Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTPRJ	5795	broad.mit.edu	37	11	48145321	48145321	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr11:48145321A>G	ENST00000418331.2	+	5	1125	c.773A>G	c.(772-774)aAt>aGt	p.N258S	PTPRJ_ENST00000440289.2_Missense_Mutation_p.N258S	NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	258	Fibronectin type-III 2.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						CTTCAGGTCAATATCTCGGGC	0.502000													26	32					0	0	9.22233e-05	0	0
CXorf66	347487	broad.mit.edu	37	X	139038753	139038753	+	Missense_Mutation	SNP	C	C	T	rs139549978		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chrX:139038753C>T	ENST00000370540.1	-	3	411	c.388G>A	c.(388-390)Gca>Aca	p.A130T		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	130	Ser-rich.					integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						CTGGATTGTGCGGATGCCCTT	0.448000													57	65					0	0	0.000147903	0	0
FBXO39	162517	broad.mit.edu	37	17	6683324	6683324	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr17:6683324G>A	ENST00000321535.4	+	2	267	c.137G>A	c.(136-138)tGg>tAg	p.W46*		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	46	F-box.									NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						TGCAGAAAGTGGAACCAGATG	0.542000													18	18					0	0	7.07596e-05	0	0
FAM105A	54491	broad.mit.edu	37	5	14602345	14602345	+	Silent	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr5:14602345G>A	ENST00000274217.3	+	5	522	c.402G>A	c.(400-402)agG>agA	p.R134R		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	134										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					GACAAGTAAGGAGAGATAACT	0.358000													21	179					0	0	0.000132079	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	RNA	SNP	G	G	A	rs150520281	by1000genomes	TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr16:21817457G>A	ENST00000546471.1	-	0	1601																											CTTACATCCAGCTTGAGTAGT	0.259000													4	37					0	0	1.23904e-05	0	0
GPR116	221395	broad.mit.edu	37	6	46847621	46847621	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr6:46847621C>T	ENST00000283296.7	-	9	1258	c.970G>A	c.(970-972)Gca>Aca	p.A324T	GPR116_ENST00000265417.7_Missense_Mutation_p.A324T|GPR116_ENST00000362015.4_Missense_Mutation_p.A324T|GPR116_ENST00000456426.2_Intron	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	324	Ig-like 1.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.A324T(1)		breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			TTGAAAAGTGCGGTGTAAATC	0.463000													32	63					0	0	8.91981e-05	0	0
OR4C13	283092	broad.mit.edu	37	11	49974394	49974394	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr11:49974394C>A	ENST00000555099.1	+	1	452	c.420C>A	c.(418-420)agC>agA	p.S140R		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S140S(1)		autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						ATGTTTGTAGCCTGCTAGTGG	0.468000													28	43					3.1745e-13	3.24592e-11	0.000227799	1	0
ZNF341	84905	broad.mit.edu	37	20	32341106	32341106	+	Silent	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr20:32341106C>T	ENST00000375200.1	+	5	983	c.618C>T	c.(616-618)ccC>ccT	p.P206P	ZNF341_ENST00000342427.2_Silent_p.P206P			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GCCTGGGCCCCCCTGGGCGTC	0.692000													11	7					0	0	3.86212e-05	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671704	39671704	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr21:39671704G>A	ENST00000398930.1	+	4	875	c.521G>A	c.(520-522)cGg>cAg	p.R174Q	KCNJ15_ENST00000398938.2_Missense_Mutation_p.R174Q|KCNJ15_ENST00000328656.3_Missense_Mutation_p.R174Q|KCNJ15_ENST00000398932.1_Missense_Mutation_p.R174Q|KCNJ15_ENST00000398934.1_Missense_Mutation_p.R174Q			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	174					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						CCCAAAAAGCGGGCTGAGACC	0.507000													48	3					0	0	0.000106405	0	0
