Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPR112	139378	broad.mit.edu	37	X	135431586	135431586	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chrX:135431586G>A	ENST00000394143.1	+	6	6012	c.5721G>A	c.(5719-5721)atG>atA	p.M1907I	GPR112_ENST00000412101.1_Missense_Mutation_p.M1702I|GPR112_ENST00000394141.1_Missense_Mutation_p.M1702I|GPR112_ENST00000370652.1_Missense_Mutation_p.M1907I|GPR112_ENST00000287534.4_Missense_Mutation_p.M1844I	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1907					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CCAATGAGATGGAAACAGAGA	0.433000													16	91					0	0	0.004007	0	0
C8A	731	broad.mit.edu	37	1	57341848	57341848	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:57341848G>A	ENST00000361249.3	+	4	526	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	144	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CAGCCAGTATGAACCAATTCC	0.507000													14	49					0	0	0.003163	0	0
KCNC1	3746	broad.mit.edu	37	11	17793228	17793228	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr11:17793228C>T	ENST00000379472.3	+	2	617	c.587C>T	c.(586-588)tCc>tTc	p.S196F	KCNC1_ENST00000265969.6_Missense_Mutation_p.S196F	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	196						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GCCTTCGCTTCCCTCTTCTTC	0.577000													11	50					0	0	0.008291	0	0
NANOG	79923	broad.mit.edu	37	12	7947128	7947128	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr12:7947128G>A	ENST00000229307.4	+	3	709	c.490G>A	c.(490-492)Ggt>Agt	p.G164S	NANOG_ENST00000526286.1_Missense_Mutation_p.G164S	NM_024865.2	NP_079141.2	Q9H9S0	NANOG_HUMAN	Nanog homeobox	164					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14				Kidney(36;0.0872)		GAATAGCAATGGTGTGACGCA	0.423000													5	10					0	0	0.000602	0	0
ARHGAP8	23779	broad.mit.edu	37	22	45243920	45243920	+	Silent	SNP	C	C	T	rs139004299	by1000genomes	TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr22:45243920C>T	ENST00000517296.3	+	14	1368	c.1368C>T	c.(1366-1368)ctC>ctT	p.L456L	ARHGAP8_ENST00000389774.2_Silent_p.L277L|ARHGAP8_ENST00000336963.4_Silent_p.L246L|ARHGAP8_ENST00000356099.6_Silent_p.L246L|ARHGAP8_ENST00000389773.5_Silent_p.L368L|PRR5-ARHGAP8_ENST00000361473.5_Silent_p.L377L|PRR5-ARHGAP8_ENST00000352766.7_Silent_p.L456L					Rho GTPase activating protein 8											breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(9)|prostate(1)|skin(7)	29		all_neural(38;0.00409)|Ovarian(80;0.00976)|Glioma(61;0.0649)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0204)		TCCAGAGGCTCTACAACCAAG	0.682000													8	31					0	0	0.003080	0	0
MSI1	4440	broad.mit.edu	37	12	120794704	120794704	+	Splice_Site	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr12:120794704C>T	ENST00000257552.2	-	9	741		c.e9+1		MSI1_ENST00000546622.1_Splice_Site	NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1						nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCGCGCATACCCAGCATGCC	0.642000											OREG0022190	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	53					0	0	0.001168	0	0
MPP1	4354	broad.mit.edu	37	X	154020428	154020428	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chrX:154020428C>T	ENST00000413259.3	-	3	537	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	MPP1_ENST00000369534.3_Missense_Mutation_p.E79K|MPP1_ENST00000462825.1_Intron|MPP1_ENST00000393531.1_Missense_Mutation_p.E79K	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	79					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATGGGCTCTTCTGTGACCTTC	0.567000													19	81					0	0	0.008871	0	0
OR4A5	81318	broad.mit.edu	37	11	51411637	51411637	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr11:51411637G>A	ENST00000319760.6	-	1	811	c.759C>T	c.(757-759)ttC>ttT	p.F253F		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				TAACATATATGAAAATACAGG	0.393000													4	28					0	0	0.009096	0	0
MEP1A	4224	broad.mit.edu	37	6	46800998	46800998	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:46800998C>T	ENST00000230588.4	+	11	1341	c.1332C>T	c.(1330-1332)gtC>gtT	p.V444V		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	444	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			TCTCCCAAGTCCTTGAGAACA	0.493000													24	55					0	0	0.003954	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	49					0	0	0.000602	0	0
KLHL20	27252	broad.mit.edu	37	1	173744862	173744862	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:173744862G>A	ENST00000209884.4	+	10	1655	c.1519G>A	c.(1519-1521)Gac>Aac	p.D507N	KLHL20_ENST00000546011.1_Missense_Mutation_p.D318N	NM_014458.3	NP_055273.2	Q9Y2M5	KLH20_HUMAN	kelch-like family member 20	507					cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			breast(3)|endometrium(6)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|upper_aerodigestive_tract(1)	34						AGTATATCAGGACATGATCTA	0.507000													10	89					0	0	0.008291	0	0
NEURL4	84461	broad.mit.edu	37	17	7226330	7226330	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr17:7226330G>A	ENST00000399464.2	-	15	2545	c.2530C>T	c.(2530-2532)Ctg>Ttg	p.L844L	NEURL4_ENST00000570460.1_Silent_p.L822L|NEURL4_ENST00000315614.7_Silent_p.L844L	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AAGTAGTGCAGGTCGCCCTTG	0.597000													5	35					0	0	0.000602	0	0
DOCK2	1794	broad.mit.edu	37	5	169454944	169454944	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:169454944G>A	ENST00000256935.8	+	34	3539	c.3459G>A	c.(3457-3459)ctG>ctA	p.L1153L	DOCK2_ENST00000520908.1_Silent_p.L645L|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Silent_p.L214L	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1153	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGCAGCTCCTGGAGTCAATGT	0.547000													8	48					0	0	0.004482	0	0
C12orf36	283422	broad.mit.edu	37	12	13526307	13526307	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr12:13526307C>T	ENST00000318426.2	-	3	465	c.248G>A	c.(247-249)tGg>tAg	p.W83*	C12orf36_ENST00000527705.2_Nonsense_Mutation_p.W83*					chromosome 12 open reading frame 36											lung(3)|skin(3)	6				BRCA - Breast invasive adenocarcinoma(232;0.198)		TCGTGCAATCCAGCAGAATGT	0.473000													15	66					0	0	0.003163	0	0
GTSE1	51512	broad.mit.edu	37	22	46708187	46708187	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr22:46708187C>T	ENST00000454366.1	+	5	1124	c.912C>T	c.(910-912)atC>atT	p.I304I		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	285					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		AGCGGGCGATCCCTGTTCCAA	0.582000													6	39					0	0	0.003080	0	0
NOVA1	4857	broad.mit.edu	37	14	26918050	26918050	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr14:26918050C>T	ENST00000539517.2	-	5	956	c.639G>A	c.(637-639)ggG>ggA	p.G213G	NOVA1_ENST00000267422.7_Silent_p.G91G|NOVA1_ENST00000465357.2_Silent_p.G189G	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	216	KH 2.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		GCAAGTTGATCCCATCAGGTT	0.483000													9	65					0	0	0.004482	0	0
DNM3	26052	broad.mit.edu	37	1	172011255	172011255	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:172011255C>T	ENST00000358155.4	+	8	1275	c.1099C>T	c.(1099-1101)Cat>Tat	p.H367Y	DNM3_ENST00000367733.2_Missense_Mutation_p.H367Y|DNM3_ENST00000520906.1_Missense_Mutation_p.H367Y|DNM3_ENST00000355305.5_Missense_Mutation_p.H367Y|DNM3_ENST00000367731.1_Missense_Mutation_p.H367Y	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	367					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TCGTATTTTTCATGAACGCTT	0.358000													10	32					0	0	0.008291	0	0
BSN	8927	broad.mit.edu	37	3	49662694	49662694	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr3:49662694C>T	ENST00000296452.4	+	2	625	c.511C>T	c.(511-513)Ccc>Tcc	p.P171S		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	171					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CACGCTGTGTCCCATATGCAA	0.607000													6	59					0	0	0.003080	0	0
