Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CD163	9332	broad.mit.edu	37	12	7653993	7653993	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr12:7653993T>C	ENST00000359156.4	-	3	401	c.199A>G	c.(199-201)Aaa>Gaa	p.K67E	CD163_ENST00000396620.3_Missense_Mutation_p.K67E|CD163_ENST00000432237.2_Missense_Mutation_p.K67E|CD163_ENST00000541972.1_Missense_Mutation_p.K55E	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	67	SRCR 1.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						TCCTGGACTTTCACTTCCACT	0.498000													30	53					0	0	0.000339439	0	0
LRBA	987	broad.mit.edu	37	4	151773037	151773037	+	Splice_Site	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr4:151773037C>T	ENST00000535741.1	-	23	4298	c.3825_splice	c.e23+1	p.E1275_splice	LRBA_ENST00000507224.1_Splice_Site_p.E1275_splice|LRBA_ENST00000357115.3_Splice_Site_p.E1275_splice|LRBA_ENST00000510413.1_Splice_Site_p.E1275_splice			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1275						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ATAAAATCACCTCAAGCACAT	0.368000													13	17					0	0	0.00010058	0	0
CELP	1057	broad.mit.edu	37	9	135962226	135962226	+	RNA	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr9:135962226C>T	ENST00000411440.2	+	0	733					NR_001275.2																						CCCTACACTACGGAAAACAGC	0.607000													5	5					0	0	8.12818e-05	0	0
CEL	1056	broad.mit.edu	37	9	135946427	135946427	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr9:135946427C>T	ENST00000372080.4	+	11	1563	c.1547C>T	c.(1546-1548)aCg>aTg	p.T516M	CEL_ENST00000351304.7_Missense_Mutation_p.T447M	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	513					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CCCTACACTACGGAAAACAGC	0.607000													9	70					0	0	0.000151284	0	0
MYO7A	4647	broad.mit.edu	37	11	76867771	76867771	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:76867771G>C	ENST00000409709.3	+	6	808	c.536G>C	c.(535-537)aGt>aCt	p.S179T	MYO7A_ENST00000409893.1_Missense_Mutation_p.S179T|MYO7A_ENST00000458637.2_Missense_Mutation_p.S179T|MYO7A_ENST00000409619.2_Missense_Mutation_p.S168T	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	179	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCAGCCATCAGTGGGCAGCAC	0.627000													14	1317					0	0	6.40141e-05	0	0
PGK2	5232	broad.mit.edu	37	6	49754466	49754466	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr6:49754466A>T	ENST00000304801.3	-	1	587	c.435T>A	c.(433-435)gaT>gaA	p.D145E		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	145					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CTTCTATTTTATCTGGCTCAG	0.507000													41	50					0	0	0.000509022	0	0
DZIP3	9666	broad.mit.edu	37	3	108363492	108363492	+	Silent	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:108363492G>A	ENST00000361582.3	+	14	1853	c.1623G>A	c.(1621-1623)ggG>ggA	p.G541G	DZIP3_ENST00000463306.1_Silent_p.G541G	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	541					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TGCGCCTTGGGATGATGCAAG	0.408000													23	54					0	0	0.000229342	0	0
CREB3L2	64764	broad.mit.edu	37	7	137612996	137612996	+	Silent	SNP	C	C	T	rs146953741	byFrequency	TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr7:137612996C>T	ENST00000330387.6	-	2	570	c.219G>A	c.(217-219)ccG>ccA	p.P73P	CREB3L2_ENST00000456390.1_Silent_p.P73P|CREB3L2_ENST00000458726.1_Silent_p.P10P|CREB3L2_ENST00000452463.1_Silent_p.P73P	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	73					chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						TGAGAGGCGCCGGGGACGTCG	0.577000			T	FUS	fibromyxoid sarcoma								12	12					0	0	0.00010058	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555263	44555263	+	Silent	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr18:44555263G>A	ENST00000330682.2	-	1	1186	c.951C>T	c.(949-951)aaC>aaT	p.N317N	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	317	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						GCATCTTAGCGTTCACTCTGC	0.647000													25	2551					0	0	0.000442599	0	0
