Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ME1	4199	broad.mit.edu	37	6	84025070	84025070	+	Nonsense_Mutation	SNP	A	A	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:84025070A>C	ENST00000369705.3	-	6	779	c.663T>G	c.(661-663)taT>taG	p.Y221*	ME1_ENST00000543031.1_Nonsense_Mutation_p.Y146*|ME1_ENST00000541327.1_Nonsense_Mutation_p.Y55*	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	221					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AAAAATCATCATATTCAGAAC	0.299000													18	95					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202232	248202232	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:248202232C>T	ENST00000366479.2	+	1	759	c.663C>T	c.(661-663)ctC>ctT	p.L221L	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GCCGGGTTCTCCTTGCTGTCT	0.502000													35	228					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54952522	54952522	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:54952522C>T	ENST00000273286.5	-	3	1164	c.1002G>A	c.(1000-1002)gtG>gtA	p.V334V	CACNA2D3_ENST00000490478.1_Intron|CACNA2D3_ENST00000474759.1_Intron|LRTM1_ENST00000493075.1_Silent_p.V258V|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	334						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		CTTTTTCTTCCACCTTCCCAG	0.507000													31	194					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546473	11546473	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:11546473G>A	ENST00000389362.4	-	3	574	c.539C>T	c.(538-540)cCa>cTa	p.P180L	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGTCCTTGTGGCTTTCCTGG	0.592000													58	370					0	0	1	0	0
AREG	374	broad.mit.edu	37	4	75314928	75314928	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:75314928T>C	ENST00000395748.3	+	3	687	c.475T>C	c.(475-477)Tgc>Cgc	p.C159R	AREG_ENST00000502307.1_Missense_Mutation_p.C159R|AREG_ENST00000511560.1_3'UTR|AREG_ENST00000264487.2_Missense_Mutation_p.C159R	NM_001657.2	NP_001648.1	P15514	AREG_HUMAN	amphiregulin	159	EGF-like.				cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity			lung(4)	4			Lung(101;0.196)			TCACGGAGAATGCAAATATAT	0.338000													6	19					0	0	1	0	0
COQ2	27235	broad.mit.edu	37	4	84185424	84185424	+	Silent	SNP	G	G	A	rs6834269		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:84185424G>A	ENST00000311469.4	-	7	1193	c.1194C>T	c.(1192-1194)gtC>gtT	p.V398V	COQ2_ENST00000439031.2_Silent_p.V361V	NM_015697.7	NP_056512.5	Q96H96	COQ2_HUMAN	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	348					glycerol metabolic process|isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrial membrane	4-hydroxybenzoate decaprenyltransferase activity|4-hydroxybenzoate nonaprenyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)	8		Hepatocellular(203;0.114)				AATTCCCAAGGACAATCCCTA	0.323000													4	46					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810301	31810301	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:31810301C>T	ENST00000446923.2	+	7	2381	c.1990C>T	c.(1990-1992)Cct>Tct	p.P664S	ZEB1_ENST00000542815.3_Missense_Mutation_p.P613S|ZEB1_ENST00000320985.10_Missense_Mutation_p.P680S|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000361642.5_Missense_Mutation_p.P681S|ZEB1_ENST00000560721.2_Missense_Mutation_p.P660S	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	680					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TCTACAAAGTCCTTTGAAGAT	0.448000													9	74					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93026826	93026826	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:93026826G>A	ENST00000523629.1	-	4	903	c.449C>T	c.(448-450)aCc>aTc	p.T150I	RUNX1T1_ENST00000520724.1_Missense_Mutation_p.T113I|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.T113I|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.T123I|RUNX1T1_ENST00000521553.1_Missense_Mutation_p.T113I|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.T123I|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.T113I|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.T150I|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.T161I	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	150	TAFH.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CAGAACGAGGGTGCGAACTCT	0.502000													14	96					0	0	1	0	0
TTC25	83538	broad.mit.edu	37	17	40095264	40095264	+	RNA	SNP	A	A	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:40095264A>G	ENST00000591658.1	+	0	965							Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25							cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				AAGCTGAGAAAGTGCTGAAGA	0.507000													6	12					0	0	1	0	0
BCL2L12	83596	broad.mit.edu	37	19	50173529	50173529	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:50173529C>T	ENST00000246785.3	+	6	996	c.738C>T	c.(736-738)ttC>ttT	p.F246F	BCL2L12_ENST00000246784.3_3'UTR|BCL2L12_ENST00000441864.2_Silent_p.F245F	NM_001040668.1|NM_138639.1	NP_001035758.1|NP_619580.1	Q9HB09	B2L12_HUMAN	BCL2-like 12 (proline rich)	246					apoptosis					central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	8		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		CCGACTCTTTCGCCCGCCTGG	0.731000													3	14					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73731413	73731413	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:73731413C>T	ENST00000427855.1	+	22	3206	c.3104C>T	c.(3103-3105)tCa>tTa	p.S1035L	PAPLN_ENST00000381166.3_Missense_Mutation_p.S1035L|PAPLN_ENST00000554301.1_Missense_Mutation_p.S1035L|PAPLN_ENST00000340738.5_Missense_Mutation_p.S1008L|PAPLN_ENST00000555445.1_Missense_Mutation_p.S1019L			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	1035	Ig-like C2-type 2.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		ATCCCCTCTTCACACCCACAG	0.657000													31	99					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949342	27949342	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:27949342G>A	ENST00000379992.2	-	6	1777	c.1328C>T	c.(1327-1329)tCc>tTc	p.S443F	LINGO2_ENST00000308675.3_Missense_Mutation_p.S443F	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	443	Ig-like C2-type.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TGTCACCCAGGAAATCACAGG	0.532000													10	58					0	0	1	0	0
TTLL3	26140	broad.mit.edu	37	3	9862352	9862352	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:9862352G>A	ENST00000383827.1	+	1	2297	c.16G>A	c.(16-18)Gac>Aac	p.D6N	TTLL3_ENST00000455274.1_Missense_Mutation_p.D6N|TTLL3_ENST00000427853.3_Missense_Mutation_p.D6N|TTLL3_ENST00000547186.1_Missense_Mutation_p.D218N|ARPC4-TTLL3_ENST00000397256.1_Missense_Mutation_p.D279N|TTLL3_ENST00000426895.4_Missense_Mutation_p.D361N|TTLL3_ENST00000397241.1_Missense_Mutation_p.D6N|TTLL3_ENST00000430793.1_Missense_Mutation_p.D6N			Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	218					axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	Medulloblastoma(99;0.227)					CATCGACAAGGACCTGGAGGC	0.592000													15	77					0	0	1	0	0
CABP5	56344	broad.mit.edu	37	19	48537553	48537553	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:48537553C>T	ENST00000293255.2	-	5	545	c.415G>A	c.(415-417)Ggg>Agg	p.G139R		NM_019855.4	NP_062829.1	Q9NP86	CABP5_HUMAN	calcium binding protein 5	139	EF-hand 3.				signal transduction	cytoplasm	calcium ion binding			endometrium(1)|large_intestine(3)|lung(3)|prostate(2)|skin(2)	11		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)		AGCCGCTCCCCCAGGAGTCTC	0.537000													8	39					0	0	1	0	0
PRSS35	167681	broad.mit.edu	37	6	84233586	84233586	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:84233586C>T	ENST00000536636.1	+	3	771	c.426C>T	c.(424-426)ttC>ttT	p.F142F	PRSS35_ENST00000369700.3_Silent_p.F142F	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	142	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		TAACCAATTTCCCTTTCAGCA	0.468000													18	108					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20568969	20568969	+	Missense_Mutation	SNP	C	C	T	rs141844605		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:20568969C>T	ENST00000504154.1	+	27	3062	c.2810C>T	c.(2809-2811)cCa>cTa	p.P937L	SLIT2_ENST00000273739.5_Missense_Mutation_p.P941L|SLIT2_ENST00000503823.1_Missense_Mutation_p.P929L|SLIT2_ENST00000503837.1_Missense_Mutation_p.P933L	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	937	EGF-like 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AATAGTGATCCAGTTGACTTT	0.383000													27	170					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28935868	28935868	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:28935868G>A	ENST00000358201.4	-	2	718	c.130C>T	c.(130-132)Cgg>Tgg	p.R44W	RABEP2_ENST00000357573.6_Missense_Mutation_p.R44W|RABEP2_ENST00000561803.1_5'UTR|RABEP2_ENST00000544477.1_Intron	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	44					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						AGCTCAGCCCGAAGCCGGCTG	0.652000													6	52					0	0	1	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24895592	24895592	+	Missense_Mutation	SNP	G	G	A	rs146807462		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:24895592G>A	ENST00000382071.2	+	4	773	c.688G>A	c.(688-690)Gaa>Aaa	p.E230K	C1QTNF9_ENST00000332018.4_Missense_Mutation_p.E230K|C1QTNF9-AS1_ENST00000449656.1_RNA			P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	230	C1q.					collagen	hormone activity			endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		CCTGTATAACGAATTCAACCA	0.428000													21	193					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884615	24884615	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:24884615C>T	ENST00000382554.3	+	9	3978	c.3660C>T	c.(3658-3660)tcC>tcT	p.S1220S		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1220					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						AGCATTTTTCCCGCTGCATTG	0.632000													13	58					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138591807	138591807	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:138591807C>T	ENST00000440172.1	-	6	3366	c.3318G>A	c.(3316-3318)cgG>cgA	p.R1106R	KIAA1549_ENST00000242365.4_Silent_p.R1056R|KIAA1549_ENST00000422774.1_Silent_p.R1106R	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1106						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CCGGGCCCCGCCGAGGAGTCA	0.443000			O	BRAF	pilocytic astrocytoma								4	30					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73480163	73480163	+	Missense_Mutation	SNP	G	G	A	rs140028668		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:73480163G>A	ENST00000523207.1	+	2	782	c.194G>A	c.(193-195)cGa>cAa	p.R65Q		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	65					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GGGAAGCTTCGAGACTGCAAC	0.552000													14	78					0	0	1	0	0
SHC2	25759	broad.mit.edu	37	19	438991	438991	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:438991G>A	ENST00000264554.6	-	3	578	c.579C>T	c.(577-579)gtC>gtT	p.V193V		NM_012435.2	NP_036567.2	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing) transforming protein 2	193	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol				endometrium(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGATCCCCGGACGCCAGGCA	0.677000													3	5					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146471424	146471424	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:146471424C>T	ENST00000361727.3	+	2	675	c.159C>T	c.(157-159)tcC>tcT	p.S53S		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	53	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GCTCCTCCTCCATCTCTGGTA	0.423000										HNSCC(39;0.1)			6	30					0	0	1	0	0
RNF19B	127544	broad.mit.edu	37	1	33402511	33402511	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:33402511G>A	ENST00000373456.7	-	9	2094	c.2095C>T	c.(2095-2097)Ccc>Tcc	p.P699S	RNF19B_ENST00000356990.5_3'UTR|RNF19B_ENST00000235150.4_Missense_Mutation_p.P698S	NM_153341.2	NP_699172.2	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B	699						integral to membrane	ligase activity|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TGGGCTCTGGGGGTCGAGGGG	0.587000													28	104					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1617024	1617024	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:1617024C>T	ENST00000381580.1	-	3	638	c.459G>A	c.(457-459)ggG>ggA	p.G153G	SIRPG_ENST00000344103.4_Intron|SIRPG_ENST00000303415.3_Silent_p.G186G|RP11-77C3.3_ENST00000456177.1_RNA|SIRPG_ENST00000216927.4_Silent_p.G186G|SIRPG_ENST00000381583.2_Silent_p.G186G			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	186	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						AGAGCTCATTCCCATTTTTGA	0.577000													16	99					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84118606	84118606	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:84118606G>A	ENST00000372142.2	+	3	546	c.272G>A	c.(271-273)gGa>gAa	p.G91E	NRG3_ENST00000556918.1_Missense_Mutation_p.G142E|NRG3_ENST00000404576.2_Missense_Mutation_p.G116E|NRG3_ENST00000404547.1_Missense_Mutation_p.G312E|NRG3_ENST00000372141.2_Missense_Mutation_p.G312E	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	312					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		ACCCTGACCGGATCCCATAAA	0.557000													15	56					0	0	1	0	0
C1orf85	112770	broad.mit.edu	37	1	156264705	156264705	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:156264705G>A	ENST00000362007.1	-	2	249	c.223C>T	c.(223-225)Ctg>Ttg	p.L75L	C1orf85_ENST00000368264.1_Intron|C1orf85_ENST00000472870.1_5'UTR	NM_001256604.1|NM_001256609.1|NM_144580.2	NP_001243533.1|NP_001243538.1|NP_653181.1	Q8WWB7	NCUG1_HUMAN	chromosome 1 open reading frame 85	75					positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(2)|prostate(2)|skin(3)	14	Hepatocellular(266;0.158)					AGAGGCCCCAGGCTGCTCCAC	0.622000													7	100					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141771262	141771262	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:141771262C>T	ENST00000389484.3	-	14	3214	c.2243G>A	c.(2242-2244)gGa>gAa	p.G748E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	748					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACATAATTTCCATGATGCGA	0.378000										TSP Lung(27;0.18)			16	90					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140640956	140640956	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:140640956C>T	ENST00000509479.2	-	5	3794	c.2938G>A	c.(2938-2940)Gga>Aga	p.G980R	MGST2_ENST00000515137.1_Intron	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	976					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					TTGAATGGTCCCAATTCTCCA	0.577000													9	23					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38347784	38347784	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38347784C>T	ENST00000273173.4	+	1	358	c.267C>T	c.(265-267)ttC>ttT	p.F89F	SLC22A14_ENST00000448498.1_Silent_p.F89F	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	89						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CTGACCACTTCGTGTTCACAG	0.557000													19	77					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810809	7810809	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:7810809G>A	ENST00000315599.7	-	4	365	c.343C>T	c.(343-345)Cca>Tca	p.P115S	CD209_ENST00000315591.8_Missense_Mutation_p.P91S|CD209_ENST00000354397.6_Missense_Mutation_p.P115S|CD209_ENST00000601951.1_Missense_Mutation_p.P91S|CD209_ENST00000301357.8_Missense_Mutation_p.P71S|CD209_ENST00000601256.1_Missense_Mutation_p.P91S|CD209_ENST00000593660.1_Missense_Mutation_p.P91S|CD209_ENST00000602261.1_Missense_Mutation_p.P115S|CD209_ENST00000204801.8_Missense_Mutation_p.P71S|CD209_ENST00000593821.1_Missense_Mutation_p.P71S|CD209_ENST00000394161.5_Intron|CD209_ENST00000394173.4_Intron	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	115	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GATTTCTCTGGAAGCTCACCC	0.547000													29	185					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10296178	10296178	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:10296178C>T	ENST00000403437.2	-	37	5527	c.5433G>A	c.(5431-5433)ggG>ggA	p.G1811G	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1811					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCTGCTTCTTCCCACCCTTCA	0.567000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				25	165					0	0	1	0	0
ZC3H14	79882	broad.mit.edu	37	14	89068310	89068310	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:89068310C>T	ENST00000251038.5	+	11	1622	c.1397C>T	c.(1396-1398)tCa>tTa	p.S466L	ZC3H14_ENST00000556945.1_Intron|ZC3H14_ENST00000557607.1_Intron|ZC3H14_ENST00000393514.5_Missense_Mutation_p.S441L|ZC3H14_ENST00000555900.1_Missense_Mutation_p.S168L|ZC3H14_ENST00000555755.1_Missense_Mutation_p.S466L|ZC3H14_ENST00000359301.3_Intron|ZC3H14_ENST00000406216.3_Intron|ZC3H14_ENST00000336693.4_Intron|ZC3H14_ENST00000318308.6_Intron|ZC3H14_ENST00000302216.8_Intron	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	466						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						GACACAAGATCATTTATTCTG	0.423000													23	88					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80646595	80646595	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:80646595C>T	ENST00000466387.1	+	13	1883	c.1159C>T	c.(1159-1161)Cac>Tac	p.H387Y	CTNNA2_ENST00000496558.1_Missense_Mutation_p.H387Y|CTNNA2_ENST00000343114.3_Missense_Mutation_p.H66Y|CTNNA2_ENST00000541047.1_Missense_Mutation_p.H387Y|CTNNA2_ENST00000540488.1_Missense_Mutation_p.H387Y|CTNNA2_ENST00000402739.4_Missense_Mutation_p.H387Y|CTNNA2_ENST00000361291.4_Missense_Mutation_p.H421Y			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	387					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AGTGATGGATCACATATCTGA	0.348000													14	76					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33292889	33292889	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:33292889T>C	ENST00000280979.4	+	13	6040	c.5870T>C	c.(5869-5871)gTt>gCt	p.V1957A	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1957					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCCCAAGATGTTAGACATCTT	0.388000													20	82					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	90984815	90984815	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:90984815C>T	ENST00000268182.5	+	8	851	c.727C>T	c.(727-729)Ccg>Tcg	p.P243S	IQGAP1_ENST00000560738.1_Intron	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	243					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TTTGAAAAATCCGAATGCCAT	0.373000													10	76					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593051	179593051	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179593051C>T	ENST00000589042.1	-	67	19724	c.19500G>A	c.(19498-19500)atG>atA	p.M6500I	TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.M6183I|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.M5256I|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6183	Ig-like 46.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGCACTCCATATGAATAG	0.378000													7	35					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70900424	70900424	+	Silent	SNP	C	C	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:70900424C>G	ENST00000355733.3	-	15	2220	c.1776G>C	c.(1774-1776)ccG>ccC	p.P592P	ADD2_ENST00000407644.2_Intron|ADD2_ENST00000264436.3_Intron	NM_017488.3	NP_059522.1	P35612	ADDB_HUMAN	adducin 2 (beta)	0					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			autonomic_ganglia(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(11)|lung(13)|ovary(3)|pancreas(1)|skin(2)	36						CGCACACGGCCGGACCAGAGC	0.542000													9	64					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135263535	135263535	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:135263535A>G	ENST00000334270.2	-	8	2342	c.2303T>C	c.(2302-2304)cTt>cCt	p.L768P		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	768					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CCTTTCAATAAGGCTGACCTT	0.433000													6	71					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34002635	34002635	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:34002635G>A	ENST00000373381.4	-	62	10042	c.9866C>T	c.(9865-9867)tCt>tTt	p.S3289F		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3145						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTAGCCCTGAGAATTGTTCTG	0.517000													13	77					0	0	1	0	0
LOXL4	84171	broad.mit.edu	37	10	100017756	100017756	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:100017756C>T	ENST00000260702.3	-	7	1237	c.1087G>A	c.(1087-1089)Ggg>Agg	p.G363R		NM_032211.6	NP_115587.6	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4	363	SRCR 3.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(8)|ovary(4)|prostate(1)|skin(2)	26		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		AGCCGGGCCCCAAAGAGGGCC	0.642000													12	68					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951118	38951118	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:38951118C>T	ENST00000355481.4	+	20	2595	c.2464C>T	c.(2464-2466)Ctt>Ttt	p.L822F	RYR1_ENST00000360985.3_Missense_Mutation_p.L822F|RYR1_ENST00000359596.3_Missense_Mutation_p.L822F	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	822					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCGACTCCATCTTGAACCCAT	0.642000													17	100					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190585360	190585360	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:190585360C>T	ENST00000520309.1	+	12	2570	c.2482C>T	c.(2482-2484)Ctg>Ttg	p.L828L	ANKAR_ENST00000438402.2_Silent_p.L828L|ANKAR_ENST00000431575.2_Silent_p.L757L|ANKAR_ENST00000313581.4_Silent_p.L828L|ANKAR_ENST00000281412.6_Silent_p.L592L	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	828						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AATCCCAAGCCTGATAAATCT	0.284000													18	87					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13762882	13762882	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:13762882C>T	ENST00000265104.4	-	60	10334	c.10230G>A	c.(10228-10230)acG>acA	p.T3410T	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3410	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCATAGCTTTCGTCCAGGAAC	0.453000									Kartagener syndrome				14	74					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158624447	158624447	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:158624447G>A	ENST00000368148.3	-	21	3170	c.2990C>T	c.(2989-2991)aCc>aTc	p.T997I	SPTA1_ENST00000368147.3_Missense_Mutation_p.T997I	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	997	SH3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTTCTTCATGGTGACTTCTCG	0.468000													26	63					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33879634	33879634	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:33879634G>A	ENST00000374408.3	-	1	570	c.474C>T	c.(472-474)atC>atT	p.I158I		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	158										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GCAGGTCCTTGATGTTCTTGG	0.617000													26	75					0	0	1	0	0
APOA1	335	broad.mit.edu	37	11	116707050	116707050	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:116707050T>C	ENST00000236850.4	-	4	643	c.278A>G	c.(277-279)cAg>cGg	p.Q93R	APOA1_ENST00000375323.1_Missense_Mutation_p.Q93R|APOA1_ENST00000375329.2_Missense_Mutation_p.Q71R|APOA1_ENST00000359492.2_Missense_Mutation_p.Q93R|AP006216.12_ENST00000444200.1_RNA|APOA1_ENST00000375320.1_Missense_Mutation_p.Q93R	NM_000039.1	NP_000030.1	P02647	APOA1_HUMAN	apolipoprotein A-I	93	10 X approximate tandem repeats.				Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding			cervix(1)|endometrium(1)|lung(4)|prostate(1)|skin(2)	9	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CCAGAACTCCTGGGTCACAGG	0.587000													11	75					0	0	1	0	0
ANAPC7	51434	broad.mit.edu	37	12	110812092	110812092	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:110812092C>T	ENST00000455511.3	-	11	1657	c.1657G>A	c.(1657-1659)Gag>Aag	p.E553K	ANAPC7_ENST00000481473.1_5'UTR	NM_016238.2	NP_057322.2	Q9UJX3	APC7_HUMAN	anaphase promoting complex subunit 7	553					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)	19						TCCTCCTTCTCCATCTTCTGC	0.567000													8	46					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129417	6129417	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:6129417C>T	ENST00000316529.3	+	1	504	c.409C>T	c.(409-411)Cag>Tag	p.Q137*	RP11-290F24.3_ENST00000529961.1_RNA	NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCGCCCTCTTCAGTACCCCTC	0.488000													13	114					0	0	1	0	0
SYN1	6853	broad.mit.edu	37	X	47434645	47434645	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:47434645C>T	ENST00000295987.7	-	10	1311	c.1187G>A	c.(1186-1188)gGt>gAt	p.G396D	SYN1_ENST00000340666.4_Missense_Mutation_p.G396D	NM_006950.3	NP_008881.2	P17600	SYN1_HUMAN	synapsin I	396	C; actin-binding and synaptic-vesicle binding.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(6)|lung(6)|ovary(1)	21						CTGGTGGTCACCAATGAGCGG	0.627000													8	9					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167016129	167016129	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:167016129C>T	ENST00000392766.2	-	18	2183	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K	ZBBX_ENST00000392764.1_Missense_Mutation_p.E586K|ZBBX_ENST00000392767.2_Missense_Mutation_p.E615K|ZBBX_ENST00000307529.5_Missense_Mutation_p.E615K|ZBBX_ENST00000455345.2_Missense_Mutation_p.E615K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	615						intracellular	zinc ion binding	p.E615Q(2)		NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						TTGTTGCATTCTAAACGATGA	0.333000													20	90					0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19378093	19378093	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:19378093G>A	ENST00000550708.1	+	1	572	c.500G>A	c.(499-501)gGa>gAa	p.G167E		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGGGTTTGTGGATTTCTGTGG	0.488000													25	371					0	0	1	0	0
SLC25A19	60386	broad.mit.edu	37	17	73274394	73274394	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:73274394G>A	ENST00000402418.3	-	4	1391	c.482C>T	c.(481-483)gCc>gTc	p.A161V	SLC25A19_ENST00000375261.4_Missense_Mutation_p.A104V|SLC25A19_ENST00000320362.3_Missense_Mutation_p.A161V|SLC25A19_ENST00000580994.1_Missense_Mutation_p.A161V|SLC25A19_ENST00000442286.2_Missense_Mutation_p.A161V|SLC25A19_ENST00000416858.2_Missense_Mutation_p.A161V			Q9HC21	TPC_HUMAN	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	161						integral to membrane|mitochondrial inner membrane	binding|deoxynucleotide transmembrane transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_cancers(13;5.98e-08)|all_epithelial(9;1.16e-08)|Breast(9;3.1e-08)		all cancers(21;6.82e-07)|Epithelial(20;6.86e-06)			GGTCCCCACGGCGTGGCGCAG	0.562000													17	102					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151171225	151171225	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:151171225C>T	ENST00000282466.3	-	3	661	c.662G>A	c.(661-663)tGg>tAg	p.W221*		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	221	LRRCT.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATCACAGGTCCATGGGTTTCC	0.428000													21	105					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284299	159284299	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:159284299G>A	ENST00000332217.5	-	1	150	c.151C>T	c.(151-153)Cgc>Tgc	p.R51C		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					TGGTCCAGGCGAATAATGGTC	0.478000													50	151					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45795725	45795725	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:45795725C>T	ENST00000397928.1	+	6	1226	c.781C>T	c.(781-783)Ccc>Tcc	p.P261S	TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300481.9_Missense_Mutation_p.P261S|TRPM2_ENST00000300482.5_Missense_Mutation_p.P261S|TRPM2_ENST00000397932.2_Missense_Mutation_p.P261S	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	261						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GGGCAGCTTCCCCGCCGAGTA	0.607000													4	38					0	0	1	0	0
CLCA3P	9629	broad.mit.edu	37	1	87102522	87102522	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:87102522G>A	ENST00000456587.1	-	0	294				CLCA3P_ENST00000466454.1_RNA																							CTCCGGTGGGGAGTATTTGAT	0.368000													17	97					0	0	1	0	0
TDRD5	163589	broad.mit.edu	37	1	179603690	179603690	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:179603690C>T	ENST00000444136.1	+	8	1475	c.1225C>T	c.(1225-1227)Cct>Tct	p.P409S	TDRD5_ENST00000367614.1_Missense_Mutation_p.P409S|TDRD5_ENST00000294848.8_Missense_Mutation_p.P409S	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	409					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						ATGGAATTGCCCTTCAAAAAA	0.413000													46	127					0	0	1	0	0
LIN54	132660	broad.mit.edu	37	4	83857207	83857207	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:83857207G>A	ENST00000340417.3	-	11	2149	c.1772C>T	c.(1771-1773)tCt>tTt	p.S591F	LIN54_ENST00000506560.1_Missense_Mutation_p.S502F|LIN54_ENST00000505397.1_Missense_Mutation_p.S591F|LIN54_ENST00000446851.2_Missense_Mutation_p.S370F|LIN54_ENST00000442461.2_Missense_Mutation_p.S370F|LIN54_ENST00000395282.2_3'UTR|LIN54_ENST00000395283.2_Missense_Mutation_p.S502F|LIN54_ENST00000510557.1_Missense_Mutation_p.S370F	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	591					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.S591Y(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				ACGTCGATCAGATTCTCCCTC	0.403000													12	99					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			65	201					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32233067	32233067	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:32233067C>T	ENST00000400246.1	+	26	2422	c.2280C>T	c.(2278-2280)ttC>ttT	p.F760F	DEPDC5_ENST00000535622.1_Silent_p.F682F|DEPDC5_ENST00000400248.1_Silent_p.F751F|DEPDC5_ENST00000382105.2_Silent_p.F682F|DEPDC5_ENST00000400249.2_Silent_p.F751F|DEPDC5_ENST00000266091.3_Silent_p.F760F|DEPDC5_ENST00000382111.2_Silent_p.F760F|DEPDC5_ENST00000382112.3_Silent_p.F751F			O75140	DEPD5_HUMAN	DEP domain containing 5	751					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CCGACTACTTCCCTGACCGCC	0.557000													22	60					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89670141	89670141	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:89670141C>T	ENST00000264344.5	-	17	2330	c.2123G>A	c.(2122-2124)tGg>tAg	p.W708*	FAM13A_ENST00000513837.1_Nonsense_Mutation_p.W354*|FAM13A_ENST00000395002.2_Nonsense_Mutation_p.W382*|FAM13A_ENST00000508369.1_Nonsense_Mutation_p.W382*|FAM13A_ENST00000511976.1_Nonsense_Mutation_p.W294*|FAM13A_ENST00000503556.1_Nonsense_Mutation_p.W368*	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	708					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						GTCATTTGTCCATTTCAGAAC	0.468000													56	263					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10775926	10775926	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:10775926C>T	ENST00000283025.2	-	4	858	c.787G>A	c.(787-789)Gat>Aat	p.D263N		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	263					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						CACTTCTCATCGATACACTGG	0.537000													21	128					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19451521	19451521	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:19451521C>T	ENST00000396229.2	+	3	910	c.161C>T	c.(160-162)cCa>cTa	p.P54L	TMC5_ENST00000542583.2_Missense_Mutation_p.P54L|TMC5_ENST00000541464.1_Missense_Mutation_p.P54L|TMC5_ENST00000381414.4_Missense_Mutation_p.P54L	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	54						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AGGAGCAATCCATACTCTGTA	0.498000													18	98					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52474019	52474019	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:52474019G>A	ENST00000231721.2	-	11	1238	c.1239C>T	c.(1237-1239)ctC>ctT	p.L413L		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	413	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GCCAGAACATGAGGGGGTGGG	0.642000													20	73					0	0	1	0	0
C9orf173	441476	broad.mit.edu	37	9	140146528	140146528	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:140146528C>T	ENST00000388931.3	+	3	370	c.344C>T	c.(343-345)tCc>tTc	p.S115F	C9orf173_ENST00000412566.1_Missense_Mutation_p.S115F	NM_001004353.3|NM_001256699.1|NM_001256700.1|NM_001256701.1	NP_001004353.2|NP_001243628.1|NP_001243629.1|NP_001243630.1	Q8N7X2	CI173_HUMAN	chromosome 9 open reading frame 173	115										kidney(1)|large_intestine(1)|lung(5)|pancreas(1)	8						CCGAGCCCGTCCGTACGAGAG	0.672000													9	40					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45284596	45284596	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:45284596C>T	ENST00000270279.3	+	3	696	c.633C>T	c.(631-633)ttC>ttT	p.F211F	CBLC_ENST00000341505.4_Silent_p.F211F	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	211	Cbl-PTB.|EF-hand-like.				cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				TCTTCGAGTTCGACGTCTTCA	0.612000			M		AML								10	78					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107037521	107037521	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:107037521G>A	ENST00000273980.4	-	25	2697	c.2250C>T	c.(2248-2250)atC>atT	p.I750I	TBCK_ENST00000361687.4_Silent_p.I687I|TBCK_ENST00000394708.2_Silent_p.I750I|TBCK_ENST00000514689.1_5'UTR|TBCK_ENST00000394706.3_Silent_p.I711I|TBCK_ENST00000432496.2_Silent_p.I750I			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	750						intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						CATTTAATGGGATGGATTCTC	0.353000													12	46					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108868931	108868931	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:108868931C>T	ENST00000376700.1	+	2	283	c.283C>T	c.(283-285)Ccc>Tcc	p.P95S	SULT1C3_ENST00000329106.2_Missense_Mutation_p.P95S			Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	95						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						ACTGAAATTTCCCCATAAAGA	0.398000													10	60					0	0	1	0	0
THAP2	83591	broad.mit.edu	37	12	72070869	72070869	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:72070869C>A	ENST00000308086.2	+	3	2169	c.668C>A	c.(667-669)aCc>aAc	p.T223N	RP11-293I14.2_ENST00000548802.1_Intron	NM_031435.3	NP_113623.1	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated protein 2	223						nucleolus	DNA binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	10						CTAAAACAGACCAAGAGTACC	0.343000													10	47					1.58986e-06	1.61647e-06	1	1	0
COPG1	22820	broad.mit.edu	37	3	128987354	128987354	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:128987354C>T	ENST00000314797.6	+	17	1769	c.1665C>T	c.(1663-1665)atC>atT	p.I555I		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	555					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										CTGTGTCCATCCCTGGTCTGG	0.582000													13	50					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16863164	16863164	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:16863164C>T	ENST00000355661.3	-	9	812	c.802G>A	c.(802-804)Gag>Aag	p.E268K	PLEKHA7_ENST00000448080.2_Missense_Mutation_p.E268K|PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.E268K			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	268	PH.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TTCATGTCCTCCTGGGTGTCG	0.592000													12	80					0	0	1	0	0
OR5J2	282775	broad.mit.edu	37	11	55944143	55944143	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:55944143T>C	ENST00000312298.1	+	1	50	c.50T>C	c.(49-51)tTg>tCg	p.L17S		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					CTTTTGGGATTGACAGATCAT	0.358000													34	164					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137703363	137703363	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:137703363G>A	ENST00000371817.3	+	46	4022	c.3608G>A	c.(3607-3609)cGg>cAg	p.R1203Q		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1203	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCGGGGCCTCGGGGCCAGCAG	0.652000											OREG0019605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	16					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55439129	55439129	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:55439129G>A	ENST00000588756.1	-	12	3311	c.2825C>T	c.(2824-2826)tCc>tTc	p.S942F	NLRP7_ENST00000328092.5_Missense_Mutation_p.S914F|NLRP7_ENST00000340844.2_Intron|NLRP7_ENST00000448121.2_Missense_Mutation_p.S914F|NLRP7_ENST00000590030.1_Intron|NLRP7_ENST00000446217.1_Missense_Mutation_p.S970F|NLRP7_ENST00000592784.1_Missense_Mutation_p.S942F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	0							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AGGCATGAGGGAGCAGCTCCA	0.517000													14	123					0	0	1	0	0