GRIP2	80852	broad.mit.edu	37	3	14563253	14563253	+	RNA	SNP	T	T	G			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr3:14563253T>G	ENST00000273083.3	-	0	673							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CGGGATTCCATCGACACTGAG	0.672000													3	21					0	0	0.004672	0	0
CHGB	1114	broad.mit.edu	37	20	5903298	5903298	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr20:5903298G>A	ENST00000378961.4	+	4	712	c.508G>A	c.(508-510)Gga>Aga	p.G170R		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	170	Poly-Glu.					extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						GGAGGAGGAGGGAGAGAACTA	0.507000													5	26					0	0	0.001168	0	0
EPHB6	2051	broad.mit.edu	37	7	142562286	142562286	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr7:142562286C>T	ENST00000392957.2	+	7	1515	c.728C>T	c.(727-729)cCa>cTa	p.P243L	EPHB6_ENST00000411471.2_Intron|EPHB6_ENST00000442129.1_Missense_Mutation_p.P243L	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	243	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GCTTCCTTTCCAGAGACGCAG	0.667000													37	165					0	0	0.004289	0	0
SNCAIP	9627	broad.mit.edu	37	5	121761206	121761206	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:121761206C>A	ENST00000261367.7	+	7	2731	c.1303C>A	c.(1303-1305)Cca>Aca	p.P435T	SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000379536.2_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.P435T|SNCAIP_ENST00000261368.8_Missense_Mutation_p.P388T|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000503116.2_Missense_Mutation_p.P435T			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	388					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GAAGTTGACTCCAGCAGGCCT	0.498000													10	40					1.58986e-06	1.74772e-06	0.008291	1	0
SLC38A8	146167	broad.mit.edu	37	16	84050128	84050128	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr16:84050128G>A	ENST00000299709.3	-	8	1157	c.1158C>T	c.(1156-1158)ttC>ttT	p.F386F		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	386					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						CCTCACCTGGGAAGATGAAGA	0.562000													5	29					0	0	0.000602	0	0
C11orf82	220042	broad.mit.edu	37	11	82643251	82643251	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr11:82643251C>T	ENST00000533655.1	+	6	1083	c.871C>T	c.(871-873)Ccc>Tcc	p.P291S	C11orf82_ENST00000430323.2_Missense_Mutation_p.P291S|C11orf82_ENST00000329143.3_5'UTR|C11orf82_ENST00000528759.1_3'UTR|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000525388.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	291					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						CTGCCATGATCCCATTCAGGA	0.438000													9	23					0	0	0.004482	0	0
TTI1	9675	broad.mit.edu	37	20	36627679	36627679	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr20:36627679G>A	ENST00000373448.2	-	6	2942	c.2704C>T	c.(2704-2706)Cag>Tag	p.Q902*	TTI1_ENST00000449821.1_Nonsense_Mutation_p.Q902*|TTI1_ENST00000373447.3_Nonsense_Mutation_p.Q902*	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	902							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						GGAAGCAGCTGGTTTTTGTGG	0.537000													6	44					0	0	0.001168	0	0
ITGB5	3693	broad.mit.edu	37	3	124538622	124538622	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr3:124538622G>A	ENST00000296181.4	-	7	1298	c.1002C>T	c.(1000-1002)atC>atT	p.I334I	ITGB5_ENST00000488466.1_Intron	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	334	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		TCACTGCAAAGATGAGGTTGA	0.468000													17	60					0	0	0.006122	0	0
GRIN2A	2903	broad.mit.edu	37	16	9892225	9892225	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr16:9892225G>A	ENST00000396573.2	-	12	2574	c.2265C>T	c.(2263-2265)atC>atT	p.I755I	GRIN2A_ENST00000562109.1_Silent_p.I755I|GRIN2A_ENST00000535259.1_Silent_p.I598I|GRIN2A_ENST00000404927.2_Silent_p.I755I|GRIN2A_ENST00000330684.3_Silent_p.I755I|GRIN2A_ENST00000396575.2_Silent_p.I755I	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	755					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGTGGCAAAGATGTACCCAC	0.537000													12	39					0	0	0.010729	0	0
ADAM9	8754	broad.mit.edu	37	8	38899485	38899485	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr8:38899485G>A	ENST00000487273.2	+	12	1229	c.1151G>A	c.(1150-1152)aGt>aAt	p.S384N		NM_003816.2	NP_003807.1	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9	384	Peptidase M12B.				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			AACTTTAGCAGTTGCAGTGCA	0.368000													13	32					0	0	0.003163	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29907123	29907123	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr16:29907123C>T	ENST00000308713.5	-	4	1097	c.570G>A	c.(568-570)ggG>ggA	p.G190G	SEZ6L2_ENST00000537485.1_Silent_p.G146G|SEZ6L2_ENST00000350527.3_Silent_p.G120G|SEZ6L2_ENST00000346932.5_Intron|SEZ6L2_ENST00000562159.1_Intron	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	190	CUB 1.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGACGGGGCTCCCCAGATCTG	0.552000													12	51					0	0	0.010729	0	0
STRC	161497	broad.mit.edu	37	15	43895496	43895496	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr15:43895496C>T	ENST00000450892.2	-	23	4566	c.4489G>A	c.(4489-4491)Gga>Aga	p.G1497R	STRC_ENST00000541030.1_Missense_Mutation_p.G724R	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1497					sensory perception of sound	cell surface				skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		CCTGGGTCTCCTGCAAATAAT	0.547000													17	44					0	0	0.004007	0	0
ZFHX3	463	broad.mit.edu	37	16	72993636	72993636	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr16:72993636G>A	ENST00000268489.5	-	2	1081	c.409C>T	c.(409-411)Ccg>Tcg	p.P137S	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	137					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GAGCCGTCCGGCTGGTAGACG	0.692000													16	47					0	0	0.004990	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332570	22332570	+	RNA	SNP	T	T	C			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr15:22332570T>C	ENST00000558896.1	+	0	377																											CCCATGCTCATCTGCTCCAAT	0.398000													4	94					0	0	0.009096	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138417790	138417790	+	Missense_Mutation	SNP	C	C	T	rs150912912		TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr7:138417790C>T	ENST00000310018.2	-	17	2022	c.1740G>A	c.(1738-1740)atG>atA	p.M580I	ATP6V0A4_ENST00000393054.1_Missense_Mutation_p.M580I|ATP6V0A4_ENST00000353492.4_Missense_Mutation_p.M580I	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	580			M -> T (in RTADR; dbSNP:rs3807153).		cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GGATAAAAATCATCTCAGGGA	0.428000													5	23					0	0	0.000602	0	0
PHACTR3	116154	broad.mit.edu	37	20	58381145	58381145	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr20:58381145G>A	ENST00000371015.1	+	8	1691	c.1224G>A	c.(1222-1224)agG>agA	p.R408R	PHACTR3_ENST00000395636.2_Silent_p.R367R|PHACTR3_ENST00000395639.4_Silent_p.R297R|PHACTR3_ENST00000541461.1_Silent_p.R367R|PHACTR3_ENST00000361300.4_Silent_p.R297R|PHACTR3_ENST00000359926.3_Silent_p.R405R|PHACTR3_ENST00000355648.4_Silent_p.R367R	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	408						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TGAAGCTAAGGAACCGGCCAA	0.517000													26	122					0	0	0.004656	0	0
CYP20A1	57404	broad.mit.edu	37	2	204111491	204111491	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr2:204111491C>T	ENST00000356079.4	+	3	259	c.136C>T	c.(136-138)Cca>Tca	p.P46S	CYP20A1_ENST00000429815.2_Missense_Mutation_p.P46S|CYP20A1_ENST00000461371.1_Intron	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	46						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						TGGTAATCTTCCAGATATTGT	0.388000													12	77					0	0	0.001855	0	0