CRB1	23418	broad.mit.edu	37	1	197396945	197396945	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:197396945C>G	ENST00000367397.1	+	3	1491	c.633C>G	c.(631-633)atC>atG	p.I211M	CRB1_ENST00000544212.1_Missense_Mutation_p.I311M|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.I718M|CRB1_ENST00000367400.3_Missense_Mutation_p.I830M|CRB1_ENST00000535699.1_Missense_Mutation_p.I761M			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	830	EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GAGATGTCATCTACATTGGTG	0.373000													9	38					0	0	0.000274275	0	0
NDUFAF2	91942	broad.mit.edu	37	5	60369037	60369037	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:60369037G>A	ENST00000296597.5	+	2	340	c.213G>A	c.(211-213)tgG>tgA	p.W71*	NDUFAF2_ENST00000512623.1_3'UTR|NDUFAF2_ENST00000511107.1_Intron	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2	71						membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				CAACAGAATGGGAAGGTAAGT	0.318000													82	132					0	0	0.000147903	0	0
LIM2	3982	broad.mit.edu	37	19	51883857	51883857	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:51883857C>G	ENST00000221973.3	-	4	530	c.488G>C	c.(487-489)gGa>gCa	p.G163A	LIM2_ENST00000596399.1_Missense_Mutation_p.G121A	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	121					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		GACGGTGACTCCAGTGTAGAT	0.612000													16	38					0	0	0.000422831	0	0
GRIN3A	116443	broad.mit.edu	37	9	104499855	104499855	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr9:104499855T>C	ENST00000361820.3	-	1	1007	c.407A>G	c.(406-408)aAc>aGc	p.N136S		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	136					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TTCCACGCGGTTCAGGTTGTC	0.672000													3	10					0	0	1.23904e-05	0	0
DIS3	22894	broad.mit.edu	37	13	73350130	73350130	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr13:73350130C>G	ENST00000377767.4	-	5	855	c.755G>C	c.(754-756)aGa>aCa	p.R252T	DIS3_ENST00000545453.1_Missense_Mutation_p.R90T|DIS3_ENST00000377780.4_Missense_Mutation_p.R222T	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	252					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		CCTGCTAGCTCTAAATGTTCC	0.328000										Multiple Myeloma(4;0.011)			31	34					0	0	0.000409698	0	0
CPNE3	8895	broad.mit.edu	37	8	87563304	87563304	+	Silent	SNP	C	C	T	rs137984538	by1000genomes	TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr8:87563304C>T	ENST00000521271.1	+	13	1206	c.1044C>T	c.(1042-1044)ggC>ggT	p.G348G	CPNE3_ENST00000198765.4_Silent_p.G348G	NM_003909.3	NP_003900.1	O75131	CPNE3_HUMAN	copine III	348	VWFA.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	23						TTGGTTTTGGCGCTCAGATAC	0.363000													7	30					0	0	8.12818e-05	0	0
OR2A5	393046	broad.mit.edu	37	7	143747506	143747506	+	Missense_Mutation	SNP	T	T	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr7:143747506T>A	ENST00000408906.2	+	1	46	c.12T>A	c.(10-12)aaT>aaA	p.N4K		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					TGACAAAAAATCAGACATGGG	0.478000													17	65					0	0	0.000132079	0	0
FOLH1	2346	broad.mit.edu	37	11	49168493	49168493	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:49168493C>T	ENST00000340334.7	-	20	2391	c.2023G>A	c.(2023-2025)Gtc>Atc	p.V675I	FOLH1_ENST00000533034.1_Missense_Mutation_p.V644I|FOLH1_ENST00000256999.2_Missense_Mutation_p.V690I|FOLH1_ENST00000343844.4_Missense_Mutation_p.V382I|FOLH1_ENST00000356696.3_Missense_Mutation_p.V659I	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	690					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GCATAGATGACATGCCTGTTG	0.408000													15	75					0	0	0.000117367	0	0
AGO2	27161	broad.mit.edu	37	8	141557663	141557663	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr8:141557663T>C	ENST00000220592.5	-	13	1764	c.1652A>G	c.(1651-1653)aAc>aGc	p.N551S	AGO2_ENST00000519980.1_Missense_Mutation_p.N551S	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		CCTCTGCACGTTCTTCATCTG	0.622000													18	68					0	0	7.07596e-05	0	0
