Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CYP3A5	1577	broad.mit.edu	37	7	99272209	99272209	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:99272209C>T	ENST00000339843.2	-	3	635		c.e3-1		CYP3A5_ENST00000343703.5_Splice_Site|CYP3A5_ENST00000480723.1_Splice_Site|CYP3A5_ENST00000222982.4_Splice_Site|CYP3A5_ENST00000439761.1_Splice_Site					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					TCCAGAGACCCTGGGAGAGGA	0.393000													11	31					0	0	1	0	0
FABP2	2169	broad.mit.edu	37	4	120243228	120243228	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr4:120243228G>A	ENST00000274024.3	-	1	317	c.30C>T	c.(28-30)gaC>gaT	p.D10D		NM_000134.3	NP_000125.2	P12104	FABPI_HUMAN	fatty acid binding protein 2, intestinal	10							fatty acid binding			breast(1)|large_intestine(4)|lung(1)|ovary(1)|pancreas(1)	8						TTTCACTCCGGTCTACCTTCC	0.383000													33	28					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5436188	5436188	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:5436188C>T	ENST00000345221.3	-	11	3804	c.3250G>A	c.(3250-3252)Ggg>Agg	p.G1084R	NLRP1_ENST00000262467.5_Missense_Mutation_p.G1088R|NLRP1_ENST00000354411.3_Missense_Mutation_p.G1054R|NLRP1_ENST00000572272.1_Missense_Mutation_p.G1084R|NLRP1_ENST00000577119.1_Missense_Mutation_p.G1054R|NLRP1_ENST00000269280.4_Missense_Mutation_p.G1084R|NLRP1_ENST00000571307.1_5'UTR	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	1084					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GCCACAGGCCCCGTGGGGCCC	0.607000													10	18					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516083	140516083	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:140516083C>A	ENST00000231134.5	+	1	1284	c.1067C>A	c.(1066-1068)cCa>cAa	p.P356Q		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		356	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCCCTACCCCAGAAAATGCC	0.527000													25	24					7.07758e-08	7.22619e-08	1	1	0
CYP21A1P	1590	broad.mit.edu	37	6	31975458	31975458	+	RNA	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:31975458G>A	ENST00000342991.6	+	0	1381					NR_040090.1		Q5ST44	Q5ST44_HUMAN									electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										ATTCAGCAGCGACTGTAGGAG	0.652000													12	28					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245862241	245862241	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:245862241G>A	ENST00000366518.4	+	11	5041	c.4937G>A	c.(4936-4938)aGg>aAg	p.R1646K	KIF26B_ENST00000407071.2_Missense_Mutation_p.R2027K			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	2027					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CGCCAGCAGAGGATCGCCGAG	0.557000													13	24					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142573596	142573596	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:142573596G>A	ENST00000359396.3	-	7	1069	c.824C>T	c.(823-825)tCg>tTg	p.S275L	RP11-114L10.2_ENST00000438839.1_RNA	NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	275					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding	p.S275L(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					ATAGAGAGTCGAGGTCAGTGG	0.517000													39	70					0	0	1	0	0
SLC52A3	113278	broad.mit.edu	37	20	742420	742420	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:742420C>T	ENST00000381944.3	-	4	1363	c.1122G>A	c.(1120-1122)ggG>ggA	p.G374G	SLC52A3_ENST00000473664.1_5'UTR|SLC52A3_ENST00000217254.7_Silent_p.G374G			Q9NQ40	RFT2_HUMAN	solute carrier family 52 (riboflavin transporter), member 3	374					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity										TGTTGTAGCCCCCAAAGCAGG	0.632000													10	22					0	0	1	0	0
ARID3C	138715	broad.mit.edu	37	9	34622353	34622353	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:34622353G>A	ENST00000378909.2	-	5	1131	c.1039C>T	c.(1039-1041)Ccc>Tcc	p.P347S		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	347	Pro-rich.|REKLES.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CCCCTCAGGGGAACCTTGCCA	0.622000													11	12					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48162523	48162523	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:48162523C>T	ENST00000311303.3	-	9	1707	c.1362G>A	c.(1360-1362)aaG>aaA	p.K454K	ABCC12_ENST00000416054.1_Silent_p.K454K|ABCC12_ENST00000448542.1_Silent_p.K454K	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	454						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				TCTGCAATTTCTTTGGGGTAC	0.498000													20	35					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784887	82784887	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:82784887C>A	ENST00000423517.2	-	2	1407	c.1070G>T	c.(1069-1071)gGg>gTg	p.G357V	PCLO_ENST00000333891.8_Missense_Mutation_p.G357V	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	323	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTTTGTTGTCCCTGGTGGCTG	0.602000													3	26					0.004672	0.00469614	1	1	0
CYP4F24P	388514	broad.mit.edu	37	19	15880779	15880779	+	RNA	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:15880779C>T	ENST00000595525.1	+	0	529				CYP4F24P_ENST00000587443.2_RNA																							CAACACCTTCCCATCTTCATC	0.507000													4	18					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370128	126370128	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr4:126370128G>A	ENST00000394329.3	+	9	7970	c.7957G>A	c.(7957-7959)Gag>Aag	p.E2653K	FAT4_ENST00000335110.5_Missense_Mutation_p.E951K	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2653	Cadherin 25.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ctCCTCTTACGAGAAACTTGA	0.373000													16	11					0	0	1	0	0
MEMO1	51072	broad.mit.edu	37	2	32093518	32093518	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:32093518G>A	ENST00000295065.4	-	9	1115	c.806C>T	c.(805-807)tCg>tTg	p.S269L	MEMO1_ENST00000379383.3_Missense_Mutation_p.S272L|MEMO1_ENST00000490459.1_5'UTR|DPY30_ENST00000446765.1_5'UTR|MEMO1_ENST00000404530.1_Missense_Mutation_p.S269L|MEMO1_ENST00000426310.2_Missense_Mutation_p.S246L	NM_015955.2	NP_057039.1	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1	269					regulation of microtubule-based process	cytosol|nucleus				NS(1)|breast(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|skin(2)	17	Acute lymphoblastic leukemia(172;0.155)					ATTCAAAAACGAAAAACTCAT	0.423000													6	7					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34628623	34628623	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:34628623C>T	ENST00000354181.3	-	2	751	c.259G>A	c.(259-261)Gat>Aat	p.D87N	SLC12A6_ENST00000458406.2_Missense_Mutation_p.D28N|SLC12A6_ENST00000397702.2_Missense_Mutation_p.D28N|SLC12A6_ENST00000397707.2_Missense_Mutation_p.D87N|SLC12A6_ENST00000558589.1_Missense_Mutation_p.D78N|SLC12A6_ENST00000560611.1_Missense_Mutation_p.D87N|SLC12A6_ENST00000558667.1_Missense_Mutation_p.D87N			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	87					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	TCGATGACATCCTGGGGGTGA	0.498000													12	13					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47500851	47500851	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr18:47500851C>T	ENST00000285039.7	-	10	1490	c.1191G>A	c.(1189-1191)gtG>gtA	p.V397V		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	397	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GCGCATTGATCACCTGCTGCA	0.587000													24	53					0	0	1	0	0
TRAF6	7189	broad.mit.edu	37	11	36518747	36518747	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:36518747G>A	ENST00000526995.1	-	4	763	c.517C>T	c.(517-519)Cat>Tat	p.H173Y	TRAF6_ENST00000348124.5_Missense_Mutation_p.H173Y	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	173	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				ATATTAATATGGAATTTTTGG	0.368000													15	11					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72170599	72170599	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:72170599G>A	ENST00000537465.1	-	8	1196	c.1038C>T	c.(1036-1038)atC>atT	p.I346I	PMFBP1_ENST00000355636.6_Silent_p.I201I|PMFBP1_ENST00000237353.10_Silent_p.I346I			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	346										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TACCCTTCATGATGTTTCTCT	0.562000													11	18					0	0	1	0	0
KLK15	55554	broad.mit.edu	37	19	51331041	51331041	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:51331041C>T	ENST00000326856.4	-	3	200	c.71G>A	c.(70-72)gGt>gAt	p.G24D	KLK15_ENST00000596931.1_Missense_Mutation_p.G24D|KLK15_ENST00000416184.1_Missense_Mutation_p.G25D|KLK15_ENST00000598239.1_Missense_Mutation_p.G25D|KLK15_ENST00000301421.2_Missense_Mutation_p.G25D	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	25	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		ACACTCGTCACCTTCCAGCAA	0.582000													10	33					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18875090	18875090	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:18875090G>A	ENST00000406451.3	+	20	2608	c.2457_splice	c.e20-1	p.D820_splice	HDAC9_ENST00000401921.1_Splice_Site_p.D779_splice|HDAC9_ENST00000441542.2_Splice_Site_p.D823_splice|HDAC9_ENST00000432645.2_Splice_Site_p.D820_splice	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	820	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TTCCCTGTAGGATGTTCACCA	0.443000													5	13					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	153994657	153994657	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:153994657G>A	ENST00000496811.1	-	24	2800	c.2720C>T	c.(2719-2721)cCa>cTa	p.P907L	DHX36_ENST00000329463.5_Missense_Mutation_p.P893L|DHX36_ENST00000308361.6_Missense_Mutation_p.P878L|DHX36_ENST00000544526.1_Missense_Mutation_p.P893L	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	907						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GAGACAGTATGGGGAAACCTC	0.348000													7	21					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20226842	20226842	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:20226842G>A	ENST00000245957.5	+	19	2218	c.2142G>A	c.(2140-2142)agG>agA	p.R714R	C20orf26_ENST00000389656.3_Silent_p.R70R|C20orf26_ENST00000377309.2_Silent_p.R70R|C20orf26_ENST00000377293.1_Silent_p.R70R	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	714										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		CTGAACAAAGGAAATTTTTAG	0.343000													8	31					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183622485	183622485	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:183622485G>A	ENST00000264065.6	+	19	2291	c.1876G>A	c.(1876-1878)Gaa>Aaa	p.E626K		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	626	Thioredoxin 3.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTGTGCCCAGGAAAACGTTCA	0.333000													18	28					0	0	1	0	0
MSH5-SAPCD1	100532732	broad.mit.edu	37	6	31729911	31729911	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:31729911G>A	ENST00000493662.2	+	24	2449	c.2393G>A	c.(2392-2394)gGa>gAa	p.G798E	MSH5_ENST00000395853.1_Missense_Mutation_p.G455E|MSH5-SAPCD1_ENST00000491552.1_3'UTR|MSH5_ENST00000375740.3_Missense_Mutation_p.G769E|MSH5_ENST00000431848.2_Missense_Mutation_p.G480E|MSH5_ENST00000375703.3_Missense_Mutation_p.G782E|MSH5_ENST00000534153.4_Missense_Mutation_p.G798E|MSH5_ENST00000375742.3_Missense_Mutation_p.G798E|MSH5_ENST00000375750.3_Missense_Mutation_p.G781E|MSH5_ENST00000375755.3_Missense_Mutation_p.G781E																							ATCCGCAGTGGAAAACCCATC	0.488000													16	38					0	0	1	0	0
CEACAM8	1088	broad.mit.edu	37	19	43098946	43098946	+	Missense_Mutation	SNP	C	C	T	rs143763173		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:43098946C>T	ENST00000244336.5	-	1	136	c.35G>A	c.(34-36)cGc>cAc	p.R12H	LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA|CEACAM8_ENST00000599005.1_Missense_Mutation_p.R12H	NM_001816.3	NP_001807.2	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 8	12					immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				CCAGGGGATGCGCCATCTGCA	0.612000													4	135					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15793319	15793319	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:15793319G>A	ENST00000550308.1	+	6	1026	c.647_splice	c.e6+1	p.E216_splice	CYP4F12_ENST00000324632.9_Splice_Site_p.E216_splice	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					CCATTGTCAGGAGTGAGTTCC	0.498000													26	31					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75898207	75898207	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:75898207T>G	ENST00000322507.8	-	8	1177	c.868A>C	c.(868-870)Aca>Cca	p.T290P	COL12A1_ENST00000483888.2_Missense_Mutation_p.T290P|COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000416123.2_Missense_Mutation_p.T290P	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	290	VWFA 1.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AGTGAAGGTGTGGAGGCAATT	0.408000													23	50					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28991185	28991185	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr18:28991185C>T	ENST00000359747.4	+	14	2215	c.2186C>T	c.(2185-2187)cCc>cTc	p.P729L	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Intron|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	710					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAACATCCTCCCTTTTCAGAA	0.607000													16	32					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83823866	83823866	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:83823866C>T	ENST00000265362.3	-	1	351	c.37G>A	c.(37-39)Gga>Aga	p.G13R	SEMA3A_ENST00000436949.1_Missense_Mutation_p.G13R	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	13					axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						AGTAATACTCCCCAGAAAAGA	0.418000													43	83					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18622602	18622602	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr18:18622602G>A	ENST00000399799.1	-	7	1684	c.744C>T	c.(742-744)tcC>tcT	p.S248S		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	248	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					CACCACCTTGGGATTTTAATA	0.403000													35	50					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181690896	181690896	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:181690896C>T	ENST00000526775.1	+	16	2124	c.1959C>T	c.(1957-1959)atC>atT	p.I653I	CACNA1E_ENST00000357570.5_Silent_p.I604I|CACNA1E_ENST00000367573.2_Silent_p.I653I|CACNA1E_ENST00000367570.1_Silent_p.I653I|CACNA1E_ENST00000367567.4_Silent_p.I260I|CACNA1E_ENST00000358338.5_Silent_p.I604I|CACNA1E_ENST00000360108.3_Silent_p.I653I	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	653					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TTTTGTAGATCCTGACGGGTG	0.532000													30	35					0	0	1	0	0
C17orf47	284083	broad.mit.edu	37	17	56620078	56620078	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:56620078C>T	ENST00000321691.3	-	1	1651	c.1470G>A	c.(1468-1470)gaG>gaA	p.E490E	RP11-112H10.4_ENST00000580589.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580769.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	490										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AACTTGGAAACTCCTTTGGTG	0.468000													113	160					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43376041	43376041	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:43376041G>A	ENST00000244296.2	-	3	724	c.587C>T	c.(586-588)tCc>tTc	p.S196F	PSG1_ENST00000595124.1_Intron|PSG1_ENST00000595356.1_Missense_Mutation_p.S196F|PSG1_ENST00000312439.6_Missense_Mutation_p.S196F|PSG1_ENST00000403380.3_Intron|PSG1_ENST00000436291.2_Missense_Mutation_p.S196F	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				GTTGGTTTCGGACAGCTTCAA	0.522000													103	169					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107720083	107720083	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:107720083G>A	ENST00000388781.3	-	15	1933	c.1850C>T	c.(1849-1851)cCt>cTt	p.P617L	LAMB4_ENST00000414450.2_Missense_Mutation_p.P617L|LAMB4_ENST00000388780.3_Missense_Mutation_p.P617L|LAMB4_ENST00000205386.4_Missense_Mutation_p.P617L	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	617	Laminin IV type B.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						GAAGTCCACAGGAAAGGGAAT	0.473000													10	29					0	0	1	0	0
ZNF746	155061	broad.mit.edu	37	7	149172180	149172180	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:149172180G>A	ENST00000340622.3	-	7	1510	c.1230C>T	c.(1228-1230)gcC>gcT	p.A410A	ZNF746_ENST00000458143.2_Silent_p.A411A			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	410					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGTCCAAGATGGCCTCTCCGT	0.632000													7	6					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	121001176	121001176	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:121001176C>T	ENST00000273666.6	+	20	2445	c.2174C>T	c.(2173-2175)tCc>tTc	p.S725F	STXBP5L_ENST00000472879.1_Intron|STXBP5L_ENST00000497029.1_Missense_Mutation_p.S725F|STXBP5L_ENST00000471454.1_Intron|STXBP5L_ENST00000492541.1_Missense_Mutation_p.S725F	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	725					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ATCCGTACTTCCTATCAGAGT	0.393000													13	18					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41054925	41054925	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:41054925G>A	ENST00000399564.4	-	11	1501	c.1051C>T	c.(1051-1053)Cac>Tac	p.H351Y	MROH2B_ENST00000506092.2_Intron	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GAAATGATGTGATCCCTCAAC	0.373000													13	6					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161967678	161967678	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:161967678C>T	ENST00000294794.3	-	6	1834	c.1411G>A	c.(1411-1413)Gga>Aga	p.G471R	OLFML2B_ENST00000367940.2_Missense_Mutation_p.G472R	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	471										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGGGTTGTTCCCCACCCAGCA	0.567000													61	115					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179481212	179481212	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:179481212C>T	ENST00000589042.1	-	257	48530	c.48306G>A	c.(48304-48306)tgG>tgA	p.W16102*	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.W7037*|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.W13534*|TTN_ENST00000342175.6_Nonsense_Mutation_p.W7229*|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.W7162*|TTN_ENST00000591111.1_Nonsense_Mutation_p.W14461*|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14461	Ig-like 99.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACTTTAGTCCATGTTTTCC	0.438000													29	52					0	0	1	0	0
SLC35F6	54978	broad.mit.edu	37	2	26998033	26998033	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:26998033T>A	ENST00000344420.5	+	3	334	c.272T>A	c.(271-273)tTc>tAc	p.F91Y	SLC35F6_ENST00000482746.1_Intron|CENPA_ENST00000475662.1_Intron|SLC35F6_ENST00000416475.2_Intron	NM_017877.3	NP_060347.2			solute carrier family 35, member F6																		CCTCTTCTTTTCCTGCCCCCA	0.592000													27	32					0	0	1	0	0
AKR1B10	57016	broad.mit.edu	37	7	134216685	134216685	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:134216685C>T	ENST00000359579.4	+	3	580	c.260C>T	c.(259-261)cCc>cTc	p.P87L	AKR1B10_ENST00000475559.1_3'UTR	NM_020299.4	NP_064695.3	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10 (aldose reductase)	87			P -> S (in dbSNP:rs2303312).		cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(9)|skin(5)	20						TTTGAGAGACCCCTTGTGAGG	0.463000													23	52					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145113487	145113487	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:145113487C>T	ENST00000426825.1	-	6	776	c.695G>A	c.(694-696)gGg>gAg	p.G232E	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	232							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GGCCGTGTGCCCCCGAGGGAC	0.677000													14	28					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36155840	36155840	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr14:36155840G>C	ENST00000258840.6	-	19	2998	c.2608C>G	c.(2608-2610)Cct>Gct	p.P870A	RALGAPA1_ENST00000382366.3_Intron|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.P823A|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.P823A			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	823					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTATTAAGAGGAGGCAGTTTT	0.353000													7	3					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186938046	186938046	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:186938046C>T	ENST00000337774.5	-	16	2302	c.1913G>A	c.(1912-1914)gGa>gAa	p.G638E		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	638	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		GGCGTCCTTTCCCCCTAGGTG	0.537000											OREG0015972	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	4					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238245168	238245168	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:238245168G>A	ENST00000295550.4	-	40	9027	c.8575C>T	c.(8575-8577)Ccg>Tcg	p.P2859S	COL6A3_ENST00000472056.1_Missense_Mutation_p.P2252S|COL6A3_ENST00000409809.1_Missense_Mutation_p.P2653S|COL6A3_ENST00000347401.3_Missense_Mutation_p.P2658S|COL6A3_ENST00000353578.4_Missense_Mutation_p.P2653S|COL6A3_ENST00000346358.4_Missense_Mutation_p.P2659S	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2859	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACGTTATTCGGAACATTTCTG	0.393000													37	50					0	0	1	0	0