PDPR	55066	broad.mit.edu	37	16	70190455	70190455	+	Silent	SNP	C	C	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr16:70190455C>A	ENST00000288050.4	+	19	3270	c.2313C>A	c.(2311-2313)atC>atA	p.I771I	RP11-296I10.3_ENST00000566989.1_RNA|PDPR_ENST00000567046.1_Silent_p.I129I|PDPR_ENST00000568530.1_Silent_p.I771I|PDPR_ENST00000562100.1_3'UTR|PDPR_ENST00000398122.3_Silent_p.I671I|PDPR_ENST00000542659.1_Silent_p.I116I	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	771					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		CCATGTTCATCCTGGACGACC	0.527000													8	107					5.18039e-06	5.65465e-06	0.003080	1	0
OR13C3	138803	broad.mit.edu	37	9	107298150	107298150	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr9:107298150C>T	ENST00000374781.2	-	1	987	c.945G>A	c.(943-945)ggG>ggA	p.G315G		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	315					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						GTGTCACTACCCCATAAAACA	0.373000													10	54					0	0	0.008291	0	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727446	25727446	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:25727446C>T	ENST00000274764.2	+	1	310	c.310C>T	c.(310-312)Ctg>Ttg	p.L104L		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	104					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						GCGCTTGCTACTGCCGGGAGA	0.507000													9	44					0	0	0.004482	0	0
PACS1	55690	broad.mit.edu	37	11	65987258	65987258	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr11:65987258G>A	ENST00000320580.4	+	8	1053	c.1020G>A	c.(1018-1020)cgG>cgA	p.R340R		NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	340					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						TCCTGAAGCGGTTTAAAGTTT	0.478000													3	23					0	0	0.009096	0	0
CNNM4	26504	broad.mit.edu	37	2	97464958	97464958	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr2:97464958C>T	ENST00000377075.2	+	4	1944	c.1846C>T	c.(1846-1848)Ctg>Ttg	p.L616L	CNNM4_ENST00000540067.1_Silent_p.L103L|CNNM4_ENST00000496186.1_3'UTR	NM_020184.3	NP_064569.3	Q6P4Q7	CNNM4_HUMAN	cyclin M4	616					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	20						CATCCTCATCCTGCAGGTGAG	0.597000													18	80					0	0	0.008871	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101794106	101794106	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:101794106C>T	ENST00000506729.1	-	6	1282	c.1111G>A	c.(1111-1113)Gat>Aat	p.D371N	SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000379810.1_Intron|SLCO6A1_ENST00000513675.1_Intron|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.D309N|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.D371N			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	371						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GCACATAAATCCTTGATATTA	0.303000													6	41					0	0	0.001168	0	0
TSC2	7249	broad.mit.edu	37	16	2112524	2112524	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr16:2112524C>T	ENST00000219476.3	+	13	1914	c.1284C>T	c.(1282-1284)tcC>tcT	p.S428S	TSC2_ENST00000568454.1_Silent_p.S439S|TSC2_ENST00000382538.6_Silent_p.S379S|TSC2_ENST00000353929.4_Silent_p.S428S|TSC2_ENST00000401874.2_Silent_p.S428S|TSC2_ENST00000439673.2_Silent_p.S391S|TSC2_ENST00000350773.4_Silent_p.S428S	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	428					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				ACCTGATCTCCTATAGAGCGC	0.602000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				10	19					0	0	0.008291	0	0
LVRN	206338	broad.mit.edu	37	5	115351463	115351463	+	Splice_Site	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:115351463G>A	ENST00000357872.4	+	18	2880		c.e18+1		AQPEP_ENST00000515454.1_Splice_Site	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN							proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										TGAGTAAAAGGTAAGAAGGAA	0.428000													5	20					0	0	0.000602	0	0
ADAM33	80332	broad.mit.edu	37	20	3650273	3650273	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr20:3650273C>T	ENST00000356518.2	-	20	2493	c.2252G>A	c.(2251-2253)gGc>gAc	p.G751D	ADAM33_ENST00000379861.4_Missense_Mutation_p.G751D|ADAM33_ENST00000350009.2_Missense_Mutation_p.G725D|ADAM33_ENST00000466620.1_5'UTR	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	751					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						CCTGTGTGGGCCATCTTTGGG	0.652000													4	19					0	0	0.000602	0	0
PTPRD	5789	broad.mit.edu	37	9	8525030	8525030	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr9:8525030G>A	ENST00000381196.4	-	15	1117	c.574C>T	c.(574-576)Ctt>Ttt	p.L192F	PTPRD_ENST00000537002.1_Missense_Mutation_p.L189F|PTPRD_ENST00000356435.5_Missense_Mutation_p.L192F|PTPRD_ENST00000397606.3_Missense_Mutation_p.L186F|PTPRD_ENST00000540109.1_Missense_Mutation_p.L192F|PTPRD_ENST00000397611.3_Missense_Mutation_p.L189F|PTPRD_ENST00000358503.5_Missense_Mutation_p.L183F|PTPRD_ENST00000486161.1_Missense_Mutation_p.L192F|PTPRD_ENST00000397617.3_Missense_Mutation_p.L186F|PTPRD_ENST00000355233.5_Missense_Mutation_p.L192F|PTPRD_ENST00000360074.4_Missense_Mutation_p.L183F	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	192	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCAATCTGAAGGGCTCCTGTA	0.433000										TSP Lung(15;0.13)			24	115					0	0	0.003954	0	0
HSPA2	3306	broad.mit.edu	37	14	65008497	65008497	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr14:65008497C>T	ENST00000247207.6	+	1	1312	c.930C>T	c.(928-930)gcC>gcT	p.A310A	HSPA2_ENST00000394709.1_Silent_p.A310A	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	310					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		AGCTCAATGCCGACCTCTTTC	0.652000													7	22					0	0	0.001984	0	0
PEX14	5195	broad.mit.edu	37	1	10689675	10689675	+	Silent	SNP	C	C	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:10689675C>A	ENST00000356607.4	+	9	845	c.765C>A	c.(763-765)gcC>gcA	p.A255A	PEX14_ENST00000538836.1_Silent_p.A191A	NM_004565.2	NP_004556.1	O75381	PEX14_HUMAN	peroxisomal biogenesis factor 14	255					negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|protein homooligomerization|protein import into peroxisome matrix|transmembrane transport	integral to membrane|nucleus|peroxisomal membrane|protein complex	protein N-terminus binding|transcription corepressor activity			breast(3)|endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	13	Ovarian(185;0.203)	all_lung(284;6.02e-06)|Lung NSC(185;9.62e-06)|Renal(390;0.000147)|Breast(348;0.000932)|Colorectal(325;0.00215)|Hepatocellular(190;0.00913)|Ovarian(437;0.023)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0292)|Colorectal(212;9.13e-08)|COAD - Colon adenocarcinoma(227;2.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000482)|Kidney(185;0.00174)|KIRC - Kidney renal clear cell carcinoma(229;0.00457)|STAD - Stomach adenocarcinoma(132;0.0249)|READ - Rectum adenocarcinoma(331;0.0419)		GCCCTGCGGCCGTGAACCACC	0.647000													17	42					0.000566183	0.000613695	0.004990	1	0
TSSK1B	83942	broad.mit.edu	37	5	112769724	112769724	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:112769724C>T	ENST00000390666.3	-	1	1004	c.813G>A	c.(811-813)tgG>tgA	p.W271*	MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000383058.4_RNA|CTD-2201G3.1_ENST00000416046.2_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	271	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TGGGCTGCATCCAGCAGTGGC	0.627000													10	36					0	0	0.006214	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142480031	142480031	+	RNA	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr7:142480031G>A	ENST00000603901.1	+	0	163					NR_001296.3																						CCTCATCAGCGAACAGTGGGT	0.577000													19	58					0	0	0.008871	0	0
