Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TPK1	27010	broad.mit.edu	37	7	144288534	144288534	+	Silent	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr7:144288534C>T	uc003weq.3	-	6	586	c.483G>A	c.(481-483)ctG>ctA	p.L161L	TPK1_uc003weo.3_Intron|TPK1_uc003wep.3_Non-coding_Transcript|TPK1_uc003wer.3_Intron|TPK1_uc003wes.3_Non-coding_Transcript	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	Homo sapiens thiamin pyrophosphokinase 1 (TPK1), transcript variant 1, mRNA.	161					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			large_intestine(3)|lung(12)|ovary(2)|urinary_tract(2)	19					Thiamine(DB00152)	GCAGGTAGATCAGCGATTCCT	0.423000														144			118		0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54849692	54849692	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:54849692G>A	uc002qfj.3	-	2	387	c.330C>T	c.(328-330)agC>agT	p.S110S	LILRA4_uc002qfi.3_Silent_p.S44S	NM_012276	NP_036408	P59901	LIRA4_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 (LILRA4), mRNA.	110	Ig-like C2-type 1.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		CCAGGGGGTCGCTGGGCTCTG	0.607000														92			38		0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688844	60688844	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:60688844G>A	uc002sae.1	-	3	1431	c.1203C>T	c.(1201-1203)ggC>ggT	p.G401G	BCL11A_uc002sab.3_Silent_p.G401G|BCL11A_uc002sac.3_Intron|BCL11A_uc010ypi.2_Silent_p.G70G|BCL11A_uc010ypj.2_Silent_p.G367G|BCL11A_uc002sad.1_Silent_p.G249G|BCL11A_uc002saf.1_Silent_p.G367G	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	Homo sapiens B-cell CLL/lymphoma 11A (zinc finger protein) (BCL11A), transcript variant 1, mRNA.	401					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			AGGGCTTCTCGCCCGTGTGGC	0.607000			T	IGH@	B-CLL									135			144		0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83346082	83346082	+	Missense_Mutation	SNP	G	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:83346082G>C	uc010uoi.2	-	12	1609	c.1432C>G	c.(1432-1434)Cca>Gca	p.P478A	AP3B2_uc010uoh.2_Missense_Mutation_p.P478A|AP3B2_uc010uoj.2_Missense_Mutation_p.P446A|AP3B2_uc010uog.2_Missense_Mutation_p.P114A	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	Homo sapiens adaptor-related protein complex 3, beta 2 subunit (AP3B2), mRNA.	478					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	COPI-coated vesicle|clathrin coated vesicle membrane|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			TGTTGTGCTGGCTGCATCTGT	0.478000														40			6		0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933112	43933112	+	Silent	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr20:43933112C>T	uc002xnn.2	-	2	586	c.399G>A	c.(397-399)ccG>ccA	p.P133P	MATN4_uc002xnp.2_Silent_p.P133P|MATN4_uc002xno.2_Silent_p.P133P|MATN4_uc010zwr.1_Silent_p.P81P|MATN4_uc002xnr.1_Silent_p.P133P|RBPJL_uc002xns.3_5'Flank|RBPJL_uc002xnt.3_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	Homo sapiens matrilin 4 (MATN4), transcript variant 1, mRNA.	133	VWFA 1.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				GCTCCTCTGGCGGTCGCGCGC	0.716000														15			9		0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430948	37430948	+	Missense_Mutation	SNP	C	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:37430948C>G	uc021ppc.1	+	6	1054	c.955C>G	c.(955-957)Cca>Gca	p.P319A	ANKRD30A_uc001iza.1_Missense_Mutation_p.P319A	NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	Homo sapiens ankyrin repeat domain 30A (ANKRD30A), mRNA.	375						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATTTACGTGGCCAGCAAAAGG	0.423000														154			8		0	0	1	0	0
FBXO38	81545	broad.mit.edu	37	5	147820746	147820746	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:147820746C>T	uc003lpf.1	+	20	3454	c.3334C>T	c.(3334-3336)Cga>Tga	p.R1112*	FBXO38_uc003lpg.1_Nonsense_Mutation_p.R1037*|FBXO38_uc003lph.2_Nonsense_Mutation_p.R867*	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	Homo sapiens F-box protein 38 (FBXO38), transcript variant 2, mRNA.	1112						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGTCATTACGAGCTGCAGA	0.438000														124			52		0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76528954	76528954	+	Missense_Mutation	SNP	G	A	A	rs138136389	byFrequency	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr16:76528954G>A	uc002fex.1	+	12	2376	c.2237G>A	c.(2236-2238)cGg>cAg	p.R746Q	CNTNAP4_uc002feu.1_Missense_Mutation_p.R742Q|CNTNAP4_uc002fev.1_Missense_Mutation_p.R607Q|CNTNAP4_uc010chb.1_Missense_Mutation_p.R670Q|CNTNAP4_uc002few.2_Missense_Mutation_p.R718Q	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	Homo sapiens contactin associated protein-like 4 (CNTNAP4), transcript variant 1, mRNA.	743	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GATGCTGACCGGAATGAATGG	0.358000														88			50		0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150527966	150527966	+	Silent	SNP	T	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:150527966T>C	uc009wlw.3	+	7	1523	c.1365T>C	c.(1363-1365)cgT>cgC	p.R455R	ADAMTSL4_uc001euw.3_Silent_p.R432R|ADAMTSL4_uc001eux.3_Silent_p.R432R|ADAMTSL4_uc010pcg.2_Silent_p.R455R|ADAMTSL4_uc009wlx.3_5'Flank	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	Homo sapiens ADAMTS-like 4 (ADAMTSL4), transcript variant 1, mRNA.	432					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding	p.R455H(1)		breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TCTATGTCCGTCACACTGAAA	0.607000														87			14		0	0	1	0	0
SLC9A7	84679	broad.mit.edu	37	X	46466517	46466517	+	Missense_Mutation	SNP	G	A	A	rs146808441		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chrX:46466517G>A	uc004dgu.1	-	16	2056	c.2048C>T	c.(2047-2049)aCg>aTg	p.T683M		NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 7 (SLC9A7), mRNA.	683					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						CTCCAGACTCGTGGAGGCGGT	0.602000														2			38		0	0	1	0	0
LGALS12	85329	broad.mit.edu	37	11	63278567	63278567	+	Missense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr11:63278567G>A	uc001nxc.2	+	5	958	c.617G>A	c.(616-618)aGc>aAc	p.S206N	LGALS12_uc001nxa.2_Missense_Mutation_p.S205N|LGALS12_uc001nxb.2_Intron|LGALS12_uc001nxd.2_Missense_Mutation_p.S144N|LGALS12_uc001nxe.2_Intron|LGALS12_uc009yot.2_Missense_Mutation_p.S165N	NM_001142535	NP_001136007	Q96DT0	LEG12_HUMAN	Homo sapiens lectin, galactoside-binding, soluble, 12 (LGALS12), transcript variant 1, mRNA.	205					apoptosis|induction of apoptosis by intracellular signals	nucleus	lactose binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	16						CTGCTGATGAGCCCCAGGCTG	0.552000														79			7		0	0	1	0	0