E4F1	1877	broad.mit.edu	37	16	2282857	2282857	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:2282857C>T	ENST00000301727.4	+	6	879	c.831C>T	c.(829-831)atC>atT	p.I277I	E4F1_ENST00000565090.1_Silent_p.I277I|E4F1_ENST00000564139.1_Silent_p.I277I	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	277					cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						CAGAGAAAATCCGCTTCAGTG	0.612000													34	29					0	0	1	0	0
CFHR1	3078	broad.mit.edu	37	1	196796131	196796131	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:196796131C>T	ENST00000320493.5	+	3	514	c.426C>T	c.(424-426)tcC>tcT	p.S142S	CFHR1_ENST00000367424.3_Silent_p.S142S|CFHR1_ENST00000498248.1_3'UTR|CFHR2_ENST00000367421.3_Intron	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	142	Sushi 2.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						AATGCAGGTCCACTGGTAAGT	0.373000													16	41					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359343	66359343	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:66359343G>A	ENST00000333861.3	-	1	1211	c.1144C>T	c.(1144-1146)Ctg>Ttg	p.L382L		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	382										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						ACAACCCCCAGGAGAGGAGGC	0.592000													24	36					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21098343	21098343	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:21098343C>T	ENST00000261383.3	-	19	2703	c.2704G>A	c.(2704-2706)Gag>Aag	p.E902K	DNAH3_ENST00000415178.1_Missense_Mutation_p.E902K	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	902	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TTCCCTATCTCCTCCGCAATT	0.463000													41	71					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44128516	44128516	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:44128516G>A	ENST00000260665.7	-	32	3569	c.3512C>T	c.(3511-3513)tCc>tTc	p.S1171F		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	1171	RNA-binding.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAGTCCAATGGAGTCTTCGAG	0.393000													22	37					0	0	1	0	0
MS4A15	219995	broad.mit.edu	37	11	60531279	60531279	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:60531279C>T	ENST00000405633.3	+	2	152	c.73C>T	c.(73-75)Cct>Tct	p.P25S	MS4A15_ENST00000528170.1_Missense_Mutation_p.P25S|MS4A15_ENST00000337911.4_Intron	NM_001098835.1	NP_001092305.1	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member 15	25						integral to membrane	receptor activity			breast(1)|large_intestine(2)|lung(3)	6						CCTCTGCCCACCTCCGGCCAT	0.602000													50	63					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803655	185803655	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:185803655C>T	ENST00000302277.6	+	4	4126	c.3532C>T	c.(3532-3534)Cat>Tat	p.H1178Y		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1178						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TTCCGTTCTTCATCCTAGCCA	0.512000													51	70					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43748789	43748789	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:43748789G>A	ENST00000263801.3	-	12	2254	c.2002C>T	c.(2002-2004)Cct>Tct	p.P668S	TP53BP1_ENST00000382039.3_Missense_Mutation_p.P673S|TP53BP1_ENST00000382044.4_Missense_Mutation_p.P673S|TP53BP1_ENST00000450115.2_Missense_Mutation_p.P673S	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	668					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GGTGTCTCAGGGATTTCTTCC	0.458000								Other conserved DNA damage response genes					29	53					0	0	1	0	0
CCL8	6355	broad.mit.edu	37	17	32647341	32647341	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:32647341C>T	ENST00000394620.1	+	2	596	c.130C>T	c.(130-132)Cct>Tct	p.P44S		NM_005623.2	NP_005614.2	P80075	CCL8_HUMAN	chemokine (C-C motif) ligand 8	44					calcium ion transport|cell-cell signaling|chemotaxis|exocytosis|immune response|inflammatory response|response to virus	extracellular space	chemokine activity|heparin binding|signal transducer activity			NS(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Ovarian(249;0.0443)|Breast(31;0.151)				TAGGAAAATTCCTATCCAGAG	0.443000													12	27					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156631888	156631888	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr4:156631888C>T	ENST00000296518.7	+	6	780	c.571C>T	c.(571-573)Cta>Tta	p.L191L	GUCY1A3_ENST00000506455.1_Silent_p.L191L|GUCY1A3_ENST00000513574.1_Silent_p.L191L|GUCY1A3_ENST00000511108.1_Silent_p.L191L|GUCY1A3_ENST00000455639.2_Silent_p.L191L|GUCY1A3_ENST00000393832.3_5'UTR|GUCY1A3_ENST00000511507.1_Silent_p.L191L			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	191					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CGCCTCCATTCTATGCCTGGA	0.463000													12	4					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36155855	36155855	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr14:36155855T>G	ENST00000258840.6	-	19	2983	c.2593A>C	c.(2593-2595)Agc>Cgc	p.S865R	RALGAPA1_ENST00000382366.3_Intron|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.S818R|RALGAPA1_ENST00000389698.3_Missense_Mutation_p.S818R			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	818					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AGTTTTTGGCTCATGTCCTCT	0.348000													8	2					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2432922	2432922	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:2432922G>A	ENST00000452833.1	-	17	2564	c.2556C>T	c.(2554-2556)atC>atT	p.I852I	TRPM5_ENST00000155858.6_Silent_p.I850I|TRPM5_ENST00000533060.1_Silent_p.I850I|TRPM5_ENST00000528453.1_Silent_p.I850I			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	850						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CAAAGATATGGATCAGCCGCA	0.642000													34	14					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89347696	89347696	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:89347696G>A	ENST00000301030.4	-	9	5714	c.5254C>T	c.(5254-5256)Ccc>Tcc	p.P1752S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1752S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1752						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCGCTGGTGGGAGCGGTGGGC	0.667000													22	46					0	0	1	0	0
SALL4	57167	broad.mit.edu	37	20	50400980	50400980	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:50400980G>A	ENST00000217086.4	-	4	3097	c.2986C>T	c.(2986-2988)Cct>Tct	p.P996S	SALL4_ENST00000395997.3_Missense_Mutation_p.P559S|SALL4_ENST00000371539.3_Missense_Mutation_p.P219S	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	996					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GGGAGGGTAGGAACCCCCCCA	0.557000													17	30					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6061031	6061031	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:6061031G>A	ENST00000261405.5	-	50	8388	c.8134C>T	c.(8134-8136)Cca>Tca	p.P2712S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2712					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CAGGTGCCTGGAATTTTCATA	0.443000													14	44					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47882633	47882633	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:47882633G>A	ENST00000289672.2	-	34	5422	c.5372C>T	c.(5371-5373)tCc>tTc	p.S1791F		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1791					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GCCCGGCAGGGAAGCTTCTTG	0.473000													8	18					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7416106	7416106	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:7416106C>T	ENST00000322644.6	+	28	5019	c.4620C>T	c.(4618-4620)acC>acT	p.T1540T		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1540					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GTGGAATGACCCCAGGGGCAG	0.632000													36	70					0	0	1	0	0
MYF6	4618	broad.mit.edu	37	12	81101802	81101802	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:81101802G>A	ENST00000228641.3	+	1	526	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K		NM_002469.2	NP_002460.1	P23409	MYF6_HUMAN	myogenic factor 6 (herculin)	102					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						CACCCTGCGCGAAAGGAGGAG	0.607000													23	36					0	0	1	0	0
TRBV6-6	28601	broad.mit.edu	37	7	142162077	142162077	+	RNA	SNP	A	A	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:142162077A>T	ENST00000390371.3	-	0	241																											CAACTGAATAATAAATCAGCT	0.483000													67	91					0	0	1	0	0
IQCG	84223	broad.mit.edu	37	3	197659062	197659062	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:197659062G>A	ENST00000265239.6	-	6	1051	c.627C>T	c.(625-627)ttC>ttT	p.F209F	IQCG_ENST00000455191.1_Silent_p.F209F|IQCG_ENST00000453254.1_Silent_p.F209F	NM_032263.3	NP_115639.1	Q9H095	IQCG_HUMAN	IQ motif containing G	209										autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		TGATGTCATAGAAATGCATTT	0.393000													28	15					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70981045	70981045	+	Missense_Mutation	SNP	G	G	A	rs3960114		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:70981045G>A	ENST00000334414.6	-	9	2097	c.2053C>T	c.(2053-2055)Ccc>Tcc	p.P685S	PTPRB_ENST00000550857.1_Missense_Mutation_p.P377S|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000261266.5_Missense_Mutation_p.P467S|PTPRB_ENST00000451516.2_Missense_Mutation_p.P377S|PTPRB_ENST00000550358.1_Missense_Mutation_p.P685S|PTPRB_ENST00000551525.1_Missense_Mutation_p.P684S|PTPRB_ENST00000538708.1_Missense_Mutation_p.P467S	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	467	Fibronectin type-III 8.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.P467S(2)|p.P685S(1)		breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACAGCCAGGGGGACTGAGGAA	0.458000													11	9					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35533870	35533870	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:35533870G>A	ENST00000262878.4	-	12	1506	c.1307C>T	c.(1306-1308)cCc>cTc	p.P436L		NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	436					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TTTCAATTTGGGATCAGTAGA	0.299000													13	31					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228528583	228528583	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:228528583C>T	ENST00000570156.2	+	83	20636	c.20562C>T	c.(20560-20562)atC>atT	p.I6854I	OBSCN_ENST00000366709.4_Silent_p.I3016I|OBSCN_ENST00000366707.4_Silent_p.I3531I|OBSCN_ENST00000422127.1_Silent_p.I5897I|OBSCN_ENST00000284548.11_Silent_p.I5897I	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5897					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCGAGCCCATCCGCCAGGTTG	0.672000													5	5					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75688769	75688769	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:75688769G>A	ENST00000394947.3	-	13	2237	c.1923C>T	c.(1921-1923)tcC>tcT	p.S641S	SIN3A_ENST00000360439.4_Silent_p.S641S|SIN3A_ENST00000394949.4_Silent_p.S641S	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	641	Interaction with NCOR1 (By similarity).|Interactions with SUDS3 and SAP130.				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						CAGACAAGCGGGAAAGCTTCT	0.463000													18	36					0	0	1	0	0
VPREB1	7441	broad.mit.edu	37	22	22599596	22599596	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr22:22599596G>A	ENST00000403807.3	+	2	424	c.285G>A	c.(283-285)agG>agA	p.R95R	VPREB1_ENST00000302273.2_Silent_p.R94R			P12018	VPREB_HUMAN	pre-B lymphocyte 1	95	Framework-3.|Ig-like V-type.				immune response	extracellular region	antigen binding|protein binding			large_intestine(1)|liver(1)|lung(6)|skin(1)	9	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		ATGTGGCCAGGAACAGGGGGT	0.582000													20	25					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5123046	5123046	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:5123046C>T	ENST00000381652.3	+	23	3596	c.3102C>T	c.(3100-3102)gcC>gcT	p.A1034A	JAK2_ENST00000539801.1_Silent_p.A1034A|JAK2_ENST00000544510.1_Silent_p.A885A	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	1034	Protein kinase 2.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TTTCTGTGGCCTCAGATGTTT	0.373000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				12	12					0	0	1	0	0
ZAK	51776	broad.mit.edu	37	2	174125863	174125863	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:174125863G>A	ENST00000375213.3	+	18	1627	c.1549G>A	c.(1549-1551)Gag>Aag	p.E517K	MLTK_ENST00000409176.2_Missense_Mutation_p.E517K|MLK7-AS1_ENST00000422703.1_RNA|MLK7-AS1_ENST00000423106.2_RNA	NM_016653.2	NP_057737.2																					TGTCACATATGAGGTAAGCTC	0.403000													14	25					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88125461	88125461	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:88125461G>A	ENST00000507897.1	+	5	424	c.341G>A	c.(340-342)cGa>cAa	p.R114Q	C6ORF165_ENST00000369562.4_Missense_Mutation_p.R114Q			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	114										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		TCTGTTACCCGAGAAATTACA	0.398000													24	30					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56515402	56515402	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:56515402G>A	ENST00000390649.3	+	2	383	c.383G>A	c.(382-384)aGc>aAc	p.S128N		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	128	DAPIN.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ACGTCCATTAGCATCTTTGAA	0.507000													15	30					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111689212	111689212	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:111689212G>A	ENST00000435970.1	-	16	6361	c.5545C>T	c.(5545-5547)Ctc>Ttc	p.L1849F	REV3L_ENST00000368805.1_Missense_Mutation_p.L1927F|REV3L_ENST00000368802.3_Missense_Mutation_p.L1927F|REV3L_ENST00000358835.3_Missense_Mutation_p.L1927F			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1927	Mediates interaction with MAD2L2.				DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TCTACCATGAGGAGCCGTCCA	0.383000								DNA polymerases (catalytic subunits)					12	13					0	0	1	0	0
TIMM44	10469	broad.mit.edu	37	19	7998826	7998826	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:7998826C>T	ENST00000270538.3	-	6	874	c.606G>A	c.(604-606)cgG>cgA	p.R202R		NM_006351.3	NP_006342.2	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44 homolog (yeast)	202					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	17						GCTGGGGCCTCCGGTAGGGCC	0.622000													20	30					0	0	1	0	0
B4GALNT4	338707	broad.mit.edu	37	11	379575	379575	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:379575G>T	ENST00000329962.6	+	15	2362	c.2362G>T	c.(2362-2364)Gat>Tat	p.D788Y		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	788						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCGCGTAGGGGATGCAGACGG	0.746000													6	1					8.12818e-05	8.19136e-05	1	1	0
PLAG1	5324	broad.mit.edu	37	8	57079381	57079381	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:57079381G>A	ENST00000316981.3	-	5	1403	c.924C>T	c.(922-924)atC>atT	p.I308I	PLAG1_ENST00000423799.2_Silent_p.I226I|PLAG1_ENST00000429357.2_Silent_p.I308I	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	308	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GTAAAGTTGTGATCATTTGGT	0.428000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								50	75					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814408	106814408	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:106814408G>A	ENST00000407775.2	+	8	2348	c.2098G>A	c.(2098-2100)Gaa>Aaa	p.E700K	RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000520492.1_Missense_Mutation_p.E568K|ZFPM2_ENST00000378472.4_Missense_Mutation_p.E431K|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.E568K|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000520594.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	700					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CAGCCGGCACGAAACATACAT	0.488000													9	15					0	0	1	0	0
SULT2B1	6820	broad.mit.edu	37	19	49079341	49079341	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:49079341G>A	ENST00000323090.4	+	1	544		c.e1+1		SULT2B1_ENST00000201586.2_Splice_Site	NM_004605.2	NP_004596.2	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1						3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	11		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		CCCAAGTCAGGTACCTGCCGG	0.622000													32	42					0	0	1	0	0
RIMKLA	284716	broad.mit.edu	37	1	42880551	42880551	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:42880551C>T	ENST00000431473.3	+	5	1211	c.1082C>T	c.(1081-1083)tCc>tTc	p.S361F		NM_173642.3	NP_775913.2	Q8IXN7	RIMKA_HUMAN	ribosomal modification protein rimK-like family member A	361					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						ATCCGGGATTCCTCAGCAAGC	0.512000													28	22					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10091971	10091971	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:10091971G>A	ENST00000324907.9	+	1	145	c.9G>A	c.(7-9)caG>caA	p.Q3Q	GRHL1_ENST00000405379.2_Intron|GRHL1_ENST00000324883.5_5'UTR	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	3	Transcription activation.				cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		CGATGACACAGGAGTACGACA	0.751000													8	16					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110980759	110980759	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:110980759G>A	ENST00000524391.1	-	4	2093	c.1061C>T	c.(1060-1062)tCc>tTc	p.S354F	KCNV1_ENST00000297404.1_Missense_Mutation_p.S354F			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	354						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GATTCCCACGGATAGAAATAG	0.473000													12	27					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128389909	128389909	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:128389909T>C	ENST00000389524.4	+	38	5316	c.5263T>C	c.(5263-5265)Ttt>Ctt	p.F1755L	MYO7B_ENST00000409816.2_Missense_Mutation_p.F1754L|MYO7B_ENST00000428314.1_Missense_Mutation_p.F1754L|MYO7B_ENST00000409090.1_Missense_Mutation_p.F607L			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1754	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGCCCAGAAGTTTATAGACAC	0.667000													44	60					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141819654	141819654	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:141819654C>T	ENST00000389484.3	-	8	2173	c.1202G>A	c.(1201-1203)gGa>gAa	p.G401E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	401					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTATTTTTTCCTTGATAGTC	0.393000										TSP Lung(27;0.18)			35	46					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133152325	133152325	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:133152325G>A	ENST00000388996.4	-	11	1986	c.1566C>T	c.(1564-1566)gtC>gtT	p.V522V	KCNQ3_ENST00000521134.1_Silent_p.V402V|KCNQ3_ENST00000519445.1_Silent_p.V522V	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	522					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GGCATTACCTGACGGCTCGGA	0.592000													18	39					0	0	1	0	0
TCEAL2	140597	broad.mit.edu	37	X	101381968	101381968	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chrX:101381968G>A	ENST00000372780.1	+	3	385	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K	TCEAL2_ENST00000329035.2_Missense_Mutation_p.E56K	NM_080390.3	NP_525129.1	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	56					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						GAGAGTTGAGGAACCGTTAAA	0.473000													12	3					0	0	1	0	0
CHODL	140578	broad.mit.edu	37	21	19629108	19629108	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr21:19629108G>A	ENST00000299295.2	+	2	753	c.362G>A	c.(361-363)tGg>tAg	p.W121*	CHODL_ENST00000400127.1_Nonsense_Mutation_p.W80*|CHODL_ENST00000400128.1_Nonsense_Mutation_p.W80*|CHODL_ENST00000543733.1_Nonsense_Mutation_p.W102*|CHODL_ENST00000338326.3_Nonsense_Mutation_p.W80*|CHODL_ENST00000400135.1_Nonsense_Mutation_p.W80*|CHODL_ENST00000400131.1_Nonsense_Mutation_p.W80*	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	121	C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		CTCTACCAGTGGTCTGATGGA	0.517000													40	34					0	0	1	0	0
TTLL4	9654	broad.mit.edu	37	2	219617604	219617604	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:219617604C>T	ENST00000392102.1	+	17	3435	c.3095C>T	c.(3094-3096)tCc>tTc	p.S1032F	TTLL4_ENST00000457313.1_Missense_Mutation_p.S867F|TTLL4_ENST00000442769.1_Missense_Mutation_p.S968F|TTLL4_ENST00000258398.4_Missense_Mutation_p.S1032F	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	1032					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TCTCATATCTCCTCTCGCTAT	0.448000													33	68					0	0	1	0	0