MYO1F	4542	broad.mit.edu	37	19	8587587	8587587	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr19:8587587C>T	ENST00000338257.8	-	26	3248	c.2981G>A	c.(2980-2982)cGa>cAa	p.R994Q		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	994						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						TGCCCGGGGTCGTCTGCTGGC	0.697000													12	44					0	0	0.001855	0	0
EPHB2	2048	broad.mit.edu	37	1	23111246	23111246	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:23111246T>C	ENST00000400191.3	+	3	506	c.488T>C	c.(487-489)gTg>gCg	p.V163A	EPHB2_ENST00000544305.1_Missense_Mutation_p.V163A|EPHB2_ENST00000374630.3_Missense_Mutation_p.V163A|EPHB2_ENST00000374627.1_Missense_Mutation_p.V157A|EPHB2_ENST00000374632.3_Missense_Mutation_p.V163A	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	163					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		AACACCGAGGTGCGGAGCTTC	0.602000													3	31					0	0	0.004672	0	0
ABCA4	24	broad.mit.edu	37	1	94586584	94586584	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:94586584C>T	ENST00000370225.3	-	1	104	c.18G>A	c.(16-18)caG>caA	p.Q6Q	ABCA4_ENST00000535735.1_Silent_p.Q6Q	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	6					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AAAGCTGTATCTGTCTCACGA	0.488000													9	45					0	0	0.004482	0	0
TKT	7086	broad.mit.edu	37	3	53275209	53275209	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr3:53275209G>A	ENST00000462138.1	-	3	366	c.278C>T	c.(277-279)gCc>gTc	p.A93V	TKT_ENST00000296289.6_Missense_Mutation_p.A46V|TKT_ENST00000423525.2_Missense_Mutation_p.A93V|TKT_ENST00000423516.1_Missense_Mutation_p.A93V			P29401	TKT_HUMAN	transketolase	93					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|transketolase activity			endometrium(5)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17		Prostate(884;0.0959)		BRCA - Breast invasive adenocarcinoma(193;0.000159)|OV - Ovarian serous cystadenocarcinoma(275;0.000314)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)	Thiamine(DB00152)	CTCCGCCTCGGCCAGGAAACC	0.652000													5	34					0	0	0.001168	0	0
LILRP2	79166	broad.mit.edu	37	19	55220650	55220650	+	RNA	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr19:55220650C>T	ENST00000413439.1	+	0	788																											CGCAGCGAGCCCCTGGAGCTG	0.592000													4	14					0	0	0.000602	0	0
DSC3	1825	broad.mit.edu	37	18	28602425	28602425	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr18:28602425C>T	ENST00000434452.1	-	7	973	c.819G>A	c.(817-819)ccG>ccA	p.P273P	DSC3_ENST00000360428.4_Silent_p.P273P	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	273	Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GCATTGTGTCCGGTTCATCTC	0.438000													11	34					0	0	0.010729	0	0
BSN	8927	broad.mit.edu	37	3	49693791	49693791	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr3:49693791C>T	ENST00000296452.4	+	5	6916	c.6802C>T	c.(6802-6804)Ccc>Tcc	p.P2268S		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2268					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AAGTAGATTTCCCATTGCTTC	0.607000													24	84					0	0	0.004656	0	0
SEC23B	10483	broad.mit.edu	37	20	18507119	18507119	+	Missense_Mutation	SNP	C	C	T	rs111758941		TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr20:18507119C>T	ENST00000336714.3	+	8	1369	c.937C>T	c.(937-939)Cgt>Tgt	p.R313C	SEC23B_ENST00000377465.1_Missense_Mutation_p.R313C|SEC23B_ENST00000262544.2_Missense_Mutation_p.R313C|SEC23B_ENST00000377475.3_Missense_Mutation_p.R313C	NM_006363.4|NM_032985.4|NM_032986.3	NP_006354.2|NP_116780.1|NP_116781.1	Q15437	SC23B_HUMAN	Sec23 homolog B (S. cerevisiae)	313			R -> H.		ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	32						GATTCCTATTCGTTCTTGGCA	0.458000													12	45					0	0	0.001855	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				4	33					0	0	0.009096	0	0
BDKRB1	623	broad.mit.edu	37	14	96730313	96730313	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr14:96730313G>A	ENST00000216629.6	+	3	900	c.294G>A	c.(292-294)tgG>tgA	p.W98*	RP11-404P21.3_ENST00000553638.1_RNA|BDKRB1_ENST00000553356.1_Nonsense_Mutation_p.W98*	NM_000710.3	NP_000701.2	P46663	BKRB1_HUMAN	bradykinin receptor B1	98					elevation of cytosolic calcium ion concentration	endoplasmic reticulum|integral to plasma membrane	bradykinin receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(4)|skin(1)|urinary_tract(1)	16		all_cancers(154;0.0677)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.208)|Epithelial(152;0.226)		AGAATATCTGGAACCAGTTTA	0.552000													15	67					0	0	0.004007	0	0
LILRB4	11006	broad.mit.edu	37	19	55177331	55177331	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr19:55177331C>T	ENST00000391736.1	+	9	1138	c.823C>T	c.(823-825)Ctc>Ttc	p.L275F	LILRB4_ENST00000391733.3_Missense_Mutation_p.L275F|LILRB4_ENST00000391734.3_Missense_Mutation_p.L275F|LILRB4_ENST00000270452.2_Missense_Mutation_p.L275F|LILRB4_ENST00000430952.2_Missense_Mutation_p.L275F	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	275						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		tctctccctcctcctcttcct	0.572000													4	16					0	0	0.009096	0	0
PCLO	27445	broad.mit.edu	37	7	82476533	82476533	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr7:82476533G>A	ENST00000423517.2	-	11	14022	c.13685C>T	c.(13684-13686)cCc>cTc	p.P4562L	PCLO_ENST00000333891.8_Missense_Mutation_p.P4562L|PCLO_ENST00000426442.2_5'UTR	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4450					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGAAGTCAAGGGAATTCCATT	0.368000													5	13					0	0	0.001168	0	0
BRWD3	254065	broad.mit.edu	37	X	79936924	79936924	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chrX:79936924A>G	ENST00000373275.4	-	40	4786	c.4570T>C	c.(4570-4572)Ttc>Ctc	p.F1524L	BRWD3_ENST00000473691.1_5'UTR	NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1524										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						TATCCACCGAAGCTCGATGAA	0.388000													7	49					0	0	0.003080	0	0
TRPM1	4308	broad.mit.edu	37	15	31362263	31362263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr15:31362263G>A	ENST00000542188.1	-	3	614	c.301C>T	c.(301-303)Cag>Tag	p.Q101*	TRPM1_ENST00000397795.2_Nonsense_Mutation_p.Q62*|TRPM1_ENST00000559179.1_Nonsense_Mutation_p.Q62*|TRPM1_ENST00000256552.6_Nonsense_Mutation_p.Q84*	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	62					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CCGCCACCCTGGAATTCAAGA	0.507000													63	280					0	0	0.014410	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31146129	31146129	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr7:31146129G>A	ENST00000304166.4	+	16	1527	c.1238G>A	c.(1237-1239)cGa>cAa	p.R413Q	ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.R469Q|ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.R392Q|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.R441Q	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	413					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						GAGATCAAGCGAAAATGGCGA	0.612000													7	33					0	0	0.001984	0	0
CACNA1E	777	broad.mit.edu	37	1	181689360	181689360	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:181689360G>A	ENST00000526775.1	+	14	1935	c.1770G>A	c.(1768-1770)cgG>cgA	p.R590R	CACNA1E_ENST00000367567.4_Silent_p.R197R|CACNA1E_ENST00000360108.3_Silent_p.R590R|CACNA1E_ENST00000358338.5_Silent_p.R541R|CACNA1E_ENST00000367573.2_Silent_p.R590R|CACNA1E_ENST00000367570.1_Silent_p.R590R|CACNA1E_ENST00000357570.5_Silent_p.R541R	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	590					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTTCCCTACGGAATTTGGTGG	0.478000													9	57					0	0	0.008291	0	0
