Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCDHGC5	56097	broad.mit.edu	37	5	140750027	140750027	+	Silent	SNP	C	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:140750027C>G	uc003ljw.2	+	0	66	c.66C>G	c.(64-66)ctC>ctG	p.L22L	PCDHGC5_uc003lji.2_Intron|PCDHGC5_uc003ljk.2_Intron|PCDHGC5_uc003ljm.2_Intron|PCDHGC5_uc003ljo.2_Intron|PCDHGC5_uc003ljq.2_Intron|PCDHGC5_uc003ljs.2_Intron|PCDHGC5_uc003lju.2_Intron|PCDHGC5_uc011dat.2_Silent_p.L22L	NM_018924	NP_061747	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily B, 3 (PCDHGB3), transcript variant 1, mRNA.	0					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTCCTGCTCTCTTTGTTAG	0.587000														22			4		0	0	2.56e-06	0	0
CSH1	1442	broad.mit.edu	37	17	61972893	61972893	+	Silent	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr17:61972893C>T	uc002jcs.2	-	3	546	c.396G>A	c.(394-396)tcG>tcA	p.S132S		NM_001317	NP_001308	P01243	CSH_HUMAN	Homo sapiens chorionic somatomammotropin hormone 1 (placental lactogen) (CSH1), mRNA.	132					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding	p.S132S(2)		central_nervous_system(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						CATCGCTGTCCGAGGTGTCAT	0.592000									Russell-Silver syndrome					10			8		0	0	6.40141e-05	0	0
DHX30	22907	broad.mit.edu	37	3	47882497	47882497	+	Missense_Mutation	SNP	G	A	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr3:47882497G>A	uc003cru.3	+	6	923	c.497G>A	c.(496-498)cGg>cAg	p.R166Q	DHX30_uc003crs.2_Missense_Mutation_p.R127Q|DHX30_uc003crt.3_Missense_Mutation_p.R127Q|DHX30_uc010hjr.1_Missense_Mutation_p.R194Q	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 30 (DHX30), transcript variant 1, mRNA.	166						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|RNA binding|protein binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		ACTTCCTGGCGGCAGCTGAAT	0.597000														8			5		0	0	1.23904e-05	0	0
SLC22A12	116085	broad.mit.edu	37	11	64366364	64366364	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr11:64366364C>A	uc001oam.1	+	5	1786	c.1039C>A	c.(1039-1041)Cgc>Agc	p.R347S	SLC22A12_uc009ypr.1_Missense_Mutation_p.R372S|SLC22A12_uc001oal.1_Missense_Mutation_p.R126S|SLC22A12_uc009yps.1_Missense_Mutation_p.R313S|SLC22A12_uc001oan.1_Missense_Mutation_p.R239S|SLC22A12_uc009ypt.3_Missense_Mutation_p.R165S	NM_144585	NP_700357	Q96S37	S22AC_HUMAN	Homo sapiens solute carrier family 22 (organic anion/urate transporter), member 12 (SLC22A12), transcript variant 1, mRNA.	347					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						GCCCGGACTGCGCTTCCGGAC	0.667000														12			10		6.40141e-05	0.0046469	6.40141e-05	1	0
TUBB3	10381	broad.mit.edu	37	16	89985811	89985811	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr16:89985811G>C	uc002fpf.2	+	0	553	c.145G>C	c.(145-147)Ggg>Cgg	p.G49R	TUBB3_uc002fpe.4_Missense_Mutation_p.G49R|TUBB3_uc010ciz.1_5'Flank	NM_006086	NP_006077	Q13509	TBB3_HUMAN	Homo sapiens tubulin, beta 3 class III (TUBB3), transcript variant 1, mRNA.	0					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CCTCAGCCTGGGGCTGGTGAG	0.647000														18			3		0	0	6.4e-05	0	0
NMRAL1	57407	broad.mit.edu	37	16	4511935	4511935	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr16:4511935A>G	uc002cwm.3	-	5	902	c.746T>C	c.(745-747)cTt>cCt	p.L249P	NMRAL1_uc002cwn.3_Missense_Mutation_p.L249P|NMRAL1_uc002cwo.3_Missense_Mutation_p.L249P	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	Homo sapiens NmrA-like family domain containing 1 (NMRAL1), mRNA.	249						nucleus|perinuclear region of cytoplasm	binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|prostate(2)|stomach(1)	15						GGGAAAGCCAAGCTTTTCGTA	0.647000														29			27		0	0	0.000147802	0	0
MBTD1	54799	broad.mit.edu	37	17	49270312	49270312	+	Silent	SNP	A	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr17:49270312A>G	uc002itr.4	-	14	1865	c.1521T>C	c.(1519-1521)cgT>cgC	p.R507R	MBTD1_uc002itp.4_Silent_p.R343R|MBTD1_uc002itq.4_3'UTR	NM_017643	NP_060113	Q05BQ5	MBTD1_HUMAN	Homo sapiens mbt domain containing 1 (MBTD1), mRNA.	507					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)			CACATATTAAACGTGGCTCCA	0.388000														67			48		0	0	0.000147903	0	0
