Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR2L2	26246	broad.mit.edu	37	1	248202232	248202232	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:248202232C>T	ENST00000366479.2	+	1	759	c.663C>T	c.(661-663)ctC>ctT	p.L221L	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GCCGGGTTCTCCTTGCTGTCT	0.502000													30	227					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163051225	163051225	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:163051225C>T	ENST00000188790.4	-	17	1643	c.1436G>A	c.(1435-1437)gGa>gAa	p.G479E	FAP_ENST00000443424.1_Missense_Mutation_p.G454E	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	479					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						ATCAGTGCGTCCATCATGAAG	0.448000													27	44					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70546218	70546218	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:70546218C>T	ENST00000323786.5	-	5	683	c.662G>A	c.(661-663)cGc>cAc	p.R221H	COG4_ENST00000393612.4_Missense_Mutation_p.R217H|COG4_ENST00000564653.1_Missense_Mutation_p.A179T	NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	217					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				CTTGAAGAAGCGCTCCACCTG	0.512000													21	40					0	0	1	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60345065	60345065	+	RNA	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:60345065C>T	ENST00000581291.1	-	0	902																				breast(2)|kidney(1)|lung(2)	5						CCCCATCAATCAATATCCGGA	0.597000													28	22					0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30128290	30128290	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:30128290G>A	ENST00000484663.1	-	6	1733	c.600C>T	c.(598-600)aaC>aaT	p.N200N	MAPK3_ENST00000403394.1_Silent_p.N314N|MAPK3_ENST00000395199.3_Silent_p.N314N|MAPK3_ENST00000395200.1_Silent_p.N246N|MAPK3_ENST00000395202.1_Silent_p.N270N|MAPK3_ENST00000322266.5_Silent_p.N270N|MAPK3_ENST00000263025.4_Silent_p.N314N			P27361	MK03_HUMAN	mitogen-activated protein kinase 3	314	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	GTTTATTGGGGTTAAAGGTTA	0.582000													60	143					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615543	179615543	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:179615543C>T	ENST00000360870.5	-	46	11806	c.11584G>A	c.(11584-11586)Gag>Aag	p.E3862K	TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9694							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATACTTCCTCCTTCTCACAT	0.373000													45	27					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66070837	66070837	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:66070837C>T	ENST00000349533.6	+	11	1705	c.1520C>T	c.(1519-1521)tCt>tTt	p.S507F	LEPR_ENST00000371060.3_Missense_Mutation_p.S507F|LEPR_ENST00000371058.1_Missense_Mutation_p.S507F|LEPR_ENST00000371059.3_Missense_Mutation_p.S507F|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000344610.8_Missense_Mutation_p.S507F	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	507					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTCCTATTATCTGGCTACACA	0.413000													25	77					0	0	1	0	0
DIO2	1734	broad.mit.edu	37	14	80669111	80669111	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:80669111G>A	ENST00000557010.1	-	4	1128	c.743C>T	c.(742-744)tCc>tTc	p.S248F	DIO2_ENST00000557125.1_3'UTR|DIO2_ENST00000555750.1_Missense_Mutation_p.S284F|DIO2_ENST00000438257.4_Missense_Mutation_p.S248F|DIO2_ENST00000422005.3_3'UTR	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	248					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		AAGGTTGTAGGAGAAGGGGCC	0.438000													14	24					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100841659	100841659	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:100841659C>T	ENST00000369208.3	-	11	2056	c.1274G>A	c.(1273-1275)aGg>aAg	p.R425K	SIM1_ENST00000262901.4_Missense_Mutation_p.R425K			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	425	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		GGAGCCAGGCCTATCGGCGGG	0.597000													10	51					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47765657	47765657	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:47765657G>A	ENST00000360380.3	-	7	984	c.621C>T	c.(619-621)atC>atT	p.I207I	STIL_ENST00000396221.2_Silent_p.I207I|STIL_ENST00000337817.5_Silent_p.I207I|STIL_ENST00000243182.6_Silent_p.I207I|STIL_ENST00000371877.3_Silent_p.I207I			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	207					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GAATAATGGGGATGGGCTTCA	0.388000													18	56					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116061163	116061163	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:116061163G>A	ENST00000369271.3	-	13	1792	c.1492C>T	c.(1492-1494)Cgc>Tgc	p.R498C	AFAP1L2_ENST00000304129.4_Missense_Mutation_p.R498C|AFAP1L2_ENST00000491814.1_5'UTR|AFAP1L2_ENST00000545353.1_Missense_Mutation_p.R551C	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	498					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TCCTCCTGGCGGTCCTGGCTA	0.617000													22	19					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113238118	113238118	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:113238118C>T	ENST00000369644.1	+	12	2562	c.1533C>T	c.(1531-1533)ctC>ctT	p.L511L	MOV10_ENST00000413052.2_Silent_p.L567L|MOV10_ENST00000357443.2_Silent_p.L567L|MOV10_ENST00000369645.1_Silent_p.L567L|RP11-426L16.3_ENST00000421943.1_RNA|MOV10_ENST00000468624.1_3'UTR			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	567					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		GTCAAAGGCTCCGGGTCCACC	0.592000													11	46					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14312829	14312829	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:14312829C>T	ENST00000571589.1	+	8	839	c.667C>T	c.(667-669)Cct>Tct	p.P223S	MKL2_ENST00000574045.1_Missense_Mutation_p.P223S|MKL2_ENST00000318282.5_Missense_Mutation_p.P223S|MKL2_ENST00000341243.5_Missense_Mutation_p.P212S|MKL2_ENST00000573051.1_Missense_Mutation_p.P172S|MKL2_ENST00000572567.1_Missense_Mutation_p.P212S	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	212					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ATCGCCATCTCCTGTGACTAC	0.463000													4	48					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82188651	82188651	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:82188651C>T	ENST00000376520.4	+	2	921	c.93C>T	c.(91-93)tcC>tcT	p.S31S	TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376544.3_Silent_p.S31S|TLE4_ENST00000376552.2_Silent_p.S31S|TLE4_ENST00000265284.6_Silent_p.S31S|TLE4_ENST00000376537.4_Silent_p.S31S			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TTTCCGAATCCTGTGATCGGA	0.413000													12	8					0	0	1	0	0
SLC6A7	6534	broad.mit.edu	37	5	149583589	149583589	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:149583589C>T	ENST00000230671.2	+	10	1691	c.1320C>T	c.(1318-1320)atC>atT	p.I440I	SLC6A7_ENST00000524041.1_Silent_p.I440I	NM_014228.3	NP_055043.2	Q99884	SC6A7_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 7	440						integral to plasma membrane|membrane fraction	neurotransmitter:sodium symporter activity|proline:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(1)|stomach(1)	16		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Proline(DB00172)	TGGGGCTGATCCTCACCACTG	0.597000													9	14					0	0	1	0	0
IFT88	8100	broad.mit.edu	37	13	21265292	21265292	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr13:21265292G>A	ENST00000319980.6	+	28	2807	c.2480G>A	c.(2479-2481)gGa>gAa	p.G827E	IFT88_ENST00000537103.1_Missense_Mutation_p.G799E|IFT88_ENST00000382778.4_3'UTR|IFT88_ENST00000351808.5_Missense_Mutation_p.G818E	NM_175605.3	NP_783195.2	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)	827					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		GAAGAATTAGGAGATGATTTG	0.363000													21	13					0	0	1	0	0
CEP89	84902	broad.mit.edu	37	19	33372865	33372865	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:33372865C>A	ENST00000305768.4	-	18	2108	c.2020G>T	c.(2020-2022)Gag>Tag	p.E674*		NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	674						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						TCCTGCTGCTCCAGCAGACGG	0.637000													5	8					0.000602214	0.000604706	1	1	0
OR52N1	79473	broad.mit.edu	37	11	5809341	5809341	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:5809341G>A	ENST00000317078.1	-	1	705	c.706C>T	c.(706-708)Cga>Tga	p.R236*	TRIM5_ENST00000380027.1_Intron	NM_001001913.1	NP_001001913.1	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N, member 1	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(15)|prostate(2)|skin(3)	31		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GCCTTCTGTCGAGCATCTGCT	0.478000													52	20					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77147264	77147264	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:77147264C>G	ENST00000461745.1	+	2	1061	c.161C>G	c.(160-162)gCg>gGg	p.A54G	ROBO2_ENST00000487694.3_Missense_Mutation_p.A70G|ROBO2_ENST00000332191.8_Missense_Mutation_p.A54G	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	54	Ig-like C2-type 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AACTGCAAGGCGGAGGGCCGG	0.617000													9	44					0	0	1	0	0
MTMR6	9107	broad.mit.edu	37	13	25832756	25832756	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr13:25832756C>T	ENST00000381801.5	-	7	1562	c.801G>A	c.(799-801)caG>caA	p.Q267Q	MTMR6_ENST00000540661.1_Silent_p.Q267Q	NM_004685.3	NP_004676.3	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	267	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(5)|stomach(3)	36		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TTCCAACAAACTGAAATCTAA	0.318000													13	11					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													4	64					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51747199	51747199	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:51747199C>T	ENST00000395052.3	+	3	1395	c.1161C>T	c.(1159-1161)gcC>gcT	p.A387A	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Silent_p.A387A	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	387					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CAGTGTACGCCATGGCCCATG	0.632000													32	31					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058343	11058343	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr21:11058343G>A	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAAAGGAGAGAAATCTCTTT	0.353000													6	90					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123725050	123725050	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:123725050G>A	ENST00000223642.1	-	36	4432	c.4403C>T	c.(4402-4404)cCc>cTc	p.P1468L		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1468					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	ATCACTGGAGGGAATCTGTTT	0.343000													49	92					0	0	1	0	0
PHGDH	26227	broad.mit.edu	37	1	120263838	120263838	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:120263838G>A	ENST00000369407.3	+	1	1589	c.82G>A	c.(82-84)Gat>Aat	p.D28N	PHGDH_ENST00000369409.4_Missense_Mutation_p.D62N			O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	62					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	18	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	GGTGACCGCTGATGTCATCAA	0.522000													26	104					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223284364	223284364	+	Silent	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:223284364A>G	ENST00000540964.1	-	4	2471	c.2010T>C	c.(2008-2010)tgT>tgC	p.C670C	TLR5_ENST00000342210.6_Silent_p.C670C			O60602	TLR5_HUMAN	toll-like receptor 5	670			Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		CTGTCTTATAACAGATAAAAC	0.458000													15	73					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	782347	782347	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:782347C>T	ENST00000540986.1	-	7	1979	c.544G>A	c.(544-546)Gag>Aag	p.E182K	NARFL_ENST00000301694.5_3'UTR|NARFL_ENST00000562862.1_5'UTR|NARFL_ENST00000251588.2_Missense_Mutation_p.E284K|NARFL_ENST00000568545.1_Missense_Mutation_p.E182K			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	284					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				GAGACGCCCTCTTCCTCCAGC	0.537000													73	168					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18747456	18747456	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:18747456C>T	ENST00000433979.1	+	29	4033	c.3917C>T	c.(3916-3918)tCt>tTt	p.S1306F	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.S1347F|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.S1306F	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1306	PX.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.S1306Y(1)		breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				TTTTTCCTCTCTGAGGCTGTG	0.289000													11	27					0	0	1	0	0
CCDC25	55246	broad.mit.edu	37	8	27614250	27614250	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:27614250G>A	ENST00000356537.4	-	4	247	c.154C>T	c.(154-156)Ctt>Ttt	p.L52F	CCDC25_ENST00000522915.1_Intron|CCDC25_ENST00000539095.1_Intron	NM_018246.2	NP_060716.2	Q86WR0	CCD25_HUMAN	coiled-coil domain containing 25	52										endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	7		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0223)|KIRC - Kidney renal clear cell carcinoma(542;0.11)|Kidney(114;0.131)|Colorectal(74;0.154)		TGTAATCGAAGGTATACATGA	0.363000													16	14					0	0	1	0	0
STARD6	147323	broad.mit.edu	37	18	51855780	51855780	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:51855780G>A	ENST00000581310.1	-	8	789	c.416C>T	c.(415-417)cCa>cTa	p.P139L	STARD6_ENST00000580990.2_Intron|STARD6_ENST00000307844.3_Missense_Mutation_p.P139L			P59095	STAR6_HUMAN	StAR-related lipid transfer (START) domain containing 6	139	START.				lipid transport		lipid binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)	8				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		ATTTGAAGATGGAGGATATTC	0.318000													86	58					0	0	1	0	0
CHRNA5	1138	broad.mit.edu	37	15	78882151	78882151	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:78882151G>A	ENST00000299565.5	+	5	618	c.418G>A	c.(418-420)Gat>Aat	p.D140N	CHRNA5_ENST00000559554.1_Missense_Mutation_p.D140N|RP11-650L12.2_ENST00000567141.1_RNA	NM_000745.3	NP_000736.2	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5 (neuronal)	140					behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)|skin(3)	15						TTTTAGTGCAGATGGACGTTT	0.373000													18	27					0	0	1	0	0
SNRNP40	9410	broad.mit.edu	37	1	31769575	31769575	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:31769575C>T	ENST00000263694.4	-	1	42	c.24G>A	c.(22-24)aaG>aaA	p.K8K	SNRNP40_ENST00000446633.2_Silent_p.K8K	NM_004814.2	NP_004805.2	Q96DI7	SNR40_HUMAN	small nuclear ribonucleoprotein 40kDa (U5)	8						catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	7						ACTCTGGGCCCTTACGCTTCT	0.652000													40	42					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117303092	117303092	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:117303092G>A	ENST00000369478.3	+	3	559	c.451G>A	c.(451-453)Gga>Aga	p.G151R		NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	151	Ig-like C2-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GGTAATGAATGGAACTGACCC	0.408000													29	42					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96447945	96447945	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:96447945G>A	ENST00000285979.6	+	3	594	c.395G>A	c.(394-396)cGg>cAg	p.R132Q	CYP2C18_ENST00000339022.5_Missense_Mutation_p.R132Q|CYP2C19_ENST00000464755.1_3'UTR	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		ATGACTCTGCGGAATTTTGGG	0.498000													33	24					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4968181	4968181	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:4968181G>A	ENST00000380373.2	-	1	175	c.150C>T	c.(148-150)atC>atT	p.I50I	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTCTTGATGATAAAAAGAA	0.438000													14	36					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098863	11098863	+	RNA	SNP	A	A	G	rs75318310	by1000genomes	TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr21:11098863A>G	ENST00000470054.1	-	0	62									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccagcctccaactcccccttc	0.627000													9	26					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19924175	19924175	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:19924175G>A	ENST00000295824.9	-	12	2356	c.2195C>T	c.(2194-2196)cCc>cTc	p.P732L	EFHB_ENST00000344838.4_Missense_Mutation_p.P602L	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	732					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						ACGAATTCGGGGAGCAGGAAT	0.418000													19	12					0	0	1	0	0
FBXO39	162517	broad.mit.edu	37	17	6683757	6683757	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:6683757G>A	ENST00000321535.4	+	2	700	c.570G>A	c.(568-570)agG>agA	p.R190R		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	190										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						GCTACATGAGGAATGAGAATG	0.493000													34	59					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212391	26212391	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:26212391C>T	ENST00000379034.1	+	2	577	c.428C>T	c.(427-429)tCc>tTc	p.S143F		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	143	Ser-rich.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						CATGATGTCTCCGTTCCTCAG	0.527000													43	33					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134154611	134154611	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:134154611C>T	ENST00000452510.2	+	21	3052	c.2894C>T	c.(2893-2895)gCc>gTc	p.A965V	DDX46_ENST00000354283.4_Missense_Mutation_p.A964V	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	964					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TACTCTGAAGCCGCAATTACA	0.413000													14	19					0	0	1	0	0
GBAP1	2630	broad.mit.edu	37	1	155188246	155188246	+	RNA	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:155188246C>T	ENST00000486869.1	-	0	120					NR_002188.2																						ATGATGCTTACCCTACCCGAA	0.557000													50	226					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33338182	33338182	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:33338182G>A	ENST00000374796.2	-	10	4386	c.1816C>T	c.(1816-1818)Ctc>Ttc	p.L606F	NCOA6_ENST00000359003.2_Missense_Mutation_p.L606F			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	606	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						ATGTTGCTGAGGTTCACTTGA	0.582000													8	84					0	0	1	0	0
SAT2	112483	broad.mit.edu	37	17	7530945	7530945	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:7530945G>A	ENST00000269298.5	-	1	228	c.9C>T	c.(7-9)tcC>tcT	p.S3S	SHBG_ENST00000574539.1_Intron|SHBG_ENST00000575314.1_Intron|SHBG_ENST00000576478.1_Intron|SHBG_ENST00000572262.1_Intron|SHBG_ENST00000570547.1_Intron|SHBG_ENST00000576728.1_Intron|SAT2_ENST00000380466.2_5'UTR|SHBG_ENST00000572182.1_Intron|SAT2_ENST00000573566.1_Silent_p.S3S	NM_133491.3	NP_597998.1	Q96F10	SAT2_HUMAN	spermidine/spermine N1-acetyltransferase family member 2	3						cytoplasm	diamine N-acetyltransferase activity	p.?(1)		kidney(1)|large_intestine(2)	3				READ - Rectum adenocarcinoma(115;0.166)	Spermine(DB00127)	GGATCCGCACGGAAGCCATCC	0.622000													32	33					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10398350	10398350	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:10398350C>T	ENST00000226207.5	-	37	5458	c.5364G>A	c.(5362-5364)aaG>aaA	p.K1788K	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1788						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GTTCCAGGTTCTTCTTCATCC	0.542000													47	137					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40483533	40483533	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:40483533G>A	ENST00000264657.5	-	11	1378	c.1066C>T	c.(1066-1068)Cct>Tct	p.P356S	STAT3_ENST00000389272.3_Missense_Mutation_p.P258S|STAT3_ENST00000404395.3_Missense_Mutation_p.P356S|STAT3_ENST00000588969.1_Missense_Mutation_p.P356S|STAT3_ENST00000585517.1_Missense_Mutation_p.P356S	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	356					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TTCAACTCAGGGAATTTGACC	0.303000									Hyperimmunoglobulin E Recurrent Infection Syndrome				6	17					0	0	1	0	0
AFTPH	54812	broad.mit.edu	37	2	64779312	64779312	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:64779312C>T	ENST00000422803.1	+	2	1018	c.704C>T	c.(703-705)gCc>gTc	p.A235V	AFTPH_ENST00000238856.4_Missense_Mutation_p.A235V|AFTPH_ENST00000238855.7_Missense_Mutation_p.A235V|AFTPH_ENST00000409933.1_Missense_Mutation_p.A235V			Q6ULP2	AFTIN_HUMAN	aftiphilin	235					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						GCAGATTTTGCCACATTTTCC	0.358000													15	39					0	0	1	0	0
TRPV1	7442	broad.mit.edu	37	17	3477143	3477143	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:3477143G>A	ENST00000174621.6	-	12	2170	c.1881C>T	c.(1879-1881)aaC>aaT	p.N627N	TRPV1_ENST00000310522.5_Silent_p.N569N|TRPV1_ENST00000399756.4_Silent_p.N629N|TRPV1_ENST00000571088.1_Silent_p.N629N|TRPV1_ENST00000399759.3_Silent_p.N629N|SHPK_ENST00000572705.1_Silent_p.N629N|TRPV1_ENST00000425167.2_Silent_p.N640N|TRPV1_ENST00000576351.1_Silent_p.N619N			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	629					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	AGTACAGGCTGTTGTAGGAGC	0.582000													6	65					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038181	75038181	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:75038181C>T	ENST00000326665.5	-	14	3431	c.3213G>A	c.(3211-3213)agG>agA	p.R1071R	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1071	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AGTCAGTTTTCCTCAGAGATG	0.408000													65	81					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55961115	55961115	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:55961115C>T	ENST00000263923.4	-	21	3120	c.2825G>A	c.(2824-2826)gGg>gAg	p.G942E		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	942	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GAATCGTGCCCCTTTGGTCTA	0.428000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			10	53					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34189815	34189815	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:34189815C>T	ENST00000373381.4	-	19	3159	c.2983G>A	c.(2983-2985)Gaa>Aaa	p.E995K		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	955	CUB 6.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGAGATGTTTCGATAATCCAG	0.527000													16	57					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51918195	51918195	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:51918195C>T	ENST00000356298.5	-	8	1614	c.1498G>A	c.(1498-1500)Ggg>Agg	p.G500R	SIGLEC10_ENST00000436984.2_Intron|SIGLEC10_ENST00000353836.5_Intron|CTD-2616J11.3_ENST00000532473.1_RNA|SIGLEC10_ENST00000525998.1_Intron|SIGLEC10_ENST00000442846.3_Intron|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.G500R|SIGLEC10_ENST00000441969.3_Intron|SIGLEC10_ENST00000432469.2_Intron|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.G442R	NM_033130.4	NP_149121.2	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	500					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GCCCAGGGCCCGGCTGAGCTG	0.701000													32	37					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735748	140735748	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140735748C>T	ENST00000571252.1	+	1	981	c.981C>T	c.(979-981)ctC>ctT	p.L327L	PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCTGGTCTCCGAGCTAGAA	0.458000													3	5					0	0	1	0	0
CCNJ	54619	broad.mit.edu	37	10	97810058	97810058	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:97810058C>T	ENST00000265992.5	+	3	482	c.115C>T	c.(115-117)Ctc>Ttc	p.L39F	ENTPD1-AS1_ENST00000416301.1_RNA|CCNJ_ENST00000403870.3_Missense_Mutation_p.L39F|ENTPD1-AS1_ENST00000452728.1_RNA|ENTPD1-AS1_ENST00000458228.1_RNA|ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1-AS1_ENST00000454638.1_RNA|CCNJ_ENST00000465148.2_Missense_Mutation_p.L39F|CCNJ_ENST00000534974.1_Missense_Mutation_p.L39F|ENTPD1-AS1_ENST00000427846.1_RNA	NM_001134375.1|NM_001134376.1|NM_019084.4	NP_001127847.1|NP_001127848.1|NP_061957.2	Q5T5M9	CCNJ_HUMAN	cyclin J	39	Cyclin N-terminal.					nucleus				breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	11				Epithelial(162;6.1e-08)|all cancers(201;2.32e-06)		TCAGTTAAGTCTCAGACGGTA	0.468000													21	27					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	32014353	32014353	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:32014353C>T	ENST00000432498.1	+	32	3978	c.3585C>T	c.(3583-3585)ccC>ccT	p.P1195P	SFI1_ENST00000400289.1_Silent_p.P1144P|SFI1_ENST00000540643.1_Silent_p.P1171P|SFI1_ENST00000414585.1_3'UTR|SFI1_ENST00000474741.1_3'UTR|SFI1_ENST00000400288.2_Silent_p.P1226P|SFI1_ENST00000443326.1_Silent_p.P1144P|SFI1_ENST00000443011.1_Silent_p.P1073P	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	1226					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						AGCGCCAGCCCATTGGCGCCT	0.692000													12	38					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46136371	46136371	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:46136371C>T	ENST00000252934.5	+	9	1391	c.1126C>T	c.(1126-1128)Cgt>Tgt	p.R376C	ATXN10_ENST00000381061.4_Missense_Mutation_p.R312C	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	376					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		TCATCTCATTCGTCTGATTGG	0.368000													25	97					0	0	1	0	0
CRHR1	1394	broad.mit.edu	37	17	43908262	43908262	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:43908262C>T	ENST00000314537.5	+	8	951	c.726C>T	c.(724-726)atC>atT	p.I242I	CRHR1_ENST00000339069.5_Silent_p.I141I|CRHR1_ENST00000398285.3_Silent_p.I271I|CRHR1_ENST00000352855.5_Silent_p.I202I|CRHR1_ENST00000577353.1_Silent_p.I242I|CRHR1_ENST00000293493.7_Silent_p.I67I	NM_001145147.1|NM_001145148.1|NM_004382.4	NP_001138619.1|NP_001138620.1|NP_004373.2	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	271					female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(15)|pancreas(1)|skin(1)	24	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		CCTTCCCCATCATTGTGGCCT	0.607000													13	49					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394337	164394337	+	Missense_Mutation	SNP	C	C	T	rs149496837		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:164394337C>T	ENST00000280605.3	-	1	710	c.550G>A	c.(550-552)Gac>Aac	p.D184N		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	184						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CGGTTCACGTCGAAGACCGCC	0.522000													10	71					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16485145	16485145	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:16485145G>A	ENST00000354981.2	-	10	1205	c.1048C>T	c.(1048-1050)Cgc>Tgc	p.R350C	KIF16B_ENST00000408042.1_Missense_Mutation_p.R350C|KIF16B_ENST00000355755.3_Missense_Mutation_p.R350C|KIF16B_ENST00000378003.2_5'UTR	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	350	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TTTGCATAGCGAAGAGTACTT	0.398000													62	82					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124252580	124252580	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:124252580G>A	ENST00000375013.2	-	1	678	c.660C>T	c.(658-660)ttC>ttT	p.F220F		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TAGTGACAATGAAAACATAAG	0.413000													50	49					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22304895	22304895	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:22304895C>T	ENST00000337107.6	+	2	96	c.77C>T	c.(76-78)tCc>tTc	p.S26F		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	26					cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						TCTCGCCCTTCCAGCCGCGTT	0.627000													20	35					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201031193	201031193	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:201031193C>T	ENST00000362061.3	-	24	3158	c.2932G>A	c.(2932-2934)Ggg>Agg	p.G978R	CACNA1S_ENST00000367338.3_Missense_Mutation_p.G978R	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	978					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATGGGGTCCCCGTCCTTGTAC	0.617000													20	19					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70355166	70355166	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:70355166G>A	ENST00000305107.6	-	3	1039	c.993C>T	c.(991-993)atC>atT	p.I331I	UGT2B4_ENST00000512583.1_Silent_p.I331I|UGT2B4_ENST00000381096.3_Silent_p.I195I|UGT2B4_ENST00000506580.1_5'UTR	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	331					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						CCTTTTGTGGGATCTTGGCAA	0.398000													28	103					0	0	1	0	0
MAN2B2	23324	broad.mit.edu	37	4	6580149	6580149	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:6580149G>A	ENST00000285599.3	+	3	351	c.315G>A	c.(313-315)ctG>ctA	p.L105L	MAN2B2_ENST00000504248.1_Silent_p.L105L	NM_015274.1	NP_056089.1	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	105					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	30						AAGGACGCCTGGAATTTGTCA	0.592000													24	12					0	0	1	0	0
NDUFAF2	91942	broad.mit.edu	37	5	60241050	60241050	+	Translation_Start_Site	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:60241050G>A	ENST00000296597.5	+	0	95				NDUFAF2_ENST00000511107.1_De_novo_Start_OutOfFrame	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2							membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				TGCGGGTCCCGCTGCTGGCAG	0.632000													3	19					0	0	1	0	0
RBM24	221662	broad.mit.edu	37	6	17292009	17292009	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:17292009C>T	ENST00000379052.5	+	4	606	c.370C>T	c.(370-372)Ccg>Tcg	p.P124S	RBM24_ENST00000508508.1_3'UTR|RBM24_ENST00000318204.5_Missense_Mutation_p.P79S|RBM24_ENST00000425446.2_Missense_Mutation_p.P66S	NM_001143942.1	NP_001137414.1	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24	124					cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	13	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			CTATGTCTATCCGCAGGCTTT	0.502000													144	140					0	0	1	0	0
KIAA1024	23251	broad.mit.edu	37	15	79755472	79755472	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:79755472C>T	ENST00000305428.3	+	3	2437	c.2362C>T	c.(2362-2364)Ctg>Ttg	p.L788L		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	788						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						AGATGGCTTCCTGGTGGAGCA	0.607000													12	63					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66074565	66074565	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:66074565G>A	ENST00000349533.6	+	12	1918	c.1733G>A	c.(1732-1734)gGa>gAa	p.G578E	LEPR_ENST00000371060.3_Missense_Mutation_p.G578E|LEPR_ENST00000371058.1_Missense_Mutation_p.G578E|LEPR_ENST00000371059.3_Missense_Mutation_p.G578E|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000344610.8_Missense_Mutation_p.G578E	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	578	Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GGTTTAAGTGGAAAAGAAGTA	0.303000													14	50					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101295467	101295467	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:101295467C>T	ENST00000538618.1	+	4	402	c.402C>T	c.(400-402)atC>atT	p.I134I	ANO4_ENST00000392977.3_5'UTR|ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000299222.9_5'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GTTTGCAAATCCATCAACGGC	0.493000										HNSCC(74;0.22)			21	45					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6631189	6631189	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:6631189C>T	ENST00000333172.6	+	2	605	c.412C>T	c.(412-414)Cct>Tct	p.P138S	TAS1R1_ENST00000328191.4_Missense_Mutation_p.P138S|TAS1R1_ENST00000351136.3_Missense_Mutation_p.P138S	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	138					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CCACTATTCCCCTACGGTGCT	0.592000													56	92					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70201880	70201880	+	Silent	SNP	C	C	T	rs145603046	byFrequency	TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:70201880C>T	ENST00000253925.7	+	18	2666	c.2451C>T	c.(2449-2451)ggC>ggT	p.G817G	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Silent_p.G817G	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	817					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AAGAAAAGGGCCGACCTGGAC	0.547000													35	34					0	0	1	0	0
CXCL13	10563	broad.mit.edu	37	4	78532168	78532168	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:78532168C>T	ENST00000286758.4	+	5	383	c.305C>T	c.(304-306)cCa>cTa	p.P102L		NM_006419.2	NP_006410.1	O43927	CXL13_HUMAN	chemokine (C-X-C motif) ligand 13	102					activation of Rap GTPase activity|B cell chemotaxis|cell-cell signaling|chronic inflammatory response|defense response to bacterium|elevation of cytosolic calcium ion concentration|endothelial cell chemotaxis to fibroblast growth factor|germinal center formation|lymphocyte chemotaxis across high endothelial venule|negative regulation of apoptosis|positive regulation of cell-cell adhesion mediated by integrin|positive regulation of integrin activation|positive regulation of T cell chemotaxis|regulation of angiogenesis|regulation of humoral immune response	extracellular space|soluble fraction	CCR10 chemokine receptor binding|chemokine activity|CXCR3 chemokine receptor binding|CXCR5 chemokine receptor binding|fibroblast growth factor 2 binding|heparin binding|protein heterodimerization activity|receptor agonist activity			large_intestine(1)|ovary(1)|skin(1)|urinary_tract(1)	4						CTACCAGTTCCAGTGTTTAAG	0.378000													40	53					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3045437	3045437	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:3045437G>A	ENST00000520002.1	-	37	6132	c.5577C>T	c.(5575-5577)atC>atT	p.I1859I	CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000602723.1_Silent_p.I1859I|CSMD1_ENST00000400186.3_Silent_p.I1859I|CSMD1_ENST00000602557.1_Silent_p.I1859I|CSMD1_ENST00000542608.1_Silent_p.I1858I|CSMD1_ENST00000539096.1_Silent_p.I1858I|CSMD1_ENST00000537824.1_Silent_p.I1858I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1859	CUB 11.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACCATCGTGGATCTCAAGGG	0.448000													4	22					0	0	1	0	0
CEACAM16	388551	broad.mit.edu	37	19	45206729	45206729	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:45206729G>A	ENST00000587331.1	+	3	363	c.148G>A	c.(148-150)Gcc>Acc	p.A50T	CEACAM16_ENST00000405314.2_Missense_Mutation_p.A50T|CTB-171A8.1_ENST00000590796.1_RNA	NM_001039213.2	NP_001034302.2	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 16	50										endometrium(3)|large_intestine(2)|lung(3)|ovary(1)	9	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				GGAACTGCTCGCCTACAGCTG	0.647000													11	52					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349474	65349474	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:65349474G>C	ENST00000309295.4	+	9	1596	c.1331G>C	c.(1330-1332)gGg>gCg	p.G444A		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	444										central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						GAGGCGACAGGGGTGATGCCT	0.607000													26	22					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71318067	71318067	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:71318067G>A	ENST00000338099.5	-	3	2093	c.1757C>T	c.(1756-1758)tCg>tTg	p.S586L	FTSJD1_ENST00000434935.2_Missense_Mutation_p.S586L			Q8IYT2	FTSJ1_HUMAN		586						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ACGGAGAGTCGAAAAGCCCAC	0.433000													15	26					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124393214	124393214	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:124393214G>A	ENST00000360013.3	+	49	7073	c.6946G>A	c.(6946-6948)Gac>Aac	p.D2316N	KALRN_ENST00000291478.4_Missense_Mutation_p.D619N|KALRN_ENST00000459915.1_Missense_Mutation_p.D407N|KALRN_ENST00000428018.2_Missense_Mutation_p.D587N|KALRN_ENST00000393496.1_Missense_Mutation_p.D656N	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2315					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CCAGCAGAACGACCTGGGAGG	0.537000													58	60					0	0	1	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84517853	84517853	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:84517853G>A	ENST00000331369.5	+	0	47																											CCACGTGCAGGAAGCCGGGTG	0.672000													6	5					0	0	1	0	0