TXLNB	167838	broad.mit.edu	37	6	139591648	139591648	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr6:139591648C>T	ENST00000358430.3	-	4	864	c.632G>A	c.(631-633)cGa>cAa	p.R211Q		NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	211						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		CAATTTGCTTCGAGCGAGGAT	0.443000													23	36					0	0	0.000586117	0	0
CTDSPL2	51496	broad.mit.edu	37	15	44751268	44751268	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr15:44751268G>A	ENST00000260327.4	+	2	619	c.56G>A	c.(55-57)cGc>cAc	p.R19H	CTDSPL2_ENST00000558373.1_Missense_Mutation_p.R19H|CTDSPL2_ENST00000558966.1_Missense_Mutation_p.R19H|CTDSPL2_ENST00000396780.1_Missense_Mutation_p.R19H	NM_016396.2	NP_057480.2	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	19							phosphoprotein phosphatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	13		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		CAAACACAACGCACTGCCAGA	0.403000													31	42					0	0	0.000339439	0	0
AP2M1	1173	broad.mit.edu	37	3	183898715	183898715	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:183898715C>T	ENST00000382456.3	+	5	816	c.502C>T	c.(502-504)Cgg>Tgg	p.R168W	AP2M1_ENST00000411763.2_Missense_Mutation_p.R195W|EIF2B5_ENST00000444495.1_Intron|AP2M1_ENST00000439647.1_Missense_Mutation_p.R168W|AP2M1_ENST00000292807.5_Missense_Mutation_p.R170W|AP2M1_ENST00000461733.1_3'UTR	NM_001025205.1	NP_001020376.1	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	170	MHD.				axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity			endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	18	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CAAGTATCGTCGGAATGAGCT	0.552000													34	70					0	0	0.000159656	0	0
FRG1B	284802	broad.mit.edu	37	20	29632633	29632633	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr20:29632633G>C	ENST00000278882.3	+	8	828	c.448G>C	c.(448-450)Gac>Cac	p.D150H	FRG1B_ENST00000358464.4_Missense_Mutation_p.D150H																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAGCTTCCAAGACCACAAACT	0.299000													9	767					0	0	0.000151284	0	0
NLRP3	114548	broad.mit.edu	37	1	247593035	247593035	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:247593035G>A	ENST00000366497.2	+	5	3085	c.2305G>A	c.(2305-2307)Ggc>Agc	p.G769S	NLRP3_ENST00000348069.2_Intron|NLRP3_ENST00000391828.3_Missense_Mutation_p.G769S|NLRP3_ENST00000391827.2_Intron|NLRP3_ENST00000336119.3_Missense_Mutation_p.G769S|NLRP3_ENST00000366496.2_Missense_Mutation_p.G769S	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	826					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CCAGCATCCTGGCTGTAACAT	0.498000													12	40					0	0	0.000219431	0	0
LPA	4018	broad.mit.edu	37	6	160969513	160969513	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr6:160969513G>A	ENST00000447678.1	-	32	5272	c.5152C>T	c.(5152-5154)Caa>Taa	p.Q1718*	LPA_ENST00000316300.5_Nonsense_Mutation_p.Q1718*	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4226	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TTCTTACCTTGTTCAGAAGGA	0.512000													11	26					0	0	0.00010058	0	0
PPAP2C	8612	broad.mit.edu	37	19	287703	287703	+	Missense_Mutation	SNP	G	G	A	rs61745392	byFrequency	TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:287703G>A	ENST00000269812.3	-	3	302	c.253C>T	c.(253-255)Cgc>Tgc	p.R85C	PPAP2C_ENST00000434325.2_Missense_Mutation_p.R29C|PPAP2C_ENST00000327790.3_Missense_Mutation_p.R106C	NM_003712.2|NM_177526.1	NP_003703.1|NP_803545.1	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C	85					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(1)|lung(1)|skin(1)	5		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGTCCGAGCGAGAATAGAGC	0.622000													88	137					0	0	0.000147903	0	0