ZNF649	65251	broad.mit.edu	37	19	52394203	52394203	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:52394203G>A	ENST00000354957.3	-	5	1470	c.1186C>T	c.(1186-1188)Cac>Tac	p.H396Y	CTC-429C10.2_ENST00000600329.1_RNA|ZNF649_ENST00000600738.1_Missense_Mutation_p.H368Y	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TCTCCTGAGTGAATTTTCTGA	0.443000													40	143					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196837173	196837173	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:196837173C>T	ENST00000312428.6	-	16	1951	c.1851G>A	c.(1849-1851)gtG>gtA	p.V617V		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	617	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CAGTTACCTCCACTTTCTGAA	0.408000													11	79					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154159698	154159698	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:154159698G>C	ENST00000360256.4	-	14	2567	c.2367C>G	c.(2365-2367)gaC>gaG	p.D789E		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	789	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CAAACCAAGGGTCAGTCTTCT	0.428000													43	107					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164772993	164772993	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:164772993C>T	ENST00000264382.3	-	13	1563	c.1501G>A	c.(1501-1503)Gga>Aga	p.G501R		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	501	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATCCAAAGTCCATCATATTGC	0.328000										HNSCC(35;0.089)			18	72					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90136492	90136492	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:90136492C>T	ENST00000405460.2	+	78	16805	c.16709C>T	c.(16708-16710)cCt>cTt	p.P5570L	GPR98_ENST00000425867.2_Missense_Mutation_p.P1231L	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5570					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTCTTTGAACCTGGCCAGAGA	0.418000													25	127					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23894592	23894592	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:23894592C>T	ENST00000355349.3	-	21	2484	c.2322G>A	c.(2320-2322)gaG>gaA	p.E774E		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	774	Myosin head-like.		E -> V (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CCCTCATTTCCTCCAGCAGCC	0.587000													6	48					0	0	1	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1717360	1717360	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:1717360C>T	ENST00000397412.3	+	17	3160	c.3061C>T	c.(3061-3063)Cct>Tct	p.P1021S	LA16c-431H6.6_ENST00000454337.1_3'UTR|CRAMP1L_ENST00000436138.3_Missense_Mutation_p.P1018S|CRAMP1L_ENST00000293925.5_Missense_Mutation_p.P1021S|CRAMP1L_ENST00000262317.4_Missense_Mutation_p.P399S			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	1021						nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						TGTCAGCATCCCTTCGAGGCC	0.627000													4	42					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116975512	116975512	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:116975512G>A	ENST00000355044.3	+	9	1532	c.1406G>A	c.(1405-1407)gGc>gAc	p.G469D		NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	469						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GGTGGATATGGCCATACTAGT	0.333000													5	41					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137671975	137671975	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:137671975G>A	ENST00000371817.3	+	28	2827	c.2413G>A	c.(2413-2415)Ggc>Agc	p.G805S		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	805	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGGTCTGAAGGGCACAAAGGG	0.592000													19	111					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21228996	21228996	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:21228996C>T	ENST00000233242.1	-	26	10871	c.10744G>A	c.(10744-10746)Gaa>Aaa	p.E3582K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3582					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTGTATGTTCTCCGTTGGTG	0.483000													7	66					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17428260	17428260	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:17428260C>T	ENST00000302539.4	-	26	3366	c.3241G>A	c.(3241-3243)Gtc>Atc	p.V1081I	ABCC8_ENST00000389817.3_Missense_Mutation_p.V1080I	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1080	ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACAGACGTGACGAGGCACAGC	0.587000													9	70					0	0	1	0	0
HS3ST2	9956	broad.mit.edu	37	16	22926815	22926815	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:22926815C>T	ENST00000261374.3	+	2	1470	c.1036C>T	c.(1036-1038)Cga>Tga	p.R346*		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	346						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		AGACCAGCTCCGAGAATTTTA	0.443000													39	191					0	0	1	0	0
TTF1	7270	broad.mit.edu	37	9	135277532	135277532	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:135277532G>A	ENST00000334270.2	-	2	716	c.677C>T	c.(676-678)tCc>tTc	p.S226F		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	226					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CCGGTTACTGGACTTTTTCTT	0.502000													8	46					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6651132	6651132	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:6651132G>A	ENST00000299441.3	-	11	5217	c.4806C>T	c.(4804-4806)tcC>tcT	p.S1602S		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1602	Cadherin 15.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCGCACCACGGACAGCGCTC	0.652000													7	31					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879284	144879284	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:144879284G>A	ENST00000369359.4	-	30	4612	c.4574C>T	c.(4573-4575)tCg>tTg	p.S1525L	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S1389L|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S1389L|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S1525L|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S1345L			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1389					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAGACTAGACGAATAATCACT	0.517000			T	PDGFRB	MPD								33	226					0	0	1	0	0
COQ3	51805	broad.mit.edu	37	6	99817684	99817684	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:99817684A>G	ENST00000254759.3	-	7	926	c.902T>C	c.(901-903)gTt>gCt	p.V301A	COQ3_ENST00000369240.1_Missense_Mutation_p.V73A|COQ3_ENST00000369242.1_Missense_Mutation_p.V73A	NM_017421.3	NP_059117.3	Q9NZJ6	COQ3_HUMAN	coenzyme Q3 methyltransferase	301					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			cervix(1)|lung(5)|upper_aerodigestive_tract(2)	8		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		CACTGTTTGAACTGACAGACC	0.348000													22	119					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99799824	99799824	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:99799824C>T	ENST00000426455.1	+	24	2831	c.2424C>T	c.(2422-2424)ctC>ctT	p.L808L	STAG3_ENST00000317296.5_Silent_p.L808L|GATS_ENST00000543273.1_RNA|STAG3_ENST00000440830.1_3'UTR|GATS_ENST00000436886.2_3'UTR|STAG3_ENST00000394018.2_Silent_p.L750L			Q9UJ98	STAG3_HUMAN	stromal antigen 3	808					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATCTACTTCTCATCTTTAGCC	0.428000													41	201					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833041	24833041	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:24833041G>A	ENST00000376451.2	+	14	4151	c.3891G>A	c.(3889-3891)ctG>ctA	p.L1297L	KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000376454.3_Silent_p.L1614L			Q5T5P2	SKT_HUMAN	KIAA1217	1614					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						ATGGCACCCTGAAACAGCACA	0.512000													15	70					0	0	1	0	0
TCTE1	202500	broad.mit.edu	37	6	44255445	44255445	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:44255445G>A	ENST00000371505.4	-	2	240	c.118C>T	c.(118-120)Cct>Tct	p.P40S	TCTE1_ENST00000371503.3_5'UTR|TMEM151B_ENST00000438774.2_Intron	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	40										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTGATTGAAGGCTTTGAGAGC	0.557000													13	66					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61513264	61513264	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:61513264G>A	ENST00000266070.4	-	16	4369	c.4044C>T	c.(4042-4044)acC>acT	p.T1348T	DIDO1_ENST00000395343.1_Silent_p.T1348T	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1348					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CCTCTGCTGTGGTTTTGGGCT	0.577000													20	110					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99312238	99312238	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:99312238T>C	ENST00000336374.2	-	8	740	c.738A>G	c.(736-738)atA>atG	p.I246M		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	246					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					TTAGAAAACTTATAACTTTTC	0.333000													12	72					0	0	1	0	0
OR51A7	119687	broad.mit.edu	37	11	4928871	4928871	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:4928871G>A	ENST00000359350.4	+	1	272	c.272G>A	c.(271-273)gGa>gAa	p.G91E	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AATGCCATGGGAATTTCACCT	0.448000													20	129					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23316063	23316063	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:23316063G>A	ENST00000560464.1	-	0	2876																											TAAAGTCTTGGTGGCTTCACT	0.498000													16	112					0	0	1	0	0
LOXL1	4016	broad.mit.edu	37	15	74239560	74239560	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:74239560C>T	ENST00000261921.7	+	4	1828	c.1502C>T	c.(1501-1503)aCc>aTc	p.T501I		NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	501	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						ACCTCTCATACCCAGGTTGGG	0.612000													7	60					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173596225	173596225	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:173596225C>T	ENST00000333279.2	-	4	630	c.570G>A	c.(568-570)ggG>ggA	p.G190G		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	206										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						TAAGGAGTTTCCCTGATCCCT	0.353000													21	145					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183099217	183099217	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:183099217C>T	ENST00000435564.1	-	4	607	c.407G>A	c.(406-408)cGa>cAa	p.R136Q	PDE1A_ENST00000410103.1_Missense_Mutation_p.R136Q|PDE1A_ENST00000409365.1_Missense_Mutation_p.R120Q|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000358139.2_Missense_Mutation_p.R136Q|PDE1A_ENST00000351439.5_Missense_Mutation_p.R120Q|PDE1A_ENST00000331935.6_Missense_Mutation_p.R136Q|PDE1A_ENST00000536095.1_Missense_Mutation_p.R32Q|PDE1A_ENST00000346717.4_Missense_Mutation_p.R102Q|PDE1A_ENST00000456212.1_Missense_Mutation_p.R136Q	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	136					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ATATGTTTTTCGGTACATTCT	0.269000													12	81					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52257502	52257502	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:52257502G>A	ENST00000597542.1	-	9	1859	c.902C>T	c.(901-903)cCc>cTc	p.P301L	TLR9_ENST00000494383.1_Silent_p.S430S|TLR9_ENST00000360658.2_Missense_Mutation_p.P277L			Q9NR96	TLR9_HUMAN	toll-like receptor 9	277					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GAAGGTATCGGGATGTAGCTG	0.617000													8	39					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	621259	621259	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:621259G>A	ENST00000588649.2	-	10	2523	c.2439C>T	c.(2437-2439)ttC>ttT	p.F813F		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	813	Mediates interaction with TEFM.				transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGTGGTTGAAGTGCGGCG	0.711000													4	20					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423569	26423569	+	Silent	SNP	C	C	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:26423569C>A	ENST00000335473.7	+	43	7879	c.7629C>A	c.(7627-7629)ccC>ccA	p.P2543P	MYO18B_ENST00000407587.2_Silent_p.P2544P|MYO18B_ENST00000536101.1_Silent_p.P2543P	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2543						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GAACGTCCCCCGAGCGGAGAG	0.552000													7	18					2.0095e-06	2.04028e-06	1	1	0
TGM5	9333	broad.mit.edu	37	15	43525827	43525827	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:43525827G>A	ENST00000220420.5	-	12	1941	c.1934C>T	c.(1933-1935)cCc>cTc	p.P645L	TGM5_ENST00000349114.4_Missense_Mutation_p.P563L	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	645					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	CTCCGAGAGGGGGTTTGAAAA	0.502000													13	65					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129679332	129679332	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:129679332G>A	ENST00000358303.4	-	4	549	c.465C>T	c.(463-465)ttC>ttT	p.F155F	ZC3HC1_ENST00000360708.5_Silent_p.F155F|ZC3HC1_ENST00000311873.5_Silent_p.F134F|ZC3HC1_ENST00000481503.1_Silent_p.F155F	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	155					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					GCCAGAAACAGAACTTCTCAT	0.393000													6	56					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86228062	86228062	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:86228062C>T	ENST00000394518.2	+	16	5342	c.5247C>T	c.(5245-5247)ttC>ttT	p.F1749F	AKAP13_ENST00000394510.2_5'UTR|AKAP13_ENST00000361243.2_Silent_p.F1753F|AKAP13_ENST00000560579.1_3'UTR	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1749					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GTCGTACATTCAGCTACATCA	0.408000													31	149					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57192207	57192207	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:57192207C>T	ENST00000343433.6	-	16	1923	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K		NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	615										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TCTTTTTTTTCCTTTGGTGTC	0.353000													40	98					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41323714	41323714	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:41323714G>A	ENST00000551295.2	+	7	730	c.613G>A	c.(613-615)Gac>Aac	p.D205N	CNTN1_ENST00000348761.2_Missense_Mutation_p.D194N|CNTN1_ENST00000360099.3_Missense_Mutation_p.D205N|CNTN1_ENST00000347616.1_Missense_Mutation_p.D205N|CNTN1_ENST00000547849.1_Missense_Mutation_p.D205N|CNTN1_ENST00000547702.1_Missense_Mutation_p.D205N	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	205	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGAGGCTTCCGACAAAGGCAA	0.388000													26	152					0	0	1	0	0
LMAN2	10960	broad.mit.edu	37	5	176764726	176764726	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:176764726G>A	ENST00000303127.7	-	4	698	c.494C>T	c.(493-495)cCc>cTc	p.P165L	LMAN2_ENST00000506310.1_5'UTR|LMAN2_ENST00000515209.1_Missense_Mutation_p.P165L	NM_006816.2	NP_006807.1	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2	165	Carbohydrate binding (By similarity).|L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTCATCATTGGGGTAGGTGTC	0.537000													9	22					0	0	1	0	0
IFIT3	3437	broad.mit.edu	37	10	91099395	91099395	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:91099395C>T	ENST00000371818.4	+	2	1163	c.983C>T	c.(982-984)cCt>cTt	p.P328L	LIPA_ENST00000371837.1_Intron|IFIT3_ENST00000371811.4_Missense_Mutation_p.P328L|LIPA_ENST00000487618.1_Intron	NM_001549.4	NP_001540.2	O14879	IFIT3_HUMAN	interferon-induced protein with tetratricopeptide repeats 3	328					type I interferon-mediated signaling pathway		protein binding			breast(1)|central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)|urinary_tract(1)	15						GGACTGAATCCTCTGAATGCA	0.418000													12	95					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48919445	48919445	+	Missense_Mutation	SNP	G	G	A	rs140344146	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:48919445G>A	ENST00000310194.1	+	1	31	c.31G>A	c.(31-33)Gag>Aag	p.E11K	OR8S1_ENST00000551654.1_Intron	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						CACCATCACCGAGTTCCTCCT	0.493000													25	138					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151163907	151163907	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:151163907C>T	ENST00000282466.3	-	4	3861	c.3862G>A	c.(3862-3864)Gag>Aag	p.E1288K		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1288					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGGGAAGCTCCTTCTTTGTT	0.423000													36	185					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612942	179612942	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179612942A>G	ENST00000360870.5	-	46	14407	c.14185T>C	c.(14185-14187)Tat>Cat	p.Y4729H	TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	840	Ig-like 27.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTCACTATAGATTTCTTCA	0.343000													13	58					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152697632	152697632	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:152697632G>A	ENST00000367255.5	-	58	9809	c.9208C>T	c.(9208-9210)Cga>Tga	p.R3070*	SYNE1_ENST00000265368.4_Nonsense_Mutation_p.R3070*|SYNE1_ENST00000423061.1_Nonsense_Mutation_p.R3077*|SYNE1_ENST00000341594.5_Nonsense_Mutation_p.R3109*|SYNE1_ENST00000448038.1_Nonsense_Mutation_p.R3077*	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3070					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGGCCTTTCGAAATCTTTGC	0.388000										HNSCC(10;0.0054)			18	57					0	0	1	0	0
PPBPP2	10895	broad.mit.edu	37	4	74919860	74919860	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:74919860G>A	ENST00000513150.1	-	0	1256					NR_026769.1																						CTGCAAGAGAGAATAGAATTA	0.448000													6	24					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49740122	49740122	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:49740122C>T	ENST00000327697.6	+	20	1830	c.1686C>T	c.(1684-1686)atC>atT	p.I562I	RNF123_ENST00000432042.1_Silent_p.I416I	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	562						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		ACCGGCTGATCTCTGCCCTGC	0.562000													35	226					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89156773	89156773	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:89156773G>A	ENST00000452230.1	-	0	39				IGKC_ENST00000390237.2_RNA|AC096579.7_ENST00000430694.1_RNA																							TGAGCTGGAGGACCGCAATAG	0.527000													3	8					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40398385	40398385	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:40398385G>A	ENST00000221347.6	-	14	6589	c.6582C>T	c.(6580-6582)ttC>ttT	p.F2194F		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2194	VWFD 5.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCAGGCGCACGAAGCTGTCCC	0.682000													16	42					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029714	150029714	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:150029714C>T	ENST00000394243.1	+	3	2983	c.2609C>T	c.(2608-2610)tCc>tTc	p.S870F	SYNPO_ENST00000519664.1_Missense_Mutation_p.S626F|SYNPO_ENST00000307662.4_Missense_Mutation_p.S626F|SYNPO_ENST00000522122.1_Missense_Mutation_p.S870F	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	870	Pro-rich.				positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCTACACCTCCCCCGGCCAG	0.706000													24	96					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27017171	27017171	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:27017171G>A	ENST00000314616.6	+	26	3697	c.3414G>A	c.(3412-3414)cgG>cgA	p.R1138R	SUPT6H_ENST00000347486.4_Silent_p.R1138R	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1138					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					AGGACCTCCGGACAGCCTACC	0.473000													26	94					0	0	1	0	0
IGHV1-3	28473	broad.mit.edu	37	14	106471457	106471457	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:106471457G>A	ENST00000390595.2	-	0	181																											GCTAGTGAAGGTGTATCCAGA	0.547000													17	144					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143056427	143056427	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:143056427G>A	ENST00000409408.1	-	3	1884	c.176C>T	c.(175-177)tCa>tTa	p.S59L	FAM131B_ENST00000409222.3_Missense_Mutation_p.S59L|FAM131B_ENST00000443739.2_Missense_Mutation_p.S87L|FAM131B_ENST00000409578.1_Missense_Mutation_p.S75L|FAM131B_ENST00000409346.1_Missense_Mutation_p.S59L			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	59										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					ACCTGAGAATGATGACTTGGC	0.502000													3	17					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745193	140745193	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140745193C>T	ENST00000518069.1	+	1	1296	c.1296C>T	c.(1294-1296)ctC>ctT	p.L432L	PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCCGCCCCTCTCTACAGAAA	0.448000													25	96					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54364889	54364889	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:54364889G>A	ENST00000306888.2	-	4	860	c.609C>T	c.(607-609)gtC>gtT	p.V203V	FIP1L1_ENST00000507166.1_Intron|LNX1_ENST00000263925.7_Silent_p.V299V|LNX1-AS1_ENST00000502373.1_RNA	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	299						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TAATGATATGGACCAGTGGGG	0.493000													9	51					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109959293	109959293	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:109959293C>T	ENST00000342494.3	+	21	2896	c.2301C>T	c.(2299-2301)atC>atT	p.I767I	UBE3B_ENST00000434735.2_Silent_p.I767I	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	767	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CATCCTACATCCATGAGAATT	0.493000													9	47					0	0	1	0	0
GTPBP1	9567	broad.mit.edu	37	22	39112055	39112055	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:39112055C>T	ENST00000216044.5	+	3	681	c.448C>T	c.(448-450)Cgg>Tgg	p.R150W		NM_004286.4	NP_004277.2	O00178	GTPB1_HUMAN	GTP binding protein 1	150					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	18	Melanoma(58;0.04)					TTACCTGGTCCGGAAACGAGT	0.582000													5	23					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77359804	77359804	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:77359804C>T	ENST00000282849.5	-	13	2409	c.1991G>A	c.(1990-1992)cGt>cAt	p.R664H		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	664	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GAACCATCCACGGAAAGGTTT	0.388000													17	79					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57921906	57921906	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:57921906G>A	ENST00000564448.1	-	32	3357	c.3297C>T	c.(3295-3297)acC>acT	p.T1099T	CNGB1_ENST00000251102.8_Silent_p.T1105T			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	1105					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						AGAGCTTTGGGGTGCCCGCCC	0.582000													11	89					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179720083	179720083	+	Silent	SNP	C	C	T	rs76860661		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179720083C>T	ENST00000420890.2	-	19	3168	c.3051G>A	c.(3049-3051)gtG>gtA	p.V1017V	CCDC141_ENST00000295723.5_Silent_p.V442V	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	442							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCTCTTCTATCACCTCCTGGA	0.358000													13	60					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104577352	104577352	+	Splice_Site	SNP	T	T	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:104577352T>G	ENST00000304883.2	-	3	1027	c.888_splice	c.e3+1	p.K296_splice		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	296						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GACCAGTACCTTTCTTTTGGC	0.388000													12	100					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	170139862	170139862	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:170139862C>T	ENST00000411494.1	+	2	66	c.66C>T	c.(64-66)atC>atT	p.I22I	KCNIP1_ENST00000520740.1_Intron|KCNIP1_ENST00000434108.1_Intron|KCNIP1_ENST00000390656.4_Intron|KCNIP1_ENST00000328939.4_Intron|KCNIP1_ENST00000377360.4_Intron			Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	22					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity	p.I22I(1)		autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTAGACATCGCCTGGTGGT	0.413000													18	81					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101481355	101481355	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:101481355G>A	ENST00000341893.3	+	10	2596	c.1844G>A	c.(1843-1845)cGt>cAt	p.R615H	CEP97_ENST00000494050.1_Missense_Mutation_p.R556H|CEP97_ENST00000327230.4_Missense_Mutation_p.R615H			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	615	CEP110 binding.					centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						GATGAAGAACGTATTAAAAAA	0.333000													9	72					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30128480	30128480	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:30128480C>T	ENST00000449742.2	-	1	231	c.156G>A	c.(154-156)gaG>gaA	p.E52E	TRIM10_ENST00000376704.3_Silent_p.E52E	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	52						cytoplasm	zinc ion binding			ovary(1)	1						TAGGGGACTCCTCCAGGTCTG	0.622000													23	180					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118202630	118202630	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:118202630C>T	ENST00000369230.3	+	3	414	c.268C>T	c.(268-270)Cgt>Tgt	p.R90C		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	90					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		CAAGATCACCCGTATCAACAT	0.388000													10	47					0	0	1	0	0
IQCE	23288	broad.mit.edu	37	7	2617906	2617906	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:2617906C>T	ENST00000402050.2	+	7	680	c.496C>T	c.(496-498)Ctg>Ttg	p.L166L	IQCE_ENST00000404984.1_Silent_p.L115L|IQCE_ENST00000325979.7_Silent_p.L101L|IQCE_ENST00000438376.2_Silent_p.L150L	NM_001100390.1|NM_152558.3	NP_001093860.1|NP_689771.3	Q6IPM2	IQCE_HUMAN	IQ motif containing E	166										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CGACGTGGACCTGATGAGAAC	0.612000													7	51					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23316062	23316062	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:23316062G>A	ENST00000560464.1	-	0	2877																											ATAAAGTCTTGGTGGCTTCAC	0.502000													16	112					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33046326	33046326	+	Splice_Site	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:33046326G>A	ENST00000280979.4	+	5	2517	c.2346_splice	c.e5-1	p.G783_splice	AKAP6_ENST00000557272.1_Splice_Site_p.G783_splice|AKAP6_ENST00000557354.1_Splice_Site_p.G783_splice	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	783					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTTTCACAAGGGGTTTGTAAA	0.358000													15	68					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8587371	8587371	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:8587371G>A	ENST00000338257.8	-	27	3377	c.3110C>T	c.(3109-3111)cCc>cTc	p.P1037L		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	1037						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CCGAGGCTGGGGCTTGGGTCG	0.632000													3	18					0	0	1	0	0
C10orf120	399814	broad.mit.edu	37	10	124457674	124457674	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:124457674G>A	ENST00000329446.4	-	3	614	c.583C>T	c.(583-585)Ctg>Ttg	p.L195L		NM_001010912.1	NP_001010912.1	Q5SQS8	CJ120_HUMAN	chromosome 10 open reading frame 120	195										endometrium(1)|kidney(1)|large_intestine(6)|lung(9)|skin(2)|stomach(1)|urinary_tract(1)	21		all_neural(114;0.169)|Glioma(114;0.222)				ACCCCAGACAGAAATGAGGAG	0.473000													11	67					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169699657	169699657	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:169699657C>T	ENST00000333360.7	-	5	770	c.631G>A	c.(631-633)Gat>Aat	p.D211N	SELE_ENST00000367779.4_Missense_Mutation_p.D211N|SELE_ENST00000367781.4_Missense_Mutation_p.D211N|SELE_ENST00000367780.4_Intron|SELE_ENST00000367775.1_Intron|SELE_ENST00000367777.1_Missense_Mutation_p.D211N|SELE_ENST00000367776.1_Missense_Mutation_p.D211N|SELE_ENST00000367774.1_Missense_Mutation_p.D211N|SELE_ENST00000367782.4_Missense_Mutation_p.D211N|C1orf112_ENST00000498289.1_Intron	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	211	Sushi 1.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					TAACCCCTATCACAGCTGATA	0.512000													26	68					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98660391	98660391	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:98660391C>T	ENST00000261574.5	+	18	2029	c.1849C>T	c.(1849-1851)Cct>Tct	p.P617S	IPO5_ENST00000539640.1_Missense_Mutation_p.P474S|IPO5_ENST00000490680.1_Missense_Mutation_p.P599S	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	599					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						AGATGATGATCCTCAGGTAAG	0.383000													9	60					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52523558	52523558	+	Missense_Mutation	SNP	C	C	T	rs146356041		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:52523558C>T	ENST00000345716.4	+	17	3454	c.3320C>T	c.(3319-3321)cCg>cTg	p.P1107L	NISCH_ENST00000479054.1_Missense_Mutation_p.P1107L	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	1107					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		gcccAGTACCCGAGTGAGCAC	0.687000													8	50					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162508649	162508649	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:162508649C>T	ENST00000306100.5	-	8	1409	c.973G>A	c.(973-975)Ggc>Agc	p.G325S	FSTL5_ENST00000379164.4_Missense_Mutation_p.G324S|FSTL5_ENST00000511170.1_5'UTR|FSTL5_ENST00000427802.2_Missense_Mutation_p.G324S|FSTL5_ENST00000536695.1_Missense_Mutation_p.G324S	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	325	Ig-like 1.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TGTTCATAGCCATCTGCATAG	0.358000													12	95					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113246681	113246681	+	Silent	SNP	G	G	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:113246681G>T	ENST00000297405.5	-	68	10897	c.10653C>A	c.(10651-10653)cgC>cgA	p.R3551R	CSMD3_ENST00000352409.3_Silent_p.R3481R|CSMD3_ENST00000455883.2_Silent_p.R3382R|CSMD3_ENST00000343508.3_Silent_p.R3511R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3551						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTAACATTAGGCGAGCTTCCT	0.328000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	152					1.00025e-24	1.02269e-24	1	1	0
PKHD1	5314	broad.mit.edu	37	6	51497504	51497504	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:51497504G>A	ENST00000371117.3	-	65	11799	c.11524C>T	c.(11524-11526)Cga>Tga	p.R3842*		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3842			R -> L.		cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GGCTTGGATCGAGCTGTAAAA	0.423000													10	65					0	0	1	0	0
GOLGA2P5	55592	broad.mit.edu	37	12	100550368	100550368	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:100550368C>T	ENST00000397112.4	-	0	2453					NR_036632.1															large_intestine(1)|lung(3)	4						GCCCCACTTCCCCAGGTTTTG	0.527000													9	24					0	0	1	0	0
ATP5O	539	broad.mit.edu	37	21	35281510	35281510	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:35281510G>A	ENST00000429238.1	-	2	48	c.49C>T	c.(49-51)Cct>Tct	p.P17S	ATP5O_ENST00000290299.2_Silent_p.I68I																							GTTCCTTCAGGATTTGCTGAA	0.368000													16	87					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26431764	26431764	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:26431764C>T	ENST00000466808.2	+	0	1712																											TTTAGTAGTTCCTTTGGTTGT	0.502000													25	134					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124332563	124332563	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:124332563C>T	ENST00000409039.3	+	32	5541	c.5516C>T	c.(5515-5517)aCc>aTc	p.T1839I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1839	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACCGGCAAAACCGAGACCACC	0.552000													28	103					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160742967	160742967	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:160742967C>T	ENST00000263636.4	-	5	904	c.877G>A	c.(877-879)Gac>Aac	p.D293N	LY75-CD302_ENST00000505052.1_Missense_Mutation_p.D293N|LY75_ENST00000553424.1_Missense_Mutation_p.D293N|LY75_ENST00000554112.1_Missense_Mutation_p.D293N|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.D293N	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		GGTTTGTGGTCTGACCATTCC	0.378000													16	71					0	0	1	0	0
ITGB7	3695	broad.mit.edu	37	12	53588086	53588086	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:53588086G>A	ENST00000267082.5	-	10	1435	c.1204C>T	c.(1204-1206)Cct>Tct	p.P402S	ITGB7_ENST00000422257.3_Missense_Mutation_p.P402S|ITGB7_ENST00000550743.2_Missense_Mutation_p.P402S|ITGB7_ENST00000338737.4_Missense_Mutation_p.P402S	NM_000889.1	NP_000880.1	P26010	ITB7_HUMAN	integrin, beta 7	402					cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			NS(2)|breast(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGGACCCCAGGAGGGAGTGAA	0.547000													16	62					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106968940	106968940	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:106968940C>T	ENST00000369066.3	+	2	3120	c.2633C>T	c.(2632-2634)cCc>cTc	p.P878L		NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	878							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		GTGTCACAGCCCACGACTGAG	0.468000													13	90					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647898	121647898	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:121647898C>T	ENST00000489711.1	+	16	1799	c.1411C>T	c.(1411-1413)Cac>Tac	p.H471Y	SLC15A2_ENST00000465060.1_3'UTR|SLC15A2_ENST00000295605.2_Missense_Mutation_p.H440Y	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	471					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CCTGAAATATCACAATTTGTC	0.388000													36	193					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54802730	54802730	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:54802730G>A	ENST00000391745.1	-	9	1078	c.762C>T	c.(760-762)gcC>gcT	p.A254A	LILRA3_ENST00000391744.3_Silent_p.A173A|LILRA3_ENST00000251390.3_Silent_p.A237A					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTCCCCAGGGGCCACGACAG	0.597000													10	52					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50958944	50958944	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:50958944G>A	ENST00000374103.4	-	7	922	c.837C>T	c.(835-837)acC>acT	p.T279T	OGDHL_ENST00000419399.1_Silent_p.T222T|OGDHL_ENST00000432695.1_Silent_p.T70T	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	279					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TGTCGATGATGGTCTTGAGGG	0.562000													5	20					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692539	135692539	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:135692539G>A	ENST00000513104.1	-	2	819	c.537C>T	c.(535-537)atC>atT	p.I179I	TRPC7_ENST00000426057.2_Silent_p.I179I|TRPC7_ENST00000355180.3_Silent_p.I179I	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	179					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGATGTGCACGATCTCATACT	0.607000													18	73					0	0	1	0	0
SORT1	6272	broad.mit.edu	37	1	109893608	109893608	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:109893608G>A	ENST00000256637.6	-	6	783	c.725C>T	c.(724-726)tCc>tTc	p.S242F	SORT1_ENST00000538502.1_Missense_Mutation_p.S106F	NM_002959.5	NP_002950.3	Q99523	SORT_HUMAN	sortilin 1	242					endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		AAAATTCTTGGACACCCACAG	0.388000													39	132					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107288690	107288690	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:107288690G>A	ENST00000277216.3	-	1	800	c.801C>T	c.(799-801)ctC>ctT	p.L267L		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						CTTTCCCAAGGAGGTCCTGGG	0.428000													29	95					0	0	1	0	0
SLC28A1	9154	broad.mit.edu	37	15	85448774	85448774	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:85448774C>T	ENST00000394573.1	+	8	810	c.608C>T	c.(607-609)tCc>tTc	p.S203F	SLC28A1_ENST00000537216.1_Missense_Mutation_p.S203F|SLC28A1_ENST00000537703.1_Missense_Mutation_p.S125F|SLC28A1_ENST00000538177.1_Missense_Mutation_p.S203F|SLC28A1_ENST00000537624.1_Missense_Mutation_p.S203F|SLC28A1_ENST00000286749.3_Missense_Mutation_p.S203F	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	203					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGGTAGGTGTCCTGGAGGGCC	0.597000													10	33					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142132991	142132991	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:142132991G>A	ENST00000264951.4	-	14	1696	c.1579C>T	c.(1579-1581)Cct>Tct	p.P527S	XRN1_ENST00000392981.2_Missense_Mutation_p.P527S	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	527					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TAGCATGCAGGAAGTAAATTT	0.358000													20	99					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58601492	58601492	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:58601492G>A	ENST00000240727.6	-	2	542	c.143C>T	c.(142-144)tCc>tTc	p.S48F	ZSCAN18_ENST00000600404.1_Missense_Mutation_p.S104F|ZSCAN18_ENST00000421612.2_Intron|ZSCAN18_ENST00000601144.1_Missense_Mutation_p.S48F	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	48					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		ACGCAGGCGGGAGAACTCCAG	0.682000													6	45					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33143391	33143391	+	Missense_Mutation	SNP	G	G	A	rs150877886	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:33143391G>A	ENST00000341947.2	-	30	2563	c.2336C>T	c.(2335-2337)cCg>cTg	p.P779L	COL11A2_ENST00000395197.1_Missense_Mutation_p.P719L|COL11A2_ENST00000357486.1_Missense_Mutation_p.P758L|COL11A2_ENST00000361917.1_Missense_Mutation_p.P672L|COL11A2_ENST00000374708.4_Missense_Mutation_p.P693L|COL11A2_ENST00000374714.1_Missense_Mutation_p.P753L|COL11A2_ENST00000374712.1_Missense_Mutation_p.P698L|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374713.1_Missense_Mutation_p.P732L	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	779	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GTCTCCAGTCGGTCCAGTGCG	0.647000													11	59					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212683	26212683	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:26212683C>T	ENST00000379034.1	+	2	869	c.720C>T	c.(718-720)acC>acT	p.T240T		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	240	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						TCAACAGAACCTCCCAACATT	0.498000													21	38					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993268	28993268	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:28993268G>A	ENST00000359747.4	+	15	2919	c.2890G>A	c.(2890-2892)Gat>Aat	p.D964N	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.D945N	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	945					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACCTGTCTATGATATTCAAGG	0.433000													49	212					0	0	1	0	0