ZNF468	90333	broad.mit.edu	37	19	53344418	53344418	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:53344418G>A	ENST00000595646.1	-	4	1249	c.1129C>T	c.(1129-1131)Cat>Tat	p.H377Y	ZNF468_ENST00000396409.4_Missense_Mutation_p.H324Y|ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000390651.4_Missense_Mutation_p.H324Y|ZNF28_ENST00000594602.1_Intron			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		TCTCCAGTATGAAGTCTATGA	0.388000													47	77					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095234	69095234	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:69095234C>T	ENST00000332644.5	-	8	848	c.686_splice	c.e8-1	p.K229_splice		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	229	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						AATTATTTTTCCTAGAGGACA	0.323000													5	37					0	0	1	0	0
ORC1	4998	broad.mit.edu	37	1	52850901	52850901	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:52850901G>A	ENST00000371568.3	-	10	1733	c.1515C>T	c.(1513-1515)ccC>ccT	p.P505P	ORC1_ENST00000371566.1_Silent_p.P505P	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	505	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GTTCCCGACAGGGAAGAGACT	0.473000													18	95					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23713508	23713508	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:23713508G>A	ENST00000256797.4	-	11	1480	c.1312C>T	c.(1312-1314)Cca>Tca	p.P438S	ERN2_ENST00000457008.2_Missense_Mutation_p.P390S	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	390					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GTATTCTCTGGAGGTCTTGTC	0.632000													49	77					0	0	1	0	0
C17orf103	256302	broad.mit.edu	37	17	21147471	21147471	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:21147471G>A	ENST00000468196.1	-	2	317	c.172C>T	c.(172-174)Ccg>Tcg	p.P58S	C17orf103_ENST00000399011.2_Missense_Mutation_p.T57I			Q8N6N6	GTL3B_HUMAN	chromosome 17 open reading frame 103	0										endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6						TGGGACCTCGGTGTGCTGCAG	0.647000													20	28					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166145	140166145	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140166145C>T	ENST00000504120.2	+	1	270	c.270C>T	c.(268-270)atC>atT	p.I90I	PCDHA1_ENST00000394633.3_Silent_p.I90I|PCDHA1_ENST00000378133.3_Silent_p.I90I	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGATCGCGAGG	0.577000													33	116					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247751946	247751946	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:247751946C>T	ENST00000320065.1	+	1	285	c.285C>T	c.(283-285)atC>atT	p.I95I	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGAAAACTATCGCCTATGGTG	0.527000													23	156					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86392944	86392944	+	Missense_Mutation	SNP	G	G	A	rs143666045		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:86392944G>A	ENST00000285379.5	+	7	939	c.709G>A	c.(709-711)Gaa>Aaa	p.E237K		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	237					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	GGGTGAACCCGAAGAACTGAT	0.398000													17	105					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23862683	23862683	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:23862683G>A	ENST00000405093.3	-	23	3043	c.2973C>T	c.(2971-2973)atC>atT	p.I991I	MYH6_ENST00000356287.3_Silent_p.I991I	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	991					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TCAGCTTAGCGATGATTTCAT	0.522000													83	90					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41137656	41137656	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr21:41137656G>A	ENST00000380588.4	+	3	398	c.295G>A	c.(295-297)Gac>Aac	p.D99N	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	99	Ig-like V-type 1.					integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				TCAGAGGTACGACCAGGGCGG	0.567000													14	37					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769860	50769860	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:50769860A>G	ENST00000216923.4	-	6	1220	c.871T>C	c.(871-873)Ttc>Ctc	p.F291L	ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000346617.4_Missense_Mutation_p.F237L|ZFP64_ENST00000371515.4_Missense_Mutation_p.F289L	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						ACATTGCAGAACTCGCACTTG	0.547000													64	48					0	0	1	0	0
MTMR1	8776	broad.mit.edu	37	X	149924335	149924335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:149924335C>T	ENST00000445323.2	+	15	1976	c.1855C>T	c.(1855-1857)Cag>Tag	p.Q619*	MTMR1_ENST00000370390.3_Nonsense_Mutation_p.Q611*|MTMR1_ENST00000544228.1_Nonsense_Mutation_p.Q611*|MTMR1_ENST00000541925.1_Nonsense_Mutation_p.Q517*|MTMR1_ENST00000538506.1_3'UTR			Q13613	MTMR1_HUMAN	myotubularin related protein 1	611						plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GATGAGACCTCAGGTATCTTT	0.338000													23	16					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38039157	38039157	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:38039157C>T	ENST00000599616.1	+	4	257	c.257C>T	c.(256-258)tCc>tTc	p.S86F	Z83844.1_ENST00000456099.1_RNA|SH3BP1_ENST00000442465.2_Missense_Mutation_p.S150F|SH3BP1_ENST00000357436.4_Missense_Mutation_p.S150F|SH3BP1_ENST00000336738.5_Missense_Mutation_p.S150F|SH3BP1_ENST00000495174.1_3'UTR			Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	150	BAR.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					AAGCTCGTGTCCGACTGGAAC	0.617000											OREG0026546	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	39					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784955	9784955	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:9784955C>T	ENST00000304374.2	+	1	1698	c.1302C>T	c.(1300-1302)ttC>ttT	p.F434F		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	434					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	AGGGTCCTTTCGATCGCATGT	0.557000													7	73					0	0	1	0	0
SLC17A2	10246	broad.mit.edu	37	6	25923937	25923937	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:25923937C>T	ENST00000377850.3	-	3	750	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	SLC17A2_ENST00000265425.3_Missense_Mutation_p.E76K|SLC17A2_ENST00000360488.3_Missense_Mutation_p.E76K			O00624	NPT3_HUMAN	solute carrier family 17, member 2	76					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						GTATCAAATTCCTTGATGGAT	0.433000													82	80					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204844	9204844	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9204844G>A	ENST00000429566.3	+	1	990	c.924G>A	c.(922-924)aaG>aaA	p.K308K		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.K308N(1)		breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TCAACAGAAAGATCACCTCAT	0.498000													10	39					0	0	1	0	0
STK38	11329	broad.mit.edu	37	6	36492192	36492192	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:36492192G>A	ENST00000229812.7	-	4	517	c.232C>T	c.(232-234)Cgt>Tgt	p.R78C		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	78	Interaction with S100B.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTCTTCAAACGAAGAAACTCT	0.393000													36	64					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16024698	16024698	+	Missense_Mutation	SNP	G	G	A	rs149231661		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:16024698G>A	ENST00000326742.7	-	11	1355	c.1354C>T	c.(1354-1356)Cgc>Tgc	p.R452C	CYP4F11_ENST00000248041.7_Silent_p.F473F|CYP4F11_ENST00000402119.3_Silent_p.F473F			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	0					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						CAGCCATGGCGAACGCCTGCC	0.612000													21	31					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307693	140307693	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140307693G>A	ENST00000253807.2	+	1	1216	c.1216G>A	c.(1216-1218)Gag>Aag	p.E406K	PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.E406K|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGACCGGGAGCAGATCAG	0.532000													9	44					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109201509	109201509	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:109201509C>T	ENST00000326495.5	-	8	724	c.631G>A	c.(631-633)Gag>Aag	p.E211K	SSH1_ENST00000360239.3_5'UTR|SSH1_ENST00000551165.1_Missense_Mutation_p.E211K|SSH1_ENST00000326470.5_Missense_Mutation_p.E222K	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	211					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						ATGCAGCTCTCATAGTAGGTA	0.617000													8	112					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105139465	105139465	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:105139465G>A	ENST00000428173.2	+	7	832	c.529G>A	c.(529-531)Gac>Aac	p.D177N	NRK_ENST00000243300.9_Missense_Mutation_p.D177N			Q7Z2Y5	NRK_HUMAN	Nik related kinase	177	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						AATTCACCGGGACATCAAAGG	0.348000										HNSCC(51;0.14)			33	34					0	0	1	0	0
IFNA5	3442	broad.mit.edu	37	9	21305245	21305245	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:21305245G>A	ENST00000259555.4	-	1	67	c.11C>T	c.(10-12)cCc>cTc	p.P4L		NM_002169.2	NP_002160.1	P01569	IFNA5_HUMAN	interferon, alpha 5	4					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	7				Lung(24;2.34e-24)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TAAAACAAAGGGCAAGGCCAT	0.522000													62	20					0	0	1	0	0
MSLN	10232	broad.mit.edu	37	16	815580	815580	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:815580C>T	ENST00000566549.1	+	9	1175	c.758C>T	c.(757-759)cCc>cTc	p.P253L	MSLN_ENST00000563941.1_Missense_Mutation_p.P253L|MSLN_ENST00000545450.2_Missense_Mutation_p.P253L|MSLN_ENST00000382862.3_Missense_Mutation_p.P253L			Q13421	MSLN_HUMAN	mesothelin	253					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				GGCCTGCTGCCCGTGCTGGGC	0.711000													9	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090186	9090186	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9090186C>T	ENST00000397910.4	-	1	1832	c.1629G>A	c.(1627-1629)atG>atA	p.M543I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	543	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTCTGTTTTCATGCTAGGAC	0.532000													20	51					0	0	1	0	0
KIAA2013	90231	broad.mit.edu	37	1	11985529	11985529	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:11985529T>A	ENST00000376572.3	-	1	951	c.766A>T	c.(766-768)Act>Tct	p.T256S	KIAA2013_ENST00000376576.3_Missense_Mutation_p.T256S	NM_138346.2	NP_612355.1	Q8IYS2	K2013_HUMAN	KIAA2013	256						integral to membrane				endometrium(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	7	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCAACCCAGTGGGCGTAGGC	0.657000													14	11					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072151	17072151	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:17072151C>A	ENST00000359963.3	-	1	1549	c.1290G>T	c.(1288-1290)ttG>ttT	p.L430F		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	430					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGGGCCCTTCCAATCTGCTTC	0.493000													23	104					2.89027e-11	2.95937e-11	1	1	0
KLHL24	54800	broad.mit.edu	37	3	183397024	183397024	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:183397024C>T	ENST00000454652.1	+	9	2139	c.1753C>T	c.(1753-1755)Cat>Tat	p.H585Y	KLHL24_ENST00000242810.6_Missense_Mutation_p.H585Y			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	585						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			AGTGTCCTATCATGGCTGTGT	0.453000													38	33					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43411146	43411146	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:43411146G>A	ENST00000187910.2	-	5	1233	c.1168C>T	c.(1168-1170)Ctc>Ttc	p.L390F	PSG6_ENST00000402603.4_Missense_Mutation_p.L297F|PSG6_ENST00000292125.2_Missense_Mutation_p.L390F	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				CAAGCATAGAGCCCGCTATGA	0.448000													124	165					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54306810	54306810	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:54306810C>T	ENST00000545554.1	+	1	1710	c.1710C>T	c.(1708-1710)ttC>ttT	p.F570F	UNC13C_ENST00000260323.11_Silent_p.F570F|UNC13C_ENST00000537900.1_Silent_p.F570F			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	570					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATCAGTTTTTCACTAGAACTA	0.428000													15	22					0	0	1	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157685	26157685	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:26157685C>T	ENST00000325250.1	+	2	770	c.583C>T	c.(583-585)Ccc>Tcc	p.P195S		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	195	MAGE.						protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						AGAAAAAATTCCCAAGACTGG	0.443000													8	7					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45739290	45739290	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr21:45739290C>T	ENST00000403390.1	+	12	1260	c.1260C>T	c.(1258-1260)ctC>ctT	p.L420L	PFKL_ENST00000349048.4_Silent_p.L373L			P17858	K6PL_HUMAN	phosphofructokinase, liver	373					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		CCACCCAGCTCCGTGGTGGGT	0.592000													8	95					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16266988	16266988	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:16266988C>T	ENST00000343518.6	-	9	1512	c.1461G>A	c.(1459-1461)agG>agA	p.R487R		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	487										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TTCTGCTTTTCCTTGGTGGAA	0.433000													59	217					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191941042	191941042	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:191941042G>A	ENST00000392320.2	-	4	597	c.283C>T	c.(283-285)Cat>Tat	p.H95Y	STAT4_ENST00000358470.4_Missense_Mutation_p.H95Y	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	95					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GGATTTCCATGAAATTTTCCC	0.328000													29	31					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152327955	152327955	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:152327955G>A	ENST00000388718.5	-	3	2379	c.2307C>T	c.(2305-2307)agC>agT	p.S769S	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	769	Ser-rich.						calcium ion binding|structural molecule activity	p.S769S(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGGCCATAGCTAGACTGAC	0.517000													9	668					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578400	7578400	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:7578400G>A	ENST00000420246.2	-	5	662	c.530C>T	c.(529-531)cCc>cTc	p.P177L	TP53_ENST00000269305.4_Missense_Mutation_p.P177L|TP53_ENST00000455263.2_Missense_Mutation_p.P177L|TP53_ENST00000445888.2_Missense_Mutation_p.P177L|TP53_ENST00000413465.2_Missense_Mutation_p.P177L|TP53_ENST00000359597.4_Missense_Mutation_p.P177L|TP53_ENST00000574684.1_5'UTR	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	177	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		CP -> FS (in a sporadic cancer; somatic mutation).|P -> A (in a sporadic cancer; somatic mutation).|P -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|P -> H (in sporadic cancers; somatic mutation).|P -> I (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|P -> L (in sporadic cancers; somatic mutation).|P -> R (in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).|P -> T (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.P177R(18)|p.P177L(17)|p.P177_C182delPHHERC(8)|p.0?(8)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.P177H(3)|p.R175_E180delRCPHHE(3)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.C176fs*65(1)|p.C176_P177delCP(1)|p.V173fs*69(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.P177fs*69(1)|p.R175_H178>X(1)|p.H168fs*69(1)|p.E171_H179delEVVRRCPHH(1)|p.P45R(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.P177I(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.P84R(1)|p.R174fs*3(1)|p.E171fs*61(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCATGGTGGGGGCAGCGCCT	0.647000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	60					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81589138	81589138	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:81589138G>A	ENST00000356860.3	-	37	3312	c.2974C>T	c.(2974-2976)Cat>Tat	p.H992Y	CACNA2D1_ENST00000535308.1_Missense_Mutation_p.H204Y|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.H1004Y	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	1004						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTTTCTCCATGAAAGATTCTG	0.333000													5	20					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53392612	53392612	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:53392612A>T	ENST00000226067.5	+	3	949	c.476A>T	c.(475-477)aAt>aTt	p.N159I	HLF_ENST00000430986.2_Missense_Mutation_p.N74I|HLF_ENST00000575345.1_Missense_Mutation_p.N74I|HLF_ENST00000573945.1_Missense_Mutation_p.N74I	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	159	Pro-rich (proline/acidic region (PAR)).				multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						GCAAACCGCAATACACCAAGT	0.517000			T	TCF3	ALL								35	37					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179427525	179427525	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:179427525C>T	ENST00000589042.1	-	326	83558	c.83334G>A	c.(83332-83334)gtG>gtA	p.V27778V	TTN_ENST00000591111.1_Silent_p.V26137V|TTN_ENST00000342175.6_Silent_p.V18905V|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.V18838V|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000460472.2_Silent_p.V18713V|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000342992.6_Silent_p.V25210V|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	26137	Fibronectin type-III 102.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCTTTCTTCACTTCTCTTA	0.398000													15	16					0	0	1	0	0
MIR527	574497	broad.mit.edu	37	19	54257292	54257292	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:54257292G>A	ENST00000385244.1	+	0	21					NR_030219.1																						TGACTGCAAAGGGAAGCCCTT	0.413000													9	207					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179604237	179604237	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:179604237C>T	ENST00000589042.1	-	48	13947	c.13723G>A	c.(13723-13725)Gaa>Aaa	p.E4575K	TTN_ENST00000591111.1_Missense_Mutation_p.E4258K|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E4404K|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E4337K|TTN_ENST00000460472.2_Missense_Mutation_p.E4212K|TTN_ENST00000342992.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4258	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTCTTTTTCCTCTGATGGT	0.448000													17	58					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117727192	117727192	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:117727192C>T	ENST00000276204.6	+	20	2229	c.2155C>T	c.(2155-2157)Ccc>Tcc	p.P719S	DOCK11_ENST00000276202.7_Missense_Mutation_p.P719S			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	719	DHR-1.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						AATTGAGCTTCCCATTCACCT	0.338000													30	31					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62235071	62235071	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:62235071C>T	ENST00000371158.2	+	5	615	c.501C>T	c.(499-501)gtC>gtT	p.V167V	INADL_ENST00000316485.6_Silent_p.V167V	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	167	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TGAAGGATGTCCAGCCAGGGA	0.403000													48	79					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141122267	141122267	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:141122267G>C	ENST00000389484.3	-	72	12065	c.11094C>G	c.(11092-11094)gaC>gaG	p.D3698E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3698	LDL-receptor class A 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTCTCCACAGTCGTCCTCTC	0.408000										TSP Lung(27;0.18)			5	101					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95081172	95081172	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:95081172G>A	ENST00000553947.1	+	5	1357	c.469G>A	c.(469-471)Gag>Aag	p.E157K	SERPINA3_ENST00000467132.1_Missense_Mutation_p.E132K|SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000393080.4_Missense_Mutation_p.E132K|SERPINA3_ENST00000393078.3_Missense_Mutation_p.E132K			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	132					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GTCCAGCGATGAGCTGCAGCT	0.537000													16	30					0	0	1	0	0
ABTB2	25841	broad.mit.edu	37	11	34226192	34226192	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:34226192G>A	ENST00000435224.2	-	2	1353	c.929C>T	c.(928-930)tCc>tTc	p.S310F	ABTB2_ENST00000298992.2_Missense_Mutation_p.S124F|ABTB2_ENST00000530814.1_5'UTR	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	124							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				ATGGCCCAGGGACCCGCCGTT	0.627000													22	13					0	0	1	0	0
D2HGDH	728294	broad.mit.edu	37	2	242690671	242690671	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:242690671T>A	ENST00000321264.4	+	8	1217	c.1008T>A	c.(1006-1008)ttT>ttA	p.F336L	D2HGDH_ENST00000403782.1_Missense_Mutation_p.F202L|D2HGDH_ENST00000486953.1_Intron	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	336					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		AGAGTCCGTTTTACGTCCTCA	0.602000													20	86					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117683900	117683900	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:117683900C>T	ENST00000368508.3	-	21	3445	c.3247G>A	c.(3247-3249)Gaa>Aaa	p.E1083K	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.E1078K	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1083	Fibronectin type-III 5.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TAGAAAATTTCAAATTTTGTT	0.338000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								15	45					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	373472	373472	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:373472G>A	ENST00000342640.4	-	4	605	c.563C>T	c.(562-564)cCc>cTc	p.P188L	THEG_ENST00000346878.2_Missense_Mutation_p.P164L	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	188					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCTACCGGGCACTGTGAT	0.667000													16	31					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20793104	20793104	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:20793104C>T	ENST00000404938.2	+	27	4203	c.3551C>T	c.(3550-3552)tCa>tTa	p.S1184L	ABCB5_ENST00000258738.6_Missense_Mutation_p.S739L	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	739					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GAGGCCACTTCAGCCCTCGAT	0.398000													31	39					0	0	1	0	0
GOLGA5	9950	broad.mit.edu	37	14	93264102	93264102	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:93264102C>A	ENST00000163416.2	+	2	576	c.320C>A	c.(319-321)tCa>tAa	p.S107*	GOLGA5_ENST00000355976.2_Nonsense_Mutation_p.S107*	NM_005113.2	NP_005104.2	Q8TBA6	GOGA5_HUMAN	golgin A5	107					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		CCTAGGCCTTCATCCCATTTT	0.458000			T	RET	papillary thyroid								28	34					1.16021e-09	1.17637e-09	1	1	0
FBN2	2201	broad.mit.edu	37	5	127730894	127730894	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:127730894C>T	ENST00000508053.1	-	15	2126	c.1152G>A	c.(1150-1152)acG>acA	p.T384T	FBN2_ENST00000262464.4_Silent_p.T384T|FBN2_ENST00000508989.1_Silent_p.T351T			P35556	FBN2_HUMAN	fibrillin 2	384	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACTGCATTTTCGTCATTCTCC	0.547000													21	24					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131353841	131353841	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:131353841C>T	ENST00000372739.3	+	22	3202	c.3092C>T	c.(3091-3093)tCc>tTc	p.S1031F	SPTAN1_ENST00000358161.5_Missense_Mutation_p.S1031F|SPTAN1_ENST00000372731.4_Missense_Mutation_p.S1031F	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1031					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						CAGTCAGCCTCCCGGGAGAAT	0.562000													25	125					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196682902	196682902	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:196682902G>A	ENST00000367429.4	+	10	1614	c.1374G>A	c.(1372-1374)ggG>ggA	p.G458G		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	458	Sushi 8.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						TTGAGAATGGGTTTATTTCTG	0.294000													4	35					0	0	1	0	0
TOM1	10043	broad.mit.edu	37	22	35719109	35719109	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:35719109C>T	ENST00000382034.5	+	5	446	c.104C>T	c.(103-105)aCc>aTc	p.T35I	TOM1_ENST00000411850.1_Missense_Mutation_p.T102I|TOM1_ENST00000447733.1_Missense_Mutation_p.T69I|TOM1_ENST00000436462.2_Missense_Mutation_p.T64I|TOM1_ENST00000425375.1_Missense_Mutation_p.T102I|TOM1_ENST00000449058.2_Missense_Mutation_p.T102I			O60784	TOM1_HUMAN	target of myb1 (chicken)	102	VHS.				endocytosis|endosome transport|intracellular protein transport	cytosol|early endosome|membrane	protein binding			NS(1)|breast(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(2)	19						CTGGTGAGGACCATCCTGCCC	0.607000													49	30					0	0	1	0	0
TSNAXIP1	55815	broad.mit.edu	37	16	67860896	67860896	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:67860896G>A	ENST00000388833.3	+	13	1800	c.1423G>A	c.(1423-1425)Gag>Aag	p.E475K	TSNAXIP1_ENST00000561639.1_Missense_Mutation_p.E529K|TSNAXIP1_ENST00000415766.3_Missense_Mutation_p.E460K	NM_018430.2	NP_060900.2	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein 1	475					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|soft_tissue(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		CACCCAGAAGGAGACAGTAGC	0.522000													38	80					0	0	1	0	0
BAAT	570	broad.mit.edu	37	9	104133441	104133441	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:104133441C>T	ENST00000259407.2	-	2	354	c.246G>A	c.(244-246)ctG>ctA	p.L82L	BAAT_ENST00000395051.3_Silent_p.L82L	NM_001127610.1|NM_001701.3	NP_001121082.1|NP_001692.1	Q14032	BAAT_HUMAN	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	82					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	TTTCAGGTTTCAGAGACCAGA	0.423000													90	31					0	0	1	0	0
METTL7B	196410	broad.mit.edu	37	12	56075839	56075839	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:56075839C>T	ENST00000394252.3	+	1	510	c.301C>T	c.(301-303)Ccc>Tcc	p.P101S		NM_152637.2	NP_689850.2	Q6UX53	MET7B_HUMAN	methyltransferase like 7B	101							methyltransferase activity			kidney(1)|large_intestine(1)|lung(4)	6						AGACCCAAATCCCCACTTTGA	0.582000													13	50					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113238119	113238119	+	Missense_Mutation	SNP	C	C	T	rs140221891		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:113238119C>T	ENST00000369644.1	+	12	2563	c.1534C>T	c.(1534-1536)Cgg>Tgg	p.R512W	MOV10_ENST00000413052.2_Missense_Mutation_p.R568W|MOV10_ENST00000357443.2_Missense_Mutation_p.R568W|MOV10_ENST00000369645.1_Missense_Mutation_p.R568W|RP11-426L16.3_ENST00000421943.1_RNA|MOV10_ENST00000468624.1_3'UTR			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	568					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TCAAAGGCTCCGGGTCCACCT	0.597000													12	46					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3678689	3678689	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:3678689C>T	ENST00000344754.4	-	8	1877	c.1878G>A	c.(1876-1878)gtG>gtA	p.V626V	SIGLEC1_ENST00000202578.4_Silent_p.V626V	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	626	Ig-like C2-type 6.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGTCGCTGTCCACACGGCACA	0.672000													10	36					0	0	1	0	0
MFSD11	79157	broad.mit.edu	37	17	74771214	74771214	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:74771214C>T	ENST00000588460.1	+	11	3052	c.1010C>T	c.(1009-1011)cCt>cTt	p.P337L	MFSD11_ENST00000355954.3_Missense_Mutation_p.P285L|MFSD11_ENST00000593181.1_Missense_Mutation_p.P285L|MFSD11_ENST00000590514.1_Missense_Mutation_p.P337L|MFSD11_ENST00000590070.1_3'UTR|MFSD11_ENST00000336509.4_Missense_Mutation_p.P337L|MFSD11_ENST00000586622.1_Missense_Mutation_p.P337L	NM_001242534.1	NP_001229463.1	O43934	MFS11_HUMAN	major facilitator superfamily domain containing 11	337						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)	17						CCGATTGCTCCTGTTAAAGGA	0.463000													35	57					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38743382	38743382	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:38743382G>A	ENST00000449082.2	-	26	4604	c.4605C>T	c.(4603-4605)ttC>ttT	p.F1535F		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1535					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AGCCATTTGTGAAGTAGTACT	0.488000													31	30					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16328252	16328252	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:16328252G>A	ENST00000244769.4	-	8	1226	c.290C>T	c.(289-291)cCc>cTc	p.P97L	ATXN1_ENST00000436367.1_Missense_Mutation_p.P97L	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	97					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGTGGCCACGGGGACAGACCT	0.642000													74	122					0	0	1	0	0
BPIFA3	128861	broad.mit.edu	37	20	31805443	31805443	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:31805443G>A	ENST00000375454.3	+	1	311	c.101G>A	c.(100-102)aGa>aAa	p.R34K	BPIFA3_ENST00000490499.1_3'UTR|BPIFA3_ENST00000375452.3_Missense_Mutation_p.R34K	NM_178466.3	NP_848561.2	Q9BQP9	SPLC3_HUMAN	BPI fold containing family A, member 3	34						extracellular region	lipid binding										CAAGCCCACAGAGACAACAAA	0.622000													25	77					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29598891	29598891	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr13:29598891G>A	ENST00000431530.3	+	1	144	c.86G>A	c.(85-87)aGa>aAa	p.R29K		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	19						cytoplasm|microtubule	microtubule binding|protein homodimerization activity	p.R29I(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CGGGACAACAGAAATGCAGCA	0.458000													38	22					0	0	1	0	0
FERMT1	55612	broad.mit.edu	37	20	6065781	6065781	+	Missense_Mutation	SNP	C	C	T	rs151300234		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:6065781C>T	ENST00000217289.4	-	12	2313	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	FERMT1_ENST00000536936.1_Missense_Mutation_p.E252K|FERMT1_ENST00000478194.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	509	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						TCCATGTTTTCGAGACTGGAA	0.448000													44	68					0	0	1	0	0
CES4A	283848	broad.mit.edu	37	16	67039259	67039259	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:67039259C>T	ENST00000540947.2	+	11	1462	c.1278C>T	c.(1276-1278)ttC>ttT	p.F426F	CES4A_ENST00000398354.1_Silent_p.F399F|CES4A_ENST00000540579.1_Silent_p.F328F|CES4A_ENST00000535696.1_Silent_p.F332F|CES4A_ENST00000326686.5_Silent_p.F426F|CES4A_ENST00000541479.1_Silent_p.F422F|CES4A_ENST00000338718.4_Silent_p.F449F	NM_173815.6	NP_776176.5	Q5XG92	EST4A_HUMAN	carboxylesterase 4A	426						extracellular region	carboxylesterase activity	p.F399L(1)		large_intestine(2)|liver(2)|lung(4)|ovary(1)	9						ATGCCACTTTCGTGTATGCCA	0.532000													24	61					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115828696	115828696	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:115828696C>T	ENST00000369512.2	-	3	889	c.721G>A	c.(721-723)Gcc>Acc	p.A241T	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	241					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	GCAGGTCAGGCTCTTCTCACA	0.552000													36	38					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442627	138442627	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:138442627C>T	ENST00000344876.4	-	4	3350	c.2964G>A	c.(2962-2964)aaG>aaA	p.K988K	PCDH18_ENST00000412923.2_Silent_p.K987K|PCDH18_ENST00000510305.1_Silent_p.K199K|PCDH18_ENST00000511115.1_Silent_p.K168K|PCDH18_ENST00000507846.1_Silent_p.K767K	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	988	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TTGGGGAGTCCTTTCCAAAGG	0.527000													7	69					0	0	1	0	0
KAAG1	353219	broad.mit.edu	37	6	24358078	24358078	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:24358078G>A	ENST00000274766.1	+	1	948	c.211G>A	c.(211-213)Gaa>Aaa	p.E71K	DCDC2_ENST00000378454.3_5'UTR	NM_181337.3	NP_851854.1	Q9UBP8	KAAG1_HUMAN	kidney associated antigen 1	71					immune response					central_nervous_system(1)|lung(1)|prostate(1)	3						ATCGCCTCCTGAAACGAACGA	0.657000													25	66					0	0	1	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54903752	54903752	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:54903752C>T	ENST00000293373.6	+	7	797	c.718C>T	c.(718-720)Cct>Tct	p.P240S	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.P190S|NCKAP1L_ENST00000552211.1_3'UTR	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	240					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CATGATTAACCCTGCTAATTC	0.493000													49	77					0	0	1	0	0
PAN3	255967	broad.mit.edu	37	13	28750652	28750652	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr13:28750652C>T	ENST00000399613.1	+	3	200	c.137C>T	c.(136-138)tCc>tTc	p.S46F	PAN3_ENST00000380958.3_Missense_Mutation_p.S192F			Q58A45	PAN3_HUMAN	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	192	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		AGTAGCAGCTCCCCAAGCCTT	0.358000													50	29					0	0	1	0	0
CLDN3	1365	broad.mit.edu	37	7	73184018	73184018	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:73184018C>G	ENST00000395145.2	-	1	582	c.362G>C	c.(361-363)gGc>gCc	p.G121A		NM_001306.3	NP_001297.1	O15551	CLD3_HUMAN	claudin 3	121					response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity			kidney(1)|lung(1)	2		Lung NSC(55;0.159)				GAACAGCACGCCTGCCACGAT	0.672000													24	25					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123109300	123109300	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:123109300C>T	ENST00000466202.1	-	9	2125	c.1549G>A	c.(1549-1551)Gat>Aat	p.D517N	IQUB_ENST00000434450.1_Missense_Mutation_p.D517N|IQUB_ENST00000324698.6_Missense_Mutation_p.D517N			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	517										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						AACAGCACATCCAGCCTCTCA	0.358000													34	51					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86089626	86089626	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:86089626G>A	ENST00000330753.4	+	2	2535	c.1768G>A	c.(1768-1770)Gag>Aag	p.E590K	FLRT2_ENST00000554746.1_Missense_Mutation_p.E590K	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	590					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGATTATTGCGAGGCAGGCAC	0.488000													32	164					0	0	1	0	0