PITPNM1	9600	broad.mit.edu	37	11	67266200	67266200	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:67266200C>G	ENST00000356404.3	-	10	1576	c.1351G>C	c.(1351-1353)Gcg>Ccg	p.A451P	PITPNM1_ENST00000534749.1_Missense_Mutation_p.A451P|PITPNM1_ENST00000436757.2_Missense_Mutation_p.A451P	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	451					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						TGCACATCCGCCTGCTTGGAG	0.667000													29	363					0	0	0.000339439	0	0
ODF3	113746	broad.mit.edu	37	11	197726	197726	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:197726G>A	ENST00000325113.4	+	3	592	c.275G>A	c.(274-276)cGc>cAc	p.R92H	BET1L_ENST00000410108.1_Intron|ODF3_ENST00000342593.5_Missense_Mutation_p.R92H|ODF3_ENST00000525282.1_Missense_Mutation_p.R92H	NM_053280.3	NP_444510.2	Q96PU9	ODF3A_HUMAN	outer dense fiber of sperm tails 3	92					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm				biliary_tract(1)|breast(1)|kidney(1)|large_intestine(2)|ovary(1)|prostate(2)|skin(1)	9		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.95e-27)|Epithelial(43;2.66e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.55e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		ATCCTGGGGCGCTACCAAACC	0.622000													16	24					0	0	0.000175454	0	0
DOCK7	85440	broad.mit.edu	37	1	62958387	62958387	+	Silent	SNP	A	A	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:62958387A>T	ENST00000251157.5	-	41	5355	c.5322T>A	c.(5320-5322)gcT>gcA	p.A1774A	DOCK7_ENST00000340370.5_Silent_p.A1752A	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1783	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TAGAGAAGGAAGCAGCTGCTT	0.408000													38	77					0	0	0.000374591	0	0
ANK3	288	broad.mit.edu	37	10	62023637	62023637	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr10:62023637C>T	ENST00000280772.1	-	6	846	c.655G>A	c.(655-657)Gcc>Acc	p.A219T	ANK3_ENST00000503366.1_Missense_Mutation_p.A202T|ANK3_ENST00000373827.2_Missense_Mutation_p.A213T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	219					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGCAGCAGGGCGGCGGCTTTC	0.547000													13	27					0	0	0.000566183	0	0
MARCKSL1	65108	broad.mit.edu	37	1	32800473	32800473	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr1:32800473A>G	ENST00000329421.7	-	2	658	c.313T>C	c.(313-315)Ttc>Ctc	p.F105L		NM_023009.6	NP_075385.1	P49006	MRP_HUMAN	MARCKS-like 1	105						plasma membrane	calmodulin binding			breast(1)|large_intestine(3)|lung(1)|ovary(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TTTCTCTTGAAGGACAGGCCG	0.582000													15	80					0	0	0.000308642	0	0
CCDC81	60494	broad.mit.edu	37	11	86131054	86131054	+	Silent	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:86131054G>A	ENST00000278487.3	+	13	2060	c.981G>A	c.(979-981)gcG>gcA	p.A327A	CCDC81_ENST00000354755.1_Silent_p.A502A|CCDC81_ENST00000445632.2_Silent_p.A592A|CCDC81_ENST00000528728.1_Silent_p.A327A			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	592										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				GGAGTGCTGCGATGAAGAAGC	0.512000													89	1647					0	0	0.000589545	0	0
JOSD2	126119	broad.mit.edu	37	19	51013582	51013582	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:51013582T>G	ENST00000598418.1	-	2	360	c.107A>C	c.(106-108)cAg>cCg	p.Q36P	JOSD2_ENST00000595669.1_Missense_Mutation_p.Q36P|JOSD2_ENST00000391815.3_Missense_Mutation_p.Q36P|JOSD2_ENST00000601423.1_Missense_Mutation_p.Q36P	NM_001270639.1|NM_001270640.1	NP_001257568.1|NP_001257569.1	Q8TAC2	JOS2_HUMAN	Josephin domain containing 2	36	Josephin.				protein deubiquitination		ubiquitin-specific protease activity			kidney(1)|lung(3)|prostate(1)	5		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0364)		GCTAAAGAGCTGCTGCTGCAG	0.662000													16	62					0	0	0.000566183	0	0
ZNF423	23090	broad.mit.edu	37	16	49672281	49672281	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr16:49672281T>C	ENST00000561648.1	-	4	835	c.782A>G	c.(781-783)gAc>gGc	p.D261G	ZNF423_ENST00000535559.1_Missense_Mutation_p.D144G|ZNF423_ENST00000262383.2_Missense_Mutation_p.D261G|ZNF423_ENST00000563137.2_Missense_Mutation_p.D201G|ZNF423_ENST00000562520.1_Missense_Mutation_p.D201G|ZNF423_ENST00000562871.1_Missense_Mutation_p.D201G|ZNF423_ENST00000567169.1_Missense_Mutation_p.D144G	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	261					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CATGAAGTCGTCCTTCTTGGC	0.607000													9	19					0	0	0.000274275	0	0