TNC	3371	broad.mit.edu	37	9	117808817	117808817	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr9:117808817A>C	uc004bjj.4	-	16	5409	c.4997T>G	c.(4996-4998)aTa>aGa	p.I1666R	TNC_uc010mvf.3_Intron|TNC_uc022bmj.1_Missense_Mutation_p.I1303R	NM_002160	NP_002151	P24821	TENA_HUMAN	Homo sapiens tenascin C (TNC), mRNA.	1666	Fibronectin type-III 12.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						AAGTAGGGTTATTTCCAGTGG	0.473000														58			4		0	0	2.56e-06	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106109035	106109035	+	Missense_Mutation	SNP	T	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chrX:106109035T>G	uc004emo.3	+	15	2599	c.2434T>G	c.(2434-2436)Tta>Gta	p.L812V	MORC4_uc004emp.4_Intron	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	Homo sapiens TBC1 domain family, member 8B (with GRAM domain) (TBC1D8B), transcript variant 1, mRNA.	812						intracellular	Rab GTPase activator activity|calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AGAGCTGTTTTTATCTTGTTA	0.328000														67			47		0	0	0.000125731	0	0
STK38	11329	broad.mit.edu	37	6	36467713	36467713	+	Missense_Mutation	SNP	T	C	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr6:36467713T>C	uc003omg.3	-	8	1477	c.889A>G	c.(889-891)Acc>Gcc	p.T297A	STK38_uc003omh.3_Missense_Mutation_p.T297A|STK38_uc003omi.3_Missense_Mutation_p.T297A	NM_007271	NP_009202	Q15208	STK38_HUMAN	Homo sapiens serine/threonine kinase 38 (STK38), mRNA.	297	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	MLL5-L complex|cytoplasm	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity	p.Q296L(1)		NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGTACCCGGTCTGCATGAAC	0.522000														62			7		0	0	8.12818e-05	0	0
UBIAD1	29914	broad.mit.edu	37	1	11333715	11333715	+	Missense_Mutation	SNP	A	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:11333715A>G	uc001asg.3	+	0	461	c.127A>G	c.(127-129)Agg>Ggg	p.R43G		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	Homo sapiens UbiA prenyltransferase domain containing 1 (UBIAD1), mRNA.	43					menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(3)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		GCGCTCCTGGAGGCAGAAGTG	0.622000														13			8		0	0	5.18039e-06	0	0
GHR	2690	broad.mit.edu	37	5	42718721	42718721	+	Missense_Mutation	SNP	A	C	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:42718721A>C	uc021xxv.1	+	9	1270	c.1133A>C	c.(1132-1134)gAg>gCg	p.E378A	GHR_uc003jmt.3_Missense_Mutation_p.E371A|GHR_uc003jmu.3_Missense_Mutation_p.E371A|GHR_uc003jmv.2_Missense_Mutation_p.E371A|GHR_uc021xxw.1_Missense_Mutation_p.E371A|GHR_uc021xxx.1_Missense_Mutation_p.E371A|GHR_uc021xxy.1_Missense_Mutation_p.E371A|GHR_uc021xxz.1_Missense_Mutation_p.E371A|GHR_uc021xya.1_Missense_Mutation_p.E371A|GHR_uc021xyb.1_3'UTR|GHR_uc021xyc.1_3'UTR|GHR_uc011cpq.2_Missense_Mutation_p.E184A|GHR_uc021xyd.1_Missense_Mutation_p.E349A	NM_001242399	NP_001229328	P10912	GHR_HUMAN	Homo sapiens growth hormone receptor (GHR), transcript variant 2, mRNA.	371					2-oxoglutarate metabolic process|JAK-STAT cascade|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AGTGACCATGAGAAATCACAT	0.433000														6			36		0	0	7.24521e-05	0	0
FKBP9	11328	broad.mit.edu	37	7	33042361	33042361	+	Silent	SNP	G	A	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr7:33042361G>A	uc011kal.2	+	9	1786	c.1605G>A	c.(1603-1605)gaG>gaA	p.E535E	AVL9_uc011kai.2_Intron|FKBP9_uc011kak.1_Non-coding_Transcript|FKBP9_uc003tdh.3_Silent_p.E482E|FKBP9_uc011kam.2_Silent_p.E250E|U6_uc022abn.1_5'Flank	NM_007270	NP_009201	O95302	FKBP9_HUMAN	Homo sapiens FK506 binding protein 9, 63 kDa (FKBP9), mRNA.	482	EF-hand 2.				protein folding	endoplasmic reticulum|membrane	FK506 binding|calcium ion binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			GCCTTCCTGAGGGGTACATGT	0.532000														3			16		0	0	3.45872e-05	0	0