ENTPD3	956	broad.mit.edu	37	3	40464578	40464578	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:40464578G>A	ENST00000301825.3	+	8	1187	c.1069G>A	c.(1069-1071)Ggg>Agg	p.G357R	ENTPD3-AS1_ENST00000425156.1_RNA|ENTPD3-AS1_ENST00000439293.1_RNA|ENTPD3_ENST00000445129.1_Missense_Mutation_p.G357R|ENTPD3_ENST00000456402.1_Missense_Mutation_p.G357R|ENTPD3-AS1_ENST00000452768.1_RNA	NM_001248.2	NP_001239.2	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase 3	357						integral to membrane	ATP binding|hydrolase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		TTCTTTTGATGGGGTTTATCA	0.403000													53	42					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5904058	5904058	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:5904058G>A	ENST00000378961.4	+	4	1472	c.1268G>A	c.(1267-1269)gGa>gAa	p.G423E		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	423						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						AGAGGCAGGGGAGGGGAGCCA	0.532000													52	127					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343937	248343937	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:248343937C>T	ENST00000359682.2	+	1	650	c.650C>T	c.(649-651)tCc>tTc	p.S217F		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATCATTGCTTCCTATGCTCGA	0.433000													31	214					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99515323	99515323	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr13:99515323G>A	ENST00000376460.1	-	32	3609	c.3529C>T	c.(3529-3531)Cag>Tag	p.Q1177*	DOCK9_ENST00000339416.2_Nonsense_Mutation_p.Q1178*|DOCK9_ENST00000448493.2_Nonsense_Mutation_p.Q1189*|DOCK9_ENST00000442173.1_Nonsense_Mutation_p.Q1177*|DOCK9_ENST00000461998.1_5'UTR	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1178					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTGATCCGCTGGACGTTTTCA	0.517000													9	5					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137206693	137206693	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:137206693G>A	ENST00000453654.1	-	21	1806	c.1267C>T	c.(1267-1269)Cgt>Tgt	p.R423C	DGKI_ENST00000424189.2_Missense_Mutation_p.R744C|DGKI_ENST00000288490.5_Missense_Mutation_p.R723C|DGKI_ENST00000446122.1_Missense_Mutation_p.R723C			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	723	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						ATCCTCAGACGATCTGGGACA	0.463000													16	14					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96134470	96134470	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:96134470G>A	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		CAGATCACGGGAATTACAAGT	0.418000			T	TRA@	T-ALL								28	36					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40055069	40055069	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:40055069G>A	ENST00000336649.4	+	15	2296	c.2296G>A	c.(2296-2298)Gac>Aac	p.D766N	CACNA1I_ENST00000407673.1_Missense_Mutation_p.D725N|CACNA1I_ENST00000404898.1_Missense_Mutation_p.D725N|CACNA1I_ENST00000402142.3_Missense_Mutation_p.D760N|CACNA1I_ENST00000401624.1_Missense_Mutation_p.D760N|CACNA1I_ENST00000400164.3_Missense_Mutation_p.D725N			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	760					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GAAGACCATGGACAACGTGGC	0.627000													6	80					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70201881	70201881	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:70201881C>T	ENST00000253925.7	+	18	2667	c.2452C>T	c.(2452-2454)Cga>Tga	p.R818*	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Nonsense_Mutation_p.R818*	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	818					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AGAAAAGGGCCGACCTGGACA	0.542000													36	34					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121348916	121348916	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:121348916C>T	ENST00000260197.7	+	3	621	c.492C>T	c.(490-492)atC>atT	p.I164I	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	164					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AAGCTGTTATCGCCCAGTTCT	0.478000													4	20					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20648307	20648307	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:20648307C>T	ENST00000525748.1	+	8	1587	c.1314C>T	c.(1312-1314)atC>atT	p.I438I		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	438					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	TCCTCCTCATCCGAGGAGTCA	0.562000													56	33					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38119752	38119752	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:38119752C>T	ENST00000261439.4	+	17	3256	c.2901C>T	c.(2899-2901)gcC>gcT	p.A967A	TBC1D1_ENST00000508802.1_Intron|TBC1D1_ENST00000407365.1_3'UTR	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	967	Rab-GAP TBC.					nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						TCTACGCTGCCCCCTGGTTCC	0.532000													56	187					0	0	1	0	0
SSFA2	6744	broad.mit.edu	37	2	182766492	182766492	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:182766492G>A	ENST00000431877.2	+	8	891		c.e8-1		SSFA2_ENST00000428267.2_Splice_Site|SSFA2_ENST00000409001.1_Splice_Site|SSFA2_ENST00000320370.7_Splice_Site	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2							cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TCTTTTGGTAGGCCGTTTTCG	0.318000													5	52					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17597610	17597610	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:17597610G>A	ENST00000375460.3	+	9	1024	c.984G>A	c.(982-984)agG>agA	p.R328R		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	328					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AGCTGGCCAGGAAGGCCGGCT	0.652000													19	24					0	0	1	0	0
PTRHD1	391356	broad.mit.edu	37	2	25016004	25016004	+	Silent	SNP	C	C	T	rs147683338		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:25016004C>T	ENST00000328379.4	-	1	247	c.243G>A	c.(241-243)gtG>gtA	p.V81V		NM_001013663.1	NP_001013685.1	Q6GMV3	PTRD1_HUMAN	peptidyl-tRNA hydrolase domain containing 1	81					translation		aminoacyl-tRNA hydrolase activity|protein tyrosine phosphatase activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(2)|lung(1)|skin(1)	6						CCTCGAGGACCACTTTGCGCA	0.682000													17	31					0	0	1	0	0
LCE3E	353145	broad.mit.edu	37	1	152538467	152538467	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:152538467C>T	ENST00000368789.1	-	2	273	c.218G>A	c.(217-219)aGg>aAg	p.R73K		NM_178435.2	NP_848522.1	Q5T5B0	LCE3E_HUMAN	late cornified envelope 3E	73					keratinization					lung(6)|ovary(1)	7	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		Lung(1;0.000294)|LUAD - Lung adenocarcinoma(1;0.00527)|LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)		ACCACTGCCCCTGTCACAGGA	0.652000													32	225					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128294260	128294260	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:128294260G>A	ENST00000368227.3	-	30	4593	c.4227C>T	c.(4225-4227)atC>atT	p.I1409I	PTPRK_ENST00000532331.1_Silent_p.I1414I|PTPRK_ENST00000368215.3_Silent_p.I1391I|PTPRK_ENST00000368207.3_Silent_p.I1424I|PTPRK_ENST00000368210.3_Silent_p.I1410I|PTPRK_ENST00000368213.5_Silent_p.I1398I|PTPRK_ENST00000368226.4_Silent_p.I1392I			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1391	Tyrosine-protein phosphatase 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TTTCAACAACGATGCCTATAG	0.478000													40	74					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511156	61511156	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:61511156G>A	ENST00000266070.4	-	16	6477	c.6152C>T	c.(6151-6153)tCc>tTc	p.S2051F	DIDO1_ENST00000395343.1_Missense_Mutation_p.S2051F	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	2051					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CGCACTGGAGGAGAGCGCGGA	0.701000													144	120					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680609	114680609	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:114680609C>T	ENST00000393296.1	-	3	656	c.579G>A	c.(577-579)gaG>gaA	p.E193E	SYT6_ENST00000369547.1_Silent_p.E108E			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	193					acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGTGGAAGCTCATTGCCAT	0.597000													12	51					0	0	1	0	0
SLC9B2	133308	broad.mit.edu	37	4	103988684	103988684	+	Silent	SNP	A	A	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:103988684A>T	ENST00000394785.3	-	2	655	c.24T>A	c.(22-24)atT>atA	p.I8I	SLC9B2_ENST00000362026.3_Silent_p.I8I|SLC9B2_ENST00000503103.1_Silent_p.I8I|SLC9B2_ENST00000505838.1_5'UTR|SLC9B2_ENST00000339611.4_Silent_p.I8I|SLC9B2_ENST00000503230.1_Silent_p.I8I	NM_178833.4	NP_849155.2	Q86UD5	NHDC2_HUMAN	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	8					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity										CTTCATATGTAATTCTTTTAT	0.353000													21	23					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962701	69962701	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:69962701C>T	ENST00000305231.7	+	1	509	c.463C>T	c.(463-465)Ccc>Tcc	p.P155S	UGT2B7_ENST00000508661.1_Missense_Mutation_p.P155S|UGT2B7_ENST00000509763.1_Intron	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	155					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGCTATTTTTCCCTGTAGTGA	0.358000													63	51					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44691282	44691282	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:44691282G>A	ENST00000290231.6	-	8	1561	c.1397C>T	c.(1396-1398)tCc>tTc	p.S466F		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	466	Transcription activation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				TGCTGCTGTGGAAAAATTCTG	0.542000													30	248					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119903607	119903607	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:119903607C>T	ENST00000313400.4	-	4	1266	c.1166G>A	c.(1165-1167)cGa>cAa	p.R389Q	ASTN2_ENST00000361209.2_Intron|ASTN2_ENST00000361477.3_Intron|ASTN2_ENST00000373996.3_Missense_Mutation_p.R389Q			O75129	ASTN2_HUMAN	astrotactin 2	389						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GGGCCTACCTCGAGACTTGCT	0.572000													33	14					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79025306	79025306	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:79025306A>T	ENST00000446378.2	+	2	749	c.718A>T	c.(718-720)Att>Ttt	p.I240F		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	240						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGAAGAATTAATTCCTCTACA	0.313000													9	29					0	0	1	0	0
MKNK1	8569	broad.mit.edu	37	1	47048920	47048920	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:47048920G>A	ENST00000371946.4	-	3	279	c.116C>T	c.(115-117)tCc>tTc	p.S39F	MKNK1_ENST00000545730.1_Missense_Mutation_p.S39F|MKNK1_ENST00000428112.2_Missense_Mutation_p.S39F|MKNK1_ENST00000371945.4_Missense_Mutation_p.S39F|MKNK1_ENST00000341183.5_Missense_Mutation_p.S39F|MKNK1_ENST00000371944.4_5'UTR|MKNK1_ENST00000465783.1_Missense_Mutation_p.S39F	NM_003684.5	NP_003675.2	Q9BUB5	MKNK1_HUMAN	MAP kinase interacting serine/threonine kinase 1	39					intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	13	Acute lymphoblastic leukemia(166;0.155)					TCCTGGCAAGGAGTCAGTGGC	0.572000													27	131					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	36917621	36917621	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:36917621C>T	ENST00000310758.4	-	19	2463	c.1816G>A	c.(1816-1818)Gac>Aac	p.D606N	ELMO1_ENST00000448602.1_Missense_Mutation_p.D606N|ELMO1_ENST00000442504.1_Missense_Mutation_p.D606N|ELMO1_ENST00000341056.3_Missense_Mutation_p.D308N|ELMO1_ENST00000396045.3_Missense_Mutation_p.D126N|ELMO1_ENST00000396040.2_Missense_Mutation_p.D126N	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	606	PH.				actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TTACGTTTGTCCTGCAAGGAA	0.478000													19	17					0	0	1	0	0
SLC13A3	64849	broad.mit.edu	37	20	45217804	45217804	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:45217804G>A	ENST00000279027.4	-	7	1029	c.1011C>T	c.(1009-1011)ccC>ccT	p.P337P	SLC13A3_ENST00000290317.5_Silent_p.P290P|SLC13A3_ENST00000413164.2_Silent_p.P287P|SLC13A3_ENST00000435032.1_5'UTR|SLC13A3_ENST00000396360.1_Silent_p.P290P|SLC13A3_ENST00000495082.1_Silent_p.P290P|SLC13A3_ENST00000472148.1_Silent_p.P290P|SLC13A3_ENST00000372121.1_Silent_p.P287P	NM_001193342.1|NM_022829.5	NP_001180271.1|NP_073740.2	Q8WWT9	S13A3_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	337						integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CATACTTGATGGGCCCCAGGT	0.527000													33	94					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38885135	38885135	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:38885135G>A	ENST00000359357.3	+	67	9864	c.9610G>A	c.(9610-9612)Gat>Aat	p.D3204N	DNAH8_ENST00000441566.1_Missense_Mutation_p.D3168N|DNAH8_ENST00000449981.2_Missense_Mutation_p.D3421N					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGTTACTATGGATCCAGAAAA	0.398000													27	91					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343714	248343714	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:248343714C>T	ENST00000359682.2	+	1	427	c.427C>T	c.(427-429)Ctt>Ttt	p.L143F		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AATTTGTGGACTTATGGCTAC	0.428000													268	150					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177100651	177100651	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:177100651C>T	ENST00000393643.2	+	30	4070	c.3818C>T	c.(3817-3819)tCc>tTc	p.S1273F	WDR17_ENST00000507824.2_Missense_Mutation_p.S1272F|WDR17_ENST00000508596.1_Missense_Mutation_p.S1258F|WDR17_ENST00000280190.4_Missense_Mutation_p.S1297F	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	1297										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TCTGCTATCTCCTTGAATGAT	0.398000													30	31					0	0	1	0	0
RGS8	85397	broad.mit.edu	37	1	182615997	182615997	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:182615997G>A	ENST00000483095.2	-	7	673	c.416C>T	c.(415-417)tCc>tTc	p.S139F	RGS8_ENST00000258302.4_Missense_Mutation_p.S157F|RGS8_ENST00000367557.4_Missense_Mutation_p.S139F|RGS8_ENST00000367556.1_Missense_Mutation_p.S139F			P57771	RGS8_HUMAN	regulator of G-protein signaling 8	139	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	5						GCAAGTCAGGGATGGCTCCTG	0.507000													41	223					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2592967	2592967	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:2592967G>T	ENST00000358864.1	+	13	1739	c.1724G>T	c.(1723-1725)tGg>tTg	p.W575L	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	575						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						GGTTCTTGCTGGGAGACAGCT	0.498000													11	114					1.61879e-10	1.65053e-10	1	1	0
TTN	7273	broad.mit.edu	37	2	179637853	179637853	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:179637853C>T	ENST00000589042.1	-	33	8062	c.7838G>A	c.(7837-7839)gGa>gAa	p.G2613E	TTN-AS1_ENST00000584485.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G2613E|TTN_ENST00000342175.6_Missense_Mutation_p.G2567E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G2567E|TTN_ENST00000360870.5_Missense_Mutation_p.G2613E|TTN_ENST00000460472.2_Missense_Mutation_p.G2567E|TTN_ENST00000342992.6_Missense_Mutation_p.G2613E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2347							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTAAGTTTTCCAGATGTCAT	0.299000													21	46					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91348402	91348402	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:91348402G>A	ENST00000358859.2	-	1	551	c.118C>T	c.(118-120)Cga>Tga	p.R40*	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		GGGCGCCTTCGATGGCAGGAC	0.667000													7	26					0	0	1	0	0
ORC2	4999	broad.mit.edu	37	2	201798673	201798673	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:201798673C>T	ENST00000234296.2	-	10	982	c.733G>A	c.(733-735)Gaa>Aaa	p.E245K		NM_006190.4	NP_006181.1	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	245					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	20						CTGTGAGCTTCAAAATATTCT	0.343000													12	44					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31323206	31323206	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:31323206G>A	ENST00000265071.2	+	12	2429	c.2164G>A	c.(2164-2166)Gaa>Aaa	p.E722K		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	722					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.E722K(2)		NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AAGGTTAAAGGAAAATGACAC	0.562000													5	65					0	0	1	0	0
MESDC2	23184	broad.mit.edu	37	15	81271619	81271619	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:81271619G>A	ENST00000261758.4	-	3	732	c.646C>T	c.(646-648)Ctg>Ttg	p.L216L		NM_015154.1	NP_055969.1	Q14696	MESD_HUMAN	mesoderm development candidate 2	216					mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum				cervix(1)|large_intestine(5)|ovary(1)|urinary_tract(1)	8						CGAGATTTCAGATCTCCTTCC	0.498000													16	42					0	0	1	0	0
REG3A	5068	broad.mit.edu	37	2	79384407	79384407	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:79384407C>T	ENST00000393878.1	-	5	727	c.473G>A	c.(472-474)tGg>tAg	p.W158*	REG3A_ENST00000305165.2_Nonsense_Mutation_p.W158*|REG3A_ENST00000409839.3_Nonsense_Mutation_p.W158*	NM_138938.2	NP_620355.1	Q06141	REG3A_HUMAN	regenerating islet-derived 3 alpha	158	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			breast(2)|large_intestine(4)|lung(41)|prostate(2)|skin(1)	50						ATAATCTTTCCACCTCAGAAA	0.458000													12	39					0	0	1	0	0
FAM98C	147965	broad.mit.edu	37	19	38899451	38899451	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:38899451C>T	ENST00000252530.5	+	8	998	c.979C>T	c.(979-981)Ccc>Tcc	p.P327S	FAM98C_ENST00000588262.1_3'UTR|FAM98C_ENST00000343358.7_Missense_Mutation_p.P245S	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	327										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCCTCCCATGCCCACCTGGAG	0.577000													39	58					0	0	1	0	0
VEPH1	79674	broad.mit.edu	37	3	157188163	157188163	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:157188163C>T	ENST00000362010.2	-	3	601	c.294G>A	c.(292-294)ggG>ggA	p.G98G	VEPH1_ENST00000537559.1_Silent_p.G98G|VEPH1_ENST00000543418.1_Silent_p.G98G|VEPH1_ENST00000392833.2_Silent_p.G98G|VEPH1_ENST00000494677.1_Silent_p.G98G|VEPH1_ENST00000468233.1_Silent_p.G98G|VEPH1_ENST00000392832.2_Silent_p.G98G	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	98						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CTTCGTCTTTCCCAAAGGGTC	0.458000													42	23					0	0	1	0	0
C12orf4	57102	broad.mit.edu	37	12	4600388	4600388	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:4600388G>A	ENST00000261250.3	-	12	1540	c.1453C>T	c.(1453-1455)Ccc>Tcc	p.P485S	C12orf4_ENST00000545746.1_Missense_Mutation_p.P485S	NM_020374.2	NP_065107.1	Q9NQ89	CL004_HUMAN	chromosome 12 open reading frame 4	485										NS(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		AAGCACCAGGGTATAGTCATT	0.348000													23	71					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150528791	150528791	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:150528791G>A	ENST00000271643.4	+	9	1761	c.1525G>A	c.(1525-1527)Gga>Aga	p.G509R	RP11-54A4.2_ENST00000442435.2_RNA|ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.G509R|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.G532R|ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.G509R	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	509					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GATTCCAGCGGGAGCCTTGCG	0.617000													20	127					0	0	1	0	0
PCOLCE	5118	broad.mit.edu	37	7	100204230	100204230	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:100204230C>A	ENST00000223061.5	+	6	1197	c.917C>A	c.(916-918)aCa>aAa	p.T306K		NM_002593.3	NP_002584.2	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	306					multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCGGAGAAAACAGAGGAATCT	0.597000													21	43					1.22574e-08	1.23936e-08	1	1	0
LILRB2	10288	broad.mit.edu	37	19	54783386	54783386	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:54783386C>T	ENST00000391748.1	-	5	599	c.472G>A	c.(472-474)Gaa>Aaa	p.E158K	LILRB2_ENST00000391749.4_Missense_Mutation_p.E158K|LILRB2_ENST00000434421.1_Missense_Mutation_p.E42K|LILRB2_ENST00000314446.5_Missense_Mutation_p.E158K|LILRB2_ENST00000391746.1_Missense_Mutation_p.E158K	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	158	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity	p.E158*(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTTCTCCTTCCTTACACAGA	0.622000													50	115					0	0	1	0	0
KIF2A	3796	broad.mit.edu	37	5	61648531	61648531	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:61648531C>T	ENST00000381103.2	+	6	876	c.391C>T	c.(391-393)Ccc>Tcc	p.P131S	KIF2A_ENST00000506857.1_Intron|KIF2A_ENST00000401507.3_Missense_Mutation_p.P151S|KIF2A_ENST00000509663.2_Intron|KIF2A_ENST00000407818.3_Missense_Mutation_p.P151S	NM_001243952.1	NP_001230881.1	O00139	KIF2A_HUMAN	kinesin heavy chain member 2A	151	Globular (Potential).				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	15		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		GGAATTTGGACCCCCTTGTAT	0.388000													5	11					0	0	1	0	0
MTG2	26164	broad.mit.edu	37	20	60775992	60775992	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:60775992G>A	ENST00000370823.3	+	7	1098	c.1080G>A	c.(1078-1080)cgG>cgA	p.R360R	MTG2_ENST00000536470.1_Silent_p.R132R|MTG2_ENST00000436421.2_Silent_p.R202R	NM_015666.3	NP_056481.1			mitochondrial ribosome-associated GTPase 2																		CCCAGCTCCGGGATCACTTGG	0.587000													50	37					0	0	1	0	0
RP11-257K9.8	0	broad.mit.edu	37	6	73919804	73919804	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:73919804C>T	ENST00000423730.3	-	8	1301		c.e8-1																									CTGCTCTGACCTGATTCAGAA	0.473000													5	14					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40318449	40318449	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:40318449G>A	ENST00000264661.3	-	10	2038	c.1706C>T	c.(1705-1707)tCg>tTg	p.S569L	KCNH4_ENST00000607371.1_Missense_Mutation_p.S569L	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	569					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GATGTGCAGCGATAGGGCCCG	0.627000													9	36					0	0	1	0	0
TUFM	7284	broad.mit.edu	37	16	28855288	28855288	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:28855288G>A	ENST00000313511.3	-	8	1195	c.1057C>T	c.(1057-1059)Cag>Tag	p.Q353*	MIR4721_ENST00000577590.1_RNA	NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	350						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						TCCACCTTCTGGTGGGGCTTG	0.662000													17	33					0	0	1	0	0
SEPT5	5413	broad.mit.edu	37	22	19707891	19707891	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:19707891C>T	ENST00000438754.2	+	5	718	c.438C>T	c.(436-438)ttC>ttT	p.F146F	SEPT5_ENST00000455784.2_Silent_p.F137F|SEPT5_ENST00000406395.1_Silent_p.F137F|SEPT5_ENST00000383045.3_Silent_p.F146F	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	137					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					AGCAGTACTTCCGTGATGAGA	0.597000													46	51					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137485337	137485337	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:137485337G>A	ENST00000254900.5	-	23	3641	c.3270C>T	c.(3268-3270)tcC>tcT	p.S1090S		NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	1090					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ACAGCTTTGAGGAGGTAGCAT	0.408000													15	23					0	0	1	0	0
RACGAP1	29127	broad.mit.edu	37	12	50388291	50388291	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:50388291C>T	ENST00000434422.1	-	12	1347	c.1044_splice	c.e12-1	p.G349_splice	RACGAP1_ENST00000454520.2_Splice_Site_p.G349_splice|RACGAP1_ENST00000427314.2_Splice_Site_p.G349_splice|RACGAP1_ENST00000551016.1_Splice_Site_p.G349_splice|RACGAP1_ENST00000312377.5_Splice_Site_p.G349_splice|RACGAP1_ENST00000547905.1_Splice_Site_p.G349_splice			Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	349	Rho-GAP.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(6)	14						TGCCAGCATTCCCTGGAAAAA	0.413000													20	35					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149544996	149544996	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:149544996C>T	ENST00000223210.4	+	4	659	c.414C>T	c.(412-414)tcC>tcT	p.S138S		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						AGCCCCGGTCCATCCAGAAGT	0.557000													10	15					0	0	1	0	0
PRR14	78994	broad.mit.edu	37	16	30666434	30666434	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:30666434G>A	ENST00000542965.2	+	7	1599	c.1143G>A	c.(1141-1143)cgG>cgA	p.R381R	PRR14_ENST00000571654.1_Intron|PRR14_ENST00000300835.4_Silent_p.R381R			Q9BWN1	PRR14_HUMAN	proline rich 14	381										breast(3)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	18			Colorectal(24;0.103)			CCTGTCTCCGGAAAGAGGTCT	0.662000													44	94					0	0	1	0	0
ZNF611	81856	broad.mit.edu	37	19	53208331	53208331	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:53208331G>A	ENST00000543227.1	-	6	2251	c.1977C>T	c.(1975-1977)ttC>ttT	p.F659F	ZNF611_ENST00000453741.2_Silent_p.F590F|ZNF611_ENST00000319783.1_Silent_p.F659F|ZNF611_ENST00000540744.1_Silent_p.F659F|ZNF611_ENST00000595798.1_Silent_p.F590F|ZNF611_ENST00000602162.1_Silent_p.F590F	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	659					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		AATTACGCACGAAAGCCTTGT	0.408000													50	94					0	0	1	0	0
LOC494141	494141	broad.mit.edu	37	11	18231460	18231460	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:18231460G>A	ENST00000527059.1	+	1	706	c.246G>A	c.(244-246)acG>acA	p.T82T	RP11-113D6.10_ENST00000340135.3_Silent_p.T82T|RP11-113D6.10_ENST00000534640.1_Silent_p.T82T																							AGTTGAGAACGGATGGATTTC	0.448000													27	17					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31383818	31383818	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:31383818C>T	ENST00000268296.4	+	18	2401	c.2280C>T	c.(2278-2280)taC>taT	p.Y760Y	ITGAX_ENST00000562522.1_Silent_p.Y760Y	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	760					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CTCAGAGATACTTCACGGCCT	0.632000													22	39					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154112301	154112301	+	Nonsense_Mutation	SNP	G	G	A	rs142024728		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:154112301G>A	ENST00000368559.3	-	5	765	c.694C>T	c.(694-696)Cga>Tga	p.R232*	NUP210L_ENST00000271854.3_Nonsense_Mutation_p.R232*	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	232						integral to membrane		p.R232*(1)		NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TCATGAATTCGAACTTTTACA	0.368000													48	327					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123301320	123301320	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:123301320G>A	ENST00000296513.2	+	3	281	c.96G>A	c.(94-96)acG>acA	p.T32T	ADAD1_ENST00000388725.2_Silent_p.T14T|ADAD1_ENST00000388724.2_Silent_p.T32T	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	32					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						CGACAAAGACGATAACTACAC	0.468000													27	45					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43766122	43766122	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:43766122C>T	ENST00000244293.7	-	3	665	c.599G>A	c.(598-600)aGg>aAg	p.R200K	PSG9_ENST00000443718.3_Intron|PSG9_ENST00000593948.1_Missense_Mutation_p.R200K|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000291752.5_Intron|PSG9_ENST00000270077.3_Missense_Mutation_p.R200K			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	200	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				ATAGAGGGTCCTGTTGGTTTT	0.498000													108	315					0	0	1	0	0
ACSM1	116285	broad.mit.edu	37	16	20648726	20648726	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:20648726G>A	ENST00000219151.4	-	8	1231	c.21C>T	c.(19-21)ttC>ttT	p.F7F	ACSM1_ENST00000307493.4_Silent_p.F388F|ACSM1_ENST00000520010.1_Silent_p.F388F			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	388					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						CCTTCCCCATGAAACCCGGCT	0.537000													35	79					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22157396	22157396	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:22157396C>G	ENST00000397126.4	-	4	588	c.440G>C	c.(439-441)cGt>cCt	p.R147P	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATATTTGCCACGTTGAAATAC	0.328000													4	86					0	0	1	0	0
PIK3CB	5291	broad.mit.edu	37	3	138417858	138417858	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:138417858T>C	ENST00000477593.1	-	12	1734	c.1661A>G	c.(1660-1662)gAa>gGa	p.E554G	PIK3CB_ENST00000289153.2_Missense_Mutation_p.E554G|PIK3CB_ENST00000544716.1_5'UTR			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	554	PI3K helical.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						AAGATCCATTTCATTTTCACA	0.383000													36	62					0	0	1	0	0
CLDN3	1365	broad.mit.edu	37	7	73184019	73184019	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:73184019C>T	ENST00000395145.2	-	1	581	c.361G>A	c.(361-363)Ggc>Agc	p.G121S		NM_001306.3	NP_001297.1	O15551	CLD3_HUMAN	claudin 3	121					response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity			kidney(1)|lung(1)	2		Lung NSC(55;0.159)				AACAGCACGCCTGCCACGATG	0.672000													24	25					0	0	1	0	0
CARD16	114769	broad.mit.edu	37	11	104915214	104915214	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:104915214G>A	ENST00000375706.2	-	2	196	c.179C>T	c.(178-180)tCc>tTc	p.S60F	CASP1_ENST00000598974.1_Intron|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000593315.1_Intron|CASP1_ENST00000594519.1_Intron|CARD16_ENST00000525374.1_Missense_Mutation_p.S60F|CARD16_ENST00000375704.3_Missense_Mutation_p.S60F	NM_001017534.1	NP_001017534.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						CGGAATAACGGAGTCAATCAA	0.448000													88	90					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139180146	139180146	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:139180146G>A	ENST00000395297.1	-	12	1420	c.1250C>T	c.(1249-1251)cCt>cTt	p.P417L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	417								p.P417L(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCTGTCGCAGGGCAGTCCAC	0.507000										HNSCC(54;0.14)			110	59					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7721773	7721773	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:7721773G>A	ENST00000572933.1	+	69	11991	c.10531G>A	c.(10531-10533)Gaa>Aaa	p.E3511K	DNAH2_ENST00000389173.2_Missense_Mutation_p.E3511K			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3511	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGCTGTTAAAGAACAGGTGGG	0.502000													53	176					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75964575	75964575	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:75964575A>C	ENST00000274364.6	+	23	3046	c.2749A>C	c.(2749-2751)Act>Cct	p.T917P	IQGAP2_ENST00000502745.1_Missense_Mutation_p.T413P|IQGAP2_ENST00000379730.3_Missense_Mutation_p.T419P|IQGAP2_ENST00000396234.3_Missense_Mutation_p.T413P	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	917	Ras-GAP.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ATTTATGGATACTGTTATTTT	0.338000													8	23					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36369813	36369813	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:36369813G>A	ENST00000221891.4	+	15	1864	c.1672G>A	c.(1672-1674)Ggt>Agt	p.G558S	APLP1_ENST00000537454.2_Missense_Mutation_p.G518S|APLP1_ENST00000586861.1_Missense_Mutation_p.G551S	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	557					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGTTCCAAGGGGTTTCCCTTT	0.602000													52	71					0	0	1	0	0
CYP2U1	113612	broad.mit.edu	37	4	108866315	108866315	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:108866315C>T	ENST00000332884.6	+	2	955	c.680C>T	c.(679-681)gCc>gTc	p.A227V	CYP2U1_ENST00000508453.1_Missense_Mutation_p.A18V|RP11-286E11.1_ENST00000513071.1_RNA	NM_183075.2	NP_898898.1	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U, polypeptide 1	227					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|large_intestine(2)|lung(4)|skin(2)|urinary_tract(1)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		ATCAGCAATGCCGTCTCTAAC	0.438000													19	97					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10304459	10304459	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:10304459C>T	ENST00000403437.2	-	25	3252	c.3158G>A	c.(3157-3159)aGa>aAa	p.R1053K	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1053					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CCGCTTTGCTCTTTCTAGATC	0.348000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				17	53					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16032718	16032718	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:16032718G>A	ENST00000350896.3	-	3	392	c.195C>T	c.(193-195)atC>atT	p.I65I	MSR1_ENST00000381998.4_Silent_p.I65I|MSR1_ENST00000262101.5_Silent_p.I65I|MSR1_ENST00000355282.2_Silent_p.I65I|MSR1_ENST00000445506.2_Silent_p.I83I|MSR1_ENST00000536385.1_Intron	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	65					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CAATGAGAGGGATGAGAACTG	0.408000													13	42					0	0	1	0	0
BAIAP2	10458	broad.mit.edu	37	17	79077849	79077849	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:79077849C>T	ENST00000321300.6	+	9	1100	c.1007C>T	c.(1006-1008)tCc>tTc	p.S336F	BAIAP2_ENST00000575245.1_Missense_Mutation_p.S369F|BAIAP2_ENST00000321280.7_Missense_Mutation_p.S336F|BAIAP2_ENST00000392411.3_Missense_Mutation_p.S258F|BAIAP2_ENST00000435091.3_Missense_Mutation_p.S336F|BAIAP2_ENST00000428708.2_Missense_Mutation_p.S336F|BAIAP2_ENST00000575712.1_Missense_Mutation_p.S336F|BAIAP2_ENST00000416299.2_Missense_Mutation_p.S199F	NM_001144888.1|NM_017451.2	NP_001138360.1|NP_059345.1	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2	336					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)	18	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CTCAGCGACTCCTACTCCAAC	0.637000													21	77					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85446650	85446650	+	Missense_Mutation	SNP	G	G	A	rs149453199		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:85446650G>A	ENST00000369663.5	-	8	1914	c.1577C>T	c.(1576-1578)cCc>cTc	p.P526L	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	526					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		TAGTGCACAGGGGCTGTGTAA	0.493000													35	148					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73800220	73800220	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:73800220C>T	ENST00000264448.6	+	16	11324	c.11213C>T	c.(11212-11214)cCc>cTc	p.P3738L	ALMS1_ENST00000409009.1_Missense_Mutation_p.P3696L	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3738					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GATTGTCGGCCCTCAGAGGAG	0.378000													28	40					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42204018	42204018	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:42204018G>A	ENST00000541110.1	-	16	3619	c.3051C>T	c.(3049-3051)ccC>ccT	p.P1017P	TRERF1_ENST00000354325.2_Silent_p.P914P|TRERF1_ENST00000372917.4_Silent_p.P914P|TRERF1_ENST00000340840.2_Silent_p.P914P|TRERF1_ENST00000372922.4_Silent_p.P997P			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	997	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCCCCTCCGTGGGAGCCAGGA	0.627000													10	21					0	0	1	0	0
ZFP28	140612	broad.mit.edu	37	19	57065806	57065806	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:57065806A>G	ENST00000301318.3	+	8	1723	c.1652A>G	c.(1651-1653)cAt>cGt	p.H551R	AC007228.11_ENST00000596587.1_RNA	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		CTTACTGTACATCAAAGGATT	0.393000													11	59					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48456644	48456644	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:48456644T>A	ENST00000358536.4	-	20	4176	c.3907A>T	c.(3907-3909)Agg>Tgg	p.R1303W	PLXNB1_ENST00000358459.4_Missense_Mutation_p.R1120W|PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000465117.1_5'UTR|PLXNB1_ENST00000456774.1_Missense_Mutation_p.R1120W|PLXNB1_ENST00000296440.6_Missense_Mutation_p.R1303W	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1303	IPT/TIG 3.|Poly-Arg.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACGCGACGCCTCCGTCCAAGC	0.637000													8	62					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133844271	133844271	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:133844271G>A	ENST00000367895.5	+	18	2158	c.1694G>A	c.(1693-1695)gGa>gAa	p.G565E	EYA4_ENST00000525849.1_Missense_Mutation_p.G542E|EYA4_ENST00000452339.2_Missense_Mutation_p.G511E|EYA4_ENST00000430974.2_Missense_Mutation_p.G517E|EYA4_ENST00000531901.1_Missense_Mutation_p.G571E|EYA4_ENST00000355286.6_Missense_Mutation_p.G542E|EYA4_ENST00000431403.2_Missense_Mutation_p.G565E|EYA4_ENST00000355167.3_Missense_Mutation_p.G565E|RP3-323P13.2_ENST00000607033.1_RNA	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	565					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TATAGTTTAGGAGGTGCTTTC	0.383000													21	35					0	0	1	0	0
FAM53A	152877	broad.mit.edu	37	4	1656958	1656958	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:1656958G>A	ENST00000308132.6	-	4	821	c.629C>T	c.(628-630)tCc>tTc	p.S210F	FAM53A_ENST00000489363.1_Missense_Mutation_p.S210F|FAM53A_ENST00000461064.1_Missense_Mutation_p.S210F|FAM53A_ENST00000472884.2_Missense_Mutation_p.S210F	NM_001174070.1	NP_001167541.1	Q6NSI3	FA53A_HUMAN	family with sequence similarity 53, member A	210						nucleus				breast(2)|central_nervous_system(2)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			GGACTCCGCGGAACACCAGAG	0.761000													3	10					0	0	1	0	0