CDHR2	54825	broad.mit.edu	37	5	176005428	176005428	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:176005428T>C	ENST00000510636.1	+	16	1911	c.1637T>C	c.(1636-1638)cTg>cCg	p.L546P	CDHR2_ENST00000261944.5_Missense_Mutation_p.L546P|CDHR2_ENST00000506348.1_Missense_Mutation_p.L546P	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	546	Cadherin 5.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GGTGAGCTGCTGGACCGGGAG	0.622000													4	24					0	0	1.23904e-05	0	0
MYH14	79784	broad.mit.edu	37	19	50735328	50735328	+	Splice_Site	SNP	G	G	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:50735328G>C	ENST00000440075.2	+	10	1161		c.e10+1		MYH14_ENST00000376970.2_Splice_Site|MYH14_ENST00000598205.1_Splice_Site|MYH14_ENST00000596571.1_Splice_Site|MYH14_ENST00000262269.8_Splice_Site|MYH14_ENST00000425460.1_Splice_Site|MYH14_ENST00000601313.1_Splice_Site			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle						axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GAAATCATCTGTGAGTGAGCC	0.622000													9	26					0	0	3.86212e-05	0	0
LCN15	389812	broad.mit.edu	37	9	139658430	139658430	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr9:139658430G>T	ENST00000316144.5	-	2	152	c.128C>A	c.(127-129)gCa>gAa	p.A43E	LCN15_ENST00000482511.1_5'UTR	NM_203347.1	NP_976222.1	Q6UWW0	LCN15_HUMAN	lipocalin 15	43					lipid metabolic process	extracellular region	binding|transporter activity			endometrium(1)|lung(1)	2						GCAGTCAGATGCCATGGAGAC	0.657000													13	59					0.00010058	0.00468116	0.00010058	1	0
EVPL	2125	broad.mit.edu	37	17	74005670	74005670	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr17:74005670T>C	ENST00000301607.3	-	22	3869	c.3616A>G	c.(3616-3618)Aca>Gca	p.T1206A	EVPL_ENST00000586740.1_Missense_Mutation_p.T1228A	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1206	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						TCCTGCTCTGTCTCCGGATCC	0.622000													11	122					0	0	3.86212e-05	0	0
OVCH2	341277	broad.mit.edu	37	11	7721843	7721843	+	RNA	SNP	C	C	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:7721843C>G	ENST00000454689.1	-	0	900				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GCTTAGTTACCAGTTTGGATG	0.488000													13	18					0	0	7.07596e-05	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554431	140554431	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:140554431G>A	ENST00000231137.3	+	1	2189	c.2015G>A	c.(2014-2016)cGg>cAg	p.R672Q		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		672					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTACCTGCGGCTCCCGGAG	0.692000													8	55					0	0	0.000274275	0	0
PLSCR4	57088	broad.mit.edu	37	3	145917809	145917809	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:145917809T>C	ENST00000354952.2	-	6	655	c.415A>G	c.(415-417)Act>Gct	p.T139A	PLSCR4_ENST00000383083.2_Intron|PLSCR4_ENST00000493382.1_Missense_Mutation_p.T139A|PLSCR4_ENST00000433593.2_Intron|PLSCR4_ENST00000446574.2_Missense_Mutation_p.T139A	NM_020353.2	NP_065086.2	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4	139					blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			kidney(1)|large_intestine(6)|lung(9)|urinary_tract(1)	17						CTATTATTAGTTTCAAAACAT	0.323000													11	8					0	0	6.40141e-05	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240627	39240627	+	Missense_Mutation	SNP	T	T	C	rs139671425	by1000genomes	TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr17:39240627T>C	ENST00000391417.4	+	1	169	c.169T>C	c.(169-171)Tct>Cct	p.S57P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.S57P(4)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						GTGCTGCCAGTCTGTGTGCTG	0.667000													5	31					0	0	8.12818e-05	0	0