CTR9	9646	broad.mit.edu	37	11	10791757	10791757	+	Splice_Site	SNP	T	T	G			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr11:10791757T>G	ENST00000361367.2	+	17	2536	c.2109_splice	c.e17-1	p.Y704_splice		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	704					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		TTTACTGTAGTATGAAAACTG	0.348000													16	16					0	0	5.01169e-05	0	0
CSMD2	114784	broad.mit.edu	37	1	34033216	34033216	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:34033216G>A	ENST00000373381.4	-	53	8533	c.8357C>T	c.(8356-8358)tCg>tTg	p.S2786L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2763	Sushi 19.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGTCTTGCCCGACCAGTGATG	0.522000													46	2					0	0	0.000147903	0	0
CBLB	868	broad.mit.edu	37	3	105421139	105421139	+	Silent	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr3:105421139C>T	ENST00000264122.4	-	12	2079	c.1758G>A	c.(1756-1758)ccG>ccA	p.P586P	CBLB_ENST00000394027.3_Silent_p.P608P|CBLB_ENST00000405772.1_Silent_p.P586P|CBLB_ENST00000403724.1_Silent_p.P586P	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	586	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						GAGGCATTGGCGGGTCTCTGG	0.542000			Mis S		AML								10	29					0	0	3.86212e-05	0	0
ZNF589	51385	broad.mit.edu	37	3	48309500	48309500	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr3:48309500A>G	ENST00000354698.3	+	4	391	c.319A>G	c.(319-321)Att>Gtt	p.I107V	ZNF589_ENST00000412564.1_Intron|ZNF589_ENST00000440261.2_Missense_Mutation_p.I106V|ZNF589_ENST00000427617.2_Intron	NM_016089.2	NP_057173.2	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	107	KRAB.				regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CAATCATCCTATTCCAGGTTT	0.507000													15	36					0	0	3.45872e-05	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47614759	47614759	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr20:47614759G>A	ENST00000371917.4	+	24	3251	c.3251G>A	c.(3250-3252)gGa>gAa	p.G1084E	ARFGEF2_ENST00000493140.1_3'UTR	NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	1084					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AGACTGGATGGAAATGCAATA	0.448000													16	18					0	0	0.000132079	0	0
TBC1D15	64786	broad.mit.edu	37	12	72307701	72307701	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr12:72307701C>T	ENST00000550746.1	+	13	1511	c.1447C>T	c.(1447-1449)Caa>Taa	p.Q483*	TBC1D15_ENST00000485960.2_Nonsense_Mutation_p.Q466*|TBC1D15_ENST00000548679.1_3'UTR|TBC1D15_ENST00000319106.8_Nonsense_Mutation_p.Q474*|TBC1D15_ENST00000393309.3_Nonsense_Mutation_p.Q237*	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	483	Rab-GAP TBC.						protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TTACATGGACCAAATGGTAAG	0.308000													573	565					0	0	0.000147903	0	0
SASH1	23328	broad.mit.edu	37	6	148865579	148865579	+	Silent	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr6:148865579G>A	ENST00000367467.3	+	18	3448	c.2973G>A	c.(2971-2973)aaG>aaA	p.K991K		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	991	Pro-rich.						protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CTGCCAAAAAGAGCAGAGAAC	0.587000													40	45					0	0	0.000125731	0	0
PASK	23178	broad.mit.edu	37	2	242063523	242063523	+	Silent	SNP	C	C	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr2:242063523C>A	ENST00000403638.3	-	11	2836	c.2745G>T	c.(2743-2745)gtG>gtT	p.V915V	PASK_ENST00000234040.4_Silent_p.V915V|PASK_ENST00000539818.1_Silent_p.V699V|PASK_ENST00000544142.1_Silent_p.V729V|PASK_ENST00000405260.1_Silent_p.V915V|PASK_ENST00000358649.4_Silent_p.V915V	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	915					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CCTGGAGCTCCACCCGCCTCA	0.587000													4	7					3.59834e-05	0.00343401	3.59834e-05	1	0