ZNF628	89887	broad.mit.edu	37	19	55992908	55992908	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:55992908C>T	ENST00000598519.1	+	3	901	c.348C>T	c.(346-348)ggC>ggT	p.G116G	ZNF628_ENST00000391718.2_Silent_p.G112G	NM_033113.2	NP_149104.3	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	112						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		TGCACACCGGCCTGCGGGCCT	0.667000													5	34					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8331706	8331706	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:8331706G>A	ENST00000381196.4	-	41	5953	c.5410C>T	c.(5410-5412)Cag>Tag	p.Q1804*	PTPRD_ENST00000397611.3_Nonsense_Mutation_p.Q1394*|PTPRD_ENST00000397617.3_Nonsense_Mutation_p.Q1397*|PTPRD_ENST00000540109.1_Nonsense_Mutation_p.Q1804*|PTPRD_ENST00000360074.4_Nonsense_Mutation_p.Q1791*|PTPRD_ENST00000537002.1_Nonsense_Mutation_p.Q1394*|PTPRD_ENST00000358503.5_Nonsense_Mutation_p.Q1782*|PTPRD_ENST00000486161.1_Nonsense_Mutation_p.Q1397*|PTPRD_ENST00000356435.5_Nonsense_Mutation_p.Q1804*|PTPRD_ENST00000355233.5_Nonsense_Mutation_p.Q1398*|PTPRD_ENST00000397606.3_Nonsense_Mutation_p.Q1397*	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1804	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCAGTGAACTGGAACTGCCTT	0.512000										TSP Lung(15;0.13)			44	28					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3614067	3614067	+	RNA	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:3614067C>T	ENST00000301749.7	-	0	1276				NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000419350.2_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ATCTCCTCCTCGTTAAAGCCC	0.607000													32	56					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642767	57642767	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:57642767C>T	ENST00000254181.4	+	4	3178	c.2724C>T	c.(2722-2724)atC>atT	p.I908I	USP29_ENST00000598197.1_Silent_p.I908I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	908					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAGGGGTGATCCCTCAGGGGG	0.473000													31	65					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	327884	327884	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:327884G>A	ENST00000264819.4	-	4	359	c.349C>T	c.(349-351)Cca>Tca	p.P117S	MIER2_ENST00000592722.1_5'UTR	NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCATGTCTGGGAGGTTCGGG	0.617000													12	25					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69552686	69552686	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:69552686C>T	ENST00000337103.4	+	7	2440	c.848C>T	c.(847-849)cCt>cTt	p.P283L	C8orf34_ENST00000325233.3_Missense_Mutation_p.P52L|C8orf34_ENST00000539993.1_Missense_Mutation_p.P308L|C8orf34_ENST00000518698.1_Missense_Mutation_p.P394L			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	308					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CAAGGCCGTCCTACTTACCCT	0.413000													7	67					0	0	1	0	0
TNFRSF10A	8797	broad.mit.edu	37	8	23049444	23049444	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:23049444C>T	ENST00000221132.3	-	10	1234	c.1170G>A	c.(1168-1170)acG>acA	p.T390T		NM_003844.3	NP_003835.3	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily, member 10a	390	Death.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			NS(2)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|skin(1)	16		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TCTCATTTTTCGTGAGGTCCA	0.522000													29	40					0	0	1	0	0
KLK9	284366	broad.mit.edu	37	19	51507069	51507069	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:51507069G>A	ENST00000250366.6	-	4	527	c.494C>T	c.(493-495)gCc>gTc	p.A165V	KLK9_ENST00000594211.1_Missense_Mutation_p.A165V|CTB-147C22.9_ENST00000594512.1_RNA|KLK9_ENST00000376832.4_Missense_Mutation_p.A165V	NM_012315.1	NP_036447.1	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9	165	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		GCTGATGTTGGCACACTGCAG	0.577000													34	32					0	0	1	0	0
ADH1C	126	broad.mit.edu	37	4	100257910	100257910	+	RNA	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:100257910C>T	ENST00000515683.1	-	0	1478					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	TGTATTGTTTCAAAACGTCAG	0.418000													18	20					0	0	1	0	0
MVB12A	93343	broad.mit.edu	37	19	17533153	17533153	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:17533153C>T	ENST00000317040.7	+	4	1354	c.299C>T	c.(298-300)tCc>tTc	p.S100F	MVB12A_ENST00000543795.1_Missense_Mutation_p.S100F|MVB12A_ENST00000529939.1_Missense_Mutation_p.S100F|MVB12A_ENST00000392702.2_Missense_Mutation_p.S100F|MVB12A_ENST00000528515.1_Intron					multivesicular body subunit 12A																		GCCTCTGTGTCCAAGAAGAAA	0.607000													32	50					0	0	1	0	0
KRTAP5-9	3846	broad.mit.edu	37	11	71259856	71259856	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:71259856C>T	ENST00000528743.2	+	1	391	c.153C>T	c.(151-153)gcC>gcT	p.A51A		NM_005553.3	NP_005544.4	P26371	KRA59_HUMAN	keratin associated protein 5-9	51	8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament				kidney(1)|large_intestine(1)|lung(6)|prostate(3)	11						GTGTTCCAGCCTGTTCCTGCT	0.647000													131	94					0	0	1	0	0
TAGAP	117289	broad.mit.edu	37	6	159457437	159457437	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:159457437G>A	ENST00000367066.3	-	10	1949	c.1618C>T	c.(1618-1620)Ccg>Tcg	p.P540S	RP1-111C20.4_ENST00000606466.1_RNA|TAGAP_ENST00000326965.6_Missense_Mutation_p.P362S|RP1-111C20.4_ENST00000606470.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000607391.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	540					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		ACACCCCTCGGGACGTGGTCC	0.562000													36	43					0	0	1	0	0
SEC16B	89866	broad.mit.edu	37	1	177905472	177905472	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:177905472G>A	ENST00000308284.6	-	20	2621	c.2532C>T	c.(2530-2532)tcC>tcT	p.S844S	RP4-798P15.3_ENST00000354921.2_5'UTR|SEC16B_ENST00000495165.1_5'UTR|RP4-798P15.3_ENST00000528461.1_3'UTR	NM_033127.2	NP_149118.2	Q96JE7	SC16B_HUMAN	SEC16 homolog B (S. cerevisiae)	844					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)|stomach(1)	35						CAGGAGGCTGGGAAGTTTCTT	0.458000													3	17					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39577166	39577166	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:39577166C>T	ENST00000225550.3	-	7	1313	c.1314G>A	c.(1312-1314)ggG>ggA	p.G438G	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	438	Tail.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				CAGAGGGAGACCCACCGGTGA	0.577000													9	31					0	0	1	0	0
PAQR3	152559	broad.mit.edu	37	4	79841703	79841703	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:79841703G>A	ENST00000512733.1	-	6	1139	c.926C>T	c.(925-927)tCa>tTa	p.S309L	PAQR3_ENST00000515541.1_Intron|PAQR3_ENST00000295462.3_3'UTR	NM_001040202.1	NP_001035292.1	Q6TCH7	PAQR3_HUMAN	progestin and adipoQ receptor family member III	309						Golgi membrane|integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	8						TCACAAATGTGAAACATAGTC	0.383000													4	81					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121384959	121384959	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:121384959G>A	ENST00000260197.7	+	8	1269	c.1140G>A	c.(1138-1140)ctG>ctA	p.L380L	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	380					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CAGAGGGGCTGAAGTTCTCCC	0.537000													28	17					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112969738	112969738	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:112969738C>T	ENST00000485230.1	+	4	1059	c.434C>T	c.(433-435)cCt>cTt	p.P145L	BOC_ENST00000355385.3_Intron|BOC_ENST00000484034.1_Missense_Mutation_p.P145L|BOC_ENST00000495514.1_Intron|BOC_ENST00000273395.4_Intron			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	0	Ig-like C2-type 2.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			CTCTCCCACCCTGAAGCCCCC	0.557000													4	13					0	0	1	0	0
IGLV1-47	28822	broad.mit.edu	37	22	22712403	22712403	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:22712403G>A	ENST00000390294.2	+	0	202																											TCCAACATCGGAAGTAATTAT	0.577000													179	141					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72943535	72943535	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:72943535G>A	ENST00000328801.4	+	6	1585	c.1585G>A	c.(1585-1587)Gag>Aag	p.E529K		NM_178233.1	NP_839947.1	Q7RTS5	OTOP3_HUMAN	otopetrin 3	529						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					GGCACTCAAGGAGATCTCACT	0.607000													17	38					0	0	1	0	0
BDKRB1	623	broad.mit.edu	37	14	96730546	96730546	+	Missense_Mutation	SNP	G	G	A	rs145002930		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:96730546G>A	ENST00000216629.6	+	3	1133	c.527G>A	c.(526-528)cGa>cAa	p.R176Q	BDKRB1_ENST00000553356.1_Missense_Mutation_p.R176Q|RP11-404P21.3_ENST00000553638.1_RNA	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	176					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		TTCCTGCTGCGATCCATCCAA	0.612000													19	47					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38939031	38939031	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:38939031C>T	ENST00000355481.4	+	10	968	c.837C>T	c.(835-837)ctC>ctT	p.L279L	RYR1_ENST00000360985.3_Silent_p.L279L|RYR1_ENST00000359596.3_Silent_p.L279L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	279	MIR 4.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCCAGCCACTCCGAGTCCGGC	0.642000													41	123					0	0	1	0	0
APLP1	333	broad.mit.edu	37	19	36369836	36369836	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:36369836G>A	ENST00000221891.4	+	15	1887	c.1695G>A	c.(1693-1695)gaG>gaA	p.E565E	APLP1_ENST00000537454.2_Silent_p.E525E|APLP1_ENST00000586861.1_Silent_p.E558E	NM_001024807.1|NM_005166.3	NP_001019978.1|NP_005157.1	P51693	APLP1_HUMAN	amyloid beta (A4) precursor-like protein 1	564					apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	33	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACTCATCGGAGATTCAGAGGG	0.582000													21	83					0	0	1	0	0
GATSL3	652968	broad.mit.edu	37	22	30681833	30681833	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:30681833G>A	ENST00000407689.3	-	8	1038	c.909C>T	c.(907-909)ttC>ttT	p.F303F	RP1-130H16.18_ENST00000447976.1_3'UTR|GATSL3_ENST00000459785.1_Intron|GATSL3_ENST00000404953.3_Silent_p.F265F	NM_001037666.2	NP_001032755.1			GATS protein-like 3											breast(1)|endometrium(1)|lung(1)	3						GGGCGTGGTCGAAGTTGAAGG	0.607000													10	12					0	0	1	0	0
GCSAML	148823	broad.mit.edu	37	1	247712498	247712498	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:247712498G>A	ENST00000366491.2	+	4	502	c.5G>A	c.(4-6)gGa>gAa	p.G2E	GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000536561.1_Missense_Mutation_p.G2E|GCSAML_ENST00000366489.1_Missense_Mutation_p.G2E|GCSAML_ENST00000366488.4_Missense_Mutation_p.G2E|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000463359.1_Intron|GCSAML_ENST00000366490.3_Missense_Mutation_p.E123K					germinal center-associated, signaling and motility-like																		GAAAAGATGGGAAATTATCTC	0.483000													17	96					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074858	9074858	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9074858C>T	ENST00000397910.4	-	3	12791	c.12588G>A	c.(12586-12588)gaG>gaA	p.E4196E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4198	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCCAGAGGTCTCAGACAAGA	0.498000													18	33					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37770712	37770712	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:37770712G>A	ENST00000402918.1	-	3	1648	c.863C>T	c.(862-864)tCg>tTg	p.S288L	RP1-63G5.5_ENST00000430883.1_RNA|ELFN2_ENST00000349653.3_Missense_Mutation_p.S288L	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	288						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					CGTGGTGGACGAGGCCGGCGG	0.662000													47	177					0	0	1	0	0
MIR411	693121	broad.mit.edu	37	14	101489752	101489752	+	RNA	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:101489752C>T	ENST00000362239.2	+	0	91					NR_030389.1																						CAAATCCATCCCCGAGGCTCC	0.502000													5	23					0	0	1	0	0
SBSPON	157869	broad.mit.edu	37	8	73979628	73979628	+	Missense_Mutation	SNP	C	C	T	rs149127771	by1000genomes	TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:73979628C>T	ENST00000297354.6	-	5	947	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	SBSPON_ENST00000519697.1_5'UTR	NM_153225.3	NP_694957.3	Q8IVN8	RPESP_HUMAN	somatomedin B and thrombospondin, type 1 domain containing	248					immune response	extracellular region	polysaccharide binding|scavenger receptor activity										GTCTACTCGCCGAACTTTTTT	0.343000													6	79					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21217208	21217208	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:21217208C>A	ENST00000380216.1	-	1	102	c.97G>T	c.(97-99)Ggt>Tgt	p.G33C		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	33					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding	p.G33C(1)		central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		CTCCTATTACCCAGGCTGTGA	0.512000													33	141					3.67414e-24	3.78327e-24	1	1	0
SFTA3	253970	broad.mit.edu	37	14	36946289	36946289	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:36946289C>T	ENST00000518529.2	-	3	823	c.148G>A	c.(148-150)Gaa>Aaa	p.E50K	SFTA3_ENST00000518987.1_Intron|RP11-896J10.3_ENST00000521945.1_RNA	NM_001101341.1	NP_001094811.1	P0C7M3	SFTA3_HUMAN	surfactant associated 3	50										breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7						ATCCGCTTTTCCCTCTCCCTC	0.522000													30	43					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164518	139164518	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:139164518C>T	ENST00000395297.1	-	13	2370	c.2200G>A	c.(2200-2202)Gaa>Aaa	p.E734K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	734										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTGTTACTTTCTGTGTGTCCA	0.542000										HNSCC(54;0.14)			13	66					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179516620	179516620	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:179516620G>A	ENST00000589042.1	-	205	39594	c.39370C>T	c.(39370-39372)Cct>Tct	p.P13124S	TTN_ENST00000591111.1_Missense_Mutation_p.P11617S|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P10690S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11477	Ig-like 87.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTGTGGAGGCGCCGCTGGC	0.512000													4	8					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7793966	7793966	+	Silent	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:7793966C>A	ENST00000380358.4	+	3	469	c.468C>A	c.(466-468)acC>acA	p.T156T	CHD3_ENST00000570758.1_3'UTR|CHD3_ENST00000330494.7_Silent_p.T97T|CHD3_ENST00000358181.4_Silent_p.T97T	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	97					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				AATATGGAACCGGACCGGGTC	0.493000													8	8					1.12685e-05	1.13464e-05	1	1	0
LAMA3	3909	broad.mit.edu	37	18	21338406	21338406	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:21338406C>T	ENST00000313654.9	+	7	1235	c.994C>T	c.(994-996)Cgc>Tgc	p.R332C	LAMA3_ENST00000399516.3_Missense_Mutation_p.R332C	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	332	Domain V.|Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GACGTGTGATCGCTGCTGCAC	0.597000													3	30					0	0	1	0	0
HELB	92797	broad.mit.edu	37	12	66725159	66725159	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:66725159C>T	ENST00000247815.4	+	12	2955	c.2896C>T	c.(2896-2898)Ccg>Tcg	p.P966S		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	966			P -> L (in dbSNP:rs1185244).		DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AGCAGATTTTCCGTCCCCACG	0.502000													32	44					0	0	1	0	0
GNE	10020	broad.mit.edu	37	9	36218285	36218285	+	Silent	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:36218285A>G	ENST00000396594.3	-	11	2032	c.1921T>C	c.(1921-1923)Ttg>Ctg	p.L641L	GNE_ENST00000539208.1_Silent_p.L500L|GNE_ENST00000447283.2_Silent_p.L536L|GNE_ENST00000377902.5_Silent_p.L610L|GNE_ENST00000539815.1_Silent_p.L610L|GNE_ENST00000543356.2_Silent_p.L605L	NM_001128227.2	NP_001121699.1	Q9Y223	GLCNE_HUMAN	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	610	N-acetylmannosamine kinase.				cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			STAD - Stomach adenocarcinoma(86;0.228)			CCTTCCACCAAGAGCAGGTCC	0.547000													22	72					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	95022258	95022258	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:95022258C>T	ENST00000357742.4	+	22	2632	c.2632C>T	c.(2632-2634)Ctc>Ttc	p.L878F	MCTP2_ENST00000451018.3_Missense_Mutation_p.L823F|MCTP2_ENST00000449432.3_3'UTR	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	878					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GCGCAGCGCTCTCTAGGGCAC	0.517000													12	29					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158502225	158502225	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:158502225C>T	ENST00000355585.4	+	19	2727	c.2652C>T	c.(2650-2652)ttC>ttT	p.F884F	SYNJ2_ENST00000367122.2_Silent_p.F884F|SYNJ2_ENST00000367112.1_5'UTR|SYNJ2_ENST00000367121.3_Silent_p.F884F	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	884							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TGTCCTCCTTCCAGGGCCCCC	0.532000													37	57					0	0	1	0	0
SLC10A4	201780	broad.mit.edu	37	4	48490895	48490895	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:48490895C>T	ENST00000273861.4	+	3	1472	c.1253C>T	c.(1252-1254)tCc>tTc	p.S418F		NM_152679.3	NP_689892.1	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	418						integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	6						GCAGACACTTCCTATGGCACA	0.363000													27	31					0	0	1	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686266	108686266	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:108686266C>T	ENST00000397688.2	-	3	837	c.468G>A	c.(466-468)atG>atA	p.M156I	CMKLR1_ENST00000552995.1_Missense_Mutation_p.M156I|CMKLR1_ENST00000550402.1_Missense_Mutation_p.M158I|CMKLR1_ENST00000412676.1_Missense_Mutation_p.M158I|CMKLR1_ENST00000312143.7_Missense_Mutation_p.M158I	NM_004072.2	NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	158					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						CCATGCAGGCCATGTAAGCCA	0.567000													24	72					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34640796	34640796	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:34640796C>T	ENST00000537011.1	+	3	1109	c.727C>T	c.(727-729)Cgt>Tgt	p.R243C	NUTM1_ENST00000438749.3_Missense_Mutation_p.R233C|NUTM1_ENST00000333756.4_Missense_Mutation_p.R215C					NUT midline carcinoma, family member 1																		TGAGAACTTCCGTCAGTGGCA	0.542000													24	71					0	0	1	0	0
ZNF502	91392	broad.mit.edu	37	3	44762800	44762800	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:44762800T>G	ENST00000296091.4	+	4	747	c.491T>G	c.(490-492)tTt>tGt	p.F164C	ZNF502_ENST00000449836.1_Missense_Mutation_p.F164C|ZNF502_ENST00000436624.2_Missense_Mutation_p.F164C	NM_001134440.1|NM_033210.4	NP_001127912.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		GGAAAAACCTTTACTCAGAGC	0.388000													14	131					0	0	1	0	0
TBX1	6899	broad.mit.edu	37	22	19753283	19753283	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:19753283C>T	ENST00000332710.4	+	7	972	c.843C>T	c.(841-843)atC>atT	p.I281I	TBX1_ENST00000329705.7_Silent_p.I281I|TBX1_ENST00000359500.3_Silent_p.I281I	NM_080647.1	NP_542378.1	O43435	TBX1_HUMAN	T-box 1	281					embryonic viscerocranium morphogenesis|heart development|parathyroid gland development|pharyngeal system development|regulation of transcription from RNA polymerase II promoter|soft palate development|thymus development	nucleus	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|lung(3)|ovary(2)	8	Colorectal(54;0.0993)	all_lung(157;3.05e-06)				CCCTGCAGATCACGCAGCTCA	0.647000													23	21					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19483591	19483591	+	Silent	SNP	G	G	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:19483591G>T	ENST00000507958.1	-	14	2691	c.1701C>A	c.(1699-1701)ccC>ccA	p.P567P	CDH18_ENST00000502796.1_Intron|CDH18_ENST00000382275.1_Silent_p.P567P|CDH18_ENST00000506372.1_Intron|CDH18_ENST00000274170.4_Silent_p.P567P			Q13634	CAD18_HUMAN	cadherin 18, type 2	567	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGATCATAATGGGCAGATAAT	0.488000													9	40					2.74318e-10	2.79306e-10	1	1	0
RNASET2	8635	broad.mit.edu	37	6	167343184	167343184	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:167343184G>A	ENST00000366855.6	-	10	1224	c.549C>T	c.(547-549)tcC>tcT	p.S183S	RNASET2_ENST00000508775.1_Silent_p.S221S|RNASET2_ENST00000476238.2_Silent_p.S221S|RP11-514O12.4_ENST00000507747.1_Intron			O00584	RNT2_HUMAN	ribonuclease T2	221					RNA catabolic process	extracellular region	ribonuclease T2 activity|RNA binding			large_intestine(4)|lung(4)	8		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;1.53e-19)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00665)		CCTGCTTGGGGGACGGCTGCT	0.562000													110	151					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66430760	66430760	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:66430760G>A	ENST00000383703.3	-	20	3743	c.3140C>T	c.(3139-3141)cCc>cTc	p.P1047L	LRIG1_ENST00000496559.2_5'UTR|SLC25A26_ENST00000536651.1_3'UTR|LRIG1_ENST00000273261.3_Missense_Mutation_p.P1070L			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	1070						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CGTGGACTCGGGACTGGCGTC	0.552000													17	116					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219875560	219875560	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:219875560C>T	ENST00000341552.5	-	25	4199	c.4116G>A	c.(4114-4116)tgG>tgA	p.W1372*	AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000453220.1_Nonsense_Mutation_p.W1372*|CCDC108_ENST00000441968.1_Nonsense_Mutation_p.W1372*	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1372						integral to membrane	structural molecule activity	p.W1372C(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGAGAAGATCCACAAGACCC	0.567000													12	16					0	0	1	0	0
ARF5	381	broad.mit.edu	37	7	127229594	127229594	+	Silent	SNP	G	G	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:127229594G>T	ENST00000000233.5	+	3	358	c.204G>T	c.(202-204)gtG>gtT	p.V68V	GCC1_ENST00000497650.1_Intron|ARF5_ENST00000467281.1_3'UTR	NM_001662.3	NP_001653.1	P84085	ARF5_HUMAN	ADP-ribosylation factor 5	68					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			cervix(2)|kidney(1)|lung(10)|ovary(1)	14						TCTGGGACGTGGGAGGCCAGG	0.468000													46	79					4.06502e-11	4.15054e-11	1	1	0
PTGS2	5743	broad.mit.edu	37	1	186647512	186647512	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:186647512G>A	ENST00000367468.5	-	4	474	c.338C>T	c.(337-339)cCa>cTa	p.P113L	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	113					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GTAAGTTGGTGGACTGTCAAT	0.358000													29	23					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849972	73849972	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:73849972C>T	ENST00000523207.1	+	3	2970	c.2382C>T	c.(2380-2382)ttC>ttT	p.F794F		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	794					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AGAAACTGTTCCCTTTCTCTT	0.557000													16	81					0	0	1	0	0
ALPL	249	broad.mit.edu	37	1	21887684	21887684	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:21887684C>T	ENST00000374840.3	+	4	526	c.276C>T	c.(274-276)ttC>ttT	p.F92F	ALPL_ENST00000374832.1_Silent_p.F92F|ALPL_ENST00000425315.2_Silent_p.F92F|ALPL_ENST00000540617.1_Silent_p.F37F|ALPL_ENST00000539907.1_Intron|ALPL_ENST00000468526.1_3'UTR	NM_000478.4	NP_000469.3	P05186	PPBT_HUMAN	alkaline phosphatase, liver/bone/kidney	92					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	26		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	TGGACAAGTTCCCCTTCGTGG	0.597000													5	13					0	0	1	0	0
TANGO6	79613	broad.mit.edu	37	16	69056765	69056765	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:69056765C>T	ENST00000261778.1	+	16	2889	c.2877C>T	c.(2875-2877)atC>atT	p.I959I		NM_024562.1	NP_078838.1			transport and golgi organization 6 homolog (Drosophila)																		AACCTTTGATCCATACCTTCC	0.468000													4	6					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55569009	55569009	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:55569009C>T	ENST00000395445.1	-	36	5195	c.4801G>A	c.(4801-4803)Gaa>Aaa	p.E1601K	PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000395446.1_Missense_Mutation_p.E797K|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000395440.1_Missense_Mutation_p.E535K|PCDH15_ENST00000395442.1_Missense_Mutation_p.E466K	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGGAGGATTCCTCCTCTGAT	0.453000										HNSCC(58;0.16)			13	10					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068007	9068007	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9068007C>T	ENST00000397910.4	-	3	19642	c.19439G>A	c.(19438-19440)gGa>gAa	p.G6480E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6482	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGTGAAAATCCATGAGTCAT	0.493000													43	68					0	0	1	0	0
SEPT4	5414	broad.mit.edu	37	17	56598703	56598703	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:56598703G>A	ENST00000457347.2	-	10	1215	c.1071C>T	c.(1069-1071)atC>atT	p.I357I	SEPT4_ENST00000317268.3_Silent_p.I342I|SEPT4_ENST00000579371.1_Silent_p.I243I|SEPT4_ENST00000426861.1_3'UTR|SEPT4_ENST00000580844.1_Silent_p.I243I|RP11-112H10.4_ENST00000580589.1_RNA|SEPT4_ENST00000412945.3_Silent_p.I334I|SEPT4_ENST00000393086.1_Silent_p.I323I|SEPT4_ENST00000317256.6_Silent_p.I323I|SEPT4_ENST00000583114.1_Silent_p.I195I	NM_001256782.1	NP_001243711.1	O43236	SEPT4_HUMAN	septin 4	342					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	18	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCAAATGGGATGCTTTCCT	0.532000											OREG0024614	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	59					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	101847169	101847169	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:101847169C>T	ENST00000369138.1	+	1	506	c.16C>T	c.(16-18)Ccg>Tcg	p.P6S	GRIK2_ENST00000413795.1_Missense_Mutation_p.P6S|GRIK2_ENST00000421544.1_Missense_Mutation_p.P6S|GRIK2_ENST00000369137.3_Missense_Mutation_p.P6S|GRIK2_ENST00000318991.6_Missense_Mutation_p.P6S|GRIK2_ENST00000358361.3_Missense_Mutation_p.P6S	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	6					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GATTATTTTCCCGATTCTAAG	0.488000													32	40					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53741668	53741668	+	Silent	SNP	A	A	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:53741668A>C	ENST00000333952.4	-	5	477	c.312T>G	c.(310-312)ccT>ccG	p.P104P	ZNF677_ENST00000598513.1_Silent_p.P104P			Q86XU0	ZN677_HUMAN	zinc finger protein 677	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		TGTCAAACTTAGGCATATTTT	0.343000													24	47					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118511787	118511787	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:118511787G>A	ENST00000359236.5	-	5	1212	c.936C>T	c.(934-936)tcC>tcT	p.S312S		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	312	Ig-like C2-type 4.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						CAGAGAGAAGGGAGGGACCCC	0.502000													14	44					0	0	1	0	0
C2CD2L	9854	broad.mit.edu	37	11	118981581	118981581	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:118981581C>T	ENST00000336702.3	+	4	954	c.595C>T	c.(595-597)Cct>Tct	p.P199S		NM_014807.3	NP_055622.3	O14523	C2C2L_HUMAN	C2CD2-like	199						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)	13						GGAGGAAATCCCTGGTGAGGG	0.552000													70	87					0	0	1	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86916059	86916059	+	Missense_Mutation	SNP	C	C	T	rs149783359		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:86916059C>T	ENST00000395184.1	+	9	1718	c.1252C>T	c.(1252-1254)Ctc>Ttc	p.L418F	ARHGAP24_ENST00000395183.2_Missense_Mutation_p.L323F|ARHGAP24_ENST00000264343.4_Missense_Mutation_p.L325F	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	418					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		AAGCCCCCCTCTCATGGTCAA	0.473000													77	146					0	0	1	0	0
CALD1	800	broad.mit.edu	37	7	134618203	134618203	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:134618203T>C	ENST00000361675.2	+	5	912	c.683T>C	c.(682-684)tTa>tCa	p.L228S	CALD1_ENST00000361388.2_Intron|CALD1_ENST00000361901.2_Intron|CALD1_ENST00000422748.1_Intron|CALD1_ENST00000424922.1_Intron|CALD1_ENST00000417172.1_Intron|CALD1_ENST00000543443.1_Intron|CALD1_ENST00000393118.2_Intron|CALD1_ENST00000495522.1_Intron			Q05682	CALD1_HUMAN	caldesmon 1	228					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						GTAATGTCATTAAAAAATGGG	0.448000													22	37					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538458	55538458	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:55538458G>A	ENST00000220676.1	+	4	2164	c.2016G>A	c.(2014-2016)aaG>aaA	p.K672K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	672	Poly-Lys.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCAGCAAAAAGAAGAAAAAAT	0.333000													26	30					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41545984	41545984	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:41545984C>T	ENST00000263253.7	+	14	3818	c.2599C>T	c.(2599-2601)Cct>Tct	p.P867S		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	867					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TCCTACACCTCCTGCCATGCC	0.592000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				17	88					0	0	1	0	0
METTL16	79066	broad.mit.edu	37	17	2381162	2381162	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:2381162G>A	ENST00000263092.5	-	3	273	c.146C>T	c.(145-147)cCc>cTc	p.P49L	METTL16_ENST00000538844.1_5'UTR|METTL16_ENST00000571669.1_5'UTR	NM_024086.3	NP_076991.3	Q86W50	MET16_HUMAN	methyltransferase like 16	49							methyltransferase activity			kidney(2)|large_intestine(9)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	19						GACTGCTTCGGGGTCTTTAAA	0.403000													14	82					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88968026	88968026	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:88968026C>T	ENST00000268679.4	-	2	586	c.190G>A	c.(190-192)Gac>Aac	p.D64N	CBFA2T3_ENST00000360302.2_Missense_Mutation_p.D3N|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.D3N|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.D64N|CBFA2T3_ENST00000448839.1_Intron	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	64	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).|Pro-rich.|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GCTGGGGAGTCCGGCATCGCT	0.682000			T	RUNX1	AML								18	49					0	0	1	0	0
DYX1C1	161582	broad.mit.edu	37	15	55722941	55722941	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:55722941G>A	ENST00000321149.3	-	10	1557	c.1190C>T	c.(1189-1191)cCa>cTa	p.P397L	DYX1C1_ENST00000448430.2_Intron|DYX1C1_ENST00000348518.3_Missense_Mutation_p.H362Y|DYX1C1-CCPG1_ENST00000565113.1_RNA|DYX1C1_ENST00000380679.1_Intron|DYX1C1_ENST00000457155.2_Missense_Mutation_p.H362Y	NM_130810.3	NP_570722.2	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1	397					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		TTTGTTGGATGGATCAATCTT	0.299000													16	40					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16251661	16251661	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:16251661G>A	ENST00000205557.7	-	27	3770	c.3741C>T	c.(3739-3741)ccC>ccT	p.P1247P		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	1247					response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GCAGCCTCCAGGGAGCCTGGA	0.597000													19	30					0	0	1	0	0
TUBA1A	7846	broad.mit.edu	37	12	49579070	49579070	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:49579070G>A	ENST00000301071.7	-	4	1423	c.1079C>T	c.(1078-1080)cCc>cTc	p.P360L	TUBA1A_ENST00000295766.5_Missense_Mutation_p.P360L|TUBA1A_ENST00000550767.1_Missense_Mutation_p.P325L	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	360					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						CACCACAGTGGGAGGCTGGTA	0.577000													26	24					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131418768	131418768	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:131418768C>T	ENST00000512055.1	-	8	2543	c.417G>A	c.(415-417)ggG>ggA	p.G139G	CPNE4_ENST00000502818.1_Silent_p.G157G|CPNE4_ENST00000512332.1_Silent_p.G157G|CPNE4_ENST00000511604.1_Silent_p.G139G|CPNE4_ENST00000429747.1_Silent_p.G139G			Q96A23	CPNE4_HUMAN	copine IV	139										central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						TGGAAGATTTCCCTGCTGTGT	0.502000													17	18					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750298	142750298	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:142750298C>T	ENST00000418316.1	+	1	882	c.861C>T	c.(859-861)atC>atT	p.I287I		NM_001001667.1	NP_001001667.1	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V, member 1	287					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	20	Melanoma(164;0.059)					ATCCCTTTATCCTTACCTTCT	0.522000													34	47					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153665857	153665857	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:153665857C>T	ENST00000368680.3	+	22	3625	c.3153C>T	c.(3151-3153)ctC>ctT	p.L1051L		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	1051					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	CCTACTGGCTCCTTGGGGAGA	0.612000													106	70					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47538834	47538834	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:47538834C>T	ENST00000273859.3	+	9	1544	c.1275C>T	c.(1273-1275)atC>atT	p.I425I	ATP10D_ENST00000504445.1_Silent_p.I410I	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	425					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						CCCTGAACATCGCCGAGGATC	0.408000													5	16					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	79639029	79639029	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:79639029C>T	ENST00000464233.1	-	2	146	c.33G>A	c.(31-33)atG>atA	p.M11I		NM_002941.3	NP_002932.1	Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	11					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GGAGTGATATCATGACCAAAA	0.408000													63	58					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220309595	220309595	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:220309595C>T	ENST00000312358.7	+	3	659	c.527C>T	c.(526-528)tCc>tTc	p.S176F	SPEG_ENST00000396698.1_Missense_Mutation_p.S72F|SPEG_ENST00000396695.2_5'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	176					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCCCGACCTCCGTGACAGGC	0.672000													30	114					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458237	248458237	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:248458237G>A	ENST00000317996.1	-	1	643	c.644C>T	c.(643-645)tCc>tTc	p.S215F		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GAGACCATAGGAGGACAGGAT	0.537000													81	55					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25674775	25674775	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:25674775C>T	ENST00000382051.3	+	10	1165	c.1115C>T	c.(1114-1116)tCc>tTc	p.S372F	SLC34A2_ENST00000504570.1_Missense_Mutation_p.S371F|SLC34A2_ENST00000503434.1_Missense_Mutation_p.S371F	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	372					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				CTCATACTCTCCCTGCTGGTC	0.517000			T	ROS1	NSCLC								10	85					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115614259	115614259	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:115614259C>T	ENST00000265440.7	-	3	412	c.232G>A	c.(232-234)Gaa>Aaa	p.E78K	TFEC_ENST00000484212.1_Missense_Mutation_p.E168K|TFEC_ENST00000393485.1_Intron|TFEC_ENST00000320239.7_Intron	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	78	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			TCTGCTCCTTCCTCTTTAAAA	0.328000													19	32					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94156489	94156489	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:94156489C>T	ENST00000553484.1	+	47	7449	c.7295C>T	c.(7294-7296)tCc>tTc	p.S2432F	UNC79_ENST00000393151.2_Missense_Mutation_p.S2410F|UNC79_ENST00000256339.4_Missense_Mutation_p.S2233F|UNC79_ENST00000555664.1_Missense_Mutation_p.S2371F			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2410						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GAGTGTGTCTCCCATATCCGA	0.453000													27	48					0	0	1	0	0
STAT5B	6777	broad.mit.edu	37	17	40370239	40370239	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:40370239G>A	ENST00000293328.3	-	9	1267	c.1099C>T	c.(1099-1101)Ccc>Tcc	p.P367S		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	367					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	TTCACCTGGGGGGGGTTCATG	0.577000													14	45					0	0	1	0	0