LOC650623	650623	broad.mit.edu	37	10	81443821	81443821	+	RNA	SNP	C	G	G	rs150975459	by1000genomes	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:81443821C>G	uc010qlu.2	+	0		c.1091C>G								Homo sapiens BEN domain containing 3 pseudogene (LOC650623), non-coding RNA.																		GCAGCACCATCGCCTCAGACC	0.612000														43			6		0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21217066	21217066	+	Missense_Mutation	SNP	A	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:21217066A>T	uc003zor.1	-	0	245	c.239T>A	c.(238-240)tTc>tAc	p.F80Y	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	Homo sapiens interferon, alpha 16 (IFNA16), mRNA.	80					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		CATCTCATGGAAGGCAGAGAT	0.468000														14			115		0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24839702	24839702	+	Silent	SNP	A	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:24839702A>G	uc001wpc.3	+	1	1419	c.1098A>G	c.(1096-1098)ggA>ggG	p.G366G	NFATC4_uc010alr.3_Silent_p.G429G|NFATC4_uc010tok.2_Silent_p.G429G|NFATC4_uc010tol.2_Silent_p.G429G|NFATC4_uc010als.2_Silent_p.G379G|NFATC4_uc010too.2_Silent_p.G379G|NFATC4_uc010tom.2_Silent_p.G379G|NFATC4_uc010ton.2_Silent_p.G379G|NFATC4_uc010toq.2_Silent_p.G398G|NFATC4_uc010alt.3_Silent_p.G398G|NFATC4_uc010top.2_Silent_p.G398G|NFATC4_uc010alu.3_Intron|NFATC4_uc010tor.2_Silent_p.G366G|NFATC4_uc010tos.2_Silent_p.G296G|NFATC4_uc010tot.2_Silent_p.G354G|NFATC4_uc010tou.2_Silent_p.G296G|NFATC4_uc010tov.2_Silent_p.G354G|NFATC4_uc010tow.2_Silent_p.G296G|NFATC4_uc010alv.3_Silent_p.G354G|NFATC4_uc010tox.2_Silent_p.G296G|NFATC4_uc001wpd.3_5'Flank|NFATC4_uc010toy.2_5'Flank|NFATC4_uc010toz.2_5'Flank	NM_004554	NP_001185895	Q14934	NFAC4_HUMAN	Homo sapiens nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (NFATC4), transcript variant 2, mRNA.	366					cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CTCCTCCAGGAGGTTCCCGGA	0.637000														49			26		0	0	1	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396134	38396134	+	Missense_Mutation	SNP	C	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:38396134C>A	uc022bgy.1	+	0	389	c.389C>A	c.(388-390)cCt>cAt	p.P130H	ALDH1B1_uc004aay.3_Missense_Mutation_p.P130H	NM_000692	NP_000683	P30837	AL1B1_HUMAN	Homo sapiens aldehyde dehydrogenase 1 family, member B1 (ALDH1B1), nuclear gene encoding mitochondrial protein, mRNA.	130					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity	p.K129N(1)		NS(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(1)|stomach(2)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	AATGGGAAGCCTTTCCAAGAG	0.577000														262			80		4.82855e-46	5.64376e-46	1	1	0
FBXL7	23194	broad.mit.edu	37	5	15936915	15936915	+	Missense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:15936915G>A	uc003jfn.1	+	3	1577	c.1096G>A	c.(1096-1098)Gtg>Atg	p.V366M		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	Homo sapiens F-box and leucine-rich repeat protein 7 (FBXL7), mRNA.	366					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GGTCACCGACGTGGGCATCCG	0.672000														34			4		0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55088554	55088554	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:55088554T>A	uc003jqg.4	+	16	1487	c.1388T>A	c.(1387-1389)tTa>tAa	p.L463*	DDX4_uc010ivz.3_Nonsense_Mutation_p.L443*|DDX4_uc003jqh.4_Nonsense_Mutation_p.L429*|DDX4_uc003jqj.3_Nonsense_Mutation_p.L314*	NM_024415	NP_077726	Q9NQI0	DDX4_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 (DDX4), transcript variant 1, mRNA.	463	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	24		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				ATGAAGAAGTTAATTTCTTGC	0.363000														215			21		0	0	1	0	0
RANBP9	10048	broad.mit.edu	37	6	13711709	13711709	+	Missense_Mutation	SNP	G	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr6:13711709G>T	uc003nbb.3	-	0	88	c.29C>A	c.(28-30)cCg>cAg	p.P10Q		NM_005493	NP_005484	Q96S59	RANB9_HUMAN	Homo sapiens RAN binding protein 9 (RANBP9), mRNA.	10	Poly-Pro.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ctgctgctgcggcggcggcgg	0.761000														23			4		0.150653	0.157661	1	1	0
DNA2	1763	broad.mit.edu	37	10	70182143	70182143	+	Missense_Mutation	SNP	G	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:70182143G>T	uc021pru.1	-	16	2794	c.2794C>A	c.(2794-2796)Ctg>Atg	p.L932M	DNA2_uc021prt.1_Missense_Mutation_p.L932M|DNA2_uc021prv.1_Missense_Mutation_p.L103M|DNA2_uc001jog.2_Intron|DNA2_uc001joh.2_Non-coding_Transcript	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	Homo sapiens DNA replication helicase 2 homolog (yeast) (DNA2), mRNA.	846					DNA replication, removal of RNA primer|S phase of mitotic cell cycle|base-excision repair|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						CCACACTCCAGCTTGCCCTCA	0.363000														62			3		1	1	1	1	0
LCP1	3936	broad.mit.edu	37	13	46721149	46721149	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr13:46721149G>A	uc001vaz.4	-	9	1194	c.1068C>T	c.(1066-1068)gtC>gtT	p.V356V	LCP1_uc001vay.4_5'Flank|LCP1_uc001vba.4_Silent_p.V356V	NM_002298	NP_002289	P13796	PLSL_HUMAN	Homo sapiens lymphocyte cytosolic protein 1 (L-plastin) (LCP1), mRNA.	356	Actin-binding 1.|CH 2.				T cell activation involved in immune response|regulation of intracellular protein transport	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		GGTTCCCTCGGACAACATCTG	0.547000			T	BCL6	NHL									63			69		0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24537572	24537572	+	Missense_Mutation	SNP	A	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:24537572A>T	uc003jgr.2	-	2	949	c.443T>A	c.(442-444)aTc>aAc	p.I148N	CDH10_uc011cnu.2_Non-coding_Transcript	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	Homo sapiens cadherin 10, type 2 (T2-cadherin) (CDH10), mRNA.	148	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATGAATTTTGATCACAAACTC	0.418000										HNSCC(23;0.051)				174			61		0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728170	20728170	+	Missense_Mutation	SNP	G	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:20728170G>C	uc002npa.3	-	3	1019	c.839C>G	c.(838-840)aCt>aGt	p.T280S		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	Homo sapiens zinc finger protein 737 (ZNF737), mRNA.	280					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TTTCTCTCCAGTATGAATTAT	0.413000														76			3		0	0	1	0	0
SLC16A12	387700	broad.mit.edu	37	10	91198576	91198576	+	Silent	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:91198576C>T	uc001kgm.3	-	5	1114	c.813G>A	c.(811-813)ttG>ttA	p.L271L	SLC16A12_uc001kgl.3_5'Flank	NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	Homo sapiens solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (SLC16A12), mRNA.	241						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						ACTCTTGCTGCAAACAGCAAC	0.448000														9			36		0	0	1	0	0