CACNA1S	779	broad.mit.edu	37	1	201047108	201047108	+	Silent	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:201047108G>A	ENST00000362061.3	-	11	1744	c.1518C>T	c.(1516-1518)agC>agT	p.S506S	CACNA1S_ENST00000367338.3_Silent_p.S506S	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	506					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCAGGATACCGCTACACACCA	0.577000													16	29					0	0	3.45872e-05	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525708	176525708	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:176525708G>A	ENST00000367662.3	+	2	1414	c.250G>A	c.(250-252)Gtg>Atg	p.V84M	PAPPA2_ENST00000367661.3_Missense_Mutation_p.V84M	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	84					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GCCCTACCCCGTGGGGGAGCA	0.562000													58	58					0	0	0.000147903	0	0
CIITA	4261	broad.mit.edu	37	16	11009480	11009480	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr16:11009480C>T	ENST00000324288.8	+	14	3075	c.2942C>T	c.(2941-2943)aCg>aTg	p.T981M	CIITA_ENST00000381835.5_Missense_Mutation_p.T397M	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	981			Missing (in BLS2).		interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						CGGATCCTCACGGCCTTTTCC	0.582000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								19	31					0	0	0.000229342	0	0
SON	6651	broad.mit.edu	37	21	34924690	34924690	+	Silent	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr21:34924690C>T	ENST00000356577.4	+	3	3628	c.3153C>T	c.(3151-3153)tcC>tcT	p.S1051S	SON_ENST00000300278.4_Silent_p.S1051S|SON_ENST00000290239.6_Silent_p.S1051S|SON_ENST00000381692.2_Intron|SON_ENST00000381679.4_Silent_p.S1051S	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	1051	14 X 6 AA repeats of [ED]-R-S-M-M-S.				anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						CTATGATGTCCCCTATGGCTG	0.498000													6	104					0	0	3.59834e-05	0	0
CROCCP2	84809	broad.mit.edu	37	1	16945760	16945760	+	RNA	SNP	A	A	G			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:16945760A>G	ENST00000412962.1	-	0	1759																											AAAAGGGCACAACGGCAGTCA	0.562000													3	13					0	0	2.17888e-05	0	0
FZD4	8322	broad.mit.edu	37	11	86662335	86662335	+	Missense_Mutation	SNP	C	C	T	rs80358298		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr11:86662335C>T	ENST00000531380.1	-	2	1768	c.1463G>A	c.(1462-1464)gGc>gAc	p.G488D	PRSS23_ENST00000533902.2_3'UTR|PRSS23_ENST00000531521.1_3'UTR	NM_012193.3	NP_036325.2	Q9ULV1	FZD4_HUMAN	frizzled family receptor 4	488			G -> D (in EVR1).		canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|negative regulation of cell-substrate adhesion|neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|progesterone secretion|regulation of vascular endothelial growth factor receptor signaling pathway|substrate adhesion-dependent cell spreading|vasculogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cell projection|cell surface|cytoplasm	cytokine binding|G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			breast(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(6)|skin(1)	21		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TGAAGTGATGCCCACCAACAA	0.403000													24	33					0	0	3.10358e-05	0	0
TBC1D15	64786	broad.mit.edu	37	12	72307690	72307690	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr12:72307690C>T	ENST00000550746.1	+	13	1500	c.1436C>T	c.(1435-1437)tCt>tTt	p.S479F	TBC1D15_ENST00000485960.2_Missense_Mutation_p.S462F|TBC1D15_ENST00000548679.1_3'UTR|TBC1D15_ENST00000319106.8_Missense_Mutation_p.S470F|TBC1D15_ENST00000393309.3_Missense_Mutation_p.S233F	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	479	Rab-GAP TBC.						protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGCTTTGCCTCTTACATGGAC	0.294000													587	623					0	0	0.000147903	0	0
EPHB1	2047	broad.mit.edu	37	3	134880946	134880946	+	Silent	SNP	G	G	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr3:134880946G>T	ENST00000398015.3	+	7	1879	c.1509G>T	c.(1507-1509)gtG>gtT	p.V503V	EPHB1_ENST00000493838.1_Silent_p.V64V	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	503	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TGGTATATGTGGTACAGGTGC	0.552000													40	12					1.03484e-13	1.07736e-11	0.000191422	1	0