CDKL5	6792	broad.mit.edu	37	X	18616669	18616669	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:18616669C>T	ENST00000379989.3	+	12	1198	c.913C>T	c.(913-915)Cgt>Tgt	p.R305C	CDKL5_ENST00000379996.3_Missense_Mutation_p.R305C	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	305					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					ACTTCTGGATCGTTCTCCTTC	0.388000													15	50					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78831722	78831722	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:78831722C>T	ENST00000537330.1	+	12	2259	c.976C>T	c.(976-978)Ccc>Tcc	p.P326S	RPTOR_ENST00000575542.1_Intron|RPTOR_ENST00000306801.3_Intron|RPTOR_ENST00000544334.2_Intron			Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	0					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						CGCCCTCCTCCCCAGAGTGAT	0.647000													14	15					0	0	1	0	0
TRIM36	55521	broad.mit.edu	37	5	114469560	114469560	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:114469560G>A	ENST00000513154.1	-	8	1821	c.1495C>T	c.(1495-1497)Cca>Tca	p.P499S	TRIM36_ENST00000282369.3_Missense_Mutation_p.P511S|TRIM36_ENST00000514154.1_Missense_Mutation_p.P356S			Q9NQ86	TRI36_HUMAN	tripartite motif containing 36	511	Fibronectin type-III.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			breast(3)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	37		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		ACCATACCTGGAGCTGGAGGA	0.393000													4	29					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17669558	17669558	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:17669558C>T	ENST00000262077.2	-	7	979	c.980G>A	c.(979-981)aGa>aAa	p.R327K	NUP153_ENST00000537253.1_Missense_Mutation_p.R327K	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	327					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding	p.R327I(1)		NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GGATGGAATTCTTTTTGCATC	0.279000													37	57					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136570323	136570323	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:136570323C>T	ENST00000264162.2	-	7	1921	c.1911G>A	c.(1909-1911)gtG>gtA	p.V637V		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	637	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGTCTCCATCCACAAAGACGG	0.582000													31	100					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22324726	22324726	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:22324726G>A	ENST00000398793.2	-	6	871	c.437C>T	c.(436-438)aCc>aTc	p.T146I	TOP3B_ENST00000413067.2_Intron|TOP3B_ENST00000357179.5_Missense_Mutation_p.T146I	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	146	Toprim.				DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		CCGGAACACGGTCTTCTCGCC	0.607000													29	30					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49444089	49444089	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:49444089G>A	ENST00000301067.7	-	11	3281	c.3282C>T	c.(3280-3282)ctC>ctT	p.L1094L		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TTGGGGAAGGGAGAGGACTGG	0.612000													9	16					0	0	1	0	0
CSN3	1448	broad.mit.edu	37	4	71114747	71114747	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:71114747G>A	ENST00000304954.3	+	4	206	c.120G>A	c.(118-120)caG>caA	p.Q40Q		NM_005212.2	NP_005203.2	P07498	CASK_HUMAN	casein kappa	40						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						CATTCTATCAGAAAACAGCTC	0.318000													20	88					0	0	1	0	0
ZNF812	729648	broad.mit.edu	37	19	9801109	9801109	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9801109C>T	ENST00000457674.2	-	5	1588	c.1070G>A	c.(1069-1071)gGa>gAa	p.G357E	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGGCTTCTCTCCTGTGTGAAT	0.393000													23	28					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149558091	149558091	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:149558091C>T	ENST00000223210.4	+	7	2087	c.1842C>T	c.(1840-1842)atC>atT	p.I614I		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	614					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						AGAGGGAGATCCTGGAGGACG	0.587000													16	29					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123909484	123909484	+	Silent	SNP	C	C	T	rs138227924		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:123909484C>T	ENST00000330487.5	-	1	233	c.225G>A	c.(223-225)acG>acA	p.T75T		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TTTTGGGCACCGTGACAGTGG	0.537000													30	108					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149544995	149544995	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:149544995C>T	ENST00000223210.4	+	4	658	c.413C>T	c.(412-414)tCc>tTc	p.S138F		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						AAGCCCCGGTCCATCCAGAAG	0.557000													11	15					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62757842	62757842	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:62757842C>T	ENST00000281156.4	-	3	555	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	93	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		CCTGTTTCTTCCTGTAGCCTC	0.373000													14	60					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43770451	43770451	+	Silent	SNP	T	T	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:43770451T>G	ENST00000389420.3	-	33	5000	c.5001A>C	c.(4999-5001)tcA>tcC	p.S1667S		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1667	TSP type-1 15.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CACAAGTCACTGAGCACTGTG	0.368000													36	47					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3214914	3214914	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:3214914T>C	ENST00000380059.3	-	5	568	c.467A>G	c.(466-468)gAc>gGc	p.D156G	SLC4A11_ENST00000380056.3_Missense_Mutation_p.D129G|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Missense_Mutation_p.D113G	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	129					cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						GCCATCTAGGTCGCGGTGCGC	0.602000													5	163					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40947896	40947896	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:40947896G>A	ENST00000246914.5	+	16	3297	c.3276G>A	c.(3274-3276)aaG>aaA	p.K1092K		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1092					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		ATGATGGGAAGGAACCCCAAG	0.627000													16	49					0	0	1	0	0
ANO10	55129	broad.mit.edu	37	3	43618376	43618376	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:43618376G>A	ENST00000292246.3	-	6	1140	c.970C>T	c.(970-972)Ctc>Ttc	p.L324F	ANO10_ENST00000414522.2_Missense_Mutation_p.L324F|ANO10_ENST00000396091.3_Missense_Mutation_p.L258F|ANO10_ENST00000451430.2_Missense_Mutation_p.L213F|ANO10_ENST00000350459.4_Intron	NM_018075.3	NP_060545.3	Q9NW15	ANO10_HUMAN	anoctamin 10	324					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						TAGAGGCAGAGGCACACGAAT	0.507000													7	64					0	0	1	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409612	17409612	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:17409612G>A	ENST00000339994.4	-	1	594	c.27C>T	c.(25-27)ccC>ccT	p.P9P	KCNJ11_ENST00000528731.1_Intron	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	0						integral to membrane	ATP-activated inward rectifier potassium channel activity			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		CGTATTCCTCGGGGATGATGC	0.672000													4	91					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22962274	22962274	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:22962274A>G	ENST00000313077.7	+	19	2227	c.2102A>G	c.(2101-2103)cAa>cGa	p.Q701R	CYFIP1_ENST00000560848.1_Missense_Mutation_p.Q701R|CYFIP1_ENST00000435939.2_Missense_Mutation_p.Q270R	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	701					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TGTTTTGACCAATTTGTTTAC	0.343000													29	40					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164506934	164506934	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:164506934G>A	ENST00000503008.1	-	6	1366	c.390C>T	c.(388-390)ttC>ttT	p.F130F	MARCH1_ENST00000514618.1_Silent_p.F386F|MARCH1_ENST00000274056.7_Silent_p.F130F|MARCH1_ENST00000339875.5_Silent_p.F113F	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	130					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.F113F(1)|p.F130F(1)		endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCTCCATTATGAAGTCATACT	0.493000													6	66					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070509	9070509	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9070509G>A	ENST00000397910.4	-	3	17140	c.16937C>T	c.(16936-16938)tCc>tTc	p.S5646F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5648	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATGTGGAGGAAACAGGAGA	0.517000													7	27					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116599764	116599764	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:116599764C>G	ENST00000395715.3	-	5	2741	c.2164G>C	c.(2164-2166)Gag>Cag	p.E722Q	TRPS1_ENST00000519674.1_Missense_Mutation_p.E709Q|TRPS1_ENST00000220888.5_Missense_Mutation_p.E709Q|TRPS1_ENST00000520276.1_Missense_Mutation_p.E713Q|TRPS1_ENST00000519076.1_Missense_Mutation_p.E463Q	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	709	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTGAAGTGCTCCAGTAGTGAC	0.493000									Langer-Giedion syndrome				125	73					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78225183	78225183	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:78225183C>T	ENST00000361193.3	+	17	1992	c.1712C>T	c.(1711-1713)tCt>tTt	p.S571F	SLC26A11_ENST00000546047.2_Missense_Mutation_p.S571F|SLC26A11_ENST00000411502.3_Missense_Mutation_p.S571F|SLC26A11_ENST00000572725.1_Missense_Mutation_p.S571F	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	571	STAS.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CAGTACTTCTCTACCCTGGAA	0.488000													29	68					0	0	1	0	0
ITGB6	3694	broad.mit.edu	37	2	161029125	161029125	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:161029125G>A	ENST00000283249.2	-	6	1113	c.876C>T	c.(874-876)ctC>ctT	p.L292L	ITGB6_ENST00000409967.2_Silent_p.L292L|ITGB6_ENST00000428609.2_Silent_p.L250L|ITGB6_ENST00000485635.1_5'UTR|ITGB6_ENST00000409872.1_Silent_p.L292L			P18564	ITB6_HUMAN	integrin, beta 6	292	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						CCAAGTGACAGAGCCCGTCAT	0.468000													17	162					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158736437	158736437	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:158736437G>A	ENST00000335094.2	-	1	55	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					CCAAGATGATGAATTCTGCTA	0.463000													12	69					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143772241	143772241	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:143772241C>T	ENST00000408898.2	+	1	967	c.929C>T	c.(928-930)tCa>tTa	p.S310L		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					AAGAGAACTTCATGAAAGCCT	0.398000													88	171					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112665	248112665	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:248112665G>A	ENST00000357191.3	+	1	506	c.506G>A	c.(505-507)cGa>cAa	p.R169Q	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CCTTATTGCCGATCCAGGGCC	0.478000													56	48					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40947897	40947897	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:40947897G>A	ENST00000246914.5	+	16	3298	c.3277G>A	c.(3277-3279)Gaa>Aaa	p.E1093K		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1093					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TGATGGGAAGGAACCCCAAGT	0.622000													16	50					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31500279	31500279	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:31500279C>T	ENST00000330498.3	+	11	1378	c.1359C>T	c.(1357-1359)ttC>ttT	p.F453F		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	453					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						GGCAGCTCTTCGATTACATCC	0.662000													16	74					0	0	1	0	0
IMPA2	3613	broad.mit.edu	37	18	11999176	11999176	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:11999176C>T	ENST00000269159.3	+	2	462	c.220C>T	c.(220-222)Cct>Tct	p.P74S	IMPA2_ENST00000588927.1_5'UTR|IMPA2_ENST00000588752.1_3'UTR|IMPA2_ENST00000589238.1_5'UTR	NM_014214.2	NP_055029.1	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	74					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|skin(2)|stomach(2)|urinary_tract(1)	12					Lithium(DB01356)	AGAGAGGTTTCCTTCACACAG	0.493000													56	32					0	0	1	0	0
SLA	6503	broad.mit.edu	37	8	134050865	134050865	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:134050865G>A	ENST00000338087.5	-	9	1554	c.735C>T	c.(733-735)acC>acT	p.T245T	SLA_ENST00000395352.3_Silent_p.T262T|TG_ENST00000542445.1_Intron|SLA_ENST00000517648.1_Silent_p.T218T|SLA_ENST00000427060.2_Silent_p.T285T|SLA_ENST00000524345.1_Silent_p.T137T|TG_ENST00000519543.1_Intron|TG_ENST00000220616.4_Intron|TG_ENST00000377869.1_Intron	NM_001045556.2	NP_001039021.1	Q13239	SLAP1_HUMAN	Src-like-adaptor	245	SLA C-terminal.					endosome	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(6)|prostate(1)|skin(1)	17	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			GATCAAAGGAGGTGTTGTCCT	0.498000													15	162					0	0	1	0	0
GALNT13	114805	broad.mit.edu	37	2	155295197	155295197	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:155295197C>T	ENST00000392825.3	+	12	2056	c.1489C>T	c.(1489-1491)Cac>Tac	p.H497Y	AC009227.2_ENST00000434635.1_RNA|GALNT13_ENST00000409237.1_Missense_Mutation_p.H497Y	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	497	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						GTTAAAATGCCACCATATGAG	0.333000													25	51					0	0	1	0	0
TEAD1	7003	broad.mit.edu	37	11	12923645	12923645	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:12923645C>T	ENST00000361905.4	+	10	1478	c.813C>T	c.(811-813)ttC>ttT	p.F271F	TEAD1_ENST00000334310.6_Intron|TEAD1_ENST00000527636.1_Silent_p.F286F|TEAD1_ENST00000526600.1_Silent_p.F190F|TEAD1_ENST00000361985.2_Silent_p.F286F|TEAD1_ENST00000527575.1_Intron	NM_021961.5	NP_068780.2	P28347	TEAD1_HUMAN	TEA domain family member 1 (SV40 transcriptional enhancer factor)	286	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)	17				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		ATGCCTTCTTCCTCGTAAAAT	0.428000													68	66					0	0	1	0	0
CAMTA2	23125	broad.mit.edu	37	17	4883268	4883268	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:4883268C>T	ENST00000361571.5	-	8	1757	c.1346G>A	c.(1345-1347)gGg>gAg	p.G449E	CAMTA2_ENST00000348066.3_Missense_Mutation_p.G450E|CAMTA2_ENST00000381311.5_Missense_Mutation_p.G452E|CAMTA2_ENST00000414043.3_Missense_Mutation_p.G473E|CAMTA2_ENST00000358183.4_Missense_Mutation_p.G450E|CAMTA2_ENST00000572543.1_Missense_Mutation_p.G455E	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	450					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GAGCTCCTCCCCACTGTCATC	0.642000													58	90					0	0	1	0	0
GBAP1	2630	broad.mit.edu	37	1	155188247	155188247	+	RNA	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:155188247C>T	ENST00000486869.1	-	0	119					NR_002188.2																						TGATGCTTACCCTACCCGAAG	0.552000													49	227					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13724823	13724823	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:13724823G>A	ENST00000279593.3	-	10	2295	c.2086C>T	c.(2086-2088)Cgc>Tgc	p.R696C		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	696					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.R696C(1)		NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAGTTATTGCGAATATTTCTC	0.483000													22	43					0	0	1	0	0
BAI2	576	broad.mit.edu	37	1	32221722	32221722	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:32221722G>A	ENST00000373658.3	-	4	1057	c.716C>T	c.(715-717)cCa>cTa	p.P239L	BAI2_ENST00000257070.4_Missense_Mutation_p.P239L|BAI2_ENST00000398556.3_Missense_Mutation_p.P242L|BAI2_ENST00000373655.2_Missense_Mutation_p.P239L|BAI2_ENST00000527361.1_Missense_Mutation_p.P239L|BAI2_ENST00000398538.1_Missense_Mutation_p.P227L|BAI2_ENST00000398542.1_Missense_Mutation_p.P227L|BAI2_ENST00000398547.1_Missense_Mutation_p.P227L	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	239					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		AGGAGGGCCTGGAGATGTGGT	0.706000													24	36					0	0	1	0	0
WNT7A	7476	broad.mit.edu	37	3	13860507	13860507	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:13860507G>A	ENST00000285018.4	-	4	1288	c.984C>T	c.(982-984)ttC>ttT	p.F328F		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	328					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						AGCACCAGTGGAACTTACAGT	0.617000													4	58					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94716613	94716613	+	Splice_Site	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:94716613A>G	ENST00000304338.3	+	15	1870	c.1717_splice	c.e15+1	p.E572_splice		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	572						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AATTAATTGAACGTAAGTAAT	0.318000													8	17					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90425381	90425381	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:90425381G>A	ENST00000369393.3	-	45	6966	c.6851C>T	c.(6850-6852)cCc>cTc	p.P2284L	MDN1_ENST00000428876.1_Missense_Mutation_p.P2284L			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2284					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCTGAAATTGGGATTTGGTGT	0.418000													18	103					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15792603	15792603	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:15792603C>T	ENST00000359621.4	+	6	628	c.603C>T	c.(601-603)atC>atT	p.I201I	CELA2B_ENST00000494280.1_3'UTR	NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	201	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						CCAGTATGATCTGTGCTGGGG	0.572000													67	108					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14478758	14478758	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:14478758G>A	ENST00000581457.1	-	0	1150					NR_024076.1																						TACTGTAATGGAAGTGAACCT	0.348000													3	19					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66430759	66430759	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:66430759G>A	ENST00000383703.3	-	20	3744	c.3141C>T	c.(3139-3141)ccC>ccT	p.P1047P	LRIG1_ENST00000496559.2_5'UTR|SLC25A26_ENST00000536651.1_3'UTR|LRIG1_ENST00000273261.3_Silent_p.P1070P			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	1070						integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCGTGGACTCGGGACTGGCGT	0.552000													17	116					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35800230	35800230	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:35800230C>T	ENST00000440995.2	+	34	4976	c.4976C>T	c.(4975-4977)tCc>tTc	p.S1659F	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.S1664F|SPEF2_ENST00000303129.4_Missense_Mutation_p.S461F			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1664					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTCAAAGCTTCCATTCCAAGT	0.458000													53	48					0	0	1	0	0
DDX46	9879	broad.mit.edu	37	5	134154612	134154612	+	Silent	SNP	C	C	T	rs138063978	byFrequency	TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:134154612C>T	ENST00000452510.2	+	21	3053	c.2895C>T	c.(2893-2895)gcC>gcT	p.A965A	DDX46_ENST00000354283.4_Silent_p.A964A	NM_014829.2	NP_055644.2	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	964					mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACTCTGAAGCCGCAATTACAA	0.413000													14	19					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48271757	48271757	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:48271757G>A	ENST00000225964.5	-	23	1685	c.1567C>T	c.(1567-1569)Cct>Tct	p.P523S		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	523	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GCTTCACCAGGAGATCCTTTG	0.622000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						61	96					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10971013	10971013	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:10971013G>A	ENST00000254488.2	+	10	1425	c.1359G>A	c.(1357-1359)gtG>gtA	p.V453V		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	453					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TGGGCCTCGTGATGTTAACAG	0.582000													18	147					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321216	56321216	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:56321216G>A	ENST00000443188.1	-	5	1470	c.760C>T	c.(760-762)Ccc>Tcc	p.P254S	NLRP11_ENST00000360133.3_Missense_Mutation_p.P254S|NLRP11_ENST00000589824.2_Missense_Mutation_p.P254S|NLRP11_ENST00000592953.1_Missense_Mutation_p.P155S|NLRP11_ENST00000589093.1_Missense_Mutation_p.P254S	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	254	NACHT.						ATP binding	p.P254S(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ACTGGAATGGGAACTTTCTGG	0.448000													30	34					0	0	1	0	0
TRAK2	66008	broad.mit.edu	37	2	202245710	202245710	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:202245710G>A	ENST00000332624.3	-	16	2729	c.2301C>T	c.(2299-2301)ctC>ctT	p.L767L		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	767				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						GGGATTTAGGGAGAGGCTGGA	0.517000													91	126					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100551975	100551975	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:100551975C>T	ENST00000319509.7	+	1	726	c.726C>T	c.(724-726)atC>atT	p.I242I						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						CCACTATTATCATGTCCTCTT	0.413000													178	1023					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714720	92714720	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:92714720G>A	ENST00000257068.2	+	2	337	c.331G>A	c.(331-333)Gag>Aag	p.E111K		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	111					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CCTGGGGGAGGAGCACTGCAA	0.582000													73	61					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31023388	31023388	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:31023388C>T	ENST00000375687.4	+	13	3297	c.2873C>T	c.(2872-2874)tCa>tTa	p.S958L	ASXL1_ENST00000306058.5_Missense_Mutation_p.S953L	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	958					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						AGCCTTACTTCACTCTGGACT	0.527000			"""F, N, Mis"""		"""MDS, CMML"""								69	47					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164856	139164856	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:139164856C>T	ENST00000395297.1	-	13	2032	c.1862G>A	c.(1861-1863)gGa>gAa	p.G621E		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	621										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTGATCTATTCCCTTTCCTAG	0.473000										HNSCC(54;0.14)			16	122					0	0	1	0	0
ACSM3	6296	broad.mit.edu	37	16	20803445	20803445	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:20803445C>G	ENST00000289416.5	+	11	1923	c.1448C>G	c.(1447-1449)tCc>tGc	p.S483C	ACSM3_ENST00000567387.1_3'UTR|ACSM3_ENST00000450120.2_Missense_Mutation_p.S475C|ERI2_ENST00000300005.3_Intron	NM_005622.3	NP_005613.2	Q53FZ2	ACSM3_HUMAN	acyl-CoA synthetase medium-chain family member 3	483					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	21						GTCATATTATCCTCTGGGTAA	0.403000													53	102					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140183220	140183220	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140183220C>T	ENST00000532566.2	+	1	2438	c.2438C>T	c.(2437-2439)tCa>tTa	p.S813L	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_031497.1	NP_113685.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTTGTTTTTCATTCCTCAAT	0.338000													8	25					0	0	1	0	0
IL18R1	8809	broad.mit.edu	37	2	102998082	102998082	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:102998082C>T	ENST00000409599.1	+	7	984	c.628C>T	c.(628-630)Cgc>Tgc	p.R210C	IL18R1_ENST00000233957.1_Missense_Mutation_p.R210C			Q13478	IL18R_HUMAN	interleukin 18 receptor 1	210	Ig-like C2-type 2.		R -> H (in dbSNP:rs11465635).		innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			breast(1)|endometrium(3)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						ACTTCTAGATCGCAGTAATAT	0.328000													5	19					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88391839	88391839	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:88391839C>T	ENST00000298699.2	-	4	442	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	C12orf50_ENST00000550553.1_Missense_Mutation_p.E88K	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	88										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						TCCTCTTCTTCCTCAAAATTA	0.348000													7	15					0	0	1	0	0
IGHV3OR16-9	28307	broad.mit.edu	37	16	33647492	33647492	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:33647492G>A	ENST00000558425.1	-	2	107	c.108C>T	c.(106-108)tcC>tcT	p.S36S																								ACAGTCTCAGGGACCCCCCAG	0.572000													32	175					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3319465	3319465	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:3319465G>A	ENST00000378398.3	+	7	872	c.790G>A	c.(790-792)Ggc>Agc	p.G264S	PRDM16_ENST00000378391.2_Missense_Mutation_p.G263S|PRDM16_ENST00000442529.2_Missense_Mutation_p.G263S|PRDM16_ENST00000441472.2_Missense_Mutation_p.G263S|PRDM16_ENST00000514189.1_Missense_Mutation_p.G264S|PRDM16_ENST00000270722.5_Missense_Mutation_p.G263S|PRDM16_ENST00000511072.1_Missense_Mutation_p.G264S|PRDM16_ENST00000512462.1_3'UTR			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	263					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCTCTACGAGGGCCTGGCTGA	0.632000			T	EVI1	"""MDS, AML"""								33	45					0	0	1	0	0
IGHD	3495	broad.mit.edu	37	14	106311889	106311889	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:106311889G>A	ENST00000390556.2	-	0	121																											CCATGTACCAGGTGACAGTCA	0.562000													27	30					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21120418	21120418	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:21120418G>A	ENST00000377122.4	-	15	1940	c.1544C>T	c.(1543-1545)tCc>tTc	p.S515F	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	515					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGCCATCTCGGATGCTTTCTT	0.428000													23	18					0	0	1	0	0
NEU4	129807	broad.mit.edu	37	2	242755721	242755721	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:242755721G>A	ENST00000391969.2	+	3	751	c.40G>A	c.(40-42)Gag>Aag	p.E14K	NEU4_ENST00000407683.1_Missense_Mutation_p.E14K|NEU4_ENST00000404257.1_Missense_Mutation_p.E26K|NEU4_ENST00000405370.1_Missense_Mutation_p.E14K|NEU4_ENST00000325935.6_Missense_Mutation_p.E27K	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	14						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		AGTGCTCTTCGAGCGGGAGAG	0.692000													31	73					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31562485	31562485	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:31562485G>A	ENST00000379416.3	-	34	3692	c.3644C>T	c.(3643-3645)tCc>tTc	p.S1215F		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	1215					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CCCCTCGGGGGAATAGTGTAG	0.602000													36	39					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132556461	132556461	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:132556461C>T	ENST00000265342.7	-	12	1686	c.1437G>A	c.(1435-1437)acG>acA	p.T479T	CTB-49A3.2_ENST00000509051.1_RNA|CTB-49A3.2_ENST00000502776.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	479						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAATCTTTTCCGTGGGTTTGA	0.478000													32	44					0	0	1	0	0
TMEM237	65062	broad.mit.edu	37	2	202492842	202492842	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:202492842G>A	ENST00000409444.2	-	10	1193	c.876C>T	c.(874-876)atC>atT	p.I292I	TMEM237_ENST00000409883.2_Silent_p.I300I|TMEM237_ENST00000466839.1_5'UTR	NM_152388.3	NP_689601.2	Q96Q45	TM237_HUMAN	transmembrane protein 237	324						integral to membrane	protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)	7						AAAAATTTCGGATTGCTACTG	0.323000													6	13					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18305764	18305764	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:18305764C>A	ENST00000441493.2	-	23	3608	c.3256G>T	c.(3256-3258)Gag>Tag	p.E1086*		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1086	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		TCTGCTGCCTCCCCTTCTATC	0.572000													8	73					1.12685e-05	1.13464e-05	1	1	0
LAMA2	3908	broad.mit.edu	37	6	129470195	129470195	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:129470195G>A	ENST00000421865.2	+	7	1030	c.981G>A	c.(979-981)caG>caA	p.Q327Q		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	327	Laminin EGF-like 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GATTCCATCAGAAACCCTGGA	0.403000													23	41					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90385232	90385232	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:90385232G>A	ENST00000369393.3	-	78	12827	c.12712C>T	c.(12712-12714)Cga>Tga	p.R4238*	RP1-122O8.7_ENST00000438877.1_RNA|MDN1_ENST00000428876.1_Nonsense_Mutation_p.R4238*			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	4238					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CGCCGCTGTCGGACGAGCATC	0.532000													27	37					0	0	1	0	0
ADAM33	80332	broad.mit.edu	37	20	3652869	3652869	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:3652869G>A	ENST00000356518.2	-	14	1750	c.1509C>T	c.(1507-1509)gaC>gaT	p.D503D	ADAM33_ENST00000466620.1_5'UTR|ADAM33_ENST00000350009.2_Silent_p.D503D|ADAM33_ENST00000379861.4_Silent_p.D503D	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	503	Cys-rich.|Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						AGGGTGAGCCGTCCAGTAGGT	0.662000													4	142					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24879218	24879218	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:24879218C>T	ENST00000382554.3	+	4	2536	c.2218C>T	c.(2218-2220)Cag>Tag	p.Q740*		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	740					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GCACCAGTTTCAGATGGAGGG	0.632000													4	25					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172480255	172480255	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:172480255C>T	ENST00000417960.1	+	9	1189	c.712C>T	c.(712-714)Cca>Tca	p.P238S	ECT2_ENST00000427830.1_Missense_Mutation_p.P239S|ECT2_ENST00000392692.3_Missense_Mutation_p.P270S|ECT2_ENST00000441497.2_Missense_Mutation_p.P239S|ECT2_ENST00000232458.5_Missense_Mutation_p.P239S|ECT2_ENST00000540509.1_Missense_Mutation_p.P270S	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	239	BRCT 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			TAAAGTTCCTCCATTTCAAGA	0.303000													20	22					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174110	51174110	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:51174110G>A	ENST00000440970.1	-	2	2163	c.1732C>T	c.(1732-1734)Cct>Tct	p.P578S	SALL1_ENST00000251020.4_Missense_Mutation_p.P675S|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	675					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P675S(1)		NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCCCCAAAAGGAAACTTGGCC	0.582000													16	104					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7242713	7242713	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:7242713G>A	ENST00000542285.1	-	3	509	c.360C>T	c.(358-360)tcC>tcT	p.S120S				P00736	C1R_HUMAN	complement component 1, r subcomponent	121	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCTCCTCGTTGGAGAAGTCTG	0.547000													9	17					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103234148	103234148	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:103234148C>T	ENST00000428762.1	-	27	4052	c.3893G>A	c.(3892-3894)gGa>gAa	p.G1298E	RELN_ENST00000343529.5_Missense_Mutation_p.G1298E|RELN_ENST00000424685.2_Missense_Mutation_p.G1298E	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1298					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TAGCACATATCCAGGTTTCAG	0.393000													35	77					0	0	1	0	0
LRRN2	10446	broad.mit.edu	37	1	204587926	204587926	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:204587926C>T	ENST00000367175.1	-	1	3407	c.1195G>A	c.(1195-1197)Gag>Aag	p.E399K	LRRN2_ENST00000367177.3_Missense_Mutation_p.E399K|LRRN2_ENST00000367176.3_Missense_Mutation_p.E399K			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	399	LRRCT.				cell adhesion	integral to membrane	receptor activity	p.E399K(1)		central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TCCGGAGGCTCCGCACACAGG	0.662000													124	67					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89400535	89400535	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:89400535G>A	ENST00000439576.2	+	12	5093	c.4719G>A	c.(4717-4719)agG>agA	p.R1573R	ACAN_ENST00000559004.1_Silent_p.R1573R|ACAN_ENST00000352105.7_Silent_p.R1573R|ACAN_ENST00000561243.1_Silent_p.R1573R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1573					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTTCTGGAAGGGAGGGTCTAG	0.542000													26	41					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382192	152382192	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:152382192C>T	ENST00000271835.3	-	3	1428	c.1366G>A	c.(1366-1368)Gac>Aac	p.D456N	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	456					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGCCCTGGTCCAGCCTGAGG	0.557000													90	43					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114824085	114824085	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:114824085G>A	ENST00000315366.7	-	2	2011	c.1145C>T	c.(1144-1146)cCc>cTc	p.P382L	ARSJ_ENST00000541197.1_Missense_Mutation_p.P382L	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	382						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		AATGAGAGTGGGGTACCAGTC	0.498000													21	140					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4281538	4281538	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:4281538G>A	ENST00000404826.2	+	43	6383	c.6244G>A	c.(6244-6246)Ggg>Agg	p.G2082R	SDK1_ENST00000466611.1_3'UTR|SDK1_ENST00000389531.3_Missense_Mutation_p.G2062R	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2082					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAAGAAGAACGGGACCAGGTA	0.642000													20	42					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				37	63					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50186633	50186633	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:50186633G>A	ENST00000335999.6	-	11	3678	c.3477C>T	c.(3475-3477)ccC>ccT	p.P1159P		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	1155	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						GCCGAGCTGGGGGTACCCCAG	0.672000													5	26					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53785796	53785796	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:53785796C>T	ENST00000288139.3	+	29	3715	c.3597C>T	c.(3595-3597)gcC>gcT	p.A1199A	CACNA1D_ENST00000540742.1_Silent_p.A86A|CACNA1D_ENST00000350061.5_Silent_p.A1179A|CACNA1D_ENST00000422281.2_Silent_p.A1179A	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1179					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTGAATACGCCTTGAAAGCAC	0.512000													42	148					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43766249	43766249	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:43766249G>A	ENST00000244293.7	-	3	538	c.472C>T	c.(472-474)Ccc>Tcc	p.P158S	PSG9_ENST00000443718.3_Intron|PSG9_ENST00000593948.1_Missense_Mutation_p.P158S|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000291752.5_Intron|PSG9_ENST00000270077.3_Missense_Mutation_p.P158S			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	158	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				GCCTCCCTGGGGTTTAAGTTG	0.532000													73	236					0	0	1	0	0
ZNF628	89887	broad.mit.edu	37	19	55992909	55992909	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:55992909C>T	ENST00000598519.1	+	3	902	c.349C>T	c.(349-351)Ctg>Ttg	p.L117L	ZNF628_ENST00000391718.2_Silent_p.L113L	NM_033113.2	NP_149104.3	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	113						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		GCACACCGGCCTGCGGGCCTT	0.672000													5	36					0	0	1	0	0