ARRDC2	27106	broad.mit.edu	37	19	18120412	18120412	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:18120412G>A	uc002nhv.3	+	3	644	c.501G>A	c.(499-501)gcG>gcA	p.A167A	ARRDC2_uc002nhu.3_Silent_p.A162A	NM_015683	NP_056498	Q8TBH0	ARRD2_HUMAN	Homo sapiens arrestin domain containing 2 (ARRDC2), transcript variant 1, mRNA.	167								p.K167N(1)		endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)	12						CACCTCAAGCGGGGGCTCGGG	0.587000														164			47		0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163059576	163059576	+	Missense_Mutation	SNP	T	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:163059576T>C	uc002ucd.3	-	12	1335	c.1127A>G	c.(1126-1128)cAt>cGt	p.H376R	FAP_uc010zct.2_Missense_Mutation_p.H351R	NM_004460	NP_004451	Q12884	SEPR_HUMAN	Homo sapiens fibroblast activation protein, alpha (FAP), mRNA.	376					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity	p.H376H(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						ATAGTGAATATGTTTGTAGCC	0.363000														34			24		0	0	1	0	0
AATF	26574	broad.mit.edu	37	17	35348139	35348139	+	Missense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:35348139G>A	uc002hni.3	+	7	1632	c.1381G>A	c.(1381-1383)Gat>Aat	p.D461N		NM_012138	NP_036270	Q9NY61	AATF_HUMAN	Homo sapiens apoptosis antagonizing transcription factor (AATF), mRNA.	461	RB1 and SP1 binding.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of superoxide anion generation|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to DNA damage stimulus	centrosome|focal adhesion|nucleolus	leucine zipper domain binding|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)	18		Breast(25;0.00607)				CTTTGATGATGATGACTTTTA	0.373000														77			38		0	0	1	0	0
FLJ43860	389690	broad.mit.edu	37	8	142451278	142451278	+	Missense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:142451278G>A	uc003ywi.2	-	23	3121	c.3040C>T	c.(3040-3042)Cgt>Tgt	p.R1014C	FLJ43860_uc011ljs.1_Non-coding_Transcript|FLJ43860_uc010meu.1_Non-coding_Transcript	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	Homo sapiens FLJ43860 protein (FLJ43860), mRNA.	1015							binding					all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TTCCTCTCACGCTCCTGTGGG	0.637000														28			34		0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20808090	20808090	+	Missense_Mutation	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:20808090C>T	uc002npb.1	-	3	743	c.593G>A	c.(592-594)gGg>gAg	p.G198E	ZNF626_uc002npc.1_Missense_Mutation_p.G122E	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	Homo sapiens zinc finger protein 626 (ZNF626), transcript variant 1, mRNA.	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						GTAGGGTTTCCCTCCAGTATG	0.363000														92			4		0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176860178	176860178	+	Silent	SNP	T	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:176860178T>C	uc021yit.1	+	5	631	c.471T>C	c.(469-471)ccT>ccC	p.P157P	GRK6_uc003mgq.2_Silent_p.P157P|GRK6_uc021yiu.1_Silent_p.P157P|GRK6_uc003mgs.1_Silent_p.P127P	NM_001004106	NP_001004106	P43250	GRK6_HUMAN	Homo sapiens G protein-coupled receptor kinase 6 (GRK6), transcript variant 1, mRNA.	157	N-terminal.|RGS.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGTGGCCCCTTTTGCCGACT	0.627000														236			4		0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72863050	72863050	+	Silent	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:72863050C>T	uc010wrl.2	-	2	342	c.255G>A	c.(253-255)gcG>gcA	p.A85A	FDXR_uc010wri.2_Intron|FDXR_uc010wrj.2_Intron|FDXR_uc002jlw.3_Intron|FDXR_uc002jlx.3_Intron|FDXR_uc002jly.3_Intron|FDXR_uc010wrk.2_Intron|FDXR_uc010wrm.2_Intron|FDXR_uc002jlz.3_Intron|FDXR_uc002jmb.3_Intron	NM_024417	NP_077728	P22570	ADRO_HUMAN	Homo sapiens ferredoxin reductase (FDXR), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	59					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					GAGGCTGGGACGCCCCCAGGT	0.622000														11			5		0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101348096	101348096	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:101348096G>A	uc010txj.1	-	0	3089	c.3030C>T	c.(3028-3030)gcC>gcT	p.A1010A	MIR433_uc021scd.1_5'Flank|MIR127_uc001yig.3_5'Flank|MIR432_uc021sce.1_5'Flank|MIR136_uc010txk.1_5'Flank	NM_001134888	NP_001128360	E9PKS8	E9PKS8_HUMAN	Homo sapiens retrotransposon-like 1 (RTL1), mRNA.	1010										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TTTGCCTGGCGGCAGTGTTCC	0.577000														4			11		0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88442747	88442747	+	Missense_Mutation	SNP	G	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:88442747G>T	uc001xvt.3	-	6	814	c.707C>A	c.(706-708)tCc>tAc	p.S236Y	GALC_uc010tvw.1_Non-coding_Transcript|GALC_uc010tvy.2_Missense_Mutation_p.S213Y|GALC_uc010tvx.2_Missense_Mutation_p.S210Y|GALC_uc010tvz.1_Missense_Mutation_p.S180Y|GALC_uc001xvu.2_Missense_Mutation_p.S236Y	NM_000153	NP_000144	P54803	GALC_HUMAN	Homo sapiens galactosylceramidase (GALC), transcript variant 1, mRNA.	236					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AAGGAGCATGGATGCAGAGAT	0.398000														47			66		3.26865e-45	3.77151e-45	1	1	0
ZBTB43	23099	broad.mit.edu	37	9	129595533	129595533	+	Missense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:129595533G>A	uc022bnm.1	+	0	745	c.745G>A	c.(745-747)Gag>Aag	p.E249K	ZBTB43_uc004bql.3_Missense_Mutation_p.E249K|ZBTB43_uc010mxf.3_Missense_Mutation_p.E249K	NM_014007	NP_054726	O43298	ZBT43_HUMAN	Homo sapiens zinc finger and BTB domain containing 43 (ZBTB43), transcript variant 1, mRNA.	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						CGTGAAGCCCGAGCGCTTAGA	0.617000														6			18		0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164733006	164733006	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr3:164733006C>A	uc003fei.3	-	32	3967	c.3904G>T	c.(3904-3906)Gga>Tga	p.G1302*		NM_001041	NP_001032	P14410	SUIS_HUMAN	Homo sapiens sucrase-isomaltase (alpha-glucosidase) (SI), mRNA.	1302	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	Golgi apparatus|apical plasma membrane|brush border|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTTTCATTTCCTGAAATTGCT	0.348000										HNSCC(35;0.089)				32			34		1.36615e-20	1.51794e-20	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169111328	169111328	+	Silent	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:169111328C>T	uc003maf.3	+	7	815	c.735C>T	c.(733-735)taC>taT	p.Y245Y	DOCK2_uc011der.2_Non-coding_Transcript	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	Homo sapiens dedicator of cytokinesis 2 (DOCK2), mRNA.	245					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	GTP binding|GTPase binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding|electron carrier activity|heme binding	p.L244L(2)		NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTCTCTCTACGACCCCAACA	0.493000														198			66		0	0	1	0	0