MAP4K4	9448	broad.mit.edu	37	2	102480495	102480495	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:102480495T>G	ENST00000324219.4	+	17	2153	c.2079T>G	c.(2077-2079)agT>agG	p.S693R	MAP4K4_ENST00000425019.1_Intron|MAP4K4_ENST00000302217.5_Intron|MAP4K4_ENST00000350878.4_Missense_Mutation_p.S588R|MAP4K4_ENST00000456652.1_Intron|MAP4K4_ENST00000347699.4_Intron|MAP4K4_ENST00000413150.2_Intron|MAP4K4_ENST00000350198.4_Intron			O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	617					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GATCAGACAGTGACGAGGTGC	0.448000													14	83					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1617025	1617025	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:1617025C>T	ENST00000381580.1	-	3	637	c.458G>A	c.(457-459)gGg>gAg	p.G153E	SIRPG_ENST00000344103.4_Intron|SIRPG_ENST00000303415.3_Missense_Mutation_p.G186E|RP11-77C3.3_ENST00000456177.1_RNA|SIRPG_ENST00000216927.4_Missense_Mutation_p.G186E|SIRPG_ENST00000381583.2_Missense_Mutation_p.G186E			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	186	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						GAGCTCATTCCCATTTTTGAA	0.577000													15	100					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184106424	184106424	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:184106424G>A	ENST00000204604.1	+	21	2850	c.2604G>A	c.(2602-2604)ggG>ggA	p.G868G	CHRD_ENST00000348986.3_Silent_p.G828G|CHRD_ENST00000450923.1_Silent_p.G868G|CHRD_ENST00000545352.1_Silent_p.G410G|EIF2B5_ENST00000444495.1_Intron	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	868					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGCTGATGGGCCCCGGGGCT	0.617000													19	97					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197143364	197143364	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:197143364G>T	ENST00000260983.2	-	15	3205	c.3023C>A	c.(3022-3024)tCc>tAc	p.S1008Y	HECW2_ENST00000409111.1_Missense_Mutation_p.S652Y	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	1008	Interaction with TP73.|WW 2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						GGTGGTGCGGGAGTTGTGGTC	0.507000													7	38					0.000157383	0.00015913	1	1	0
NWD1	284434	broad.mit.edu	37	19	16860439	16860439	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:16860439A>C	ENST00000524140.2	+	6	1404	c.986A>C	c.(985-987)gAt>gCt	p.D329A	NWD1_ENST00000552788.1_Missense_Mutation_p.D329A|NWD1_ENST00000549814.1_Missense_Mutation_p.D329A|NWD1_ENST00000523826.1_Missense_Mutation_p.D123A|NWD1_ENST00000379808.3_Missense_Mutation_p.D329A|NWD1_ENST00000339803.6_Missense_Mutation_p.D194A	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	329							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTCAGGCACGATGACAGCAAG	0.617000													11	60					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113275983	113275983	+	Silent	SNP	G	G	A	rs61754530		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:113275983G>A	ENST00000297405.5	-	61	9991	c.9747C>T	c.(9745-9747)ttC>ttT	p.F3249F	CSMD3_ENST00000352409.3_Silent_p.F3179F|CSMD3_ENST00000455883.2_Silent_p.F3080F|CSMD3_ENST00000343508.3_Silent_p.F3209F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3249	Sushi 25.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGCCCCAGTCGAAATTTGTTC	0.453000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	82					0	0	1	0	0
SERAC1	84947	broad.mit.edu	37	6	158541537	158541537	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:158541537G>A	ENST00000367102.2	-	11	1227	c.1086C>T	c.(1084-1086)atC>atT	p.I362I	SERAC1_ENST00000367104.3_Silent_p.I362I|SERAC1_ENST00000367101.1_Silent_p.I362I			Q96JX3	SRAC1_HUMAN	serine active site containing 1	362					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds			endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	15		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		GATTTGCCAGGATTCTGGCAG	0.448000													16	92					0	0	1	0	0
OR2T27	403239	broad.mit.edu	37	1	248813482	248813482	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:248813482C>T	ENST00000344889.3	-	1	703	c.704G>A	c.(703-705)gGa>gAa	p.G235E		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CACAGCCTTTCCCCTCCCCTC	0.512000													5	35					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632412	143632412	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:143632412C>T	ENST00000408955.2	+	1	154	c.87C>T	c.(85-87)tcC>tcT	p.S29S		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CCCTGTTTTCCCTGTTCTTGG	0.453000													34	210					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99129800	99129800	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:99129800C>T	ENST00000394170.2	+	7	2699	c.2448C>T	c.(2446-2448)ctC>ctT	p.L816L	ZKSCAN5_ENST00000451158.1_Silent_p.L816L|ZKSCAN5_ENST00000326775.5_Silent_p.L816L	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	816					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GTTGTAGCCTCTTTAAACACC	0.388000													26	147					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101063357	101063357	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:101063357G>A	ENST00000313669.7	+	0	450				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		GCCGGTGGCCGGGGCCCTGCG	0.652000													6	42					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46799755	46799755	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:46799755G>A	ENST00000529230.1	-	22	2728	c.2682C>T	c.(2680-2682)atC>atT	p.I894I	CKAP5_ENST00000312055.5_Silent_p.I894I|CKAP5_ENST00000354558.3_Silent_p.I894I|CKAP5_ENST00000415402.1_Silent_p.I894I			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	894					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						TATTCGGTTGGATAAATTTTG	0.378000													24	123					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94634421	94634421	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:94634421C>T	ENST00000258526.4	+	11	2530	c.2281C>T	c.(2281-2283)Cct>Tct	p.P761S		NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	761					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CCTTATATTTCCTGCTACCAC	0.383000													31	191					0	0	1	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003616	75003616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:75003616C>T	ENST00000373359.2	-	1	1463	c.1271G>A	c.(1270-1272)tGg>tAg	p.W424*		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	424	MAGE 2.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AAGCAAGTTCCAGACATTGGC	0.488000													31	84					0	0	1	0	0
KLF10	7071	broad.mit.edu	37	8	103664119	103664119	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:103664119G>A	ENST00000395884.3	-	3	1310	c.408C>T	c.(406-408)ctC>ctT	p.L136L	KLF10_ENST00000285407.6_Silent_p.L147L	NM_001032282.2	NP_001027453.1	Q13118	KLF10_HUMAN	Kruppel-like factor 10	147					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(3)	18	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			GAGCTTTGGGGAGTTTGGGGG	0.493000											OREG0018913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	108					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475859	120475859	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:120475859G>A	ENST00000355622.6	+	3	1554	c.1453G>A	c.(1453-1455)Gaa>Aaa	p.E485K	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.E445K	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	485					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TTCTTTCCAGGAAAACTTCCT	0.448000													20	75					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91465117	91465117	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:91465117T>G	ENST00000416354.1	+	2	138	c.66T>G	c.(64-66)atT>atG	p.I22M	KIF20B_ENST00000260753.4_Missense_Mutation_p.I22M|KIF20B_ENST00000394289.2_Missense_Mutation_p.I22M|KIF20B_ENST00000371728.3_Missense_Mutation_p.I22M			Q96Q89	KI20B_HUMAN	kinesin family member 20B	22					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						CTGACCCAATTGCAAGGCCTT	0.358000													22	150					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24199186	24199186	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:24199186C>T	ENST00000265769.4	+	16	1856	c.1746C>T	c.(1744-1746)ttC>ttT	p.F582F	RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000397649.3_Silent_p.F329F	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	582	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TAGTGACTTTCCTGACATGTA	0.423000													23	127					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25915531	25915531	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:25915531G>A	ENST00000398988.3	+	7	1050	c.605G>A	c.(604-606)cGg>cAg	p.R202Q	KSR1_ENST00000319524.6_Missense_Mutation_p.R339Q|KSR1_ENST00000509603.2_Missense_Mutation_p.R339Q|KSR1_ENST00000581975.1_3'UTR|KSR1_ENST00000268763.6_Missense_Mutation_p.R202Q	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	337					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CAGATGGTACGGAGGGATATC	0.647000													3	7					0	0	1	0	0
GCK	2645	broad.mit.edu	37	7	44228513	44228513	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:44228513C>T	ENST00000403799.3	-	1	509	c.40G>A	c.(40-42)Gag>Aag	p.E14K	GCK_ENST00000437084.1_Missense_Mutation_p.E14K|GCK_ENST00000476008.1_Intron	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	14					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						GATACCTTCTCCTTCTTGGCG	0.562000													5	31					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31596796	31596796	+	Silent	SNP	G	G	A	rs140651875	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:31596796G>A	ENST00000379416.3	-	16	1677	c.1629C>T	c.(1627-1629)ttC>ttT	p.F543F		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	543					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity	p.F543F(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TTGCACTGGCGAAAGTGGGGT	0.463000													6	23					0	0	1	0	0
RAB3B	5865	broad.mit.edu	37	1	52385653	52385653	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:52385653C>T	ENST00000371655.3	-	5	818	c.606G>A	c.(604-606)aaG>aaA	p.K202K		NM_002867.3	NP_002858.2	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	202					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	9						GACGCGTGTTCTTGGAGGAGC	0.592000													19	43					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118327281	118327281	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:118327281G>A	ENST00000369221.2	+	13	1397	c.1369G>A	c.(1369-1371)Gaa>Aaa	p.E457K		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	457	PLAT.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CGTCAGGGAGGAAGTTCTGCT	0.438000													12	53					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14954330	14954330	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrY:14954330A>T	ENST00000338981.3	+	38	7322	c.6377A>T	c.(6376-6378)cAc>cTc	p.H2126L	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	2126					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TTTATTGCACACTTTTCCTTG	0.388000													26	59					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197398637	197398637	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:197398637C>T	ENST00000367397.1	+	4	1736	c.878C>T	c.(877-879)tCc>tTc	p.S293F	CRB1_ENST00000367399.2_Missense_Mutation_p.S800F|CRB1_ENST00000535699.1_Missense_Mutation_p.S888F|CRB1_ENST00000367400.3_Missense_Mutation_p.S912F|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000544212.1_Missense_Mutation_p.S393F			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	912	EGF-like 7; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TTCTCCTGTTCCTGTCCTGCC	0.542000													37	108					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61585198	61585198	+	Splice_Site	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:61585198G>A	ENST00000238508.3	+	4	293		c.e4-1			NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				CTCTTTTAAAGGAATTCAACT	0.338000													6	32					0	0	1	0	0
RAB37	326624	broad.mit.edu	37	17	72736954	72736954	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:72736954C>T	ENST00000392610.1	+	2	182	c.141C>T	c.(139-141)atC>atT	p.I47I	RAB37_ENST00000392613.5_Silent_p.I47I|RAB37_ENST00000392614.4_Silent_p.I52I|RAB37_ENST00000340415.3_Intron|RAB37_ENST00000402449.4_Intron|RAB37_ENST00000528438.1_Silent_p.I20I|RAB37_ENST00000392615.5_Intron|RAB37_ENST00000392612.3_Intron			Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family	47					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	12						GTTTCCTGATCCAATTCAAAG	0.577000													44	176					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14307065	14307065	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:14307065G>A	ENST00000378053.3	-	2	1344	c.1088C>T	c.(1087-1089)aCc>aTc	p.T363I	MACROD2_ENST00000310348.4_Intron|FLRT3_ENST00000341420.4_Missense_Mutation_p.T363I|MACROD2_ENST00000217246.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	363					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TATCTGAATGGTGCTTACAAT	0.493000													27	170					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117641144	117641144	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:117641144C>T	ENST00000368508.3	-	36	6025	c.5827G>A	c.(5827-5829)Gaa>Aaa	p.E1943K	ROS1_ENST00000368507.3_Missense_Mutation_p.E1937K|GOPC_ENST00000467125.1_5'UTR	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1943					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GTCAGTTTTTCCCGAGGGAAG	0.458000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								16	62					0	0	1	0	0
MRPL15	29088	broad.mit.edu	37	8	55060096	55060096	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:55060096C>T	ENST00000260102.4	+	5	782	c.708C>T	c.(706-708)ctC>ctT	p.L236L		NM_014175.3	NP_054894.1	Q9P015	RM15_HUMAN	mitochondrial ribosomal protein L15	236					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)|skin(3)	10		Lung NSC(129;0.109)|all_epithelial(80;0.134)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;4.3e-07)|Epithelial(17;5.79e-05)|all cancers(17;0.000458)			GACTTGAACTCGCCAGGAAGT	0.438000													13	79					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129380963	129380963	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:129380963G>A	ENST00000421865.2	+	3	367	c.318G>A	c.(316-318)aaG>aaA	p.K106K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	106	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTGATGGAAAGAACACTTGGT	0.358000													20	60					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166503	19166503	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:19166503G>A	ENST00000375371.3	-	6	2131	c.2110C>T	c.(2110-2112)Ccc>Tcc	p.P704S		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	704					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CGGGTGGTGGGACTGAGGCCC	0.557000													14	94					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35149097	35149097	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:35149097G>A	ENST00000156471.5	-	35	4579	c.4354C>T	c.(4354-4356)Cct>Tct	p.P1452S		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	1452						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		GATAAAGCAGGGATGGCTTCT	0.557000													18	83					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128477426	128477426	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:128477426G>A	ENST00000322313.4	-	16	2331	c.2173C>T	c.(2173-2175)Cct>Tct	p.P725S		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	725	Collagen-like.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TGACCCTGAGGGCCAGGCGGG	0.632000													24	87					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	G	A	rs121913387		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:21971186G>A	ENST00000304494.5	-	2	442	c.172C>T	c.(172-174)Cga>Tga	p.R58*	CDKN2A_ENST00000479692.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000446177.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000498124.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000497750.1_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000578845.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000494262.1_Nonsense_Mutation_p.R7*|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000579755.1_Missense_Mutation_p.P72L|CDKN2A_ENST00000530628.2_Missense_Mutation_p.P72L|CDKN2A_ENST00000579122.1_Nonsense_Mutation_p.R58*|CDKN2A_ENST00000498628.2_Nonsense_Mutation_p.R7*|CDKN2A_ENST00000361570.3_Missense_Mutation_p.P113L	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	58			R -> Q (in dbSNP:rs36204273).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.R58*(78)|p.?(45)|p.M53_R58del(3)|p.P113L(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*88(2)|p.0(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.P113fs*>61(1)|p.R58fs*62(1)|p.R58fs*61(1)|p.G55fs*86(1)|p.R58R(1)|p.A57fs*85(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			3	9					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51499382	51499382	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:51499382G>A	ENST00000600767.1	-	7	1205	c.716C>T	c.(715-717)cCt>cTt	p.P239L	KLK8_ENST00000598195.1_5'UTR|KLK8_ENST00000391806.2_Missense_Mutation_p.P284L|KLK8_ENST00000291726.7_Missense_Mutation_p.P239L|KLK8_ENST00000320838.5_3'UTR|KLK8_ENST00000593490.1_3'UTR|KLK8_ENST00000347619.4_Missense_Mutation_p.P98L|CTB-147C22.9_ENST00000594512.1_RNA			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	239	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		ATAGACGCCAGGTTTGTCGGA	0.547000													31	121					0	0	1	0	0
TRAV26-1	28657	broad.mit.edu	37	14	22592169	22592169	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:22592169G>A	ENST00000390455.3	+	0	463																											ACAGAAGACAGAAAGTCCAGC	0.498000													7	33					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20658822	20658822	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:20658822C>T	ENST00000525748.1	+	12	2115	c.1842C>T	c.(1840-1842)ttC>ttT	p.F614F	SLC6A5_ENST00000528440.1_3'UTR	NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	614					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	TTTGTTTCTTCATCATGGGTT	0.527000													14	84					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31323206	31323206	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:31323206G>A	ENST00000265071.2	+	12	2429	c.2164G>A	c.(2164-2166)Gaa>Aaa	p.E722K		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	722					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.E722K(2)		NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AAGGTTAAAGGAAAATGACAC	0.562000													10	49					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56676729	56676729	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:56676729G>A	ENST00000389934.3	-	14	2094	c.1977C>T	c.(1975-1977)tcC>tcT	p.S659S	TEX14_ENST00000349033.5_Silent_p.S659S|TEX14_ENST00000240361.8_Silent_p.S665S	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	665						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTTCTTCCATGGATTTCAGTT	0.468000													22	141					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127789729	127789729	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:127789729C>T	ENST00000368679.4	-	9	1141	c.832G>A	c.(832-834)Gac>Aac	p.D278N	ADAM12_ENST00000368676.4_Missense_Mutation_p.D278N	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	278	Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GTGAATGGGTCCTGACTTACA	0.483000													8	49					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55039417	55039417	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:55039417C>T	ENST00000370862.3	+	1	368	c.32C>T	c.(31-33)cCt>cTt	p.P11L		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	11			P -> T (in dbSNP:rs41271312).		feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GACTCCCCCCCTTGTCGCAAC	0.567000													26	101					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768045	77768045	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:77768045G>A	ENST00000521891.2	+	10	9336	c.8888G>A	c.(8887-8889)gGg>gAg	p.G2963E	ZFHX4_ENST00000518282.1_Missense_Mutation_p.G2937E|ZFHX4_ENST00000455469.2_Missense_Mutation_p.G2918E|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G2918E	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2918						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAAATGTTAGGGAATGAGATT	0.423000										HNSCC(33;0.089)			6	33					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19185996	19185996	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:19185996G>A	ENST00000375371.3	-	1	180	c.159C>T	c.(157-159)ttC>ttT	p.F53F	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	53					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GCACCTGCAGGAAGTTAAGGT	0.607000													19	95					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13933738	13933738	+	Silent	SNP	C	C	G	rs146966218	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:13933738C>G	ENST00000294489.6	+	2	707	c.366C>G	c.(364-366)gcC>gcG	p.A122A	PDPN_ENST00000376057.4_Silent_p.A122A|PDPN_ENST00000509009.1_Silent_p.A41A|PDPN_ENST00000475043.1_Silent_p.A4A|PDPN_ENST00000487038.1_Silent_p.A4A|PDPN_ENST00000513143.1_Silent_p.A4A|PDPN_ENST00000376061.4_Silent_p.A4A			Q86YL7	PDPN_HUMAN	podoplanin	46					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		TGCCAGGTGCCGAAGATGATG	0.517000													6	63					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33154568	33154568	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:33154568G>A	ENST00000341947.2	-	5	861	c.634C>T	c.(634-636)Cca>Tca	p.P212S	COL11A2_ENST00000395197.1_Missense_Mutation_p.P212S|COL11A2_ENST00000395194.1_Missense_Mutation_p.P212S|COL11A2_ENST00000357486.1_Missense_Mutation_p.P212S|COL11A2_ENST00000361917.1_Missense_Mutation_p.P212S|COL11A2_ENST00000374708.4_Missense_Mutation_p.P212S|COL11A2_ENST00000374714.1_Missense_Mutation_p.P212S|COL11A2_ENST00000374712.1_Missense_Mutation_p.P212S|COL11A2_ENST00000374713.1_Missense_Mutation_p.P212S	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	212	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TGGACCCCTGGGACAATGGCC	0.557000													22	117					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109954514	109954514	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:109954514G>A	ENST00000424296.2	-	11	1022	c.946C>T	c.(946-948)Cgt>Tgt	p.R316C	AK9_ENST00000341338.6_5'UTR|AK9_ENST00000285397.5_Missense_Mutation_p.R316C|AK9_ENST00000368948.2_Missense_Mutation_p.R316C	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		GCAAGAGTACGAAATAGCTCA	0.303000													7	34					0	0	1	0	0
ATRIP	84126	broad.mit.edu	37	3	48506019	48506019	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:48506019C>T	ENST00000412052.1	+	11	2196	c.1734C>T	c.(1732-1734)ccC>ccT	p.P578P	ATRIP_ENST00000346691.4_Intron|ATRIP_ENST00000357105.6_Silent_p.P544P|ATRIP_ENST00000320211.3_Silent_p.P671P	NM_001271023.1	NP_001257952.1	Q8WXE1	ATRIP_HUMAN	ATR interacting protein	671					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)	22				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGCAGAGCCCCTTGCCCCCAG	0.602000								Other conserved DNA damage response genes					17	99					0	0	1	0	0
BPIFC	254240	broad.mit.edu	37	22	32811929	32811929	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:32811929G>A	ENST00000397452.1	-	15	1484	c.1374C>T	c.(1372-1374)ttC>ttT	p.F458F	BPIFC_ENST00000534972.1_Silent_p.F182F|BPIFC_ENST00000300399.3_Silent_p.F458F|BPIFC_ENST00000432451.2_Silent_p.F215F			Q8NFQ6	BPIL2_HUMAN	BPI fold containing family C	458						extracellular region	lipopolysaccharide binding|phospholipid binding										CTGAATTGACGAATAAGAATT	0.368000													6	28					0	0	1	0	0
SUGP2	10147	broad.mit.edu	37	19	19135467	19135467	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:19135467G>A	ENST00000601879.1	-	3	1987	c.1690C>T	c.(1690-1692)Cct>Tct	p.P564S	SUGP2_ENST00000456085.2_Missense_Mutation_p.P333S|SUGP2_ENST00000452918.2_Missense_Mutation_p.P564S|SUGP2_ENST00000337018.6_Missense_Mutation_p.P564S|SUGP2_ENST00000600377.1_Missense_Mutation_p.P578S			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	564					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						TGAATTTCAGGTTTCGTAGGA	0.468000													11	68					0	0	1	0	0
USP5	8078	broad.mit.edu	37	12	6972535	6972535	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:6972535C>T	ENST00000229268.8	+	15	2000	c.1948C>T	c.(1948-1950)Ccg>Tcg	p.P650S	USP5_ENST00000541969.1_3'UTR|USP5_ENST00000389231.5_Intron	NM_001098536.1	NP_001092006.1	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 (isopeptidase T)	650					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(6)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|skin(2)|urinary_tract(2)	36						CTTCTCCTCTCCGACATGTTA	0.567000													11	101					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74005475	74005475	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:74005475C>G	ENST00000301607.3	-	22	4064	c.3811G>C	c.(3811-3813)Gac>Cac	p.D1271H	EVPL_ENST00000586740.1_Missense_Mutation_p.D1293H	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1271	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						TTCAGGCGGTCGATCTCACGC	0.672000													11	118					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20673127	20673127	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:20673127C>T	ENST00000307493.4	-	6	1048	c.981G>A	c.(979-981)caG>caA	p.Q327Q	ACSM1_ENST00000520010.1_Silent_p.Q327Q|ACSM1_ENST00000219151.4_5'UTR	NM_052956.2	NP_443188.2	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	327					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TGGTGAAATCCTGCTGCAGAA	0.368000													14	59					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41165918	41165918	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:41165918C>T	ENST00000483722.1	-	2	490	c.305G>A	c.(304-306)cGa>cAa	p.R102Q		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	102	Ig-like V-type.				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCACCAGTATCGGCCTGAGTC	0.617000													7	66					0	0	1	0	0
SUCLG2	8801	broad.mit.edu	37	3	67579591	67579591	+	Silent	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:67579591T>C	ENST00000307227.5	-	3	273	c.246A>G	c.(244-246)ttA>ttG	p.L82L	SUCLG2_ENST00000493112.1_Silent_p.L82L|SUCLG2_ENST00000492795.1_Silent_p.L82L	NM_003848.3	NP_003839.2	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming, beta subunit	82	ATP-grasp.				succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	10		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	TCTGGGCTTTTAAAACAATTT	0.333000													24	81					0	0	1	0	0
CEACAM6	4680	broad.mit.edu	37	19	42260805	42260805	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:42260805C>T	ENST00000199764.6	+	2	580	c.362C>T	c.(361-363)aCc>aTc	p.T121I	CEA_ENST00000598976.1_Intron	NM_002483.4	NP_002474.3	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	121	Ig-like V-type.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				breast(1)|kidney(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		GGATTCTATACCCTACAAGTC	0.493000													79	415					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184787805	184787805	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:184787805G>A	ENST00000367511.3	-	9	1333	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	380					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						TGGTGGTCTGGAAGTTCTGGC	0.507000													17	182					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49925742	49925742	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49925742C>T	ENST00000270631.1	-	2	387	c.286G>A	c.(286-288)Gtg>Atg	p.V96M		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	96					neuropeptide signaling pathway	extracellular region				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GCATCCAACACCAGCAGCTTG	0.687000													6	38					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110450332	110450332	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:110450332G>A	ENST00000260283.4	-	16	3622	c.3338C>T	c.(3337-3339)tCt>tTt	p.S1113F	ARHGAP20_ENST00000528829.1_Missense_Mutation_p.S1077F|ARHGAP20_ENST00000524756.1_Missense_Mutation_p.S1090F|ARHGAP20_ENST00000529591.1_Missense_Mutation_p.S656F|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.S1087F|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.S1087F|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.S1077F	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1113					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		CTGGAAGGGAGAAGAACTACA	0.512000													12	65					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316581	30316581	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:30316581G>A	ENST00000375377.1	-	3	2597	c.2496C>T	c.(2494-2496)atC>atT	p.I832I		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	832										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CTAACTGACTGATCAAATCCC	0.557000													24	124					0	0	1	0	0
C2orf66	401027	broad.mit.edu	37	2	197672278	197672278	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:197672278G>A	ENST00000342506.2	-	2	1131	c.243C>T	c.(241-243)ttC>ttT	p.F81F		NM_213608.2	NP_998773.1	Q6UXQ4	CB066_HUMAN	chromosome 2 open reading frame 66	81						extracellular region		p.F81F(1)		endometrium(2)|large_intestine(2)|lung(4)|ovary(1)	9						CATTCGTGGGGAAAGGATTTG	0.398000													32	129					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47498936	47498936	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:47498936G>A	ENST00000371901.3	+	4	638	c.388G>A	c.(388-390)Gga>Aga	p.G130R	CYP4X1_ENST00000538609.1_Missense_Mutation_p.G129R	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	130						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						GGCTCTAGACGGACCCAAGTG	0.433000													25	54					0	0	1	0	0
FGF17	8822	broad.mit.edu	37	8	21905578	21905578	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:21905578G>A	ENST00000359441.3	+	5	972	c.469G>A	c.(469-471)Ggg>Agg	p.G157R	FGF17_ENST00000521709.1_3'UTR|FGF17_ENST00000518533.1_Missense_Mutation_p.G146R	NM_003867.2	NP_003858.1	O60258	FGF17_HUMAN	fibroblast growth factor 17	157					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|nervous system development	extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	8				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		CACGCGGCAGGGGCGGCCCCG	0.657000													6	21					0	0	1	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839601	100839601	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:100839601G>A	ENST00000223114.4	-	6	904	c.738C>T	c.(736-738)ggC>ggT	p.G246G	MOGAT3_ENST00000440203.2_Silent_p.G246G|MOGAT3_ENST00000379423.3_Intron	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	246					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					GCTGCCAGGAGCCTGTGGCAA	0.582000													4	33					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166915616	166915616	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:166915616G>A	ENST00000061240.2	+	4	1092	c.445G>A	c.(445-447)Gct>Act	p.A149T	TLL1_ENST00000507499.1_Missense_Mutation_p.A149T|TLL1_ENST00000513213.1_Missense_Mutation_p.A149T	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	149	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.A149T(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TCCCAGAGCCGCTACATCAAG	0.418000													5	54					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482293	140482293	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140482293C>T	ENST00000231130.2	+	1	2060	c.2060C>T	c.(2059-2061)aCc>aTc	p.T687I		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		687					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACTTGCTCACCGTCTACCTG	0.687000													26	98					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196967294	196967294	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:196967294T>G	ENST00000367414.5	+	7	1135	c.1079T>G	c.(1078-1080)gTt>gGt	p.V360G	CFHR5_ENST00000256785.4_Missense_Mutation_p.V336G	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	336	Sushi 6.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						ATAGCAGGAGTTAATATAAAA	0.284000													6	17					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144906302	144906302	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:144906302T>A	ENST00000370490.1	+	1	6614	c.2359T>A	c.(2359-2361)Tcc>Acc	p.S787T	SLITRK2_ENST00000428560.2_Missense_Mutation_p.S787T|SLITRK2_ENST00000413937.2_Missense_Mutation_p.S787T|SLITRK2_ENST00000447897.2_Missense_Mutation_p.S787T|SLITRK2_ENST00000434188.2_Missense_Mutation_p.S787T			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	787						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					GTTTGCCCCTTCCTATGAATC	0.458000													32	77					0	0	1	0	0
NR0B2	8431	broad.mit.edu	37	1	27238545	27238545	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:27238545C>T	ENST00000254227.3	-	2	590	c.565G>A	c.(565-567)Ggg>Agg	p.G189R		NM_021969.2	NP_068804.1	Q15466	NR0B2_HUMAN	nuclear receptor subfamily 0, group B, member 2	189	Ligand-binding (By similarity).		G -> E (in early-onset obesity; Japanese population; strong decrease of repressor activity).		cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity			NS(1)|large_intestine(1)|lung(3)	5		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		TGCAGGTGCCCAATGTGGGAG	0.652000													9	41					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136589404	136589404	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:136589404C>T	ENST00000531224.1	-	10	2545	c.2293G>A	c.(2293-2295)Gaa>Aaa	p.E765K	BCLAF1_ENST00000527536.1_Missense_Mutation_p.E765K|BCLAF1_ENST00000392348.2_Missense_Mutation_p.E763K|BCLAF1_ENST00000527759.1_Missense_Mutation_p.E763K|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000031135.9_5'UTR|BCLAF1_ENST00000530767.1_Missense_Mutation_p.E592K|BCLAF1_ENST00000353331.4_Missense_Mutation_p.E763K	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	765					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding	p.E765K(1)		haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCCTTTTCTTCTCGAGAACTG	0.383000													10	163					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18691918	18691918	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:18691918C>T	ENST00000251296.1	+	6	1125	c.742C>T	c.(742-744)Cgt>Tgt	p.R248C		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	248						extracellular region		p.R248G(1)		endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		GCGCCCCTCCCGTGGCCTGAC	0.637000													24	129					0	0	1	0	0
C19orf45	374877	broad.mit.edu	37	19	7569240	7569240	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:7569240G>A	ENST00000361664.2	+	4	866	c.725G>A	c.(724-726)gGa>gAa	p.G242E		NM_198534.2	NP_940936.2	Q8NA69	CS045_HUMAN	chromosome 19 open reading frame 45	242										endometrium(1)|kidney(1)|liver(1)|lung(2)|ovary(2)|stomach(1)	8						ATCAGCTATGGATCAACGTGT	0.597000													9	59					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121758671	121758671	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:121758671C>T	ENST00000261367.7	+	6	1808	c.380C>T	c.(379-381)tCg>tTg	p.S127L	SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000261368.8_Missense_Mutation_p.S80L|SNCAIP_ENST00000503116.2_Missense_Mutation_p.S127L|SNCAIP_ENST00000379533.2_Missense_Mutation_p.S127L|SNCAIP_ENST00000379536.2_Missense_Mutation_p.S80L|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000542191.1_Intron			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	80					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AAGCGGGTTTCGCCACTGAAA	0.478000													11	36					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103901748	103901748	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:103901748C>T	ENST00000278070.2	+	5	3522	c.3483C>T	c.(3481-3483)ttC>ttT	p.F1161F	PPRC1_ENST00000413464.2_Silent_p.F1161F|PPRC1_ENST00000489648.1_3'UTR|PPRC1_ENST00000370012.1_Silent_p.F128F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		TACAGGCTTTCATCAGTGAGA	0.557000													13	53					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72170667	72170667	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:72170667C>A	ENST00000537465.1	-	8	1128	c.970G>T	c.(970-972)Gag>Tag	p.E324*	PMFBP1_ENST00000237353.10_Nonsense_Mutation_p.E324*|PMFBP1_ENST00000355636.6_Nonsense_Mutation_p.E179*			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	324										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TTCTGGTACTCCTCCACATGC	0.542000													4	32					0.00909568	0.00913327	1	1	0
MAGEA6	4105	broad.mit.edu	37	X	151869752	151869752	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:151869752C>T	ENST00000329342.5	+	3	667	c.442C>T	c.(442-444)Cct>Tct	p.P148S		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	148	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GTACTTCTTTCCTGTGATCTT	0.522000													37	89					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43250705	43250705	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:43250705G>A	ENST00000259750.4	+	14	2310	c.2227G>A	c.(2227-2229)Gaa>Aaa	p.E743K		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	743	Glu-rich.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			ggaagatgaggaagaggaaga	0.577000													4	17					0	0	1	0	0
SPANXN5	494197	broad.mit.edu	37	X	52825665	52825665	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:52825665C>T	ENST00000375511.3	-	2	834	c.82G>A	c.(82-84)Gag>Aag	p.E28K		NM_001009616.2	NP_001009616.1	Q5MJ07	SPXN5_HUMAN	SPANX family, member N5	28										large_intestine(1)|lung(5)|skin(2)	8	Ovarian(276;0.236)					TTTGGTGTCTCCTGCATCTGT	0.413000													14	43					0	0	1	0	0
EIF2AK2	5610	broad.mit.edu	37	2	37353503	37353503	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:37353503G>A	ENST00000233057.4	-	11	1159	c.837C>T	c.(835-837)ggC>ggT	p.G279G	EIF2AK2_ENST00000405334.1_Intron|EIF2AK2_ENST00000395127.2_Silent_p.G279G	NM_001135651.2	NP_001129123.1	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 2	279	Protein kinase.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)	22		all_hematologic(82;0.248)				TGAAAACTTGGCCAAATCCAC	0.313000													15	87					0	0	1	0	0
RPUSD4	84881	broad.mit.edu	37	11	126073501	126073501	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:126073501G>A	ENST00000298317.4	-	7	999	c.946C>T	c.(946-948)Cgc>Tgc	p.R316C	RPUSD4_ENST00000533628.1_Missense_Mutation_p.R285C	NM_032795.2	NP_116184.2	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	316					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		GGGATGTAGCGGGCCTTCGAC	0.582000													15	36					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121724107	121724107	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:121724107C>T	ENST00000273691.3	-	3	468	c.363G>A	c.(361-363)aaG>aaA	p.K121K	ILDR1_ENST00000393631.1_Silent_p.K121K|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000462014.1_Silent_p.K133K|ILDR1_ENST00000344209.5_Silent_p.K121K	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	121	Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GGATGGTGATCTTGCGCTGCC	0.632000													4	25					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220161167	220161167	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:220161167G>A	ENST00000295718.2	-	17	2622	c.2382C>T	c.(2380-2382)ttC>ttT	p.F794F	PTPRN_ENST00000497977.1_5'UTR|PTPRN_ENST00000423636.2_Silent_p.F704F|PTPRN_ENST00000409251.3_Silent_p.F765F	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	794	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CCACCTGCCAGAAGTCTGCGA	0.602000													7	69					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1729758	1729758	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:1729758C>T	ENST00000313288.4	+	4	735	c.629C>T	c.(628-630)tCc>tTc	p.S210F		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	210						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AGGACAGAGTCCCAGCACAAA	0.592000													5	32					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886824	123886824	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:123886824G>A	ENST00000320891.4	+	1	543	c.543G>A	c.(541-543)ccG>ccA	p.P181P		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	181			P -> S (in dbSNP:rs1893764).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P181P(2)		NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTGACGCACCGCCCATCCTGA	0.542000													41	168					0	0	1	0	0