BCL9	607	broad.mit.edu	37	1	147092129	147092129	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:147092129A>C	ENST00000234739.3	+	8	2908	c.2168A>C	c.(2167-2169)aAt>aCt	p.N723T		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	723	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					GTCAATCTAAATGTCAACATG	0.527000			T	"""IGH@, IGL@"""	B-ALL								10	21					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48142390	48142390	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:48142390T>A	ENST00000311303.3	-	17	2677	c.2332A>T	c.(2332-2334)Acc>Tcc	p.T778S	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_Missense_Mutation_p.T775S	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	778						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GTTTTCCAGGTCACGGTTCCT	0.458000													16	27					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242287823	242287823	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:242287823C>T	ENST00000442594.2	-	7	1113	c.604G>A	c.(604-606)Gaa>Aaa	p.E202K	PLD5_ENST00000536534.1_Missense_Mutation_p.E294K|PLD5_ENST00000427495.1_Missense_Mutation_p.E232K	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	294						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AATTTCTTTTCATTGTCATAG	0.378000													17	20					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962611	41962611	+	RNA	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:41962611C>T	ENST00000454645.1	-	0	893					NR_003670.1																						TGTTTTTTTTCCTCTTACAGG	0.373000													3	14					0	0	1	0	0
IL37	27178	broad.mit.edu	37	2	113676334	113676334	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:113676334C>T	ENST00000263326.3	+	5	647	c.605C>T	c.(604-606)tCa>tTa	p.S202L	IL37_ENST00000353225.3_Missense_Mutation_p.S162L|IL37_ENST00000352179.3_Missense_Mutation_p.S181L|IL37_ENST00000349806.3_Missense_Mutation_p.S141L|IL37_ENST00000311328.2_Missense_Mutation_p.S176L	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	202					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						ATTGAATTTTCATTTCAACCA	0.458000													16	25					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42804856	42804856	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:42804856G>A	ENST00000514985.1	-	4	692	c.436C>T	c.(436-438)Cat>Tat	p.H146Y	SEPP1_ENST00000507920.1_Intron|SEPP1_ENST00000511224.1_Missense_Mutation_p.H146Y|SEPP1_ENST00000506577.1_Missense_Mutation_p.H146Y|SEPP1_ENST00000509276.1_5'UTR	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1	146					response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						AAACCAAGATGATATACAAGA	0.368000													22	4					0	0	1	0	0
GGA3	23163	broad.mit.edu	37	17	73237572	73237572	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:73237572G>A	ENST00000245541.6	-	10	1071	c.855C>T	c.(853-855)aaC>aaT	p.N285N	GGA3_ENST00000578348.1_Silent_p.N163N|GGA3_ENST00000537686.1_3'UTR|GGA3_ENST00000538886.1_Silent_p.N163N|GGA3_ENST00000351904.7_Silent_p.N252N|GGA3_ENST00000582717.1_Silent_p.N213N|GGA3_ENST00000582486.1_Silent_p.N213N	NM_138619.2	NP_619525.1	Q9NZ52	GGA3_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	285	Binds to ARF1 (in long isoform).|GAT.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			breast(2)|endometrium(3)|large_intestine(4)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	20			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			CCCGGGAGAGGTTGTCACTGG	0.517000													55	24					0	0	1	0	0
ZNF415	55786	broad.mit.edu	37	19	53613010	53613010	+	Silent	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:53613010A>G	ENST00000455735.2	-	7	752	c.432T>C	c.(430-432)ttT>ttC	p.F144F	ZNF415_ENST00000440291.1_Silent_p.F83F|ZNF415_ENST00000597748.1_3'UTR|ZNF415_ENST00000595193.1_3'UTR|ZNF415_ENST00000601493.1_5'UTR|ZNF415_ENST00000594011.1_3'UTR|ZNF415_ENST00000500065.4_Silent_p.F96F|ZNF415_ENST00000243643.4_Silent_p.F96F|ZNF415_ENST00000448501.1_Silent_p.F144F|ZNF415_ENST00000597503.1_3'UTR|ZNF415_ENST00000601215.1_3'UTR|ZNF415_ENST00000421033.1_Silent_p.F108F			Q09FC8	ZN415_HUMAN	zinc finger protein 415	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		ACTGACAGTCAAAGTCGTGTA	0.398000													19	40					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61747770	61747770	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:61747770C>T	ENST00000577390.1	-	10	2583	c.1629G>A	c.(1627-1629)ccG>ccA	p.P543P	CDH8_ENST00000299345.6_Silent_p.P543P|CDH8_ENST00000580044.1_5'UTR|CDH8_ENST00000577730.1_Silent_p.P543P	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	543	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P543P(1)		biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TGGTGAAATTCGGATTGTTGA	0.333000													8	13					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187594	152187594	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:152187594C>G	ENST00000368801.2	-	3	6586	c.6511G>C	c.(6511-6513)Ggc>Cgc	p.G2171R	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2171					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGGCCGTGGCCCGAAGACTGA	0.627000													34	696					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699242	43699242	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:43699242G>A	ENST00000405312.3	-	4	1130	c.893C>T	c.(892-894)cCc>cTc	p.P298L	PSG4_ENST00000433626.2_Missense_Mutation_p.P205L|PSG4_ENST00000244295.9_Intron	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	298	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				CGTGACATTGGGTAGAATGAG	0.483000													75	19					0	0	1	0	0
BTN3A1	11119	broad.mit.edu	37	6	26413719	26413719	+	Silent	SNP	C	C	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:26413719C>A	ENST00000289361.6	+	10	1709	c.1341C>A	c.(1339-1341)ccC>ccA	p.P447P	BTN3A1_ENST00000414912.2_Silent_p.P395P	NM_001145008.1|NM_001145009.1|NM_007048.5	NP_001138480.1|NP_001138481.1|NP_008979.3	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1	447	B30.2/SPRY.				lipid metabolic process	integral to membrane				breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						TAACTGAGCCCAGAACCAACC	0.478000													27	68					7.92952e-12	8.18192e-12	1	1	0
KIAA0907	22889	broad.mit.edu	37	1	155883916	155883916	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:155883916G>A	ENST00000368321.3	-	14	1864	c.1841C>T	c.(1840-1842)cCc>cTc	p.P614L	KIAA0907_ENST00000368320.3_3'UTR	NM_014949.2	NP_055764.2	Q7Z7F0	K0907_HUMAN	KIAA0907	614										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			TGTTTCCTAGGGAGCCATCCA	0.448000													13	25					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171218	207171218	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:207171218C>T	ENST00000374423.3	+	5	2352	c.1966C>T	c.(1966-1968)Ctt>Ttt	p.L656F		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	656							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GAATGCTGACCTTATGGATAT	0.433000													18	23					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55533563	55533563	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:55533563C>T	ENST00000220676.1	+	2	185	c.37C>T	c.(37-39)Cat>Tat	p.H13Y		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	13					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCCATCATTCATCCTACGTC	0.463000													37	51					0	0	1	0	0
PSTPIP2	9050	broad.mit.edu	37	18	43585483	43585483	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr18:43585483C>T	ENST00000409746.5	-	6	440	c.369G>A	c.(367-369)atG>atA	p.M123I	PSTPIP2_ENST00000589328.1_Missense_Mutation_p.M123I|PSTPIP2_ENST00000588801.1_5'UTR	NM_024430.3	NP_077748.3	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting protein 2	123						membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	17						GGATAGCATCCATTATGAGCT	0.294000													6	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179623779	179623779	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:179623779C>T	ENST00000589042.1	-	44	10459	c.10235G>A	c.(10234-10236)gGa>gAa	p.G3412E	TTN_ENST00000360870.5_Missense_Mutation_p.G3412E|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G3366E|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G3412E|TTN_ENST00000342175.6_Missense_Mutation_p.G3366E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G3366E|TTN_ENST00000591111.1_Missense_Mutation_p.G3412E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3125	Ig-like 20.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGTGTAAGTTCCTTCATCTTC	0.398000													25	32					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8791862	8791862	+	Silent	SNP	G	G	A	rs139885994		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:8791862G>A	ENST00000447110.1	-	10	1366	c.1242C>T	c.(1240-1242)caC>caT	p.H414H	PIK3R5_ENST00000584803.1_Silent_p.H414H|PIK3R5_ENST00000581552.1_Silent_p.H414H	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	414					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						CAGGCCTGCGGTGGCCTCGGC	0.637000													7	5					0	0	1	0	0
SDCCAG8	10806	broad.mit.edu	37	1	243471382	243471382	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:243471382C>T	ENST00000366541.3	+	8	950	c.832C>T	c.(832-834)Cgt>Tgt	p.R278C	SDCCAG8_ENST00000355875.4_Missense_Mutation_p.R235C|SDCCAG8_ENST00000391846.1_Missense_Mutation_p.R278C|SDCCAG8_ENST00000343783.6_Missense_Mutation_p.R133C	NM_006642.3	NP_006633.1	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	278	Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TACTTGTAACCGTGTTGGTGG	0.378000													40	56					0	0	1	0	0
DNASE1L2	1775	broad.mit.edu	37	16	2286876	2286876	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:2286876C>A	ENST00000564065.1	+	1	1060	c.59C>A	c.(58-60)gCc>gAc	p.A20D	DNASE1L2_ENST00000567494.1_Missense_Mutation_p.A20D|RP11-304L19.12_ENST00000564055.1_lincRNA|DNASE1L2_ENST00000320700.5_Missense_Mutation_p.A20D|DNASE1L2_ENST00000382437.4_Missense_Mutation_p.A20D			Q92874	DNSL2_HUMAN	deoxyribonuclease I-like 2	20					DNA catabolic process	extracellular region	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|protein binding			endometrium(1)|prostate(1)|skin(2)	4						GCCGGGACCGCCGCGCTTCGC	0.711000													7	12					8.12818e-05	8.19136e-05	1	1	0
MAGEC3	139081	broad.mit.edu	37	X	140985038	140985038	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chrX:140985038C>T	ENST00000298296.1	+	7	1494	c.1494C>T	c.(1492-1494)ttC>ttT	p.F498F	MAGEC3_ENST00000544766.1_Silent_p.F200F|MAGEC3_ENST00000536088.1_Silent_p.F200F|MAGEC3_ENST00000443323.2_Silent_p.F120F|MAGEC3_ENST00000409007.1_Silent_p.F200F	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	498	MAGE 2.							p.F498F(1)|p.F200F(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					CCATGATCTTCGGGAAAGCCC	0.423000													32	14					0	0	1	0	0
AQP9	366	broad.mit.edu	37	15	58467155	58467155	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:58467155G>A	ENST00000219919.4	+	4	785	c.415G>A	c.(415-417)Gtg>Atg	p.V139M	ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000558772.1_Missense_Mutation_p.V74M|AQP9_ENST00000536493.1_Missense_Mutation_p.V139M	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9	139					cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity	p.V139M(1)		endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		ACTGCTGATCGTGGGAGAAAA	0.453000													20	25					0	0	1	0	0
AURKA	6790	broad.mit.edu	37	20	54956600	54956600	+	Silent	SNP	A	A	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:54956600A>C	ENST00000395909.4	-	8	1159	c.594T>G	c.(592-594)ggT>ggG	p.G198G	AURKA_ENST00000395913.3_Silent_p.G198G|AURKA_ENST00000347343.2_Silent_p.G198G|AURKA_ENST00000395907.1_Silent_p.G198G|AURKA_ENST00000312783.6_Silent_p.G198G|AURKA_ENST00000371356.2_Silent_p.G198G|AURKA_ENST00000395911.1_Silent_p.G198G|AURKA_ENST00000395915.3_Silent_p.G198G|AURKA_ENST00000395914.1_Silent_p.G198G	NM_198433.1	NP_940835.1	O14965	AURKA_HUMAN	aurora kinase A	198	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|phosphatidylinositol-mediated signaling|regulation of protein stability|spindle organization	cytosol|nucleus|perinuclear region of cytoplasm|spindle microtubule|spindle pole centrosome	ATP binding|protein kinase binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|lung(9)|ovary(2)|prostate(1)|skin(2)	22			Colorectal(105;0.202)			CATGGAAATAACCATACAGTC	0.363000													19	22					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18377106	18377106	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:18377106G>A	ENST00000392413.3	-	3	1459	c.1244C>T	c.(1243-1245)cCa>cTa	p.P415L	KIAA1683_ENST00000600328.2_Missense_Mutation_p.P415L|KIAA1683_ENST00000600359.2_Missense_Mutation_p.P369L	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	415	Thr-rich.					mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TGTCTGCCGTGGGGTGCCAGT	0.602000													28	38					0	0	1	0	0
RP11-298I3.5	0	broad.mit.edu	37	14	23416839	23416839	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr14:23416839G>A	ENST00000555074.1	-	3	297	c.298C>T	c.(298-300)Caa>Taa	p.Q100*	HAUS4_ENST00000397409.4_Silent_p.V144V|HAUS4_ENST00000555367.1_Silent_p.V225V|HAUS4_ENST00000554446.1_5'UTR|HAUS4_ENST00000347758.2_Silent_p.V144V|HAUS4_ENST00000541587.1_Silent_p.V270V|HAUS4_ENST00000555986.1_Silent_p.V225V|HAUS4_ENST00000342454.8_Silent_p.V225V|RP11-298I3.1_ENST00000548819.1_RNA|HAUS4_ENST00000206474.7_Silent_p.V270V|HAUS4_ENST00000490506.1_Silent_p.V146V|RP11-298I3.1_ENST00000548322.1_RNA																							CACCGCACTTGACTTCCAGGT	0.517000													28	25					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40585785	40585785	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:40585785C>T	ENST00000260402.3	-	20	2451	c.2202G>A	c.(2200-2202)aaG>aaA	p.K734K	PLCB2_ENST00000557821.1_Silent_p.K730K|PLCB2_ENST00000456256.2_Silent_p.K734K	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	734	C2.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		AGGGCTCCTCCTTCCAGACAG	0.527000													40	54					0	0	1	0	0
LENG1	79165	broad.mit.edu	37	19	54660640	54660640	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:54660640G>A	ENST00000222224.3	-	3	622	c.436C>T	c.(436-438)Cca>Tca	p.P146S		NM_024316.1	NP_077292.1	Q96BZ8	LENG1_HUMAN	leukocyte receptor cluster (LRC) member 1	146										breast(1)|endometrium(3)|large_intestine(2)|lung(1)|ovary(1)	8	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TTCTCATCTGGGGCTGGGCCG	0.647000													39	49					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307062	14307062	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:14307062A>G	ENST00000378053.3	-	2	1347	c.1091T>C	c.(1090-1092)aTt>aCt	p.I364T	MACROD2_ENST00000310348.4_Intron|FLRT3_ENST00000341420.4_Missense_Mutation_p.I364T|MACROD2_ENST00000217246.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	364					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GGTTATCTGAATGGTGCTTAC	0.488000													34	60					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66489964	66489964	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:66489964T>G	ENST00000359626.5	+	7	1103	c.939T>G	c.(937-939)gaT>gaG	p.D313E		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	313					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				CCATTGTTGATGTTGAAGATT	0.423000													23	26					0	0	1	0	0
RND1	27289	broad.mit.edu	37	12	49251968	49251968	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:49251968G>A	ENST00000309739.5	-	5	640	c.510C>T	c.(508-510)ttC>ttT	p.F170F		NM_014470.3	NP_055285.1	Q92730	RND1_HUMAN	Rho family GTPase 1	170					actin filament organization|axon guidance|negative regulation of cell adhesion|neuron remodeling|small GTPase mediated signal transduction	adherens junction|cytoskeleton|cytosol	GTP binding|GTPase activity|receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(2)|skin(1)|urinary_tract(1)	10						TTTCTGAGGTGAAAGCTGAGC	0.552000													19	38					0	0	1	0	0
CHAC2	494143	broad.mit.edu	37	2	54001462	54001462	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:54001462C>T	ENST00000295304.4	+	3	450	c.355C>T	c.(355-357)Ctt>Ttt	p.L119F	GPR75-ASB3_ENST00000394717.2_Intron|ASB3_ENST00000406625.2_Intron|GPR75-ASB3_ENST00000352846.3_Intron|GPR75-ASB3_ENST00000406687.1_Intron|GPR75-ASB3_ENST00000263634.3_Intron|ASB3_ENST00000498475.2_Intron	NM_001008708.2	NP_001008708.1	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator homolog 2 (E. coli)	119										endometrium(1)|large_intestine(2)|lung(4)|prostate(1)	8			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCCTGATTATCTTGGTCCTGC	0.358000													22	41					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112686862	112686862	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:112686862G>A	ENST00000295408.4	+	2	484	c.227G>A	c.(226-228)gGa>gAa	p.G76E	MERTK_ENST00000409780.1_Intron|MERTK_ENST00000421804.2_Missense_Mutation_p.G76E			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	76					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						CCACATACAGGAAACGTAGCC	0.507000													14	24					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107097078	107097078	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:107097078C>T	ENST00000261058.1	+	1	891	c.644C>T	c.(643-645)cCc>cTc	p.P215L		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	215								p.P215H(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						ACAATTTCTCCCCAAATGAAA	0.393000													18	20					0	0	1	0	0
OR10A4	283297	broad.mit.edu	37	11	6898580	6898580	+	Silent	SNP	G	G	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:6898580G>C	ENST00000379829.2	+	1	725	c.702G>C	c.(700-702)ggG>ggC	p.G234G		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAGCTGAGGGGAAACATCAGG	0.517000													24	14					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103978	53103978	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:53103978G>A	ENST00000408890.4	+	1	630	c.614G>A	c.(613-615)gGt>gAt	p.G205D		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	205										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GACAGCAAGGGTGGCAGGCGG	0.667000													30	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083238	9083238	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:9083238G>A	ENST00000397910.4	-	1	8780	c.8577C>T	c.(8575-8577)ctC>ctT	p.L2859L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2859	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGGTGTTAGGAGGCCTGACT	0.527000													7	4					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135429496	135429496	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chrX:135429496G>A	ENST00000394143.1	+	6	3922	c.3631G>A	c.(3631-3633)Gat>Aat	p.D1211N	GPR112_ENST00000412101.1_Missense_Mutation_p.D1006N|GPR112_ENST00000394141.1_Missense_Mutation_p.D1006N|GPR112_ENST00000370652.1_Missense_Mutation_p.D1211N|GPR112_ENST00000287534.4_Missense_Mutation_p.D1148N	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1211					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTCTGTTGTTGATGAGACCAC	0.473000													67	16					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	61					0	0	1	0	0
D2HGDH	728294	broad.mit.edu	37	2	242707241	242707241	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:242707241G>A	ENST00000321264.4	+	10	1632	c.1423G>A	c.(1423-1425)Gag>Aag	p.E475K	D2HGDH_ENST00000486953.1_3'UTR|D2HGDH_ENST00000403782.1_Missense_Mutation_p.E341K	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	475					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		CGTCAGCGCGGAGCACGGAGT	0.692000													13	15					0	0	1	0	0
NME7	29922	broad.mit.edu	37	1	169102023	169102023	+	Nonstop_Mutation	SNP	C	C	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:169102023C>A	ENST00000367811.3	-	12	1387	c.1131G>T	c.(1129-1131)taG>taT	p.*377Y	NME7_ENST00000472647.1_Nonstop_Mutation_p.*341Y	NM_013330.3	NP_037462.1	Q9Y5B8	NDK7_HUMAN	NME/NM23 family member 7	0					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(8)|skin(1)	16	all_hematologic(923;0.208)					TTCCACACCACTAATTATCCA	0.363000													12	25					1.52009e-12	1.57265e-12	1	1	0
HMCN1	83872	broad.mit.edu	37	1	185976290	185976290	+	Silent	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:185976290A>G	ENST00000271588.4	+	30	4735	c.4506A>G	c.(4504-4506)gaA>gaG	p.E1502E	HMCN1_ENST00000367492.2_Silent_p.E1502E	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1502	Ig-like C2-type 12.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CTAATGTTGAACTTCTAGACA	0.368000													21	49					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2057191	2057191	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:2057191C>T	ENST00000262113.4	+	25	3190	c.3049C>T	c.(3049-3051)Cct>Tct	p.P1017S	MYOM2_ENST00000523438.1_Missense_Mutation_p.P442S	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1017					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TGTAGCAATTCCTCTGAAATC	0.408000													11	15					0	0	1	0	0
TREM1	54210	broad.mit.edu	37	6	41250182	41250182	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:41250182G>A	ENST00000591620.1	-	2	383	c.357C>T	c.(355-357)ccC>ccT	p.P119P	TREM1_ENST00000589614.1_Silent_p.P119P|TREM1_ENST00000244709.4_Silent_p.P119P|TREM1_ENST00000334475.6_Silent_p.P119P	NM_001242589.1	NP_001229518.1	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	119	Ig-like V-type.				blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			NS(1)|breast(2)|endometrium(2)|large_intestine(5)|lung(5)|skin(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	GAGGCTCCTTGGGAGGCTGGT	0.542000													12	28					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57089032	57089032	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:57089032T>C	ENST00000330619.8	+	6	1921	c.1235T>C	c.(1234-1236)cTt>cCt	p.L412P	ZNF470_ENST00000601902.1_Intron|ZNF470_ENST00000391709.3_Missense_Mutation_p.L412P	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		CACATAGGACTTATTCAGCAT	0.418000													9	29					0	0	1	0	0