CD163L1	283316	broad.mit.edu	37	12	7531757	7531757	+	Missense_Mutation	SNP	G	G	T	rs147841364		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr12:7531757G>T	ENST00000313599.3	-	9	2245	c.2188C>A	c.(2188-2190)Caa>Aaa	p.Q730K	CD163L1_ENST00000396630.1_Missense_Mutation_p.Q730K|CD163L1_ENST00000416109.2_Missense_Mutation_p.Q740K|CD163L1_ENST00000544331.1_Intron			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	730	SRCR 7.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CATTCAAGTTGCCTGCAAACA	0.488000													23	47					3.01185e-09	3.02559e-07	7.16444e-05	1	0
FRG1B	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V|FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													26	101					0	0	5.1965e-05	0	0
PTPRJ	5795	broad.mit.edu	37	11	48177618	48177618	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr11:48177618G>T	ENST00000418331.2	+	21	3737	c.3385G>T	c.(3385-3387)Gag>Tag	p.E1129*		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1129	Tyrosine-protein phosphatase.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TATGGTTTGGGAGAAAAATGT	0.328000													46	64					6.31075e-24	6.81799e-22	0.000147903	1	0
LGR5	8549	broad.mit.edu	37	12	71833953	71833953	+	Silent	SNP	G	G	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr12:71833953G>T	ENST00000266674.5	+	1	404	c.93G>T	c.(91-93)ctG>ctT	p.L31L	LGR5_ENST00000536515.1_Silent_p.L31L|TSPAN8_ENST00000393330.2_Intron|LGR5_ENST00000540815.2_Silent_p.L31L			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	31	LRRNT.					integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						GTGTGTTGCTGAGGGGCTGCC	0.667000													42	6582					2.17888e-05	0.00211462	2.17888e-05	1	0
LRRC14B	389257	broad.mit.edu	37	5	191738	191738	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr5:191738G>A	ENST00000328278.3	+	1	113	c.85G>A	c.(85-87)Gtg>Atg	p.V29M		NM_001080478.1	NP_001073947.1	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	29										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	10						CCTGGACAGCGTGGCCCACAA	0.652000													6	44					0	0	8.12818e-05	0	0
CNNM1	26507	broad.mit.edu	37	10	101090132	101090132	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr10:101090132G>A	ENST00000356713.4	+	1	1277	c.988G>A	c.(988-990)Gtg>Atg	p.V330M	CNNM1_ENST00000446890.1_Missense_Mutation_p.V259M|CNNM1_ENST00000370534.4_5'UTR|CNNM1_ENST00000370528.3_Missense_Mutation_p.V259M	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	330	DUF21.				ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		GCCGGCGCTCGTGTGCACCGG	0.697000													4	2					0	0	0.00024832	0	0
SSTR1	6751	broad.mit.edu	37	14	38679353	38679353	+	Silent	SNP	G	G	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr14:38679353G>T	ENST00000267377.2	+	3	1376	c.759G>T	c.(757-759)gtG>gtT	p.V253V		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	253					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	TGCGCATGGTGGCCCTCAAGG	0.567000													20	29					3.99206e-14	4.23306e-12	9.7654e-05	1	0
SLC35E3	55508	broad.mit.edu	37	12	69141725	69141725	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr12:69141725G>T	ENST00000398004.2	+	2	690	c.418G>T	c.(418-420)Ggt>Tgt	p.G140C		NM_018656.2	NP_061126.2	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E3	140						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			TATAACTTTAGGTGTAATCCT	0.328000													48	3158					5.01169e-05	0.00470442	5.01169e-05	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33658390	33658390	+	Silent	SNP	C	C	G			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr5:33658390C>G	ENST00000504830.1	-	7	1424	c.1089G>C	c.(1087-1089)ctG>ctC	p.L363L	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Silent_p.L363L	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	363	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						AAAGGTGAGACAGGCCCAGGG	0.502000										HNSCC(64;0.19)			53	146					0	0	0.000147903	0	0