LARP6	55323	broad.mit.edu	37	15	71124798	71124798	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr15:71124798C>T	ENST00000299213.8	-	3	1139	c.1069G>A	c.(1069-1071)Gcc>Acc	p.A357T		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	357					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						TTGTTGGTGGCCGCGTGCCGT	0.607000													6	66					0	0	8.12818e-05	0	0
SLC17A4	10050	broad.mit.edu	37	6	25770658	25770658	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr6:25770658C>A	ENST00000377905.4	+	5	697	c.578C>A	c.(577-579)cCc>cAc	p.P193H	SLC17A4_ENST00000439485.2_Intron|SLC17A4_ENST00000397076.2_Intron	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	193					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						AAATGGGCTCCCCCACTGGAA	0.458000													21	132					7.41877e-09	3.65593e-07	0.000229342	1	0
ZNF512	84450	broad.mit.edu	37	2	27826170	27826170	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr2:27826170G>A	ENST00000355467.4	+	9	1015	c.932G>A	c.(931-933)gGg>gAg	p.G311E	RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000556601.1_Missense_Mutation_p.G180E|ZNF512_ENST00000416005.2_Missense_Mutation_p.G282E|ZNF512_ENST00000413371.2_Missense_Mutation_p.G234E|ZNF512_ENST00000379717.1_Missense_Mutation_p.G310E			Q96ME7	ZN512_HUMAN	zinc finger protein 512	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					TCAGAGCATGGGCCTGTGAGT	0.493000													21	82					0	0	0.000147802	0	0
TECTA	7007	broad.mit.edu	37	11	120996244	120996244	+	Silent	SNP	G	G	A	rs140634094		TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:120996244G>A	ENST00000392793.1	+	8	1708	c.1437G>A	c.(1435-1437)ccG>ccA	p.P479P	TECTA_ENST00000264037.2_Silent_p.P479P			O75443	TECTA_HUMAN	tectorin alpha	479	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix		p.P479P(1)	TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ATGGCAGGCCGGCCATGTCTG	0.577000													31	44					0	0	0.000279167	0	0
RELN	5649	broad.mit.edu	37	7	103290823	103290823	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr7:103290823G>A	ENST00000428762.1	-	16	2059	c.1900C>T	c.(1900-1902)Cga>Tga	p.R634*	RELN_ENST00000424685.2_Nonsense_Mutation_p.R634*|RELN_ENST00000343529.5_Nonsense_Mutation_p.R634*	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	634					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATTGTTATTCGGTTCCACCTG	0.413000													7	77					0	0	8.12818e-05	0	0
TUBB6	84617	broad.mit.edu	37	18	12308734	12308734	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr18:12308734T>C	ENST00000317702.5	+	2	340	c.106T>C	c.(106-108)Tac>Cac	p.Y36H	TUBB6_ENST00000586653.1_Missense_Mutation_p.Y36H|TUBB6_ENST00000590967.1_Missense_Mutation_p.Y36H|TUBB6_ENST00000591909.1_Missense_Mutation_p.Y36H|TUBB6_ENST00000592683.1_Missense_Mutation_p.Y36H|TUBB6_ENST00000591208.1_Missense_Mutation_p.Y36H			Q9BUF5	TBB6_HUMAN	tubulin, beta 6 class V	36					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)	14				READ - Rectum adenocarcinoma(1;0.0649)		GGCCGGAGGCTACGTGGGAGA	0.652000													15	73					0	0	9.7654e-05	0	0
EEFSEC	60678	broad.mit.edu	37	3	127965854	127965854	+	Silent	SNP	C	C	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:127965854C>A	ENST00000254730.6	+	2	546	c.492C>A	c.(490-492)acC>acA	p.T164T	EEFSEC_ENST00000483457.1_Silent_p.T164T	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	164						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						ATAAAATGACCAAGAAAATGC	0.463000													7	136					0.000157383	0.00722454	0.000157383	1	0
PLCH1	23007	broad.mit.edu	37	3	155199621	155199621	+	Silent	SNP	G	G	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:155199621G>A	ENST00000460012.1	-	23	4461	c.4104C>T	c.(4102-4104)aaC>aaT	p.N1368N	PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000414191.1_Silent_p.N1368N|PLCH1_ENST00000494598.1_Intron|PLCH1_ENST00000334686.6_Silent_p.N1368N|PLCH1_ENST00000340059.7_Silent_p.N1406N			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1406					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TACAGTAGCCGTTTCTCAAAC	0.413000													39	18					0	0	0.000589545	0	0