CD34	947	broad.mit.edu	37	1	208062533	208062533	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:208062533C>T	ENST00000356522.4	-	6	1101	c.780G>A	c.(778-780)atG>atA	p.M260I	CD34_ENST00000367036.3_Missense_Mutation_p.M102I|CD34_ENST00000485761.1_5'UTR|CD34_ENST00000537704.1_Missense_Mutation_p.M125I|CD34_ENST00000310833.7_Missense_Mutation_p.M260I	NM_001773.2	NP_001764.1	P28906	CD34_HUMAN	CD34 molecule	260					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						GGTGCTTTTTCATAAGTTGGA	0.483000													36	63					0	0	1	0	0
HPD	3242	broad.mit.edu	37	12	122292672	122292672	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:122292672G>A	ENST00000543163.1	-	8	679	c.234C>T	c.(232-234)atC>atT	p.I78I	HPD_ENST00000289004.4_Silent_p.I117I	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	117					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	GCTCCCGCATGATTTTGGCGC	0.597000													28	60					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87338524	87338524	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:87338524C>T	ENST00000304053.6	+	7	1103	c.620C>T	c.(619-621)aCt>aTt	p.T207I	NTRK2_ENST00000359847.3_Missense_Mutation_p.T207I|NTRK2_ENST00000376208.1_Missense_Mutation_p.T207I|NTRK2_ENST00000277120.3_Missense_Mutation_p.T207I|NTRK2_ENST00000323115.4_Missense_Mutation_p.T207I|NTRK2_ENST00000395866.2_Missense_Mutation_p.T51I|NTRK2_ENST00000376213.1_Missense_Mutation_p.T207I|NTRK2_ENST00000376214.1_Missense_Mutation_p.T207I|NTRK2_ENST00000395882.1_Missense_Mutation_p.T207I	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	207	Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						CCTAACCTCACTGTGGAGGAA	0.408000										TSP Lung(25;0.17)			29	11					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216108048	216108048	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:216108048G>A	ENST00000366943.2	-	38	7596	c.7210C>T	c.(7210-7212)Cct>Tct	p.P2404S	USH2A_ENST00000307340.3_Missense_Mutation_p.P2404S			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2404	Fibronectin type-III 10.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGGTAAAAGGAACCAGCCCA	0.398000										HNSCC(13;0.011)			43	56					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9892309	9892309	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr4:9892309C>T	ENST00000506583.1	-	11	1270	c.1053G>A	c.(1051-1053)cgG>cgA	p.R351R	SLC2A9_ENST00000309065.3_Silent_p.R351R|SLC2A9_ENST00000264784.3_Silent_p.R380R			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	380					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						GGAGGGGTCTCCGTCCCAGGT	0.522000													9	4					0	0	1	0	0
AGFG2	3268	broad.mit.edu	37	7	100153353	100153353	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:100153353C>T	ENST00000300176.4	+	6	994	c.872C>T	c.(871-873)cCt>cTt	p.P291L	AGFG2_ENST00000474713.1_3'UTR|AGFG2_ENST00000262935.4_3'UTR	NM_006076.4	NP_006067.3	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	291					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CAGCCAACTCCTGCAGGTAAA	0.507000													30	44					0	0	1	0	0
MIR520G	574484	broad.mit.edu	37	19	54225471	54225471	+	RNA	SNP	A	A	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:54225471A>T	ENST00000385064.1	+	0	52					NR_030206.1																						TGTCTGAGAAAAAACAAAGTG	0.413000													20	37					0	0	1	0	0
CLU	1191	broad.mit.edu	37	8	27461904	27461904	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:27461904C>T	ENST00000316403.10	-	6	1243	c.838G>A	c.(838-840)Gat>Aat	p.D280N	CLU_ENST00000405140.3_Missense_Mutation_p.D280N|CLU_ENST00000546343.1_Missense_Mutation_p.D291N|CLU_ENST00000560366.1_Missense_Mutation_p.D332N|CLU_ENST00000523500.1_Missense_Mutation_p.D280N			P10909	CLUS_HUMAN	clusterin	280					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		GTCCGGTCATCGTCGCCTTCT	0.517000													11	20					0	0	1	0	0
ARF5	381	broad.mit.edu	37	7	127228564	127228564	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:127228564C>T	ENST00000000233.5	+	1	166	c.12C>T	c.(10-12)acC>acT	p.T4T	GCC1_ENST00000497650.1_Intron|ARF5_ENST00000467281.1_3'UTR	NM_001662.3	NP_001653.1	P84085	ARF5_HUMAN	ADP-ribosylation factor 5	4					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			cervix(2)|kidney(1)|lung(10)|ovary(1)	14						TGGGCCTCACCGTGTCCGCGC	0.756000													6	8					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35965560	35965560	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:35965560G>A	ENST00000490799.1	-	5	935	c.582C>T	c.(580-582)tcC>tcT	p.S194S	SLC26A8_ENST00000394602.2_Silent_p.S194S|SLC26A8_ENST00000355574.2_Silent_p.S194S	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	194					cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						CCACACTCAAGGATTTATTAT	0.438000													14	33					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48604128	48604128	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr4:48604128G>A	ENST00000537810.1	-	13	1548	c.944C>T	c.(943-945)cCa>cTa	p.P315L	FRYL_ENST00000503238.1_Missense_Mutation_p.P315L|FRYL_ENST00000358350.4_Missense_Mutation_p.P315L|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000506685.1_Missense_Mutation_p.P21L|FRYL_ENST00000507711.1_Missense_Mutation_p.P315L			O94915	FRYL_HUMAN	FRY-like	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						GGTAATTAGTGGATATAAAGC	0.303000													15	19					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140419753	140419753	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:140419753G>A	ENST00000286349.3	+	5	2300	c.2109G>A	c.(2107-2109)ggG>ggA	p.G703G		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	703						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ATGGACATGGGAAGAACCGAG	0.532000													15	21					0	0	1	0	0
AIFM1	9131	broad.mit.edu	37	X	129290468	129290468	+	Silent	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chrX:129290468A>G	ENST00000287295.3	-	2	446	c.216T>C	c.(214-216)atT>atC	p.I72I	AIFM1_ENST00000346424.2_Intron|AIFM1_ENST00000535724.1_Intron|AIFM1_ENST00000319908.3_Intron	NM_001130847.3|NM_004208.3	NP_001124319.1|NP_004199.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1	72					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						ATAAGCCCACAATAAGGACTA	0.443000													60	13					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130778026	130778026	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:130778026G>A	ENST00000276708.4	-	4	1299	c.418C>T	c.(418-420)Cca>Tca	p.P140S		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	140						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						GATGGCTCTGGATCCAACAGT	0.507000													15	20					0	0	1	0	0
SPRR4	163778	broad.mit.edu	37	1	152944394	152944394	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:152944394C>G	ENST00000328051.2	+	2	77	c.28C>G	c.(28-30)Cag>Gag	p.Q10E		NM_173080.1	NP_775103.1	Q96PI1	SPRR4_HUMAN	small proline-rich protein 4	10	Gln-rich.				keratinization|peptide cross-linking	cell cortex				lung(1)|prostate(1)	2	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			gcagcggcagcagcagcagTG	0.552000													27	47					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57335829	57335829	+	Silent	SNP	G	G	A	rs148324200		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:57335829G>A	ENST00000326441.9	-	4	558	c.195C>T	c.(193-195)atC>atT	p.I65I	PEG3_ENST00000593695.1_Intron|PEG3_ENST00000594706.1_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Silent_p.I65I|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000598410.1_Intron|ZIM2_ENST00000599935.1_5'UTR|ZIM2_ENST00000391708.3_5'UTR	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	65	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCGGAGTTTGATCAGGGTCT	0.502000													28	42					0	0	1	0	0
TBC1D22A	25771	broad.mit.edu	37	22	47189461	47189461	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr22:47189461C>T	ENST00000337137.4	+	3	349	c.183C>T	c.(181-183)ttC>ttT	p.F61F	TBC1D22A_ENST00000406733.1_Silent_p.F14F|TBC1D22A_ENST00000355704.3_Silent_p.F42F|TBC1D22A_ENST00000472791.1_3'UTR|TBC1D22A_ENST00000380995.1_Silent_p.F14F|TBC1D22A_ENST00000407381.3_Silent_p.F61F	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	61						intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		TCAGCACCTTCCAGGAGTTTG	0.592000													15	31					0	0	1	0	0
LENG1	79165	broad.mit.edu	37	19	54660641	54660641	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:54660641G>A	ENST00000222224.3	-	3	621	c.435C>T	c.(433-435)gcC>gcT	p.A145A		NM_024316.1	NP_077292.1	Q96BZ8	LENG1_HUMAN	leukocyte receptor cluster (LRC) member 1	145										breast(1)|endometrium(3)|large_intestine(2)|lung(1)|ovary(1)	8	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TCTCATCTGGGGCTGGGCCGG	0.647000													39	48					0	0	1	0	0
RUVBL2	10856	broad.mit.edu	37	19	49507628	49507628	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:49507628T>A	ENST00000413176.2	+	4	1231	c.83T>A	c.(82-84)gTc>gAc	p.V28D	RUVBL2_ENST00000595090.1_Missense_Mutation_p.V73D|RUVBL2_ENST00000601968.1_Missense_Mutation_p.V28D			Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	73					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		GGTCGGGCAGTCCTTATTGCT	0.632000													29	41					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46771693	46771693	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:46771693G>A	ENST00000394809.4	-	3	1046	c.931C>T	c.(931-933)Cag>Tag	p.Q311*	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	311					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CCTGGGCACTGAGGGCCAGGC	0.657000													31	42					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113234603	113234603	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:113234603C>T	ENST00000401783.2	-	15	2936	c.2599_splice	c.e15-1	p.G867_splice	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Splice_Site_p.G867_splice|SVEP1_ENST00000374469.1_Splice_Site_p.G844_splice	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	867					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						GCCACCTGGTCCTGGATAGTC	0.483000													21	22					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	153994658	153994658	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:153994658G>A	ENST00000496811.1	-	24	2799	c.2719C>T	c.(2719-2721)Cca>Tca	p.P907S	DHX36_ENST00000329463.5_Missense_Mutation_p.P893S|DHX36_ENST00000308361.6_Missense_Mutation_p.P878S|DHX36_ENST00000544526.1_Missense_Mutation_p.P893S	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	907						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			AGACAGTATGGGGAAACCTCT	0.348000													7	21					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101020717	101020717	+	Missense_Mutation	SNP	C	C	T	rs79298856		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:101020717C>T	ENST00000360863.6	-	15	2441	c.2247G>A	c.(2245-2247)atG>atA	p.M749I	RGS22_ENST00000519421.1_5'UTR|RGS22_ENST00000523287.1_Missense_Mutation_p.M568I|RGS22_ENST00000523437.1_Missense_Mutation_p.M737I	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	749					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			GCTGTATTTTCATATAAATTT	0.403000													12	27					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48250034	48250034	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:48250034G>A	ENST00000394747.1	-	6	1291	c.942C>T	c.(940-942)ttC>ttT	p.F314F	ABCC11_ENST00000356608.2_Silent_p.F314F|ABCC11_ENST00000394748.1_Silent_p.F314F|ABCC11_ENST00000353782.5_Silent_p.F314F|ABCC11_ENST00000537808.1_Silent_p.F314F	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	314	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CCGCCAGTGGGAAAACCAGGA	0.473000													31	65					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240374523	240374523	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:240374523G>A	ENST00000319653.9	+	6	4283	c.4053G>A	c.(4051-4053)acG>acA	p.T1351T		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1351	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCTCAAAGACGAAGGCTAAAC	0.338000													29	48					0	0	1	0	0
SHCBP1	79801	broad.mit.edu	37	16	46638279	46638279	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:46638279A>T	ENST00000303383.3	-	6	1050	c.784T>A	c.(784-786)Tta>Ata	p.L262I		NM_024745.4	NP_079021.3	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	262										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				CTCAGATTTAAAAATTTCCTG	0.383000													40	47					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21901480	21901480	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:21901480G>A	ENST00000328843.6	+	70	11264	c.11233G>A	c.(11233-11235)Gtg>Atg	p.V3745M	DNAH11_ENST00000409508.3_Missense_Mutation_p.V3738M			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3745					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GGCTTTTAACGTGCTGTTCCA	0.483000									Kartagener syndrome				17	17					0	0	1	0	0
CXCR1	3577	broad.mit.edu	37	2	219028978	219028978	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:219028978G>A	ENST00000295683.2	-	2	1077	c.957C>T	c.(955-957)atC>atT	p.I319I		NM_000634.2	NP_000625.1	P25024	CXCR1_HUMAN	chemokine (C-X-C motif) receptor 1	319					dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(3)	13						GCATAGCCAGGATCTTGAGGA	0.502000													25	37					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27222846	27222846	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:27222846C>T	ENST00000230582.3	+	11	1427	c.1412C>T	c.(1411-1413)tCc>tTc	p.S471F	PRSS16_ENST00000421826.2_Missense_Mutation_p.S214F|PRSS16_ENST00000377456.2_3'UTR	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	471					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CGCACTGGCTCCCACTGCTTG	0.532000													48	123					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	167020590	167020590	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr4:167020590G>A	ENST00000061240.2	+	20	3465	c.2818G>A	c.(2818-2820)Gaa>Aaa	p.E940K	TLL1_ENST00000507499.1_Missense_Mutation_p.E963K	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	940	CUB 5.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGAAGTGGAGGAAGAAGCAGA	0.468000													41	31					0	0	1	0	0
LCN2	3934	broad.mit.edu	37	9	130915390	130915390	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:130915390G>A	ENST00000373017.1	+	7	826	c.589G>A	c.(589-591)Gac>Aac	p.D197N	LCN2_ENST00000277480.2_Missense_Mutation_p.D197N|LCN2_ENST00000372998.1_Missense_Mutation_p.D199N|LCN2_ENST00000470902.1_3'UTR|LCN2_ENST00000373013.2_Missense_Mutation_p.D199N			P80188	NGAL_HUMAN	lipocalin 2	197					apoptosis|innate immune response|regulation of apoptosis|siderophore transport		iron ion binding|transporter activity			central_nervous_system(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	8						CCAGTGTATCGACGGCTGAGT	0.607000													48	78					0	0	1	0	0
SH3RF3	344558	broad.mit.edu	37	2	109964334	109964334	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:109964334C>T	ENST00000309415.6	+	2	778	c.778C>T	c.(778-780)Cag>Tag	p.Q260*		NM_001099289.1	NP_001092759.1	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	260	SH3 2.						zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(5)|ovary(2)	18						CGCCCCGCCCCAGGGAAAAGC	0.597000													5	4					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27840950	27840950	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr21:27840950C>T	ENST00000299340.4	-	4	678	c.334_splice	c.e4-1	p.G112_splice	AP001596.6_ENST00000444306.1_RNA|AP001596.6_ENST00000429340.1_RNA|AP001596.6_ENST00000421771.1_RNA|CYYR1_ENST00000435845.2_3'UTR|AP001597.1_ENST00000357401.3_RNA|AP001597.1_ENST00000414486.1_RNA	NM_052954.2	NP_443186.1	Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	112						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						GGGTGGTGGTCCTGCTGAAAA	0.522000													19	22					0	0	1	0	0
GDPD5	81544	broad.mit.edu	37	11	75154313	75154313	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:75154313G>A	ENST00000526177.1	-	7	2280	c.402C>T	c.(400-402)ttC>ttT	p.F134F	GDPD5_ENST00000529721.1_Silent_p.F272F|GDPD5_ENST00000533805.1_Silent_p.F27F|GDPD5_ENST00000443276.2_3'UTR|GDPD5_ENST00000336898.3_Silent_p.F272F|GDPD5_ENST00000533784.1_Silent_p.F153F|GDPD5_ENST00000376282.3_Silent_p.F153F			Q8WTR4	GDPD5_HUMAN	glycerophosphodiester phosphodiesterase domain containing 5	272					glycerol metabolic process|lipid metabolic process|nervous system development	endomembrane system|growth cone|integral to membrane|perinuclear region of cytoplasm	glycerophosphodiester phosphodiesterase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|skin(2)	20						CATGCATGAGGAAGGGCACGC	0.657000													9	10					0	0	1	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107040048	107040048	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:107040048G>A	ENST00000369063.3	-	6	1262	c.797C>T	c.(796-798)tCc>tTc	p.S266F	RTN4IP1_ENST00000539449.1_Intron	NM_032730.4	NP_116119.2	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	266						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		CGGTTTTAAGGATTTCAACTG	0.428000													23	48					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47847973	47847973	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:47847973C>T	ENST00000289672.2	-	52	7749	c.7699G>A	c.(7699-7701)Gga>Aga	p.G2567R	C7orf69_ENST00000418326.2_Intron|C7orf69_ENST00000258776.4_Intron	NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2567					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AGGCTCACTCCAACCACGGAG	0.517000													9	20					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174784	63174784	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr14:63174784C>T	ENST00000322893.7	-	11	2677	c.2409G>A	c.(2407-2409)atG>atA	p.M803I	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	803					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTCCATTCTTCATTCTTATTG	0.453000													26	47					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15711345	15711345	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:15711345G>A	ENST00000396368.3	-	14	2974	c.2768C>T	c.(2767-2769)aCg>aTg	p.T923M	KIAA0430_ENST00000602337.1_Missense_Mutation_p.T920M|KIAA0430_ENST00000551742.1_Missense_Mutation_p.T923M|KIAA0430_ENST00000540441.2_Missense_Mutation_p.T758M|KIAA0430_ENST00000344181.3_Missense_Mutation_p.T565M|KIAA0430_ENST00000548025.1_Missense_Mutation_p.T920M	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	922						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						GATTGCGACCGTGTCTGTTAA	0.493000													13	33					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31852256	31852256	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:31852256G>A	ENST00000395728.3	-	20	2854	c.2855C>T	c.(2854-2856)tCc>tTc	p.S952F	EHMT2_ENST00000375528.4_Missense_Mutation_p.S918F|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375530.4_Missense_Mutation_p.S861F|EHMT2_ENST00000375537.4_Missense_Mutation_p.S895F			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	895					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						CCACACGTCGGAGCGCTCGGG	0.612000													47	145					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27509122	27509122	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:27509122G>A	ENST00000356183.4	-	14	2201	c.2186C>T	c.(2185-2187)cCa>cTa	p.P729L	GTF3C1_ENST00000561623.1_Missense_Mutation_p.P729L	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	729						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						TTGGGGCACTGGAGGCTGGGA	0.478000													18	22					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16263525	16263525	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:16263525G>A	ENST00000205557.7	-	22	3002	c.2973C>T	c.(2971-2973)ttC>ttT	p.F991F		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	991	ABC transmembrane type-1 2.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CGAGGAGCCCGAAGATCCCGC	0.667000													6	5					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72984673	72984673	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:72984673G>A	ENST00000268489.5	-	3	3583	c.2911C>T	c.(2911-2913)Ctg>Ttg	p.L971L	ZFHX3_ENST00000397992.5_Silent_p.L57L	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	971					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TCCTCCGACAGGCTGCGCTCC	0.602000													8	18					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40901474	40901474	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:40901474A>C	ENST00000324001.7	-	7	3055	c.2785T>G	c.(2785-2787)Tcc>Gcc	p.S929A	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	929					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGAACTTGGAAGAGGGCTTG	0.547000													37	68					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110839568	110839568	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr13:110839568G>A	ENST00000375820.4	-	25	1766	c.1645C>T	c.(1645-1647)Cca>Tca	p.P549S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	549	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGCTGTCCTGGAAAGCCTGGG	0.592000													34	41					0	0	1	0	0