MIA3	375056	broad.mit.edu	37	1	222803530	222803530	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:222803530G>A	ENST00000344922.5	+	4	2993	c.2968G>A	c.(2968-2970)Gca>Aca	p.A990T	MIA3_ENST00000344507.1_Intron|MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344441.6_Missense_Mutation_p.A990T	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	990					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		TCTGAGCATAGCAGAAAAAAT	0.413000													9	387					0	0	0.000151284	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971110	21971110	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr9:21971110T>C	ENST00000304494.5	-	2	518	c.248A>G	c.(247-249)cAc>cGc	p.H83R	CDKN2A_ENST00000578845.2_Missense_Mutation_p.H32R|CDKN2A_ENST00000498628.2_Missense_Mutation_p.H32R|CDKN2A_ENST00000579755.1_Silent_p.A97A|CDKN2A_ENST00000497750.1_Missense_Mutation_p.H32R|CDKN2A_ENST00000446177.1_Missense_Mutation_p.H83R|CDKN2A_ENST00000579122.1_Missense_Mutation_p.H83R|CDKN2A_ENST00000498124.1_Missense_Mutation_p.H83R|CDKN2A_ENST00000361570.3_Silent_p.A138A|CDKN2A_ENST00000530628.2_Silent_p.A97A|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000494262.1_Missense_Mutation_p.H32R|CDKN2A_ENST00000479692.2_Missense_Mutation_p.H32R	NM_000077.4	NP_000068.1	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	83			H -> N (in a lung tumor).|H -> Q (in dbSNP:rs34968276).|H -> Y (in a pancreas and a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.H83fs*2(2)|p.H83P(2)|p.V82fs*62(1)|p.0(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.D84fs*36(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)|p.V82_E88del(1)|p.H83R(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GGCAGCGTCGTGCACGGGTCG	0.741000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			64	7					0	0	0.000147903	0	0
CAPN5	726	broad.mit.edu	37	11	76834836	76834836	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr11:76834836C>T	ENST00000278559.3	+	13	2032	c.1843C>T	c.(1843-1845)Cga>Tga	p.R615*	CAPN5_ENST00000456580.2_Nonsense_Mutation_p.R655*|CAPN5_ENST00000531028.1_3'UTR|CAPN5_ENST00000529629.1_Nonsense_Mutation_p.R615*	NM_004055.4	NP_004046.2	O15484	CAN5_HUMAN	calpain 5	615	C2.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						CCTCCGGGACCGAAATAGCCG	0.622000													33	27					0	0	4.66903e-05	0	0
ISM2	145501	broad.mit.edu	37	14	77950804	77950804	+	Silent	SNP	A	A	C			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr14:77950804A>C	ENST00000393684.3	-	4	616	c.225T>G	c.(223-225)acT>acG	p.T75T	ISM2_ENST00000412904.1_Intron|ISM2_ENST00000429906.1_Silent_p.T82T|ISM2_ENST00000342219.4_Silent_p.T163T|ISM2_ENST00000493585.1_Silent_p.T163T			Q6H9L7	ISM2_HUMAN	isthmin 2	163						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						GCTCAGTGACAGTCCAACATC	0.617000													25	28					0	0	0.000117367	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778779	31778779	+	Missense_Mutation	SNP	C	C	T	rs142398035	byFrequency	TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr6:31778779C>T	ENST00000375654.4	-	2	1160	c.971G>A	c.(970-972)cGg>cAg	p.R324Q	HSPA1L_ENST00000417199.3_Missense_Mutation_p.R324Q	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	324					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						CTTGGCATCCCGAAGCGCTTT	0.498000													247	253					0	0	0.000147903	0	0
DNMBP	23268	broad.mit.edu	37	10	101716647	101716647	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr10:101716647G>A	ENST00000342239.3	-	4	675	c.584C>T	c.(583-585)cCa>cTa	p.P195L	DNMBP-AS1_ENST00000434409.1_RNA|DNMBP_ENST00000324109.4_Missense_Mutation_p.P195L			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	195	SH3 3.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		AAAACCTTCTGGAAAAATGCC	0.483000													24	42					0	0	9.22233e-05	0	0
FGFR3	2261	broad.mit.edu	37	4	1803642	1803642	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr4:1803642C>T	ENST00000340107.4	+	7	1076	c.820C>T	c.(820-822)Cac>Tac	p.H274Y	FGFR3_ENST00000352904.1_Missense_Mutation_p.H274Y|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000481110.2_Missense_Mutation_p.H274Y|FGFR3_ENST00000260795.2_Missense_Mutation_p.H274Y|FGFR3_ENST00000440486.2_Missense_Mutation_p.H274Y|FGFR3_ENST00000412135.2_Missense_Mutation_p.H274Y	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	274	Ig-like C2-type 3.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CGTGGAGTTCCACTGCAAGGT	0.672000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				143	173					0	0	0.000147903	0	0