DDX10	1662	broad.mit.edu	37	11	108712205	108712205	+	Splice_Site	SNP	T	T	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:108712205T>C	ENST00000526794.1	+	15	2279		c.e15+2		DDX10_ENST00000322536.3_Splice_Site			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10								ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		AAGCATCGGGTAAGCTTTCCA	0.308000			T	NUP98	AML*								13	15					0	0	0.000308642	0	0
NLRP2	55655	broad.mit.edu	37	19	55495050	55495050	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr19:55495050C>A	ENST00000543010.1	+	6	2127	c.1984C>A	c.(1984-1986)Ctc>Atc	p.L662I	NLRP2_ENST00000448584.2_Missense_Mutation_p.L662I|NLRP2_ENST00000538819.1_Missense_Mutation_p.L638I|NLRP2_ENST00000339757.7_Missense_Mutation_p.L640I|NLRP2_ENST00000537859.1_Missense_Mutation_p.L640I|NLRP2_ENST00000263437.6_Missense_Mutation_p.L659I|NLRP2_ENST00000391721.4_Missense_Mutation_p.L638I|NLRP2_ENST00000427260.2_Missense_Mutation_p.L639I	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	662					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AAAGGAGAATCTCCCGGAGAA	0.493000													8	22					1.06961e-07	5.1946e-06	0.000157383	1	0
MYO5A	4644	broad.mit.edu	37	15	52697566	52697566	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr15:52697566C>G	ENST00000399231.3	-	9	1214	c.971G>C	c.(970-972)gGa>gCa	p.G324A	MYO5A_ENST00000399233.2_Missense_Mutation_p.G324A|MYO5A_ENST00000358212.6_Missense_Mutation_p.G324A|MYO5A_ENST00000553916.1_Missense_Mutation_p.G324A|MYO5A_ENST00000356338.6_Missense_Mutation_p.G324A	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	324	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TCGGAAAATTCCCATTTGATG	0.368000													51	297					0	0	0.000147903	0	0
BRIP1	83990	broad.mit.edu	37	17	59871040	59871040	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr17:59871040G>C	ENST00000259008.2	-	10	1658	c.1391C>G	c.(1390-1392)gCt>gGt	p.A464G	BRIP1_ENST00000577598.1_Missense_Mutation_p.A464G	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	464					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						TATTTTACAAGCTGATTCATA	0.333000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					8	18					0	0	0.000157383	0	0
DPPA2	151871	broad.mit.edu	37	3	109033385	109033385	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr3:109033385G>C	ENST00000478945.1	-	2	251	c.5C>G	c.(4-6)tCa>tGa	p.S2*		NM_138815.3	NP_620170.3	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	2						nucleus	nucleic acid binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						ATTTGCATCTGACATTTTCAG	0.378000													16	14					0	0	0.000132079	0	0
MLLT4	4301	broad.mit.edu	37	6	168281157	168281157	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr6:168281157G>T	ENST00000366806.2	+	6	999	c.857G>T	c.(856-858)gGt>gTt	p.G286V	MLLT4_ENST00000392108.3_Missense_Mutation_p.G286V|MLLT4_ENST00000351017.4_Missense_Mutation_p.G286V|MLLT4_ENST00000400822.3_Missense_Mutation_p.G285V|MLLT4_ENST00000392112.1_Missense_Mutation_p.G285V|MLLT4_ENST00000344191.4_Missense_Mutation_p.G286V|MLLT4_ENST00000447894.2_Missense_Mutation_p.G286V			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	286	Ras-associating 2.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GAGAAGTATGGTCTGGAAAAA	0.383000			T	MLL	AL								45	108					5.73435e-26	2.86803e-24	0.000147903	1	0
TMPRSS3	64699	broad.mit.edu	37	21	43802280	43802280	+	Silent	SNP	G	G	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr21:43802280G>T	ENST00000291532.3	-	9	1801	c.846C>A	c.(844-846)gcC>gcA	p.A282A	TMPRSS3_ENST00000398397.3_Silent_p.A282A|TMPRSS3_ENST00000398405.1_Silent_p.A280A|TMPRSS3_ENST00000433957.2_Silent_p.A282A|TMPRSS3_ENST00000474596.1_5'UTR|TMPRSS3_ENST00000380399.1_Silent_p.A366A	NM_032404.2	NP_115780.1	P57727	TMPS3_HUMAN	transmembrane protease, serine 3	282	Peptidase S1.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						AGTGGGATGGGGCTGGATTGT	0.527000													18	57					5.35267e-07	2.5624e-05	9.7654e-05	1	0