DYNAP	284254	broad.mit.edu	37	18	52265165	52265165	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr18:52265165C>T	ENST00000321600.1	+	3	468	c.422C>T	c.(421-423)tCg>tTg	p.S141L	DYNAP_ENST00000585973.1_Missense_Mutation_p.S89L	NM_173629.1	NP_775900.1			dynactin associated protein																		AACAAAGGATCGGCCAATTCC	0.448000													15	32					0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132905786	132905786	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:132905786C>T	ENST00000409867.1	-	6	944	c.695G>A	c.(694-696)gGa>gAa	p.G232E	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like											endometrium(1)|kidney(3)	4						ATCAGGTGTTCCTTCAGATGT	0.443000													4	4					0	0	1	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342620	94342620	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:94342620C>T	ENST00000436063.2	-	2	928	c.871G>A	c.(871-873)Gaa>Aaa	p.E291K	DNTTIP2_ENST00000460191.1_5'UTR	NM_014597.4	NP_055412.2	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal, interacting protein 2	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	38		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TGTTTTGTTTCTTTAAGAGAT	0.338000													13	5					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72889537	72889537	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:72889537G>A	ENST00000264839.7	+	5	731	c.731G>A	c.(730-732)gGg>gAg	p.G244E	RIMS1_ENST00000348717.5_Missense_Mutation_p.G244E|RIMS1_ENST00000522291.1_Missense_Mutation_p.G244E|RIMS1_ENST00000491071.2_Missense_Mutation_p.G244E|RIMS1_ENST00000521978.1_Missense_Mutation_p.G244E|RIMS1_ENST00000520567.1_Missense_Mutation_p.G244E|RIMS1_ENST00000518273.1_Missense_Mutation_p.G244E|RIMS1_ENST00000517960.1_Missense_Mutation_p.G244E			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	244					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AGGAGCAAAGGGGCTGAGCCC	0.587000													4	13					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41272544	41272544	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:41272544G>A	ENST00000361937.3	-	36	4972	c.4548C>T	c.(4546-4548)tcC>tcT	p.S1516S	INO80_ENST00000401393.3_Silent_p.S1516S			Q9ULG1	INO80_HUMAN	INO80 complex subunit	1516	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TGCTCAAAGGGGAACTCAAAG	0.557000													15	27					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150718678	150718678	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:150718678G>A	ENST00000335244.4	-	5	597	c.468C>T	c.(466-468)atC>atT	p.I156I	SLC36A2_ENST00000521967.1_Silent_p.I156I	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	156				I -> N (in Ref. 1; AAO11788).	cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAAGTTGGGTGATAATAAGGA	0.398000													36	16					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154705564	154705564	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:154705564G>T	ENST00000271915.3	-	4	1820	c.1505C>A	c.(1504-1506)tCc>tAc	p.S502Y	KCNN3_ENST00000361147.4_Missense_Mutation_p.S197Y|KCNN3_ENST00000358505.2_Missense_Mutation_p.S189Y	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	507						integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GAATGTGATGGAGATGAGCCA	0.517000													12	30					4.36969e-10	4.49685e-10	1	1	0
ATP1A3	478	broad.mit.edu	37	19	42490372	42490372	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:42490372C>T	ENST00000545399.1	-	5	559	c.406G>A	c.(406-408)Ggc>Agc	p.G136S	ATP1A3_ENST00000302102.5_Missense_Mutation_p.G123S|ATP1A3_ENST00000602133.1_Missense_Mutation_p.G93S|ATP1A3_ENST00000543770.1_Missense_Mutation_p.G134S	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	123					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						AGCACGATGCCCAGGTACAGC	0.597000													12	29					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78195378	78195378	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:78195378G>A	ENST00000361193.3	+	3	299	c.19G>A	c.(19-21)Gcg>Acg	p.A7T	SLC26A11_ENST00000546047.2_Missense_Mutation_p.A7T|SLC26A11_ENST00000411502.3_Missense_Mutation_p.A7T|SLC26A11_ENST00000572725.1_Missense_Mutation_p.A7T|SLC26A11_ENST00000571602.1_3'UTR	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	7						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TTCGGTGACGGCGCTGGGTCA	0.682000													13	8					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201186515	201186515	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:201186515C>T	ENST00000335211.4	+	17	9826	c.9696C>T	c.(9694-9696)atC>atT	p.I3232I	IGFN1_ENST00000295591.8_Silent_p.I392I	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GCGCCCACATCCTGGGCTACC	0.657000													27	40					0	0	1	0	0
MS4A15	219995	broad.mit.edu	37	11	60531280	60531280	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:60531280C>T	ENST00000405633.3	+	2	153	c.74C>T	c.(73-75)cCt>cTt	p.P25L	MS4A15_ENST00000528170.1_Missense_Mutation_p.P25L|MS4A15_ENST00000337911.4_Intron	NM_001098835.1	NP_001092305.1	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member 15	25						integral to membrane	receptor activity			breast(1)|large_intestine(2)|lung(3)	6						CTCTGCCCACCTCCGGCCATT	0.597000													50	63					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70964892	70964892	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:70964892G>A	ENST00000334414.6	-	13	3328	c.3284C>T	c.(3283-3285)tCc>tTc	p.S1095F	PTPRB_ENST00000550857.1_Missense_Mutation_p.S787F|PTPRB_ENST00000261266.5_Missense_Mutation_p.S877F|PTPRB_ENST00000451516.2_Missense_Mutation_p.S787F|PTPRB_ENST00000550358.1_Missense_Mutation_p.S1007F|PTPRB_ENST00000551525.1_Missense_Mutation_p.S1094F|PTPRB_ENST00000538708.1_Missense_Mutation_p.S877F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	877	Fibronectin type-III 13.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.S1095F(1)|p.S877F(1)		breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGGTGTTAGGGAAGTAAATCG	0.448000													13	25					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369655	56369655	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:56369655C>T	ENST00000301295.6	+	3	1318	c.896C>T	c.(895-897)cCc>cTc	p.P299L	NLRP4_ENST00000346986.5_Missense_Mutation_p.P299L|NLRP4_ENST00000587891.1_Missense_Mutation_p.P224L	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	299	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ATCTACCAGCCCCGGGGATTC	0.507000													19	32					0	0	1	0	0
CWC25	54883	broad.mit.edu	37	17	36965995	36965995	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:36965995G>A	ENST00000225428.4	-	6	947	c.650C>T	c.(649-651)tCc>tTc	p.S217F	CWC25_ENST00000536127.1_Missense_Mutation_p.S154F	NM_017748.3	NP_060218.1	Q9NXE8	CWC25_HUMAN	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	217										central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	14						AACAGGGGAGGAATTTGCCAT	0.408000													5	16					0	0	1	0	0
ANKRD44	91526	broad.mit.edu	37	2	197866501	197866501	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:197866501G>A	ENST00000328737.2	-	22	2412	c.2336C>T	c.(2335-2337)cCc>cTc	p.P779L	ANKRD44_ENST00000450567.1_Missense_Mutation_p.P779L|ANKRD44_ENST00000337207.5_Missense_Mutation_p.P779L|ANKRD44_ENST00000282272.8_Missense_Mutation_p.P796L			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	804							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGGAGTAAAGGGATTACCGAT	0.338000													16	32					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28991184	28991184	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr18:28991184C>T	ENST00000359747.4	+	14	2214	c.2185C>T	c.(2185-2187)Ccc>Tcc	p.P729S	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Intron|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	710					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCAACATCCTCCCTTTTCAGA	0.607000													15	31					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113146050	113146050	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:113146050G>A	ENST00000316851.7	+	18	2488	c.2488G>A	c.(2488-2490)Gaa>Aaa	p.E830K	NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	840					axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AGCGCCAGCCGAAGTCAAGAC	0.522000													7	12					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17111250	17111250	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:17111250C>T	ENST00000443236.1	-	10	1013	c.982G>A	c.(982-984)Gga>Aga	p.G328R	CPAMD8_ENST00000388925.4_Missense_Mutation_p.G281R	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	281						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						ACAGGGCGTCCCACCTCGTGG	0.498000													11	15					0	0	1	0	0
SH3RF3	344558	broad.mit.edu	37	2	109964176	109964176	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:109964176G>A	ENST00000309415.6	+	2	620	c.620G>A	c.(619-621)gGg>gAg	p.G207E		NM_001099289.1	NP_001092759.1	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	207	SH3 1.						zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(5)|ovary(2)	18						AGCTACGAGGGGAAGGAACCT	0.597000													8	11					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81112815	81112815	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:81112815C>T	ENST00000228644.3	+	3	905	c.753C>T	c.(751-753)atC>atT	p.I251I		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	251					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						CCAGGCTTATCTATCATGTGC	0.483000													14	23					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33876366	33876366	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:33876366C>T	ENST00000374408.3	-	3	800	c.704G>A	c.(703-705)tGt>tAt	p.C235Y		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	235										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TGTGTCCCCACACGTGCTCCG	0.602000													8	23					0	0	1	0	0
SCEL	8796	broad.mit.edu	37	13	78177213	78177213	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr13:78177213G>A	ENST00000535157.1	+	17	1144	c.974G>A	c.(973-975)aGt>aAt	p.S325N	SCEL-AS1_ENST00000456280.2_RNA|SCEL_ENST00000469982.1_Intron|SCEL-AS1_ENST00000457528.2_RNA|SCEL_ENST00000377246.3_Missense_Mutation_p.S327N|SCEL_ENST00000349847.3_Missense_Mutation_p.S347N	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	347	16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		TTTTAAAGAAGTGAAGACCTT	0.289000													12	10					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117175335	117175335	+	Missense_Mutation	SNP	C	C	T	rs121908803		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:117175335C>T	ENST00000003084.6	+	6	745	c.613C>T	c.(613-615)Cct>Tct	p.P205S	CFTR_ENST00000454343.1_Missense_Mutation_p.P205S	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	205	ABC transmembrane type-1 1.		P -> S (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding	p.P205S(1)		NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GTGGATCGCTCCTTTGCAAGT	0.473000									Cystic Fibrosis				48	72					0	0	1	0	0
ZNF275	10838	broad.mit.edu	37	X	152613170	152613170	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chrX:152613170C>T	ENST00000421401.3	+	4	1204	c.1027C>T	c.(1027-1029)Cac>Tac	p.H343Y	ZNF275_ENST00000370251.2_Intron|ZNF275_ENST00000370249.2_Missense_Mutation_p.H290Y|ZNF275_ENST00000440091.1_Missense_Mutation_p.H373Y	NM_001080485.3	NP_001073954.3	A6NFS0	A6NFS0_HUMAN	zinc finger protein 275	259						intracellular	nucleic acid binding|zinc ion binding			endometrium(5)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGCACGCATCCACAGTGGCGA	0.682000													12	6					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139180190	139180190	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:139180190C>T	ENST00000395297.1	-	12	1376	c.1206G>A	c.(1204-1206)tgG>tgA	p.W402*		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	402										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GCAGGGTGTTCCAATCGCCGT	0.552000										HNSCC(54;0.14)			35	58					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53741069	53741069	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:53741069G>A	ENST00000333952.4	-	5	1076	c.911C>T	c.(910-912)tCg>tTg	p.S304L	ZNF677_ENST00000598513.1_Missense_Mutation_p.S304L			Q86XU0	ZN677_HUMAN	zinc finger protein 677	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		AGTGAGGTTCGAACACTGGTT	0.403000													19	32					0	0	1	0	0
C19orf55	148137	broad.mit.edu	37	19	36256065	36256065	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:36256065C>T	ENST00000544099.1	+	7	820	c.757C>T	c.(757-759)Ccc>Tcc	p.P253S	C19orf55_ENST00000396908.4_Missense_Mutation_p.P253S			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	253										cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGCCTTGGCCCCAGGGCACC	0.617000													12	24					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103703679	103703679	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr13:103703679C>T	ENST00000245312.3	-	4	1285	c.689G>A	c.(688-690)gGa>gAa	p.G230E		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	230					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AAATATTGTTCCTATAATCCA	0.493000													22	33					0	0	1	0	0
IQCE	23288	broad.mit.edu	37	7	2613102	2613102	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:2613102G>A	ENST00000402050.2	+	6	629	c.445G>A	c.(445-447)Gag>Aag	p.E149K	IQCE_ENST00000438376.2_Missense_Mutation_p.E133K|IQCE_ENST00000404984.1_Missense_Mutation_p.E98K|IQCE_ENST00000325979.7_Missense_Mutation_p.E84K	NM_001100390.1|NM_152558.3	NP_001093860.1|NP_689771.3	Q6IPM2	IQCE_HUMAN	IQ motif containing E	149										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		TATGTATGACGAGATTATTGA	0.358000													12	20					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79952424	79952424	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:79952424C>T	ENST00000360280.3	+	47	6609	c.6349C>T	c.(6349-6351)Ctt>Ttt	p.L2117F	VPS13A_ENST00000376636.3_Missense_Mutation_p.L2078F|VPS13A_ENST00000357409.5_Missense_Mutation_p.L2117F|VPS13A_ENST00000376634.4_Missense_Mutation_p.L2117F	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	2117					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CCGAAATCTTCTTCCTTACAA	0.328000													31	15					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112024188	112024188	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chrX:112024188G>A	ENST00000371959.3	-	9	2398	c.2399C>T	c.(2398-2400)tCc>tTc	p.S800F	AMOT_ENST00000371962.1_Missense_Mutation_p.S568F|AMOT_ENST00000371958.1_Missense_Mutation_p.S568F|AMOT_ENST00000304758.1_Missense_Mutation_p.S391F|AMOT_ENST00000524145.1_Missense_Mutation_p.S800F	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	800					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						GGATGAGTGGGAGAGCAAGCC	0.542000													59	23					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118320038	118320038	+	Splice_Site	SNP	T	T	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr10:118320038T>G	ENST00000369221.2	+	11	1197		c.e11+2			NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase						lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AATTTTCAAGTGAGTAAAATA	0.393000													8	4					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2118669	2118669	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:2118669G>A	ENST00000355272.6	-	15	1850	c.1644C>T	c.(1642-1644)gcC>gcT	p.A548A	AP3D1_ENST00000356926.4_Silent_p.A457A|AP3D1_ENST00000350812.6_Silent_p.A379A|AP3D1_ENST00000345016.5_Silent_p.A548A	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	548					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGGTGACGGCCTGAGCGC	0.647000													18	21					0	0	1	0	0
ABCC4	10257	broad.mit.edu	37	13	95727797	95727797	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr13:95727797G>A	ENST00000376887.4	-	22	2809	c.2695C>T	c.(2695-2697)Cca>Tca	p.P899S	ABCC4_ENST00000412704.1_Missense_Mutation_p.P852S	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	899	ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GAAAACACTGGACTCCGAGCT	0.532000													25	30					0	0	1	0	0
INPP5K	51763	broad.mit.edu	37	17	1416798	1416798	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:1416798G>A	ENST00000421807.2	-	3	598	c.210C>T	c.(208-210)gaC>gaT	p.D70D	INPP5K_ENST00000542125.1_Silent_p.D70D|INPP5K_ENST00000406424.4_5'UTR|INPP5K_ENST00000320345.6_5'UTR|INPP5K_ENST00000397335.3_Intron	NM_016532.3	NP_057616.2	Q9BT40	INP5K_HUMAN	inositol polyphosphate-5-phosphatase K	70	Catalytic (Potential).				actin cytoskeleton organization	cytosol|endoplasmic reticulum|membrane fraction|neuron projection|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol bisphosphate phosphatase activity|inositol trisphosphate phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|lipid phosphatase activity|protein binding			endometrium(1)|large_intestine(7)|lung(3)|skin(1)	12						TGCTCCACGAGTCATTAAAGG	0.507000													40	67					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64168143	64168143	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:64168143G>A	ENST00000395391.1	+	4	2836	c.1461G>A	c.(1459-1461)aaG>aaA	p.K487K	ZNF107_ENST00000344930.3_Silent_p.K487K|ZNF107_ENST00000423627.1_Silent_p.K487K			Q9UII5	ZN107_HUMAN	zinc finger protein 107	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CTAAACATAAGAGAATTCATA	0.333000													4	6					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983875	97983875	+	Silent	SNP	G	G	A	rs146320551		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:97983875G>A	ENST00000383696.2	+	1	788	c.747G>A	c.(745-747)ggG>ggA	p.G249G	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G249G(1)		cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CTATCAAAGGGATACGAAAAG	0.388000													13	22					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102954	168102954	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:168102954A>C	ENST00000409195.1	+	9	5141	c.5052A>C	c.(5050-5052)aaA>aaC	p.K1684N	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.K1684N|XIRP2_ENST00000409273.1_Missense_Mutation_p.K1462N|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1509					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAGATGAAAAAGGAGATATTA	0.353000													12	15					0	0	1	0	0
OR7G3	390883	broad.mit.edu	37	19	9237504	9237504	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:9237504C>T	ENST00000305444.2	-	1	122	c.123G>A	c.(121-123)ggG>ggA	p.G41G		NM_001001958.1	NP_001001958.1	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G, member 3	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	15						TGAGCAGGTTCCCCAGCATTG	0.542000													17	26					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46312213	46312213	+	Missense_Mutation	SNP	G	G	A	rs138677063		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr4:46312213G>A	ENST00000510861.1	-	6	709	c.536C>T	c.(535-537)tCa>tTa	p.S179L	GABRA2_ENST00000540012.1_Missense_Mutation_p.S124L|GABRA2_ENST00000514090.1_Missense_Mutation_p.S179L|GABRA2_ENST00000507069.1_Missense_Mutation_p.S179L|GABRA2_ENST00000356504.1_Missense_Mutation_p.S179L|GABRA2_ENST00000515082.1_Missense_Mutation_p.S179L|GABRA2_ENST00000381620.4_Missense_Mutation_p.S179L			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	179					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.S179L(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGAGGACATGAATGAGCATC	0.388000													30	21					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10382201	10382201	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:10382201G>A	ENST00000397077.1	-	19	3545	c.2970C>T	c.(2968-2970)atC>atT	p.I990I	ATP2B2_ENST00000383800.4_Silent_p.I990I|ATP2B2_ENST00000360273.2_Silent_p.I1035I|ATP2B2_ENST00000352432.4_Silent_p.I1035I|ATP2B2_ENST00000343816.4_Silent_p.I1021I			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	1035					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						TGCCCAGCACGATGGTGCAGA	0.627000													35	46					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48389950	48389950	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr10:48389950C>T	ENST00000224600.4	-	1	1041	c.928G>A	c.(928-930)Gag>Aag	p.E310K		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	310	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	AGGGCCTGCTCGGCCGGAGTC	0.677000													6	1					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764978	77764978	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:77764978G>A	ENST00000521891.2	+	10	6269	c.5821G>A	c.(5821-5823)Gaa>Aaa	p.E1941K	ZFHX4_ENST00000050961.6_Missense_Mutation_p.E1896K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E1896K|ZFHX4_ENST00000518282.1_Missense_Mutation_p.E1915K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1896						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGGTGAAGGCGAAAACACTGA	0.383000										HNSCC(33;0.089)			8	20					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676339	123676339	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:123676339G>A	ENST00000309154.2	-	1	756	c.719C>T	c.(718-720)tCt>tTt	p.S240F		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		AGTGATGTGAGAAGCACAGGT	0.507000													7	19					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109690823	109690823	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:109690823C>T	ENST00000338432.7	+	43	6024	c.5905C>T	c.(5905-5907)Ctg>Ttg	p.L1969L	ACACB_ENST00000543201.1_Silent_p.L635L|ACACB_ENST00000377848.3_Silent_p.L1969L|ACACB_ENST00000377854.5_Silent_p.L1899L			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1969	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AAAGCAGGTCCTGGGAAGAGA	0.512000													39	58					0	0	1	0	0