PTHLH	5744	broad.mit.edu	37	12	28116578	28116578	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr12:28116578G>A	ENST00000535992.1	-	3	573	c.227C>T	c.(226-228)tCg>tTg	p.S76L	PTHLH_ENST00000545234.1_Missense_Mutation_p.S76L|PTHLH_ENST00000395872.1_Missense_Mutation_p.S76L|PTHLH_ENST00000395868.3_Missense_Mutation_p.S76L|PTHLH_ENST00000538310.1_Missense_Mutation_p.S76L|PTHLH_ENST00000201015.4_Missense_Mutation_p.S76L|RP11-993B23.3_ENST00000538113.1_RNA|PTHLH_ENST00000354417.3_Missense_Mutation_p.S76L|PTHLH_ENST00000539239.1_Missense_Mutation_p.S76L			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	76					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding	p.S76*(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					GGACACCTCCGAGGTAGCTCT	0.512000													26	132					0	0	0.004656	0	0
HDAC9	9734	broad.mit.edu	37	7	18975448	18975448	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr7:18975448G>A	ENST00000406451.3	+	23	2961	c.2811G>A	c.(2809-2811)acG>acA	p.T937T	HDAC9_ENST00000401921.1_Silent_p.T896T|HDAC9_ENST00000432645.2_Silent_p.T937T|HDAC9_ENST00000441542.2_Silent_p.T940T	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	937	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	GTCATTTGACGAAGCAATTGA	0.388000													15	101					0	0	0.006122	0	0
PHACTR3	116154	broad.mit.edu	37	20	58381144	58381144	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr20:58381144G>A	ENST00000371015.1	+	8	1690	c.1223G>A	c.(1222-1224)aGg>aAg	p.R408K	PHACTR3_ENST00000395636.2_Missense_Mutation_p.R367K|PHACTR3_ENST00000395639.4_Missense_Mutation_p.R297K|PHACTR3_ENST00000541461.1_Missense_Mutation_p.R367K|PHACTR3_ENST00000361300.4_Missense_Mutation_p.R297K|PHACTR3_ENST00000359926.3_Missense_Mutation_p.R405K|PHACTR3_ENST00000355648.4_Missense_Mutation_p.R367K	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	408						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GTGAAGCTAAGGAACCGGCCA	0.522000													26	124					0	0	0.004656	0	0
HAL	3034	broad.mit.edu	37	12	96380882	96380882	+	Silent	SNP	A	A	C			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr12:96380882A>C	ENST00000261208.3	-	12	1382	c.1014T>G	c.(1012-1014)ctT>ctG	p.L338L	HAL_ENST00000541929.1_Silent_p.L130L|HAL_ENST00000538703.1_Silent_p.L338L	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	338					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	TCAGCACCTCAAGGGTCAGGG	0.557000													20	82					0	0	0.008871	0	0
NGF	4803	broad.mit.edu	37	1	115829023	115829023	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:115829023C>T	ENST00000369512.2	-	3	562	c.394G>A	c.(394-396)Gaa>Aaa	p.E132K	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	132					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	ACCGAGAATTCGCCCCTGTGG	0.567000													6	42					0	0	0.001168	0	0
NAT2	10	broad.mit.edu	37	8	18258334	18258334	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr8:18258334C>T	ENST00000286479.3	+	2	928	c.821C>T	c.(820-822)tCc>tTc	p.S274F	NAT2_ENST00000520116.1_Missense_Mutation_p.S144F	NM_000015.2	NP_000006.2	P11245	ARY2_HUMAN	N-acetyltransferase 2 (arylamine N-acetyltransferase)	274					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(2)	12				Colorectal(111;0.0531)|COAD - Colon adenocarcinoma(73;0.21)		TTTAAGATTTCCTTGGGGAGA	0.358000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				18	34					0	0	0.006122	0	0
MEP1A	4224	broad.mit.edu	37	6	46800999	46800999	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:46800999C>T	ENST00000230588.4	+	11	1342	c.1333C>T	c.(1333-1335)Ctt>Ttt	p.L445F		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	445	MATH.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			CTCCCAAGTCCTTGAGAACAC	0.498000													24	55					0	0	0.003954	0	0
NKD2	85409	broad.mit.edu	37	5	1034917	1034917	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:1034917C>T	ENST00000296849.5	+	7	702	c.473C>T	c.(472-474)tCg>tTg	p.S158L	NKD2_ENST00000274150.4_Missense_Mutation_p.S158L|NKD2_ENST00000537972.1_Missense_Mutation_p.S158L	NM_033120.2	NP_149111.1	Q969F2	NKD2_HUMAN	naked cuticle homolog 2 (Drosophila)	158	Interaction with DVL1, DVL2 and DVL3 (By similarity).|Targeting to the basolateral cell membrane.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(3)|large_intestine(1)|lung(8)|pancreas(1)	14	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			GTGGATGCCTCGGTCAACCAC	0.627000													14	41					0	0	0.004007	0	0
CBLN2	147381	broad.mit.edu	37	18	70209153	70209153	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr18:70209153G>A	ENST00000269503.4	-	3	1016	c.243C>T	c.(241-243)tcC>tcT	p.S81S	CBLN2_ENST00000585159.1_Silent_p.S81S|CBLN2_ENST00000583651.1_Intron|CBLN2_ENST00000581073.1_Intron|CBLN2_ENST00000584764.1_Intron	NM_182511.3	NP_872317.1	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	81						integral to membrane				endometrium(2)|lung(15)	17		Esophageal squamous(42;0.131)				AGATGCCTAGGGAGGAGGTGA	0.697000													6	27					0	0	0.001168	0	0
SQLE	6713	broad.mit.edu	37	8	126015510	126015510	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr8:126015510C>T	ENST00000265896.5	+	2	1282	c.384C>T	c.(382-384)atC>atT	p.I128I	SQLE_ENST00000523430.1_Silent_p.I33I	NM_003129.3	NP_003120.2	Q14534	ERG1_HUMAN	squalene epoxidase	128					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	AAGTTATCATCGTGGGAGCTG	0.448000													19	35					0	0	0.006122	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977358	29977358	+	RNA	SNP	T	T	C	rs146982767	by1000genomes	TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:29977358T>C	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							GATTTGTTCATGCCTTCCCTT	0.448000													6	24					0	0	0.001168	0	0
SZT2	23334	broad.mit.edu	37	1	43896716	43896716	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:43896716C>T	ENST00000562955.1	+	32	4700	c.4700C>T	c.(4699-4701)cCc>cTc	p.P1567L	SZT2_ENST00000372442.1_Missense_Mutation_p.P725L	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1624						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CTGACTTTGCCCCTGGAAGTG	0.622000													11	52					0	0	0.010729	0	0
MYH8	4626	broad.mit.edu	37	17	10305096	10305096	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr17:10305096C>T	ENST00000403437.2	-	23	2789	c.2695G>A	c.(2695-2697)Gat>Aat	p.D899N	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	899					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GCCAAGCTATCTGCTTCCTAT	0.368000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				22	86					0	0	0.014323	0	0
RB1	5925	broad.mit.edu	37	13	49033822	49033822	+	Splice_Site	SNP	A	A	C			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr13:49033822A>C	ENST00000267163.4	+	20	2098		c.e20-1			NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(10)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTATTCCCACAGTGTATCGGC	0.358000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			9	38					0	0	0.010729	0	0
FAT1	2195	broad.mit.edu	37	4	187560922	187560922	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr4:187560922G>A	ENST00000441802.2	-	4	3805	c.3596C>T	c.(3595-3597)aCg>aTg	p.T1199M		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1199	Cadherin 10.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CTTCCTTGACGTAGTTGTGAT	0.328000										HNSCC(5;0.00058)			13	33					0	0	0.002450	0	0
LAMA5	3911	broad.mit.edu	37	20	60902710	60902710	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr20:60902710G>A	ENST00000252999.3	-	37	4879	c.4813C>T	c.(4813-4815)Ccc>Tcc	p.P1605S		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1605	Laminin EGF-like 15.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCACATTTGGGGCCCTGCACG	0.632000													14	43					0	0	0.001855	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777808	18777808	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr9:18777808G>A	ENST00000380548.4	+	19	3920	c.3581G>A	c.(3580-3582)gGg>gAg	p.G1194E		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1194	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CTGGCCAGCGGGACACTGAGT	0.627000													10	36					0	0	0.006214	0	0
