Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CMTR1	23070	broad.mit.edu	37	6	37446287	37446287	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr6:37446287G>T	ENST00000373451.4	+	22	2420	c.2256G>T	c.(2254-2256)agG>agT	p.R752S		NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		752	Interaction with POLR2A.|WW.				mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						ACATCGTCAGGACAGTGAATG	0.602000													19	141					7.41877e-09	3.70648e-06	2.27731e-05	1	0
HNRNPH2	3188	broad.mit.edu	37	X	100667886	100667886	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chrX:100667886G>T	ENST00000316594.5	+	2	988	c.910G>T	c.(910-912)Gat>Tat	p.D304Y		NM_001032393.2|NM_001199973.1|NM_001199974.1|NM_019597.4	NP_001027565.1|NP_001186902.1|NP_001186903.1|NP_062543.1	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2 (H')	304	2 X 16 AA Gly-rich approximate repeats.|RRM 3.				nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(3)|large_intestine(2)|lung(6)|skin(1)	12						CACTGAGAATGATATTTATAA	0.448000													20	98					3.51602e-12	1.83648e-09	1.15919e-05	1	0
MED12	9968	broad.mit.edu	37	X	70342382	70342382	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chrX:70342382G>A	ENST00000333646.6	+	9	1472	c.1273G>A	c.(1273-1275)Gag>Aag	p.E425K	MED12_ENST00000374102.1_Missense_Mutation_p.E425K|MED12_ENST00000374080.3_Missense_Mutation_p.E425K	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	425					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					GCGGGAGATCGAGCAGCAGAT	0.488000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						7	66					0	0	5.18039e-06	0	0
PRC1	9055	broad.mit.edu	37	15	91517847	91517847	+	Silent	SNP	G	G	T			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr15:91517847G>T	ENST00000361188.5	-	10	2529	c.1318C>A	c.(1318-1320)Cga>Aga	p.R440R	PRC1_ENST00000361919.3_Silent_p.R440R|PRC1_ENST00000394249.3_Silent_p.R440R|PRC1_ENST00000442656.2_Silent_p.R399R|PRC1-AS1_ENST00000554388.1_RNA			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	440	Spectrin-fold.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					TTCTCCAATCGATGCATCTCC	0.443000													21	1398					1.49906e-05	0.00637988	1.49906e-05	1	0
KDM6B	23135	broad.mit.edu	37	17	7750643	7750643	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr17:7750643C>T	ENST00000254846.5	+	10	1519	c.1130C>T	c.(1129-1131)gCa>gTa	p.A377V	KDM6B_ENST00000448097.2_Missense_Mutation_p.A377V	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	377	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						GTTTCACCAGCAGCAACCACC	0.662000													42	244					0	0	1.39061e-05	0	0
ERC1	23085	broad.mit.edu	37	12	1137146	1137146	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr12:1137146G>A	ENST00000397203.2	+	2	483	c.77G>A	c.(76-78)cGt>cAt	p.R26H	ERC1_ENST00000546231.2_Missense_Mutation_p.R26H|ERC1_ENST00000355446.5_Missense_Mutation_p.R26H|ERC1_ENST00000589028.1_Missense_Mutation_p.R26H|ERC1_ENST00000543086.3_Missense_Mutation_p.R26H|ERC1_ENST00000360905.4_Missense_Mutation_p.R26H			Q8IUD2	RB6I2_HUMAN	ELKS/RAB6-interacting/CAST family member 1	26					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			NS(1)|breast(2)|cervix(2)|endometrium(2)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			AGGCTTCCACGTTCCCCTCGC	0.572000													7	48					0	0	1.12685e-05	0	0
C21orf59	56683	broad.mit.edu	37	21	33976511	33976511	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr21:33976511A>G	ENST00000382549.4	-	4	800	c.458T>C	c.(457-459)gTt>gCt	p.V153A	C21ORF59_ENST00000607686.1_Silent_p.C130C|C21orf59_ENST00000540881.1_Missense_Mutation_p.V97A|C21orf59_ENST00000290155.3_Missense_Mutation_p.V153A			P57076	CU059_HUMAN	chromosome 21 open reading frame 59	153						cytosol|nucleus				endometrium(2)|large_intestine(1)|prostate(1)|skin(1)	5						CATGGGGTAAACAATCATCAC	0.502000													24	59					0	0	3.83957e-06	0	0