PLP1	5354	broad.mit.edu	37	X	103044323	103044323	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chrX:103044323C>T	ENST00000418604.1	+	7	1038	c.758C>T	c.(757-759)tCc>tTc	p.S253F	PLP1_ENST00000303958.2_Missense_Mutation_p.S253F|PLP1_ENST00000466486.1_3'UTR|PLP1_ENST00000361621.2_Missense_Mutation_p.S218F	NM_001128834.1	NP_001122306.1	P60201	MYPR_HUMAN	proteolipid protein 1	253			S -> F (in HLD1).		cell death|synaptic transmission	integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	17						ACACTGGTTTCCCTGGTGAGT	0.453000													59	4					0	0	0.000147903	0	0
PRKDC	5591	broad.mit.edu	37	8	48749816	48749816	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr8:48749816G>A	ENST00000314191.2	-	58	7771	c.7715C>T	c.(7714-7716)cCa>cTa	p.P2572L	PRKDC_ENST00000338368.3_Missense_Mutation_p.P2572L|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2573	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CATGGGGTTTGGATAATCTGG	0.388000								Non-homologous end-joining					13	12					0	0	7.07596e-05	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144859894	144859894	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:144859894C>T	ENST00000369359.4	-	41	6636	c.6598G>A	c.(6598-6600)Ggg>Agg	p.G2200R	PDE4DIP_ENST00000313382.9_Missense_Mutation_p.G1958R|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.G2064R|RP4-791M13.4_ENST00000532137.1_RNA|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.G2064R|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.G2149R			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2064					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAATTGTTCCCCTGAATGCTC	0.592000			T	PDGFRB	MPD								19	71					0	0	0.000132079	0	0
FIGLA	344018	broad.mit.edu	37	2	71012684	71012684	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr2:71012684G>A	ENST00000332372.6	-	3	476	c.472C>T	c.(472-474)Caa>Taa	p.Q158*		NM_001004311.3	NP_001004311.2	Q6QHK4	FIGLA_HUMAN	folliculogenesis specific basic helix-loop-helix	158					multicellular organismal development|oocyte development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcription factor complex	DNA binding|transcription factor binding			endometrium(2)|lung(3)	5						CTGATATGTTGGGTGATGTTT	0.488000													82	207					0	0	0.000147903	0	0
TTC12	54970	broad.mit.edu	37	11	113196260	113196260	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr11:113196260G>C	ENST00000393020.1	+	6	742	c.337G>C	c.(337-339)Ggg>Cgg	p.G113R	TTC12_ENST00000483239.2_Missense_Mutation_p.G113R|TTC12_ENST00000529221.1_Missense_Mutation_p.G113R|TTC12_ENST00000314756.3_Missense_Mutation_p.G113R			Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	113							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		AAAAGAAAAAGGGAATGAAGC	0.428000													17	25					0	0	9.7654e-05	0	0
ZNF398	57541	broad.mit.edu	37	7	148876793	148876793	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr7:148876793C>T	ENST00000420008.2	+	6	2104	c.1316C>T	c.(1315-1317)cCc>cTc	p.P439L	ZNF398_ENST00000483892.1_Missense_Mutation_p.P439L|ZNF398_ENST00000491174.1_Missense_Mutation_p.P439L|ZNF398_ENST00000335901.4_Missense_Mutation_p.P439L|ZNF398_ENST00000540950.1_Missense_Mutation_p.P615L|ZNF398_ENST00000426851.2_Missense_Mutation_p.P439L|ZNF398_ENST00000475153.1_Missense_Mutation_p.P610L	NM_170686.2	NP_733787.1	Q8TD17	ZN398_HUMAN	zinc finger protein 398	610					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)	25	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			CCACCAGGTCCCCTCATAACT	0.557000													9	29					0	0	1.12685e-05	0	0
RGS7BP	401190	broad.mit.edu	37	5	63803626	63803626	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr5:63803626G>A	ENST00000334025.2	+	2	580	c.254G>A	c.(253-255)cGg>cAg	p.R85Q	RGS7BP_ENST00000508162.1_Intron	NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein	85					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		CCCTCACTCCGGGCGGAAATG	0.522000													17	25					0	0	5.01169e-05	0	0
