIGYF2	26058	broad.mit.edu	37	2	233708909	233708910	+	In_Frame_Ins	INS	-	-	AGC			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr2:233708909_233708910insAGC	ENST00000373566.3	+	25	3306_3307	c.3109_3110insAGC	c.(3109-3111)gca>AGCgca	p.1036_1037insS	GIGYF2_ENST00000409480.1_In_Frame_Ins_p.1036_1037insS|GIGYF2_ENST00000409547.1_In_Frame_Ins_p.1014_1015insS|GIGYF2_ENST00000409451.3_In_Frame_Ins_p.1035_1036insS|GIGYF2_ENST00000409196.3_In_Frame_Ins_p.1008_1009insS|GIGYF2_ENST00000373563.4_In_Frame_Ins_p.1014_1015insS|GIGYF2_ENST00000452341.2_In_Frame_Ins_p.857_857S>KR			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1014					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCAAATGCAAAagcagcagcag	0.490													2	4	---	---	---	---					
NTN5	126147	broad.mit.edu	37	19	49173724	49173724	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ER-A2NF-06A-11D-A19A-08	TCGA-ER-A2NF-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	15daadb0-6b24-4248-9225-470dc08f1552	f0d22e58-5486-47c4-a316-e974e2bcbae6	g.chr19:49173724delG	ENST00000270235.4	-	2	615	c.520delC	c.(520-522)gcfs	p.R174fs	SEC1P_ENST00000430145.2_RNA	NM_145807.1	NP_665806.1	Q8WTR8	NET5_HUMAN	netrin 5	174	Laminin EGF-like 1.					extracellular region				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	10						CAGTGGCAGCGGGGGGGCCGG	0.766													2	4	---	---	---	---