RB1	5925	broad.mit.edu	37	13	48923091	48923091	+	Splice_Site	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr13:48923091G>A	ENST00000267163.4	+	6	677		c.e6-1			NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTGTTTAATAGGATATCTACT	0.259000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			4	31					0	0	0.001984	0	0
VEGFC	7424	broad.mit.edu	37	4	177608419	177608419	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr4:177608419C>T	ENST00000280193.2	-	6	1482	c.1067G>A	c.(1066-1068)gGa>gAa	p.G356E	RP11-313E19.2_ENST00000509194.1_RNA|RP11-313E19.2_ENST00000504017.1_RNA	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	356	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GGCACATTTTCCAGGATTTAG	0.438000													19	104					0	0	0.008871	0	0
POTEH	23784	broad.mit.edu	37	22	16279248	16279248	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr22:16279248C>T	ENST00000343518.6	-	4	1026	c.975G>A	c.(973-975)gtG>gtA	p.V325V		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	325										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TTAAAAATTTCACCACTTGCT	0.328000													7	234					0	0	0.001984	0	0
STAG1	10274	broad.mit.edu	37	3	136240075	136240075	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr3:136240075C>T	ENST00000383202.2	-	7	912	c.656G>A	c.(655-657)aGg>aAg	p.R219K	STAG1_ENST00000434713.2_5'UTR|STAG1_ENST00000236698.5_Missense_Mutation_p.R219K|STAG1_ENST00000480733.1_Missense_Mutation_p.R219K	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	219					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						ACTTGTATGCCTAAAAGCTCT	0.348000													7	22					0	0	0.001984	0	0
BAI1	575	broad.mit.edu	37	8	143623501	143623501	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr8:143623501C>T	ENST00000517894.1	+	28	4800	c.3906C>T	c.(3904-3906)ttC>ttT	p.F1302F	BAI1_ENST00000323289.5_Silent_p.F1302F			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1302					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGCCCGACTTCCCCAACCACT	0.657000													26	36					0	0	0.004656	0	0
EMR2	30817	broad.mit.edu	37	19	14875264	14875264	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr19:14875264G>A	ENST00000315576.3	-	11	1516	c.1065C>T	c.(1063-1065)ttC>ttT	p.F355F	EMR2_ENST00000392965.3_Silent_p.F355F|EMR2_ENST00000601345.1_Silent_p.F355F|EMR2_ENST00000392967.2_Silent_p.F355F|EMR2_ENST00000392964.3_Silent_p.F94F|EMR2_ENST00000596991.2_Silent_p.F355F|EMR2_ENST00000595839.1_Silent_p.F213F|EMR2_ENST00000346057.1_Silent_p.F306F|EMR2_ENST00000353005.1_Silent_p.F213F|EMR2_ENST00000594294.1_Silent_p.F306F|EMR2_ENST00000594076.1_Silent_p.F262F|EMR2_ENST00000353876.1_Silent_p.F262F	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	355					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						CAGGATAACTGAAGTTCAACA	0.567000													5	35					0	0	0.000602	0	0
CCNB3	85417	broad.mit.edu	37	X	50051656	50051656	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chrX:50051656G>A	ENST00000376042.1	+	6	785	c.487G>A	c.(487-489)Gaa>Aaa	p.E163K	CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000276014.7_Missense_Mutation_p.E163K|CCNB3_ENST00000348603.2_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	163					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TTTAAAGGAGGAACCCACTAT	0.413000													9	32					0	0	0.004482	0	0
PARP14	54625	broad.mit.edu	37	3	122422609	122422609	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr3:122422609C>T	ENST00000474629.2	+	7	3368	c.3102C>T	c.(3100-3102)tcC>tcT	p.S1034S		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1034	Macro 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		TTGTCAACTCCGTTCCCTTGG	0.418000													5	26					0	0	0.000602	0	0
ACAN	176	broad.mit.edu	37	15	89400694	89400694	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr15:89400694C>T	ENST00000439576.2	+	12	5252	c.4878C>T	c.(4876-4878)ccC>ccT	p.P1626P	ACAN_ENST00000561243.1_Silent_p.P1626P|ACAN_ENST00000559004.1_Silent_p.P1626P|ACAN_ENST00000352105.7_Silent_p.P1626P	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1626					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GTGGTCTTCCCTCTGGATTTA	0.522000													25	118					0	0	0.003954	0	0
CORIN	10699	broad.mit.edu	37	4	47597789	47597789	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr4:47597789G>A	ENST00000273857.4	-	22	3077	c.3078C>T	c.(3076-3078)ttC>ttT	p.F1026F	CORIN_ENST00000508498.1_Silent_p.F887F|CORIN_ENST00000505909.1_Silent_p.F989F|CORIN_ENST00000502252.1_Silent_p.F959F	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	1026	Peptidase S1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						TCCATTCGACGAAATATGACA	0.418000													10	52					0	0	0.010729	0	0
HTR3B	9177	broad.mit.edu	37	11	113802492	113802492	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr11:113802492G>A	ENST00000260191.2	+	4	528	c.271G>A	c.(271-273)Gaa>Aaa	p.E91K	HTR3B_ENST00000537778.1_Missense_Mutation_p.E80K	NM_006028.4	NP_006019.1	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	91					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(11)	20		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		CTGGAATGATGAATTTTTATC	0.388000													6	20					0	0	0.001984	0	0
ACACB	32	broad.mit.edu	37	12	109660343	109660343	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr12:109660343C>T	ENST00000338432.7	+	25	3715	c.3596C>T	c.(3595-3597)tCg>tTg	p.S1199L	ACACB_ENST00000377854.5_Missense_Mutation_p.S1129L|ACACB_ENST00000377848.3_Missense_Mutation_p.S1199L			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1199					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CCTTCCCTGTCGGACGAGCTG	0.572000													15	60					0	0	0.002450	0	0
IGLV3-19	28797	broad.mit.edu	37	22	23063523	23063523	+	RNA	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr22:23063523C>T	ENST00000390309.2	+	0	270																											TCAGGGATCCCAGACCGATTC	0.542000													5	22					0	0	0.001168	0	0
CUL7	9820	broad.mit.edu	37	6	43013793	43013793	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:43013793A>T	ENST00000535468.1	-	13	3035	c.2949T>A	c.(2947-2949)agT>agA	p.S983R	CUL7_ENST00000478630.1_5'UTR|CUL7_ENST00000265348.3_Missense_Mutation_p.S899R	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	899	DOC.				interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCGGCATGTAACTCGAGTCCT	0.577000													8	39					0	0	0.006214	0	0
MAP3K6	9064	broad.mit.edu	37	1	27687213	27687213	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:27687213G>A	ENST00000374040.3	-	14	2273	c.2013C>T	c.(2011-2013)atC>atT	p.I671I	MAP3K6_ENST00000357582.2_Silent_p.I679I|MAP3K6_ENST00000493901.1_Silent_p.I679I			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	679	Protein kinase.				activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CCCGCTCCGGGATCTCCTTGA	0.736000													7	36					0	0	0.001984	0	0
RFX6	222546	broad.mit.edu	37	6	117252545	117252545	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:117252545G>A	ENST00000332958.2	+	19	2679	c.2663G>A	c.(2662-2664)gGa>gAa	p.G888E		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	888					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TGTATGTATGGAACTTCCAAC	0.408000													25	45					0	0	0.006320	0	0
UGGT2	55757	broad.mit.edu	37	13	96536834	96536834	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr13:96536834G>A	ENST00000376747.3	-	27	3209	c.3139C>T	c.(3139-3141)Ctc>Ttc	p.L1047F		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	1047					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						AGGATTAGGAGGGGTGATTCA	0.413000													3	33					0	0	0.004672	0	0