CSMD1	64478	broad.mit.edu	37	8	2815274	2815274	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr8:2815274G>A	ENST00000520002.1	-	64	10316	c.9761C>T	c.(9760-9762)aCg>aTg	p.T3254M	CSMD1_ENST00000537824.1_Missense_Mutation_p.T3253M|CSMD1_ENST00000602723.1_Missense_Mutation_p.T3077M|CSMD1_ENST00000602557.1_Missense_Mutation_p.T3254M|CSMD1_ENST00000400186.3_Missense_Mutation_p.T3077M|CSMD1_ENST00000542608.1_Missense_Mutation_p.T3076M			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3254	Sushi 27.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGTGCGAGTCGTGGAACCTTG	0.443000													5	4					0	0	3.59834e-05	0	0
KIAA0319L	79932	broad.mit.edu	37	1	35913788	35913788	+	Silent	SNP	C	C	T	rs147017356		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:35913788C>T	ENST00000325722.3	-	16	2733	c.2499G>A	c.(2497-2499)ccG>ccA	p.P833P	KIAA0319L_ENST00000373266.4_Silent_p.P270P|KIAA0319L_ENST00000485551.1_5'UTR	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	833						cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GCTCCGTGTACGGCTGAATCT	0.542000													25	91					0	0	9.22233e-05	0	0
SPTA1	6708	broad.mit.edu	37	1	158606503	158606503	+	Silent	SNP	C	C	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:158606503C>T	ENST00000368148.3	-	37	5418	c.5238G>A	c.(5236-5238)caG>caA	p.Q1746Q	SPTA1_ENST00000368147.3_Silent_p.Q1746Q	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1746					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCTGAACCCCCTGAAGATCTC	0.468000													25	129					0	0	7.16444e-05	0	0
PRKCH	5583	broad.mit.edu	37	14	61788891	61788891	+	Silent	SNP	C	C	G			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr14:61788891C>G	ENST00000332981.5	+	1	457	c.72C>G	c.(70-72)ccC>ccG	p.P24P	RP11-902B17.1_ENST00000500036.2_RNA	NM_006255.3	NP_006246.2	P24723	KPCL_HUMAN	protein kinase C, eta	24	C2.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		GGCTGCAGCCCACCCGCTGGT	0.682000													3	7					0	0	6.4e-05	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87370861	87370861	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr7:87370861A>C	ENST00000338056.3	+	7	1057	c.646A>C	c.(646-648)Ata>Cta	p.I216L	RUNDC3B_ENST00000496000.1_3'UTR|RUNDC3B_ENST00000493037.1_Missense_Mutation_p.I199L|RUNDC3B_ENST00000394654.3_Missense_Mutation_p.I199L	NM_001134405.1|NM_138290.2	NP_001127877.1|NP_612147.1	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B	216										breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(2)	26	Esophageal squamous(14;0.00164)					TCCTGCTGTAATAGACTATAC	0.279000													19	18					0	0	5.49717e-05	0	0
PCSK9	255738	broad.mit.edu	37	1	55505557	55505557	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:55505557T>C	ENST00000302118.5	+	1	337	c.47T>C	c.(46-48)cTg>cCg	p.L16P	PCSK9_ENST00000452118.2_Missense_Mutation_p.L16P	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	16					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						ctgccactgctgctgctgctg	0.706000													49	43					0	0	0.000147903	0	0
CAMK2B	816	broad.mit.edu	37	7	44266164	44266164	+	Silent	SNP	C	C	G			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr7:44266164C>G	ENST00000395749.2	-	20	1624	c.1548G>C	c.(1546-1548)ggG>ggC	p.G516G	CAMK2B_ENST00000346990.4_Intron|CAMK2B_ENST00000347193.4_Intron|CAMK2B_ENST00000457475.1_Intron|CAMK2B_ENST00000440254.2_Intron|CAMK2B_ENST00000358707.3_Intron|CAMK2B_ENST00000353625.4_Intron|CAMK2B_ENST00000395747.2_Intron|CAMK2B_ENST00000258682.6_Intron|CAMK2B_ENST00000350811.3_Intron|CAMK2B_ENST00000502837.2_Intron|CAMK2B_ENST00000489429.1_5'UTR	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	516					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						AGGGCGGGGGCCCCACTGGCG	0.697000													3	8					0	0	0.00024832	0	0