DOK6	220164	broad.mit.edu	37	18	67231792	67231792	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr18:67231792C>T	ENST00000382713.5	+	2	326	c.136C>T	c.(136-138)Cca>Tca	p.P46S	RP11-465I4.2_ENST00000583991.1_RNA	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	46	PH.						insulin receptor binding	p.P46S(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				AGAAAAATTTCCAGATGAAAA	0.418000													11	19					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111956585	111956585	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:111956585G>A	ENST00000374566.3	-	21	2655	c.2138C>T	c.(2137-2139)tCc>tTc	p.S713F		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	713						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CAGCGGCACGGAGACTTGTGT	0.612000													29	65					0	0	1	0	0
IHH	3549	broad.mit.edu	37	2	219925171	219925171	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:219925171G>A	ENST00000295731.5	-	1	18	c.19C>T	c.(19-21)Cgg>Tgg	p.R7W		NM_002181.3	NP_002172.2	Q14623	IHH_HUMAN	indian hedgehog	7					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGTCGGGGCCGGAGCCGGGCG	0.781000													5	10					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10091972	10091972	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:10091972G>A	ENST00000324907.9	+	1	146	c.10G>A	c.(10-12)Gag>Aag	p.E4K	GRHL1_ENST00000405379.2_Intron|GRHL1_ENST00000324883.5_5'UTR	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	4	Transcription activation.				cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		GATGACACAGGAGTACGACAA	0.751000													8	16					0	0	1	0	0
CCIN	881	broad.mit.edu	37	9	36169648	36169648	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:36169648C>T	ENST00000335119.2	+	1	260	c.149C>T	c.(148-150)tCc>tTc	p.S50F		NM_005893.2	NP_005884.2	Q13939	CALI_HUMAN	calicin	50	BTB.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			breast(3)|endometrium(2)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(4)	21			STAD - Stomach adenocarcinoma(86;0.228)			GCTGCTGTCTCCCCACTGGTG	0.532000													19	10					0	0	1	0	0
FAM177B	400823	broad.mit.edu	37	1	222919901	222919901	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:222919901G>A	ENST00000445590.2	+	3	280	c.14G>A	c.(13-15)gGt>gAt	p.G5D	FAM177B_ENST00000360827.2_Missense_Mutation_p.G5D	NM_207468.2	NP_997351.2	A6PVY3	F177B_HUMAN	family with sequence similarity 177, member B	5										breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	8						GAGATTGACGGTTTCCAGCAG	0.383000													13	23					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130774	45130774	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:45130774C>T	ENST00000457685.2	-	6	2413	c.1090G>A	c.(1090-1092)Gaa>Aaa	p.E364K	ZNF334_ENST00000593880.1_Missense_Mutation_p.E425K|ZNF334_ENST00000347606.4_Missense_Mutation_p.E402K			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				TAGGGTTTTTCCCCTGTGTGA	0.433000													36	65					0	0	1	0	0
RP11-166D19.1	0	broad.mit.edu	37	11	121970470	121970470	+	RNA	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:121970470G>A	ENST00000531381.1	-	0	732				MIR125B1_ENST00000385236.1_RNA																							GCAAAAGCACGACTCGCAGCT	0.413000													10	20					0	0	1	0	0
C19orf55	148137	broad.mit.edu	37	19	36256066	36256066	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:36256066C>T	ENST00000544099.1	+	7	821	c.758C>T	c.(757-759)cCc>cTc	p.P253L	C19orf55_ENST00000396908.4_Missense_Mutation_p.P253L			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	253										cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCCTTGGCCCCAGGGCACCC	0.617000													13	22					0	0	1	0	0
ALDH1A1	216	broad.mit.edu	37	9	75526907	75526907	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:75526907A>C	ENST00000297785.3	-	10	1221	c.1167T>G	c.(1165-1167)aaT>aaG	p.N389K		NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	389					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CATCTGTAACATTAGAGAACA	0.453000													30	13					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22255619	22255619	+	Silent	SNP	G	G	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:22255619G>C	ENST00000594947.1	+	2	156	c.12G>C	c.(10-12)ctG>ctC	p.L4L	ZNF257_ENST00000600162.1_Silent_p.L4L	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	4	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGGGACCACTGACAATTAGGG	0.408000													32	51					0	0	1	0	0
ZBTB32	27033	broad.mit.edu	37	19	36205964	36205964	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:36205964G>A	ENST00000392197.2	+	3	754	c.436G>A	c.(436-438)Gga>Aga	p.G146R	ZBTB32_ENST00000262630.3_Missense_Mutation_p.G146R			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	146					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGGGACCCTGGAGAGAAGCA	0.547000													13	18					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114269985	114269985	+	Silent	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:114269985A>G	ENST00000393500.3	+	11	1117	c.297A>G	c.(295-297)caA>caG	p.Q99Q	FOXP2_ENST00000360232.4_Silent_p.Q174Q|FOXP2_ENST00000393494.2_Silent_p.Q174Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000393491.3_Silent_p.Q82Q|FOXP2_ENST00000393489.3_Silent_p.Q82Q|FOXP2_ENST00000378237.3_Silent_p.Q174Q|FOXP2_ENST00000393498.2_Silent_p.Q154Q|FOXP2_ENST00000408937.3_Silent_p.Q199Q|FOXP2_ENST00000350908.4_Silent_p.Q174Q|FOXP2_ENST00000390668.3_Silent_p.Q198Q|FOXP2_ENST00000403559.4_Silent_p.Q191Q			O15409	FOXP2_HUMAN	forkhead box P2	174	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q199Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						aacaacaacaacagcagcaac	0.502000													3	57					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271743	22271743	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:22271743G>A	ENST00000594947.1	+	4	1335	c.1191G>A	c.(1189-1191)gaG>gaA	p.E397E		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATACTAGAGAGAAGGCCTACA	0.373000													5	4					0	0	1	0	0
GCAT	23464	broad.mit.edu	37	22	38211173	38211173	+	Missense_Mutation	SNP	C	C	T	rs142152598		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr22:38211173C>T	ENST00000323205.6	+	5	758	c.695C>T	c.(694-696)tCc>tTc	p.S232F	GCAT_ENST00000248924.6_Missense_Mutation_p.S206F	NM_001171690.1	NP_001165161.1	O75600	KBL_HUMAN	glycine C-acetyltransferase	206					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups	p.S206F(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	12	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GGGGCCTTTTCCATGGATGGC	0.587000													15	24					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839084	15839084	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:15839084C>T	ENST00000305899.3	+	1	251	c.231C>T	c.(229-231)atC>atT	p.I77I		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CCGTGGCCATCATCCCGCGCA	0.622000													20	36					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125261910	125261910	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:125261910C>T	ENST00000431078.1	+	8	1465	c.1101C>T	c.(1099-1101)ccC>ccT	p.P367P		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	367	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.P367Q(1)|p.P367P(1)		NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGATTGTGCCCATCACATTTG	0.463000													29	38					0	0	1	0	0
RUNDC1	146923	broad.mit.edu	37	17	41143231	41143231	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:41143231C>T	ENST00000361677.1	+	5	1352	c.1340C>T	c.(1339-1341)cCa>cTa	p.P447L		NM_173079.2	NP_775102.2	Q96C34	RUND1_HUMAN	RUN domain containing 1	447	RUN.									breast(1)|large_intestine(2)|lung(4)|prostate(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GCCTCCTCCCCAGGGATGAGC	0.582000													17	15					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921025	247921025	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:247921025G>A	ENST00000408896.2	-	1	957	c.684C>T	c.(682-684)atC>atT	p.I228I		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GAGTAGAGGTGATCTTCAGAA	0.493000													13	11					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113357227	113357227	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:113357227G>A	ENST00000202917.5	+	6	1335	c.1072G>A	c.(1072-1074)Gat>Aat	p.D358N	RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000445409.2_Intron|OAS1_ENST00000551241.1_Intron	NM_016816.2	NP_058132.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	358					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding	p.D358N(2)		cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						TGAGACCGACGATCCCAGGAG	0.507000													20	32					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44578685	44578685	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:44578685G>A	ENST00000289547.4	-	2	1366	c.1311C>T	c.(1309-1311)gaC>gaT	p.D437D	NPC1L1_ENST00000423141.1_Silent_p.D437D|NPC1L1_ENST00000381160.3_Silent_p.D437D|NPC1L1_ENST00000546276.1_Silent_p.D437D	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	437					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GCAAGTCCAGGTCCAGGATTC	0.597000													15	25					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71478068	71478068	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:71478068G>A	ENST00000370924.4	-	2	1227	c.997C>T	c.(997-999)Cgc>Tgc	p.R333C	PTGER3_ENST00000370931.3_Missense_Mutation_p.R333C|PTGER3_ENST00000306666.5_Missense_Mutation_p.R333C|PTGER3_ENST00000351052.5_Missense_Mutation_p.R333C|PTGER3_ENST00000356595.4_Missense_Mutation_p.R333C|PTGER3_ENST00000354608.5_Missense_Mutation_p.R333C|PTGER3_ENST00000460330.1_Missense_Mutation_p.R333C|PTGER3_ENST00000370932.2_Missense_Mutation_p.R333C|PTGER3_ENST00000414819.1_Missense_Mutation_p.R333C	NM_198715.2	NP_942008.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	333					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity	p.R333S(1)		endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	GAAGCCAGGCGAACAGCTATT	0.428000													12	8					0	0	1	0	0
SEPT3	55964	broad.mit.edu	37	22	42388763	42388763	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr22:42388763C>T	ENST00000396425.3	+	8	992	c.861C>T	c.(859-861)atC>atT	p.I287I	SEPT3_ENST00000328414.8_3'UTR|SEPT3_ENST00000396426.3_Silent_p.I287I|SEPT3_ENST00000291236.11_Silent_p.I223I|SEPT3_ENST00000406029.1_Silent_p.I223I	NM_019106.5	NP_061979.3	Q9UH03	SEPT3_HUMAN	septin 3	287					cell cycle|cytokinesis	cell junction|septin complex	GTP binding			breast(1)|kidney(3)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17						GGGGGATCATCGAAGGTAATT	0.483000													5	2					0	0	1	0	0
GPR141	353345	broad.mit.edu	37	7	37780713	37780713	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:37780713C>T	ENST00000447769.1	+	4	1007	c.718C>T	c.(718-720)Ccc>Tcc	p.P240S	GPR141_ENST00000334425.1_Missense_Mutation_p.P240S|GPR141_ENST00000461610.1_Intron|EPDR1_ENST00000476620.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	240						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTGTTTCCTTCCCTACCAGTT	0.418000													24	56					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067346	9067346	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:9067346G>A	ENST00000397910.4	-	3	20303	c.20100C>T	c.(20098-20100)tcC>tcT	p.S6700S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6702	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCCTGGAATGGATGTTCTTC	0.483000													60	83					0	0	1	0	0
HTR7P1	93164	broad.mit.edu	37	12	13155476	13155476	+	RNA	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:13155476C>T	ENST00000543321.1	+	0	31				HTR7P1_ENST00000535469.1_RNA																							GACAGCCAGACCCTTCTGTCT	0.527000													12	18					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133946923	133946923	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:133946923C>T	ENST00000361069.4	+	18	3255	c.3122C>T	c.(3121-3123)tCc>tTc	p.S1041F	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	1041	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CTCCAAGGGTCCGACTGTGGC	0.607000													28	46					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961871	73961871	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chrX:73961871T>A	ENST00000373468.1	-	3	3172	c.2521A>T	c.(2521-2523)Aat>Tat	p.N841Y	KIAA2022_ENST00000055682.5_Missense_Mutation_p.N841Y			Q5QGS0	K2022_HUMAN	KIAA2022	841					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						CTGCCTTCATTTTGCTCTGGA	0.483000													26	7					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648256	112648256	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:112648256G>A	ENST00000471858.1	-	3	464	c.232C>T	c.(232-234)Ctg>Ttg	p.L78L	CD200R1_ENST00000490004.1_Silent_p.L78L|CD200R1_ENST00000295863.4_Silent_p.L56L|CD200R1_ENST00000440122.2_Silent_p.L101L|CD200R1_ENST00000308611.3_Silent_p.L101L	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	78	Ig-like V-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TGGCCTCTCAGGATTATTTCC	0.423000													16	30					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106204124	106204124	+	RNA	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr14:106204124C>T	ENST00000390548.2	-	0	1174																											GATCATGTTCCTGTAGTCGGG	0.647000													28	30					0	0	1	0	0
RP11-876N24.2	0	broad.mit.edu	37	16	10960208	10960208	+	RNA	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:10960208G>A	ENST00000572017.1	-	0	438																											CATCAGCCCAGCCTGGTGCAG	0.607000													14	11					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215848503	215848503	+	Missense_Mutation	SNP	C	C	T	rs78964730	byFrequency	TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:215848503C>T	ENST00000272895.7	-	29	4469	c.4250G>A	c.(4249-4251)cGg>cAg	p.R1417Q	ABCA12_ENST00000389661.4_Missense_Mutation_p.R1099Q	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1417	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CATGTTCTTCCGTACCGTGTG	0.453000													24	53					0	0	1	0	0
ITK	3702	broad.mit.edu	37	5	156667109	156667109	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:156667109G>A	ENST00000422843.3	+	10	1041	c.889G>A	c.(889-891)Gaa>Aaa	p.E297K		NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	297	SH2.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCACATCAAGGAAACAAATGA	0.348000			T	SYK	peripheral T-cell lymphoma								15	10					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94883438	94883438	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:94883438G>A	ENST00000357742.4	+	5	791	c.791G>A	c.(790-792)cGa>cAa	p.R264Q	MCTP2_ENST00000331706.4_5'UTR|MCTP2_ENST00000451018.3_Missense_Mutation_p.R264Q|MCTP2_ENST00000543482.1_Missense_Mutation_p.R264Q	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	264	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GTATATGATCGAGATTTAACC	0.318000													19	40					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85436411	85436411	+	Silent	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:85436411A>G	ENST00000359152.5	-	1	2660	c.2661T>C	c.(2659-2661)gaT>gaC	p.D887D	SYTL2_ENST00000354566.3_Silent_p.D363D|SYTL2_ENST00000525423.1_Silent_p.D363D|SYTL2_ENST00000316356.4_Intron|SYTL2_ENST00000527523.1_Intron|SYTL2_ENST00000528231.1_Intron|SYTL2_ENST00000524452.1_Intron|SYTL2_ENST00000389960.4_Intron	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	0					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		GAAAAAGCATATCTTGGGGAG	0.483000													22	28					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369832	56369832	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:56369832G>A	ENST00000301295.6	+	3	1495	c.1073G>A	c.(1072-1074)gGa>gAa	p.G358E	NLRP4_ENST00000346986.5_Missense_Mutation_p.G358E|NLRP4_ENST00000587891.1_Missense_Mutation_p.G283E	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	358	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ATGCAGAAAGGAAAAGACCTG	0.512000													4	16					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104033936	104033936	+	Silent	SNP	C	C	T	rs144975292		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:104033936C>T	ENST00000388887.2	+	9	1146	c.942C>T	c.(940-942)ttC>ttT	p.F314F		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	314					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity	p.F314F(1)		NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ACCAGAATTTCGTACCTGGAG	0.448000													31	40					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103718289	103718289	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr13:103718289C>T	ENST00000245312.3	-	1	907	c.311G>A	c.(310-312)gGa>gAa	p.G104E		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	104					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AGGGCAGCATCCTATAATGAG	0.517000													33	38					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38595774	38595774	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:38595774G>A	ENST00000413689.1	-	27	5002	c.4809C>T	c.(4807-4809)atC>atT	p.I1603I	SCN5A_ENST00000443581.1_Silent_p.I1602I|SCN5A_ENST00000464652.1_5'UTR|SCN5A_ENST00000423572.2_Silent_p.I1602I|SCN5A_ENST00000455624.2_Intron|SCN5A_ENST00000414099.2_Silent_p.I1585I|SCN5A_ENST00000451551.2_Silent_p.I1549I|SCN5A_ENST00000333535.4_Silent_p.I1603I|SCN5A_ENST00000450102.2_Silent_p.I1549I|SCN5A_ENST00000449557.2_Silent_p.I1549I|SCN5A_ENST00000425664.1_Silent_p.I1585I	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1603					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACCCACCCACGATGGAGAGGA	0.562000													20	5					0	0	1	0	0
SEC24B	10427	broad.mit.edu	37	4	110415963	110415963	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr4:110415963G>A	ENST00000265175.5	+	6	1494	c.1439G>A	c.(1438-1440)gGa>gAa	p.G480E	SEC24B_ENST00000504968.2_Missense_Mutation_p.G511E|SEC24B_ENST00000399100.2_Missense_Mutation_p.G445E	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	480					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CTTATTTCTGGAGTACAGCCC	0.418000													30	14					0	0	1	0	0
CPNE9	151835	broad.mit.edu	37	3	9768363	9768363	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:9768363C>T	ENST00000383832.3	+	19	1549	c.1359C>T	c.(1357-1359)ccC>ccT	p.P453P	CPNE9_ENST00000383831.3_Silent_p.P453P	NM_153635.2	NP_705899.2	Q8IYJ1	CPNE9_HUMAN	copine family member IX	453	VWFA.									breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16	Medulloblastoma(99;0.227)					CCTCATTGCCCATGTCTATCA	0.527000													22	50					0	0	1	0	0
OR14A16	284532	broad.mit.edu	37	1	247978950	247978950	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:247978950G>A	ENST00000357627.1	-	1	81	c.82C>T	c.(82-84)Ctc>Ttc	p.L28F		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						AACAAGAAGAGAATCGAATGC	0.388000													9	15					0	0	1	0	0
INTS4P2	644619	broad.mit.edu	37	7	65157789	65157789	+	RNA	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:65157789G>A	ENST00000430126.2	+	0	1116																											GCCTACCTCCGAGACAGTCTT	0.423000													10	38					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9310436	9310436	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:9310436C>T	ENST00000261336.2	-	27	3324	c.3294_splice	c.e27-1	p.G1099_splice	PZP_ENST00000381997.2_Splice_Site_p.G885_splice	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						TTCTACACCTCCCTGTGAATA	0.438000													5	6					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161052932	161052932	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:161052932C>T	ENST00000283249.2	-	3	379		c.e3-1		ITGB6_ENST00000485635.1_Splice_Site|ITGB6_ENST00000409967.2_Splice_Site|ITGB6_ENST00000409872.1_Splice_Site|ITGB6_ENST00000428609.2_Splice_Site			P18564	ITB6_HUMAN	integrin, beta 6						cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						GAGTAAAATTCTAAAAAAGAA	0.338000													29	44					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42635408	42635408	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:42635408C>T	ENST00000358131.5	+	3	622	c.414C>T	c.(412-414)caC>caT	p.H138H	TOX2_ENST00000372999.1_Silent_p.H87H|TOX2_ENST00000423191.1_Silent_p.H87H|TOX2_ENST00000341197.3_Silent_p.H129H	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGGACAGCCACCTGCTGTCGG	0.617000													7	15					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45987709	45987709	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr21:45987709G>A	ENST00000323084.4	-	2	328	c.263C>T	c.(262-264)tCc>tTc	p.S88F	TSPEAR_ENST00000397916.1_Missense_Mutation_p.S20F	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	88	TSP N-terminal.				cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						TACGACGATGGAAAATTCTTC	0.522000													13	21					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167055212	167055212	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:167055212T>A	ENST00000303354.6	-	27	6280	c.5940A>T	c.(5938-5940)aaA>aaT	p.K1980N	AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409435.1_Missense_Mutation_p.K1979N|SCN9A_ENST00000409672.1_Missense_Mutation_p.K1968N|SCN9A_ENST00000375387.4_Missense_Mutation_p.K1980N			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	1979						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGTCTTTCCCTTTGTCTTCCT	0.358000													7	9					0	0	1	0	0