FMNL2	114793	broad.mit.edu	37	2	153486393	153486393	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:153486393G>A	ENST00000288670.9	+	20	2891	c.2524G>A	c.(2524-2526)Gga>Aga	p.G842R	FMNL2_ENST00000475377.2_Missense_Mutation_p.G217R	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	842	FH2.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						AGCAGTTTATGGATTTAAACT	0.418000													5	24					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67215859	67215859	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:67215859A>C	ENST00000269081.4	-	7	1266	c.357T>G	c.(355-357)aaT>aaG	p.N119K	ABCA10_ENST00000416101.2_Missense_Mutation_p.N119K|ABCA10_ENST00000423818.2_Missense_Mutation_p.Y85D|ABCA10_ENST00000432313.2_Missense_Mutation_p.N119K	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	119					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					GTATCTTCATATTTATTCCAA	0.294000													19	70					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	83938545	83938545	+	Splice_Site	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:83938545C>T	ENST00000369705.3	-	10	1248	c.1132_splice	c.e10+1	p.G378_splice	ME1_ENST00000543031.1_Splice_Site_p.G303_splice|ME1_ENST00000541327.1_Splice_Site_p.G212_splice	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	378					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	AAATGCTTACCTATGAGGGCA	0.368000													22	127					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69683824	69683824	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:69683824C>T	ENST00000265403.7	+	2	823	c.796C>T	c.(796-798)Cct>Tct	p.P266S	UGT2B10_ENST00000458688.2_Missense_Mutation_p.P182S	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	266					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TTTTAAATTTCCTCATCCATT	0.383000													36	217					0	0	1	0	0
NKAIN2	154215	broad.mit.edu	37	6	124979345	124979345	+	Missense_Mutation	SNP	T	T	C	rs138663713		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:124979345T>C	ENST00000368417.1	+	4	347	c.287T>C	c.(286-288)aTc>aCc	p.I96T	NKAIN2_ENST00000546092.1_Intron|NKAIN2_ENST00000545433.1_Missense_Mutation_p.I81T|NKAIN2_ENST00000368416.1_Missense_Mutation_p.I96T	NM_001040214.1	NP_001035304.1	Q5VXU1	NKAI2_HUMAN	Na+/K+ transporting ATPase interacting 2	96						integral to membrane|plasma membrane				cervix(1)|endometrium(1)|large_intestine(3)|lung(12)|skin(2)	19				GBM - Glioblastoma multiforme(226;0.104)		ACAGACCTTATCCTGACTTTT	0.443000													15	54					0	0	1	0	0
VIM	7431	broad.mit.edu	37	10	17271961	17271961	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:17271961G>A	ENST00000544301.1	+	2	953	c.540G>A	c.(538-540)gaG>gaA	p.E180E	VIM_ENST00000224237.5_Silent_p.E180E|VIM_ENST00000485947.1_3'UTR|VIM-AS1_ENST00000605833.1_RNA	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	180	Coil 1B.|Rod.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						ACCTGGCCGAGGACATCATGC	0.697000													6	14					0	0	1	0	0
OR6C70	390327	broad.mit.edu	37	12	55863430	55863430	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:55863430C>T	ENST00000327335.4	-	1	492	c.493G>A	c.(493-495)Gat>Aat	p.D165N	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA	NM_001005499.1	NP_001005499.1	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C, member 70	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D165N(1)		autonomic_ganglia(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	18						GCACAGAAATCCAAGTTAAGA	0.368000													11	87					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23113987	23113987	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:23113987C>T	ENST00000397677.1	+	5	1320	c.672C>T	c.(670-672)gcC>gcT	p.A224A	CHMP7_ENST00000313219.7_Silent_p.A224A	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	224					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TGAAGTTTGCCCGAGGGCCAC	0.532000													36	151					0	0	1	0	0
RRP9	9136	broad.mit.edu	37	3	51971282	51971282	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:51971282G>A	ENST00000232888.6	-	6	516	c.443C>T	c.(442-444)tCt>tTt	p.S148F		NM_004704.3	NP_004695.1	O43818	U3IP2_HUMAN	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	148					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|skin(1)	21				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		ACATGTGATAGAGAGCTGGTG	0.577000													17	70					0	0	1	0	0
SYN1	6853	broad.mit.edu	37	X	47434646	47434646	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:47434646C>T	ENST00000295987.7	-	10	1310	c.1186G>A	c.(1186-1188)Ggt>Agt	p.G396S	SYN1_ENST00000340666.4_Missense_Mutation_p.G396S	NM_006950.3	NP_008881.2	P17600	SYN1_HUMAN	synapsin I	396	C; actin-binding and synaptic-vesicle binding.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(6)|lung(6)|ovary(1)	21						TGGTGGTCACCAATGAGCGGC	0.622000													8	10					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75228542	75228542	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:75228542A>C	ENST00000336926.6	-	2	170	c.144T>G	c.(142-144)atT>atG	p.I48M	HIP1_ENST00000434438.2_Missense_Mutation_p.I48M	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	48	ENTH.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CCTGCGTATTAATGGCCTTAT	0.498000			T	PDGFRB	CMML								18	101					0	0	1	0	0
FUT10	84750	broad.mit.edu	37	8	33247056	33247056	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:33247056G>A	ENST00000327671.5	-	4	1268	c.637C>T	c.(637-639)Ccg>Tcg	p.P213S	FUT10_ENST00000335589.3_Missense_Mutation_p.P151S|FUT10_ENST00000518672.1_Missense_Mutation_p.P185S|FUT10_ENST00000518076.1_5'UTR|FUT10_ENST00000524021.1_Missense_Mutation_p.P185S	NM_032664.3	NP_116053.3	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10 (alpha (1,3) fucosyltransferase)	213					embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	29				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		TACACCAGCGGAGCAAGTCTT	0.473000													24	124					0	0	1	0	0
ZNF578	147660	broad.mit.edu	37	19	53007995	53007995	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:53007995G>A	ENST00000421239.2	+	5	395	c.151G>A	c.(151-153)Gaa>Aaa	p.E51K		NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TTTGTACAGGGAAGTGATGTT	0.498000													30	179					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177226328	177226328	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:177226328C>T	ENST00000361539.4	+	4	789	c.477C>T	c.(475-477)acC>acT	p.T159T	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		159						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AGTCCCTGACCATTTTTGTGG	0.502000													8	56					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043436	20043436	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:20043436G>A	ENST00000570682.1	-	2	983	c.683C>T	c.(682-684)gCc>gTc	p.A228V		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	228						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						GAACAAGATGGCGGTGGTCTT	0.527000													7	78					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104084292	104084292	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:104084292C>T	ENST00000388887.2	+	30	3477	c.3273C>T	c.(3271-3273)ttC>ttT	p.F1091F		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1091	FAS1 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGGGCAACTTCCTTCACTTGG	0.403000													7	55					0	0	1	0	0
GPA33	10223	broad.mit.edu	37	1	167042665	167042665	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:167042665C>T	ENST00000367868.3	-	2	498	c.155G>A	c.(154-156)cGa>cAa	p.R52Q	GPA33_ENST00000527955.1_5'UTR	NM_005814.1	NP_005805.1	Q99795	GPA33_HUMAN	glycoprotein A33 (transmembrane)	52	Ig-like V-type.					integral to plasma membrane	receptor activity			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						AAGTCCCTCTCGACTGGAGGT	0.522000													10	72					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38101301	38101301	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38101301G>A	ENST00000308059.6	+	3	652	c.631G>A	c.(631-633)Gat>Aat	p.D211N	DLEC1_ENST00000452631.2_Missense_Mutation_p.D211N|DLEC1_ENST00000346219.3_Missense_Mutation_p.D211N			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	211					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CTCCCCAGAAGATTACTACAC	0.478000													27	185					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96522539	96522539	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:96522539G>A	ENST00000371321.3	+	1	159	c.77G>A	c.(76-78)aGa>aAa	p.R26K	CYP2C19_ENST00000464755.1_Intron	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	26					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	AGCTCTGGGAGAGGAAAACTC	0.443000													32	132					0	0	1	0	0
C6orf58	352999	broad.mit.edu	37	6	127912721	127912721	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:127912721G>A	ENST00000329722.7	+	6	959	c.947G>A	c.(946-948)aGa>aAa	p.R316K		NM_001010905.1	NP_001010905.1	Q6P5S2	CF058_HUMAN	chromosome 6 open reading frame 58	316						extracellular region				kidney(3)|large_intestine(3)|liver(1)|lung(7)|pancreas(1)	15				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		AATGTATATAGAGATCATTCG	0.269000													5	15					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47308679	47308679	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:47308679G>A	ENST00000335044.2	-	6	1023	c.666C>T	c.(664-666)atC>atT	p.I222I	KIF9_ENST00000444589.2_Silent_p.I222I|KIF9_ENST00000265529.3_Silent_p.I222I|KIF9_ENST00000487440.1_5'UTR|KIF9_ENST00000452770.2_Silent_p.I222I|KIF9_ENST00000352910.4_Silent_p.I129I	NM_001134878.1|NM_182902.3	NP_001128350.1|NP_878905.2	Q9HAQ2	KIF9_HUMAN	kinesin family member 9	222	Kinesin-motor.				blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CCTCTAAGTAGATGGTGAAAA	0.493000													50	294					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56330265	56330265	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:56330265C>T	ENST00000288221.6	-	3	1111	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	286						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		AGCTCCATTTCCTCTAATGTC	0.473000													52	271					0	0	1	0	0
POTEA	340441	broad.mit.edu	37	8	43211924	43211924	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:43211924C>T	ENST00000522175.2	+	0	1247							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TATCAAAAATCCAGGATGCAG	0.363000													16	81					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40642348	40642348	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:40642348G>A	ENST00000342449.3	-	14	1334	c.1256C>T	c.(1255-1257)tCc>tTc	p.S419F	BRWD1_ENST00000333229.2_Missense_Mutation_p.S419F|BRWD1_ENST00000380800.3_Missense_Mutation_p.S419F	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTCCTCTTCGGAAGATAAGTC	0.323000													3	11					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8235333	8235333	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:8235333G>A	ENST00000520004.1	-	3	850	c.586C>T	c.(586-588)Cct>Tct	p.P196S	SGK223_ENST00000330777.4_Missense_Mutation_p.P196S			Q86YV5	SG223_HUMAN		196							ATP binding|non-membrane spanning protein tyrosine kinase activity										TCTTGGTAAGGAAATGAGGGT	0.627000													13	83					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6166762	6166762	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:6166762G>A	ENST00000262450.3	-	39	5755	c.5656C>T	c.(5656-5658)Ccc>Tcc	p.P1886S	CHD5_ENST00000378021.1_Missense_Mutation_p.P743S	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1886					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCCACCGGGGGGATGCGGGAC	0.697000													6	19					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17447126	17447126	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:17447126G>A	ENST00000400588.1	-	6	1259	c.1152C>T	c.(1150-1152)atC>atT	p.I384I		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	384										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AGCCCACAGGGATGCAGACAC	0.587000													11	56					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15281227	15281227	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:15281227G>A	ENST00000263388.2	-	27	5104	c.5029C>T	c.(5029-5031)Cct>Tct	p.P1677S		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1677					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			AAGCCCTCAGGGAACCAGAGG	0.662000													6	42					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106567	55106567	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:55106567G>A	ENST00000453777.1	+	5	531	c.361G>A	c.(361-363)Gcc>Acc	p.A121T	LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000251372.3_Missense_Mutation_p.A121T	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	121	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		TCTCCTAGGAGCCTACATCAA	0.577000													13	122					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26696415	26696415	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:26696415C>T	ENST00000272371.2	-	28	3555	c.3429G>A	c.(3427-3429)cgG>cgA	p.R1143R	OTOF_ENST00000338581.6_Silent_p.R396R|OTOF_ENST00000403946.3_Silent_p.R1143R|OTOF_ENST00000402415.3_Silent_p.R453R|OTOF_ENST00000339598.3_Silent_p.R396R	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1143					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTTTAGGTCCCGTAGGCCCC	0.617000													11	44					0	0	1	0	0
EPS15L1	58513	broad.mit.edu	37	19	16528446	16528446	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:16528446G>A	ENST00000602009.1	-	6	1543	c.648C>T	c.(646-648)gaC>gaT	p.D216D	EPS15L1_ENST00000455140.2_Silent_p.D370D|EPS15L1_ENST00000248070.6_Silent_p.D370D|EPS15L1_ENST00000594975.1_Silent_p.D370D|EPS15L1_ENST00000535753.2_Silent_p.D370D|EPS15L1_ENST00000597937.1_Silent_p.D370D			Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	370					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						AGCCTGAACTGTCCTAGAATT	0.507000											OREG0025334	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	44					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170239053	170239053	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:170239053G>A	ENST00000518525.1	+	11	1578	c.1114G>A	c.(1114-1116)Gaa>Aaa	p.E372K	GABRP_ENST00000519385.1_3'UTR|GABRP_ENST00000265294.4_Missense_Mutation_p.E372K			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	372						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGCCAGCATTGAAATTTCCAG	0.413000													20	115					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77756558	77756558	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:77756558G>A	ENST00000354212.4	-	19	3632	c.3379C>T	c.(3379-3381)Ccc>Tcc	p.P1127S	MAGI2_ENST00000419488.1_Missense_Mutation_p.P1113S|MAGI2_ENST00000522391.1_Missense_Mutation_p.P1127S	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1127						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTGGTGTCGGGGGAGTGCTGC	0.637000													15	124					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25266999	25266999	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:25266999T>C	ENST00000218548.6	+	10	1693	c.1360T>C	c.(1360-1362)Ttc>Ctc	p.F454L	ATP12A_ENST00000381946.3_Missense_Mutation_p.F448L	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	448					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding	p.F448L(1)		breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CCGAGCAGAGTTCAAGCCAGG	0.458000													31	197					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75301974	75301974	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:75301974T>C	ENST00000325680.7	+	20	6425	c.6301T>C	c.(6301-6303)Tgg>Cgg	p.W2101R	YLPM1_ENST00000552421.1_Missense_Mutation_p.W1395R	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1906					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		TTAGGTCAGATGGGCAGACCT	0.458000													15	70					0	0	1	0	0
KCTD15	79047	broad.mit.edu	37	19	34302347	34302347	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:34302347C>T	ENST00000284006.5	+	6	835	c.583C>T	c.(583-585)Ccc>Tcc	p.P195S	KCTD15_ENST00000430256.2_Missense_Mutation_p.P195S|KCTD15_ENST00000588881.1_Missense_Mutation_p.P195S|KCTD15_ENST00000589786.1_Missense_Mutation_p.P195S	NM_001129994.1|NM_001129995.1|NM_024076.2	NP_001123466.1|NP_001123467.1|NP_076981.2	Q96SI1	KCD15_HUMAN	potassium channel tetramerization domain containing 15	195						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|lung(2)|pancreas(1)|urinary_tract(1)	5	Esophageal squamous(110;0.162)					GGAGGTCTTCCCCGAGACCGG	0.672000													3	15					0	0	1	0	0
NOS1AP	9722	broad.mit.edu	37	1	162336962	162336962	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:162336962C>T	ENST00000493151.1	+	2	2708	c.341C>T	c.(340-342)gCt>gTt	p.A114V	NOS1AP_ENST00000361897.5_Missense_Mutation_p.A409V|NOS1AP_ENST00000454693.1_3'UTR|NOS1AP_ENST00000530878.1_Missense_Mutation_p.A404V|RP11-565P22.6_ENST00000431696.1_Missense_Mutation_p.A95V	NM_001126060.1	NP_001119532.2	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	409	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GCGGGCTTGGCTGACTTTGCC	0.677000													24	80					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54847647	54847647	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:54847647G>A	ENST00000545554.1	+	28	5895	c.5895G>A	c.(5893-5895)gaG>gaA	p.E1965E	UNC13C_ENST00000260323.11_Silent_p.E1965E|UNC13C_ENST00000537900.1_Silent_p.E1963E			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1965	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TGATTCGAGAGGATGCCAGGG	0.413000													4	25					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56587201	56587201	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:56587201C>G	ENST00000336078.4	+	4	2458	c.1682C>G	c.(1681-1683)tCg>tGg	p.S561W	ZNF532_ENST00000589288.1_Missense_Mutation_p.S561W|ZNF532_ENST00000591230.1_Missense_Mutation_p.S561W|ZNF532_ENST00000591083.1_Missense_Mutation_p.S561W|ZNF532_ENST00000591808.1_Missense_Mutation_p.S561W	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	561					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						GCAGCAGCCTCGCAACCCCCC	0.527000													4	19					0	0	1	0	0
VPS16	64601	broad.mit.edu	37	20	2841901	2841901	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr20:2841901C>T	ENST00000380445.3	+	8	856	c.784C>T	c.(784-786)Cgg>Tgg	p.R262W	VPS16_ENST00000481812.2_3'UTR|VPS16_ENST00000380469.3_Missense_Mutation_p.R262W	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	262					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						CTGCAACATCCGGGCACCTCC	0.527000													9	63					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92102788	92102788	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:92102788C>T	ENST00000256343.3	-	17	1879	c.1723G>A	c.(1723-1725)Gga>Aga	p.G575R		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	575					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				ATCACTTTTCCATAGTGTATA	0.368000													12	112					0	0	1	0	0
B3GALTL	145173	broad.mit.edu	37	13	31903733	31903733	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:31903733C>T	ENST00000343307.4	+	15	1574	c.1425C>T	c.(1423-1425)ttC>ttT	p.F475F		NM_194318.3	NP_919299.3	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	475					fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		AGGTGTATTTCACATGGTTGG	0.507000													11	81					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47385128	47385128	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:47385128C>T	ENST00000232766.5	+	10	1442	c.1422C>T	c.(1420-1422)tcC>tcT	p.S474S	KLHL18_ENST00000455924.2_Silent_p.S362S	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	474										endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		GAGCCGCCTCCCTGGGGAGCA	0.617000													6	54					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72307197	72307197	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:72307197C>T	ENST00000263563.6	+	18	2525	c.2257C>T	c.(2257-2259)Cgc>Tgc	p.R753C		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CTGCACCTACCGCCAGGTGAG	0.647000													11	39					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73062663	73062663	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:73062663G>A	ENST00000429829.1	-	0	9925					NR_001564.2																						AAGGGAAGAGGGAGACAGCAC	0.488000													6	41					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49131968	49131968	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49131968G>A	ENST00000443164.1	+	5	1794	c.1089G>A	c.(1087-1089)ttG>ttA	p.L363L	SPHK2_ENST00000598088.1_Silent_p.L301L|SPHK2_ENST00000340932.3_Intron|SPHK2_ENST00000245222.4_Silent_p.L301L|SPHK2_ENST00000600537.1_Silent_p.L242L|SPHK2_ENST00000599029.1_Silent_p.L265L|SPHK2_ENST00000599748.1_Silent_p.L265L			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	301					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		TCGACCTGTTGCTCAACTGCT	0.612000													5	66					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123844903	123844903	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:123844903C>T	ENST00000369005.1	+	4	3228	c.2888C>T	c.(2887-2889)cCt>cTt	p.P963L	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.P963L|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515273.1_Missense_Mutation_p.P963L|TACC2_ENST00000515603.1_Missense_Mutation_p.P963L|TACC2_ENST00000453444.2_Missense_Mutation_p.P963L	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	963						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGGGTCTCGCCTCCAGCAGCA	0.542000													22	105					0	0	1	0	0
ZNF90	7643	broad.mit.edu	37	19	20229662	20229662	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:20229662C>T	ENST00000418063.2	+	4	1411	c.1299C>T	c.(1297-1299)gtC>gtT	p.V433V	ZNF90_ENST00000474284.1_Intron	NM_007138.1	NP_009069.1	Q03938	ZNF90_HUMAN	zinc finger protein 90	433						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|lung(2)|ovary(1)|skin(1)	5						GTGACAAAGTCTTCAAACGCT	0.413000													8	38					0	0	1	0	0
FGFBP1	9982	broad.mit.edu	37	4	15938092	15938092	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:15938092C>T	ENST00000382333.1	-	3	458	c.164G>A	c.(163-165)gGg>gAg	p.G55E	FGFBP1_ENST00000259988.2_Missense_Mutation_p.G55E	NM_005130.4	NP_005121.1	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	55					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|prostate(2)|skin(1)	10						GCCTTTGTTCCCGGGCCTGCT	0.493000													25	129					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95791108	95791108	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:95791108T>A	ENST00000260766.3	+	2	939	c.305T>A	c.(304-306)cTt>cAt	p.L102H	PLCE1_ENST00000371380.2_Missense_Mutation_p.L102H	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	102					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GCGAAAAACCTTAACATTAAC	0.383000													22	71					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222866	140222866	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140222866C>T	ENST00000531613.1	+	1	1960	c.1960C>T	c.(1960-1962)Cat>Tat	p.H654Y	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.H654Y|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGAAGGATCATGGTGAACC	0.652000													15	78					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179612217	179612217	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179612217G>A	ENST00000360870.5	-	46	15132	c.14910C>T	c.(14908-14910)tcC>tcT	p.S4970S	TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	1083	Ig-like 30.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACACCAATGGAAATGTCAG	0.408000													25	119					0	0	1	0	0
NEDD1	121441	broad.mit.edu	37	12	97328853	97328853	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:97328853C>T	ENST00000266742.4	+	7	928	c.589C>T	c.(589-591)Cca>Tca	p.P197S	NEDD1_ENST00000555114.1_3'UTR|NEDD1_ENST00000557644.1_Missense_Mutation_p.P204S|NEDD1_ENST00000457368.2_Missense_Mutation_p.P108S|NEDD1_ENST00000429527.2_Missense_Mutation_p.P197S|NEDD1_ENST00000411739.2_Missense_Mutation_p.P108S	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	197					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol				breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						TAGTCAGAGTCCATACCATAA	0.413000													24	125					0	0	1	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178834383	178834383	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:178834383C>T	ENST00000234816.2	-	3	976	c.529G>A	c.(529-531)Gtg>Atg	p.V177M	ANGPTL1_ENST00000367629.1_Missense_Mutation_p.V177M|RALGPS2_ENST00000367634.2_Intron|RALGPS2_ENST00000324778.4_Intron|RALGPS2_ENST00000367635.3_Intron	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	177						extracellular space	receptor binding			breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						GCGTATTTCACCTCTAGTTCC	0.403000													13	48					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39247144	39247144	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:39247144C>T	ENST00000518318.2	+	4	478	c.436C>T	c.(436-438)Ctc>Ttc	p.L146F	POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_Missense_Mutation_p.L146F|POU6F2_ENST00000559001.1_Missense_Mutation_p.L138F			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	146					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						AACAGCGAATCTCACCAACAT	0.562000													9	70					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72674276	72674276	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:72674276C>T	ENST00000373514.2	+	3	710	c.710C>T	c.(709-711)tCc>tTc	p.S237F		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	237						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					AAGAAAATCTCCCAGTTTGAG	0.448000													8	22					0	0	1	0	0
RPAP2	79871	broad.mit.edu	37	1	92772800	92772800	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:92772800C>T	ENST00000370343.3	+	6	564	c.455C>T	c.(454-456)cCc>cTc	p.P152L	RPAP2_ENST00000484158.1_3'UTR	NM_024813.2	NP_079089.2	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	152						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	22		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		GCACAAATTCCCAAAACTCCA	0.284000													9	49					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476830	120476830	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:120476830G>A	ENST00000355622.6	+	3	2525	c.2424G>A	c.(2422-2424)tgG>tgA	p.W808*	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Nonsense_Mutation_p.W768*	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	808	TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity	p.W808F(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						ACATCTTCTGGAGACGACTCA	0.537000													10	89					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141526828	141526828	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:141526828C>A	ENST00000389484.3	-	35	6683	c.5712G>T	c.(5710-5712)atG>atT	p.M1904I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1904					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGATATAGGCATCAAAGCAT	0.353000										TSP Lung(27;0.18)			8	64					0.00448238	0.00451334	1	1	0
SGCZ	137868	broad.mit.edu	37	8	14022179	14022179	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:14022179A>T	ENST00000382080.1	-	5	1172	c.457T>A	c.(457-459)Ttt>Att	p.F153I	RP11-3G21.1_ENST00000527110.1_RNA|SGCZ_ENST00000421524.2_Missense_Mutation_p.F106I	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	140					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTCACTTCAAATCTTTTACAC	0.413000													11	66					0	0	1	0	0
DDA1	79016	broad.mit.edu	37	19	17425186	17425186	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:17425186C>T	ENST00000359866.4	+	3	248	c.124C>T	c.(124-126)Ccg>Tcg	p.P42S		NM_024050.5	NP_076955.1	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1	42										kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4						CCGCGAGTACCCGTCTGAACA	0.612000													8	56					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79321756	79321756	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:79321756C>T	ENST00000428286.1	-	8	5557	c.4357G>A	c.(4357-4359)Gaa>Aaa	p.E1453K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E1812K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1812					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GAATTATCTTCGTTCTTTGGG	0.468000													6	22					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	3030098	3030098	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:3030098C>T	ENST00000397461.1	+	13	1812	c.1428C>T	c.(1426-1428)acC>acT	p.T476T	CNTN4_ENST00000397459.2_Silent_p.T148T|CNTN4_ENST00000418658.1_Silent_p.T476T|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000448906.2_Silent_p.T148T|CNTN4_ENST00000358480.3_Silent_p.T257T|CNTN4_ENST00000427331.1_Silent_p.T476T	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	476	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GGAGTTATACCTGTATAGCCA	0.363000													17	66					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13056097	13056097	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:13056097C>T	ENST00000506447.1	+	19	3588	c.3508C>T	c.(3508-3510)Ctg>Ttg	p.L1170L	CEP192_ENST00000430049.2_Silent_p.L695L|CEP192_ENST00000325971.8_Silent_p.L574L	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	765										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GCTGGCTCTCCTGGGCAAGTC	0.502000													12	30					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83455798	83455798	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:83455798C>T	ENST00000334574.8	-	2	526	c.345G>A	c.(343-345)agG>agA	p.R115R	FSD2_ENST00000541889.1_Silent_p.R115R			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	115										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						CTCTCTGCTCCCTGGCTGGGT	0.542000													15	88					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89938757	89938757	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:89938757G>A	ENST00000405460.2	+	13	2548	c.2452G>A	c.(2452-2454)Gat>Aat	p.D818N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	818					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGAGCCAAGAGATAGCAATGA	0.433000													19	92					0	0	1	0	0
P2RX1	5023	broad.mit.edu	37	17	3806589	3806589	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:3806589G>A	ENST00000225538.3	-	7	928	c.654C>T	c.(652-654)ctC>ctT	p.L218L		NM_002558.2	NP_002549.1	P51575	P2RX1_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 1	218					platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	13				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		TCTTGTGAAAGAGGCAGGTCT	0.597000													6	24					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230231809	230231809	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:230231809C>T	ENST00000341772.4	-	12	2016	c.1882G>A	c.(1882-1884)Gcg>Acg	p.A628T		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	628					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AGGCTCTCCGCCATGTGCCCG	0.512000													6	24					0	0	1	0	0
VSNL1	7447	broad.mit.edu	37	2	17773476	17773476	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:17773476C>T	ENST00000406397.1	+	2	660	c.135C>T	c.(133-135)ctC>ctT	p.L45L	VSNL1_ENST00000295156.4_Silent_p.L45L|VSNL1_ENST00000404666.2_Silent_p.L45L			P62760	VISL1_HUMAN	visinin-like 1	45	EF-hand 1.						calcium ion binding			NS(1)|breast(1)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGCTAAATCTCGAGGAATTTC	0.428000													32	135					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021874	132021874	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:132021874C>T	ENST00000356920.5	+	15	2940	c.2846C>T	c.(2845-2847)aCc>aTc	p.T949I	PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	949	Actin-like.						ATP binding										CAGGTCATCACCATCGGCAAC	0.607000													11	120					0	0	1	0	0
ECM1	1893	broad.mit.edu	37	1	150482592	150482592	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:150482592C>T	ENST00000369047.4	+	5	444	c.319C>T	c.(319-321)Cct>Tct	p.P107S	ECM1_ENST00000346569.6_Missense_Mutation_p.P107S|ECM1_ENST00000470432.1_3'UTR|ECM1_ENST00000369049.4_Missense_Mutation_p.P134S	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	107					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TCCCCCTCTCCCTCAGGAAGC	0.567000													17	157					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457804	45457804	+	RNA	SNP	T	T	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:45457804T>A	ENST00000548424.1	+	0	448																											CATCTGTGATTTCTGCTGCTT	0.443000													25	120					0	0	1	0	0
MFSD6L	162387	broad.mit.edu	37	17	8700744	8700744	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:8700744A>C	ENST00000329805.4	-	1	1923	c.1695T>G	c.(1693-1695)agT>agG	p.S565R		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	565						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						GCTCAGAGTCACTGGTGTCAC	0.562000													11	67					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810341	106810341	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:106810341G>A	ENST00000526355.1	-	4	1519	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*	GUCY1A2_ENST00000282249.2_Nonsense_Mutation_p.R351*|GUCY1A2_ENST00000347596.2_Nonsense_Mutation_p.R351*	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	351					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GTGTCACATCGAAGCTGCTTC	0.473000													15	52					0	0	1	0	0
IGKV1-9	28941	broad.mit.edu	37	2	89309733	89309733	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:89309733G>A	ENST00000493819.1	-	0	154																											GATGCAGACAGGAAGGATGGA	0.458000													44	238					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81625493	81625493	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:81625493C>T	ENST00000558726.1	-	22	2708	c.2573G>A	c.(2572-2574)cGa>cAa	p.R858Q	TMC3_ENST00000359440.5_Missense_Mutation_p.R857Q|RP11-761I4.3_ENST00000560973.1_RNA|RP11-761I4.3_ENST00000560851.1_RNA|RP11-761I4.3_ENST00000559781.1_RNA			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	857						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						AAAGTCTTTTCGGAAAAGAGG	0.527000													17	106					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67264052	67264052	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:67264052C>T	ENST00000258201.4	-	20	3378	c.3131G>A	c.(3130-3132)cGg>cAg	p.R1044Q	FHOD1_ENST00000567687.1_Missense_Mutation_p.R623Q	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1044					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		AGCATCTCCCCGGCCTGGCCC	0.597000													16	81					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46911850	46911850	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:46911850G>A	ENST00000378623.1	-	14	2135	c.1893C>T	c.(1891-1893)caC>caT	p.H631H		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	631					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CAGCCTTACGGTGACTCCCAT	0.597000											OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	55					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131949411	131949411	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:131949411G>A	ENST00000286355.5	-	5	3481	c.1389C>T	c.(1387-1389)gaC>gaT	p.D463D	ADCY8_ENST00000377928.3_Silent_p.D463D|RP11-737F9.1_ENST00000523318.1_RNA	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	463					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGTAGTAGCAGTCCCCCAGGA	0.498000										HNSCC(32;0.087)			7	39					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102733708	102733708	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:102733708G>A	ENST00000532855.1	-	0	1631							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	ATTACCTATGGTTTACAGATT	0.259000													3	9					0	0	1	0	0
INPP5F	22876	broad.mit.edu	37	10	121551083	121551083	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:121551083C>T	ENST00000361976.2	+	4	536	c.370C>T	c.(370-372)Cct>Tct	p.P124S	INPP5F_ENST00000369083.3_Missense_Mutation_p.P124S|INPP5F_ENST00000369081.1_Missense_Mutation_p.P28S	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	124							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CATACCATCTCCTGATGACTC	0.323000													7	85					0	0	1	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49654630	49654630	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:49654630C>T	ENST00000249601.4	-	10	2197	c.1901G>A	c.(1900-1902)cGa>cAa	p.R634Q	ARHGAP22_ENST00000417912.2_Missense_Mutation_p.R650Q|ARHGAP22_ENST00000374170.1_Missense_Mutation_p.R475Q|ARHGAP22_ENST00000417247.2_Missense_Mutation_p.R544Q|ARHGAP22_ENST00000477708.2_Missense_Mutation_p.R467Q|ARHGAP22_ENST00000435790.2_Missense_Mutation_p.R640Q|ARHGAP22_ENST00000374172.1_Missense_Mutation_p.R525Q	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	634					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCGGGACATTCGTTTTCTCAG	0.498000													8	48					0	0	1	0	0