FOLH1B	219595	broad.mit.edu	37	11	89392753	89392753	+	RNA	SNP	A	A	C			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr11:89392753A>C	ENST00000532352.1	+	0	576							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TTCTCTACTCAGACCCTGCTG	0.453000													3	14					0	0	1.23904e-05	0	0
SDK1	221935	broad.mit.edu	37	7	3998595	3998595	+	Silent	SNP	C	C	A			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr7:3998595C>A	ENST00000404826.2	+	8	1322	c.1183C>A	c.(1183-1185)Cgg>Agg	p.R395R	SDK1_ENST00000389531.3_Silent_p.R395R	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	395	Ig-like C2-type 4.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GCCCGAGAGTCGGATTTCAGC	0.468000													14	139					9.31168e-06	0.00428002	9.31168e-06	1	0
PARP2	10038	broad.mit.edu	37	14	20813596	20813596	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr14:20813596C>G	ENST00000527915.1	+	3	290	c.285C>G	c.(283-285)gaC>gaG	p.D95E	RP11-203M5.2_ENST00000528210.1_RNA|PARP2_ENST00000250416.5_Missense_Mutation_p.D95E|PARP2_ENST00000429687.3_Missense_Mutation_p.D82E			Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase 2	95					protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity	p.D46D(1)		central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	15	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		CTCCTGTGGACCCAGAGTGTA	0.463000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					7	98					0	0	1.12685e-05	0	0
ZNF324B	388569	broad.mit.edu	37	19	58966439	58966439	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr19:58966439T>C	ENST00000391696.1	+	3	1030	c.98T>C	c.(97-99)tTc>tCc	p.F33S	ZNF324B_ENST00000336614.4_Intron|ZNF324B_ENST00000545523.1_Intron			Q6AW86	Z324B_HUMAN	zinc finger protein 324B	184	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CTCTTCTTTTTCCCTAAGCTT	0.607000													6	12					0	0	5.9392e-07	0	0
L1CAM	3897	broad.mit.edu	37	X	153130422	153130422	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chrX:153130422G>A	ENST00000370060.1	-	23	3089	c.2900C>T	c.(2899-2901)tCc>tTc	p.S967F	L1CAM_ENST00000361981.3_Missense_Mutation_p.S962F|L1CAM_ENST00000370055.1_Missense_Mutation_p.S962F|L1CAM_ENST00000370057.3_Missense_Mutation_p.S967F|L1CAM_ENST00000361699.4_Missense_Mutation_p.S967F|L1CAM_ENST00000543994.1_Missense_Mutation_p.S969F|L1CAM_ENST00000538883.1_Missense_Mutation_p.S969F	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	967	Fibronectin type-III 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AAGGTTGAAGGACAGTTGCCC	0.657000													36	239					0	0	2.86225e-05	0	0
SLC39A9	55334	broad.mit.edu	37	14	69922518	69922518	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr14:69922518C>G	ENST00000031146.4	+	5	1108	c.430C>G	c.(430-432)Cac>Gac	p.H144D	SLC39A9_ENST00000556605.1_Missense_Mutation_p.H210D|SLC39A9_ENST00000557046.1_Missense_Mutation_p.H187D|SLC39A9_ENST00000555245.1_3'UTR|SLC39A9_ENST00000336643.5_Missense_Mutation_p.H210D			Q9NUM3	S39A9_HUMAN	solute carrier family 39, member 9	210					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|skin(1)|stomach(1)	14				all cancers(60;0.00299)|BRCA - Breast invasive adenocarcinoma(234;0.0145)|OV - Ovarian serous cystadenocarcinoma(108;0.0373)		AATCAGAAAGCACTTGCTGGT	0.428000													7	36					0	0	2.0095e-06	0	0
DGAT2	84649	broad.mit.edu	37	11	75480152	75480152	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr11:75480152G>A	ENST00000228027.7	+	1	376	c.116G>A	c.(115-117)aGa>aAa	p.R39K	DGAT2_ENST00000605608.1_3'UTR|DGAT2_ENST00000376262.3_Missense_Mutation_p.R39K	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	39					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					GGGTCTGGGAGATGGGGTGAG	0.667000													42	280					0	0	2.47226e-05	0	0