TRIM54	57159	broad.mit.edu	37	2	27521556	27521556	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:27521556G>A	ENST00000296098.4	+	2	560	c.290G>A	c.(289-291)cGa>cAa	p.R97Q	TRIM54_ENST00000380075.2_Missense_Mutation_p.R97Q	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	97					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding	p.R81Q(1)		cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCTGCAGCGAAACCTGCTA	0.572000													14	14					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28483301	28483301	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:28483301G>A	ENST00000261609.7	-	25	3919	c.3811C>T	c.(3811-3813)Cgg>Tgg	p.R1271W		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1271	Cytochrome b5 heme-binding.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATGGATTCCCGGGTGTCTTCA	0.493000													23	41					0	0	1	0	0
MAP2K1	5604	broad.mit.edu	37	15	66729162	66729162	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr15:66729162C>T	ENST00000307102.5	+	3	901	c.370C>T	c.(370-372)Ccg>Tcg	p.P124S		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	124	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.P124S(8)		endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						GTGCAACTCTCCGTACATCGT	0.507000													25	26					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823280	38823280	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr22:38823280G>A	ENST00000303592.3	-	2	1116	c.858C>T	c.(856-858)atC>atT	p.I286I	RP3-434P1.6_ENST00000433230.1_RNA	NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	286					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					GGATGACCACGATCTCAAAGT	0.622000													13	19					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153655045	153655045	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:153655045C>T	ENST00000368680.3	+	5	1715	c.1243C>T	c.(1243-1245)Ccc>Tcc	p.P415S		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	415					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GGATATGGATCCCGAGAATGG	0.522000													7	13					0	0	1	0	0
IRX4	50805	broad.mit.edu	37	5	1879629	1879629	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:1879629G>A	ENST00000505790.1	-	5	1181	c.725C>T	c.(724-726)tCc>tTc	p.S242F	IRX4_ENST00000231357.2_Missense_Mutation_p.S242F|IRX4_ENST00000513692.1_Missense_Mutation_p.S242F|IRX4_ENST00000505938.1_5'UTR	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	242					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		TGCGTTCTTGGAGCTCTTGAG	0.682000													23	8					0	0	1	0	0
OR1E2	8388	broad.mit.edu	37	17	3336383	3336383	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:3336383G>A	ENST00000248384.1	-	1	752	c.753C>T	c.(751-753)ggC>ggT	p.G251G		NM_003554.1	NP_003545.1	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E, member 2	251					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)	9						AGAGGTGGGAGCCACAAGTAG	0.478000													9	29					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6828862	6828862	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:6828862G>A	ENST00000304076.2	+	13	1310	c.1216G>A	c.(1216-1218)Gac>Aac	p.D406N	VAV1_ENST00000596764.1_Missense_Mutation_p.D374N|VAV1_ENST00000602142.1_Missense_Mutation_p.D406N|VAV1_ENST00000539284.1_Missense_Mutation_p.D309N|VAV1_ENST00000599806.1_Missense_Mutation_p.D351N	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	406	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						GCCCAAGATCGACGGGGAACT	0.597000													13	21					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119341252	119341252	+	Missense_Mutation	SNP	G	G	A	rs141308759		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:119341252G>A	ENST00000338891.7	-	4	1666	c.1223C>T	c.(1222-1224)tCg>tTg	p.S408L	RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000368475.4_Missense_Mutation_p.S288L|FAM184A_ENST00000521531.1_Missense_Mutation_p.S408L|FAM184A_ENST00000522284.1_Missense_Mutation_p.S288L|FAM184A_ENST00000352896.5_Missense_Mutation_p.S288L	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	408								p.S408L(1)		breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						ATTGACTCTCGATTTTTCTGA	0.373000													22	20					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184049296	184049296	+	Missense_Mutation	SNP	C	C	T	rs147696097		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:184049296C>T	ENST00000342981.4	+	29	4714	c.4300C>T	c.(4300-4302)Cct>Tct	p.P1434S	EIF4G1_ENST00000382330.3_Missense_Mutation_p.P1440S|EIF4G1_ENST00000424196.1_Missense_Mutation_p.P1440S|EIF4G1_ENST00000441154.1_Missense_Mutation_p.P1270S|EIF4G1_ENST00000350481.5_Missense_Mutation_p.P1269S|EIF4G1_ENST00000319274.6_Missense_Mutation_p.P1433S|EIF4G1_ENST00000435046.2_Missense_Mutation_p.P1237S|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000434061.2_Missense_Mutation_p.P1238S|EIF4G1_ENST00000392537.2_Missense_Mutation_p.P1346S|EIF4G1_ENST00000346169.2_Missense_Mutation_p.P1433S|EIF4G1_ENST00000427845.1_Missense_Mutation_p.P1347S|EIF4G1_ENST00000352767.3_Missense_Mutation_p.P1440S|EIF4G1_ENST00000411531.1_Missense_Mutation_p.P1394S|EIF4G1_ENST00000414031.1_Missense_Mutation_p.P1393S	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1433	W2.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GTCGGAAGCCCCTGGCCAGAG	0.572000													61	97					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140434522	140434522	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:140434522G>A	ENST00000288602.6	-	18	2236	c.2176C>T	c.(2176-2178)Cgc>Tgc	p.R726C		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	726					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GATGCACTGCGGTGAATTTTT	0.403000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				56	81					0	0	1	0	0
FAM192A	80011	broad.mit.edu	37	16	57206772	57206772	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:57206772C>T	ENST00000309137.8	-	3	400	c.142G>A	c.(142-144)Gtt>Att	p.V48I	FAM192A_ENST00000566077.1_5'UTR|FAM192A_ENST00000389447.5_Missense_Mutation_p.V48I|FAM192A_ENST00000569266.1_Missense_Mutation_p.V48I|FAM192A_ENST00000564108.1_Missense_Mutation_p.V48I|FAM192A_ENST00000567439.1_Missense_Mutation_p.V48I	NM_024946.2	NP_079222.1	Q9GZU8	F192A_HUMAN	family with sequence similarity 192, member A	48						nucleus				endometrium(2)|large_intestine(3)|lung(4)|prostate(2)	11						GGGTCATAAACCTCCTCTGGA	0.428000													15	28					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156500019	156500019	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:156500019G>A	ENST00000361170.2	-	34	4292	c.4282C>T	c.(4282-4284)Cac>Tac	p.H1428Y		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1428					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGAGGGAGTGAGCTGTCAGT	0.652000													14	15					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99640534	99640534	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:99640534G>A	ENST00000547776.2	-	13	1864	c.1865C>T	c.(1864-1866)cCa>cTa	p.P622L	ANKS1B_ENST00000329257.7_Missense_Mutation_p.P622L|ANKS1B_ENST00000550833.1_5'UTR|ANKS1B_ENST00000547010.1_Missense_Mutation_p.P202L	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	622						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GAGATGAAATGGATTTTCAGG	0.448000													42	69					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7586024	7586024	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:7586024C>T	ENST00000313599.3	-	3	448	c.391G>A	c.(391-393)Gaa>Aaa	p.E131K	CD163L1_ENST00000416109.2_Missense_Mutation_p.E131K|CD163L1_ENST00000396630.1_Missense_Mutation_p.E131K			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	131	SRCR 1.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CTTCCCCATTCCCGGTGTTGA	0.438000													21	48					0	0	1	0	0
MINA	84864	broad.mit.edu	37	3	97686114	97686114	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:97686114C>T	ENST00000333396.6	-	2	906	c.324G>A	c.(322-324)ggG>ggA	p.G108G	MINA_ENST00000394198.2_Silent_p.G108G|MINA_ENST00000330299.2_Silent_p.G108G|MINA_ENST00000360258.4_Silent_p.G108G	NM_001042533.2|NM_032778.5	NP_001035998.1|NP_116167.3	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen	108					ribosome biogenesis	cytoplasm|nucleolus				breast(2)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)	13						CCTTCTTCTTCCCATTGACAC	0.438000													78	139					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20010427	20010427	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr13:20010427C>T	ENST00000400230.2	-	15	1099	c.1055G>A	c.(1054-1056)gGa>gAa	p.G352E	TPTE2_ENST00000382977.4_Missense_Mutation_p.G352E|TPTE2_ENST00000400103.2_Missense_Mutation_p.G241E|TPTE2_ENST00000382975.4_Missense_Mutation_p.G312E|TPTE2_ENST00000255310.6_Missense_Mutation_p.G275E|TPTE2_ENST00000457266.2_Missense_Mutation_p.G241E|TPTE2_ENST00000390680.2_Missense_Mutation_p.G275E|TPTE2_ENST00000382978.1_Missense_Mutation_p.G312E			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	352	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TCGCCTTTCTCCAAAATAATA	0.368000													9	17					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85446859	85446859	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:85446859G>A	ENST00000369663.5	-	8	1705	c.1368C>T	c.(1366-1368)tcC>tcT	p.S456S	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	456					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		CGCCCACATAGGAGGGAGTCC	0.582000													31	45					0	0	1	0	0
PKD2L2	27039	broad.mit.edu	37	5	137243556	137243556	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:137243556T>A	ENST00000508638.1	+	7	1156	c.1101T>A	c.(1099-1101)taT>taA	p.Y367*	PKD2L2_ENST00000502810.1_Nonsense_Mutation_p.Y345*|PKD2L2_ENST00000350250.4_Nonsense_Mutation_p.Y333*|PKD2L2_ENST00000290431.5_Nonsense_Mutation_p.Y367*|PKD2L2_ENST00000508883.1_Nonsense_Mutation_p.Y367*	NM_001258449.1	NP_001245378.1	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	367						integral to membrane	calcium ion binding|ion channel activity			breast(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	28			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GGCACATTTATTACAATAATA	0.259000													10	2					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46771695	46771695	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr16:46771695G>A	ENST00000394809.4	-	3	1044	c.929C>T	c.(928-930)cCt>cTt	p.P310L	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	310					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TGGGCACTGAGGGCCAGGCCC	0.652000													32	43					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24817049	24817049	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr10:24817049G>A	ENST00000376451.2	+	9	2391		c.e9+1		KIAA1217_ENST00000376454.3_Splice_Site|KIAA1217_ENST00000430453.2_Splice_Site|KIAA1217_ENST00000458595.1_Splice_Site|KIAA1217_ENST00000376462.1_Splice_Site|KIAA1217_ENST00000376452.3_Splice_Site|KIAA1217_ENST00000307544.6_Splice_Site|KIAA1217_ENST00000396446.1_Splice_Site|KIAA1217_ENST00000396445.1_Splice_Site			Q5T5P2	SKT_HUMAN	KIAA1217						embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GAACTTTCAGGTAAGTTCCGG	0.512000													3	31					0	0	1	0	0
AQP10	89872	broad.mit.edu	37	1	154296186	154296186	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:154296186C>T	ENST00000484864.1	+	5	647	c.611C>T	c.(610-612)tCc>tTc	p.S204F	AQP10_ENST00000324978.3_Missense_Mutation_p.S204F|AQP10_ENST00000355197.4_3'UTR			Q96PS8	AQP10_HUMAN	aquaporin 10	204					response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|stomach(2)|upper_aerodigestive_tract(1)	23	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTCGGGTTATCCATGGGTGCC	0.632000													35	61					0	0	1	0	0
CACTIN	58509	broad.mit.edu	37	19	3612182	3612182	+	Silent	SNP	G	G	A	rs147636108	by1000genomes	TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:3612182G>A	ENST00000429344.2	-	10	2068	c.2016C>T	c.(2014-2016)atC>atT	p.I672I	CACTIN-AS1_ENST00000592274.1_RNA|CACTIN_ENST00000248420.5_Silent_p.I672I|CACTIN_ENST00000221899.3_Silent_p.I604I	NM_001080543.1	NP_001074012.1			cactin, spliceosome C complex subunit																		ATCCCTGCACGATCTTGGGCG	0.582000													76	102					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213872299	213872299	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:213872299C>T	ENST00000457361.1	-	8	1534	c.1366G>A	c.(1366-1368)Gac>Aac	p.D456N	IKZF2_ENST00000421754.2_Missense_Mutation_p.D382N|IKZF2_ENST00000374327.4_Missense_Mutation_p.D311N|IKZF2_ENST00000451136.2_Missense_Mutation_p.D384N|IKZF2_ENST00000374319.4_Missense_Mutation_p.D430N|IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000434687.1_Missense_Mutation_p.D456N|IKZF2_ENST00000342002.2_Missense_Mutation_p.D462N	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.D456N(1)		NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		TTGTAGATGTCCTTCAGAGAG	0.473000													36	85					0	0	1	0	0
TAF7	6879	broad.mit.edu	37	5	140698781	140698781	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:140698781C>T	ENST00000313368.5	-	1	1549	c.831G>A	c.(829-831)ctG>ctA	p.L277L		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	277					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding	p.L277L(1)		central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCCATAACCAGCTGATTGG	0.443000													37	15					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890561	229890561	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:229890561G>A	ENST00000392054.3	-	4	873	c.534C>T	c.(532-534)ttC>ttT	p.F178F	PID1_ENST00000409462.1_Silent_p.F98F|PID1_ENST00000354069.6_Silent_p.F180F|PID1_ENST00000392055.3_Silent_p.F147F|PID1_ENST00000482518.2_Intron	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	180	PID.					cytoplasm		p.F178F(2)		breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		AGACCCAGGCGAAGATGTTGG	0.602000													34	39					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108189571	108189571	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:108189571C>T	ENST00000273353.3	-	14	1473	c.1417G>A	c.(1417-1419)Gac>Aac	p.D473N		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	473	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CCAGTGATGTCAAGAATGCCA	0.413000													15	18					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53189313	53189313	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:53189313C>T	ENST00000417996.2	-	1	588	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	KRT3_ENST00000309505.3_Missense_Mutation_p.E172K	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	172	Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity	p.E172K(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						ATAGTCACTTCCTGAATTCCC	0.597000													19	26					0	0	1	0	0
NUDT1	4521	broad.mit.edu	37	7	2289596	2289596	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:2289596T>C	ENST00000397049.1	+	4	428	c.326T>C	c.(325-327)tTc>tCc	p.F109S	NUDT1_ENST00000356714.1_Missense_Mutation_p.F86S|NUDT1_ENST00000343985.4_Missense_Mutation_p.F109S|NUDT1_ENST00000339737.2_Missense_Mutation_p.F86S|NUDT1_ENST00000397048.1_Missense_Mutation_p.F109S|NUDT1_ENST00000487426.1_3'UTR|NUDT1_ENST00000397046.1_Missense_Mutation_p.F86S	NM_198948.1|NM_198949.1	NP_945186.1|NP_945187.1	P36639	8ODP_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 1	127	Nudix hydrolase.				DNA protection|DNA repair|response to oxidative stress	cytoplasm	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|GTPase activity|metal ion binding|protein binding			large_intestine(3)|lung(8)|urinary_tract(1)	12		Ovarian(82;0.0253)|Melanoma(862;0.155)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.8e-14)|BRCA - Breast invasive adenocarcinoma(126;0.15)		GTGCATGTCTTCTGCACAGAC	0.642000								Modulation of nucleotide pools					54	81					0	0	1	0	0
CFHR3	10878	broad.mit.edu	37	1	196748942	196748942	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:196748942C>T	ENST00000471440.2	+	3	343	c.269C>T	c.(268-270)cCt>cTt	p.P90L	CFHR3_ENST00000367425.4_Missense_Mutation_p.P90L|CFHR3_ENST00000391985.3_Missense_Mutation_p.P90L					complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						TGTTATTTTCCTTATTTGGAA	0.303000													4	10					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53669384	53669384	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:53669384A>G	ENST00000600412.1	-	2	279	c.164T>C	c.(163-165)cTc>cCc	p.L55P	ZNF665_ENST00000396424.3_Missense_Mutation_p.L120P			Q9H7R5	ZN665_HUMAN	zinc finger protein 665	55					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		TCTACCAGGGAGATTTTCTTT	0.403000													46	61					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12661487	12661487	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:12661487C>T	ENST00000425538.1	+	12	2488	c.2288C>T	c.(2287-2289)tCa>tTa	p.S763L	MYOCD_ENST00000395988.1_Missense_Mutation_p.S667L|MYOCD_ENST00000343344.4_Missense_Mutation_p.S715L	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	715					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCAGCAATTTCAGAGGTAACA	0.408000													14	20					0	0	1	0	0
RBMS2	5939	broad.mit.edu	37	12	56965488	56965488	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:56965488G>A	ENST00000262031.5	+	5	486	c.391G>A	c.(391-393)Gaa>Aaa	p.E131K	RBMS2_ENST00000550726.1_Missense_Mutation_p.E6K|RBMS2_ENST00000549945.1_3'UTR|RBMS2_ENST00000552247.2_Missense_Mutation_p.E131K|RBMS2_ENST00000542360.1_Intron	NM_002898.3	NP_002889.1	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting protein 2	131					RNA processing	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(3)|skin(2)|urinary_tract(1)	18						ACAGCAACAGGAACAGGACCC	0.483000													24	20					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62324500	62324500	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:62324500C>T	ENST00000318100.4	+	30	3683	c.2856C>T	c.(2854-2856)ttC>ttT	p.F952F	RTEL1-TNFRSF6B_ENST00000482936.1_Silent_p.F952F|RTEL1_ENST00000370003.1_Silent_p.F197F|RTEL1_ENST00000370018.3_Silent_p.F952F|RTEL1_ENST00000508582.2_Silent_p.F976F|RTEL1_ENST00000360203.5_Silent_p.F952F			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	952					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CTACAGGCTTCTACCAGTTTG	0.602000													44	58					0	0	1	0	0
TNFAIP2	7127	broad.mit.edu	37	14	103593823	103593823	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr14:103593823C>G	ENST00000560869.1	+	3	1356	c.717C>G	c.(715-717)ttC>ttG	p.F239L	TNFAIP2_ENST00000333007.1_Missense_Mutation_p.F239L			Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	239					angiogenesis|cell differentiation	extracellular space				NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	11		Melanoma(154;0.155)	Epithelial(46;0.191)			AGCCGCTGTTCCCCGCCGAGT	0.721000													10	8					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52836730	52836730	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:52836730G>A	ENST00000449956.2	+	13	1623	c.1617G>A	c.(1615-1617)atG>atA	p.M539I	ITIH3_ENST00000416872.2_Intron	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	539					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TGAAGGAGATGGAGAAGGCCC	0.592000													22	18					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13769570	13769570	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:13769570A>G	ENST00000279593.3	-	5	1356	c.1147T>C	c.(1147-1149)Tcc>Ccc	p.S383P		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	383					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATCTGCAGGGACTTGTCTTTC	0.498000													15	31					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93650798	93650798	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:93650798G>A	ENST00000375754.4	+	13	1872	c.1722_splice	c.e13-1	p.G575_splice	SYK_ENST00000375747.1_Splice_Site_p.G552_splice|SYK_ENST00000375751.4_Splice_Site_p.G552_splice|SYK_ENST00000375746.1_Splice_Site_p.G575_splice	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	575	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						ATGTTGTAGGGGATGAAAGGA	0.428000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								4	9					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46826212	46826212	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:46826212G>A	ENST00000283296.7	-	17	3716	c.3428C>T	c.(3427-3429)tCg>tTg	p.S1143L	GPR116_ENST00000545669.1_Missense_Mutation_p.S572L|GPR116_ENST00000265417.7_Missense_Mutation_p.S1143L|GPR116_ENST00000362015.4_Missense_Mutation_p.S1143L|GPR116_ENST00000456426.2_Missense_Mutation_p.S1001L	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	1143					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			CGTGATGACCGAGATGGCAAG	0.552000													8	17					0	0	1	0	0