OTUB1	55611	broad.mit.edu	37	11	63764668	63764668	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:63764668C>T	ENST00000541478.1	+	3	727	c.267C>T	c.(265-267)ttC>ttT	p.F89F	OTUB1_ENST00000538426.1_Silent_p.F190F|OTUB1_ENST00000428192.2_Silent_p.F190F|OTUB1_ENST00000422031.2_Silent_p.F227F|OTUB1_ENST00000543004.1_Silent_p.F199F|OTUB1_ENST00000535715.1_Silent_p.F190F|OTUB1_ENST00000543988.1_Silent_p.F160F			Q96FW1	OTUB1_HUMAN	OTU domain, ubiquitin aldehyde binding 1	190	OTU.				protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	6						GCAAGTTCTTCGAGCACTTCA	0.627000													18	81					0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83455947	83455947	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:83455947C>T	ENST00000334574.8	-	2	377	c.196G>A	c.(196-198)Gac>Aac	p.D66N	FSD2_ENST00000541889.1_Missense_Mutation_p.D66N			A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing 2	66										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						TCTTGAAGGTCTCTTTGAGCC	0.443000													28	153					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72307196	72307196	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:72307196C>T	ENST00000263563.6	+	18	2524	c.2256C>T	c.(2254-2256)taC>taT	p.Y752Y		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		TCTGCACCTACCGCCAGGTGA	0.647000													12	39					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739356	38739356	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38739356C>T	ENST00000449082.2	-	27	5354	c.5355G>A	c.(5353-5355)ctG>ctA	p.L1785L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1785					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCATCTGGATCAGTATATTTC	0.488000													19	64					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118344687	118344687	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:118344687C>T	ENST00000534358.1	+	3	2836	c.2813C>T	c.(2812-2814)tCa>tTa	p.S938L	KMT2A_ENST00000354520.4_Missense_Mutation_p.S938L|KMT2A_ENST00000389506.5_Missense_Mutation_p.S938L	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AAGTCTTCATCACATGATTCT	0.413000													17	73					0	0	1	0	0
RAC1	5879	broad.mit.edu	37	7	6426893	6426893	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:6426893C>T	ENST00000348035.4	+	2	299	c.86C>T	c.(85-87)cCt>cTt	p.P29L	RAC1_ENST00000488373.1_3'UTR|RAC1_ENST00000356142.4_Missense_Mutation_p.P29L	NM_006908.4	NP_008839.2	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	29					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			cervix(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	AATGCATTTCCTGGAGAATAT	0.353000													12	80					0	0	1	0	0
MAP7D2	256714	broad.mit.edu	37	X	20044017	20044017	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:20044017G>A	ENST00000379651.3	-	8	956	c.938C>T	c.(937-939)cCa>cTa	p.P313L	MAP7D2_ENST00000543767.1_Missense_Mutation_p.P198L|MAP7D2_ENST00000466145.1_5'UTR|MAP7D2_ENST00000379643.5_Missense_Mutation_p.P354L|MAP7D2_ENST00000443379.3_Missense_Mutation_p.P268L|MAP7D2_ENST00000452324.3_Missense_Mutation_p.P261L	NM_152780.3	NP_689993.2	Q96T17	MA7D2_HUMAN	MAP7 domain containing 2	313										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	37						AGGAGACCCTGGGTAGGGAGG	0.493000													40	105					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72255943	72255943	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:72255943C>T	ENST00000305425.4	-	2	1376	c.954G>A	c.(952-954)ggG>ggA	p.G318G	DACH1_ENST00000359684.2_Silent_p.G318G|DACH1_ENST00000313174.7_Silent_p.G318G|DACH1_ENST00000354591.4_Silent_p.G318G	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	316	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GTGGAATTATCCCAGGAGACA	0.443000													8	56					0	0	1	0	0
ORAI2	80228	broad.mit.edu	37	7	102087367	102087367	+	Silent	SNP	C	C	T	rs144660402		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:102087367C>T	ENST00000356387.2	+	4	868	c.633C>T	c.(631-633)ttC>ttT	p.F211F	ORAI2_ENST00000478730.1_Silent_p.F211F|ORAI2_ENST00000488996.1_3'UTR|ORAI2_ENST00000473939.1_Silent_p.F211F|ORAI2_ENST00000403646.3_Silent_p.F211F	NM_001126340.1|NM_001271818.1|NM_001271819.1|NM_032831.3	NP_001119812.1|NP_001258747.1|NP_001258748.1|NP_116220.1	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator 2	211						integral to membrane	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15						GCCTCATCTTCGTGGTCTTCA	0.667000													5	26					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31419781	31419781	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:31419781G>A	ENST00000389202.2	+	10	1094	c.1045G>A	c.(1045-1047)Gag>Aag	p.E349K		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	349					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CTTCCAGCACGAGATGTCCCA	0.562000													6	37					0	0	1	0	0
RIC8B	55188	broad.mit.edu	37	12	107245347	107245347	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:107245347C>T	ENST00000392837.4	+	7	1432	c.1281C>T	c.(1279-1281)ttC>ttT	p.F427F	RIC8B_ENST00000355478.2_Silent_p.F387F|RIC8B_ENST00000392839.2_Silent_p.F427F|RIC8B_ENST00000549643.1_Intron			Q9NVN3	RIC8B_HUMAN	RIC8 guanine nucleotide exchange factor B	427					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	19						CTGCTGAATTCCTTTTTGTCC	0.408000													9	48					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125879757	125879757	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:125879757C>T	ENST00000393434.2	-	2	415	c.66G>A	c.(64-66)gaG>gaA	p.E22E	ALDH1L1_ENST00000393431.2_Silent_p.E22E|ALDH1L1_ENST00000452905.2_Silent_p.E22E|ALDH1L1_ENST00000472186.1_Silent_p.E22E|ALDH1L1_ENST00000273450.3_Silent_p.E32E|ALDH1L1_ENST00000455064.2_5'UTR	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	22	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CTTCGTGGCCCTCCTTCCTCA	0.567000													11	55					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554752	140554752	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140554752G>A	ENST00000231137.3	+	1	2510	c.2336G>A	c.(2335-2337)aGg>aAg	p.R779K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		779					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCACAGGCAGGGAAGTGGAA	0.443000													19	55					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78319950	78319950	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:78319950C>T	ENST00000582970.1	+	29	7958	c.7815C>T	c.(7813-7815)atC>atT	p.I2605I	RNF213_ENST00000508628.2_Silent_p.I2654I|RNF213_ENST00000336301.6_Silent_p.I678I	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TTGAGTCCATCAGCCTAGATG	0.517000													9	79					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328094	57328094	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:57328094G>A	ENST00000326441.9	-	10	2079	c.1716C>T	c.(1714-1716)ttC>ttT	p.F572F	PEG3_ENST00000598410.1_Silent_p.F448F|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000593695.1_Silent_p.F446F|PEG3_ENST00000423103.2_Silent_p.F572F|ZIM2_ENST00000599935.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	572					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.F572L(2)		NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AACTATGAAGGAAGGTTTCCT	0.468000													19	112					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115856396	115856396	+	Missense_Mutation	SNP	C	C	T	rs141541753		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:115856396C>T	ENST00000264363.2	-	6	2180	c.1502G>A	c.(1501-1503)gGa>gAa	p.G501E		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	501	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity	p.G501E(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AAGTTCACCTCCTCTGATACT	0.383000													20	77					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160523777	160523777	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:160523777G>A	ENST00000368054.3	-	3	583	c.548C>T	c.(547-549)aCt>aTt	p.T183I	CD84_ENST00000368051.3_Missense_Mutation_p.T183I|CD84_ENST00000368047.3_5'UTR|CD84_ENST00000534968.1_Missense_Mutation_p.T69I|CD84_ENST00000368048.3_Missense_Mutation_p.T183I|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000311224.4_Missense_Mutation_p.T183I	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	183	Ig-like C2-type.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GTCCTCAGGAGTCTGGAAGAT	0.488000													23	77					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89924433	89924433	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:89924433G>A	ENST00000405460.2	+	8	1389	c.1293G>A	c.(1291-1293)gcG>gcA	p.A431A		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	431					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGTCTCTGCGAATTGGGTGT	0.418000													10	58					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113205879	113205879	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:113205879C>T	ENST00000401783.2	-	27	4921	c.4585G>A	c.(4585-4587)Gat>Aat	p.D1529N	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Missense_Mutation_p.D1529N|SVEP1_ENST00000374469.1_Missense_Mutation_p.D1506N	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1529	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AATTTCCCATCGATATAGACT	0.438000													7	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179412221	179412221	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179412221C>T	ENST00000589042.1	-	339	94356	c.94132G>A	c.(94132-94134)Gaa>Aaa	p.E31378K	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E22505K|TTN_ENST00000460472.2_Missense_Mutation_p.E22313K|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E29737K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E22438K|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E28810K|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000438095.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29737	Fibronectin type-III 129.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAAGAATATTCCATGTATTTT	0.393000													5	25					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932427	83932427	+	Missense_Mutation	SNP	C	C	T	rs149687703		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:83932427C>T	ENST00000345382.2	-	4	1661	c.1576G>A	c.(1576-1578)Gaa>Aaa	p.E526K	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.E519K	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	526					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						AATGGCATTTCGTTTGAAATG	0.488000													26	103					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369151	86369151	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:86369151G>A	ENST00000400286.2	-	2	2091	c.1493C>T	c.(1492-1494)cCt>cTt	p.P498L		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	498						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		ATTACTTACAGGTAGATGGGT	0.403000													11	73					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	54095647	54095647	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:54095647C>T	ENST00000502396.1	+	12	2886	c.2854C>T	c.(2854-2856)Ctg>Ttg	p.L952L	MLIP_ENST00000274897.5_Silent_p.L417L|MLIP_ENST00000358276.5_Intron|MLIP_ENST00000370876.2_Intron|MLIP_ENST00000370877.2_Intron|MLIP_ENST00000509997.1_Intron			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	417						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						CTTCAGTCATCTGTCCTTCTC	0.488000													40	192					0	0	1	0	0
CBX7	23492	broad.mit.edu	37	22	39534665	39534665	+	Silent	SNP	C	C	T	rs150449795		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:39534665C>T	ENST00000216133.5	-	4	427	c.222G>A	c.(220-222)ccG>ccA	p.P74P	CBX7_ENST00000401405.3_Silent_p.P74P|RP4-742C19.8_ENST00000430647.1_RNA|CBX7_ENST00000475962.1_Intron	NM_175709.3	NP_783640.1	O95931	CBX7_HUMAN	chromobox homolog 7	74					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7	Melanoma(58;0.04)					GCTTGGGTTTCGGACCTCTCT	0.582000													16	84					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46780502	46780502	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:46780502G>A	ENST00000262738.3	-	20	6820	c.6821C>T	c.(6820-6822)cCc>cTc	p.P2274L		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	2274					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CAGCTCCCTGGGGAACTCTTC	0.542000													4	28					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162180	90162180	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:90162180C>T	ENST00000564451.1	+	0	1533				TUBB8P7_ENST00000567960.1_RNA																							CCTGTGACCCCCGTCATGGCC	0.562000													9	63					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142606682	142606682	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:142606682G>A	ENST00000265310.1	-	14	2217	c.1869C>T	c.(1867-1869)ttC>ttT	p.F623F		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	623					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CCCCCAGCCCGAATTCGCACC	0.617000													8	61					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141600146	141600146	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:141600146G>A	ENST00000442267.2	-	5	875	c.801C>T	c.(799-801)tcC>tcT	p.S267S		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	267						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				GTTTGGGCAGGGATCGATCTT	0.418000													45	177					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18692074	18692074	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:18692074G>A	ENST00000251296.1	+	6	1281	c.898G>A	c.(898-900)Gaa>Aaa	p.E300K		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	300						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CGGCACTGTGGAAGTACGTGC	0.642000													22	92					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152882347	152882347	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:152882347C>T	ENST00000368764.3	+	2	138	c.74C>T	c.(73-75)cCt>cTt	p.P25L	IVL_ENST00000392667.2_5'UTR			P07476	INVO_HUMAN	involucrin	25					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACTGTTCCTCCTCCAGTCAAT	0.552000													26	64					0	0	1	0	0
P2RY14	9934	broad.mit.edu	37	3	150931563	150931563	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:150931563C>T	ENST00000309170.3	-	3	854	c.542G>A	c.(541-543)cGg>cAg	p.R181Q	MED12L_ENST00000273432.4_Intron|P2RY14_ENST00000424796.2_Missense_Mutation_p.R181Q|MED12L_ENST00000474524.1_Intron	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	181						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGCCACTTCCGTCCCAGTTC	0.383000													11	135					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9982316	9982316	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:9982316G>A	ENST00000506583.1	-	7	711	c.494C>T	c.(493-495)cCc>cTc	p.P165L	SLC2A9_ENST00000309065.3_Missense_Mutation_p.P165L|SLC2A9_ENST00000264784.3_Missense_Mutation_p.P194L			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	194					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						GATCTCCTTGGGTGAGATCTC	0.582000													10	44					0	0	1	0	0
FAM92A1P2	403315	broad.mit.edu	37	4	183960166	183960166	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:183960166C>T	ENST00000502308.1	+	0	1349					NR_003612.1																						CACCAGAGATCATGTCAGCTA	0.388000													4	44					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45459108	45459108	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:45459108C>T	ENST00000548424.1	+	0	448																											CAAACAGATTCCGCATATTCA	0.483000													6	40					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75276590	75276590	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:75276590G>A	ENST00000339859.4	-	19	3694	c.3594C>T	c.(3592-3594)tcC>tcT	p.S1198S	USP54_ENST00000422491.2_Silent_p.S380S|USP54_ENST00000408019.1_Silent_p.S1198S|RP11-137L10.6_ENST00000600206.1_RNA|RP11-137L10.6_ENST00000597958.1_RNA|RP11-137L10.6_ENST00000595069.1_RNA|USP54_ENST00000394811.2_Silent_p.S286S|USP54_ENST00000428547.1_Silent_p.S1048S|USP54_ENST00000497106.1_5'UTR|RP11-137L10.6_ENST00000593790.1_RNA			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1198					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					ACTCTTCCCAGGAAAGTGGTC	0.522000													26	209					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39226570	39226570	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:39226570C>T	ENST00000340369.3	-	2	4595	c.4367G>A	c.(4366-4368)gGg>gAg	p.G1456E	XIRP1_ENST00000421646.1_Missense_Mutation_p.G139E|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1456							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CTCAGGGGCCCCTTGGTGGGA	0.627000													19	87					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49049985	49049985	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:49049985C>T	ENST00000395474.3	+	2	1388	c.1108C>T	c.(1108-1110)Ctc>Ttc	p.L370F	WDR6_ENST00000415265.2_Intron|WDR6_ENST00000489684.1_3'UTR|WDR6_ENST00000448293.1_Missense_Mutation_p.L289F	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	340					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		GGTCTCGGCTCTCTGCTTCAA	0.607000													16	67					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21078644	21078644	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:21078644G>A	ENST00000261383.3	-	24	3477	c.3478C>T	c.(3478-3480)Ctg>Ttg	p.L1160L	DNAH3_ENST00000415178.1_Silent_p.L1160L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1160	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TAATCATTCAGCCCTTTCTGG	0.448000													10	66					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38904066	38904066	+	Silent	SNP	A	A	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:38904066A>T	ENST00000274276.3	+	8	1476	c.1074A>T	c.(1072-1074)atA>atT	p.I358I		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	358	Fibronectin type-III 1.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TGCACTCCATAAGGAATAATT	0.313000													8	28					0	0	1	0	0
WNT1	7471	broad.mit.edu	37	12	49374390	49374390	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:49374390G>C	ENST00000293549.3	+	3	578	c.542G>C	c.(541-543)gGc>gCc	p.G181A		NM_005430.3	NP_005421.1	P04628	WNT1_HUMAN	wingless-type MMTV integration site family, member 1	181					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(357;0.244)		CGCCTCTTCGGCCGGGAGTTC	0.667000													4	15					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87679330	87679330	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:87679330G>A	ENST00000320005.5	-	6	722	c.675C>T	c.(673-675)gtC>gtT	p.V225V		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	225					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						AGGCAAGAGTGACAAGCAAGA	0.433000													11	35					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38781078	38781078	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38781078G>A	ENST00000449082.2	-	14	2207	c.2208C>T	c.(2206-2208)atC>atT	p.I736I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	736					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCACAGTGACGATGATGCAGT	0.453000													8	48					0	0	1	0	0
NAT9	26151	broad.mit.edu	37	17	72769804	72769804	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:72769804G>A	ENST00000357814.3	-	3	174	c.101C>T	c.(100-102)tCa>tTa	p.S34L	NAT9_ENST00000580216.1_5'UTR|NAT9_ENST00000582870.1_Missense_Mutation_p.S38L|NAT9_ENST00000578822.1_Missense_Mutation_p.S39L|NAT9_ENST00000580301.1_Missense_Mutation_p.S33L|NAT9_ENST00000583476.1_Missense_Mutation_p.S34L|NAT9_ENST00000581136.1_Missense_Mutation_p.S34L|NAT9_ENST00000580632.1_Missense_Mutation_p.S33L|NAT9_ENST00000583757.1_Missense_Mutation_p.S33L|NAT9_ENST00000582524.1_Missense_Mutation_p.S34L	NM_015654.3	NP_056469.2	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9 (GCN5-related, putative)	34						protein complex	N-acetyltransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)	8						CAGCTCCTCTGATTTCATCCA	0.567000													29	89					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114296129	114296129	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:114296129G>A	ENST00000309235.5	+	4	770	c.612G>A	c.(610-612)agG>agA	p.R204R	ZNF483_ENST00000358151.4_Silent_p.R204R|ZNF483_ENST00000355824.3_Silent_p.R204R	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	204	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						AAAACCTCAGGAACCTAGAAT	0.408000													25	109					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4889566	4889566	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:4889566G>A	ENST00000361571.5	-	2	432	c.21C>T	c.(19-21)tcC>tcT	p.S7S	CAMTA2_ENST00000348066.3_5'UTR|CAMTA2_ENST00000381311.5_Intron|CAMTA2_ENST00000358183.4_5'UTR|CAMTA2_ENST00000572543.1_5'UTR|CAMTA2_ENST00000414043.3_Silent_p.S7S	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	472					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GGGGCCGGGGGGAGGGGGAGT	0.582000													4	13					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124090761	124090761	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:124090761C>T	ENST00000368994.2	+	12	1328	c.1077C>T	c.(1075-1077)aaC>aaT	p.N359N	BTBD16_ENST00000260723.4_Silent_p.N358N			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	358										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				TTACAGTCAACCATTACCACG	0.463000													8	59					0	0	1	0	0
LPAL2	80350	broad.mit.edu	37	6	160913983	160913983	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:160913983G>A	ENST00000335388.5	-	0	337					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GCAGTAGTTCGAGATCAAGCC	0.493000													17	102					0	0	1	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670364	131670364	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:131670364C>T	ENST00000259324.5	+	3	1444	c.921C>T	c.(919-921)acC>acT	p.T307T	LRRC8A_ENST00000372600.4_Silent_p.T307T|LRRC8A_ENST00000372599.3_Silent_p.T307T	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	307					pre-B cell differentiation	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						GCTACCGCACCTACCGCTGTG	0.542000													15	119					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128984557	128984557	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:128984557C>T	ENST00000314797.6	+	14	1494	c.1390C>T	c.(1390-1392)Ccc>Tcc	p.P464S		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	464					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										CCAGGAGGGGCCCAAGACCAC	0.572000													8	59					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56474102	56474102	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:56474102C>T	ENST00000370754.5	-	39	5224	c.5225G>A	c.(5224-5226)gGa>gAa	p.G1742E	DST_ENST00000421834.2_Intron|DST_ENST00000312431.6_Missense_Mutation_p.G1564E|DST_ENST00000244364.6_Intron|DST_ENST00000361203.3_Missense_Mutation_p.G1564E|DST_ENST00000446842.2_Missense_Mutation_p.G1238E|DST_ENST00000370788.2_Intron|DST_ENST00000370769.4_Missense_Mutation_p.G1564E			Q03001	DYST_HUMAN	dystonin	1564					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AAGGACTTCTCCAGTTGTCTG	0.423000													44	194					0	0	1	0	0
GPR183	1880	broad.mit.edu	37	13	99948259	99948259	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:99948259C>T	ENST00000376414.4	-	2	224	c.141G>A	c.(139-141)gtG>gtA	p.V47V	UBAC2_ENST00000376440.2_Intron|UBAC2_ENST00000403766.3_Intron	NM_004951.4	NP_004942.1	P32249	GP183_HUMAN	G protein-coupled receptor 183	47					humoral immune response|mature B cell differentiation involved in immune response	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			cervix(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	23						GTAAGTTTCCCACGAGCCCAA	0.428000													15	85					0	0	1	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1816234	1816234	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:1816234C>T	ENST00000250894.4	+	22	2797	c.2640C>T	c.(2638-2640)acC>acT	p.T880T	MAPK8IP3_ENST00000356010.5_Silent_p.T874T	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	880					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						AGGTGGCCACCATCGCCAACG	0.647000													11	53					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105405110	105405110	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:105405110C>T	ENST00000351513.2	-	8	1477	c.1345G>A	c.(1345-1347)Gaa>Aaa	p.E449K	DPYS_ENST00000521601.1_Intron	NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	449					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ACTCCGGCTTCATATACCACT	0.453000													32	138					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139272466	139272466	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:139272466C>T	ENST00000298532.2	-	21	4181	c.3813G>A	c.(3811-3813)ctG>ctA	p.L1271L		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	1271					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		ACAGCAGGCCCAGGTCCAGGG	0.721000													4	10					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41319823	41319823	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:41319823G>A	ENST00000361937.3	-	25	3443	c.3019C>T	c.(3019-3021)Cca>Tca	p.P1007S	INO80_ENST00000401393.3_Missense_Mutation_p.P1007S|RP11-540O11.4_ENST00000560178.1_RNA			Q9ULG1	INO80_HUMAN	INO80 complex subunit	1007	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						AAAAAAGATGGCAGCTCAGTG	0.498000													10	50					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154525457	154525457	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:154525457C>T	ENST00000409663.3	+	25	3342	c.3290C>T	c.(3289-3291)gCc>gTc	p.A1097V	KIAA0922_ENST00000409959.3_Missense_Mutation_p.A1098V|KIAA0922_ENST00000440693.1_Missense_Mutation_p.A1014V	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	1097						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				GAGAACACAGCCGAGTTCAAG	0.423000													14	66					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99725877	99725877	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:99725877G>A	ENST00000393483.3	-	6	870	c.26C>T	c.(25-27)cCa>cTa	p.P9L	TSGA10_ENST00000355053.4_Missense_Mutation_p.P9L|TSGA10_ENST00000542655.1_Missense_Mutation_p.P9L|TSGA10_ENST00000410001.1_Missense_Mutation_p.P9L|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000539964.1_Missense_Mutation_p.P9L	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	9					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						TGGGCGTCTTGGACTTTTAGA	0.388000													15	101					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11325238	11325238	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:11325238G>A	ENST00000294618.7	-	33	4205	c.4194C>T	c.(4192-4194)atC>atT	p.I1398I	DOCK6_ENST00000319867.7_Silent_p.I737I|CTC-510F12.2_ENST00000588634.1_RNA	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1398					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CCTGCACGATGATCTCCAGTG	0.557000													17	36					0	0	1	0	0
MBTPS1	8720	broad.mit.edu	37	16	84129265	84129265	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:84129265G>A	ENST00000343411.3	-	4	1062	c.567C>T	c.(565-567)atC>atT	p.I189I		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	189					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						CCTGGCGCGGGATGGCTCTCA	0.587000													13	98					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5235132	5235132	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:5235132C>T	ENST00000274181.7	+	13	1994	c.1856C>T	c.(1855-1857)tCg>tTg	p.S619L		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	619	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TCCAGGCCATCGCATGGAGGG	0.428000													6	70					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	A	rs121913500		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:209113112C>A	ENST00000415913.1	-	4	776	c.395G>T	c.(394-396)cGt>cTt	p.R132L	IDH1_ENST00000345146.2_Missense_Mutation_p.R132L|IDH1_ENST00000446179.1_Missense_Mutation_p.R132L			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								20	56					1.01871e-10	1.03866e-10	1	1	0
CLIC6	54102	broad.mit.edu	37	21	36079601	36079601	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:36079601C>T	ENST00000360731.3	+	3	1452	c.1452C>T	c.(1450-1452)atC>atT	p.I484I	CLIC6_ENST00000349499.2_Silent_p.I466I			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	484						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						GTGAGAGTATCGGAAATTGCC	0.438000													9	72					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42293128	42293128	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:42293128C>T	ENST00000361204.4	+	14	2734	c.2568C>T	c.(2566-2568)ccC>ccT	p.P856P	SREBF2_ENST00000491541.1_3'UTR	NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	856					cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TTATGAGCCCCCCACTCTCCA	0.527000													4	28					0	0	1	0	0
CD300LF	146722	broad.mit.edu	37	17	72699182	72699182	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:72699182C>T	ENST00000469092.1	-	4	723	c.447G>A	c.(445-447)ttG>ttA	p.L149L	CD300LF_ENST00000326165.6_Silent_p.L146L|CD300LF_ENST00000583937.1_Silent_p.L161L|CD300LF_ENST00000343125.4_Silent_p.L149L|CD300LF_ENST00000464910.1_Silent_p.L149L|CD300LF_ENST00000581500.1_Silent_p.L164L|RAB37_ENST00000340415.3_Intron|RAB37_ENST00000402449.4_Intron|CD300LF_ENST00000301573.9_Silent_p.L146L|CD300LF_ENST00000361254.4_Silent_p.L164L			Q8TDQ1	CLM1_HUMAN	CD300 molecule-like family member f	146						integral to membrane|plasma membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	12						ACCTGTTGTCCAAGTGGTGGC	0.552000													18	56					0	0	1	0	0
OR14K1	343170	broad.mit.edu	37	1	247902471	247902471	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:247902471C>T	ENST00000283225.2	+	1	555	c.555C>T	c.(553-555)ctC>ctT	p.L185L	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						TACTAAAGCTCACTTGTTCTA	0.423000													60	224					0	0	1	0	0
TMEM119	338773	broad.mit.edu	37	12	108985573	108985573	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:108985573C>T	ENST00000392806.3	-	2	755	c.587G>A	c.(586-588)gGa>gAa	p.G196E		NM_181724.2	NP_859075.2	Q4V9L6	TM119_HUMAN	transmembrane protein 119	196						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|skin(1)	7						CATCCTGGCTCCGTCCCCACC	0.677000													10	29					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45169849	45169849	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:45169849C>T	ENST00000429094.2	-	8	1351	c.847G>A	c.(847-849)Gaa>Aaa	p.E283K	NELL2_ENST00000551601.1_Missense_Mutation_p.E282K|NELL2_ENST00000437801.2_Missense_Mutation_p.E333K|NELL2_ENST00000395487.2_Missense_Mutation_p.E282K|NELL2_ENST00000333837.4_Missense_Mutation_p.E306K|NELL2_ENST00000549027.1_Missense_Mutation_p.E282K|NELL2_ENST00000452445.2_Missense_Mutation_p.E283K	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	283	VWFC 1.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GACTCAAATTCTCGGTAGGTG	0.458000													6	60					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96829085	96829085	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:96829085C>T	ENST00000371270.3	-	1	169	c.75G>A	c.(73-75)agG>agA	p.R25R	CYP2C8_ENST00000535898.1_5'UTR|CYP2C8_ENST00000539050.1_5'UTR	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	25					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GCTTCCTTCTCCTACAGCTCT	0.433000													21	70					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94039091	94039091	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:94039091C>T	ENST00000297268.6	+	19	1464	c.993C>T	c.(991-993)ggC>ggT	p.G331G		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	331			G -> D (in OI3).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GTATTCCTGGCCCTGTTGGTG	0.582000										HNSCC(75;0.22)			9	67					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21224993	21224993	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:21224993G>T	ENST00000233242.1	-	29	13428	c.13301C>A	c.(13300-13302)tCc>tAc	p.S4434Y		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4434					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGAGAGTTGGGAAGTAAAGTT	0.378000													13	72					7.03913e-09	7.16693e-09	1	1	0
COL6A3	1293	broad.mit.edu	37	2	238249693	238249693	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:238249693G>A	ENST00000295550.4	-	38	8318	c.7866C>T	c.(7864-7866)ttC>ttT	p.F2622F	COL6A3_ENST00000409809.1_Silent_p.F2416F|COL6A3_ENST00000353578.4_Silent_p.F2416F|COL6A3_ENST00000347401.3_Silent_p.F2421F|COL6A3_ENST00000346358.4_Silent_p.F2422F|COL6A3_ENST00000472056.1_Silent_p.F2015F	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2622	Nonhelical region.|VWFA 12.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGTCTAAGATGAAAGCCATGT	0.532000													26	120					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14954331	14954331	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrY:14954331C>T	ENST00000338981.3	+	38	7323	c.6378C>T	c.(6376-6378)caC>caT	p.H2126H	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	2126					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TTATTGCACACTTTTCCTTGC	0.388000													25	59					0	0	1	0	0
LHX4	89884	broad.mit.edu	37	1	180243486	180243486	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:180243486C>T	ENST00000263726.2	+	6	1189	c.945C>T	c.(943-945)tcC>tcT	p.S315S	RP5-1180C10.2_ENST00000415414.1_RNA|RP5-1180C10.2_ENST00000440959.2_RNA	NM_033343.3	NP_203129.1	Q969G2	LHX4_HUMAN	LIM homeobox 4	315						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)	16						AGTCTCCATCCTCCATATCGT	0.547000													61	157					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95523659	95523659	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:95523659G>A	ENST00000297591.5	-	13	3219	c.3144C>T	c.(3142-3144)ccC>ccT	p.P1048P	KIAA1429_ENST00000437199.1_Silent_p.P1048P|KIAA1429_ENST00000523405.1_5'UTR|KIAA1429_ENST00000421249.2_Silent_p.P1048P	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	1048					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			GACCTGAGAGGGGGATAGAGC	0.393000													4	40					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56329469	56329469	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:56329469C>T	ENST00000443188.1	-	4	782	c.72G>A	c.(70-72)caG>caA	p.Q24Q	NLRP11_ENST00000589093.1_Silent_p.Q24Q|NLRP11_ENST00000592953.1_Intron|NLRP11_ENST00000589824.2_Silent_p.Q24Q|NLRP11_ENST00000360133.3_Silent_p.Q24Q	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	24	DAPIN.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TCTTAAAACTCTGAAATTCCT	0.433000													12	72					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983703	123983703	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:123983703G>A	ENST00000306315.5	-	4	2809	c.2374C>T	c.(2374-2376)Ccc>Tcc	p.P792S	ZNF608_ENST00000504926.1_Missense_Mutation_p.P365S	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	792						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		ATAATTGTGGGCTTTGGTTGA	0.488000													13	101					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68673685	68673685	+	Missense_Mutation	SNP	C	C	T	rs145237838		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:68673685C>T	ENST00000255078.3	+	2	346	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	IGHMBP2_ENST00000539224.1_Missense_Mutation_p.P79S	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	79					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGCAGCTCTTCCCAGTAACAG	0.537000													18	63					0	0	1	0	0
USP5	8078	broad.mit.edu	37	12	6972536	6972536	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:6972536C>T	ENST00000229268.8	+	15	2001	c.1949C>T	c.(1948-1950)cCg>cTg	p.P650L	USP5_ENST00000541969.1_3'UTR|USP5_ENST00000389231.5_Intron	NM_001098536.1	NP_001092006.1	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 (isopeptidase T)	650					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(6)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|skin(2)|urinary_tract(2)	36						TTCTCCTCTCCGACATGTTAG	0.567000													11	100					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70048709	70048709	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:70048709T>A	ENST00000330891.5	-	10	2211	c.1985A>T	c.(1984-1986)gAa>gTa	p.E662V	BEST3_ENST00000553096.1_Missense_Mutation_p.E556V|BEST3_ENST00000488961.1_Missense_Mutation_p.E449V|BEST3_ENST00000331471.4_Intron	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	662						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TTCCTCAGTTTCCTTGTTCAG	0.458000													8	67					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71849902	71849902	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:71849902C>T	ENST00000445078.2	+	3	257	c.186C>T	c.(184-186)tcC>tcT	p.S62S	FOLR3_ENST00000456237.1_Silent_p.S64S|FOLR3_ENST00000442948.2_Intron			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	49					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	AAGGGCCCTCCCCAGGAAGTG	0.527000													3	11					0	0	1	0	0
PRDM7	11105	broad.mit.edu	37	16	90133292	90133292	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:90133292C>T	ENST00000449207.2	-	4	347	c.328G>A	c.(328-330)Gga>Aga	p.G110R	PRDM7_ENST00000407825.1_5'UTR	NM_001098173.1	NP_001091643.1	Q9NQW5	PRDM7_HUMAN	PR domain containing 7	110						chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCTGTTCTCCTCTGAAGGCC	0.388000													35	192					0	0	1	0	0
TMEM206	55248	broad.mit.edu	37	1	212538575	212538575	+	Silent	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:212538575T>C	ENST00000261455.4	-	8	1172	c.1035A>G	c.(1033-1035)gcA>gcG	p.A345A	TMEM206_ENST00000535273.1_Silent_p.A406A	NM_018252.2	NP_060722.2	Q9H813	TM206_HUMAN	transmembrane protein 206	345						integral to membrane				breast(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	17				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		TGTGGCTCGTTGCCTGACCTC	0.418000													48	117					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52821989	52821989	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:52821989C>T	ENST00000405128.3	+	1	149	c.10C>T	c.(10-12)Ccc>Tcc	p.P4S	ITIH1_ENST00000542827.1_Intron|ITIH1_ENST00000273283.2_Intron|ITIH1_ENST00000540715.1_Intron|ITIH1_ENST00000537050.1_Intron			P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	0					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		AATGCCACTCCCCCTCCCATC	0.622000													17	112					0	0	1	0	0
UNK	85451	broad.mit.edu	37	17	73808245	73808245	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:73808245C>T	ENST00000293218.3	+	4	595	c.595C>T	c.(595-597)Cgt>Tgt	p.R199C	UNK_ENST00000589666.1_Missense_Mutation_p.R123C			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	123							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			GTACCACCTTCGTTACTACAA	0.567000													8	57					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192700687	192700687	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:192700687C>T	ENST00000304141.4	-	2	1569	c.1240G>A	c.(1240-1242)Gtg>Atg	p.V414M		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	414						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCGGGCTGCACGGGGTCCCCA	0.632000													6	61					0	0	1	0	0