RAG2	5897	broad.mit.edu	37	11	36614827	36614827	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr11:36614827C>T	ENST00000311485.3	-	2	1053	c.892G>A	c.(892-894)Gaa>Aaa	p.E298K		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	298					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				TCACGAATTTCTATCTTGTTG	0.383000									Familial Hemophagocytic Lymphohistiocytosis				13	63					0	0	0.001855	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179306081	179306081	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:179306081C>T	ENST00000356834.3	-	9	1570	c.1533G>A	c.(1531-1533)gaG>gaA	p.E511E	TBC1D9B_ENST00000355235.3_Silent_p.E511E	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	511	Rab-GAP TBC.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCGGAGGCTCTCAGGGATAC	0.632000													4	54					0	0	0.009096	0	0
NANOG	79923	broad.mit.edu	37	12	7947129	7947129	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr12:7947129G>A	ENST00000229307.4	+	3	710	c.491G>A	c.(490-492)gGt>gAt	p.G164D	NANOG_ENST00000526286.1_Missense_Mutation_p.G164D	NM_024865.2	NP_079141.2	Q9H9S0	NANOG_HUMAN	Nanog homeobox	164					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14				Kidney(36;0.0872)		AATAGCAATGGTGTGACGCAG	0.423000													5	9					0	0	0.000602	0	0
RSPO3	84870	broad.mit.edu	37	6	127469798	127469798	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:127469798C>T	ENST00000356698.4	+	2	692	c.103C>T	c.(103-105)Cct>Tct	p.P35S	RSPO3_ENST00000485757.1_3'UTR|RSPO3_ENST00000368317.3_Missense_Mutation_p.P35S	NM_032784.3	NP_116173.2	Q9BXY4	RSPO3_HUMAN	R-spondin 3	35						extracellular region	heparin binding		PTPRK/RSPO3(10)	breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17				GBM - Glioblastoma multiforme(226;0.0555)		CACAGTGCATCCTAACGTTAG	0.383000													18	34					0	0	0.006122	0	0
CHD4	1108	broad.mit.edu	37	12	6705279	6705279	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr12:6705279G>A	ENST00000309577.6	-	13	2080	c.1917C>T	c.(1915-1917)caC>caT	p.H639H	CHD4_ENST00000544484.1_Silent_p.H636H|CHD4_ENST00000544040.1_Silent_p.H632H|CHD4_ENST00000357008.2_Silent_p.H639H			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	639	Chromo 2.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TGATCAAGTAGTGGACGTGGC	0.507000													9	38					0	0	0.006214	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935417	151935417	+	Silent	SNP	G	G	A	rs149076914		TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chrX:151935417G>A	ENST00000393902.3	-	3	1317	c.750C>T	c.(748-750)ttC>ttT	p.F250F	MAGEA3_ENST00000370278.3_Silent_p.F250F			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	250	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCCTGCACGAAATGTTGGG	0.537000													37	134					0	0	0.004289	0	0
GTF2A2	2958	broad.mit.edu	37	15	59942972	59942972	+	Splice_Site	SNP	A	A	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr15:59942972A>T	ENST00000396060.2	-	3	254	c.72_splice	c.e3-1	p.S25_splice	GTF2A2_ENST00000396063.1_Splice_Site_p.S25_splice|GTF2A2_ENST00000396061.1_Splice_Site_p.S25_splice|GTF2A2_ENST00000267869.4_Intron|GTF2A2_ENST00000484743.1_Intron|AC092755.4_ENST00000441746.1_RNA|GTF2A2_ENST00000396064.3_Splice_Site_p.S25_splice	NM_004492.2	NP_004483.1	P52657	T2AG_HUMAN	general transcription factor IIA, 2, 12kDa	25					interspecies interaction between organisms|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIA complex	protein heterodimerization activity|protein homodimerization activity|TBP-class protein binding|transcription coactivator activity			central_nervous_system(2)|kidney(2)|lung(1)	5						ATCTGTTGAGACTGAGAAAAG	0.358000													6	38					0	0	0.001168	0	0
GPR6	2830	broad.mit.edu	37	6	110301378	110301378	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:110301378C>T	ENST00000414000.2	+	3	1347	c.1108C>T	c.(1108-1110)Cgt>Tgt	p.R370C	GPR6_ENST00000275169.3_Missense_Mutation_p.R355C			P46095	GPR6_HUMAN	G protein-coupled receptor 6	355						integral to plasma membrane		p.R355C(1)		breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		AGTGCCCTTTCGTTCCAGGTC	0.592000													49	99					0	0	0.014410	0	0
DNAH12	201625	broad.mit.edu	37	3	57488087	57488087	+	Silent	SNP	C	C	T	rs141849816	byFrequency	TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr3:57488087C>T	ENST00000351747.2	-	10	1386	c.1206G>A	c.(1204-1206)cgG>cgA	p.R402R	DNAH12_ENST00000311202.6_Silent_p.R402R|DNAH12_ENST00000389536.4_Silent_p.R402R	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	402	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						CTTCTAAGTTCCGATGTACTG	0.393000													4	49					0	0	0.009096	0	0
SH2D3A	10045	broad.mit.edu	37	19	6760692	6760692	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr19:6760692C>T	ENST00000245908.6	-	3	645	c.376G>A	c.(376-378)Gag>Aag	p.E126K	SH2D3A_ENST00000599563.1_5'UTR|SH2D3A_ENST00000437152.3_Intron	NM_005490.2	NP_005481.2	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	126					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|urinary_tract(1)	24						AGGGTGTCCTCGCTAAAGCTG	0.602000													13	42					0	0	0.001855	0	0
CXorf58	254158	broad.mit.edu	37	X	23953461	23953461	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chrX:23953461G>A	ENST00000379211.3	+	7	1253	c.704G>A	c.(703-705)cGa>cAa	p.R235Q		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	235										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						AACCGTCTACGAAATGAAATG	0.378000													7	54					0	0	0.001984	0	0
PER1	5187	broad.mit.edu	37	17	8053142	8053142	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr17:8053142G>A	ENST00000317276.4	-	5	819	c.582C>T	c.(580-582)tcC>tcT	p.S194S	PER1_ENST00000354903.5_Silent_p.S178S|PER1_ENST00000581082.1_Silent_p.S194S	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	194					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						ACATGTCCATGGAGCAAGGCT	0.592000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					44	207					0	0	0.009718	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588458	20588458	+	RNA	SNP	G	G	C	rs2291971	by1000genomes	TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr15:20588458G>C	ENST00000428453.1	-	0	4292																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TGCTGGCCATGACTGCAGTGC	0.458000													9	27					0	0	0.004482	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40295428	40295428	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr15:40295428C>T	ENST00000263791.5	+	23	3313	c.3270C>T	c.(3268-3270)ccC>ccT	p.P1090P	EIF2AK4_ENST00000559311.1_3'UTR|EIF2AK4_ENST00000382727.2_Silent_p.P1062P	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1090	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TACTGCTTCCCCGAAACAGAC	0.468000													12	38					0	0	0.013537	0	0
GPR123	84435	broad.mit.edu	37	10	134942150	134942150	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr10:134942150G>A	ENST00000607359.1	+	16	2975	c.2975G>A	c.(2974-2976)gGg>gAg	p.G992E	GPR123_ENST00000392607.3_Missense_Mutation_p.G273E|GPR123_ENST00000392606.2_Missense_Mutation_p.G176E			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	273						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		TGGGCCTTCGGGGCGCTGGCG	0.672000													4	15					0	0	0.009096	0	0
NWD1	284434	broad.mit.edu	37	19	16860837	16860837	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr19:16860837G>A	ENST00000524140.2	+	6	1802	c.1384G>A	c.(1384-1386)Gtg>Atg	p.V462M	NWD1_ENST00000552788.1_Missense_Mutation_p.V462M|NWD1_ENST00000549814.1_Missense_Mutation_p.V462M|NWD1_ENST00000523826.1_Missense_Mutation_p.V256M|NWD1_ENST00000379808.3_Missense_Mutation_p.V462M|NWD1_ENST00000339803.6_Missense_Mutation_p.V327M	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	462	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CCCCCCGAGGGTGCACCTCAT	0.642000													14	108					0	0	0.003163	0	0