CHGB	1114	broad.mit.edu	37	20	5903151	5903151	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:5903151G>A	ENST00000378961.4	+	4	565	c.361G>A	c.(361-363)Gag>Aag	p.E121K		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	121						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						GGCAGACACAGAGAAATGGGC	0.627000													13	10					0	0	1	0	0
PAPD4	167153	broad.mit.edu	37	5	78940988	78940988	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:78940988C>T	ENST00000453514.1	+	8	1487	c.794C>T	c.(793-795)cCa>cTa	p.P265L	PAPD4_ENST00000423041.2_Missense_Mutation_p.P261L|PAPD4_ENST00000296783.3_Missense_Mutation_p.P265L|PAPD4_ENST00000504233.1_Missense_Mutation_p.P265L|PAPD4_ENST00000428308.2_Missense_Mutation_p.P265L	NM_001114394.1	NP_001107866.1	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	265					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			biliary_tract(1)|breast(2)|endometrium(4)|kidney(3)|large_intestine(9)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		GCAAAAGTGCCAATTGTGAAG	0.343000													5	22					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10894130	10894130	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:10894130G>A	ENST00000283141.6	+	3	405	c.109G>A	c.(109-111)Gat>Aat	p.D37N	RP11-637O19.3_ENST00000480294.1_3'UTR|SYCP2L_ENST00000543878.1_5'UTR	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	37						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TGCATTCCATGATAAAGGATT	0.303000													10	24					0	0	1	0	0
TRBV19	28568	broad.mit.edu	37	7	142326486	142326486	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:142326486G>A	ENST00000390393.3	+	0	124																											CTGCACATTAGGCCAGGAGAA	0.512000													3	19					0	0	1	0	0
TMEM70	54968	broad.mit.edu	37	8	74888620	74888620	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:74888620C>T	ENST00000312184.5	+	1	177	c.104C>T	c.(103-105)tCt>tTt	p.S35F	TMEM70_ENST00000523794.1_3'UTR|TMEM70_ENST00000517439.1_Missense_Mutation_p.S35F	NM_001040613.2|NM_017866.5	NP_001035703.1|NP_060336.3	Q9BUB7	TMM70_HUMAN	transmembrane protein 70	35					mitochondrial proton-transporting ATP synthase complex assembly	integral to mitochondrial membrane|mitochondrial inner membrane				breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	8	Breast(64;0.0311)		Epithelial(68;0.0186)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0564)			CCCCGGGCCTCTGTCTCCCGG	0.731000													32	10					0	0	1	0	0
HTR3D	200909	broad.mit.edu	37	3	183756374	183756374	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:183756374G>A	ENST00000382489.3	+	7	1097	c.1097G>A	c.(1096-1098)gGa>gAa	p.G366E	HTR3D_ENST00000334128.2_Missense_Mutation_p.G191E|HTR3D_ENST00000453435.1_Missense_Mutation_p.G145E|HTR3D_ENST00000428798.2_Missense_Mutation_p.G316E	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	366						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCCCAGAAGGGAAATAAGGGC	0.657000													12	32					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49168221	49168221	+	Silent	SNP	G	G	A	rs115957272	by1000genomes	TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:49168221G>A	ENST00000307885.4	-	13	2941	c.2247C>T	c.(2245-2247)tcC>tcT	p.S749S	ADCY6_ENST00000550422.1_Silent_p.S749S|ADCY6_ENST00000552090.1_5'UTR|ADCY6_ENST00000357869.3_Silent_p.S749S	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	749					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CAAGCAGGACGGAAAAGATGC	0.557000													27	51					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193031915	193031915	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:193031915C>T	ENST00000342358.4	-	19	2343	c.2226G>A	c.(2224-2226)gtG>gtA	p.V742V	ATP13A5-AS1_ENST00000414634.1_RNA	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	742					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CAACAATGATCACTTGGCTGC	0.468000													68	49					0	0	1	0	0
TWISTNB	221830	broad.mit.edu	37	7	19739776	19739776	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:19739776T>A	ENST00000222567.5	-	3	594	c.524A>T	c.(523-525)gAt>gTt	p.D175V		NM_001002926.1	NP_001002926.1	Q3B726	RPA43_HUMAN	TWIST neighbor	175						microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	20						TTCTAGTTCATCACCCATGTT	0.408000													28	164					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077349	9077349	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9077349G>A	ENST00000397910.4	-	3	10300	c.10097C>T	c.(10096-10098)tCc>tTc	p.S3366F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3367	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAGGATATTGGAAGATGTGCT	0.468000													58	165					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21015708	21015708	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:21015708G>A	ENST00000381545.3	+	8	866	c.647G>A	c.(646-648)gGa>gAa	p.G216E	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G216E|LST3_ENST00000540229.1_Missense_Mutation_p.G216E|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.G216E|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	216					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					AATGCAATAGGAATGATTGGT	0.318000													16	52					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701903	56701903	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:56701903C>T	ENST00000586855.2	-	5	1094	c.781G>A	c.(781-783)Gcc>Acc	p.A261T	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.A261T			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	261					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TCCACAGAGGCTCTTTTCTGG	0.493000													29	87					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141812796	141812796	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:141812796C>T	ENST00000389484.3	-	10	2412	c.1441G>A	c.(1441-1443)Gga>Aga	p.G481R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	481					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCTGGCATTCCATATGGATCG	0.443000										TSP Lung(27;0.18)			22	34					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110838762	110838762	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr13:110838762G>A	ENST00000375820.4	-	26	1988	c.1867C>T	c.(1867-1869)Cct>Tct	p.P623S		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	623	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GGGCCTCCAGGAAAGCCTGCT	0.607000													120	74					0	0	1	0	0
PAEP	5047	broad.mit.edu	37	9	138457324	138457324	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:138457324C>A	ENST00000479141.1	+	5	534	c.490C>A	c.(490-492)Cac>Aac	p.H164N	PAEP_ENST00000371766.2_Missense_Mutation_p.H164N|PAEP_ENST00000277508.5_Missense_Mutation_p.H164N	NM_002571.2	NP_002562.2	P09466	PAEP_HUMAN	progestagen-associated endometrial protein	164					multicellular organismal development	extracellular region	binding|transporter activity			cervix(1)|endometrium(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	6				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		CCTGCCCAGGCACCTATGGTA	0.592000													14	51					7.93312e-07	8.01014e-07	1	1	0
ASTN2	23245	broad.mit.edu	37	9	119858427	119858427	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:119858427C>T	ENST00000313400.4	-	5	1272	c.1172G>A	c.(1171-1173)gGa>gAa	p.G391E	ASTN2_ENST00000361209.2_Missense_Mutation_p.G340E|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.G391E			O75129	ASTN2_HUMAN	astrotactin 2	391						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						AAAGCTGATTCCTCCTGTGAG	0.557000													28	18					0	0	1	0	0
KLHL22	84861	broad.mit.edu	37	22	20796595	20796595	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr22:20796595C>T	ENST00000328879.4	-	7	1826	c.1670G>A	c.(1669-1671)gGc>gAc	p.G557D	KLHL22_ENST00000440659.2_Missense_Mutation_p.G414D	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	557					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TGTGCGGCTGCCGCGGTTGTG	0.612000													26	81					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40368658	40368658	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:40368658G>A	ENST00000221347.6	-	28	12697	c.12690C>T	c.(12688-12690)ttC>ttT	p.F4230F		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4230	VWFD 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGCCATTAGGGAAGACCTGGT	0.642000													31	152					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													4	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179552868	179552868	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:179552868C>T	ENST00000589042.1	-	127	32505	c.32281G>A	c.(32281-32283)Gag>Aag	p.E10761K	TTN_ENST00000591111.1_Missense_Mutation_p.E10444K|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E9517K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10444	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCTTCCTCCTCCTCTCTT	0.388000													27	82					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13850769	13850769	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:13850769G>A	ENST00000265104.4	-	31	5210	c.5106C>T	c.(5104-5106)tcC>tcT	p.S1702S		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1702	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ACCCAGTAAGGGATTTCTGGC	0.463000									Kartagener syndrome				18	62					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756631	248756631	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:248756631C>T	ENST00000330500.2	-	1	469	c.439G>A	c.(439-441)Ggc>Agc	p.G147S		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AACCAGCAGCCTGATGCCAGG	0.547000													113	75					0	0	1	0	0
BCMO1	53630	broad.mit.edu	37	16	81295790	81295790	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:81295790C>T	ENST00000258168.2	+	4	834	c.373C>T	c.(373-375)Ctg>Ttg	p.L125L	BCMO1_ENST00000564552.1_Silent_p.L125L|BCMO1_ENST00000425577.2_Silent_p.L56L	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	125					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						CGACAACTGCCTGATCAACAT	0.498000													52	118					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46244858	46244858	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:46244858C>T	ENST00000334344.6	+	15	3124	c.2952C>T	c.(2950-2952)gtC>gtT	p.V984V	ARID2_ENST00000444670.1_Silent_p.V594V|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Silent_p.V835V	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	984	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ATAACCAAGTCCCTACTGCCA	0.488000			"""N, S, F"""		hepatocellular carcinoma								48	87					0	0	1	0	0
DLL4	54567	broad.mit.edu	37	15	41229062	41229062	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:41229062C>T	ENST00000249749.5	+	9	2153	c.1877C>T	c.(1876-1878)aCc>aTc	p.T626I		NM_019074.3	NP_061947.1	Q9NR61	DLL4_HUMAN	delta-like 4 (Drosophila)	626					blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(3)|large_intestine(1)	4		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGGCGGGGGACCATGCCAGGA	0.597000													21	29					0	0	1	0	0
CHN1	1123	broad.mit.edu	37	2	175742627	175742627	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:175742627G>A	ENST00000409900.3	-	6	803	c.490C>T	c.(490-492)Ctg>Ttg	p.L164L	CHN1_ENST00000409156.3_Silent_p.L164L|CHN1_ENST00000488080.1_Intron	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	164					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			GTCTCTTTCAGGACTGGCATA	0.413000			T	TAF15	extraskeletal myxoid chondrosarcoma								26	58					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89943434	89943434	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:89943434A>G	ENST00000405460.2	+	17	3238	c.3142A>G	c.(3142-3144)Aga>Gga	p.R1048G		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1048					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGCTACTGCAAGAGAGAGAGA	0.418000													42	50					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109610100	109610100	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:109610100C>T	ENST00000338432.7	+	6	1175	c.1056C>T	c.(1054-1056)ggC>ggT	p.G352G	ACACB_ENST00000377848.3_Silent_p.G352G|ACACB_ENST00000377854.5_Silent_p.G352G			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	352	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CTGGCTGGGGCCATGCTTCAG	0.512000													77	211					0	0	1	0	0
CNN3	1266	broad.mit.edu	37	1	95363557	95363557	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:95363557G>A	ENST00000370206.4	-	7	1114	c.731C>T	c.(730-732)tCc>tTc	p.S244F	CNN3_ENST00000545882.1_Missense_Mutation_p.S203F|CNN3_ENST00000538964.1_Missense_Mutation_p.S244F|CNN3_ENST00000394202.4_Missense_Mutation_p.S198F|CNN3_ENST00000487539.1_5'UTR	NM_001839.3	NP_001830.1	Q15417	CNN3_HUMAN	calponin 3, acidic	244					actomyosin structure organization|smooth muscle contraction		actin binding|calmodulin binding|tropomyosin binding|troponin C binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|stomach(1)|urinary_tract(2)	18		all_lung(203;0.00206)|Lung NSC(277;0.00948)		all cancers(265;0.0325)|Epithelial(280;0.0861)		CATCTGTAGGGAAATTGTCGA	0.463000													56	90					0	0	1	0	0
CEP57L1	285753	broad.mit.edu	37	6	109480270	109480270	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:109480270T>A	ENST00000407272.1	+	10	1364	c.787T>A	c.(787-789)Tca>Aca	p.S263T	CEP57L1_ENST00000520883.1_Missense_Mutation_p.S187T|CEP57L1_ENST00000517392.1_Missense_Mutation_p.S263T|CEP57L1_ENST00000521522.1_Missense_Mutation_p.S234T|CEP57L1_ENST00000336977.4_Missense_Mutation_p.S187T|CEP57L1_ENST00000368968.2_Missense_Mutation_p.S263T|CEP57L1_ENST00000368970.2_Missense_Mutation_p.S263T|CEP57L1_ENST00000359793.3_Missense_Mutation_p.S263T|CEP57L1_ENST00000523787.1_Missense_Mutation_p.S266T	NM_001083535.1	NP_001077004.1	Q8IYX8	CE57L_HUMAN	centrosomal protein 57kDa-like 1	263						microtubule|microtubule organizing center				endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)	11						GCAAATTTGTTCAAAGTTTGG	0.328000													29	35					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642539	57642539	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:57642539C>T	ENST00000254181.4	+	4	2950	c.2496C>T	c.(2494-2496)atC>atT	p.I832I	USP29_ENST00000598197.1_Silent_p.I832I	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	832					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCAGCCATATCGGGAGCTCCC	0.473000													9	43					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92139226	92139226	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:92139226G>A	ENST00000256343.3	-	13	1269	c.1113C>T	c.(1111-1113)taC>taT	p.Y371Y		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	371					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TATAGAAGAGGTAAACTCCAG	0.348000													50	50					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19634765	19634765	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:19634765G>A	ENST00000328041.6	+	7	869	c.672G>A	c.(670-672)gtG>gtA	p.V224V		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	224						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CGCTGTCTGTGATCGCGCTCA	0.517000													25	64					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22940632	22940632	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:22940632C>T	ENST00000397104.3	-	5	1805	c.1806G>A	c.(1804-1806)agG>agA	p.R602R	ZNF99_ENST00000596209.1_Silent_p.R693R					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTTATGTTTCCTAAGGGCTG	0.373000													22	53					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109545722	109545722	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:109545722G>A	ENST00000409271.1	-	5	731	c.288C>T	c.(286-288)ttC>ttT	p.F96F	EDAR_ENST00000258443.2_Silent_p.F96F|EDAR_ENST00000376651.1_Silent_p.F96F			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	96					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						TGGCCCGGAAGAAGCCCTCAC	0.612000													15	49					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63852146	63852146	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:63852146C>T	ENST00000279873.7	+	10	3334	c.2924C>T	c.(2923-2925)tCa>tTa	p.S975L	ARID5B_ENST00000309334.5_Missense_Mutation_p.S732L	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	975					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CTTTCAAGATCAGGAAAACCT	0.522000													47	41					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47045637	47045637	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:47045637C>T	ENST00000450053.3	+	37	6131	c.5952C>T	c.(5950-5952)cgC>cgT	p.R1984R	NBEAL2_ENST00000383740.2_Silent_p.R263R|NBEAL2_ENST00000292309.5_Silent_p.R1800R	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1984							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		TCAACCTGCGCCGTTCAGCAC	0.587000													207	158					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82544950	82544950	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:82544950G>A	ENST00000423517.2	-	7	12689	c.12352C>T	c.(12352-12354)Cct>Tct	p.P4118S	PCLO_ENST00000437081.1_Missense_Mutation_p.P838S|PCLO_ENST00000333891.8_Missense_Mutation_p.P4118S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4049					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AACTCGTAAGGATCCTCCATT	0.443000													28	40					0	0	1	0	0
CPSF6	11052	broad.mit.edu	37	12	69656215	69656215	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:69656215C>T	ENST00000435070.2	+	9	1642	c.1532C>T	c.(1531-1533)tCc>tTc	p.S511F	CPSF6_ENST00000456847.3_Missense_Mutation_p.S438F|CPSF6_ENST00000266679.8_Missense_Mutation_p.S548F|CPSF6_ENST00000551516.1_Intron	NM_007007.2	NP_008938.2	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6, 68kDa	511	Arg-rich.|Sufficient for nuclear targeting.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(7)|lung(8)	16	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			CGTCATAAATCCCGTAGTAGA	0.473000													11	65					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129290539	129290539	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:129290539G>A	ENST00000393239.1	-	16	3404	c.3226C>T	c.(3226-3228)Ccc>Tcc	p.P1076S	PLXND1_ENST00000324093.4_Missense_Mutation_p.P1076S			Q9Y4D7	PLXD1_HUMAN	plexin D1	1076	IPT/TIG 3.				axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CTGCGGCGGGGACTGATGGCC	0.667000													75	58					0	0	1	0	0
SPINT1	6692	broad.mit.edu	37	15	41145988	41145988	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:41145988C>T	ENST00000344051.4	+	5	1056	c.822C>T	c.(820-822)atC>atT	p.I274I	SPINT1_ENST00000562057.1_Silent_p.I274I|SPINT1_ENST00000431806.1_Silent_p.I274I			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	274	BPTI/Kunitz inhibitor 1.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		CGGAGCAGATCTGCAAGAGTT	0.562000													38	119					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67298300	67298300	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:67298300G>T	ENST00000299798.11	+	13	1953	c.1888G>T	c.(1888-1890)Gag>Tag	p.E630*		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	630					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		GGATGCGCAGGAGCGGCAGGA	0.577000													8	30					9.70103e-10	9.86361e-10	1	1	0
TTC21B	79809	broad.mit.edu	37	2	166786250	166786250	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:166786250G>A	ENST00000243344.7	-	10	1232	c.1095C>T	c.(1093-1095)atC>atT	p.I365I		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	365						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						ACTGACATTGGATAAATCCTA	0.368000													19	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179407408	179407408	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:179407408G>A	ENST00000589042.1	-	348	97397	c.97173C>T	c.(97171-97173)acC>acT	p.T32391T	TTN_ENST00000591111.1_Silent_p.T30750T|TTN_ENST00000342175.6_Silent_p.T23518T|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Silent_p.T23451T|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000460472.2_Silent_p.T23326T|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000342992.6_Silent_p.T29823T|TTN-AS1_ENST00000586831.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30750	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACTTTAATGGTTTCTGAAG	0.338000													83	141					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10973727	10973727	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr21:10973727C>T	ENST00000298232.7	-	4	374	c.7G>A	c.(7-9)Gaa>Aaa	p.E3K	TPTE_ENST00000342420.5_Missense_Mutation_p.E3K|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Missense_Mutation_p.E3K	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	3					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTCACCTTTCATTCATACGT	0.373000													12	67					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53453062	53453062	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:53453062G>A	ENST00000314250.6	+	18	1927	c.1637G>A	c.(1636-1638)gGa>gAa	p.G546E	TENC1_ENST00000549700.1_Missense_Mutation_p.G546E|TENC1_ENST00000552570.1_Missense_Mutation_p.G546E|TENC1_ENST00000546602.1_Missense_Mutation_p.G546E|TENC1_ENST00000451358.1_Missense_Mutation_p.G546E|TENC1_ENST00000314276.3_Missense_Mutation_p.G556E|TENC1_ENST00000379902.3_Missense_Mutation_p.G422E	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	546					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CGCCTCCTAGGAGGCTGCGGA	0.701000													5	11					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130410937	130410937	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:130410937C>T	ENST00000370904.1	-	20	3467	c.2557G>A	c.(2557-2559)Gac>Aac	p.D853N	IGSF1_ENST00000370910.1_Missense_Mutation_p.D853N|IGSF1_ENST00000361420.3_Missense_Mutation_p.D862N|IGSF1_ENST00000467244.1_5'UTR|IGSF1_ENST00000370903.3_Missense_Mutation_p.D867N			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	862	Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TCCACAGGGTCGCTGGGCTCA	0.557000													119	89					0	0	1	0	0
CRTC3	64784	broad.mit.edu	37	15	91182039	91182039	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:91182039C>T	ENST00000420329.2	+	13	1687	c.1540C>T	c.(1540-1542)Cct>Tct	p.P514S	RP11-387D10.2_ENST00000559531.1_RNA|CRTC3_ENST00000268184.6_Missense_Mutation_p.P514S	NM_001042574.2|NM_022769.4	NP_001036039.1|NP_073606.3	Q6UUV7	CRTC3_HUMAN	CREB regulated transcription coactivator 3	514					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	breast(1)|endometrium(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			CCCTGCCTTTCCTCAACAGGT	0.493000			T	MAML2	salivary gland mucoepidermoid								10	34					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95757660	95757660	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:95757660C>T	ENST00000311106.3	-	5	781	c.543_splice	c.e5-1	p.D182_splice	CTD-2337A12.1_ENST00000502645.2_RNA|PCSK1_ENST00000508626.1_Splice_Site_p.D135_splice	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	182	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity	p.D182N(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCCTCTGGATCCTAAAGAGAC	0.358000													25	33					0	0	1	0	0
DNA2	1763	broad.mit.edu	37	10	70229752	70229752	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:70229752G>A	ENST00000399180.2	-	2	500	c.501C>T	c.(499-501)atC>atT	p.I167I	DNA2_ENST00000358410.3_Silent_p.I81I|DNA2_ENST00000399179.2_Silent_p.I81I			P51530	DNA2L_HUMAN	DNA replication helicase/nuclease 2	81					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						CATTCCTAAGGATGCATAGTT	0.393000													4	7					0	0	1	0	0
ZNF728	388523	broad.mit.edu	37	19	23159466	23159466	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:23159466C>T	ENST00000594710.1	-	4	818	c.673G>A	c.(673-675)Gag>Aag	p.E225K		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		CAGGGTTTCTCTCCAGTATGA	0.358000													12	33					0	0	1	0	0
ZNF451	26036	broad.mit.edu	37	6	57012419	57012419	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:57012419C>T	ENST00000370706.4	+	10	1780	c.1536C>T	c.(1534-1536)gtC>gtT	p.V512V	RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|ZNF451_ENST00000357489.3_Silent_p.V512V|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592500.1_RNA|ZNF451_ENST00000491832.2_Silent_p.V512V|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	512					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			ATTCAGGGGTCATTCGTTTAC	0.408000													194	156					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35131548	35131548	+	RNA	SNP	G	G	A	rs144021252	by1000genomes	TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:35131548G>A	ENST00000436258.1	-	0	1821																											TGGCACCTGCGAAGACAGCAT	0.388000													3	47					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34881062	34881062	+	Silent	SNP	T	T	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:34881062T>C	ENST00000431794.3	-	6	933	c.411A>G	c.(409-411)ggA>ggG	p.G137G	MYO19_ENST00000544606.1_Intron|MYO19_ENST00000268852.9_Silent_p.G137G|MYO19_ENST00000586007.1_Silent_p.G137G	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	137	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TTCCTACCTTTCCAGCACCAC	0.522000													11	166					0	0	1	0	0
SPRY4	81848	broad.mit.edu	37	5	141694699	141694699	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:141694699G>A	ENST00000344120.4	-	3	230	c.44C>T	c.(43-45)tCc>tTc	p.S15F	SPRY4_ENST00000503582.1_5'UTR|SPRY4_ENST00000434127.2_5'UTR	NM_030964.3	NP_112226.2	Q9C004	SPY4_HUMAN	sprouty homolog 4 (Drosophila)	0					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(1)	18		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACTGTACGGAGAAACAGGC	0.612000									Testicular Cancer, Familial Clustering of				11	22					0	0	1	0	0
PCOLCE	5118	broad.mit.edu	37	7	100204225	100204225	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:100204225G>A	ENST00000223061.5	+	6	1192	c.912G>A	c.(910-912)gaG>gaA	p.E304E		NM_002593.3	NP_002584.2	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	304		Cleavage.			multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					AACCTCCGGAGAAAACAGAGG	0.597000													20	45					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141812795	141812795	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:141812795C>T	ENST00000389484.3	-	10	2413	c.1442G>A	c.(1441-1443)gGa>gAa	p.G481E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	481					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCTGGCATTCCATATGGATC	0.448000										TSP Lung(27;0.18)			21	34					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25174578	25174578	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:25174578G>A	ENST00000276440.7	+	14	1418	c.1374G>A	c.(1372-1374)ggG>ggA	p.G458G		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	458	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TTGACAAAGGGAAGAAGAAGA	0.507000													31	110					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16259588	16259588	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:16259588C>T	ENST00000375759.3	+	11	7057	c.6853C>T	c.(6853-6855)Cca>Tca	p.P2285S		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2285	Interaction with MSX2 (By similarity).|RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TTCTAGGCCTCCAGTCAATGC	0.547000													63	94					0	0	1	0	0
TMTC3	160418	broad.mit.edu	37	12	88566395	88566395	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:88566395C>T	ENST00000266712.6	+	8	1292	c.1072C>T	c.(1072-1074)Cca>Tca	p.P358S		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	358						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						AATGGCATTACCATTTATTCC	0.299000													29	47					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140214184	140214184	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140214184G>A	ENST00000525929.1	+	1	216	c.216G>A	c.(214-216)ggG>ggA	p.G72G	PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000378125.3_Silent_p.G72G|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATTCCGTGGGGATCTTCTGG	0.617000													112	147					0	0	1	0	0
ZIC4	84107	broad.mit.edu	37	3	147114146	147114146	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:147114146C>T	ENST00000383075.3	-	3	693	c.181G>A	c.(181-183)Gga>Aga	p.G61R	ZIC4_ENST00000484399.1_Missense_Mutation_p.G61R|ZIC4_ENST00000425731.3_Missense_Mutation_p.G99R|ZIC4_ENST00000473123.1_Missense_Mutation_p.G61R|ZIC4_ENST00000491672.1_Intron|ZIC4_ENST00000525172.2_Missense_Mutation_p.G111R	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	61						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						CGCAGGAGTCCATTCAAAGGA	0.736000													9	38					0	0	1	0	0
APOO	79135	broad.mit.edu	37	X	23876823	23876823	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:23876823G>A	ENST00000379226.4	-	6	647	c.416C>T	c.(415-417)cCg>cTg	p.P139L	APOO_ENST00000379220.3_Missense_Mutation_p.P120L	NM_024122.4	NP_077027.1	Q9BUR5	APOO_HUMAN	apolipoprotein O	139					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|prostate(1)	9						GAAACCAGGCGGATACACTAG	0.403000													30	21					0	0	1	0	0
TTLL7	79739	broad.mit.edu	37	1	84412889	84412889	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:84412889G>A	ENST00000260505.8	-	6	801	c.424C>T	c.(424-426)Caa>Taa	p.Q142*	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	142	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		ACATAATTTTGGAATTGAGTA	0.358000													4	34					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105393510	105393510	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:105393510G>A	ENST00000351513.2	-	9	1608	c.1476C>T	c.(1474-1476)ccC>ccT	p.P492P	DPYS_ENST00000521601.1_5'UTR	NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	492					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTCCCTTATAGGGTGCACGCT	0.488000													68	39					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189859478	189859478	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:189859478G>A	ENST00000304636.3	+	20	1546	c.1376G>A	c.(1375-1377)gGa>gAa	p.G459E	COL3A1_ENST00000317840.5_Missense_Mutation_p.G459E	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	459	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGTGTTCCAGGAGCTAAAGGC	0.433000													43	54					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160278903	160278903	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:160278903G>T	ENST00000241704.7	-	13	1436	c.1207C>A	c.(1207-1209)Cag>Aag	p.Q403K	COPA_ENST00000368069.3_Missense_Mutation_p.Q403K	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	403					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCAGGATTCTGGGAGTCAGCA	0.433000													13	134					4.7546e-09	4.81412e-09	1	1	0
TPP2	7174	broad.mit.edu	37	13	103317235	103317235	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr13:103317235A>G	ENST00000376052.3	+	27	3347	c.3331A>G	c.(3331-3333)Atg>Gtg	p.M1111V	TPP2_ENST00000466153.1_3'UTR|TPP2_ENST00000376065.4_Missense_Mutation_p.M1098V			P29144	TPP2_HUMAN	tripeptidyl peptidase II	1098					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTATATTGCAATGAAGACTGA	0.358000													6	28					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28713961	28713961	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:28713961G>A	ENST00000257197.3	-	13	2270	c.2009C>T	c.(2008-2010)cCa>cTa	p.P670L	DSC1_ENST00000257198.5_Missense_Mutation_p.P670L|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	670	Cadherin 5.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ACACTCAGATGGAGTTGAACA	0.363000													56	49					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156135423	156135423	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:156135423C>T	ENST00000329476.3	+	2	821	c.332C>T	c.(331-333)aCc>aTc	p.T111I	NPY2R_ENST00000506608.1_Missense_Mutation_p.T111I	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	111					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				CTTACCTATACCTTAATGGGG	0.488000													8	46					0	0	1	0	0
IGHV3-23	28442	broad.mit.edu	37	14	106725435	106725435	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:106725435G>A	ENST00000390609.2	-	0	195																											CTGCACAGGAGAGTCTCAGGG	0.572000													96	515					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133474253	133474253	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:133474253G>A	ENST00000402696.3	+	5	1034	c.549G>A	c.(547-549)ggG>ggA	p.G183G	TF_ENST00000264998.3_Silent_p.G56G	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	183	Transferrin-like 1.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	GTGCGGATGGGACGGACTTCC	0.572000													45	37					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140985287	140985287	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:140985287G>A	ENST00000544766.1	+	5	1376	c.849G>A	c.(847-849)agG>agA	p.R283R	MAGEC3_ENST00000536088.1_Silent_p.R283R|MAGEC3_ENST00000443323.2_Silent_p.R203R|MAGEC3_ENST00000409007.1_Silent_p.R283R|MAGEC3_ENST00000298296.1_Intron	NM_177456.2	NP_803251.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	0	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					GTGCTGGGAGGGAGCACTTTA	0.512000													34	84					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325020	79325020	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:79325020C>T	ENST00000428286.1	-	8	2293	c.1093G>A	c.(1093-1095)Gaa>Aaa	p.E365K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E724K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	724					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CTACCCAGTTCAGGCTGACCA	0.468000													29	9					0	0	1	0	0
FCAR	2204	broad.mit.edu	37	19	55396759	55396759	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:55396759G>A	ENST00000355524.3	+	3	193	c.183G>A	c.(181-183)atG>atA	p.M61I	FCAR_ENST00000469767.1_Missense_Mutation_p.M61I|FCAR_ENST00000391725.3_Missense_Mutation_p.M61I|FCAR_ENST00000345937.4_Missense_Mutation_p.M61I|FCAR_ENST00000482092.2_3'UTR|FCAR_ENST00000391724.3_Missense_Mutation_p.M49I|FCAR_ENST00000391726.3_Missense_Mutation_p.M49I|FCAR_ENST00000359272.4_Missense_Mutation_p.M49I|FCAR_ENST00000353758.4_Intron|FCAR_ENST00000391723.3_Missense_Mutation_p.M49I	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	61	Ig-like C2-type 1.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity	p.M61I(2)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		CCCAGCTGATGATCATAAAAA	0.468000													22	43					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238048610	238048610	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:238048610G>A	ENST00000366570.4	-	9	1324	c.1166C>T	c.(1165-1167)cCc>cTc	p.P389L	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	389	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCCAATGTAGGGGCAGCTAGA	0.512000													5	51					0	0	1	0	0
FAM196A	642938	broad.mit.edu	37	10	128973907	128973907	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:128973907C>T	ENST00000522781.1	-	4	1308	c.753G>A	c.(751-753)acG>acA	p.T251T	FAM196A_ENST00000424811.2_Silent_p.T251T|DOCK1_ENST00000280333.6_Intron	NM_001039762.2	NP_001034851.1	Q6ZSG2	F196A_HUMAN	family with sequence similarity 196, member A	251										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TGGCAACCTCCGTTTTAAACA	0.657000													14	13					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573519	140573519	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140573519G>A	ENST00000239446.4	+	1	1578	c.1394G>A	c.(1393-1395)aGc>aAc	p.S465N		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		465	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGAACAACAGCCCCGCCCTG	0.632000													94	156					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54797943	54797943	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:54797943C>T	ENST00000293379.4	-	15	1812	c.1551G>A	c.(1549-1551)ggG>ggA	p.G517G	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	517					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CCACAGGGTTCCCCTCTAAGC	0.612000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	93					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9014639	9014639	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9014639C>T	ENST00000397910.4	-	31	38539	c.38336G>A	c.(38335-38337)aGc>aAc	p.S12779N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12781	SEA 5.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CACTCCAGGGCTTTTGGGGTC	0.557000													39	81					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													4	41					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995558	19995558	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:19995558G>A	ENST00000391403.2	-	1	2320	c.2217C>T	c.(2215-2217)ttC>ttT	p.F739F		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	739	Pro-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GGGCTGGGGGGAAAAATGCAG	0.498000													20	13					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120764282	120764282	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:120764282G>A	ENST00000273666.6	+	5	641	c.369_splice	c.e5-1	p.G124_splice	STXBP5L_ENST00000471454.1_Splice_Site_p.G124_splice|STXBP5L_ENST00000472879.1_Splice_Site_p.G124_splice|STXBP5L_ENST00000492541.1_Splice_Site_p.G124_splice|STXBP5L_ENST00000497029.1_Splice_Site_p.G124_splice	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	124					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		TTTGTTCTAGGGTGCCTTGGT	0.358000													12	103					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117114214	117114214	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:117114214C>T	ENST00000310357.3	-	6	1893	c.1872G>A	c.(1870-1872)gtG>gtA	p.V624V	GPRC6A_ENST00000368549.3_Silent_p.V553V|GPRC6A_ENST00000530250.1_Silent_p.V449V	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	624					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CGGATGATTTCACAACAGGTG	0.428000													31	53					0	0	1	0	0