PGR	5241	broad.mit.edu	37	11	100912815	100912815	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:100912815C>T	ENST00000325455.5	-	7	3960	c.2507G>A	c.(2506-2508)cGa>cAa	p.R836Q	PGR_ENST00000534013.1_Missense_Mutation_p.R242Q|PGR_ENST00000263463.5_Missense_Mutation_p.R734Q	NM_000926.4|NM_001202474.1	NP_000917.3|NP_001189403.1	P06401	PRGR_HUMAN	progesterone receptor	836	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding	p.R836Q(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	GGTTTGACTTCGTAGCCCTTC	0.383000													11	53					0	0	1	0	0
GPALPP1	55425	broad.mit.edu	37	13	45589219	45589219	+	Splice_Site	SNP	G	G	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:45589219G>C	ENST00000361121.2	+	5	575		c.e5+1		KIAA1704_ENST00000379151.4_Splice_Site|KIAA1704_ENST00000357537.3_Splice_Site|RP11-321C24.1_ENST00000437748.2_lincRNA			Q8IXQ4	K1704_HUMAN												breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|prostate(2)|skin(1)	12		Lung NSC(96;0.00143)|Prostate(109;0.0137)|Breast(139;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.133)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000313)|BRCA - Breast invasive adenocarcinoma(63;0.126)		AGGAGATGATGTAAGTTTTAA	0.274000													6	42					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50824031	50824031	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:50824031G>A	ENST00000376959.2	-	3	2152	c.1989C>T	c.(1987-1989)ccC>ccT	p.P663P	KCNC3_ENST00000474951.1_5'UTR|KCNC3_ENST00000477616.1_Silent_p.P663P|KCNC3_ENST00000391818.2_5'UTR			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	663					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GATCCCCATTGGGGCGAGGAT	0.622000													6	33					0	0	1	0	0
PLIN3	10226	broad.mit.edu	37	19	4852125	4852125	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:4852125G>A	ENST00000221957.4	-	5	713	c.537C>T	c.(535-537)tcC>tcT	p.S179S	PLIN3_ENST00000585479.1_Silent_p.S179S|PLIN3_ENST00000592528.1_Silent_p.S167S	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	179					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	GGCCCAAGCGGGAGCCCATGA	0.647000											OREG0025175	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	30					0	0	1	0	0
MURC	347273	broad.mit.edu	37	9	103348617	103348617	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:103348617C>T	ENST00000307584.5	+	2	1044	c.979C>T	c.(979-981)Cct>Tct	p.P327S		NM_001018116.1	NP_001018126.1	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	327					cell differentiation|muscle organ development|transcription, DNA-dependent					endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)	16		Acute lymphoblastic leukemia(62;0.0461)				GCCGGTGTATCCTCCCCATGA	0.493000													6	52					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220467231	220467231	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:220467231C>T	ENST00000456909.1	+	6	570	c.480C>T	c.(478-480)ctC>ctT	p.L160L	STK11IP_ENST00000459692.1_3'UTR|STK11IP_ENST00000295641.10_Silent_p.L171L			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	171					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTCTGCCCTCCCTTGGCTGG	0.597000													8	70					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43985997	43985997	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:43985997C>T	ENST00000262726.7	-	24	3242	c.2989G>A	c.(2989-2991)Gga>Aga	p.G997R	EFCAB6_ENST00000396231.2_Missense_Mutation_p.G845R	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	997	EF-hand 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				AGAGAACATCCACATTCTTCC	0.428000													27	159					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152500560	152500560	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:152500560C>T	ENST00000397345.3	-	57	7930	c.7728G>A	c.(7726-7728)tgG>tgA	p.W2576*	NEB_ENST00000603639.1_Nonsense_Mutation_p.W2576*|NEB_ENST00000604864.1_Nonsense_Mutation_p.W2576*|NEB_ENST00000172853.10_Nonsense_Mutation_p.W2576*|NEB_ENST00000409198.1_Nonsense_Mutation_p.W2576*|NEB_ENST00000427231.2_Nonsense_Mutation_p.W2576*	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	2576					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CATGCATGGACCACATCATCT	0.507000													66	398					0	0	1	0	0
OPN1LW	5956	broad.mit.edu	37	X	153416416	153416416	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:153416416C>T	ENST00000369951.4	+	2	461	c.401C>T	c.(400-402)tCc>tTc	p.S134F	OPN1LW_ENST00000463296.1_3'UTR	NM_020061.4	NP_064445.1	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	134					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TACACCGTCTCCCTGTGTGGT	0.612000													13	31					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40853702	40853702	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:40853702G>A	ENST00000255224.3	-	2	1060	c.692C>T	c.(691-693)aCc>aTc	p.T231I	SYT4_ENST00000590752.1_Missense_Mutation_p.T213I|SYT4_ENST00000586678.1_Intron	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	231	C2 1.|Phospholipid binding (Probable).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						TTGGATTTGGGTGTAGGGTAT	0.403000													16	107					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191173	152191173	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:152191173C>T	ENST00000368801.2	-	3	3007	c.2932G>A	c.(2932-2934)Ggt>Agt	p.G978S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	978					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAAGACGAACCTGAGCTAGAT	0.572000													53	389					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92307925	92307925	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:92307925G>A	ENST00000276609.3	+	4	710	c.471G>A	c.(469-471)gtG>gtA	p.V157V	SLC26A7_ENST00000523719.1_Silent_p.V157V|SLC26A7_ENST00000309536.2_Silent_p.V157V	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	157						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TGGGAGGTGTGATTCAGGTAA	0.453000													5	51					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73751729	73751729	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:73751729G>A	ENST00000342056.2	+	3	958	c.560G>A	c.(559-561)cGa>cAa	p.R187Q	KCNQ5_ENST00000414165.2_Missense_Mutation_p.R187Q|KCNQ5_ENST00000403813.2_Missense_Mutation_p.R187Q|KCNQ5_ENST00000402622.2_Missense_Mutation_p.R187Q|KCNQ5_ENST00000370392.1_Missense_Mutation_p.R187Q|KCNQ5_ENST00000370398.1_Missense_Mutation_p.R187Q|KCNQ5_ENST00000355635.3_Missense_Mutation_p.R187Q|KCNQ5_ENST00000355194.4_Missense_Mutation_p.R187Q	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	187					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TGCTGTTGTCGATATAGAGGA	0.428000													42	217					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175763826	175763826	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:175763826C>G	ENST00000443967.1	+	10	2625	c.2218C>G	c.(2218-2220)Ctg>Gtg	p.L740V	SIMC1_ENST00000430704.2_Missense_Mutation_p.L325V|SIMC1_ENST00000341199.6_Missense_Mutation_p.L325V|SIMC1_ENST00000332772.4_Missense_Mutation_p.L201V					SUMO-interacting motifs containing 1																		GCCTCTGTCTCTGGCCCAGGC	0.488000													16	71					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92526108	92526108	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:92526108G>A	ENST00000298047.6	+	8	4804	c.4787G>A	c.(4786-4788)gGa>gAa	p.G1596E	FAT3_ENST00000525166.1_Missense_Mutation_p.G1446E|FAT3_ENST00000409404.2_Missense_Mutation_p.G1596E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1596	Cadherin 15.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAAGACAAAGGAGAAAATGCA	0.443000										TCGA Ovarian(4;0.039)			8	57					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105187113	105187113	+	Silent	SNP	C	C	T	rs144287622	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:105187113C>T	ENST00000369797.3	+	21	3427	c.3333C>T	c.(3331-3333)ttC>ttT	p.F1111F		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1111					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		ACCCCAGATTCGTTCGAACCA	0.478000													35	109					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165218847	165218847	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:165218847G>A	ENST00000342310.3	-	4	676	c.294C>T	c.(292-294)ttC>ttT	p.F98F	LMX1A_ENST00000367893.4_Silent_p.F98F|LMX1A_ENST00000294816.2_Silent_p.F98F	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	98	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CGATGGCCTCGAAGCAGCCCC	0.542000													4	34					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38627269	38627269	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38627269G>A	ENST00000413689.1	-	16	2893	c.2700C>T	c.(2698-2700)atC>atT	p.I900I	SCN5A_ENST00000450102.2_Silent_p.I900I|SCN5A_ENST00000449557.2_Silent_p.I900I|SCN5A_ENST00000425664.1_Silent_p.I900I|SCN5A_ENST00000455624.2_Silent_p.I900I|SCN5A_ENST00000423572.2_Silent_p.I900I|SCN5A_ENST00000414099.2_Silent_p.I900I|SCN5A_ENST00000451551.2_Silent_p.I900I|SCN5A_ENST00000443581.1_Silent_p.I900I|SCN5A_ENST00000333535.4_Silent_p.I900I	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	900					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACATGGTCTCGATCCACTCTC	0.542000													18	83					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120197774	120197774	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:120197774G>A	ENST00000019103.5	-	13	1509	c.1242C>T	c.(1240-1242)caC>caT	p.H414H		NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	414					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	AGGCCACGGGGTGCAGTGGGA	0.632000													5	22					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296361	39296361	+	Missense_Mutation	SNP	A	A	G	rs146882220	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:39296361A>G	ENST00000345847.4	-	1	378	c.379T>C	c.(379-381)Tcc>Ccc	p.S127P		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	123	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						CAGCACTGGGACCTGCAGCAC	0.652000													4	37					0	0	1	0	0
NACAP1	83955	broad.mit.edu	37	8	102381374	102381374	+	RNA	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:102381374G>A	ENST00000419462.1	+	0	786					NR_002182.1																						GGAAGGCTAGGTTCAAACTGG	0.443000													45	214					0	0	1	0	0
FOXH1	8928	broad.mit.edu	37	8	145700115	145700115	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:145700115C>T	ENST00000377317.4	-	3	1182	c.604G>A	c.(604-606)Gag>Aag	p.E202K		NM_003923.2	NP_003914.1	O75593	FOXH1_HUMAN	forkhead box H1	202					axial mesoderm development|blood vessel development|cell migration involved in gastrulation|embryonic heart tube anterior/posterior pattern formation|floor plate formation|heart looping|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|specification of organ position|transforming growth factor beta receptor signaling pathway	activin responsive factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|R-SMAD binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.76e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGCACCGCCTCCTCCCCACTG	0.692000													3	12					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23521247	23521247	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:23521247G>A	ENST00000296682.3	+	6	649	c.467G>A	c.(466-468)gGa>gAa	p.G156E		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	156					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TCCCCTTCTGGAGAAGCAAGT	0.418000										HNSCC(3;0.000094)			13	85					0	0	1	0	0
EXOG	9941	broad.mit.edu	37	3	38545122	38545122	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:38545122C>T	ENST00000287675.5	+	4	566	c.470C>T	c.(469-471)aCc>aTc	p.T157I	EXOG_ENST00000422077.2_Missense_Mutation_p.T107I|EXOG_ENST00000358249.2_Missense_Mutation_p.T17I	NM_005107.3	NP_005098.2	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	157						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding			central_nervous_system(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	17						ATGGCTGAAACCTTTTACCTT	0.328000													13	83					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211066	38211066	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:38211066C>T	ENST00000379705.3	-	11	3765	c.2908G>A	c.(2908-2910)Gaa>Aaa	p.E970K	TRPC4_ENST00000379681.3_Missense_Mutation_p.E975K|TRPC4_ENST00000379673.2_Missense_Mutation_p.E821K|TRPC4_ENST00000338947.5_Missense_Mutation_p.E797K|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000355779.2_Missense_Mutation_p.E829K|TRPC4_ENST00000447043.1_Missense_Mutation_p.E829K|TRPC4_ENST00000379679.1_Missense_Mutation_p.E797K|TRPC4_ENST00000358477.2_Missense_Mutation_p.E886K			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	970	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity	p.E970K(1)		NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		ACGTAATCTTCGTGGGTGACT	0.433000													18	68					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179665314	179665314	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179665314G>A	ENST00000589042.1	-	4	615	c.391C>T	c.(391-393)Cct>Tct	p.P131S	TTN_ENST00000342175.6_Missense_Mutation_p.P131S|TTN_ENST00000460472.2_Missense_Mutation_p.P131S|TTN_ENST00000591111.1_Missense_Mutation_p.P131S|TTN_ENST00000360870.5_Missense_Mutation_p.P131S|TTN_ENST00000359218.5_Missense_Mutation_p.P131S|TTN_ENST00000342992.6_Missense_Mutation_p.P131S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	131	Ig-like 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGGTGTAGGGATTCCAGTC	0.517000													24	98					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222899	140222899	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140222899G>A	ENST00000531613.1	+	1	1993	c.1993G>A	c.(1993-1995)Gtt>Att	p.V665I	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.V665I|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGCCACGGTTCTGGTGTC	0.647000													14	67					0	0	1	0	0
CUZD1	50624	broad.mit.edu	37	10	124596401	124596401	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:124596401A>G	ENST00000368904.1	-	7	1712	c.763T>C	c.(763-765)Tac>Cac	p.Y255H	CUZD1_ENST00000545804.1_Missense_Mutation_p.Y255H|CUZD1_ENST00000392790.1_Missense_Mutation_p.Y255H			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	255	CUB 2.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		AATCCCCGGTAAGAATTGGCA	0.423000													31	133					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5463182	5463182	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:5463182G>A	ENST00000345221.3	-	4	1388	c.834C>T	c.(832-834)ttC>ttT	p.F278F	NLRP1_ENST00000572272.1_Silent_p.F278F|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000269280.4_Silent_p.F278F|NLRP1_ENST00000354411.3_Silent_p.F278F|NLRP1_ENST00000577119.1_Silent_p.F278F|NLRP1_ENST00000262467.5_Silent_p.F278F	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	278					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GCAGCTGTGTGAATTTTTGGT	0.502000													31	216					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92102787	92102787	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:92102787C>T	ENST00000256343.3	-	17	1880	c.1724G>A	c.(1723-1725)gGa>gAa	p.G575E		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	575					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TATCACTTTTCCATAGTGTAT	0.368000													12	114					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249636	52249636	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:52249636G>A	ENST00000595042.1	-	3	753	c.612C>T	c.(610-612)atC>atT	p.I204I	FPR1_ENST00000304748.4_Silent_p.I204I	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	204					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	TGATGAACCGGATGATGCCTC	0.512000													22	72					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43477637	43477637	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:43477637G>A	ENST00000395891.1	+	9	1442	c.837G>A	c.(835-837)ctG>ctA	p.L279L	HECW1_ENST00000453890.1_Silent_p.L279L|HECW1_ENST00000471043.1_3'UTR	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	279	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CTGACGTGCTGGAAATTGAGG	0.498000													18	107					0	0	1	0	0
PPTC7	160760	broad.mit.edu	37	12	110989647	110989647	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:110989647C>A	ENST00000354300.3	-	2	638	c.350G>T	c.(349-351)gGa>gTa	p.G117V		NM_139283.1	NP_644812.1	Q8NI37	PPTC7_HUMAN	PTC7 protein phosphatase homolog (S. cerevisiae)	117	PP2C-like.						metal ion binding|phosphoprotein phosphatase activity			endometrium(1)|large_intestine(2)|lung(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	9						GGTGAGAATTCCAATGGGATT	0.428000													39	166					6.2361e-21	6.36712e-21	1	1	0
DMRT3	58524	broad.mit.edu	37	9	990217	990217	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:990217G>A	ENST00000190165.2	+	2	669	c.631G>A	c.(631-633)Gga>Aga	p.G211R		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	211					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		CCAGAAAAACGGAGGCAACCC	0.602000													11	62					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40642347	40642347	+	Silent	SNP	G	G	A	rs7282000	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:40642347G>A	ENST00000342449.3	-	14	1335	c.1257C>T	c.(1255-1257)tcC>tcT	p.S419S	BRWD1_ENST00000333229.2_Silent_p.S419S|BRWD1_ENST00000380800.3_Silent_p.S419S	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TTTCCTCTTCGGAAGATAAGT	0.323000													3	11					0	0	1	0	0
PPP1R15A	23645	broad.mit.edu	37	19	49377075	49377075	+	Silent	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49377075T>C	ENST00000200453.5	+	2	854	c.585T>C	c.(583-585)gaT>gaC	p.D195D		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	195	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		AGGAGGACGATGAAGAAGCTG	0.532000													7	66					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124064440	124064440	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:124064440G>C	ENST00000373823.3	+	10	1096	c.191G>C	c.(190-192)tGg>tCg	p.W64S	GSN_ENST00000341272.2_Missense_Mutation_p.W64S|GSN_ENST00000373818.4_Missense_Mutation_p.W115S|GSN_ENST00000436847.1_Missense_Mutation_p.W75S|GSN_ENST00000373808.2_Missense_Mutation_p.W64S|GSN_ENST00000394353.2_Missense_Mutation_p.W75S|GSN_ENST00000412819.1_Missense_Mutation_p.W64S|GSN_ENST00000449733.1_Missense_Mutation_p.W64S|GSN_ENST00000545652.1_Missense_Mutation_p.W72S			P06396	GELS_HUMAN	gelsolin	115	Actin-severing (Potential).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						CTCCACTACTGGCTGGGTGAG	0.587000													9	59					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2716177	2716177	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:2716177G>A	ENST00000399655.1	+	26	3502	c.3237G>A	c.(3235-3237)ggG>ggA	p.G1079G	CACNA1C_ENST00000480911.1_Silent_p.G1079G|CACNA1C_ENST00000399634.1_Silent_p.G1079G|CACNA1C_ENST00000399644.1_Silent_p.G1079G|CACNA1C_ENST00000399591.1_Silent_p.G1079G|CACNA1C_ENST00000399597.1_Silent_p.G1079G|CACNA1C_ENST00000347598.4_Silent_p.G1099G|CACNA1C_ENST00000399629.1_Silent_p.G1079G|CACNA1C_ENST00000344100.3_Silent_p.G1079G|CACNA1C-AS3_ENST00000543559.1_RNA|CACNA1C_ENST00000399641.1_Silent_p.G1079G|CACNA1C_ENST00000399649.1_Silent_p.G1079G|CACNA1C_ENST00000402845.3_Silent_p.G1079G|CACNA1C_ENST00000399603.1_Silent_p.G1079G|CACNA1C_ENST00000399621.1_Silent_p.G1079G|CACNA1C_ENST00000399617.1_Silent_p.G1079G|CACNA1C_ENST00000327702.7_Silent_p.G1079G|CACNA1C_ENST00000335762.5_Silent_p.G1104G|CACNA1C_ENST00000399638.1_Silent_p.G1079G|CACNA1C_ENST00000399601.1_Silent_p.G1079G|CACNA1C_ENST00000399637.1_Silent_p.G1079G|CACNA1C_ENST00000399595.1_Silent_p.G1079G|CACNA1C_ENST00000406454.3_Silent_p.G1079G|CACNA1C_ENST00000399606.1_Silent_p.G1099G	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1099					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACAAAGACGGGGAGGTTGACC	0.552000													4	24					0	0	1	0	0
MBOAT7	79143	broad.mit.edu	37	19	54677874	54677874	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:54677874G>A	ENST00000245615.1	-	8	1763	c.1283C>T	c.(1282-1284)tCc>tTc	p.S428F	MBOAT7_ENST00000431666.2_Missense_Mutation_p.S355F|MBOAT7_ENST00000338624.6_Missense_Mutation_p.S355F	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	428					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GAAGTAGATGGAGGCCCAGTA	0.642000													11	73					0	0	1	0	0
BMPR1A	657	broad.mit.edu	37	10	88672037	88672037	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:88672037C>T	ENST00000372037.2	+	8	1108	c.571C>T	c.(571-573)Cgt>Tgt	p.R191C		NM_004329.2	NP_004320.2	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	191					BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|skin(1)|stomach(1)	24						TCGTTACAATCGTGATTTGGA	0.353000			"""Mis, N, F"""			gastrointestinal polyps			Juvenile Polyposis;Hereditary Mixed Polyposis syndrome type 2				8	63					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10366918	10366918	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:10366918C>T	ENST00000255381.2	-	8	801	c.691G>A	c.(691-693)Gaa>Aaa	p.E231K	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	231	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CCGAAGGCTTCCAGTAGGGGG	0.413000													7	70					0	0	1	0	0
ZNF311	282890	broad.mit.edu	37	6	28967304	28967304	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:28967304C>T	ENST00000377179.3	-	5	782	c.270G>A	c.(268-270)aaG>aaA	p.K90K	ZNF311_ENST00000483450.1_5'UTR	NM_001010877.2	NP_001010877.2	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(2)	28						ACATCACATCCTTATAGAGAT	0.383000													25	90					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43258631	43258631	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:43258631C>T	ENST00000404209.4	-	5	1193	c.1097G>A	c.(1096-1098)tGg>tAg	p.W366*	PSG8_ENST00000401467.2_Nonsense_Mutation_p.W273*|PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000306511.4_Nonsense_Mutation_p.W366*|PSG8_ENST00000406636.3_Nonsense_Mutation_p.W244*	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	366	Ig-like C2-type 3.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				ATTAATTGTCCAAGAATACTG	0.458000													57	344					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9033650	9033650	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:9033650G>A	ENST00000397910.4	-	9	36490	c.36287C>T	c.(36286-36288)tCc>tTc	p.S12096F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12098	SEA 1.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAACTTCCTGGAACCAGGGTG	0.587000													9	70					0	0	1	0	0
APOA2	336	broad.mit.edu	37	1	161192228	161192228	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:161192228G>A	ENST00000594609.1	+	2	163	c.163G>A	c.(163-165)Gaa>Aaa	p.E55K	APOA2_ENST00000367990.3_Silent_p.F90F|APOA2_ENST00000481413.1_5'UTR																							CAAGTTCCACGAAATAGCTCA	0.522000													48	156					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	167760167	167760167	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:167760167C>T	ENST00000409195.1	+	2	264	c.175C>T	c.(175-177)Ccc>Tcc	p.P59S	XIRP2_ENST00000295237.9_Missense_Mutation_p.P59S|XIRP2_ENST00000409043.1_Missense_Mutation_p.P59S|XIRP2_ENST00000409728.1_Missense_Mutation_p.P59S|XIRP2_ENST00000409756.2_Missense_Mutation_p.P59S|XIRP2_ENST00000420519.1_Missense_Mutation_p.P59S	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATCTTTGGATCCCACAAGTCT	0.498000													14	46					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8587370	8587370	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:8587370G>A	ENST00000338257.8	-	27	3378	c.3111C>T	c.(3109-3111)ccC>ccT	p.P1037P		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	1037						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						TCCGAGGCTGGGGCTTGGGTC	0.632000													3	18					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143135	55143135	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:55143135C>T	ENST00000396331.1	+	5	612	c.255C>T	c.(253-255)atC>atT	p.I85I	LILRB1_ENST00000396317.1_Silent_p.I85I|LILRB1_ENST00000448689.1_Silent_p.I85I|LILRB1_ENST00000418536.2_Silent_p.I85I|LILRB1_ENST00000396327.3_Silent_p.I85I|LILRB1_ENST00000396315.1_Silent_p.I85I|LILRB1_ENST00000434867.2_Silent_p.I85I|LILRB1_ENST00000396321.2_Silent_p.I85I|LILRB1_ENST00000427581.2_Silent_p.I121I|LILRB1_ENST00000324602.7_Silent_p.I85I|LILRB1_ENST00000396332.4_Silent_p.I85I	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	85	Ig-like C2-type 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		AGTTCCCCATCCCATCCATCA	0.557000										HNSCC(37;0.09)			20	102					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	703431	703431	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:703431T>C	ENST00000549091.1	+	11	1305	c.1213T>C	c.(1213-1215)Ttc>Ctc	p.F405L	WDR90_ENST00000293879.4_Missense_Mutation_p.F405L	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	405										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GCAGCGCTTCTTCCTTGGCCA	0.677000													10	43					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2888335	2888335	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:2888335G>A	ENST00000254695.8	+	11	878	c.788G>A	c.(787-789)gGa>gAa	p.G263E	RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.G263E|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.G248E|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.G244E	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	263	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						TTCAAATTCGGAGTCATTTAT	0.413000													23	185					0	0	1	0	0
PRDM10	56980	broad.mit.edu	37	11	129772231	129772231	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:129772231C>T	ENST00000358825.5	-	22	3691	c.3460G>A	c.(3460-3462)Gaa>Aaa	p.E1154K	PRDM10_ENST00000528746.1_Missense_Mutation_p.E1111K|PRDM10_ENST00000360871.3_Missense_Mutation_p.E1150K|PRDM10_ENST00000304538.6_Missense_Mutation_p.E1017K|PRDM10_ENST00000526082.1_Missense_Mutation_p.E1068K|PRDM10_ENST00000423662.2_Missense_Mutation_p.E1055K	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	1141					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E1150K(1)		breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		ATATGCACTTCGCTGCTTCCG	0.542000													29	97					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44071655	44071655	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:44071655G>A	ENST00000272286.2	+	2	163	c.73G>A	c.(73-75)Gat>Aat	p.D25N		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	25					cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GGGCCTCCAGGATAGATTGTT	0.522000													5	20					0	0	1	0	0
ESYT3	83850	broad.mit.edu	37	3	138187013	138187013	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:138187013A>C	ENST00000389567.4	+	12	1471	c.1285A>C	c.(1285-1287)Act>Cct	p.T429P		NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	429						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						TTCATTGCTTACTGACCAAGA	0.577000													7	39					0	0	1	0	0
PRCP	5547	broad.mit.edu	37	11	82560193	82560193	+	Silent	SNP	T	T	C	rs148080484	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:82560193T>C	ENST00000313010.3	-	6	1013	c.819A>G	c.(817-819)caA>caG	p.Q273Q	PRCP_ENST00000535099.1_Silent_p.Q168Q|PRCP_ENST00000393399.2_Silent_p.Q294Q	NM_005040.2	NP_005031.1	P42785	PCP_HUMAN	prolylcarboxypeptidase (angiotensinase C)	273	SKS domain.				blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						CTTTCAAATGTTGGATGTCCT	0.453000													21	92					0	0	1	0	0
PIK3R6	146850	broad.mit.edu	37	17	8739874	8739874	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:8739874A>G	ENST00000311434.9	-	7	690	c.451T>C	c.(451-453)Tac>Cac	p.Y151H	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	151					platelet activation	cytosol											CTCTCCTGGTAGGGATACAGC	0.517000													6	37					0	0	1	0	0
PLG	5340	broad.mit.edu	37	6	161160173	161160173	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:161160173G>A	ENST00000308192.9	+	16	2014	c.1951G>A	c.(1951-1953)Gaa>Aaa	p.E651K		NM_000301.3	NP_000292.1	P00747	PLMN_HUMAN	plasminogen	651	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)	59				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GCATGTTCAGGAAATAGAAGT	0.498000													23	103					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003126	122003126	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:122003126C>T	ENST00000498619.1	+	7	2793	c.2355C>T	c.(2353-2355)ttC>ttT	p.F785F	CASR_ENST00000490131.1_Silent_p.F775F|CASR_ENST00000296154.5_Silent_p.F775F	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	775					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCCTGGGCTTCCTGATCGGCT	0.587000													8	38					0	0	1	0	0
INPP5F	22876	broad.mit.edu	37	10	121551084	121551084	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:121551084C>T	ENST00000361976.2	+	4	537	c.371C>T	c.(370-372)cCt>cTt	p.P124L	INPP5F_ENST00000369083.3_Missense_Mutation_p.P124L|INPP5F_ENST00000369081.1_Missense_Mutation_p.P28L	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	124							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		ATACCATCTCCTGATGACTCA	0.323000													7	84					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39880254	39880254	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:39880254G>A	ENST00000260356.5	+	9	1471	c.1306G>A	c.(1306-1308)Ggt>Agt	p.G436S		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	436	TSP type-1 2.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TAAACAGGATGGTGGCTGGAG	0.507000													13	92					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24487988	24487988	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:24487988C>T	ENST00000264463.4	-	12	2658	c.2151G>A	c.(2149-2151)agG>agA	p.R717R	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	717					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GCTCTTTTAGCCTTTCATTAA	0.458000										HNSCC(23;0.051)			21	98					0	0	1	0	0
HEY2	23493	broad.mit.edu	37	6	126080376	126080376	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:126080376C>T	ENST00000368364.3	+	5	639	c.442C>T	c.(442-444)Ccg>Tcg	p.P148S	HEY2_ENST00000368365.1_Missense_Mutation_p.P102S	NM_012259.2	NP_036391.1	Q9UBP5	HEY2_HUMAN	hes-related family bHLH transcription factor with YRPW motif 2	148	Orange.				negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)|large_intestine(7)|lung(5)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		CTCCTCGGATCCGCTGCGGGT	0.617000													8	64					0	0	1	0	0
HPGDS	27306	broad.mit.edu	37	4	95220697	95220697	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:95220697C>T	ENST00000295256.5	-	6	624	c.534G>A	c.(532-534)cgG>cgA	p.R178R		NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	178	GST C-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	GGACTTTCTTCCGTAAAGTCA	0.468000													19	54					0	0	1	0	0
METTL13	51603	broad.mit.edu	37	1	171755035	171755035	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:171755035G>A	ENST00000361735.3	+	3	1196	c.930G>A	c.(928-930)gaG>gaA	p.E310E	METTL13_ENST00000362019.3_Silent_p.E224E|METTL13_ENST00000458517.1_Silent_p.E309E|METTL13_ENST00000367737.5_Silent_p.E154E	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	310							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						AGGGCCGGGAGACCGAGTGGC	0.572000													12	21					0	0	1	0	0
AREG	374	broad.mit.edu	37	4	75312380	75312380	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:75312380C>T	ENST00000395748.3	+	2	403	c.191C>T	c.(190-192)tCc>tTc	p.S64F	AREG_ENST00000502307.1_Missense_Mutation_p.S64F|AREG_ENST00000264487.2_Missense_Mutation_p.S64F	NM_001657.2	NP_001648.1	P15514	AREG_HUMAN	amphiregulin	64					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity			lung(4)	4			Lung(101;0.196)			AGTGAGATTTCCCCTGTGAGT	0.473000													15	105					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88768279	88768279	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:88768279C>T	ENST00000444431.1	+	0	2879				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										TGGGCTGGTCCAACCTGTTTA	0.557000													39	252					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46564805	46564805	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:46564805G>A	ENST00000458649.2	-	7	1180	c.762C>T	c.(760-762)atC>atT	p.I254I	AMBRA1_ENST00000314845.3_Silent_p.I254I|AMBRA1_ENST00000533727.1_Silent_p.I254I|AMBRA1_ENST00000298834.3_Silent_p.I254I|AMBRA1_ENST00000426438.1_Silent_p.I254I|AMBRA1_ENST00000528950.1_Silent_p.I254I|AMBRA1_ENST00000534300.1_Silent_p.I254I			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	254					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		CTCCCACCTGGATGCCAGAAG	0.632000													6	32					0	0	1	0	0
ANP32A	8125	broad.mit.edu	37	15	69113056	69113056	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:69113056C>T	ENST00000465139.2	-	1	178	c.35G>A	c.(34-36)cGg>cAg	p.R12Q	ANP32A_ENST00000560303.1_Missense_Mutation_p.R12Q|SPESP1_ENST00000560188.1_Intron	NM_006305.3	NP_006296.1	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	12					intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding			endometrium(1)|large_intestine(1)|lung(2)	4						CGTCCTGTTCCGCAGCTCTAA	0.557000													11	46					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98082469	98082469	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:98082469G>A	ENST00000419175.1	+	5	904	c.734G>A	c.(733-735)cGa>cAa	p.R245Q	DNTT_ENST00000371174.2_Missense_Mutation_p.R245Q	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	245	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		AATGATGAACGATATCAATCC	0.284000													11	73					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108487265	108487265	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:108487265G>A	ENST00000408999.3	+	20	2882	c.2805G>A	c.(2803-2805)aaG>aaA	p.K935K	RGPD4_ENST00000354986.4_Silent_p.K935K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	935					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						ATCAAGAAAAGGAAAGTGAAA	0.408000													56	368					0	0	1	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1628944	1628944	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:1628944G>A	ENST00000399685.1	-	1	749	c.672C>T	c.(670-672)tcC>tcT	p.S224S		NM_001012708.2	NP_001012726.1	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	224	11 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	8		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		AGCTGGACTGGGAGGAGCAGG	0.597000													12	201					0	0	1	0	0
MPZL2	10205	broad.mit.edu	37	11	118133683	118133683	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:118133683C>T	ENST00000278937.2	-	2	316	c.188G>A	c.(187-189)tGg>tAg	p.W63*	MPZL2_ENST00000438295.2_Nonsense_Mutation_p.W63*|MPZL2_ENST00000525647.1_5'UTR	NM_005797.3	NP_005788.1	O60487	MPZL2_HUMAN	myelin protein zero-like 2	63	Ig-like V-type.				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|skin(1)	11	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		ACGAAAATTCCAGGTCACTGT	0.468000													23	174					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210334122	210334122	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:210334122C>T	ENST00000537238.1	+	9	1680	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F	SYT14_ENST00000367015.1_Missense_Mutation_p.S430F|SYT14_ENST00000534859.1_Missense_Mutation_p.S494F|SYT14_ENST00000422431.1_Missense_Mutation_p.S532F|SYT14_ENST00000472886.1_Missense_Mutation_p.S468F|SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000399639.2_3'UTR|SYT14_ENST00000367019.1_Missense_Mutation_p.S487F	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	468	C2 2.					integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		CAAGAGATGTCCAAATGCAAG	0.373000													10	68					0	0	1	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	553031	553031	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:553031C>T	ENST00000262305.4	+	7	1717	c.1329C>T	c.(1327-1329)acC>acT	p.T443T	RAB11FIP3_ENST00000457159.1_Silent_p.T488T|RAB11FIP3_ENST00000450428.1_Silent_p.T147T	NM_014700.3	NP_055515.1	O75154	RFIP3_HUMAN	RAB11 family interacting protein 3 (class II)	443					cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				GGGCCCTGACCATGGAGGCCC	0.592000													9	57					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70503813	70503813	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:70503813C>T	ENST00000310961.5	+	22	2625	c.2207C>T	c.(2206-2208)cCa>cTa	p.P736L	LRRC7_ENST00000035383.5_Missense_Mutation_p.P731L|LRRC7_ENST00000415775.2_Missense_Mutation_p.P15L			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	731						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCATCTTTCCCACAGCCTCTT	0.507000													37	250					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	88365929	88365929	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:88365929C>T	ENST00000518476.1	+	10	1269	c.1218C>T	c.(1216-1218)agC>agT	p.S406S		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	406								p.S406S(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						GTGAGATTAGCGTCCTTCTTC	0.323000													12	60					0	0	1	0	0
OR51A2	401667	broad.mit.edu	37	11	4976383	4976383	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:4976383C>T	ENST00000380371.1	-	1	560	c.561G>A	c.(559-561)atG>atA	p.M187I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004748.1	NP_001004748.1	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A, member 2	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGCCAACTTCATGACATCCT	0.423000													18	40					0	0	1	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119938736	119938736	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:119938736G>A	ENST00000297350.4	-	4	1192	c.814C>T	c.(814-816)Caa>Taa	p.Q272*		NM_002546.3	NP_002537.3	O00300	TR11B_HUMAN	tumor necrosis factor receptor superfamily, member 11b	272	Death 2.				apoptosis|skeletal system development		cytokine activity|receptor activity			breast(1)|central_nervous_system(3)|endometrium(4)|large_intestine(6)|lung(7)|prostate(3)|skin(1)	25	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			ATCATACCTTGGATGATCTTC	0.353000													7	87					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175332856	175332856	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:175332856G>A	ENST00000367674.1	-	13	3403	c.2695C>T	c.(2695-2697)Cga>Tga	p.R899*	TNR_ENST00000263525.2_Nonsense_Mutation_p.R899*	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	899	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix		p.R899*(1)		NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TGGGTGGGTCGATATGATACT	0.448000													35	91					0	0	1	0	0