TULP2	7288	broad.mit.edu	37	19	49398288	49398288	+	Nonsense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:49398288G>A	uc002pkz.2	-	5	632	c.481C>T	c.(481-483)Cga>Tga	p.R161*		NM_003323	NP_003314	O00295	TULP2_HUMAN	Homo sapiens tubby like protein 2 (TULP2), mRNA.	161					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		CCCTTGCGTCGGATTCTCGGA	0.522000														92			24		0	0	1	0	0
ZNF71	58491	broad.mit.edu	37	19	57132975	57132975	+	Missense_Mutation	SNP	G	A	A	rs139335499		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:57132975G>A	uc002qnm.4	+	2	558	c.320G>A	c.(319-321)cGt>cAt	p.R107H	ZNF71_uc021vcg.1_Missense_Mutation_p.R107H	NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	Homo sapiens zinc finger protein 71 (ZNF71), mRNA.	107						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CCCGTAAGGCGTGGCAAGAAC	0.582000														94			19		0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17406213	17406213	+	Missense_Mutation	SNP	T	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:17406213T>C	uc011kye.2	+	3	727	c.679T>C	c.(679-681)Tct>Cct	p.S227P	SLC7A2_uc011kyc.2_Missense_Mutation_p.S187P|SLC7A2_uc011kyd.2_Missense_Mutation_p.S227P	NM_001164771	NP_001158243	P52569	CTR2_HUMAN	Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (SLC7A2), transcript variant 3, mRNA.	187					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	AGTAAAAGAGTCTGCTTGGGT	0.373000														155			76		0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	44178123	44178123	+	Missense_Mutation	SNP	G	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr22:44178123G>T	uc003bdy.2	-	2	390	c.76C>A	c.(76-78)Cat>Aat	p.H26N	EFCAB6_uc003bdz.2_Intron|EFCAB6_uc010gzi.2_5'UTR|EFCAB6_uc011aqa.2_5'UTR|EFCAB6_uc003bea.2_Missense_Mutation_p.H23N|EFCAB6_uc003beb.4_5'UTR	NM_022785	NP_942153	Q5THR3	EFCB6_HUMAN	Homo sapiens EF-hand calcium binding domain 6 (EFCAB6), transcript variant 1, mRNA.	26					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GGTGAAGAATGGGGTCTTGAA	0.373000														198			11		2.23348e-06	2.42185e-06	1	1	0
LRRC45	201255	broad.mit.edu	37	17	79985969	79985969	+	Missense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:79985969G>A	uc002kde.3	+	8	1234	c.994G>A	c.(994-996)Gag>Aag	p.E332K		NM_144999	NP_659436	Q96CN5	LRC45_HUMAN	Homo sapiens leucine rich repeat containing 45 (LRRC45), mRNA.	332						centrosome				lung(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	5	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			AGCGGAGCAGGAGCAGCTGAG	0.682000														10			5		0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274379	39274379	+	Silent	SNP	G	A	A	rs411996	by1000genomes	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:39274379G>A	uc002hvz.3	-	0	228	c.189C>T	c.(187-189)acC>acT	p.T63T		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	Homo sapiens keratin associated protein 4-11 (KRTAP4-11), mRNA.	63	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GGCGGCAGCAGGTGGGCTGGC	0.657000														96			4		0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164785	139164785	+	Missense_Mutation	SNP	T	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:139164785T>G	uc003yuy.3	-	12	2104	c.1933A>C	c.(1933-1935)Agt>Cgt	p.S645R	FAM135B_uc003yux.3_Missense_Mutation_p.S546R|FAM135B_uc003yuz.3_Non-coding_Transcript|FAM135B_uc003yva.3_Missense_Mutation_p.S207R|FAM135B_uc003yvb.3_Missense_Mutation_p.S207R	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	Homo sapiens family with sequence similarity 135, member B (FAM135B), mRNA.	645										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGGGTAGAACTTAGTGGATCA	0.488000										HNSCC(54;0.14)				111			41		0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53855364	53855365	+	Missense_Mutation	DNP	CA	TG	TG			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:53855364_53855365CA>TG	uc010ydv.1	+	3	1553_1554	c.1436_1437CA>TG	c.(1435-1437)aca>aTG	p.T479M	ZNF845_uc010ydw.1_Missense_Mutation_p.T479M	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	Homo sapiens zinc finger protein 845 (ZNF845), mRNA.	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TTCAGTCAGACATCATCCCTTG	0.381000														214			5		0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85639647	85639647	+	Missense_Mutation	SNP	T	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr4:85639647T>C	uc003hpd.3	-	47	8090	c.7682A>G	c.(7681-7683)cAt>cGt	p.H2561R	WDFY3_uc003hpe.1_Missense_Mutation_p.H172R	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	Homo sapiens WD repeat and FYVE domain containing 3 (WDFY3), mRNA.	2561						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CACATAAAAATGCTCTTTACC	0.408000														54			72		0	0	1	0	0
ABCD3	5825	broad.mit.edu	37	1	94884036	94884036	+	Missense_Mutation	SNP	T	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:94884036T>A	uc010oto.2	+	0	104	c.2T>A	c.(1-3)aTg>aAg	p.M1K	ABCD3_uc001dqm.4_Missense_Mutation_p.M1K|ABCD3_uc001dqn.4_Missense_Mutation_p.M1K|ABCD3_uc010otp.2_5'UTR|ABCD3_uc009wdr.3_Missense_Mutation_p.M1K	NM_002858	NP_002849	P28288	ABCD3_HUMAN	Homo sapiens ATP-binding cassette, sub-family D (ALD), member 3 (ABCD3), transcript variant 1, mRNA.	1	Interaction with PEX19.|Targeting to peroxisomes.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		GGCAGTGCCATGGCGGCCTTC	0.726000														31			3		0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86123866	86123866	+	Missense_Mutation	SNP	T	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:86123866T>G	uc002blv.1	+	6	2737	c.2567T>G	c.(2566-2568)cTt>cGt	p.L856R	AKAP13_uc002blt.1_Missense_Mutation_p.L856R|AKAP13_uc002blu.1_Missense_Mutation_p.L856R|AKAP13_uc010bne.1_5'Flank	NM_007200	NP_009131	Q12802	AKP13_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 13 (AKAP13), transcript variant 2, mRNA.	856					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	Rho guanyl-nucleotide exchange factor activity|cAMP-dependent protein kinase activity|metal ion binding|protein binding|signal transducer activity	p.E855_G859>G(2)		NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GCTGCAGAGCTTCAGCACGGG	0.552000														125			49		0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90321631	90321631	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:90321631G>A	uc004apc.3	+	25	3783	c.3645G>A	c.(3643-3645)gtG>gtA	p.V1215V	DAPK1_uc004apd.3_Silent_p.V1215V|DAPK1_uc011ltg.2_Silent_p.V1149V|DAPK1_uc011lth.2_Silent_p.V952V|DAPK1_uc004apg.2_Silent_p.V192V	NM_004938	NP_004929	P53355	DAPK1_HUMAN	Homo sapiens death-associated protein kinase 1 (DAPK1), mRNA.	1215					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TGGACTCGGTGTGCAGCACCA	0.642000									Chronic Lymphocytic Leukemia, Familial Clustering of					32			3		0	0	1	0	0