PRKAR1A	5573	broad.mit.edu	37	17	66522027	66522027	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:66522027C>T	ENST00000589228.1	+	7	810	c.682C>T	c.(682-684)Cga>Tga	p.R228*	PRKAR1A_ENST00000536854.2_Nonsense_Mutation_p.R228*|PRKAR1A_ENST00000586397.1_Nonsense_Mutation_p.R228*|PRKAR1A_ENST00000392711.1_Nonsense_Mutation_p.R228*|PRKAR1A_ENST00000358598.2_Nonsense_Mutation_p.R228*|PRKAR1A_ENST00000588188.2_Nonsense_Mutation_p.R228*	NM_001276289.1|NM_001278433.1	NP_001263218.1|NP_001265362.1	P10644	KAP0_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, alpha	228					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity|protein binding			adrenal_gland(4)|breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|soft_tissue(2)|stomach(2)|testis(1)|thyroid(2)|upper_aerodigestive_tract(1)	31	Breast(10;1.64e-13)					GGGCATCGACCGAGACAGCTA	0.418000			"""T, Mis, N, F, S"""	RET	papillary thyroid	"""myxoma, endocrine, papillary thyroid"""			Primary Pigmented Nodular Adrenocortical Disease, Familial;Carney Complex;Cardiac Myxomas, Familial Clustering of				14	5					0	0	1	0	0
USP19	10869	broad.mit.edu	37	3	49147649	49147649	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:49147649G>A	ENST00000453664.1	-	26	4288	c.3970C>T	c.(3970-3972)Cta>Tta	p.L1324L	USP19_ENST00000417901.1_Silent_p.L1336L|USP19_ENST00000398888.2_Silent_p.L1233L|USP19_ENST00000398892.3_Silent_p.L1273L|USP19_ENST00000398896.1_Silent_p.L1041L|USP19_ENST00000398898.2_Silent_p.L1273L|USP19_ENST00000434032.2_Silent_p.L1334L	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	1233					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCAGGGCCTAGGTCTGGGTGG	0.622000													37	10					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29102112	29102112	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr18:29102112C>T	ENST00000261590.8	+	6	799	c.590C>T	c.(589-591)tCc>tTc	p.S197F	DSG2_ENST00000585206.1_Missense_Mutation_p.S197F	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	197	Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TCGAAAATTTCCTATAGAATC	0.378000													16	12					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92731648	92731648	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:92731648G>A	ENST00000379958.2	-	3	4032	c.3763C>T	c.(3763-3765)Cct>Tct	p.P1255S		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1255						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTTAAATAAGGAATATAGTTT	0.289000													21	36					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238280832	238280832	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:238280832G>T	ENST00000295550.4	-	9	4280	c.3828C>A	c.(3826-3828)ttC>ttA	p.F1276L	COL6A3_ENST00000392004.3_Missense_Mutation_p.F1070L|COL6A3_ENST00000472056.1_Missense_Mutation_p.F669L|COL6A3_ENST00000409809.1_Missense_Mutation_p.F1070L|COL6A3_ENST00000347401.3_Missense_Mutation_p.F1075L|COL6A3_ENST00000392003.2_Missense_Mutation_p.F869L|COL6A3_ENST00000353578.4_Missense_Mutation_p.F1070L|COL6A3_ENST00000346358.4_Missense_Mutation_p.F1076L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1276	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGTCATCGCTGAACTGGATGA	0.617000													11	18					3.86212e-05	3.91241e-05	1	1	0
TMEM132B	114795	broad.mit.edu	37	12	125834785	125834785	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:125834785G>A	ENST00000299308.3	+	2	848	c.840G>A	c.(838-840)gaG>gaA	p.E280E		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	280						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GCTTGGACGAGAATGTGGTCA	0.562000													53	90					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27706215	27706215	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:27706215G>A	ENST00000260570.3	-	7	614	c.511C>T	c.(511-513)Cat>Tat	p.H171Y	IFT172_ENST00000416524.2_Missense_Mutation_p.H150Y|IFT172_ENST00000359466.6_Missense_Mutation_p.H171Y	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	171					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					CCATCTGCATGACCAGAGAGA	0.423000													14	21					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41450722	41450722	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr21:41450722G>A	ENST00000400454.1	-	26	5080	c.4603C>T	c.(4603-4605)Ctg>Ttg	p.L1535L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1535	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGGTCATACAGGATGTAGGAC	0.582000													9	8					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	70853245	70853245	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:70853245G>A	ENST00000333538.5	+	3	1081	c.447G>A	c.(445-447)aaG>aaA	p.K149K	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	149						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AGTACTCCAAGGACCTGCCCC	0.537000													16	20					0	0	1	0	0
ABHD4	63874	broad.mit.edu	37	14	23072966	23072966	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr14:23072966C>T	ENST00000428304.2	+	4	692	c.622C>T	c.(622-624)Cga>Tga	p.R208*	ABHD4_ENST00000544562.1_3'UTR	NM_022060.2	NP_071343.2	Q8TB40	ABHD4_HUMAN	abhydrolase domain containing 4	208					lipid catabolic process		hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(3)|prostate(1)	14	all_cancers(95;5.49e-05)			GBM - Glioblastoma multiforme(265;0.0153)		GGCTGTTCTTCGAGTAGCTGG	0.532000													23	24					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32130825	32130825	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:32130825C>T	ENST00000373672.3	-	56	4019	c.3503G>A	c.(3502-3504)gGa>gAa	p.G1168E	COL16A1_ENST00000271069.6_Missense_Mutation_p.G1168E	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1168	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GCCTGGGAATCCAGGGGGACC	0.567000													30	12					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74043654	74043654	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:74043654C>T	ENST00000409561.1	+	3	2425	c.2304C>T	c.(2302-2304)tcC>tcT	p.S768S		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	768										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TCAATCCATCCCGACCAGCTC	0.557000													13	29					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33690141	33690141	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:33690141C>T	ENST00000394566.1	-	4	958	c.686G>A	c.(685-687)aGg>aAg	p.R229K	SLFN11_ENST00000308377.4_Missense_Mutation_p.R229K	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	229						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGGAATTGTCCTTTTTACATA	0.388000													31	43					0	0	1	0	0
CYP3A4	1576	broad.mit.edu	37	7	99375663	99375663	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:99375663C>T	ENST00000336411.2	-	3	389	c.206G>A	c.(205-207)gGa>gAa	p.G69E	CYP3A4_ENST00000354593.2_Intron	NM_001202855.2|NM_017460.5	NP_001189784.1|NP_059488.2	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 4	69					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			breast(3)|central_nervous_system(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	CCACACTTTTCCATACTTTTT	0.388000													19	36					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4907322	4907322	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:4907322C>T	ENST00000320785.5	+	11	1251	c.894C>T	c.(892-894)atC>atT	p.I298I		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	298					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						CGGATTTTATCCCCTACAGGG	0.522000													33	63					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215809759	215809759	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:215809759G>T	ENST00000272895.7	-	49	7528	c.7309C>A	c.(7309-7311)Cag>Aag	p.Q2437K	AC072062.1_ENST00000607412.1_RNA|ABCA12_ENST00000389661.4_Missense_Mutation_p.Q2119K	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2437	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CATTTGTTCTGTACTTCTTCT	0.418000													5	16					1.23904e-05	1.26174e-05	1	1	0
BRAF	673	broad.mit.edu	37	7	140434523	140434523	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:140434523G>A	ENST00000288602.6	-	18	2235	c.2175C>T	c.(2173-2175)caC>caT	p.H725H		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	725					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	ATGCACTGCGGTGAATTTTTG	0.398000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				54	82					0	0	1	0	0
DPYSL5	56896	broad.mit.edu	37	2	27169838	27169838	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:27169838G>A	ENST00000288699.6	+	13	1828	c.1670G>A	c.(1669-1671)gGa>gAa	p.G557E	DPYSL5_ENST00000401478.1_Missense_Mutation_p.G557E	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	557					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTCCTCCCGGAGGCAGGTCG	0.627000													11	10					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187584	123187584	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:123187584G>A	ENST00000328880.5	-	1	306	c.247C>T	c.(247-249)Ctg>Ttg	p.L83L	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	83					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	TTGTCCATCAGGAAGGGCAGG	0.522000													16	33					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155566166	155566166	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:155566166G>A	ENST00000295101.2	+	2	1231	c.754G>A	c.(754-756)Gat>Aat	p.D252N	KCNJ3_ENST00000493505.1_3'UTR|KCNJ3_ENST00000544049.1_Intron	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	252					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	ACTTGAACTGGATGTAGGTTT	0.463000													23	40					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216873	21216873	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr9:21216873C>T	ENST00000380216.1	-	1	437	c.432G>A	c.(430-432)agG>agA	p.R144R		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	144					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GAAAGTATTTCCTCACAGCCA	0.458000													68	43					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121651007	121651007	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr7:121651007C>T	ENST00000393386.2	+	12	2318	c.1907C>T	c.(1906-1908)tCa>tTa	p.S636L	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.S636L	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	636					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GATTCAACTTCATCAGGTTCA	0.418000													16	18					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108035942	108035942	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr12:108035942C>T	ENST00000280758.5	+	14	3444	c.2916C>T	c.(2914-2916)atC>atT	p.I972I	BTBD11_ENST00000490090.2_Silent_p.I972I|BTBD11_ENST00000420571.2_Silent_p.I853I|BTBD11_ENST00000357167.4_Silent_p.I509I|BTBD11_ENST00000494235.2_Silent_p.I51I	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	972	BTB.					integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AATACTCCATCTTTCAGGTGA	0.517000													25	29					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52336291	52336291	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:52336291C>T	ENST00000356297.4	-	14	1739	c.1638_splice	c.e14-1	p.E547_splice	PXDNL_ENST00000543296.1_Splice_Site_p.E547_splice	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	547	Ig-like C2-type 4.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TGCACACCTTCCTAGGGAGCA	0.398000													8	10					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20493232	20493232	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr20:20493232G>A	ENST00000202677.6	-	32	4923	c.4781C>T	c.(4780-4782)cCa>cTa	p.P1594L		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	1594					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						GGGCTCCACTGGGGAGGGCTG	0.473000													6	17					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167420120	167420120	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:167420120G>A	ENST00000519204.1	+	4	874	c.756G>A	c.(754-756)tgG>tgA	p.W252*	TENM2_ENST00000520394.1_Nonsense_Mutation_p.W182*|TENM2_ENST00000403607.2_Nonsense_Mutation_p.W206*|TENM2_ENST00000545108.1_Nonsense_Mutation_p.W373*|TENM2_ENST00000518659.1_Nonsense_Mutation_p.W373*					teneurin transmembrane protein 2																		ACTGCAGCTGGAAATGTGCTG	0.567000													22	9					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86934746	86934746	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:86934746G>A	ENST00000234701.3	+	2	443	c.92G>A	c.(91-93)gGc>gAc	p.G31D	CLCA1_ENST00000394711.1_Missense_Mutation_p.G31D			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	31					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		AACAACAATGGCTATGAAGGC	0.398000													22	14					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117622181	117622181	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:117622181C>T	ENST00000368508.3	-	42	6887	c.6689G>A	c.(6688-6690)aGa>aAa	p.R2230K	ROS1_ENST00000368507.3_Missense_Mutation_p.R2224K	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2230					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGCTTCATCTCTGGACTTATA	0.363000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								18	13					0	0	1	0	0
SARS2	54938	broad.mit.edu	37	19	39406325	39406325	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:39406325G>A	ENST00000221431.6	-	16	1637	c.1478C>T	c.(1477-1479)cCt>cTt	p.P493L	SARS2_ENST00000430193.3_Missense_Mutation_p.P493L|SARS2_ENST00000600042.1_Missense_Mutation_p.P495L|SARS2_ENST00000448145.2_Missense_Mutation_p.P493L|CTC-360G5.8_ENST00000599996.1_Silent_p.P562P|SARS2_ENST00000598831.1_Missense_Mutation_p.P141L|SARS2_ENST00000594171.1_Missense_Mutation_p.P303L	NM_017827.3	NP_060297.1	Q9NP81	SYSM_HUMAN	seryl-tRNA synthetase 2, mitochondrial	493					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CACGTGGGTAGGGGCTGTGAT	0.652000													23	33					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44061091	44061091	+	Silent	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr17:44061091C>T	ENST00000344290.5	+	6	1243	c.921C>T	c.(919-921)atC>atT	p.I307I	MAPT_ENST00000574436.1_Intron|MAPT_ENST00000571987.1_Silent_p.I307I|MAPT_ENST00000570299.1_Intron|MAPT_ENST00000535772.1_Intron|MAPT_ENST00000446361.3_Intron|MAPT_ENST00000340799.5_Intron|MAPT_ENST00000431008.3_Intron|MAPT_ENST00000420682.2_Intron|MAPT_ENST00000415613.2_Silent_p.I307I|MAPT_ENST00000351559.5_Intron|MAPT_ENST00000347967.5_Intron|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000262410.5_Silent_p.I307I|MAPT_ENST00000576518.1_Intron	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	307					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				ACGTGGAAATCACACCCAACG	0.647000													17	26					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49206277	49206277	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:49206277G>A	ENST00000425340.2	+	2	181	c.64G>A	c.(64-66)Gtt>Att	p.V22I	FUT2_ENST00000391876.4_Missense_Mutation_p.V22I	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	22					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		TGTCTTTACGGTTTCCACTAT	0.517000													52	98					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814028	137814028	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr2:137814028G>T	ENST00000409968.1	+	3	356	c.178G>T	c.(178-180)Gga>Tga	p.G60*	THSD7B_ENST00000272643.3_Nonsense_Mutation_p.G60*|THSD7B_ENST00000413152.2_Nonsense_Mutation_p.G29*					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGGTCCCGGAGGAGTCCAGAG	0.493000													13	22					3.45872e-05	3.5129e-05	1	1	0
SLC9C1	285335	broad.mit.edu	37	3	111899464	111899464	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr3:111899464C>T	ENST00000305815.5	-	22	2947	c.2695G>A	c.(2695-2697)Gaa>Aaa	p.E899K	SLC9C1_ENST00000487372.1_Missense_Mutation_p.E851K	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	899					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										TCACCTTCTTCAAATATATCA	0.323000													17	21					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152328577	152328577	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr1:152328577C>T	ENST00000388718.5	-	3	1757	c.1685G>A	c.(1684-1686)aGa>aAa	p.R562K	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	562	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGATGTCTCTCTAGACCCATA	0.498000													78	133					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29637969	29637969	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:29637969G>A	ENST00000494692.1	+	6	611	c.611G>A	c.(610-612)gGa>gAa	p.G204E	MOG_ENST00000533330.2_Intron|MOG_ENST00000490427.1_Missense_Mutation_p.G88E|MOG_ENST00000376917.3_Intron|MOG_ENST00000431798.2_Intron|MOG_ENST00000483013.1_Intron|MOG_ENST00000376891.4_Intron|MOG_ENST00000376894.4_Intron|MOG_ENST00000396701.2_Intron|MOG_ENST00000396704.3_Missense_Mutation_p.G204E|MOG_ENST00000376888.2_Intron|MOG_ENST00000376898.3_Intron|MOG_ENST00000416766.2_Intron|MOG_ENST00000376902.3_Intron	NM_001008228.2|NM_206811.3	NP_001008229.1|NP_996534.2	Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	219					cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						GGTGTTCTAGGACCCCAGGTT	0.433000													11	47					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120832525	120832525	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr10:120832525G>A	ENST00000369144.3	-	4	545	c.418C>T	c.(418-420)Cgt>Tgt	p.R140C	EIF3A_ENST00000478852.1_Intron|EIF3A_ENST00000541549.1_Missense_Mutation_p.R106C	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	140					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		CTGTCAGTACGATCCTGAGTG	0.388000													13	10					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061307	9061307	+	Silent	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr19:9061307G>A	ENST00000397910.4	-	3	26342	c.26139C>T	c.(26137-26139)atC>atT	p.I8713I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8715	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.I8713I(2)|p.I4346I(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGAGGTACTGATCTCCCTTA	0.493000													12	19					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59514003	59514003	+	Splice_Site	SNP	C	C	G			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr8:59514003C>G	ENST00000038176.3	-	15	1429		c.e15+1		NSMAF_ENST00000427130.2_Splice_Site|NSMAF_ENST00000519858.1_Splice_Site	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor						ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				AAGAATCTTACCAATCCTAAC	0.388000													13	19					0	0	1	0	0
OR4A5	81318	broad.mit.edu	37	11	51411609	51411609	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr11:51411609G>A	ENST00000319760.6	-	1	839	c.787C>T	c.(787-789)Cct>Tct	p.P263S		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				TTATCAGTAGGAAAGTTTGAA	0.383000													6	24					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45670725	45670725	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr21:45670725C>A	ENST00000270172.3	-	10	1360	c.877G>T	c.(877-879)Gaa>Taa	p.E293*	DNMT3L_ENST00000418993.1_Nonsense_Mutation_p.E293*|AP001059.5_ENST00000442785.1_RNA	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	293					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		TCCAGGTCTTCCTTGTTCAGC	0.642000													27	70					4.72057e-08	4.83238e-08	1	1	0
DOPEY2	9980	broad.mit.edu	37	21	37603385	37603385	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr21:37603385C>T	ENST00000399151.3	+	14	2388	c.2303C>T	c.(2302-2304)tCc>tTc	p.S768F		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	768					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GTCTACCTGTCCGAGGAAGAG	0.612000													18	50					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112151249	112151252	+	Frame_Shift_Del	DEL	CACT	CACT	-	rs143341972		TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr5:112151249_112151252delCACT	ENST00000457016.1	+	9	1272_1275	c.892_895delCACT	c.(892-897)ctfs	p.HS298fs	APC_ENST00000257430.4_Frame_Shift_Del_p.HS298fs|APC_ENST00000508376.2_Frame_Shift_Del_p.HS298fs			P25054	APC_HUMAN	adenomatous polyposis coli	298	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.H298fs*28(1)|p.S299fs*27(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TAGTAGCACACACTCTGCACCTCG	0.407		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			14	9	---	---	---	---					
OR12D2	26529	broad.mit.edu	37	6	29364925	29364926	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr6:29364925_29364926insT	ENST00000383555.2	+	1	510_511	c.449_450insT	c.(448-450)gttfs	p.V150fs	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						TGGGTCATTGGTTTTTTCCATG	0.470													61	52	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396277	+	RNA	DEL	G	G	-	rs148140777	by1000genomes	TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr10:118396277delG	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTT	0.423													3	5	---	---	---	---					
KCNJ15	3772	broad.mit.edu	37	21	39672237	39672239	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-D9-A4Z6-01A-12D-A25O-08	TCGA-D9-A4Z6-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C277BDF0-AADC-41EE-B795-494857E3074A	673FC797-CDFC-4057-B767-5CF96672A66B	g.chr21:39672237_39672239delGAG	ENST00000398930.1	+	4	1408_1410	c.1054_1056delGAG	c.(1054-1056)del	p.E353del	KCNJ15_ENST00000398934.1_In_Frame_Del_p.E353del|KCNJ15_ENST00000398932.1_In_Frame_Del_p.E353del|KCNJ15_ENST00000328656.3_In_Frame_Del_p.E353del|KCNJ15_ENST00000398938.2_In_Frame_Del_p.E353del			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	353					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						ACAGCAACTCGAGGAGAAGTACA	0.443													25	29	---	---	---	---