CXorf67	340602	broad.mit.edu	37	X	51151051	51151051	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chrX:51151051C>G	ENST00000342995.2	+	1	1285	c.1183C>G	c.(1183-1185)Cgt>Ggt	p.R395G						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						GGTCCCAAGCCGTGCTTCCCC	0.587000													5	18					0	0	1.23904e-05	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47592647	47592647	+	Silent	SNP	C	C	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr20:47592647C>T	ENST00000371917.4	+	14	1869	c.1869C>T	c.(1867-1869)tcC>tcT	p.S623S		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	623					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			CCACAGTGTCCTCGGGGACCC	0.537000													8	36					0	0	0.000274275	0	0
ACOXL	55289	broad.mit.edu	37	2	111789223	111789224	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr2:111789223_111789224insT	ENST00000389811.4	+	16	1615_1616	c.1391_1392insT	c.(1390-1392)gttfs	p.V464fs	ACOXL_ENST00000439055.1_Frame_Shift_Ins_p.V434fs			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	464					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						AAGAAGGAGGATTTTTTCCATG	0.450													16	76	---	---	---	---					
MCC	4163	broad.mit.edu	37	5	112824048	112824049	+	In_Frame_Ins	INS	-	-	GCC	rs35336557		TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr5:112824048_112824049insGCC	ENST00000408903.3	-	1	478_479	c.63_64insGGC	c.(61-66)gggcgg>ggGGCgcgg	p.21_22GR>GAR		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	549					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ctgctgccgctgccgccgccgc	0.738													6	7	---	---	---	---					
PPFIBP2	8495	broad.mit.edu	37	11	7672899	7672899	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:7672899delC	ENST00000299492.4	+	23	2648	c.2260delC	c.(2260-2262)gcfs	p.R754fs	PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000530181.1_Frame_Shift_Del_p.R611fs|PPFIBP2_ENST00000528883.1_Frame_Shift_Del_p.R642fs|PPFIBP2_ENST00000533792.1_Frame_Shift_Del_p.R596fs	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	754	SAM 3.			R -> L (in Ref. 4; AAC26104).	cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding	p.R754C(1)		breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CCTGGAGCCACGCTTCACTGG	0.572													26	41	---	---	---	---					
TSKU	25987	broad.mit.edu	37	11	76506673	76506675	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr11:76506673_76506675delCTG	ENST00000527881.1	+	2	1039_1041	c.13_15delCTG	c.(13-15)del	p.L9del	TSKU_ENST00000333090.4_In_Frame_Del_p.L9del			Q8WUA8	TSK_HUMAN	tsukushi, small leucine rich proteoglycan	9						extracellular region				NS(1)|large_intestine(4)|lung(6)|urinary_tract(1)	12	Ovarian(111;0.112)					GCCGTGGCCCCTGCTGCTGCTGC	0.616													10	204	---	---	---	---					
HERC1	8925	broad.mit.edu	37	15	63970383	63970384	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr15:63970383_63970384insT	ENST00000443617.2	-	37	6817_6818	c.6730_6731insA	c.(6730-6732)taafs	p.*2244fs	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2244					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						ACATATCTTAATTTTGTGAAGC	0.436													8	78	---	---	---	---					
PLIN1	5346	broad.mit.edu	37	15	90209096	90209097	+	In_Frame_Ins	INS	-	-	CGG			TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chr15:90209096_90209097insCGG	ENST00000300055.5	-	9	1451_1452	c.1286_1287insCCG	c.(1285-1287)cga>cCCGga	p.429_429R>PG	PLIN1_ENST00000430628.2_In_Frame_Ins_p.429_429R>PG	NM_002666.4	NP_002657.3	O60240	PLIN1_HUMAN	perilipin 1	429					triglyceride catabolic process	lipid particle	lipid binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(2)	13						GCTCCGCCTCCCGGCGCTCGAC	0.762													6	8	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-ER-A19T-06A-11D-A19A-08	TCGA-ER-A19T-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3f98d326-5676-4257-9af8-0a5f5d3c2527	e694c1a2-86f0-43d0-95cc-4cfaf0b04060	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			3	4	---	---	---	---