DPY19L1	23333	broad.mit.edu	37	7	34997678	34997678	+	Missense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr7:34997678G>A	uc003tem.4	-	10	1023	c.878C>T	c.(877-879)tCt>tTt	p.S293F		NM_015283	NP_056098	Q2PZI1	D19L1_HUMAN	Homo sapiens dpy-19-like 1 (C. elegans) (DPY19L1), mRNA.	293						integral to membrane				endometrium(3)|kidney(5)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	31						AAGTGCAAGAGAAATCTGGAA	0.279000														16			20		0	0	1	0	0
GEM	2669	broad.mit.edu	37	8	95262715	95262715	+	Missense_Mutation	SNP	C	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:95262715C>A	uc003ygi.3	-	4	838	c.714G>T	c.(712-714)caG>caT	p.Q238H	GEM_uc003ygj.3_Missense_Mutation_p.Q238H	NM_181702	NP_859053	P55040	GEM_HUMAN	Homo sapiens GTP binding protein overexpressed in skeletal muscle (GEM), transcript variant 2, mRNA.	238					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	GDP binding|GTP binding|GTPase activity|calmodulin binding|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			GAAGGCGCACCTGTCGCACAA	0.582000														71			67		1.30681e-28	1.48877e-28	1	1	0
SCN1A	6323	broad.mit.edu	37	2	166892972	166892972	+	Silent	SNP	A	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:166892972A>G	uc002udo.4	-	17	3242	c.3015T>C	c.(3013-3015)gaT>gaC	p.D1005D	SCN1A_uc010fpk.3_Silent_p.D977D|SCN1A_uc021vsb.1_Silent_p.D994D	NM_001202435	NP_001189364	P35498	SCN1A_HUMAN	Homo sapiens sodium channel, voltage-gated, type I, alpha subunit (SCN1A), transcript variant 4, mRNA.	1005						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTTCATTATCATCATCAGTGG	0.343000														28			21		0	0	1	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783741	149783741	+	Silent	SNP	C	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:149783741C>G	uc010pbk.2	-	0	188	c.138G>C	c.(136-138)ctG>ctC	p.L46L	HIST2H2BF_uc010pbj.2_Silent_p.L46L|HIST2H2BF_uc001esr.3_Silent_p.L46L	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	Homo sapiens histone cluster 2, H2bf (HIST2H2BF), transcript variant 1, mRNA.	46					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)					GGACCTGCTTCAGCACCTTGT	0.582000														365			264		0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126329750	126329750	+	Silent	SNP	A	G	G	rs145529167		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr4:126329750A>G	uc003ifj.4	+	3	5721	c.5721A>G	c.(5719-5721)gaA>gaG	p.E1907E	FAT4_uc011cgp.2_Silent_p.E205E	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	Homo sapiens FAT tumor suppressor homolog 4 (Drosophila) (FAT4), mRNA.	1907	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TAGATTATGAAGTACAGCAAT	0.328000														33			52		0	0	1	0	0
STAMBP	10617	broad.mit.edu	37	2	74058084	74058084	+	Missense_Mutation	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:74058084G>A	uc002sju.3	+	2	303	c.101G>A	c.(100-102)cGt>cAt	p.R34H	STAMBP_uc002sjs.3_Missense_Mutation_p.R34H|STAMBP_uc002sjv.3_Missense_Mutation_p.R34H	NM_006463	NP_998787	O95630	STABP_HUMAN	Homo sapiens STAM binding protein (STAMBP), transcript variant 1, mRNA.	34	Interaction with CHMP3.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	18						ATTCCACCCCGTCGGTACTTC	0.517000														80			85		0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105179417	105179417	+	Silent	SNP	C	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:105179417C>A	uc001kwy.1	+	15	2316	c.2229C>A	c.(2227-2229)ggC>ggA	p.G743G		NM_014976	NP_055791	Q14690	RRP5_HUMAN	Homo sapiens programmed cell death 11 (PDCD11), mRNA.	743	S1 motif 8.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AGGACTATGGCGTGTTCATCC	0.493000														89			3		1	1	1	1	0
ACOT4	122970	broad.mit.edu	37	14	74059007	74059007	+	Missense_Mutation	SNP	A	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:74059007A>G	uc001xoo.3	+	0	598	c.344A>G	c.(343-345)gAg>gGg	p.E115G		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	Homo sapiens acyl-CoA thioesterase 4 (ACOT4), mRNA.	115					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(234;0.00331)		CACGACCCCGAGCCTGGACGG	0.692000														20			9		0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106717367	106717367	+	Missense_Mutation	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr12:106717367C>T	uc001tln.3	+	5	889	c.715C>T	c.(715-717)Cgc>Tgc	p.R239C	TCP11L2_uc001tll.3_Missense_Mutation_p.R239C|TCP11L2_uc001tlm.3_Missense_Mutation_p.R239C	NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	Homo sapiens t-complex 11 (mouse)-like 2 (TCP11L2), mRNA.	239										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						GCACCTTCAACGCCAGTTGGT	0.338000														166			6		0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137650106	137650106	+	Silent	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:137650106C>T	uc004cfe.3	+	17	2281	c.1899C>T	c.(1897-1899)gaC>gaT	p.D633D		NM_000093	NP_000084	P20908	CO5A1_HUMAN	Homo sapiens collagen, type V, alpha 1 (COL5A1), mRNA.	633	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGGGTTTCGACGGCCTGGCTG	0.627000														10			67		0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110839549	110839549	+	Missense_Mutation	SNP	G	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr13:110839549G>T	uc001vqw.4	-	24	1786	c.1664C>A	c.(1663-1665)aCa>aAa	p.T555K		NM_001845	NP_001836	P02462	CO4A1_HUMAN	Homo sapiens collagen, type IV, alpha 1 (COL4A1), mRNA.	555	Triple-helical region.		T -> P (in dbSNP:rs536174).		angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding	p.P555Q(2)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CGCTCTCCCTGTCATGCCGGG	0.572000														146			8		5.18039e-06	5.55042e-06	1	1	0
PPEF2	5470	broad.mit.edu	37	4	76797597	76797597	+	Missense_Mutation	SNP	C	T	T	rs140029551	byFrequency	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr4:76797597C>T	uc003hix.3	-	10	1520	c.1163G>A	c.(1162-1164)cGg>cAg	p.R388Q	PPEF2_uc003hiy.3_Non-coding_Transcript|PPEF2_uc003hiz.1_Missense_Mutation_p.R388Q	NM_006239	NP_006230	O14830	PPE2_HUMAN	Homo sapiens protein phosphatase, EF-hand calcium binding domain 2 (PPEF2), mRNA.	388	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	Hsp70 protein binding|Hsp90 protein binding|calcium ion binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity	p.R388W(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CCGCACCTGCCGGGAGAGCTC	0.672000														39			17		0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109734382	109734382	+	Missense_Mutation	SNP	C	T	T	rs41279692		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:109734382C>T	uc021orb.1	+	12	1801	c.1580C>T	c.(1579-1581)aCg>aTg	p.T527M	KIAA1324_uc009wex.2_Missense_Mutation_p.T477M|KIAA1324_uc010ovg.2_Missense_Mutation_p.T425M|KIAA1324_uc009wey.3_Missense_Mutation_p.T440M|KIAA1324_uc001dwr.3_Missense_Mutation_p.T177M	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	Homo sapiens KIAA1324 (KIAA1324), mRNA.	527					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane		p.T527T(1)		NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CCTGTGGAGACGTGGAAAGGT	0.537000														23			134		0	0	1	0	0