ZNF25	219749	broad.mit.edu	37	10	38241319	38241319	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:38241319G>A	ENST00000302609.7	-	6	1319	c.1107C>T	c.(1105-1107)ccC>ccT	p.P369P	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				TGCATTCATAGGGCTTCTCCC	0.408000													34	20					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23066296	23066296	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:23066296G>A	ENST00000246006.4	-	1	681	c.534C>T	c.(532-534)ttC>ttT	p.F178F		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	178					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					ACTTGCACACGAAGCCCTCAA	0.652000													62	61					0	0	1	0	0
BTBD3	22903	broad.mit.edu	37	20	11903989	11903989	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:11903989C>T	ENST00000405977.1	+	5	1869	c.1244C>T	c.(1243-1245)tCc>tTc	p.S415F	BTBD3_ENST00000378226.2_Missense_Mutation_p.S415F|BTBD3_ENST00000254977.3_Missense_Mutation_p.S354F|BTBD3_ENST00000399006.2_Missense_Mutation_p.S354F			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	415								p.S415C(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						CTGTATGGCTCCAGCTGTGGT	0.517000													12	81					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240387	3240387	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:3240387C>T	ENST00000217939.6	-	5	3493	c.3339G>A	c.(3337-3339)gcG>gcA	p.A1113A		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1113						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTGTGGTTTCCGCAGGCTTCT	0.493000													29	27					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92531653	92531653	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:92531653C>T	ENST00000298047.6	+	9	5491	c.5474C>T	c.(5473-5475)aCg>aTg	p.T1825M	FAT3_ENST00000409404.2_Missense_Mutation_p.T1825M|FAT3_ENST00000525166.1_Missense_Mutation_p.T1675M			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1825	Cadherin 16.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAGTTTTTCACGGTGGACTCC	0.473000										TCGA Ovarian(4;0.039)			15	9					0	0	1	0	0
PACRGL	133015	broad.mit.edu	37	4	20728952	20728952	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:20728952C>T	ENST00000360916.5	+	8	1045	c.654C>T	c.(652-654)tcC>tcT	p.S218S	PACRGL_ENST00000295290.8_Silent_p.S218S|PACRGL_ENST00000507634.1_Silent_p.S218S|PACRGL_ENST00000538990.1_Silent_p.S120S|PACRGL_ENST00000502374.1_3'UTR|PACRGL_ENST00000444671.2_Silent_p.S120S|PACRGL_ENST00000503585.1_Silent_p.S245S|PACRGL_ENST00000513459.1_Silent_p.S165S|PACRGL_ENST00000502938.1_Silent_p.S84S	NM_145048.3	NP_659485.1	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like	245							binding	p.S218S(1)		endometrium(2)|lung(7)|prostate(1)	10						CATACTGCTCCATATGCTGTT	0.368000													8	57					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712283	121712283	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:121712283G>A	ENST00000273691.3	-	6	1286	c.1181C>T	c.(1180-1182)cCt>cTt	p.P394L	ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000462014.1_Missense_Mutation_p.P406L|ILDR1_ENST00000344209.5_Missense_Mutation_p.P438L|ILDR1_ENST00000393631.1_Missense_Mutation_p.P349L	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	438						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GCTCCTGAAAGGAGGGTGGCT	0.662000													5	30					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31273112	31273112	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:31273112G>A	ENST00000544665.3	+	2	199	c.128G>A	c.(127-129)gGa>gAa	p.G43E	ITGAM_ENST00000287497.8_Missense_Mutation_p.G43E	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	43					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						CAGCTTCAGGGATCCAGGTGA	0.488000													4	16					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89653814	89653814	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:89653814C>T	ENST00000371953.3	+	2	1469	c.112C>T	c.(112-114)Cct>Tct	p.P38S		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	38	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(8)|p.P38S(5)|p.Y27fs*1(2)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TATGGGATTTCCTGCAGAAAG	0.284000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			14	32					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30011131	30011131	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:30011131C>T	ENST00000346128.6	-	21	3689	c.3215G>A	c.(3214-3216)cGa>cAa	p.R1072Q	TJP1_ENST00000545208.2_Missense_Mutation_p.R992Q|TJP1_ENST00000400011.2_Missense_Mutation_p.R996Q|TJP1_ENST00000356107.6_Missense_Mutation_p.R1072Q	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	1072					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TTCATAGTTTCGAGAAAACTG	0.488000													31	149					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55962486	55962486	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:55962486G>A	ENST00000263923.4	-	19	2933	c.2638C>T	c.(2638-2640)Cga>Tga	p.R880*		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	880	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ATGAGAGCTCGATGCTCACTG	0.458000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			23	15					0	0	1	0	0
MCCC2	64087	broad.mit.edu	37	5	70900256	70900256	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:70900256C>T	ENST00000340941.6	+	6	714	c.585C>T	c.(583-585)ttC>ttT	p.F195F	MCCC2_ENST00000323375.8_Silent_p.F195F|MCCC2_ENST00000509358.2_Silent_p.F195F|MCCC2_ENST00000510895.2_3'UTR	NM_022132.4	NP_071415.1	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-CoA carboxylase 2 (beta)	195	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			endometrium(2)|kidney(15)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	30		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GCCGTACATTCTATAATCAGG	0.363000													24	38					0	0	1	0	0
DEFA6	1671	broad.mit.edu	37	8	6782433	6782433	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:6782433G>A	ENST00000297436.2	-	2	250	c.210C>T	c.(208-210)ttC>ttT	p.F70F		NM_001926.3	NP_001917.1	Q01524	DEF6_HUMAN	defensin, alpha 6, Paneth cell-specific	70					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				lung(4)	4			STAD - Stomach adenocarcinoma(24;0.0322)	COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		AATGGCAAGTGAAAGCCCTTG	0.493000													13	20					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4924567	4924567	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:4924567C>T	ENST00000396658.4	+	14	2859	c.2156C>T	c.(2155-2157)gCg>gTg	p.A719V	UBN1_ENST00000545171.1_Missense_Mutation_p.A719V|UBN1_ENST00000262376.6_Missense_Mutation_p.A719V|UBN1_ENST00000590769.1_Missense_Mutation_p.A719V	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	719					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						AGGAACTTTGCGAAGCCTAGT	0.517000													125	239					0	0	1	0	0
MTMR4	9110	broad.mit.edu	37	17	56581467	56581467	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:56581467G>A	ENST00000323456.5	-	14	1724	c.1600C>T	c.(1600-1602)Ctt>Ttt	p.L534F	MTMR4_ENST00000579925.1_Intron	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	534	Myotubularin phosphatase.					cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCAGCTCGAAGGAGCGCCCAC	0.512000													30	132					0	0	1	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47076519	47076519	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:47076519C>T	ENST00000290341.3	+	2	558	c.224C>T	c.(223-225)cCc>cTc	p.P75L	IGF2BP1_ENST00000431824.2_Missense_Mutation_p.P75L|IGF2BP1_ENST00000515586.1_3'UTR	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	75	RRM 1.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CATTCGGTGCCCAAAAAACAA	0.493000													20	33					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541612	133541612	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:133541612C>T	ENST00000409261.1	-	14	3145	c.2772G>A	c.(2770-2772)gtG>gtA	p.V924V	NCKAP5_ENST00000317721.6_Silent_p.V924V|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	924							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						AAGGGGATTTCACCCCTGCCT	0.622000													16	51					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46099262	46099262	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:46099262G>A	ENST00000295452.4	-	2	376	c.209C>T	c.(208-210)tCa>tTa	p.S70L		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	70					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.S70L(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTGAAGCAATGAATTCAGAAT	0.383000													12	79					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538936	55538936	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:55538936G>A	ENST00000220676.1	+	4	2642	c.2494G>A	c.(2494-2496)Gat>Aat	p.D832N		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	832					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAAACCCAAAGATTTTTATGC	0.328000													5	69					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133547743	133547743	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:133547743G>A	ENST00000409261.1	-	13	1318	c.945C>T	c.(943-945)tgC>tgT	p.C315C	NCKAP5_ENST00000317721.6_Silent_p.C315C|NCKAP5_ENST00000409213.1_Silent_p.C315C|NCKAP5_ENST00000405974.3_Silent_p.C315C	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	315							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CCAAGCCAGGGCATTTCAAGG	0.493000													8	18					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563733	176563733	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:176563733G>A	ENST00000367662.3	+	3	2157	c.993G>A	c.(991-993)aaG>aaA	p.K331K	PAPPA2_ENST00000367661.3_Silent_p.K331K	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	331					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGAAGGACAAGGGAAAGCGGG	0.552000													18	52					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074848	9074848	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:9074848G>A	ENST00000397910.4	-	3	12801	c.12598C>T	c.(12598-12600)Ctg>Ttg	p.L4200L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4202	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTTCCCCAGGCCAGAGGTC	0.498000													15	30					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653921	159653921	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:159653921G>A	ENST00000297267.9	+	11	2577	c.2377G>A	c.(2377-2379)Gat>Aat	p.D793N	FNDC1_ENST00000340366.6_Missense_Mutation_p.D730N	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	793						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CGGTGACGGCGATAGGGAAGA	0.632000													3	22					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25336983	25336983	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:25336983G>A	ENST00000546682.1	+	0	969				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA|SNORD116-23_ENST00000384645.1_RNA	NR_003361.1																						TGAACAAAATGAGTGAAAACT	0.473000													57	102					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59157865	59157865	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:59157865G>A	ENST00000262717.4	+	2	477	c.79G>A	c.(79-81)Gac>Aac	p.D27N	CDH20_ENST00000538374.1_Missense_Mutation_p.D27N|CDH20_ENST00000536675.2_Missense_Mutation_p.D27N			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	27					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				GGGGCTGATGGACCTTACGAC	0.512000													51	38					0	0	1	0	0
HEATR6	63897	broad.mit.edu	37	17	58147080	58147080	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:58147080G>A	ENST00000184956.6	-	7	947	c.931C>T	c.(931-933)Cca>Tca	p.P311S	HEATR6_ENST00000585976.1_Missense_Mutation_p.P311S	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	311							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			ACCAAAGTTGGTCGAGAAGCA	0.383000													30	45					0	0	1	0	0
HUS1B	135458	broad.mit.edu	37	6	656649	656649	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:656649G>A	ENST00000380907.2	-	1	314	c.296C>T	c.(295-297)tCc>tTc	p.S99F	EXOC2_ENST00000230449.4_Intron|EXOC2_ENST00000448181.3_Intron	NM_148959.3	NP_683762.2	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint homolog b (S. pombe)	99										endometrium(3)|large_intestine(1)|lung(7)	11	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		CAGCTTCAGGGAGGACGCGCC	0.682000													19	15					0	0	1	0	0
MTMR1	8776	broad.mit.edu	37	X	149924334	149924334	+	Silent	SNP	T	T	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:149924334T>G	ENST00000445323.2	+	15	1975	c.1854T>G	c.(1852-1854)ccT>ccG	p.P618P	MTMR1_ENST00000370390.3_Silent_p.P610P|MTMR1_ENST00000544228.1_Silent_p.P610P|MTMR1_ENST00000541925.1_Silent_p.P516P|MTMR1_ENST00000538506.1_3'UTR			Q13613	MTMR1_HUMAN	myotubularin related protein 1	610						plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GGATGAGACCTCAGGTATCTT	0.338000													23	16					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3594308	3594308	+	RNA	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:3594308C>T	ENST00000301749.7	-	0	3198				NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000419350.2_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTCCGTCATCCCCGATGGCGT	0.592000													13	36					0	0	1	0	0
KIF18A	81930	broad.mit.edu	37	11	28116278	28116278	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:28116278A>C	ENST00000263181.6	-	3	685	c.395T>G	c.(394-396)gTg>gGg	p.V132G		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	132	Kinesin-motor.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						TAGATACATCACTCCAGGTTC	0.403000													23	55					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113353089	113353089	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:113353089G>A	ENST00000458497.1	+	11	2665	c.2386G>A	c.(2386-2388)Gaa>Aaa	p.E796K	ALPK1_ENST00000504176.2_Missense_Mutation_p.E718K|ALPK1_ENST00000177648.9_Missense_Mutation_p.E796K	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	796							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AGAAAGCACTGAAGATGCACC	0.483000													9	45					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10436868	10436868	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:10436868G>A	ENST00000245503.5	-	20	2646	c.2262C>T	c.(2260-2262)tcC>tcT	p.S754S	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Silent_p.S754S|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	754	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CAATGTCGATGGATGCAAGGA	0.408000													51	63					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103124627	103124627	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:103124627C>T	ENST00000295269.4	+	5	1745	c.1288C>T	c.(1288-1290)Cga>Tga	p.R430*		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	430					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CAGTGGTGTTCGAGGAGCTGG	0.413000													20	74					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103244823	103244823	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:103244823C>A	ENST00000428762.1	-	23	3275	c.3116G>T	c.(3115-3117)gGg>gTg	p.G1039V	RELN_ENST00000343529.5_Missense_Mutation_p.G1039V|RELN_ENST00000424685.2_Missense_Mutation_p.G1039V	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1039	EGF-like 2.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGAGCCATGCCCACTGCACAT	0.532000													36	62					2.09667e-21	2.15589e-21	1	1	0
PITPNM2	57605	broad.mit.edu	37	12	123475205	123475205	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:123475205G>A	ENST00000280562.5	-	17	2805	c.2600C>T	c.(2599-2601)tCc>tTc	p.S867F	PITPNM2_ENST00000320201.4_Missense_Mutation_p.S819F|PITPNM2_ENST00000542749.1_Missense_Mutation_p.S819F|PITPNM2_ENST00000392428.1_Missense_Mutation_p.S540F			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	819	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GCCCGGCGAGGAGGGGGCGCC	0.662000													18	43					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114278424	114278424	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:114278424G>A	ENST00000357077.4	+	38	8703	c.8650G>A	c.(8650-8652)Gag>Aag	p.E2884K	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.E2851K|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2851					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGAAACATTTGAGAACTTACC	0.393000													6	162					0	0	1	0	0
CSN3	1448	broad.mit.edu	37	4	71114944	71114944	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:71114944C>T	ENST00000304954.3	+	4	403	c.317C>T	c.(316-318)aCt>aTt	p.T106I		NM_005212.2	NP_005203.2	P07498	CASK_HUMAN	casein kappa	106						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						CACCCACCCACTGTGGTACGT	0.463000													37	20					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503257	140503257	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140503257C>T	ENST00000194152.1	+	1	1677	c.1677C>T	c.(1675-1677)ttC>ttT	p.F559F		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		559	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGCCCTTCGTGCTGTACC	0.701000													60	86					0	0	1	0	0
FIS1	51024	broad.mit.edu	37	7	100884135	100884135	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:100884135C>A	ENST00000474120.1	-	2	474	c.67G>T	c.(67-69)Ggc>Tgc	p.G23C	FIS1_ENST00000482199.1_5'UTR|FIS1_ENST00000223136.4_Silent_p.L77L|FIS1_ENST00000442303.1_Missense_Mutation_p.G54C			Q9Y3D6	FIS1_HUMAN	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)	0					apoptosis|mitochondrial fission|peroxisome fission	integral to mitochondrial outer membrane|integral to peroxisomal membrane	protein binding			kidney(1)|large_intestine(2)|lung(1)	4	Lung NSC(181;0.168)|all_lung(186;0.215)					TCCCCACGGCCAGGTAGAAGA	0.592000													41	92					3.61848e-18	3.71021e-18	1	1	0
CFHR2	3080	broad.mit.edu	37	1	196927145	196927145	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:196927145G>A	ENST00000367415.4	+	4	669	c.555G>A	c.(553-555)gaG>gaA	p.E185E	CFHR2_ENST00000476712.1_3'UTR|CFHR2_ENST00000367421.3_Silent_p.E185E	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	185	Sushi 3.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						ATCAACTTGAGGGTAACAATC	0.388000													88	62					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101375261	101375261	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:101375261C>T	ENST00000344327.3	-	2	863	c.439G>A	c.(439-441)Gaa>Aaa	p.E147K	TRPC6_ENST00000532133.1_Missense_Mutation_p.E147K|TRPC6_ENST00000348423.4_Missense_Mutation_p.E147K|TRPC6_ENST00000360497.4_Missense_Mutation_p.E147K	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	147					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TCTGTAATTTCCAGATGCTCA	0.443000													27	29					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124810371	124810371	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:124810371C>T	ENST00000423114.2	-	12	1919	c.1920G>A	c.(1918-1920)gtG>gtA	p.V640V	SLC12A8_ENST00000314584.7_Intron|SLC12A8_ENST00000393469.4_Silent_p.V611V|SLC12A8_ENST00000469902.1_Silent_p.V611V|SLC12A8_ENST00000465475.1_Intron|SLC12A8_ENST00000430155.2_Silent_p.V412V			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	611					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						CCCACTGTATCACAAACATGA	0.483000													6	76					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113421156	113421156	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:113421156G>A	ENST00000297405.5	-	33	5745	c.5501C>T	c.(5500-5502)tCc>tTc	p.S1834F	CSMD3_ENST00000352409.3_Intron|CSMD3_ENST00000455883.2_Missense_Mutation_p.S1730F|CSMD3_ENST00000343508.3_Missense_Mutation_p.S1794F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1834	CUB 10.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ACCTGAATGGGATCCTGAGAG	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			33	163					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123489977	123489977	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:123489977G>A	ENST00000280562.5	-	6	967	c.762C>T	c.(760-762)tcC>tcT	p.S254S	PITPNM2_ENST00000320201.4_Silent_p.S254S|PITPNM2_ENST00000542749.1_Silent_p.S254S|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000546049.1_Silent_p.S254S|PITPNM2_ENST00000451868.2_5'UTR			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	254					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CCATCTTACGGGAAAGCATGA	0.632000													39	181					0	0	1	0	0
LELP1	149018	broad.mit.edu	37	1	153177316	153177316	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:153177316G>A	ENST00000368747.1	+	2	243	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K		NM_001010857.1	NP_001010857.1	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	45	Cys/Pro-rich.									NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|pancreas(1)|prostate(1)	19	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACGCTGTTTCGAAAAGTGCCC	0.572000													125	77					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168101472	168101472	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:168101472G>A	ENST00000409195.1	+	9	3659	c.3570G>A	c.(3568-3570)atG>atA	p.M1190I	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.M968I|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.M1190I	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1015					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CTGTTGAAATGGATATACAAG	0.368000													34	38					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10451190	10451190	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:10451190G>A	ENST00000245503.5	-	3	432	c.48C>T	c.(46-48)ttC>ttT	p.F16F	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Silent_p.F16F|MYH2_ENST00000532183.1_Silent_p.F16F	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	16	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ACTTTCGGAGGAAAGGAGCAG	0.478000													31	43					0	0	1	0	0
NOMO1	23420	broad.mit.edu	37	16	14976520	14976520	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:14976520C>T	ENST00000287667.7	+	26	3268	c.3097C>T	c.(3097-3099)Cat>Tat	p.H1033Y		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	1033						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						GCTCCCCCACCATAGGGTGAT	0.577000													48	141					0	0	1	0	0
OR51A2	401667	broad.mit.edu	37	11	4976794	4976794	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:4976794G>A	ENST00000380371.1	-	1	149	c.150C>T	c.(148-150)atC>atT	p.I50I	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004748.1	NP_001004748.1	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A, member 2	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTCTTGATGATAAAAAGAA	0.443000													13	17					0	0	1	0	0
ROBO3	64221	broad.mit.edu	37	11	124749841	124749841	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:124749841G>A	ENST00000397801.1	+	26	4147	c.3955G>A	c.(3955-3957)Gat>Aat	p.D1319N	ROBO3_ENST00000538940.1_Missense_Mutation_p.D1297N|ROBO3_ENST00000543966.1_Missense_Mutation_p.D82N|ROBO3_ENST00000525482.1_3'UTR	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1319					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GCTCCACCCAGATGGTAAGCA	0.672000													5	2					0	0	1	0	0
GBP3	2635	broad.mit.edu	37	1	89478911	89478911	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:89478911G>A	ENST00000370481.4	-	6	1045	c.825C>T	c.(823-825)tcC>tcT	p.S275S		NM_018284.2	NP_060754.2	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	275						integral to membrane	GTP binding|GTPase activity			breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		TTTTAGTTTTGGAATTGCTAA	0.448000													23	99					0	0	1	0	0
IQSEC1	9922	broad.mit.edu	37	3	12950814	12950814	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:12950814G>A	ENST00000273221.4	-	11	2795	c.2579C>T	c.(2578-2580)tCc>tTc	p.S860F		NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	860	PH.				regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TTCCGCAATGGACTCCCGCAG	0.537000													21	115					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58240811	58240811	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr13:58240811G>A	ENST00000377918.3	+	3	2667	c.2641G>A	c.(2641-2643)Gac>Aac	p.D881N		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	881					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CACGTTTAAGGACCCAGAAAG	0.443000													25	17					0	0	1	0	0
ADRA1B	147	broad.mit.edu	37	5	159344483	159344483	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:159344483G>A	ENST00000306675.3	+	1	694	c.571G>A	c.(571-573)Gat>Aat	p.D191N		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	191					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	GGCACCCAACGATGACAAGGA	0.592000													15	53					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56207499	56207499	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:56207499G>A	ENST00000288221.6	-	4	1379	c.1124C>T	c.(1123-1125)gCt>gTt	p.A375V		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	375						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		AGTCTGGAGAGCCTTCGTCTT	0.473000													13	62					0	0	1	0	0
GPR6	2830	broad.mit.edu	37	6	110300902	110300902	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:110300902C>T	ENST00000414000.2	+	3	871	c.632C>T	c.(631-633)tCc>tTc	p.S211F	GPR6_ENST00000275169.3_Missense_Mutation_p.S196F			P46095	GPR6_HUMAN	G protein-coupled receptor 6	196						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		TGGACCGTGTCCCTAGGCCTG	0.697000													8	30					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332756	70332756	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:70332756G>A	ENST00000338508.4	-	32	3644	c.3645C>T	c.(3643-3645)tcC>tcT	p.S1215S	SHANK2_ENST00000449833.2_Silent_p.S619S|SHANK2_ENST00000409161.1_Silent_p.S618S|SHANK2_ENST00000423696.2_Silent_p.S835S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	835					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGGCCAGCGGGGAGCTGGGAT	0.667000													40	34					0	0	1	0	0
STARD6	147323	broad.mit.edu	37	18	51855781	51855781	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:51855781G>A	ENST00000581310.1	-	8	788	c.415C>T	c.(415-417)Cca>Tca	p.P139S	STARD6_ENST00000580990.2_Intron|STARD6_ENST00000307844.3_Missense_Mutation_p.P139S			P59095	STAR6_HUMAN	StAR-related lipid transfer (START) domain containing 6	139	START.				lipid transport		lipid binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)	8				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		TTTGAAGATGGAGGATATTCT	0.318000													84	57					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79034487	79034487	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:79034487G>A	ENST00000446378.2	+	2	9930	c.9899G>A	c.(9898-9900)gGt>gAt	p.G3300D		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3300						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAACAGAAAGGTGTTTATGGG	0.478000													30	108					0	0	1	0	0
ASGR2	433	broad.mit.edu	37	17	7010461	7010461	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:7010461C>T	ENST00000380952.2	-	7	785	c.521G>A	c.(520-522)aGg>aAg	p.R174K	ASGR2_ENST00000355035.5_Missense_Mutation_p.R174K|ASGR2_ENST00000446679.2_Missense_Mutation_p.R155K|ASGR2_ENST00000254850.7_Missense_Mutation_p.R150K	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172.1|NP_001188281.1|NP_550434.1	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	174					cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	GCAGCAGGTCCTTTGGGAGCC	0.662000													26	64					0	0	1	0	0
ARHGEF37	389337	broad.mit.edu	37	5	149003640	149003640	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:149003640G>A	ENST00000333677.6	+	10	1564	c.1401G>A	c.(1399-1401)acG>acA	p.T467T		NM_001001669.2	NP_001001669.2	A1IGU5	ARH37_HUMAN	Rho guanine nucleotide exchange factor (GEF) 37	467					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(5)|lung(6)|ovary(1)|prostate(2)|stomach(3)	17						TGGGCCGGACGAGTAACCAGC	0.582000													24	41					0	0	1	0	0
AFTPH	54812	broad.mit.edu	37	2	64779313	64779313	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:64779313C>T	ENST00000422803.1	+	2	1019	c.705C>T	c.(703-705)gcC>gcT	p.A235A	AFTPH_ENST00000238856.4_Silent_p.A235A|AFTPH_ENST00000238855.7_Silent_p.A235A|AFTPH_ENST00000409933.1_Silent_p.A235A			Q6ULP2	AFTIN_HUMAN	aftiphilin	235					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						CAGATTTTGCCACATTTTCCA	0.358000													14	39					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183474319	183474319	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:183474319C>T	ENST00000305135.5	+	12	1589	c.1394C>T	c.(1393-1395)tCc>tTc	p.S465F		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	465					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TAATAAGGTTCCCCAATATCA	0.448000													74	57					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50916399	50916399	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:50916399G>A	ENST00000313478.7	-	12	1685	c.1404C>T	c.(1402-1404)ttC>ttT	p.F468F	TRPM7_ENST00000560955.1_Silent_p.F468F	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	468					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		GAATGGTAAGGAATTTATGCA	0.338000													13	19					0	0	1	0	0
CMTM4	146223	broad.mit.edu	37	16	66657376	66657376	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:66657376G>A	ENST00000330687.4	-	3	574	c.393C>T	c.(391-393)ttC>ttT	p.F131F	CMTM4_ENST00000563952.1_Silent_p.F102F|CMTM4_ENST00000394106.2_Silent_p.F131F	NM_178818.2|NM_181521.2	NP_848933.1|NP_852662.1	Q8IZR5	CKLF4_HUMAN	CKLF-like MARVEL transmembrane domain containing 4	131	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			cervix(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0811)|Epithelial(162;0.214)		TAAAGAAAAGGAAAGCGCTGA	0.423000													10	30					0	0	1	0	0
TF	7018	broad.mit.edu	37	3	133494362	133494362	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:133494362G>A	ENST00000402696.3	+	15	2258	c.1773G>A	c.(1771-1773)gaG>gaA	p.E591E	TF_ENST00000264998.3_Silent_p.E464E	NM_001063.3	NP_001054.1	P02787	TRFE_HUMAN	transferrin	591	Transferrin-like 2.			E -> Q (in Ref. 12; AA sequence).	cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(7)|large_intestine(13)|liver(2)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	AACCTGTGGAGGAGTATGCGA	0.498000													25	215					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834450	125834450	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:125834450G>A	ENST00000299308.3	+	2	513	c.505G>A	c.(505-507)Gaa>Aaa	p.E169K	TMEM132B_ENST00000418253.2_3'UTR	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	169						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TGAGGCCAGGGAAGTGGCAGC	0.592000													44	89					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558506	129558506	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:129558506C>T	ENST00000422113.2	-	9	3540	c.3214G>A	c.(3214-3216)Gac>Aac	p.D1072N	TMEM132D_ENST00000389441.4_Missense_Mutation_p.D610N	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	1072						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CACTTAATGTCATCCTCGCTA	0.498000													36	103					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126544706	126544706	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:126544706G>A	ENST00000339582.2	-	4	1567	c.759C>T	c.(757-759)atC>atT	p.I253I	GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000444921.2_Silent_p.I253I|GRM8_ENST00000405249.1_Silent_p.I253I|GRM8_ENST00000358373.3_Silent_p.I253I			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	253					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GTTCACGTGGGATTTTCTGTG	0.388000										HNSCC(24;0.065)			42	55					0	0	1	0	0
TRBV5-5	28610	broad.mit.edu	37	7	142149006	142149006	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:142149006G>A	ENST00000390372.3	-	0	271																											CTATAGTTAGGGAACTGGCGA	0.527000													72	132					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539808	56539808	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:56539808C>T	ENST00000390649.3	+	7	2209	c.2209C>T	c.(2209-2211)Cgg>Tgg	p.R737W		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	737						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCGGAAAATTCGGGTGGATGT	0.498000													66	127					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137485338	137485338	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:137485338G>A	ENST00000254900.5	-	23	3640	c.3269C>T	c.(3268-3270)tCc>tTc	p.S1090F		NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	1090					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAGCTTTGAGGAGGTAGCATG	0.408000													15	23					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121994742	121994742	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:121994742G>A	ENST00000498619.1	+	5	1899	c.1461G>A	c.(1459-1461)ggG>ggA	p.G487G	CASR_ENST00000490131.1_Silent_p.G487G|CASR_ENST00000296154.5_Silent_p.G487G	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	487					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	ACCTGGTGGGGAACTATTCCA	0.488000													72	50					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101728986	101728986	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:101728986G>A	ENST00000342239.3	-	3	245	c.154C>T	c.(154-156)Ccc>Tcc	p.P52S	DNMBP_ENST00000324109.4_Missense_Mutation_p.P52S			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	52	SH3 1.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		AAACTGCTGGGGAATTGTCCT	0.373000													14	15					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112786338	112786338	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:112786338G>A	ENST00000295408.4	+	19	3154	c.2897G>A	c.(2896-2898)gGg>gAg	p.G966E	MERTK_ENST00000409780.1_Missense_Mutation_p.G790E|MERTK_ENST00000421804.2_Missense_Mutation_p.G966E			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	966					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.G966V(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						GTTAGGAATGGGGTCTCCTGG	0.537000													10	51					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39486953	39486953	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:39486953G>A	ENST00000265707.5	+	7	628	c.583G>A	c.(583-585)Gct>Act	p.A195T	ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.A195T	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	195	Peptidase M12B.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AGTGGAAAAAGCTTTGGTAAG	0.318000													6	17					0	0	1	0	0
KRT37	8688	broad.mit.edu	37	17	39577167	39577167	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:39577167C>T	ENST00000225550.3	-	7	1312	c.1313G>A	c.(1312-1314)gGg>gAg	p.G438E	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	438	Tail.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				AGAGGGAGACCCACCGGTGAC	0.572000													10	32					0	0	1	0	0
GPR87	53836	broad.mit.edu	37	3	151012942	151012942	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:151012942C>T	ENST00000260843.4	-	3	556	c.92G>A	c.(91-93)gGa>gAa	p.G31E	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron|MED12L_ENST00000491549.1_Intron	NM_023915.3	NP_076404.3	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	31						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(6)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	19			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTGTTCTTTCCTGGCCCGTC	0.483000													12	82					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106067895	106067895	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:106067895G>A	ENST00000390540.2	-	0	490																											TGAGGGTGGTGGCTGGTAAGG	0.627000													12	87					0	0	1	0	0