KDM5B	10765	broad.mit.edu	37	1	202736112	202736112	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr1:202736112G>C	ENST00000367265.3	-	5	1817	c.653C>G	c.(652-654)tCt>tGt	p.S218C	KDM5B_ENST00000367264.2_Missense_Mutation_p.S218C	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	218					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						AGGCTGCACAGACTGCCTCTG	0.483000													6	34					0	0	5.9392e-07	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209212720	209212720	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr2:209212720A>G	ENST00000264380.4	+	35	5505	c.5347A>G	c.(5347-5349)Acc>Gcc	p.T1783A		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1783	PIPK.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						CAAGGAGGGGACCGAGAATCA	0.443000													4	76					0	0	1.23904e-05	0	0
TMEM147	10430	broad.mit.edu	37	19	36036834	36036834	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr19:36036834C>A	ENST00000222284.5	+	2	267	c.122C>A	c.(121-123)aCc>aAc	p.T41N	TMEM147_ENST00000392205.1_Missense_Mutation_p.T41N|TMEM147_ENST00000392204.2_5'UTR|AD000090.2_ENST00000589137.1_RNA	NM_032635.3	NP_116024.1	Q9BVK8	TM147_HUMAN	transmembrane protein 147	41						endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCTGGAGTCACCTACCTCTTT	0.682000													5	38					1.23904e-05	0.00547608	1.23904e-05	1	0
GPSM3	63940	broad.mit.edu	37	6	32159488	32159488	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr6:32159488G>T	ENST00000375040.3	-	3	735	c.343C>A	c.(343-345)Cag>Aag	p.Q115K	GPSM3_ENST00000487761.1_Missense_Mutation_p.Q112K|GPSM3_ENST00000375043.3_Missense_Mutation_p.Q115K	NM_001276501.1	NP_001263430.1	Q9Y4H4	GPSM3_HUMAN	G-protein signaling modulator 3	115	GoLoco 2.				signal transduction	cytoplasm	GTPase activator activity|protein binding			large_intestine(1)	1						TGTCTTACCTGGTGACTGAGG	0.597000													16	433					3.52763e-06	0.001689	3.52763e-06	1	0
TTN	7273	broad.mit.edu	37	2	179614932	179614932	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr2:179614932delT	ENST00000360870.5	-	46	12417	c.12195delA	c.(12193-12195)cafs	p.Q4065fs	TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3454							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCCTTTTGCTTGGTCAAACA	0.423													2	4	---	---	---	---					
ZC2HC1A	51101	broad.mit.edu	37	8	79598774	79598775	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr8:79598774_79598775delAA	ENST00000263849.4	+	4	385_386	c.283_284delAA	c.(283-285)afs	p.K95fs	ZC2HC1A_ENST00000521176.1_3'UTR	NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	95																	AAGAGCAGCTAAAGGCCTTGAT	0.376													2	4	---	---	---	---					
MESP2	145873	broad.mit.edu	37	15	90320121	90320144	+	In_Frame_Del	DEL	AGGGGCAGGGGCAAGGGCAGGGGC	AGGGGCAGGGGCAAGGGCAGGGGC	-	rs56192595		TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr15:90320121_90320144delAGGGGCAGGGGCAAGGGCAGGGGC	ENST00000341735.3	+	1	533_556	c.533_556delAGGGGCAGGGGCAAGGGCAGGGGC	c.(532-558)gag>g	p.EGQGQGQGQ178del	MESP2_ENST00000560219.1_Intron|MESP2_ENST00000558723.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	178					Notch signaling pathway	nucleus	DNA binding	p.Q198_G205delQGQGQGQG(1)		kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			ACGCaggcggaggggcaggggcaagggcaggggcaggggcaggg	0.777													5	8	---	---	---	---					
RP11-51O6.1	0	broad.mit.edu	37	16	61089302	61089302	+	RNA	DEL	C	C	-	rs80101907		TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr16:61089302delC	ENST00000591758.1	-	0	566																											GCttcttcttctttttttttt	0.244													2	4	---	---	---	---					
CHERP	10523	broad.mit.edu	37	19	16640581	16640583	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-D3-A2JB-06A-11D-A196-08	TCGA-D3-A2JB-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1d485de5-b864-412e-9632-01486f9c3f71	a3e70dee-f653-4d31-94ca-12ec9def742e	g.chr19:16640581_16640583delTGC	ENST00000546361.2	-	8	1156_1158	c.1005_1007delGCA	c.(1003-1008)caa>ca	p.QQ339del	CHERP_ENST00000198939.6_In_Frame_Del_p.QQ350del|CTD-3222D19.2_ENST00000409035.1_Intron	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	339	Gln-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						ctgctgctgttgctgctgctgct	0.670													7	93	---	---	---	---