CSNK1G1	53944	broad.mit.edu	37	15	64499781	64499781	+	Missense_Mutation	SNP	C	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:64499781C>G	uc002anf.3	-	6	1172	c.692G>C	c.(691-693)aGa>aCa	p.R231T	CSNK1G1_uc002ane.3_Non-coding_Transcript|CSNK1G1_uc002ang.1_Missense_Mutation_p.R231T|CSNK1G1_uc002anh.1_Missense_Mutation_p.R231T|CSNK1G1_uc002anj.3_Missense_Mutation_p.R213T	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	Homo sapiens casein kinase 1, gamma 1 (CSNK1G1), mRNA.	231	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	13						CAAATCATCTCTCCGGCTTTG	0.453000														52			16		0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477718	88477718	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr14:88477718T>A	uc021rxh.1	+	0	527	c.527T>A	c.(526-528)tTa>tAa	p.L176*	GPR65_uc001xvv.3_Nonsense_Mutation_p.L176*	NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA.	176					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						AAATACCCTTTAGAGAAATGG	0.408000														106			41		0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38407208	38407208	+	Silent	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:38407208C>T	uc003jlc.2	+	7	1453	c.1107C>T	c.(1105-1107)tgC>tgT	p.C369C	EGFLAM_uc003jlb.2_Silent_p.C369C|EGFLAM_uc003jle.2_Silent_p.C135C|EGFLAM_uc003jlf.2_Intron	NM_001205301	NP_001192230	Q63HQ2	EGFLA_HUMAN	Homo sapiens EGF-like, fibronectin type III and laminin G domains (EGFLAM), transcript variant 5, mRNA.	369	EGF-like 1.					cell junction|proteinaceous extracellular matrix|synapse		p.R368Q(2)		NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GCTCGCGATGCCAGTGCACCC	0.552000														77			29		0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16021583	16021583	+	Missense_Mutation	SNP	A	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr8:16021583A>T	uc010lsu.3	-	4	926	c.862T>A	c.(862-864)Tta>Ata	p.L288I	MSR1_uc003wwz.3_Missense_Mutation_p.L270I|MSR1_uc003wxa.3_Missense_Mutation_p.L270I|MSR1_uc003wxb.3_Missense_Mutation_p.L270I|MSR1_uc011kxz.2_Missense_Mutation_p.L44I	NM_138715	NP_619729	P21757	MSRE_HUMAN	Homo sapiens macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI, mRNA.	270	Collagen-like.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CCTTGAATTAAAGTGATATTT	0.303000														62			33		0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79060510	79060511	+	Missense_Mutation	DNP	TT	GC	GC			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr15:79060510_79060511TT>GC	uc002bej.4	-	16	2820_2821	c.2609_2610AA>GC	c.(2608-2610)caa>cGC	p.Q870R	ADAMTS7_uc010und.1_Missense_Mutation_p.Q446R	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 7 (ADAMTS7), mRNA.	870	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						ACTTCCTCTGTTGGTCATCAGG	0.693000														36			3		0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9496748	9496748	+	Silent	SNP	C	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr20:9496748C>G	uc002wni.2	+	2	834	c.339C>G	c.(337-339)cgC>cgG	p.R113R	LAMP5_uc010zrc.2_Intron	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	Homo sapiens lysosomal-associated membrane protein family, member 5 (LAMP5), transcript variant 1, mRNA.	113						integral to membrane											GGGTGGATCGCGCATATGCAC	0.617000														46			13		0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186277987	186277987	+	Missense_Mutation	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:186277987C>T	uc001gru.4	+	6	3187	c.3136C>T	c.(3136-3138)Cca>Tca	p.P1046S	MIR548F1_uc021pgf.1_Intron|PRG4_uc001grt.4_Missense_Mutation_p.P1005S|PRG4_uc009wyl.3_Missense_Mutation_p.P953S|PRG4_uc009wym.3_Missense_Mutation_p.P912S|PRG4_uc010poo.2_Non-coding_Transcript	NM_005807	NP_005798	Q92954	PRG4_HUMAN	Homo sapiens proteoglycan 4 (PRG4), transcript variant A, mRNA.	1046					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						AGTGAGAAAACCAAAGACGAC	0.448000														33			62		0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201195105	201195105	+	Missense_Mutation	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:201195105C>T	uc001gwc.3	+	21	10770	c.10640C>T	c.(10639-10641)gCa>gTa	p.A3547V	IGFN1_uc001gwb.3_Non-coding_Transcript	NM_001164586	NP_001158058			Homo sapiens immunoglobulin-like and fibronectin type III domain containing 1 (IGFN1), mRNA.											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TGGCACGAGGCAGCCGACCGC	0.667000														84			18		0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23701589	23701589	+	Silent	SNP	A	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr9:23701589A>G	uc003zpu.3	-	4	776	c.501T>C	c.(499-501)ggT>ggC	p.G167G	ELAVL2_uc003zps.3_Silent_p.G167G|ELAVL2_uc003zpt.3_Silent_p.G167G|ELAVL2_uc003zpv.3_Silent_p.G167G|ELAVL2_uc003zpw.3_Silent_p.G167G	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	Homo sapiens ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) (ELAVL2), transcript variant 1, mRNA.	167	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding	p.G167D(1)		breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TAAACCCTACACCCCTTGATA	0.438000														107			5		0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90578514	90578514	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr6:90578514G>A	uc003pnr.3	+	7	5701	c.5505G>A	c.(5503-5505)aaG>aaA	p.K1835K	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.3_Silent_p.K1835K|CASP8AP2_uc011dzz.2_Silent_p.K1835K	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	Homo sapiens caspase 8 associated protein 2 (CASP8AP2), transcript variant 2, mRNA.	1835	NCOA2-binding.				cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTCACAAAAAGAGAAGAAACA	0.343000														10			7		0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62290231	62290231	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:62290231G>A	uc002jed.3	-	1	1498	c.1347C>T	c.(1345-1347)ctC>ctT	p.L449L	TEX2_uc002jec.3_Silent_p.L449L|TEX2_uc002jee.3_Silent_p.L449L	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	Homo sapiens testis expressed 2 (TEX2), mRNA.	449					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CATCTTCCGCGAGCACCTCTG	0.507000														230			66		0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102221100	102221100	+	Nonsense_Mutation	SNP	C	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr11:102221100C>A	uc001pgy.3	+	1	1914	c.515C>A	c.(514-516)tCg>tAg	p.S172*	BIRC2_uc010ruq.2_Nonsense_Mutation_p.S123*|BIRC2_uc010rur.2_Nonsense_Mutation_p.S172*	NM_001166	NP_001157	Q13490	BIRC2_HUMAN	Homo sapiens baculoviral IAP repeat containing 2 (BIRC2), mRNA.	172					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		ATCTCTTCATCGAGGACTAAC	0.418000														134			4		1	1	1	1	0