A1BG	1	broad.mit.edu	37	19	58862778	58862778	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:58862778C>T	ENST00000263100.3	-	5	950	c.889G>A	c.(889-891)Gtc>Atc	p.V297I	A1BG-AS1_ENST00000593374.1_RNA|A1BG-AS1_ENST00000600686.1_RNA|A1BG-AS1_ENST00000593960.1_RNA|A1BG-AS1_ENST00000600379.1_RNA|A1BG-AS1_ENST00000599728.1_RNA|A1BG-AS1_ENST00000594950.1_RNA|CTD-2619J13.8_ENST00000599109.1_RNA	NM_130786.3	NP_570602.2	P04217	A1BG_HUMAN	alpha-1-B glycoprotein	297	Ig-like V-type 3.					extracellular region				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|prostate(2)	15		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		ATCAGCTCGACCGGCGCGCTG	0.662000													11	85					0	0	1	0	0
COPZ2	51226	broad.mit.edu	37	17	46110610	46110610	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:46110610G>A	ENST00000006101.4	-	5	320	c.321C>T	c.(319-321)ttC>ttT	p.F107F	COPZ2_ENST00000584666.1_5'UTR	NM_016429.2	NP_057513.1	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	109					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat				lung(3)|upper_aerodigestive_tract(1)	4						CCACGTATAGGAAGAGGTCAA	0.488000													3	21					0	0	1	0	0
LRRC46	90506	broad.mit.edu	37	17	45913839	45913839	+	Missense_Mutation	SNP	G	G	A	rs144936742	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:45913839G>A	ENST00000269025.4	+	7	956	c.593G>A	c.(592-594)cGa>cAa	p.R198Q		NM_033413.3	NP_219481.1	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	198										endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)	9						TGCTCAGAACGAGGTGACCCT	0.612000													6	33					0	0	1	0	0
SLTM	79811	broad.mit.edu	37	15	59179248	59179248	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:59179248G>A	ENST00000380516.2	-	19	2848	c.2761C>T	c.(2761-2763)Cgt>Tgt	p.R921C	SLTM_ENST00000536328.1_Missense_Mutation_p.R490C	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	921					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GCGCTGCTACGATTCCCAGGG	0.547000													15	53					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219513367	219513367	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:219513367G>A	ENST00000411696.2	-	5	2043	c.1264C>T	c.(1264-1266)Cta>Tta	p.L422L	ZNF142_ENST00000449707.1_Silent_p.L422L			P52746	ZN142_HUMAN	zinc finger protein 142	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		cccgtatgtagaagcatgtgt	0.448000											OREG0015202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	33					0	0	1	0	0
ZNF98	148198	broad.mit.edu	37	19	22586194	22586194	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:22586194A>G	ENST00000357774.5	-	2	272	c.151T>C	c.(151-153)Ttt>Ctt	p.F51L	ZNF98_ENST00000601553.1_Missense_Mutation_p.F51L	NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	51	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TCACCCACAAAGACCAGGTTT	0.368000													7	124					0	0	1	0	0
PTP4A2	8073	broad.mit.edu	37	1	32377409	32377409	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:32377409C>T	ENST00000344035.6	-	4	1201	c.208G>A	c.(208-210)Gga>Aga	p.G70R	PTP4A2_ENST00000356536.3_Intron|RP11-84A19.4_ENST00000602889.1_lincRNA|PTP4A2_ENST00000602725.1_Missense_Mutation_p.G70R|PTP4A2_ENST00000470404.1_Intron|PTP4A2_ENST00000457805.2_Missense_Mutation_p.G39R	NM_080391.3	NP_536316.1	Q12974	TP4A2_HUMAN	protein tyrosine phosphatase type IVA, member 2	70						early endosome|plasma membrane	prenylated protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity			kidney(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)				GGTGGAGCTCCATCATCAAAT	0.383000													7	76					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101323690	101323690	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:101323690C>T	ENST00000344327.3	-	13	3216	c.2792G>A	c.(2791-2793)aGa>aAa	p.R931K	TRPC6_ENST00000348423.4_Missense_Mutation_p.R815K|TRPC6_ENST00000532133.1_Missense_Mutation_p.R853K|TRPC6_ENST00000360497.4_Missense_Mutation_p.R876K	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	931					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TTCGCATTATCTATTGGTTTC	0.343000													14	111					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26917366	26917366	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:26917366C>T	ENST00000539517.2	-	5	1640	c.1323G>A	c.(1321-1323)ggG>ggA	p.G441G	NOVA1_ENST00000465357.2_Silent_p.G417G|NOVA1_ENST00000267422.7_Silent_p.G319G	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	444	KH 3.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		CTAATGTTTTCCCTCCTTTGC	0.433000													6	39					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46812068	46812068	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:46812068C>T	ENST00000529230.1	-	14	1762	c.1716G>A	c.(1714-1716)aaG>aaA	p.K572K	CKAP5_ENST00000312055.5_Silent_p.K572K|CKAP5_ENST00000354558.3_Silent_p.K572K|CKAP5_ENST00000415402.1_Silent_p.K572K			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	572					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						CTTTCTTGTTCTTGGTTCCAG	0.448000													18	76					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832293	61832293	+	Silent	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:61832293T>C	ENST00000280772.1	-	37	8537	c.8346A>G	c.(8344-8346)aaA>aaG	p.K2782K	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2782					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CCATAAAATCTTTTTGCACAG	0.373000													18	85					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284169	152284169	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:152284169C>T	ENST00000368799.1	-	3	3228	c.3193G>A	c.(3193-3195)Ggg>Agg	p.G1065R	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1065	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACTGGACCCCCAGTGTCCA	0.577000									Ichthyosis				109	774					0	0	1	0	0
TCTN1	79600	broad.mit.edu	37	12	111085661	111085661	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:111085661C>T	ENST00000551590.1	+	14	1884	c.1728C>T	c.(1726-1728)gcC>gcT	p.A576A	TCTN1_ENST00000397655.3_Silent_p.A562A|HVCN1_ENST00000548312.1_Intron|TCTN1_ENST00000397659.4_Silent_p.A581A|TCTN1_ENST00000377654.3_3'UTR			Q2MV58	TECT1_HUMAN	tectonic family member 1	576					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						CCATCAATGCCAGGCTGCCCT	0.517000													15	65					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322730	79322730	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:79322730C>T	ENST00000428286.1	-	8	4583	c.3383G>A	c.(3382-3384)cGa>cAa	p.R1128Q	PRUNE2_ENST00000376718.3_Missense_Mutation_p.R1487Q			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1487					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						ATCAAGACTTCGGGGAACTCT	0.438000													6	25					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129951961	129951961	+	Splice_Site	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:129951961C>T	ENST00000222482.4	+	10	1105	c.1078_splice	c.e10+1	p.V359_splice	CPA4_ENST00000445470.2_Splice_Site_p.V326_splice|CPA4_ENST00000493259.1_Splice_Site_p.V255_splice	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	359					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					GCACCACTGTCTGTAAGTACT	0.502000													6	44					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93026961	93026961	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:93026961G>A	ENST00000523629.1	-	4	768	c.314C>T	c.(313-315)tCc>tTc	p.S105F	RUNX1T1_ENST00000520724.1_Missense_Mutation_p.S68F|RUNX1T1_ENST00000422361.2_Missense_Mutation_p.S68F|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.S78F|RUNX1T1_ENST00000521553.1_Missense_Mutation_p.S68F|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.S78F|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.S68F|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.S105F|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.S116F	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	105	Poly-Ser.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			AGAGGAGGAGGAAGAAGAGGA	0.547000													13	74					0	0	1	0	0
AFP	174	broad.mit.edu	37	4	74309129	74309129	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:74309129G>A	ENST00000395792.2	+	6	781	c.681G>A	c.(679-681)atG>atA	p.M227I	AFP_ENST00000226359.2_Missense_Mutation_p.M227I	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	227	Albumin 2.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTGCAGTAATGAAAAATTTTG	0.388000									Alpha-Fetoprotein, Hereditary Persistence of				12	61					0	0	1	0	0
C11orf24	53838	broad.mit.edu	37	11	68029170	68029170	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:68029170C>T	ENST00000304271.6	-	4	1695	c.1293G>A	c.(1291-1293)aaG>aaA	p.K431K	C11orf24_ENST00000533310.1_Silent_p.K96K	NM_022338.3	NP_071733.1	Q96F05	CK024_HUMAN	chromosome 11 open reading frame 24	431						integral to membrane				endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)	13						GGGTGTAGTCCTTCTTCTTGT	0.557000													21	71					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270284	1270284	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:1270284C>T	ENST00000348261.5	+	35	6600	c.6352C>T	c.(6352-6354)Cat>Tat	p.H2118Y	CACNA1H_ENST00000565831.1_Missense_Mutation_p.H2112Y|CACNA1H_ENST00000358590.4_Missense_Mutation_p.H2112Y	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2118					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGCCGAGCCCCATGGCCCCGA	0.736000													3	9					0	0	1	0	0
DHRS11	79154	broad.mit.edu	37	17	34951505	34951505	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:34951505C>T	ENST00000251312.5	+	2	464	c.252C>T	c.(250-252)atC>atT	p.I84I	DHRS11_ENST00000394445.1_3'UTR|DHRS11_ENST00000590554.1_Silent_p.I5I	NM_024308.3	NP_077284.2	Q6UWP2	DHR11_HUMAN	dehydrogenase/reductase (SDR family) member 11	84						extracellular region	binding|oxidoreductase activity			endometrium(1)|lung(4)	5						TCTCAGCTATCCGTTCTCAGC	0.537000													26	81					0	0	1	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1628945	1628945	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:1628945G>A	ENST00000399685.1	-	1	748	c.671C>T	c.(670-672)tCc>tTc	p.S224F		NM_001012708.2	NP_001012726.1	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	224	11 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	8		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		GCTGGACTGGGAGGAGCAGGG	0.597000													14	202					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846494	47846494	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:47846494C>T	ENST00000339488.4	-	3	2119	c.2086G>A	c.(2086-2088)Gag>Aag	p.E696K		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	696						integral to membrane	hedgehog receptor activity										ACGCCCAGCTCAATTGAGGTG	0.453000													11	30					0	0	1	0	0
PKP3	11187	broad.mit.edu	37	11	404551	404551	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:404551G>A	ENST00000331563.2	+	13	2452	c.2376G>A	c.(2374-2376)gaG>gaA	p.E792E		NM_007183.2	NP_009114.1	Q9Y446	PKP3_HUMAN	plakophilin 3	792					cell adhesion	desmosome|nucleus	binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATCGGAAGGAGGACTTCCTGG	0.632000													6	33					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25420014	25420014	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:25420014C>T	ENST00000549301.1	+	0	749				SNHG14_ENST00000441592.2_RNA																							TCCACTGAGCCTTGGTGAGCC	0.532000													49	199					0	0	1	0	0
RSPH3	83861	broad.mit.edu	37	6	159420872	159420872	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:159420872C>T	ENST00000252655.1	-	1	326	c.137G>A	c.(136-138)gGg>gAg	p.G46E	RSPH3_ENST00000297262.3_Missense_Mutation_p.G46E|RSPH3_ENST00000367069.2_5'UTR|RP1-111C20.4_ENST00000607391.1_RNA	NM_031924.4	NP_114130.3	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog (Chlamydomonas)	46										endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|skin(1)|stomach(7)	23		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		GTTCCGGTCCCCAGGTTTCCC	0.687000													8	48					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532751	84532751	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:84532751C>T	ENST00000527857.1	+	0	2773					NR_026851.1																						TTAAAACTTTCCGTATGAGGA	0.433000													5	30					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125094565	125094565	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr8:125094565C>T	ENST00000522917.1	+	33	4463	c.4257C>T	c.(4255-4257)tcC>tcT	p.S1419S	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Silent_p.S1419S	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1419	C2 5.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CAAAAGAGTCCCTGCTCTCCA	0.488000													26	152					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51929785	51929785	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:51929785C>T	ENST00000371117.3	-	13	1219	c.944G>A	c.(943-945)gGa>gAa	p.G315E	PKHD1_ENST00000340994.4_Missense_Mutation_p.G315E	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	315	IPT/TIG 3.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CACATCTTTTCCTGGAGCCCG	0.463000													16	67					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21721855	21721855	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:21721855G>A	ENST00000261195.2	-	5	1021	c.767C>T	c.(766-768)aCc>aTc	p.T256I		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	256					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						AGAAACCGTGGTGAACACGTG	0.438000													21	121					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576797	158576797	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:158576797G>A	ENST00000361284.1	+	1	569	c.569G>A	c.(568-570)gGa>gAa	p.G190E		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					CTAGCCTGTGGAGATACAGGC	0.493000													49	124					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	33094022	33094022	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:33094022C>T	ENST00000375028.3	+	9	904	c.834C>T	c.(832-834)ttC>ttT	p.F278F	C10orf68_ENST00000375025.4_Silent_p.F338F|C10orf68_ENST00000375030.2_Intron			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	302										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						CAAAGAGTTTCCCTGGTAAGA	0.313000													24	148					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47788571	47788571	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:47788571C>T	ENST00000398545.4	-	2	205	c.88G>A	c.(88-90)Ggc>Agc	p.G30S		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	30										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GCTCCTTGGCCTTTAGGAGGC	0.398000													9	60					0	0	1	0	0
NBAS	51594	broad.mit.edu	37	2	15470728	15470728	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:15470728G>A	ENST00000281513.5	-	36	4366	c.4341C>T	c.(4339-4341)ccC>ccT	p.P1447P	NBAS_ENST00000441750.1_Silent_p.P1327P	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1447										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						TTACCTGAAGGGGTCGAAGGT	0.413000													6	36					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54530441	54530441	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:54530441C>T	ENST00000373968.3	-	2	357	c.293G>A	c.(292-294)gGa>gAa	p.G98E	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	98	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						CGGACTTTTTCCAGGGTCTCC	0.577000													19	117					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47221585	47221585	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:47221585C>T	ENST00000319190.5	+	7	1301	c.933C>T	c.(931-933)ttC>ttT	p.F311F	TTC7A_ENST00000263737.6_Intron|TTC7A_ENST00000394850.2_Silent_p.F311F|TTC7A_ENST00000409245.1_Silent_p.F277F|TTC7A_ENST00000461601.1_3'UTR	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	311							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGCCTGAGTTCATGGGCAAGG	0.612000													17	79					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6228297	6228297	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:6228297G>A	ENST00000262450.3	-	2	219	c.120C>T	c.(118-120)ttC>ttT	p.F40F	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	40					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GCTCCACAGGGAAAAAGTCAT	0.502000													40	214					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196722110	196722110	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:196722110G>A	ENST00000312428.6	-	44	8505	c.8405C>T	c.(8404-8406)tCa>tTa	p.S2802L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2802	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTTATCATATGAATCCATTGC	0.343000													11	81					0	0	1	0	0
AMBN	258	broad.mit.edu	37	4	71471905	71471905	+	Missense_Mutation	SNP	G	G	A	rs146167261	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:71471905G>A	ENST00000322937.6	+	13	905	c.802G>A	c.(802-804)Ggg>Agg	p.G268R	AMBN_ENST00000449493.2_Missense_Mutation_p.G253R	NM_016519.5	NP_057603.1	Q9NP70	AMBN_HUMAN	ameloblastin (enamel matrix protein)	268					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel	p.G268W(1)		NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)	29			Lung(101;0.235)			TTTCCAGGGCGGGAGAGAAGA	0.488000													17	62					0	0	1	0	0
KRTAP4-5	85289	broad.mit.edu	37	17	39305744	39305744	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:39305744C>T	ENST00000343246.4	-	1	310	c.276G>A	c.(274-276)agG>agA	p.R92R		NM_033188.3	NP_149445.3	Q9BYR2	KRA45_HUMAN	keratin associated protein 4-5	97	27 X 5 AA repeats of C-C-[GRQVCHIEK]- [SPTR]-[VSTQYC].					keratin filament				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			agcaggtggtcctgcagcagg	0.662000													5	39					0	0	1	0	0
IQCE	23288	broad.mit.edu	37	7	2638229	2638229	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:2638229G>A	ENST00000402050.2	+	17	1755	c.1571G>A	c.(1570-1572)aGa>aAa	p.R524K	IQCE_ENST00000404984.1_Missense_Mutation_p.R473K|IQCE_ENST00000325979.7_Missense_Mutation_p.R459K|IQCE_ENST00000438376.2_Missense_Mutation_p.R508K	NM_001100390.1|NM_152558.3	NP_001093860.1|NP_689771.3	Q6IPM2	IQCE_HUMAN	IQ motif containing E	524										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GCCGCGGCCAGAGTCCTGCAG	0.687000													11	54					0	0	1	0	0
PRPF4	9128	broad.mit.edu	37	9	116041300	116041300	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:116041300G>A	ENST00000374199.4	+	3	682	c.281G>A	c.(280-282)cGa>cAa	p.R94Q	PRPF4_ENST00000374198.4_Missense_Mutation_p.R95Q			O43172	PRP4_HUMAN	pre-mRNA processing factor 4	95				HISERQAEVLAEFERRKRARQINVST -> ISASDRQKYWL SLREGSEPGRSMFPP (in Ref. 3; AAC02261).		Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)	23						AGAAGGAAGCGAGCCCGGCAG	0.468000													15	90					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48389519	48389519	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:48389519C>T	ENST00000224600.4	-	1	1472	c.1359G>A	c.(1357-1359)ctG>ctA	p.L453L		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	453	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CCAACACACCCAGGACGGAGG	0.617000													6	34					0	0	1	0	0
FASTK	10922	broad.mit.edu	37	7	150776809	150776809	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:150776809G>A	ENST00000540185.1	-	2	785	c.181C>T	c.(181-183)Cct>Tct	p.P61S	FASTK_ENST00000482571.1_Missense_Mutation_p.P95S|FASTK_ENST00000489884.1_Intron|FASTK_ENST00000353841.2_Intron|FASTK_ENST00000297532.6_Missense_Mutation_p.P95S			Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase	95					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(4)|stomach(2)	6			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		AGCTCCCCAGGGCTCTTCGCC	0.677000													3	7					0	0	1	0	0
KIAA1328	57536	broad.mit.edu	37	18	34424175	34424175	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:34424175C>T	ENST00000591619.1	+	4	1016	c.230C>T	c.(229-231)tCc>tTc	p.S77F	KIAA1328_ENST00000280020.5_Missense_Mutation_p.S81F|KIAA1328_ENST00000543923.1_Intron|KIAA1328_ENST00000435985.2_5'UTR|KIAA1328_ENST00000592521.1_Missense_Mutation_p.S81F			Q86T90	K1328_HUMAN	KIAA1328	81										central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	14				COAD - Colon adenocarcinoma(74;0.195)		TTTAAGAATTCCTGCAGGGGA	0.308000													10	22					0	0	1	0	0
LMAN2	10960	broad.mit.edu	37	5	176764725	176764725	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:176764725G>A	ENST00000303127.7	-	4	699	c.495C>T	c.(493-495)ccC>ccT	p.P165P	LMAN2_ENST00000506310.1_5'UTR|LMAN2_ENST00000515209.1_Silent_p.P165P	NM_006816.2	NP_006807.1	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2	165	Carbohydrate binding (By similarity).|L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCATCATTGGGGTAGGTGT	0.537000													9	22					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546731	11546731	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:11546731G>A	ENST00000389362.4	-	3	316	c.281C>T	c.(280-282)cCt>cTt	p.P94L	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTTTCCTGGAGGTGGGGGACC	0.617000													75	461					0	0	1	0	0
CTSH	1512	broad.mit.edu	37	15	79231507	79231507	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:79231507A>G	ENST00000220166.5	-	2	207	c.98T>C	c.(97-99)tTt>tCt	p.F33S		NM_004390.3	NP_004381.2	P09668	CATH_HUMAN	cathepsin H	33					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)	10						CTTGAAGTGAAACTTCTCTGT	0.368000													6	38					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43918339	43918339	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:43918339G>A	ENST00000336086.6	-	4	2830	c.594C>T	c.(592-594)tcC>tcT	p.S198S	URGCP_ENST00000453200.1_Silent_p.S241S|URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000447717.3_Silent_p.S198S|URGCP_ENST00000223341.7_Silent_p.S198S|RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000402306.3_Silent_p.S232S|URGCP_ENST00000443736.1_Silent_p.S198S			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	241					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TTGGGGGCTGGGACCACCATG	0.612000													4	31					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36485665	36485665	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:36485665C>T	ENST00000342292.4	-	11	3807	c.3787G>A	c.(3787-3789)Gaa>Aaa	p.E1263K		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	1263						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GGGCAGATTTCGGCCTTGTTG	0.607000													23	58					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23937644	23937644	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:23937644C>T	ENST00000402377.3	-	3	348	c.207G>A	c.(205-207)agG>agA	p.R69R	ZNF681_ENST00000395385.3_5'UTR	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CGGCCACCATCCTATGTCTCT	0.408000													18	107					0	0	1	0	0
ATRIP	84126	broad.mit.edu	37	3	48506018	48506018	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:48506018C>T	ENST00000412052.1	+	11	2195	c.1733C>T	c.(1732-1734)cCc>cTc	p.P578L	ATRIP_ENST00000346691.4_Intron|ATRIP_ENST00000357105.6_Missense_Mutation_p.P544L|ATRIP_ENST00000320211.3_Missense_Mutation_p.P671L	NM_001271023.1	NP_001257952.1	Q8WXE1	ATRIP_HUMAN	ATR interacting protein	671					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)	22				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTGCAGAGCCCCTTGCCCCCA	0.602000								Other conserved DNA damage response genes					17	96					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52942551	52942551	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:52942551C>T	ENST00000267119.5	-	4	816	c.747G>A	c.(745-747)gtG>gtA	p.V249V		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	249	Coil 1B.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CCTGCAGTTCCACCTTATTGG	0.547000													15	94					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762860	130762860	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:130762860G>A	ENST00000392429.1	+	2	3671	c.1293G>A	c.(1291-1293)atG>atA	p.M431I	TMEM200A_ENST00000545622.1_Missense_Mutation_p.M431I|TMEM200A_ENST00000296978.3_Missense_Mutation_p.M431I	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	431						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		AGGGATATATGAAACTAGAGA	0.453000													17	84					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117664496	117664496	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:117664496G>A	ENST00000317775.6	-	24	4381	c.3696C>T	c.(3694-3696)ttC>ttT	p.F1232F	NOS1_ENST00000338101.4_Silent_p.F1266F|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1232	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding	p.F1232F(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ACCCTCTCACGAAACAGGGGA	0.488000													6	33					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5087375	5087375	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:5087375G>A	ENST00000399604.4	-	1	317	c.177C>T	c.(175-177)ctC>ctT	p.L59L	ZNF594_ENST00000575779.1_Silent_p.L59L			Q96JF6	ZN594_HUMAN	zinc finger protein 594	59					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CTTGGGAAGGGAGATGTCTCA	0.428000													13	107					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154625607	154625607	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:154625607G>A	ENST00000260010.6	+	1	2956	c.1548G>A	c.(1546-1548)aaG>aaA	p.K516K		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	516					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				CGTTTTCTAAGGAGCAACTTG	0.408000													14	77					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3261843	3261843	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:3261843G>A	ENST00000217939.6	-	2	186	c.32C>T	c.(31-33)tCc>tTc	p.S11F		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	11						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CAGCACCACGGAGAGGGCCCC	0.622000													6	7					0	0	1	0	0
CORO2A	7464	broad.mit.edu	37	9	100895494	100895494	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:100895494C>T	ENST00000343933.5	-	5	731	c.474G>A	c.(472-474)atG>atA	p.M158I	CORO2A_ENST00000375077.4_Missense_Mutation_p.M158I	NM_003389.3	NP_003380.3	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	158					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|skin(4)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				GGTTCCAGATCATCACCTGCA	0.532000													10	50					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587850	179587850	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:179587850C>T	ENST00000589042.1	-	75	22108	c.21884G>A	c.(21883-21885)aGa>aAa	p.R7295K	TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R6978K|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.R6051K|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6978	Ig-like 55.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTGCATCTCTTTTTGTGCT	0.383000													6	46					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47046037	47046037	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:47046037C>T	ENST00000450053.3	+	38	6430	c.6251C>T	c.(6250-6252)aCc>aTc	p.T2084I	NBEAL2_ENST00000383740.2_Missense_Mutation_p.T363I|NBEAL2_ENST00000292309.5_Missense_Mutation_p.T1900I	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2084	BEACH.						binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CAACTCAACACCATTGCGGGG	0.587000													9	47					0	0	1	0	0
LRCH2	57631	broad.mit.edu	37	X	114357726	114357726	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:114357726C>T	ENST00000317135.8	-	18	1909	c.1879G>A	c.(1879-1881)Ggg>Agg	p.G627R	LRCH2_ENST00000538422.1_Missense_Mutation_p.G610R	NM_020871.3	NP_065922.3	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 2	627										breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	19						TCTGCTGCCCCATATTCTTGG	0.418000													6	12					0	0	1	0	0
VAT1	10493	broad.mit.edu	37	17	41168114	41168114	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:41168114C>A	ENST00000355653.3	-	6	1241	c.1146G>T	c.(1144-1146)aaG>aaT	p.K382N	VAT1_ENST00000587173.1_Missense_Mutation_p.K314N|VAT1_ENST00000420567.3_Missense_Mutation_p.K248N	NM_006373.3	NP_006364.2	Q99536	VAT1_HUMAN	vesicle amine transport 1	382						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CCAGGAGGACCTTGCCCACAT	0.552000													94	337					4.09499e-44	4.19276e-44	1	1	0
OVCH1	341350	broad.mit.edu	37	12	29640714	29640714	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:29640714G>A	ENST00000318184.5	-	7	803	c.804C>T	c.(802-804)ccC>ccT	p.P268P		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	268	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					tgtttcttaCGGGAACTGAAC	0.468000													4	19					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	5605454	5605454	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrY:5605454G>A	ENST00000215473.6	+	6	3494	c.3494G>A	c.(3493-3495)tGc>tAc	p.C1165Y				Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	1165					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						TCTGCTCTATGCCACAGCCCA	0.552000													6	48					0	0	1	0	0
ENPP7	339221	broad.mit.edu	37	17	77708877	77708877	+	Silent	SNP	G	G	A	rs143305291		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:77708877G>A	ENST00000328313.5	+	3	656	c.435G>A	c.(433-435)ggG>ggA	p.G145G		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	145					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			ACCCGGGCGGGAACGTCACCT	0.597000													6	37					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29497997	29497997	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:29497997G>A	ENST00000389048.3	-	11	2915	c.2009C>T	c.(2008-2010)tCa>tTa	p.S670L	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	670					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CTGTCTTGGTGAATTTTCCCC	0.468000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				7	75					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55638953	55638953	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:55638953C>T	ENST00000370830.3	-	4	1619	c.921G>A	c.(919-921)gcG>gcA	p.A307A	BMP5_ENST00000446683.2_Silent_p.A307A	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	307					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GTACCTCACTCGCCTTGAAGA	0.468000													26	113					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48628143	48628143	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:48628143C>T	ENST00000006658.6	+	11	1368	c.1248C>T	c.(1246-1248)taC>taT	p.Y416Y	SPATA20_ENST00000511937.1_3'UTR|SPATA20_ENST00000393244.3_Silent_p.Y356Y|SPATA20_ENST00000356488.4_Silent_p.Y400Y	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	400					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			AGGGCGCCTACTATGTGTGGA	0.642000											OREG0024568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	112					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55652968	55652968	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:55652968T>C	ENST00000449290.2	+	2	156	c.64T>C	c.(64-66)Ttc>Ctc	p.F22L		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	22						intracellular	zinc ion binding										CATGAACTACTTCCTAGACCC	0.498000													17	95					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343343	248343343	+	Missense_Mutation	SNP	A	A	C	rs141475463	byFrequency	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:248343343A>C	ENST00000359682.2	+	1	56	c.56A>C	c.(55-57)aAt>aCt	p.N19T		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGAATCTTCAATCACAGCCCA	0.453000													37	366					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449164	104449164	+	Missense_Mutation	SNP	C	C	T	rs145326290	by1000genomes	TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:104449164C>T	ENST00000361820.3	-	2	1618	c.1018G>A	c.(1018-1020)Gaa>Aaa	p.E340K		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	340					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GTTGTAATTTCGAAAATCCGC	0.517000													7	38					0	0	1	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47123298	47123298	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:47123298G>A	ENST00000290341.3	+	13	1776	c.1442G>A	c.(1441-1443)gGt>gAt	p.G481D	IGF2BP1_ENST00000431824.2_Missense_Mutation_p.G342D	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	481	Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AACTTCTTTGGTCCCAAGGAG	0.498000													19	36					0	0	1	0	0
SARM1	23098	broad.mit.edu	37	17	26711525	26711525	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:26711525G>A	ENST00000457710.3	+	3	1608	c.1137G>A	c.(1135-1137)aaG>aaA	p.K379K	SARM1_ENST00000379061.4_3'UTR	NM_015077.2	NP_055892.2	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	413					innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity			cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CCAGCTGGAAGGAGGCCGAGG	0.657000													4	20					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49881982	49881982	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:49881982G>A	ENST00000331456.2	-	4	385	c.272C>T	c.(271-273)tCc>tTc	p.S91F	TRAIP_ENST00000469027.1_Intron|TRAIP_ENST00000473863.1_5'UTR	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	91					cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding	p.S91F(2)		breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACCTTTCTGGGAAAGCTGGGC	0.532000													5	29					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45947241	45947241	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:45947241G>A	ENST00000323084.4	-	7	1148	c.1083C>T	c.(1081-1083)ttC>ttT	p.F361F	TSPEAR_ENST00000397916.1_Silent_p.F293F	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	361					cell adhesion	extracellular region	structural molecule activity	p.F361F(2)		breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						GATATGAGACGAACTTCTCTT	0.552000													15	113					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42819408	42819408	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:42819408G>A	ENST00000598766.1	+	7	646	c.646G>A	c.(646-648)Gga>Aga	p.G216R	TMEM145_ENST00000301204.3_Missense_Mutation_p.G192R			Q8NBT3	TM145_HUMAN	transmembrane protein 145	192						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				ttGTTACTTTGGATGTGAGTC	0.537000													16	87					0	0	1	0	0
CERCAM	51148	broad.mit.edu	37	9	131191038	131191038	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:131191038G>T	ENST00000372842.1	+	8	3799	c.655G>T	c.(655-657)Gac>Tac	p.D219Y	CERCAM_ENST00000372838.4_Missense_Mutation_p.D297Y			Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule	297					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				endometrium(2)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|pancreas(2)	20						CTTTGCAGTGGACGGCCCCCG	0.617000													5	42					3.59834e-05	3.64332e-05	1	1	0
UGT2B10	7365	broad.mit.edu	37	4	69682406	69682406	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:69682406C>T	ENST00000265403.7	+	1	696	c.669C>T	c.(667-669)ttC>ttT	p.F223F	UGT2B10_ENST00000458688.2_Intron	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	223					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						ACTTTTGGTTCCAAATATTTA	0.303000													13	68					0	0	1	0	0
KRT16	3868	broad.mit.edu	37	17	39768609	39768609	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:39768609C>T	ENST00000301653.4	-	1	396	c.332G>A	c.(331-333)gGg>gAg	p.G111E		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	111	Head.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				CACCAGAAGCccatcaccacc	0.607000													14	97					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66946334	66946334	+	Splice_Site	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:66946334C>T	ENST00000299752.4	-	12	1553		c.e12-1		CDH16_ENST00000394055.3_Splice_Site|CDH16_ENST00000570262.1_Splice_Site|CDH16_ENST00000565796.1_Splice_Site|CDH16_ENST00000568632.1_Splice_Site	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TAGGCCCAATCTGGAGGAGGA	0.617000													14	50					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196398831	196398831	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:196398831G>A	ENST00000367433.5	-	9	796	c.695C>T	c.(694-696)tCc>tTc	p.S232F	KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.S232F|KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000367431.4_Missense_Mutation_p.S232F			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	232						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity	p.S232F(1)		NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						GAAATAAAGGGAGTCAAAGAG	0.388000													15	56					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128298072	128298072	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:128298072G>A	ENST00000368227.3	-	27	4256	c.3890C>T	c.(3889-3891)tCc>tTc	p.S1297F	PTPRK_ENST00000532331.1_Missense_Mutation_p.S1302F|PTPRK_ENST00000368226.4_Missense_Mutation_p.S1280F|PTPRK_ENST00000368215.3_Missense_Mutation_p.S1279F|PTPRK_ENST00000368210.3_Missense_Mutation_p.S1298F|PTPRK_ENST00000368207.3_Missense_Mutation_p.S1312F|PTPRK_ENST00000368213.5_Missense_Mutation_p.S1286F			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1279	Tyrosine-protein phosphatase 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ATTAACCTGGGACAAGTCGAC	0.358000													15	74					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900853	51900853	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:51900853C>T	ENST00000268919.4	+	1	615	c.459C>T	c.(457-459)atC>atT	p.I153I		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	153					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TCTGGGAAATCCAGAAACTGC	0.557000													23	89					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137717798	137717798	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:137717798T>G	ENST00000343735.4	+	1	222	c.88T>G	c.(88-90)Tgg>Ggg	p.W30G		NM_001002026.2	NP_001002026.1	P56856	CLD18_HUMAN	claudin 18	30					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						CATGGACCAGTGGAGCACCCA	0.582000													16	75					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129712776	129712776	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:129712776G>A	ENST00000421865.2	+	36	5261	c.5212G>A	c.(5212-5214)Gaa>Aaa	p.E1738K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1738	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.E1738K(1)		NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GACACAAAAGGAAATTGCTGA	0.343000													17	98					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45949808	45949808	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:45949808C>T	ENST00000323084.4	-	5	728	c.663G>A	c.(661-663)ccG>ccA	p.P221P	TSPEAR_ENST00000397916.1_Silent_p.P153P	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	221	TSP N-terminal.				cell adhesion	extracellular region	structural molecule activity	p.P221P(1)		breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CGTCTGAGCCCGGCAGCAGGA	0.682000													6	22					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82879512	82879512	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:82879512C>T	ENST00000298281.4	+	8	2587	c.2135C>T	c.(2134-2136)cCa>cTa	p.P712L		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	712	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GATCGTTTTCCACTTAAGCGA	0.363000													14	53					0	0	1	0	0