C22orf43	51233	broad.mit.edu	37	22	23956351	23956351	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr22:23956351C>T	ENST00000317749.5	-	9	889	c.592G>A	c.(592-594)Gaa>Aaa	p.E198K		NM_016449.3	NP_057533.2	Q6PGQ1	CV043_HUMAN	chromosome 22 open reading frame 43	198	Asp-rich.									endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						TCTTCTTCTTCATCTTTGTGT	0.403000													10	23					0	0	0.013537	0	0
ARMC12	221481	broad.mit.edu	37	6	35706273	35706273	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:35706273G>A	ENST00000373866.3	+	3	444	c.422G>A	c.(421-423)aGa>aAa	p.R141K	ARMC12_ENST00000373869.3_Missense_Mutation_p.R141K|ARMC12_ENST00000288065.2_Missense_Mutation_p.R168K			Q5T9G4	CF081_HUMAN	armadillo repeat containing 12	141							binding										TCTGGCATCAGAAAATTCAGG	0.463000													11	49					0	0	0.002450	0	0
SALL1	6299	broad.mit.edu	37	16	51174856	51174856	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr16:51174856C>T	ENST00000440970.1	-	2	1417	c.986G>A	c.(985-987)aGa>aAa	p.R329K	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.R426K|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	426					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTTGCTTTTTCTTTGCTGGGC	0.507000													14	71					0	0	0.001855	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482555	140482555	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:140482555C>T	ENST00000231130.2	+	1	2322	c.2322C>T	c.(2320-2322)ttC>ttT	p.F774F		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		774					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCCAACTTCGTTGCTCAGG	0.507000													14	55					0	0	0.014323	0	0
SNX30	401548	broad.mit.edu	37	9	115593151	115593151	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr9:115593151C>T	ENST00000374232.3	+	4	770	c.606C>T	c.(604-606)ttC>ttT	p.F202F		NM_001012994.1	NP_001013012.1	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	202	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding			large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						TTAATATTTTCCTTACTGCTA	0.393000													6	30					0	0	0.001168	0	0
CFTR	1080	broad.mit.edu	37	7	117175352	117175352	+	Silent	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr7:117175352C>T	ENST00000003084.6	+	6	762	c.630C>T	c.(628-630)ctC>ctT	p.L210L	CFTR_ENST00000454343.1_Silent_p.L210L	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	210	ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AAGTGGCACTCCTCATGGGGC	0.498000									Cystic Fibrosis				25	100					0	0	0.003954	0	0
OR2M3	127062	broad.mit.edu	37	1	248366863	248366863	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:248366863C>T	ENST00000456743.1	+	1	532	c.494C>T	c.(493-495)tCc>tTc	p.S165F		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCAACATTTTCCTTCTCCTAC	0.433000													86	113					0	0	0.014410	0	0
HSPA5	3309	broad.mit.edu	37	9	128002471	128002471	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr9:128002471C>T	ENST00000324460.6	-	3	675	c.472G>A	c.(472-474)Gag>Aag	p.E158K		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	158					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	AAATAAGCCTCAGCGGTTTCT	0.358000										Prostate(1;0.17)			4	20					0	0	0.009096	0	0
TENM1	10178	broad.mit.edu	37	X	123871004	123871004	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chrX:123871004G>A	ENST00000422452.2	-	4	642	c.579C>T	c.(577-579)ctC>ctT	p.L193L	TENM1_ENST00000371130.3_Silent_p.L193L	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GTGGCGGTGGGAGGGGTCTGA	0.562000													9	52					0	0	0.004482	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356375	40356375	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr4:40356375G>A	ENST00000310169.2	+	5	1417	c.1278G>A	c.(1276-1278)agG>agA	p.R426R		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	426					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	TGCTGACGAGGAATATTGAGT	0.498000													3	32					0	0	0.004672	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236087	140236087	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr5:140236087C>T	ENST00000307360.5	+	1	454	c.454C>T	c.(454-456)Cca>Tca	p.P152S	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.P152S|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTCGATTTCCACTAGAAGG	0.428000													20	89					0	0	0.012319	0	0
TLE1	7088	broad.mit.edu	37	9	84231585	84231585	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr9:84231585G>A	ENST00000376499.3	-	10	1805	c.741C>T	c.(739-741)aaC>aaT	p.N247N	TLE1_ENST00000376472.1_5'UTR|TLE1_ENST00000464999.1_5'UTR	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	247	CCN domain.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						CCACAACTAAGTTGTCATCGC	0.328000													13	24					0	0	0.001855	0	0
SULT2B1	6820	broad.mit.edu	37	19	49090527	49090527	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr19:49090527G>A	ENST00000323090.4	+	2	586	c.211G>A	c.(211-213)Gaa>Aaa	p.E71K	SULT2B1_ENST00000201586.2_Missense_Mutation_p.E86K	NM_004605.2	NP_004596.2	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	86					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	11		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		AATCCTGAAGGAAGGGGATCC	0.572000													9	51					0	0	0.006214	0	0
ZFHX3	463	broad.mit.edu	37	16	72993635	72993635	+	Missense_Mutation	SNP	G	G	A	rs140908169		TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr16:72993635G>A	ENST00000268489.5	-	2	1082	c.410C>T	c.(409-411)cCg>cTg	p.P137L	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	137					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GGAGCCGTCCGGCTGGTAGAC	0.692000													16	47					0	0	0.006122	0	0
PISD	23761	broad.mit.edu	37	22	32019697	32019697	+	Silent	SNP	G	G	A			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr22:32019697G>A	ENST00000382151.2	-	3	611	c.192C>T	c.(190-192)agC>agT	p.S64S	PISD_ENST00000397500.1_Silent_p.S64S|PISD_ENST00000336566.4_Intron|PISD_ENST00000439502.2_Intron|PISD_ENST00000266095.5_Silent_p.S64S|PISD_ENST00000478893.1_5'UTR			Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	0					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(3)|endometrium(2)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12					Phosphatidylserine(DB00144)	ATCCCACCCGGCTGAGCGGTC	0.662000													12	48					0	0	0.013537	0	0
SZT2	23334	broad.mit.edu	37	1	43902868	43902868	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr1:43902868delC	ENST00000562955.1	+	42	5890	c.5890delC	c.(5890-5892)ccfs	p.P1964fs	SZT2_ENST00000372442.1_Frame_Shift_Del_p.P1122fs	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2021						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GAGCTGTGCGCCCCGTGGGTA	0.562													15	107	---	---	---	---					
LEMD2	221496	broad.mit.edu	37	6	33756881	33756882	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr6:33756881_33756882delAC	ENST00000293760.5	-	1	31_32	c.12_13delGT	c.(10-15)ctcgfs	p.LS4fs		NM_181336.3	NP_851853.1	Q8NC56	LEMD2_HUMAN	LEM domain containing 2	4	LEM.					integral to nuclear inner membrane				central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(2)|pancreas(1)	9						TCCAGGTCCGACAGGCCGGCCA	0.762													24	44	---	---	---	---					
PTEN	5728	broad.mit.edu	37	10	89653858	89653859	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D3-A1Q7-06A-11D-A19A-08	TCGA-D3-A1Q7-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1a8ab712-7bb1-4ec4-8f15-0779ae8f782e	c59cf762-f216-44f6-b633-c66edb546435	g.chr10:89653858_89653859insC	ENST00000371953.3	+	2	1513_1514	c.156_157insC	c.(154-159)gatagtfs	p.S53fs		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	53	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(8)|p.D52del(2)|p.Y27fs*1(2)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		ATATTGATGATGTAGTAAGGTA	0.297		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			5	4	---	---	---	---