PACS1	55690	broad.mit.edu	37	11	65983735	65983735	+	Splice_Site	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr11:65983735G>A	uc001oha.2	+	5	939	c.805_splice	c.e5+1	p.D269_splice	PACS1_uc001ogz.1_Splice_Site_p.D269_splice	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	Homo sapiens phosphofurin acidic cluster sorting protein 1 (PACS1), mRNA.	269					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						AAGCTTTCTGGTAAGAAGCAT	0.498000														44			6		0	0	1	0	0
ACAP2	23527	broad.mit.edu	37	3	195102638	195102638	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr3:195102638G>A	uc003fun.4	-	2	466	c.225C>T	c.(223-225)gtC>gtT	p.V75V	ACAP2_uc003fuo.3_Silent_p.V75V	NM_012287	NP_036419	Q15057	ACAP2_HUMAN	Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 (ACAP2), mRNA.	75	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						TAACCTCAACGACAGCATCAT	0.323000														63			7		0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544867	23544867	+	Missense_Mutation	SNP	T	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:23544867T>C	uc002nre.3	-	3	1027	c.914A>G	c.(913-915)cAt>cGt	p.H305R	ZNF91_uc010xrj.2_Missense_Mutation_p.H273R	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	Homo sapiens zinc finger protein 91 (ZNF91), mRNA.	305						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAATGGCTAAAAGC	0.413000														189			8		0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25145722	25145722	+	Missense_Mutation	SNP	T	C	C			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr22:25145722T>C	uc003abd.1	-	9	1571	c.1154A>G	c.(1153-1155)aAg>aGg	p.K385R	PIWIL3_uc011ajx.1_Missense_Mutation_p.K276R|PIWIL3_uc010gut.1_Missense_Mutation_p.K385R|PIWIL3_uc011ajy.1_Missense_Mutation_p.K276R	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	Homo sapiens piwi-like 3 (Drosophila) (PIWIL3), transcript variant 1, mRNA.	385	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding	p.K384*(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						CGTTAGGCCCTTTTTCCATCT	0.468000														109			3		0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57187809	57187809	+	Missense_Mutation	SNP	T	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr7:57187809T>G	uc010kzo.3	-	4	1584	c.1313A>C	c.(1312-1314)aAa>aCa	p.K438T		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	Homo sapiens zinc finger protein 479 (ZNF479), mRNA.	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCTTCACATTTGTAGGGTCT	0.453000														158			7		0	0	1	0	0
LOC650623	650623	broad.mit.edu	37	10	81443781	81443781	+	RNA	SNP	A	T	T	rs143569743	by1000genomes	TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:81443781A>T	uc010qlu.2	+	0		c.1051A>T								Homo sapiens BEN domain containing 3 pseudogene (LOC650623), non-coding RNA.																		GACCACAAAGACGAGGAGGAG	0.622000														26			5		0	0	1	0	0
NSA2	10412	broad.mit.edu	37	5	74072447	74072447	+	Missense_Mutation	SNP	C	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:74072447C>T	uc003kdk.1	+	5	817	c.734C>T	c.(733-735)aCc>aTc	p.T245I		NM_014886	NP_055701	O95478	NSA2_HUMAN	Homo sapiens NSA2 ribosome biogenesis homolog (S. cerevisiae) (NSA2), mRNA.	245					rRNA processing	nucleolus|ribonucleoprotein complex				breast(1)|endometrium(2)|kidney(1)|lung(1)|ovary(1)|skin(1)	7						GCCCAGGTTACCAACAATCCT	0.318000														127			96		0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1232963	1232963	+	Silent	SNP	G	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:1232963G>A	uc003jby.2	+	2	522	c.399G>A	c.(397-399)ccG>ccA	p.P133P		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	Homo sapiens solute carrier family 6, member 18 (SLC6A18), mRNA.	133					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCCAGCACCCGCTGCCCTGGA	0.642000														203			48		0	0	1	0	0
SGCA	6442	broad.mit.edu	37	17	48246488	48246488	+	Missense_Mutation	SNP	C	G	G			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:48246488C>G	uc002iqi.3	+	5	656	c.620C>G	c.(619-621)tCt>tGt	p.S207C	SGCA_uc010wmh.1_Missense_Mutation_p.S105C|SGCA_uc002iqj.3_Intron|SGCA_uc010wmi.2_Non-coding_Transcript|BC126901_uc010dbn.1_5'Flank	NM_000023	NP_000014	Q16586	SGCA_HUMAN	Homo sapiens sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) (SGCA), transcript variant 1, mRNA.	207					muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(2)|skin(1)	14						TCACCTTTTTCTACTTGCCTG	0.592000											OREG0024558	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		89			67		0	0	1	0	0
PCP4L1	654790	broad.mit.edu	37	1	161254154	161254156	+	In_Frame_Del	DEL	GGA	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr1:161254154_161254156delGGA	uc001gad.3	+	2	338_340	c.90_92delGGA	c.(88-93)gcggag>gcg	p.E35del		NM_001102566	NP_001096036	A6NKN8	PC4L1_HUMAN	Homo sapiens Purkinje cell protein 4 like 1 (PCP4L1), mRNA.	35								p.E35delE(2)|p.A30A(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4	all_cancers(52;4.16e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TCAAGAAGGCGGAGGAGGAGGAG	0.488													---	382	---	---	8	---					
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	-	-	rs112040677		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr2:131129929_131129934delGACGGG	uc002trc.3	+	12	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cagacgggg>cag	p.TG378del	PTPN18_uc002trb.3_In_Frame_Del_p.TG271del|PTPN18_uc002tre.3_In_Frame_Del_p.TG29del	NM_014369	NP_055184	Q99952	PTN18_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 18 (brain-derived) (PTPN18), transcript variant 1, mRNA.	378				Missing (in Ref. 1; CAA56105).		cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(2)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													---	4	---	---	3	---					
VCAN	1462	broad.mit.edu	37	5	82816057	82816057	+	Frame_Shift_Del	DEL	T	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr5:82816057delT	uc003kii.3	+	6	2288	c.1932delT	c.(1930-1932)cctfs	p.P644fs	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Frame_Shift_Del_p.P644fs|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	Homo sapiens versican (VCAN), transcript variant 1, mRNA.	644	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding	p.T643I(1)		NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTACTACACCTTTTCCATCAC	0.368													---	849	---	---	8	---					