SLC6A12	6539	broad.mit.edu	37	12	306646	306646	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:306646G>A	ENST00000428720.1	-	10	1715	c.972C>T	c.(970-972)ttC>ttT	p.F324F	SLC6A12_ENST00000536824.1_Silent_p.F324F|SLC6A12_ENST00000359674.4_Silent_p.F324F|SLC6A12_ENST00000424061.2_Silent_p.F324F|SLC6A12_ENST00000397296.2_Silent_p.F324F	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	324					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			CACTGTTCAGGAAGCAGAGGG	0.572000													6	25					0	0	1	0	0
CD101	9398	broad.mit.edu	37	1	117568357	117568357	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:117568357C>T	ENST00000256652.4	+	8	2713	c.2655C>T	c.(2653-2655)taC>taT	p.Y885Y	CD101_ENST00000369470.1_Silent_p.Y885Y|RP11-27K13.3_ENST00000445523.1_RNA	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	885	Ig-like C2-type 7.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGCACTGTTACCGTTCATCCT	0.522000													17	83					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160920382	160920382	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:160920382G>A	ENST00000368029.3	-	5	618	c.561C>T	c.(559-561)ttC>ttT	p.F187F	ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	187	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTCTCTGGAGGAAGCCAGTGT	0.567000													15	124					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210856645	210856645	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:210856645C>T	ENST00000367007.4	-	11	3036	c.2867G>A	c.(2866-2868)aGa>aAa	p.R956K	KCNH1_ENST00000271751.4_Missense_Mutation_p.R983K	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	983	CAD (involved in subunit assembly) (By similarity).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		AAAAATGTCTCTCTCTGATTC	0.468000													30	202					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762363	24762363	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:24762363C>T	ENST00000376451.2	+	2	467	c.207C>T	c.(205-207)atC>atT	p.I69I	KIAA1217_ENST00000376452.3_Silent_p.I351I|KIAA1217_ENST00000458595.1_Silent_p.I351I|KIAA1217_ENST00000307544.6_Silent_p.I69I|KIAA1217_ENST00000396446.1_Silent_p.I69I|KIAA1217_ENST00000396445.1_Silent_p.I69I|KIAA1217_ENST00000376462.1_Silent_p.I271I|KIAA1217_ENST00000376454.3_Silent_p.I351I|KIAA1217_ENST00000430453.2_Silent_p.I272I			Q5T5P2	SKT_HUMAN	KIAA1217	351					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGGACAGAATCTCCAGCCTGC	0.552000													20	87					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17349574	17349574	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:17349574C>T	ENST00000242057.4	+	2	723	c.80C>T	c.(79-81)cCa>cTa	p.P27L		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	27					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AAGCCAATCCCAGCTGAAGGA	0.363000													8	45					0	0	1	0	0
STOML3	161003	broad.mit.edu	37	13	39544347	39544347	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr13:39544347C>T	ENST00000379631.4	-	5	835	c.491G>A	c.(490-492)cGa>cAa	p.R164Q	STOML3_ENST00000423210.1_Missense_Mutation_p.R155Q	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	164						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GATCTCTTCTCGTCCAGCTAA	0.408000													22	82					0	0	1	0	0
S100A12	6283	broad.mit.edu	37	1	153346320	153346320	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:153346320G>A	ENST00000368737.3	-	3	379	c.262C>T	c.(262-264)Cac>Tac	p.H88Y		NM_005621.1	NP_005612.1	P80511	S10AC_HUMAN	S100 calcium binding protein A12	88					defense response to bacterium|defense response to fungus|inflammatory response|innate immune response|killing of cells of other organism|positive regulation of I-kappaB kinase/NF-kappaB cascade|xenobiotic metabolic process	cytosol|extracellular region|insoluble fraction|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			endometrium(1)|kidney(1)|skin(2)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)		Amlexanox(DB01025)	TTGTGGGTGTGGTAATGGGCA	0.478000													26	70					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190430274	190430274	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:190430274G>A	ENST00000261024.2	-	6	992	c.566C>T	c.(565-567)cCc>cTc	p.P189L		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	189					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			AACAGCCATGGGGGCTAAGAT	0.483000													16	73					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16257964	16257964	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:16257964C>T	ENST00000375759.3	+	11	5433	c.5229C>T	c.(5227-5229)tcC>tcT	p.S1743S		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1743					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCTCGTTTTCCCAGGCAGAGA	0.557000													42	213					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5111818	5111818	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:5111818C>T	ENST00000381759.4	+	12	1525	c.1318C>T	c.(1318-1320)Cgc>Tgc	p.R440C	KDM4B_ENST00000159111.4_Intron|KDM4B_ENST00000536461.1_Intron			O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	0					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						gtctcgactccgcatggcaac	0.547000													5	41					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66944275	66944275	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:66944275G>A	ENST00000299752.4	-	15	2248	c.2055C>T	c.(2053-2055)atC>atT	p.I685I	CDH16_ENST00000394055.3_Silent_p.I663I|CDH16_ENST00000570262.1_Silent_p.I605I|CDH16_ENST00000565796.1_Silent_p.I646I|CDH16_ENST00000568632.1_Silent_p.I588I	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	685	Ectodomain G.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GTCCACTCACGATCAAGCCAT	0.637000													9	63					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413391	124413391	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:124413391G>A	ENST00000306842.2	-	1	184	c.160C>T	c.(160-162)Ctg>Ttg	p.L54L		NM_001005195.1	NP_001005195.1	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B, member 12	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		GGAGTGTGCAGGTGAGAGTTC	0.483000													19	90					0	0	1	0	0
SCTR	6344	broad.mit.edu	37	2	120236408	120236408	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:120236408G>A	ENST00000019103.5	-	3	547	c.280C>T	c.(280-282)Cgg>Tgg	p.R94W	AC013275.2_ENST00000413602.1_RNA|AC013275.2_ENST00000457436.1_RNA	NM_002980.2	NP_002971.2	P47872	SCTR_HUMAN	secretin receptor	94					digestion|excretion	integral to plasma membrane	secretin receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)	19					Secretin(DB00021)	GTGAGCATCCGGAGGAATCTC	0.622000													9	57					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14559293	14559293	+	RNA	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:14559293C>T	ENST00000273083.3	-	0	1207							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						GGCTTTGGTCCTGGCCAGCAG	0.647000													3	8					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6238657	6238657	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:6238657G>A	ENST00000265978.4	-	9	2559	c.2201C>T	c.(2200-2202)cCc>cTc	p.P734L	FAM160A2_ENST00000449352.2_Missense_Mutation_p.P720L|FAM160A2_ENST00000524416.1_Missense_Mutation_p.P720L	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	720					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCTGAGGAAGGGGCCAGGGGG	0.597000													12	73					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44073392	44073392	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:44073392C>T	ENST00000272286.2	+	3	354	c.264C>T	c.(262-264)atC>atT	p.I88I		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	88	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGCTGGGCATCCAGAACCTAA	0.552000													9	51					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9058027	9058027	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:9058027G>A	ENST00000397910.4	-	3	29622	c.29419C>T	c.(29419-29421)Cat>Tat	p.H9807Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9809	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGGAAGGATGAATTTTCTCT	0.448000													17	82					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77211094	77211094	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr18:77211094C>T	ENST00000253506.5	+	5	2099	c.1730C>T	c.(1729-1731)tCc>tTc	p.S577F	NFATC1_ENST00000397790.2_Missense_Mutation_p.S105F|NFATC1_ENST00000329101.4_Missense_Mutation_p.S564F|NFATC1_ENST00000591814.1_Missense_Mutation_p.S577F|NFATC1_ENST00000586434.1_Missense_Mutation_p.S564F|NFATC1_ENST00000318065.5_Missense_Mutation_p.S564F|NFATC1_ENST00000545796.1_Missense_Mutation_p.S105F|NFATC1_ENST00000587635.1_Intron|NFATC1_ENST00000542384.1_Missense_Mutation_p.S577F|NFATC1_ENST00000427363.2_Missense_Mutation_p.S577F|NFATC1_ENST00000592223.1_Missense_Mutation_p.S564F	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	577	RHD.				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CGCACGCTGTCCCTGCAGGTG	0.622000													22	93					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361149	70361149	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:70361149C>T	ENST00000305107.6	-	1	477	c.431G>A	c.(430-432)aGa>aAa	p.R144K	UGT2B4_ENST00000512583.1_Missense_Mutation_p.R144K|UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000381096.3_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	144					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						AACATCAAATCTTGACTCCTG	0.393000													11	43					0	0	1	0	0
THAP2	83591	broad.mit.edu	37	12	72070870	72070870	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:72070870C>T	ENST00000308086.2	+	3	2170	c.669C>T	c.(667-669)acC>acT	p.T223T	RP11-293I14.2_ENST00000548802.1_Intron	NM_031435.3	NP_113623.1	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated protein 2	223						nucleolus	DNA binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	10						TAAAACAGACCAAGAGTACCT	0.343000													10	48					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196671552	196671552	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:196671552G>A	ENST00000312428.6	-	54	10188	c.10088C>T	c.(10087-10089)cCa>cTa	p.P3363L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3363					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTCATGGTGTGGTTCCTAAAA	0.323000													12	40					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67188746	67188746	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:67188746G>A	ENST00000269081.4	-	17	2738	c.1829C>T	c.(1828-1830)tCt>tTt	p.S610F	ABCA10_ENST00000416101.2_3'UTR	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	610	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					CAGAAACAAAGATGATCCTGC	0.318000													12	123					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10858146	10858146	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:10858146G>A	ENST00000254488.2	+	1	262	c.196G>A	c.(196-198)Gag>Aag	p.E66K	SLC6A11_ENST00000454147.1_Missense_Mutation_p.E66K	NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	66					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CGTGGCCGGGGAGATCATTGG	0.677000													4	26					0	0	1	0	0
KCNE4	23704	broad.mit.edu	37	2	223917937	223917937	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:223917937C>T	ENST00000281830.3	+	2	873	c.542C>T	c.(541-543)tCc>tTc	p.S181F	KCNE4_ENST00000604125.1_Missense_Mutation_p.S130F|KCNE4_ENST00000488477.2_Intron			Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related family, member 4	130						integral to membrane	voltage-gated potassium channel activity			large_intestine(2)|lung(5)|ovary(2)|skin(1)	10		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCCGAGTCCTCCTCCCCGGAC	0.657000													5	26					0	0	1	0	0
SPHK2	56848	broad.mit.edu	37	19	49131969	49131969	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49131969C>A	ENST00000443164.1	+	5	1795	c.1090C>A	c.(1090-1092)Ctc>Atc	p.L364I	SPHK2_ENST00000598088.1_Missense_Mutation_p.L302I|SPHK2_ENST00000340932.3_Intron|SPHK2_ENST00000245222.4_Missense_Mutation_p.L302I|SPHK2_ENST00000600537.1_Missense_Mutation_p.L243I|SPHK2_ENST00000599029.1_Missense_Mutation_p.L266I|SPHK2_ENST00000599748.1_Missense_Mutation_p.L266I			Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	302					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CGACCTGTTGCTCAACTGCTC	0.607000													5	66					0.00198382	0.00200305	1	1	0
ADAMTS18	170692	broad.mit.edu	37	16	77331198	77331198	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:77331198G>A	ENST00000282849.5	-	18	3207	c.2789C>T	c.(2788-2790)tCc>tTc	p.S930F		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	930					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						AGCCGGGCAGGAGAAAGCGTT	0.403000													18	123					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53643934	53643934	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:53643934G>A	ENST00000342160.3	-	20	2411	c.1954C>T	c.(1954-1956)Ctt>Ttt	p.L652F	HUWE1_ENST00000262854.6_Missense_Mutation_p.L652F|HUWE1_ENST00000218328.8_Missense_Mutation_p.L652F			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	652					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AACTTACCAAGGGGATCAGAA	0.403000													7	16					0	0	1	0	0
CLDN18	51208	broad.mit.edu	37	3	137717797	137717797	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:137717797G>A	ENST00000343735.4	+	1	221	c.87G>A	c.(85-87)caG>caA	p.Q29Q		NM_001002026.2	NP_001002026.1	P56856	CLD18_HUMAN	claudin 18	29					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	6						GCATGGACCAGTGGAGCACCC	0.582000													16	76					0	0	1	0	0
GPR107	57720	broad.mit.edu	37	9	132837948	132837948	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr9:132837948T>A	ENST00000372406.1	+	2	682	c.175T>A	c.(175-177)Ttt>Att	p.F59I	GPR107_ENST00000372410.3_Missense_Mutation_p.F59I|GPR107_ENST00000347136.6_Missense_Mutation_p.F59I	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	59						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				TCTGAACACCTTTGGCTTCTT	0.388000													5	43					0	0	1	0	0
PRF1	5551	broad.mit.edu	37	10	72358718	72358718	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:72358718C>T	ENST00000441259.1	-	3	919	c.759G>A	c.(757-759)gaG>gaA	p.E253E	PRF1_ENST00000373209.2_Silent_p.E253E	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	253	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						AGTCCTCCACCTCGTTGTCCG	0.632000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				7	44					0	0	1	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185407273	185407273	+	Missense_Mutation	SNP	G	G	A	rs11558676		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:185407273G>A	ENST00000382199.2	-	6	642	c.547C>T	c.(547-549)Cct>Tct	p.P183S	IGF2BP2_ENST00000421047.2_Missense_Mutation_p.P126S|IGF2BP2_ENST00000346192.3_Missense_Mutation_p.P183S|IGF2BP2_ENST00000457616.2_Missense_Mutation_p.P189S	NM_006548.4	NP_006539.3	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding protein 2	183					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	20	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			GTGCCCCCAGGGGCGTGGCCT	0.612000													15	94					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72184698	72184698	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:72184698G>A	ENST00000537465.1	-	5	603	c.445C>T	c.(445-447)Cac>Tac	p.H149Y	PMFBP1_ENST00000237353.10_Missense_Mutation_p.H149Y|PMFBP1_ENST00000355636.6_Missense_Mutation_p.H4Y			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	149										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TTCTCGTTGTGATTTCCCATT	0.502000													13	85					0	0	1	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754313	140754313	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:140754313C>T	ENST00000517434.1	+	1	663	c.663C>T	c.(661-663)gtC>gtT	p.V221V	PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGACCCTGTCCGCTCAAGCG	0.557000													3	12					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874582	36874582	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:36874582C>T	ENST00000429976.2	-	21	6607	c.6360G>A	c.(6358-6360)gtG>gtA	p.V2120V	TRANK1_ENST00000301807.6_Silent_p.V1570V|TRANK1_ENST00000428977.2_Silent_p.V1570V			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2120					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GGGCTAATTTCACTTGGTCAG	0.413000													4	21					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50948764	50948764	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:50948764C>T	ENST00000374103.4	-	16	2217	c.2132G>A	c.(2131-2133)gGa>gAa	p.G711E	OGDHL_ENST00000419399.1_Missense_Mutation_p.G654E|OGDHL_ENST00000432695.1_Missense_Mutation_p.G502E	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	711					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						ACCCAGGACTCCGTACTCCGA	0.657000													7	24					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2924840	2924840	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:2924840G>A	ENST00000397461.1	+	8	1048	c.664G>A	c.(664-666)Gaa>Aaa	p.E222K	CNTN4_ENST00000418658.1_Missense_Mutation_p.E222K|CNTN4_ENST00000358480.3_Missense_Mutation_p.E3K|CNTN4_ENST00000427331.1_Missense_Mutation_p.E222K	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	222					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding	p.E222*(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGTGATGGGTGAATATGAGCC	0.373000													4	25					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66920910	66920910	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:66920910A>C	ENST00000269080.2	-	10	1511	c.1374T>G	c.(1372-1374)gaT>gaG	p.D458E	ABCA8_ENST00000430352.2_Missense_Mutation_p.D458E|ABCA8_ENST00000586539.1_Missense_Mutation_p.D458E	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	458						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					AAGGATCGGCATCCATTTCAT	0.448000													22	134					0	0	1	0	0
TMEM89	440955	broad.mit.edu	37	3	48658291	48658291	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:48658291G>A	ENST00000330862.3	-	2	562	c.464C>T	c.(463-465)tCc>tTc	p.S155F		NM_001008269.1	NP_001008270.1	A2RUT3	TMM89_HUMAN	transmembrane protein 89	155						integral to membrane				breast(1)|lung(1)|stomach(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		ACTCTGGGTGGAAGTCCCCTT	0.602000													18	108					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670958	49670958	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr16:49670958G>A	ENST00000561648.1	-	4	2158	c.2105C>T	c.(2104-2106)tCc>tTc	p.S702F	ZNF423_ENST00000567169.1_Missense_Mutation_p.S585F|ZNF423_ENST00000262383.2_Missense_Mutation_p.S702F|ZNF423_ENST00000535559.1_Missense_Mutation_p.S585F|ZNF423_ENST00000563137.2_Missense_Mutation_p.S642F|ZNF423_ENST00000562520.1_Missense_Mutation_p.S642F|ZNF423_ENST00000562871.1_Missense_Mutation_p.S642F	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	702					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				ATCCACCGAGGAAAATTGCTT	0.552000													8	58					0	0	1	0	0
LYPLA2	11313	broad.mit.edu	37	1	24120591	24120591	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:24120591C>T	ENST00000374514.3	+	7	641	c.334C>T	c.(334-336)Cct>Tct	p.P112S	LYPLA2_ENST00000374503.3_Missense_Mutation_p.P112S|LYPLA2_ENST00000374502.3_Missense_Mutation_p.P112S|LYPLA2_ENST00000495365.1_3'UTR|LYPLA2_ENST00000374505.2_Intron|LYPLA2_ENST00000374501.1_Missense_Mutation_p.P45S|LYPLA2_ENST00000400061.1_Intron	NM_007260.2	NP_009191.1	O95372	LYPA2_HUMAN	lysophospholipase II	112					fatty acid metabolic process	cytoplasm	hydrolase activity			endometrium(3)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		GAACGGGATCCCTGCCAATCG	0.607000													13	88					0	0	1	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	45999696	45999696	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:45999696G>A	ENST00000400372.1	-	1	785	c.760C>T	c.(760-762)Ccg>Tcg	p.P254S	TSPEAR_ENST00000323084.4_Intron	NM_198694.2	NP_941967.2	P60370	KR105_HUMAN	keratin associated protein 10-5	254	22 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(2)|kidney(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	14						CAGGAGGCCGGGCGGCAGCAG	0.706000													10	62					0	0	1	0	0
CXorf57	55086	broad.mit.edu	37	X	105905473	105905473	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chrX:105905473C>T	ENST00000372548.4	+	12	2316	c.2207C>T	c.(2206-2208)cCc>cTc	p.P736L	CXorf57_ENST00000497124.1_3'UTR|CXorf57_ENST00000372544.2_Missense_Mutation_p.P639L	NM_018015.5	NP_060485.4	Q6NSI4	CX057_HUMAN	chromosome X open reading frame 57	736										NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	31						GAAGGAAGGCCCCCAAAACTT	0.383000													29	49					0	0	1	0	0
ICAM3	3385	broad.mit.edu	37	19	10449604	10449604	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:10449604G>A	ENST00000160262.5	-	2	305	c.97C>T	c.(97-99)Ctt>Ttt	p.L33F	ICAM3_ENST00000589261.1_5'UTR	NM_002162.3	NP_002153.2	P32942	ICAM3_HUMAN	intercellular adhesion molecule 3	33					cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	13			OV - Ovarian serous cystadenocarcinoma(20;6.13e-09)|Epithelial(33;9.69e-06)|all cancers(31;2.05e-05)			ACCCGCAAAAGGAACTCCTGC	0.547000													15	48					0	0	1	0	0
S1PR2	9294	broad.mit.edu	37	19	10335081	10335081	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:10335081G>A	ENST00000590320.1	-	2	611	c.501C>T	c.(499-501)atC>atT	p.I167I		NM_004230.3	NP_004221.3	O95136	S1PR2_HUMAN	sphingosine-1-phosphate receptor 2	167					activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						TCCAGCCAAGGATGGGCAGGC	0.607000													13	55					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059444	248059444	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:248059444C>T	ENST00000537741.1	+	3	813	c.556C>T	c.(556-558)Cgg>Tgg	p.R186W	OR2W3_ENST00000360358.3_Missense_Mutation_p.R186W			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CGCCCTGATCCGGATGGCCTG	0.622000													17	102					0	0	1	0	0
ZNF329	79673	broad.mit.edu	37	19	58639442	58639442	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:58639442G>A	ENST00000598312.1	-	4	1662	c.1429C>T	c.(1429-1431)Cac>Tac	p.H477Y	ZNF329_ENST00000358067.4_Missense_Mutation_p.H477Y	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	477					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TCCTTAGTGTGAATTCTCTGG	0.517000													24	83					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142749631	142749631	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:142749631C>T	ENST00000418316.1	+	1	215	c.194C>T	c.(193-195)tCc>tTc	p.S65F		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					GGCAATTTTTCCCTGCTGGAG	0.493000													30	176					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73964968	73964968	+	Missense_Mutation	SNP	C	C	G	rs140104691		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:73964968C>G	ENST00000553558.1	-	14	2758	c.2437G>C	c.(2437-2439)Gta>Cta	p.V813L	HEATR4_ENST00000334988.2_Missense_Mutation_p.V813L|HEATR4_ENST00000560393.1_Missense_Mutation_p.V766L	NM_001220484.1	NP_001207413.1			HEAT repeat containing 4											breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TCCAGCCGTACACCTGGTGAC	0.562000													9	27					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26688384	26688384	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:26688384G>A	ENST00000436292.1	-	7	1453	c.1333C>T	c.(1333-1335)Cat>Tat	p.H445Y	ZNF683_ENST00000403843.1_Missense_Mutation_p.H445Y|ZNF683_ENST00000374204.1_Missense_Mutation_p.H425Y|ZNF683_ENST00000349618.3_Missense_Mutation_p.H425Y			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		TGCAGCCGATGGTGCAGCTTC	0.662000													10	59					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116975511	116975511	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr10:116975511G>A	ENST00000355044.3	+	9	1531	c.1405G>A	c.(1405-1407)Ggc>Agc	p.G469S		NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	469						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGGTGGATATGGCCATACTAG	0.333000													4	41					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113085146	113085146	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:113085146G>A	ENST00000316851.7	+	7	942	c.942G>A	c.(940-942)caG>caA	p.Q314Q	NCAM1_ENST00000533760.1_Silent_p.Q206Q|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Silent_p.Q323Q	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	324	Ig-like C2-type 4.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TAGAGGAGCAGGTCACTCTTA	0.458000													5	25					0	0	1	0	0
UPP2	151531	broad.mit.edu	37	2	158962718	158962718	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:158962718G>A	ENST00000605860.1	+	5	387	c.341G>A	c.(340-342)gGa>gAa	p.G114E	UPP2_ENST00000005756.4_Missense_Mutation_p.G57E|UPP2_ENST00000409859.4_Missense_Mutation_p.G114E|UPP2_ENST00000460456.1_3'UTR			O95045	UPP2_HUMAN	uridine phosphorylase 2	57					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						GCAATGTTTGGAGATGTAAAG	0.323000													10	36					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103301844	103301844	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr7:103301844G>A	ENST00000428762.1	-	12	1579	c.1420C>T	c.(1420-1422)Ctg>Ttg	p.L474L	RELN_ENST00000343529.5_Silent_p.L474L|RELN_ENST00000424685.2_Silent_p.L474L	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	474					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TAAAACCTCAGGTTCCCATAA	0.433000													15	58					0	0	1	0	0
AMIGO1	57463	broad.mit.edu	37	1	110050303	110050303	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:110050303C>T	ENST00000369864.4	-	2	1581	c.1232G>A	c.(1231-1233)gGa>gAa	p.G411E	AMIGO1_ENST00000369862.1_Missense_Mutation_p.G411E			Q86WK6	AMGO1_HUMAN	adhesion molecule with Ig-like domain 1	411					axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		GAGGCTGTCTCCTTGATGGCT	0.557000													14	67					0	0	1	0	0
CCDC92	80212	broad.mit.edu	37	12	124421867	124421867	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:124421867G>A	ENST00000545135.1	-	3	3979	c.683C>T	c.(682-684)cCa>cTa	p.P228L	CCDC92_ENST00000238156.3_Missense_Mutation_p.P245L|CCDC92_ENST00000544798.1_Intron|CCDC92_ENST00000545891.1_Missense_Mutation_p.P228L			Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	245										large_intestine(5)|lung(2)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		CAGCAGAAATGGGGTGGGGTC	0.622000													14	50					0	0	1	0	0
SMR3B	10879	broad.mit.edu	37	4	71255498	71255498	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr4:71255498G>A	ENST00000304915.3	+	3	322	c.173G>A	c.(172-174)aGa>aAa	p.R58K	SMR3B_ENST00000504825.1_Missense_Mutation_p.R58K	NM_006685.3	NP_006676.1			submaxillary gland androgen regulated protein 3B									p.R58K(1)		large_intestine(2)|lung(3)|skin(2)	7		all_hematologic(202;0.196)				GGTCCAGGGAGAATCCCACCT	0.602000													30	120					0	0	1	0	0
SHKBP1	92799	broad.mit.edu	37	19	41092699	41092699	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:41092699C>T	ENST00000291842.5	+	13	1234	c.1185C>T	c.(1183-1185)atC>atT	p.I395I	SHKBP1_ENST00000597649.1_3'UTR|SHKBP1_ENST00000600733.1_Silent_p.I370I	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	395						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGAACTGGATCGAGATCGCCT	0.622000													14	73					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	50149724	50149724	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:50149724C>T	ENST00000451037.2	-	2	1031	c.91G>A	c.(91-93)Ggc>Agc	p.G31S	CA10_ENST00000570565.1_5'UTR|CA10_ENST00000340813.6_Missense_Mutation_p.G37S|CA10_ENST00000285273.4_Missense_Mutation_p.G31S|CA10_ENST00000442502.2_Missense_Mutation_p.G31S	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	31					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GCCCACCAGCCTTCATGGATT	0.398000													22	82					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921574	247921574	+	Silent	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:247921574G>A	ENST00000408896.2	-	1	408	c.135C>T	c.(133-135)atC>atT	p.I45I		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCGTCGCAATGATGAGCATGT	0.493000													11	32					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121748012	121748012	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr2:121748012C>T	ENST00000452319.1	+	14	4582	c.4522C>T	c.(4522-4524)Ccc>Tcc	p.P1508S	GLI2_ENST00000361492.4_Missense_Mutation_p.P1508S|GLI2_ENST00000314490.11_Intron			P10070	GLI2_HUMAN	GLI family zinc finger 2	1508					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCTGGAGGCCCCCCAGATTGA	0.617000													22	116					0	0	1	0	0
LSS	4047	broad.mit.edu	37	21	47614411	47614411	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:47614411G>A	ENST00000397728.3	-	20	2060	c.1982C>T	c.(1981-1983)gCc>gTc	p.A661V	LSS_ENST00000356396.4_Missense_Mutation_p.A661V|LSS_ENST00000457828.2_Missense_Mutation_p.A581V|LSS_ENST00000522411.1_Missense_Mutation_p.A650V	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	661					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					CCACCGAACGGCCATCAGCCC	0.617000													8	23					0	0	1	0	0
CRELD1	78987	broad.mit.edu	37	3	9979724	9979724	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr3:9979724C>T	ENST00000383811.3	+	4	993	c.394C>T	c.(394-396)Cag>Tag	p.Q132*	CRELD1_ENST00000397170.3_Nonsense_Mutation_p.Q132*|CRELD1_ENST00000452070.1_Nonsense_Mutation_p.Q132*|CRELD1_ENST00000326434.5_Nonsense_Mutation_p.Q132*	NM_015513.4	NP_056328.2	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1	132					cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|urinary_tract(1)	14						GGACCTCTTCCAGTGGCTGTG	0.622000													9	25					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158687671	158687671	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:158687671G>A	ENST00000368146.1	-	1	282	c.283C>T	c.(283-285)Ccc>Tcc	p.P95S	OR6K3_ENST00000368145.1_Missense_Mutation_p.P79S			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					AGCATCTTGGGAATGGTGGCT	0.453000													70	203					0	0	1	0	0
PITPNB	23760	broad.mit.edu	37	22	28256204	28256204	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr22:28256204C>A	ENST00000335272.5	-	9	636	c.560G>T	c.(559-561)tGt>tTt	p.C187F	PITPNB_ENST00000320996.10_Missense_Mutation_p.C187F|PITPNB_ENST00000455418.3_Missense_Mutation_p.C189F	NM_012399.3	NP_036531.1	P48739	PIPNB_HUMAN	phosphatidylinositol transfer protein, beta	187					lipid metabolic process|transport	Golgi apparatus	lipid binding			large_intestine(4)|lung(3)|skin(1)	8						CATCTGGGGACAGTCAGGGCT	0.363000													6	29					0.248553	0.248553	1	1	0
LTA4H	4048	broad.mit.edu	37	12	96397680	96397680	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:96397680G>T	ENST00000228740.2	-	17	1690	c.1549C>A	c.(1549-1551)Cac>Aac	p.H517N	RP11-256L6.3_ENST00000551849.1_RNA|LTA4H_ENST00000552789.1_Missense_Mutation_p.H493N|LTA4H_ENST00000413268.2_Intron	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	517					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						CGCTTTATGTGCCCCAATGGA	0.398000													4	44					0.0381472	0.0382522	1	1	0
RASIP1	54922	broad.mit.edu	37	19	49224197	49224197	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr19:49224197G>A	ENST00000222145.4	-	12	2954	c.2750C>T	c.(2749-2751)tCg>tTg	p.S917L		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	917					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GCGCAGGCGCGAGCTCCCCAG	0.652000													8	26					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24520729	24520729	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr6:24520729C>T	ENST00000357578.3	+	6	1116	c.971C>T	c.(970-972)gCt>gTt	p.A324V	ALDH5A1_ENST00000348925.2_Missense_Mutation_p.A337V|ALDH5A1_ENST00000491546.1_Missense_Mutation_p.A296V|ALDH5A1_ENST00000546278.1_Missense_Mutation_p.A236V	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	324					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	GTGGACCAGGCTGTAGCAGGG	0.507000													17	81					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70527622	70527622	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr14:70527622C>T	ENST00000381269.2	-	3	2572	c.1819G>A	c.(1819-1821)Gaa>Aaa	p.E607K	SLC8A3_ENST00000216568.7_5'UTR|SLC8A3_ENST00000528359.1_Intron|SLC8A3_ENST00000394330.2_Intron|SLC8A3_ENST00000356921.2_Missense_Mutation_p.E607K|SLC8A3_ENST00000357887.3_Intron|SLC8A3_ENST00000533899.1_5'UTR|SLC8A3_ENST00000533541.1_Intron|SLC8A3_ENST00000534137.1_Missense_Mutation_p.E607K	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	607	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CTTTCGTATTCCTCCTCATCT	0.428000													17	68					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103814205	103814205	+	Silent	SNP	C	C	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:103814205C>T	ENST00000302251.5	-	5	1180	c.729G>A	c.(727-729)agG>agA	p.R243R	PDGFD_ENST00000393158.2_Silent_p.R249R	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	249					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CATGGTATGACCTGCCTCGAT	0.418000													5	36					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57349354	57349354	+	Splice_Site	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:57349354G>A	ENST00000361249.3	+	6	951	c.855_splice	c.e6+1	p.K285_splice		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	285	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						ATAATGAGAAGGTATTCAAAC	0.383000													16	46					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359606	66359606	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:66359606G>A	ENST00000333861.3	-	1	948	c.881C>T	c.(880-882)aCc>aTc	p.T294I		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	294										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						AGCCCTGCTGGTGGGGGCCAC	0.597000													11	74					0	0	1	0	0
BOLA1	51027	broad.mit.edu	37	1	149871861	149871863	+	In_Frame_Del	DEL	ACA	ACA	-			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:149871861_149871863delACA	ENST00000369153.2	+	3	913_915	c.249_251delACA	c.(247-252)cta>ct	p.LQ83del	BOLA1_ENST00000369152.5_In_Frame_Del_p.LQ83del|BOLA1_ENST00000369150.1_In_Frame_Del_p.LQ83del|BOLA1_ENST00000476344.1_3'UTR			Q9Y3E2	BOLA1_HUMAN	bolA family member 1	83						extracellular region	protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	10	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TGAGCCCCCTACAACGACACCGG	0.680													9	40	---	---	---	---					
SDCCAG8	10806	broad.mit.edu	37	1	243437890	243437891	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr1:243437890_243437891insT	ENST00000366541.3	+	4	470_471	c.352_353insT	c.(352-354)tgtfs	p.C118fs	SDCCAG8_ENST00000343783.6_Intron|SDCCAG8_ENST00000355875.4_Frame_Shift_Ins_p.C118fs|SDCCAG8_ENST00000391846.1_Frame_Shift_Ins_p.C118fs	NM_006642.3	NP_006633.1	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	118					establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TATGCACGACCTTGTTCATACT	0.277													34	97	---	---	---	---					
FAT2	2196	broad.mit.edu	37	5	150922632	150922633	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr5:150922632_150922633insT	ENST00000261800.5	-	9	8067_8068	c.8055_8056insA	c.(8053-8058)aatatcfs	p.NI2685fs		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2685	Cadherin 23.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTAAGGATACTTTTTTAGGAA	0.460													14	55	---	---	---	---					
ACTN3	89	broad.mit.edu	37	11	66321928	66321928	+	RNA	DEL	A	A	-	rs141435934		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr11:66321928delA	ENST00000513398.1	+	0	566				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						accctgtctcaaaaaaaaaaa	0.537													2	4	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132445250	132445251	+	Frame_Shift_Ins	INS	-	-	G			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr12:132445250_132445251insG	ENST00000333577.4	+	2	195_196	c.86_87insG	c.(85-87)cgcfs	p.R29fs	EP400_ENST00000389562.2_Frame_Shift_Ins_p.R29fs|EP400_ENST00000330386.6_Frame_Shift_Ins_p.R29fs|EP400_ENST00000332482.4_Frame_Shift_Ins_p.R29fs|EP400_ENST00000389561.2_Frame_Shift_Ins_p.R29fs			Q96L91	EP400_HUMAN	E1A binding protein p400	29					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GAGGAGCAGCCGGCCCACCCCA	0.653													2	4	---	---	---	---					
LOC101926911	101926911	broad.mit.edu	37	15	91575679	91575681	+	RNA	DEL	CCT	CCT	-			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr15:91575679_91575681delCCT	ENST00000557804.1	+	0	387_389																											GGCTGAGGCGCCTCCTCCTCCTC	0.635													4	9	---	---	---	---					
C17orf104	284071	broad.mit.edu	37	17	42746811	42746811	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr17:42746811delC	ENST00000409122.2	+	6	2525	c.2383delC	c.(2383-2385)cafs	p.P795fs	C17orf104_ENST00000359945.3_Frame_Shift_Del_p.P795fs|C17orf104_ENST00000409464.1_Frame_Shift_Del_p.P629fs	NM_001145080.2	NP_001138552.2	A2RUB1	CQ104_HUMAN	chromosome 17 open reading frame 104	795										autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|skin(1)	24						TAACAACACTCCAGTTCCAAG	0.363													2	4	---	---	---	---					
AP001604.3	0	broad.mit.edu	37	21	28793489	28793490	+	RNA	INS	-	-	T	rs144948060		TCGA-D9-A3Z1-06A-11D-A23B-08	TCGA-D9-A3Z1-10A-01D-A23B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37cecfce-36fc-4240-adae-75f506475881	3607a6e5-99d1-4bd6-8a37-9380de187000	g.chr21:28793489_28793490insT	ENST00000420186.2	-	0	202																											atttttttttcttttttttttt	0.347													4	4	---	---	---	---