TNFRSF13B	23495	broad.mit.edu	37	17	16855866	16855866	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:16855866C>T	ENST00000261652.2	-	2	105	c.93G>A	c.(91-93)atG>atA	p.M31I	TNFRSF13B_ENST00000437538.2_Intron|TNFRSF13B_ENST00000579315.1_Missense_Mutation_p.M31I|TNFRSF13B_ENST00000583789.1_Intron|TNFRSF13B_ENST00000581616.2_5'UTR	NM_012452.2	NP_036584.1	O14836	TR13B_HUMAN	tumor necrosis factor receptor superfamily, member 13B	31					cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding|receptor activity	p.M31I(1)		endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|skin(1)	16						GGCAGGATCTCATAGCCACCC	0.617000									IgA Deficiency, Selective				29	37					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166003504	166003504	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:166003504G>A	ENST00000360093.3	-	12	1907	c.1416C>T	c.(1414-1416)ttC>ttT	p.F472F	SCN3A_ENST00000283254.7_Silent_p.F472F|SCN3A_ENST00000409101.3_Silent_p.F472F	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	472						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CTATTCCACTGAAATCTCTTG	0.423000													47	54					0	0	1	0	0
ZNF274	10782	broad.mit.edu	37	19	58722937	58722937	+	Silent	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:58722937C>A	ENST00000326804.4	+	8	1320	c.861C>A	c.(859-861)acC>acA	p.T287T	ZNF274_ENST00000424679.2_Silent_p.T182T|ZNF274_ENST00000597818.1_3'UTR|ZNF274_ENST00000345813.3_Silent_p.T255T	NM_133502.1	NP_598009.1	Q96GC6	ZN274_HUMAN	zinc finger protein 274	288	KRAB 2.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)|skin(1)	21		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		AGCCAGTGACCTTCCAGGATG	0.582000													65	196					8.3131e-28	8.57215e-28	1	1	0
CR1L	1379	broad.mit.edu	37	1	207890896	207890896	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:207890896C>T	ENST00000508064.2	+	11	1562	c.1502C>T	c.(1501-1503)tCt>tTt	p.S501F		NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	501	Sushi 8.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						AAAGAAGTATCTTACACATGT	0.483000													32	154					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61615955	61615955	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:61615955C>T	ENST00000583023.1	+	8	1897	c.1886C>T	c.(1885-1887)tCc>tTc	p.S629F	KCNH6_ENST00000314672.5_Missense_Mutation_p.S629F|KCNH6_ENST00000456941.2_Missense_Mutation_p.S576F|KCNH6_ENST00000581784.1_Missense_Mutation_p.S576F	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	629					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	GACGTGCTCTCCACCCTCTAC	0.682000													20	22					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63417109	63417109	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr14:63417109C>T	ENST00000322893.7	-	7	1379	c.1111G>A	c.(1111-1113)Gga>Aga	p.G371R	KCNH5_ENST00000420622.2_Missense_Mutation_p.G371R|KCNH5_ENST00000394968.1_Missense_Mutation_p.G313R|KCNH5_ENST00000394964.2_Missense_Mutation_p.G313R	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	371					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TCGTAGTCTCCGATGCTATAC	0.502000													17	65					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36724045	36724045	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:36724045T>A	ENST00000244751.2	-	13	1510	c.886A>T	c.(886-888)Aag>Tag	p.K296*	CPNE5_ENST00000393189.2_Nonsense_Mutation_p.K4*|CPNE5_ENST00000459703.1_5'UTR	NM_020939.1	NP_065990.1	Q9HCH3	CPNE5_HUMAN	copine V	296										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(4)|liver(1)|lung(9)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25						ACGTATTTCTTTTTCTTCATT	0.517000													6	17					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83126513	83126513	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:83126513C>T	ENST00000329312.4	+	3	149	c.112C>T	c.(112-114)Ccc>Tcc	p.P38S		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	38					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TTTGACATTTCCCAAACCACT	0.299000													20	13					0	0	1	0	0
PROCR	10544	broad.mit.edu	37	20	33764077	33764077	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:33764077C>T	ENST00000216968.4	+	3	511	c.429C>T	c.(427-429)ttC>ttT	p.F143F	EDEM2_ENST00000540582.1_Intron	NM_006404.3	NP_006395.2	Q9UNN8	EPCR_HUMAN	protein C receptor, endothelial	143					antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity			breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	TTGTGAGTTTCCGGCCGGAGA	0.602000													43	140					0	0	1	0	0
SHROOM3	57619	broad.mit.edu	37	4	77700274	77700274	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:77700274C>T	ENST00000296043.6	+	11	6888	c.5935C>T	c.(5935-5937)Cct>Tct	p.P1979S	RP11-359D14.3_ENST00000449007.1_RNA	NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1979					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			TGAGCCCATTCCTGCTGGGGG	0.517000													9	83					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57059626	57059626	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:57059626C>T	ENST00000436936.1	+	6	996	c.771C>T	c.(769-771)ttC>ttT	p.F257F	NLRC5_ENST00000308149.7_Silent_p.F257F|NLRC5_ENST00000539144.1_Silent_p.F257F|NLRC5_ENST00000262510.6_Silent_p.F257F			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	257	NACHT.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				AGGCCCTGTTCCTTTTTGAAT	0.577000													48	102					0	0	1	0	0
RTKN2	219790	broad.mit.edu	37	10	63957983	63957983	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:63957983G>A	ENST00000373789.3	-	12	1610	c.1514C>T	c.(1513-1515)cCc>cTc	p.P505L	RTKN2_ENST00000315289.2_Intron|RTKN2_ENST00000395265.1_Intron	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	505					signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					AGGAGGAAGGGGAGCTTGTCT	0.398000													64	61					0	0	1	0	0
ELMOD1	55531	broad.mit.edu	37	11	107506466	107506466	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:107506466C>T	ENST00000265840.7	+	6	660	c.395C>T	c.(394-396)cCc>cTc	p.P132L	ELMOD1_ENST00000531234.1_Missense_Mutation_p.P126L|ELMOD1_ENST00000443271.2_Missense_Mutation_p.P132L	NM_018712.3	NP_061182.3	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1	132					phagocytosis	cytoskeleton	GTPase activator activity			endometrium(2)|large_intestine(5)|liver(2)|lung(7)|pancreas(2)|prostate(1)	19		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		TCTGATAATCCCCAACATGAA	0.458000													4	21					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6204140	6204140	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:6204140G>A	ENST00000262450.3	-	12	1977	c.1878C>T	c.(1876-1878)atC>atT	p.I626I	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	626	Chromo 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CGATGTCATCGATCTCCCAGG	0.592000													69	79					0	0	1	0	0
KIF6	221458	broad.mit.edu	37	6	39330257	39330257	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:39330257G>C	ENST00000287152.7	-	17	1993	c.1899C>G	c.(1897-1899)gaC>gaG	p.D633E	KIF6_ENST00000373215.3_Missense_Mutation_p.D616E|KIF6_ENST00000373213.4_Missense_Mutation_p.D472E|KIF6_ENST00000541946.1_Missense_Mutation_p.D84E|KIF6_ENST00000394362.1_Missense_Mutation_p.D84E|KIF6_ENST00000538893.1_Missense_Mutation_p.D577E|KIF6_ENST00000229913.5_Missense_Mutation_p.D84E|KIF6_ENST00000373216.3_Missense_Mutation_p.D633E	NM_145027.4	NP_659464.3	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	633					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(16)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						CCTCCTGCTGGTCTGGCATCA	0.522000											OREG0017415	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	93					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488439	108488439	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:108488439G>A	ENST00000408999.3	+	20	4056	c.3979G>A	c.(3979-3981)Gaa>Aaa	p.E1327K	RGPD4_ENST00000354986.4_Missense_Mutation_p.E1327K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1327					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TGTTACTCAAGAAGAAGAGAG	0.393000													116	137					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97771850	97771850	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:97771850G>A	ENST00000370192.3	-	17	2162	c.2062C>T	c.(2062-2064)Cca>Tca	p.P688S	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	688					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ACCAGCTCTGGATCCTGTTCA	0.433000													25	97					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123260486	123260486	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:123260486C>T	ENST00000264501.4	+	72	12648	c.12275C>T	c.(12274-12276)cCt>cTt	p.P4092L	KIAA1109_ENST00000388738.3_Missense_Mutation_p.P4092L			Q2LD37	K1109_HUMAN	KIAA1109	4092					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						ACTACATATCCTGCAGAGACT	0.413000													11	68					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140476315	140476315	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140476315G>A	ENST00000194155.4	+	1	2089	c.1941G>A	c.(1939-1941)aaG>aaA	p.K647K		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		647	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTGGTCAAGGACAATGGCG	0.716000													21	82					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48142308	48142308	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:48142308C>T	ENST00000405493.2	-	12	1255	c.1046G>A	c.(1045-1047)gGc>gAc	p.G349D	RAPGEF3_ENST00000171000.4_Missense_Mutation_p.G349D|RAPGEF3_ENST00000389212.3_Missense_Mutation_p.G391D|RAPGEF3_ENST00000548919.1_Missense_Mutation_p.G349D|RAPGEF3_ENST00000449771.2_Missense_Mutation_p.G391D|RAPGEF3_ENST00000395358.3_Missense_Mutation_p.G391D|RAPGEF3_ENST00000549151.1_Missense_Mutation_p.G349D	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	349					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CTCTGGGGTGCCAGACATCAC	0.517000													11	21					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28914146	28914146	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr18:28914146G>A	ENST00000257192.4	+	8	1198	c.986G>A	c.(985-987)gGa>gAa	p.G329E		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	329	Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			ACAAATGTGGGAATTTTAAAG	0.274000													9	44					0	0	1	0	0
HEATR6	63897	broad.mit.edu	37	17	58121392	58121392	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:58121392G>A	ENST00000184956.6	-	20	3094	c.3078C>T	c.(3076-3078)gtC>gtT	p.V1026V	HEATR6_ENST00000585976.1_Silent_p.V914V	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	1026							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			TCTTCCCCGGGACGGAAAGGG	0.532000													29	116					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124335454	124335454	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:124335454C>T	ENST00000409039.3	+	34	5793	c.5768C>T	c.(5767-5769)tCc>tTc	p.S1923F		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1923	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGGAGATTTCCCTGGACTCC	0.632000													15	31					0	0	1	0	0
RP11-344E13.3	0	broad.mit.edu	37	17	20805938	20805938	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:20805938G>A	ENST00000577537.1	+	0	1122				RP11-344E13.3_ENST00000417232.2_RNA|RP11-344E13.3_ENST00000577860.1_RNA|RP11-344E13.3_ENST00000583962.1_RNA|RP11-344E13.3_ENST00000439794.2_RNA																							TTCCCGGTCAGAAAGACCCCG	0.592000													5	36					0	0	1	0	0
TELO2	9894	broad.mit.edu	37	16	1551673	1551673	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:1551673C>T	ENST00000262319.6	+	11	1650	c.1371C>T	c.(1369-1371)ctC>ctT	p.L457L		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	457						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				GCACGTCCCTCGTTCCAGCCA	0.607000													28	64					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966551	41966551	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:41966551G>A	ENST00000298919.7	+	10	1578	c.1190G>A	c.(1189-1191)gGg>gAg	p.G397E	PDZRN4_ENST00000539469.2_Missense_Mutation_p.G399E|PDZRN4_ENST00000402685.2_Missense_Mutation_p.G657E			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	657							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TGCAATCAAGGGGAGCAAGAG	0.448000													13	80					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3224645	3224645	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:3224645G>A	ENST00000520002.1	-	21	3582	c.3027C>T	c.(3025-3027)atC>atT	p.I1009I	CSMD1_ENST00000602723.1_Silent_p.I1009I|CSMD1_ENST00000400186.3_Silent_p.I1009I|CSMD1_ENST00000602557.1_Silent_p.I1009I|CSMD1_ENST00000542608.1_Silent_p.I1008I|CSMD1_ENST00000539096.1_Silent_p.I1008I|CSMD1_ENST00000537824.1_Silent_p.I1008I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1009	CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGCCTGCCTTGATCGTATGAG	0.478000													3	15					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57515255	57515255	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:57515255C>T	ENST00000374900.4	+	11	1609	c.1489C>T	c.(1489-1491)Cct>Tct	p.P497S	FAAH2_ENST00000491179.1_3'UTR	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	497						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						CAAAGGACTCCCTTTAGGCAT	0.507000										HNSCC(52;0.14)			13	19					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32074047	32074047	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:32074047C>T	ENST00000438447.1	+	18	3223	c.2835C>T	c.(2833-2835)ctC>ctT	p.L945L	PDZD2_ENST00000282493.3_Silent_p.L945L			O15018	PDZD2_HUMAN	PDZ domain containing 2	945					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						AAGCCAGTCTCCCCGGAAGCC	0.592000													38	81					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039935	31039935	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:31039935G>A	ENST00000355537.3	+	4	3556	c.3409G>A	c.(3409-3411)Gga>Aga	p.G1137R		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGAGCCTGATGGAAAGGCCCA	0.517000													28	42					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42808403	42808403	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:42808403C>T	ENST00000514985.1	-	2	309	c.53G>A	c.(52-54)gGa>gAa	p.G18E	SEPP1_ENST00000507920.1_Missense_Mutation_p.G18E|SEPP1_ENST00000506577.1_Missense_Mutation_p.G18E|SEPP1_ENST00000509276.1_5'UTR|SEPP1_ENST00000511224.1_Missense_Mutation_p.G18E	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1	18					response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						GCTCTCTGTTCCTCCCGATGG	0.512000													40	13					0	0	1	0	0
GALNTL5	168391	broad.mit.edu	37	7	151716751	151716751	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr7:151716751G>T	ENST00000392800.2	+	9	1451	c.1197G>T	c.(1195-1197)aaG>aaT	p.K399N	GALNTL5_ENST00000431418.2_Missense_Mutation_p.K399N	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	399						Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		TTCTTCGAAAGCCTGGTCTGA	0.378000													35	59					1.57019e-19	1.61227e-19	1	1	0
ZMYND11	10771	broad.mit.edu	37	10	226028	226028	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:226028C>T	ENST00000397962.3	+	2	504	c.76C>T	c.(76-78)Cgg>Tgg	p.R26W	ZMYND11_ENST00000381604.4_5'UTR|ZMYND11_ENST00000402736.1_Missense_Mutation_p.R26W|ZMYND11_ENST00000381591.1_Missense_Mutation_p.R26W|ZMYND11_ENST00000602682.1_Missense_Mutation_p.R26W|ZMYND11_ENST00000397959.3_Missense_Mutation_p.R26W|ZMYND11_ENST00000558098.2_Missense_Mutation_p.R26W|ZMYND11_ENST00000509513.2_Missense_Mutation_p.R26W|ZMYND11_ENST00000381602.4_5'UTR|ZMYND11_ENST00000403354.1_Missense_Mutation_p.R26W|ZMYND11_ENST00000381584.1_5'UTR|ZMYND11_ENST00000381607.4_5'UTR|ZMYND11_ENST00000309776.4_5'UTR			Q15326	ZMY11_HUMAN	zinc finger, MYND-type containing 11	486					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	24		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		TGAGATTATACGGAACCAGAA	0.403000													3	61					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685886	125685886	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:125685886C>T	ENST00000371126.1	-	1	948	c.706G>A	c.(706-708)Gag>Aag	p.E236K		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	236								p.E236*(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						AGACCCACCTCGCTATGCCAG	0.652000													32	27					0	0	1	0	0
AK5	26289	broad.mit.edu	37	1	77987611	77987611	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:77987611G>A	ENST00000344720.5	+	12	2359	c.1333G>A	c.(1333-1335)Gaa>Aaa	p.E445K	AK5_ENST00000354567.2_Missense_Mutation_p.E471K	NM_012093.3	NP_036225.2	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5	471					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|prostate(1)|skin(2)|stomach(1)	40						GAAGCAAGGGGAAGAGTTCGG	0.542000													14	21					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31901648	31901648	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:31901648C>T	ENST00000556679.1	+	4	490	c.435C>T	c.(433-435)ccC>ccT	p.P145P	CFB_ENST00000477310.1_Intron|C2_ENST00000452323.2_Silent_p.P84P|C2_ENST00000469372.1_Intron|C2_ENST00000442278.2_Silent_p.P75P|C2_ENST00000418949.2_Silent_p.P207P|CFB_ENST00000456570.1_Silent_p.P145P|C2_ENST00000299367.5_Silent_p.P207P			P00751	CFAB_HUMAN	complement factor B	221	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CCACAGAACCCTACTCTTATG	0.632000													44	55					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	105011054	105011054	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chrX:105011054C>T	ENST00000372582.1	+	11	2217	c.1461C>T	c.(1459-1461)ttC>ttT	p.F487F	IL1RAPL2_ENST00000538500.1_Silent_p.F92F|IL1RAPL2_ENST00000344799.4_Silent_p.F487F	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	487	TIR.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GGAGTATTTTCGAACTGGAAA	0.388000													39	22					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66259558	66259558	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:66259558C>T	ENST00000405643.1	+	2	449	c.71C>T	c.(70-72)cCa>cTa	p.P24L	MAST4_ENST00000406374.1_Intron|MAST4_ENST00000403666.1_Intron|MAST4_ENST00000403625.2_Intron|MAST4_ENST00000490016.2_Intron|MAST4_ENST00000404260.3_Intron|MAST4_ENST00000406039.1_Intron|MAST4_ENST00000407621.1_Missense_Mutation_p.P24L			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1296						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGCCTGAGTCCAACCCCATCC	0.493000													13	89					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640452	57640452	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:57640452A>G	ENST00000254181.4	+	4	863	c.409A>G	c.(409-411)Att>Gtt	p.I137V	USP29_ENST00000598197.1_Missense_Mutation_p.I137V	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	137					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATTTTACAGCATTTGTAACAA	0.373000													15	49					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17409101	17409101	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:17409101G>A	ENST00000375486.4	-	10	1160	c.1097C>T	c.(1096-1098)cCc>cTc	p.P366L	PADI2_ENST00000466151.1_5'UTR|PADI2_ENST00000444885.2_Missense_Mutation_p.P250L|PADI2_ENST00000375481.1_Missense_Mutation_p.P366L	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	366					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CAGCACCACGGGGAAGCCTTT	0.547000													23	46					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46996743	46996743	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:46996743C>A	ENST00000371253.2	-	2	270	c.55G>T	c.(55-57)Ggt>Tgt	p.G19C	GPR110_ENST00000449332.2_5'UTR|GPR110_ENST00000371243.2_Missense_Mutation_p.G19C	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	19					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						AGGAAGCCACCGTGGCCGTCA	0.512000													52	66					3.76343e-11	3.848e-11	1	1	0
CLRN3	119467	broad.mit.edu	37	10	129681983	129681983	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:129681983A>C	ENST00000368671.3	-	2	548	c.386T>G	c.(385-387)gTg>gGg	p.V129G		NM_152311.3	NP_689524.1	Q8NCR9	CLRN3_HUMAN	clarin 3	129						integral to membrane				endometrium(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6		all_epithelial(44;0.00168)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)|Colorectal(57;0.235)				CCAGGTGTACACCCCCGTCGG	0.572000													22	22					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140729878	140729878	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:140729878C>T	ENST00000523390.1	+	1	51	c.51C>T	c.(49-51)ccC>ccT	p.P17P	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACTGTTTCCCTTCCTGCTGT	0.522000											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	20					0	0	1	0	0
TMEM189	387521	broad.mit.edu	37	20	48699376	48699376	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr20:48699376G>A	ENST00000557021.1	-	8	1202	c.1042C>T	c.(1042-1044)Cgg>Tgg	p.R348W	UBE2V1_ENST00000340309.3_Missense_Mutation_p.R148W|UBE2V1_ENST00000371657.5_Missense_Mutation_p.R83W|UBE2V1_ENST00000371677.3_Missense_Mutation_p.R148W|TMEM189-UBE2V1_ENST00000341698.2_Missense_Mutation_p.R348W|UBE2V1_ENST00000420027.2_Missense_Mutation_p.R81W|UBE2V1_ENST00000415862.2_Missense_Mutation_p.R81W|UBE2V1_ENST00000396059.3_5'UTR|UBE2V1_ENST00000371674.3_Missense_Mutation_p.R125W	NM_199203.2	NP_954673.1			transmembrane protein 189											breast(1)|endometrium(2)|large_intestine(3)|lung(2)	8			BRCA - Breast invasive adenocarcinoma(9;3.02e-07)			ATTAGGCGCCGAAGCTCTTGC	0.443000													24	124					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3299597	3299597	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:3299597C>T	ENST00000219596.1	-	3	1133	c.1094G>A	c.(1093-1095)gGa>gAa	p.G365E	MEFV_ENST00000541159.1_Missense_Mutation_p.G154E|MEFV_ENST00000339854.4_Missense_Mutation_p.G185E|MEFV_ENST00000536379.1_Missense_Mutation_p.G154E	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	365					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	GCTTAGGCTTCCCGGGCTCTT	0.647000													14	42					0	0	1	0	0
PSMD3	5709	broad.mit.edu	37	17	38152539	38152539	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:38152539C>T	ENST00000264639.4	+	10	1598	c.1424C>T	c.(1423-1425)gCc>gTc	p.A475V	PSMD3_ENST00000541736.1_Missense_Mutation_p.A337V	NM_002809.3	NP_002800.2	O43242	PSMD3_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	475					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Colorectal(19;0.000442)					CCCCAGCTAGCCTTCCACCAG	0.557000													103	165					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113816709	113816709	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:113816709C>T	ENST00000260191.2	+	9	1433	c.1176C>T	c.(1174-1176)ctC>ctT	p.L392L	HTR3B_ENST00000537778.1_Silent_p.L381L	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	392	HA-stretch.				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GCAACTACCTCCAAACTCAGG	0.557000													26	23					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36872992	36872992	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:36872992C>T	ENST00000429976.2	-	21	8197	c.7950G>A	c.(7948-7950)atG>atA	p.M2650I	TRANK1_ENST00000301807.6_Missense_Mutation_p.M2100I|TRANK1_ENST00000428977.2_Missense_Mutation_p.M2100I			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2650					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CCAGTTCATCCATCTCATCCT	0.532000													6	18					0	0	1	0	0
NXPH3	11248	broad.mit.edu	37	17	47656441	47656441	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr17:47656441G>A	ENST00000328741.5	+	2	900	c.538G>A	c.(538-540)Gag>Aag	p.E180K	NXPH3_ENST00000513748.1_Missense_Mutation_p.E180K	NM_007225.2	NP_009156.2	O95157	NXPH3_HUMAN	neurexophilin 3	180	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				endometrium(2)|large_intestine(3)|lung(4)|pancreas(1)|skin(2)	12	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					GATGGAGTGGGAGAAGGTAGA	0.602000													36	106					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215802250	215802250	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:215802250G>A	ENST00000272895.7	-	51	7745	c.7526C>T	c.(7525-7527)cCa>cTa	p.P2509L	ABCA12_ENST00000389661.4_Missense_Mutation_p.P2191L|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2509					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GTATGTTTTTGGAAAGTGCAG	0.458000													10	42					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43044283	43044283	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr15:43044283G>T	ENST00000267890.6	-	14	3269	c.3161C>A	c.(3160-3162)cCa>cAa	p.P1054Q		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1054					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AACTGGCCTTGGAATTTTGCT	0.493000													19	71					0.000132079	0.000132809	1	1	0
ZNF598	90850	broad.mit.edu	37	16	2049600	2049600	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:2049600G>A	ENST00000563630.1	-	9	2027	c.1785C>T	c.(1783-1785)ccC>ccT	p.P595P	ZNF598_ENST00000562103.1_Silent_p.P595P|ZNF598_ENST00000431526.1_Silent_p.P650P			Q86UK7	ZN598_HUMAN	zinc finger protein 598	650						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						GGAGCCCAGGGGGTTCCTTGG	0.736000													24	26					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157556184	157556184	+	Silent	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr1:157556184C>T	ENST00000271532.1	-	6	1044	c.909G>A	c.(907-909)ggG>ggA	p.G303G	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	303	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CCAGCATCTCCCCTTCAACAG	0.602000													27	112					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180372594	180372594	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr3:180372594C>T	ENST00000273654.4	-	13	1757	c.1138G>A	c.(1138-1140)Gca>Aca	p.A380T	CCDC39_ENST00000442201.2_Missense_Mutation_p.A296T			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	296					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCCTGATATGCCGTTCTACAT	0.348000													11	19					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29364696	29364696	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:29364696G>A	ENST00000383555.2	+	1	281	c.220G>A	c.(220-222)Gtg>Atg	p.V74M	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V74L(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						TTACTCTACGGTGACACTGCC	0.458000													46	52					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67265011	67265011	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:67265011G>A	ENST00000356404.3	-	13	2147	c.1922C>T	c.(1921-1923)cCc>cTc	p.P641L	PITPNM1_ENST00000534749.1_Missense_Mutation_p.P641L|PITPNM1_ENST00000436757.2_Missense_Mutation_p.P641L	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	641					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity	p.P641_S644delPEGS(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						AGAGCCCTCGGGCTCAGGACT	0.672000													6	196					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144994511	144994511	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr8:144994511G>A	ENST00000322810.4	-	32	10058	c.9889C>T	c.(9889-9891)Cga>Tga	p.R3297*	PLEC_ENST00000345136.3_Nonsense_Mutation_p.R3160*|PLEC_ENST00000527096.1_Nonsense_Mutation_p.R3183*|PLEC_ENST00000356346.3_Nonsense_Mutation_p.R3146*|PLEC_ENST00000357649.2_Nonsense_Mutation_p.R3164*|PLEC_ENST00000398774.2_Nonsense_Mutation_p.R3128*|PLEC_ENST00000354589.3_Nonsense_Mutation_p.R3160*|PLEC_ENST00000436759.2_Nonsense_Mutation_p.R3187*|PLEC_ENST00000354958.2_Nonsense_Mutation_p.R3138*	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3297	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						AGGCAGCCTCGGGCGCAGGCG	0.721000													23	9					0	0	1	0	0
SPATA31C1	441452	broad.mit.edu	37	9	90535766	90535766	+	RNA	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:90535766C>T	ENST00000602681.1	+	0	1670																											GATCATCTTTCCCGCCAAAGG	0.552000													127	43					0	0	1	0	0
GYPA	2993	broad.mit.edu	37	4	145040890	145040890	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:145040890C>T	ENST00000360771.4	-	3	296	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	GYPA_ENST00000512064.1_Missense_Mutation_p.E61K|GYPB_ENST00000283126.7_Intron|GYPA_ENST00000503627.1_Intron|RP11-673E1.4_ENST00000506982.1_RNA|GYPA_ENST00000512789.1_Intron|GYPA_ENST00000504786.1_Intron|GYPA_ENST00000535709.1_Missense_Mutation_p.E35K|GYPA_ENST00000324022.10_Missense_Mutation_p.E28K	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	61					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					TCTGAAACTTCATGAGCTCTA	0.418000													31	29					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538455	4538455	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:4538455G>A	ENST00000306390.6	-	2	1001	c.541C>T	c.(541-543)Ccc>Tcc	p.P181S	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	181						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCAGCCCGGGGGGCAGTTTC	0.622000													65	188					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58207172	58207172	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr11:58207172G>A	ENST00000302572.2	-	1	474	c.453C>T	c.(451-453)ttC>ttT	p.F151F		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ATGCATTCAGGAAACCACAGA	0.463000													25	34					0	0	1	0	0
GATAD2A	54815	broad.mit.edu	37	19	19613204	19613204	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:19613204C>T	ENST00000404158.1	+	13	2061	c.1643C>T	c.(1642-1644)cCg>cTg	p.P548L	GATAD2A_ENST00000252577.5_Missense_Mutation_p.P522L|GATAD2A_ENST00000360315.3_Missense_Mutation_p.P547L|GATAD2A_ENST00000537887.1_Missense_Mutation_p.P176L|GATAD2A_ENST00000358713.3_Missense_Mutation_p.P547L|GATAD2A_ENST00000429563.2_Missense_Mutation_p.P350L			Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	547					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13						ACGTTCAGTCCGTCACCCAAA	0.667000													16	142					0	0	1	0	0
C5orf54	63920	broad.mit.edu	37	5	159821898	159821898	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr5:159821898G>C	ENST00000408953.3	-	2	1107	c.600C>G	c.(598-600)atC>atG	p.I200M	C5orf54_ENST00000523213.1_Missense_Mutation_p.I200M	NM_022090.3	NP_071373.2	Q8IZ13	CE054_HUMAN	chromosome 5 open reading frame 54	200								p.I200I(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	12						attcttctacgatctctcttt	0.408000													3	50					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	54025323	54025323	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr6:54025323C>T	ENST00000514921.1	+	7	2445	c.2332C>T	c.(2332-2334)Cct>Tct	p.P778S	MLIP_ENST00000274897.5_Missense_Mutation_p.P254S|MLIP_ENST00000370877.2_Intron|MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000509997.1_Intron|MLIP_ENST00000358276.5_Intron|MLIP_ENST00000370876.2_Intron|MLIP_ENST00000502396.1_Missense_Mutation_p.P789S			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	254						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						GCTCTATTTTCCTGCACAGCT	0.418000													6	44					0	0	1	0	0
LOC344967	344967	broad.mit.edu	37	4	40045585	40045585	+	RNA	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:40045585G>A	ENST00000381811.2	-	0	564					NR_027277.1																						AGCCAGAGCGGCCACACAGCG	0.622000													10	7					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99013544	99013544	+	Silent	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:99013544G>A	ENST00000393504.1	+	8	2328	c.1911G>A	c.(1909-1911)ctG>ctA	p.L637L	CNGA3_ENST00000272602.2_Silent_p.L637L|CNGA3_ENST00000409937.1_Silent_p.L641L|CNGA3_ENST00000436404.2_Silent_p.L619L	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	637					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						GGTCCTCCCTGGACACCCTGC	0.597000													12	50					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41691554	41691554	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr4:41691554G>A	ENST00000313860.7	+	25	3079	c.3025G>A	c.(3025-3027)Gga>Aga	p.G1009R	LIMCH1_ENST00000512946.1_Missense_Mutation_p.G983R|LIMCH1_ENST00000514096.1_Missense_Mutation_p.G823R|LIMCH1_ENST00000513024.1_Missense_Mutation_p.G836R|LIMCH1_ENST00000508501.1_Missense_Mutation_p.G982R|RP11-227F19.5_ENST00000506475.1_RNA|LIMCH1_ENST00000512632.1_Missense_Mutation_p.G906R|LIMCH1_ENST00000381753.4_Missense_Mutation_p.G816R|LIMCH1_ENST00000503057.1_Missense_Mutation_p.G1393R|LIMCH1_ENST00000396595.3_Missense_Mutation_p.G828R|LIMCH1_ENST00000509277.1_Missense_Mutation_p.G842R|LIMCH1_ENST00000511496.1_Missense_Mutation_p.G823R|LIMCH1_ENST00000512820.1_Missense_Mutation_p.G995R	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	1009					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						GTCTATAAGTGGAAAGAAGCT	0.383000													28	10					0	0	1	0	0
OR7E62P	26479	broad.mit.edu	37	2	71283122	71283123	+	RNA	INS	-	-	T	rs35074164		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr2:71283122_71283123insT	ENST00000434990.1	-	0	61																											GGCACCACCCCCAGGAGTGGTG	0.530													3	3	---	---	---	---					
CDKN2A	1029	broad.mit.edu	37	9	21971122	21971123	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:21971122_21971123insT	ENST00000579755.1	-	2	570_571	c.278_279insA	c.(277-279)cccfs	p.P93fs	CDKN2A_ENST00000494262.1_Frame_Shift_Ins_p.P28fs|CDKN2A_ENST00000579122.1_Frame_Shift_Ins_p.P79fs|CDKN2A_ENST00000578845.2_Frame_Shift_Ins_p.P28fs|CDKN2A_ENST00000446177.1_Frame_Shift_Ins_p.P79fs|CDKN2A_ENST00000498628.2_Frame_Shift_Ins_p.P28fs|CDKN2A_ENST00000304494.5_Frame_Shift_Ins_p.P79fs|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000361570.3_Frame_Shift_Ins_p.P134fs|CDKN2A_ENST00000497750.1_Frame_Shift_Ins_p.P28fs|CDKN2A_ENST00000479692.2_Frame_Shift_Ins_p.P28fs|CDKN2A_ENST00000530628.2_Frame_Shift_Ins_p.P93fs|CDKN2A_ENST00000498124.1_Frame_Shift_Ins_p.P79fs			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	0			T -> A (in non-small cell lung carcinoma).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.T79I(2)|p.L65fs*38(1)|p.T79fs*37(1)|p.0(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.T79fs*41(1)|p.E61_L94del(1)|p.A68fs*3(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CACGGGTCGGGTGAGAGTGGCG	0.728		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			36	19	---	---	---	---					
GPR107	57720	broad.mit.edu	37	9	132839657	132839660	+	Splice_Site	DEL	AGTA	AGTA	-			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr9:132839657_132839660delAGTA	ENST00000372406.1	+	4	893	c.386_splice	c.e4+1	p.129_splice	GPR107_ENST00000347136.6_Splice_Site_p.129_splice|GPR107_ENST00000372410.3_Splice_Site_p.129_splice	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	129						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				TCCAGAAGTGAGTAAGTAATTCTA	0.412													9	46	---	---	---	---					
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr10:30316501_30316503delCTG	ENST00000375377.1	-	3	2675_2677	c.2574_2576delCAG	c.(2572-2577)agt>ag	p.SS858del		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	858	Ser-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ACTCTCCTCActgctgctgctgc	0.571													7	95	---	---	---	---					
RP11-273B20.3	0	broad.mit.edu	37	12	7338794	7338794	+	RNA	DEL	G	G	-	rs34548221		TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr12:7338794delG	ENST00000545794.1	-	0	279				RP11-273B20.3_ENST00000543061.1_RNA																							cctgttgagaggggggactga	0.502													3	3	---	---	---	---					
PMM2	5373	broad.mit.edu	37	16	8904969	8904969	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr16:8904969delA	ENST00000268261.4	+	5	447	c.381delA	c.(379-381)ttfs	p.L127fs	PMM2_ENST00000566983.1_Frame_Shift_Del_p.L100fs|PMM2_ENST00000537352.1_Frame_Shift_Del_p.L2fs|PMM2_ENST00000569958.1_Intron|PMM2_ENST00000539622.1_Frame_Shift_Del_p.L44fs	NM_000303.2	NP_000294.1	O15305	PMM2_HUMAN	phosphomannomutase 2	127					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			breast(3)|cervix(1)|endometrium(2)|large_intestine(1)|ovary(1)|skin(1)	9						ATGGGATGTTAAACGTGTCCC	0.408													2	4	---	---	---	---					
NOTCH3	4854	broad.mit.edu	37	19	15303285	15303285	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D3-A5GN-06A-11D-A27K-08	TCGA-D3-A5GN-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8715150d-bd53-413a-b69e-1e8402bb6f51	25e1a5a6-ca70-4f0f-87d9-be8c09a0e194	g.chr19:15303285delG	ENST00000263388.2	-	3	318	c.243delC	c.(241-243)ccfs	p.P81fs		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	81	EGF-like 2.		Missing (in CADASIL).		Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CTGAGTGACAGGGGTCCTCCA	0.677													9	16	---	---	---	---