PTEN	5728	broad.mit.edu	37	10	89693002	89693003	+	Frame_Shift_Ins	INS	-	A	A			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:89693002_89693003insA	uc001kfb.3	+	4	1518_1519	c.486_487insA	c.(484-489)gacaaafs	p.D162fs	PTEN_uc021pvw.1_Non-coding_Transcript	NM_000314	NP_000305	P60484	PTEN_HUMAN	Homo sapiens phosphatase and tensin homolog (PTEN), mRNA.	162	Phosphatase tensin-type.				T cell receptor signaling pathway|activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development	PML body|cytosol|internal side of plasma membrane	PDZ domain binding|anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.K163*(4)|p.R161I(2)|p.Y27fs*1(2)|p.R161K(2)|p.Y27_N212>Y(2)|p.D162fs*8(2)|p.R161G(1)|p.K163_V166>NKGE(1)|p.D162H(1)|p.D162V(1)|p.F56fs*2(1)|p.D162G(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		GGACCAGAGACAAAAAGGTAAG	0.351		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			---	8	---	---	43	---					
HPS1	3257	broad.mit.edu	37	10	100186987	100186987	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr10:100186987delG	uc021pwv.1	-	10	1218	c.972delC	c.(970-972)cccfs	p.P324fs	HPS1_uc010qpg.2_5'Flank|HPS1_uc009xwb.3_Non-coding_Transcript|HPS1_uc010qph.1_Frame_Shift_Del_p.P324fs	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Homo sapiens Hermansky-Pudlak syndrome 1 (HPS1), transcript variant 1, mRNA.	324					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity	p.M325fs*128(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		GGGCATCCATGGGGGGGGTGC	0.572									Hermansky-Pudlak syndrome				---	4	---	---	2	---					
ZCCHC14	23174	broad.mit.edu	37	16	87445976	87445979	+	Frame_Shift_Del	DEL	GCAG	-	-	rs143691635		TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr16:87445976_87445979delGCAG	uc002fjz.1	-	11	1964_1967	c.1937_1940delCTGC	c.(1936-1941)cctgctfs	p.P646fs	ZCCHC14_uc002fka.1_Non-coding_Transcript|ZCCHC14_uc002fkb.3_Frame_Shift_Del_p.P422fs	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	Homo sapiens zinc finger, CCHC domain containing 14 (ZCCHC14), mRNA.	646					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GGCAGAATCAGCAGGAACAGATGA	0.583													---	325	---	---	73	---					
FANCA	2175	broad.mit.edu	37	16	89806404	89806405	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr16:89806404_89806405delCT	uc002fou.1	-	38	3973_3974	c.3931_3932delAG	c.(3931-3933)agtfs	p.S1311fs	ZNF276_uc010ciq.3_3'UTR|ZNF276_uc002foq.4_3'UTR|ZNF276_uc010cir.3_Non-coding_Transcript|ZNF276_uc002for.4_3'UTR|ZNF276_uc010cis.3_3'UTR|ZNF276_uc002fos.4_3'UTR|ZNF276_uc002fot.4_Non-coding_Transcript|ZNF276_uc010vpm.2_3'UTR|FANCA_uc010vpn.1_Frame_Shift_Del_p.S1311fs|FANCA_uc010vpo.2_Frame_Shift_Del_p.S397fs	NM_000135	NP_000126	O15360	FANCA_HUMAN	Homo sapiens Fanconi anemia, complementation group A (FANCA), transcript variant 1, mRNA.	1311					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			breast(5)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|urinary_tract(3)	47		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		TTTCTTACCACTCTCTGTCAAC	0.510			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				---	214	---	---	70	---					
MYO1C	4641	broad.mit.edu	37	17	1378283	1378284	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:1378283_1378284insT	uc002fsp.3	-	14	1837_1838	c.1617_1618insA	c.(1615-1620)cgagggfs	p.R539fs	MYO1C_uc002fsn.3_Frame_Shift_Ins_p.R520fs|MYO1C_uc002fso.3_Frame_Shift_Ins_p.R504fs|MYO1C_uc010vqj.1_Frame_Shift_Ins_p.R504fs|MYO1C_uc010vqk.1_Frame_Shift_Ins_p.R515fs	NM_001080779	NP_203693	O00159	MYO1C_HUMAN	Homo sapiens myosin IC (MYO1C), transcript variant 1, mRNA.	539	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	ATP binding|actin binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CGGAATTCCCCTCGGCCCAGAG	0.668													---	4	---	---	2	---					
DNAH9	1770	broad.mit.edu	37	17	11837333	11837333	+	Frame_Shift_Del	DEL	C	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:11837333delC	uc002gne.3	+	64	12502	c.12434delC	c.(12433-12435)tctfs	p.S4145fs	DNAH9_uc010coo.3_Frame_Shift_Del_p.S3363fs|DNAH9_uc002gnf.3_Frame_Shift_Del_p.S457fs	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	Homo sapiens dynein, axonemal, heavy chain 9 (DNAH9), transcript variant 2, mRNA.	4145					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGAGAACTGTCTTTGGCCCCA	0.502													---	147	---	---	73	---					
NF1	4763	broad.mit.edu	37	17	29553542	29553542	+	Frame_Shift_Del	DEL	C	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr17:29553542delC	uc002hgg.3	+	17	2474	c.2091delC	c.(2089-2091)aacfs	p.N697fs	NF1_uc002hgh.3_Frame_Shift_Del_p.N697fs|NF1_uc010csn.2_Frame_Shift_Del_p.N557fs|NF1_uc002hgi.1_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	Homo sapiens neurofibromin 1 (NF1), transcript variant 1, mRNA.	697					MAPKKK cascade|Ras protein signal transduction|actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|metanephros development|myelination in peripheral nervous system|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	Ras GTPase activator activity|protein binding	p.0?(8)|p.?(4)|p.W696fs*1(2)|p.W696*(1)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTCTGTGGAACCCTGACACTG	0.542			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			---	44	---	---	113	---					
GATA6	2627	broad.mit.edu	37	18	19752073	19752075	+	In_Frame_Del	DEL	ACC	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr18:19752073_19752075delACC	uc002ktt.1	+	1	1233_1235	c.968_970delACC	c.(967-972)taccac>tac	p.H333del	GATA6_uc002ktu.1_In_Frame_Del_p.H333del	NM_005257	NP_005248	Q92908	GATA6_HUMAN	Homo sapiens GATA binding protein 6 (GATA6), mRNA.	333	Poly-His.				blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			AACGGGACGTaccaccaccacca	0.749													---	4	---	---	2	---					
NUCB1	4924	broad.mit.edu	37	19	49425109	49425111	+	In_Frame_Del	DEL	AGC	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr19:49425109_49425111delAGC	uc002plb.4	+	11	1533_1535	c.1199_1201delAGC	c.(1198-1203)aagcag>aag	p.Q407del	Mir_324_uc021uxc.1_5'Flank|NUCB1_uc002pld.3_In_Frame_Del_p.Q70del	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	Homo sapiens nucleobindin 1 (NUCB1), mRNA.	407	Poly-Gln.					ER-Golgi intermediate compartment|Golgi apparatus|extracellular space|membrane|microtubule cytoskeleton	DNA binding|calcium ion binding			cervix(1)|endometrium(4)|large_intestine(4)|lung(8)	17		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		Gagcagcggaagcagcagcagca	0.640													---	155	---	---	8	---					
MICAL3	57553	broad.mit.edu	37	22	18314825	18314827	+	In_Frame_Del	DEL	CTC	-	-			TCGA-FW-A3I3-06A-11D-A21A-08	TCGA-FW-A3I3-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8fd25d1-50ab-411d-808f-99c7ab5204e8	adb99082-b96d-44ec-a501-42b05ca8dd7c	g.chr22:18314825_18314827delCTC	uc002zng.4	-	20	3201_3203	c.2848_2850delGAG	c.(2848-2850)gagdel	p.E950del	MICAL3_uc011agl.2_In_Frame_Del_p.E950del	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	Homo sapiens microtubule associated monoxygenase, calponin and LIM domain containing 3 (MICAL3), transcript variant 1, mRNA.	950	Glu-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GCAGGCGAGGctcctcctcctcc	0.557													---	41	---	---	7	---