HNRNPR	10236	broad.mit.edu	37	1	23648071	23648071	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr1:23648071G>T	ENST00000478691.1	-	6	729	c.458C>A	c.(457-459)cCg>cAg	p.P153Q	HNRNPR_ENST00000426846.2_Missense_Mutation_p.P94Q|HNRNPR_ENST00000374616.3_Missense_Mutation_p.P254Q|HNRNPR_ENST00000427764.2_Missense_Mutation_p.P216Q|HNRNPR_ENST00000302271.6_Missense_Mutation_p.P254Q|HNRNPR_ENST00000374612.1_Missense_Mutation_p.P254Q|HNRNPR_ENST00000606561.1_Missense_Mutation_p.P115Q	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	254	Asp/Glu-rich (acidic).					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		CTTATTCTTCGGAATGGATCC	0.343000													14	1213					6.40141e-05	0.00591201	6.40141e-05	1	0
LBX2	85474	broad.mit.edu	37	2	74729892	74729892	+	Missense_Mutation	SNP	G	G	A	rs149381878		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr2:74729892G>A	ENST00000460508.3	-	1	551	c.95C>T	c.(94-96)tCc>tTc	p.S32F	LBX2_ENST00000550249.1_Intron|LBX2_ENST00000341396.2_Intron|LBX2-AS1_ENST00000603175.1_RNA|LBX2-AS1_ENST00000548978.2_RNA	NM_001009812.1	NP_001009812.1	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	30						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(1)	4						TGCGGGCCGGGAAGCAGCCAG	0.627000													20	37					0	0	0.000229342	0	0
DLX6	1750	broad.mit.edu	37	7	96635389	96635391	+	In_Frame_Del	DEL	CAG	CAG	-	rs35478952		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr7:96635389_96635391delCAG	ENST00000518156.2	+	1	530_532	c.100_102delCAG	c.(100-102)del	p.Q44del	DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000430027.2_RNA|DLX6-AS1_ENST00000437541.1_RNA|DLX6_ENST00000007660.5_Intron|DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000437331.2_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					gcagcagcaacagcagcagcagc	0.680													2	4	---	---	---	---					
RP11-34D15.2	0	broad.mit.edu	37	10	102104601	102104601	+	RNA	DEL	T	T	-			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr10:102104601delT	ENST00000429420.1	-	0	103																											AAAATCACAAttttttttttt	0.403													3	6	---	---	---	---					
OVOS2	144203	broad.mit.edu	37	12	31269189	31269190	+	RNA	INS	-	-	ATCAT	rs35880498		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr12:31269189_31269190insATCAT	ENST00000542490.1	-	0	165																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CATGAGAACTCATTACCATGAT	0.351													2	4	---	---	---	---					
YY1	7528	broad.mit.edu	37	14	100728792	100728792	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr14:100728792delA	ENST00000262238.4	+	2	1091	c.831delA	c.(829-831)gcfs	p.A277fs		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	277	Involved in nuclear matrix association.				cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				AACAACTGGCAGAATTTGCTA	0.398													47	57	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-516)gaafs	p.E172fs	IL32_ENST00000548476.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000440815.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.E132fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.E163fs|IL32_ENST00000534507.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.E162fs|IL32_ENST00000552936.1_Frame_Shift_Ins_p.E196fs|IL32_ENST00000526464.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.E152fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.E209fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000382213.3_Frame_Shift_Ins_p.E163fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.E218fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.E172fs|IL32_ENST00000530890.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.E115fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.E172fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													11	223	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	112402	112405	+	RNA	DEL	AACC	AACC	-	rs113232824		TCGA-D9-A1X3-01A-11D-A197-08	TCGA-D9-A1X3-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	453504ec-ec7a-481c-b5d5-e32c27caede6	2ac41d53-16d3-4125-9a1f-36e88e4567d7	g.chr18:112402_112405delAACC	ENST00000576266.1	+	0	36_39																											CCCTGCCCCGAACCACCCGACCCC	0.711													3	4	---	---	---	---