ZBTB1	22890	broad.mit.edu	37	14	64988483	64988483	+	Silent	SNP	T	A	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr14:64988483T>A	uc021rul.1	+	0	261	c.261T>A	c.(259-261)atT>atA	p.I87I	ZBTB1_uc001xhh.4_Silent_p.I87I|ZBTB1_uc010aqg.3_Silent_p.I87I|ZBTB1_uc001xhi.2_Silent_p.I87I|ZBTB1_uc021rum.1_5'Flank	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	Homo sapiens zinc finger and BTB domain containing 1 (ZBTB1), transcript variant 1, mRNA.	87	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	13		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		TAGGAAAAATTATGACAGCTC	0.373000														43			22		0	0	2.27731e-05	0	0
CXXC1	30827	broad.mit.edu	37	18	47812187	47812187	+	Nonsense_Mutation	SNP	T	A	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr18:47812187T>A	uc002leq.4	-	4	1304	c.571A>T	c.(571-573)Aag>Tag	p.K191*	CXXC1_uc002lep.4_Nonsense_Mutation_p.K48*|CXXC1_uc002ler.4_Nonsense_Mutation_p.K191*|CXXC1_uc010doy.3_Nonsense_Mutation_p.K191*	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	Homo sapiens CXXC finger protein 1 (CXXC1), transcript variant 2, mRNA.	191					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	Set1C/COMPASS complex|nuclear speck	protein binding|unmethylated CpG binding|zinc ion binding	p.M190I(1)		autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						CCGAACTTCTTCATGTCCCGA	0.622000														18			15		0	0	5.01169e-05	0	0
L3MBTL4	91133	broad.mit.edu	37	18	5969390	5969390	+	Splice_Site	SNP	A	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr18:5969390A>G	uc002kmz.4	-	18	1801	c.1641_splice	c.e18+1	p.E547_splice	L3MBTL4_uc002kmy.4_Splice_Site_p.E538_splice|L3MBTL4_uc010dkt.3_Splice_Site_p.E547_splice	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	Homo sapiens l(3)mbt-like 4 (Drosophila) (L3MBTL4), mRNA.	547	SAM.				chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				AGCTCCACTCACCTCATCCAC	0.622000														37			4		0	0	3.59834e-05	0	0
TMEM86B	255043	broad.mit.edu	37	19	55739565	55739565	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr19:55739565C>T	uc002qju.3	-	1	815	c.292G>A	c.(292-294)Gtc>Atc	p.V98I	TMEM86B_uc002qjt.3_Missense_Mutation_p.V97I	NM_173804	NP_776165	Q8N661	TM86B_HUMAN	Homo sapiens transmembrane protein 86B (TMEM86B), mRNA.	98					ether lipid metabolic process	cytoplasmic part|integral to membrane	alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity			skin(2)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		TCACCAGGGACGAAGGCTGCC	0.652000														8			8		0	0	2.17888e-05	0	0
CROCCP2	84809	broad.mit.edu	37	1	16952952	16952952	+	RNA	SNP	G	A	A	rs1762946	by1000genomes	TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:16952952G>A	uc010ocf.2	-	0		c.43C>T			CROCCP2_uc009vov.2_Non-coding_Transcript|CROCCP2_uc001aze.3_Non-coding_Transcript|CROCCP2_uc001azf.3_Non-coding_Transcript|CROCCP2_uc001azg.1_Non-coding_Transcript					Homo sapiens ciliary rootlet coiled-coil, rootletin pseudogene 2 (CROCCP2), non-coding RNA.																		TCTGCCCTCAGCTTGGTCACG	0.622000														18			5		0	0	1.23904e-05	0	0
MST1P2	11209	broad.mit.edu	37	1	16974511	16974511	+	RNA	SNP	G	A	A	rs58679574	by1000genomes	TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:16974511G>A	uc009vow.2	+	4		c.1321G>A			MST1P2_uc010ocg.1_Non-coding_Transcript|MST1P2_uc010och.2_Non-coding_Transcript|MST1P2_uc010oci.1_Non-coding_Transcript|MST1P2_uc001azk.2_Non-coding_Transcript|MST1P2_uc009vox.3_Non-coding_Transcript|MST1P2_uc001azm.4_Non-coding_Transcript					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 2 (MST1P2), non-coding RNA.																		GGGTAGTCACGGGCTTAGGGC	0.652000														18			5		0	0	1.23904e-05	0	0
GLP1R	2740	broad.mit.edu	37	6	39041404	39041404	+	Silent	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr6:39041404C>T	uc003ooj.4	+	6	742	c.682C>T	c.(682-684)Ctg>Ttg	p.L228L	GLP1R_uc003ooh.2_Non-coding_Transcript|GLP1R_uc003ooi.2_Non-coding_Transcript	NM_002062	NP_002053	P43220	GLP1R_HUMAN	Homo sapiens glucagon-like peptide 1 receptor (GLP1R), mRNA.	228					activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			breast(5)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	31					Exenatide(DB01276)|Glucagon recombinant(DB00040)	GAGCTGCCGCCTGGTGTTTCT	0.587000														34			26		0	0	0.000147802	0	0
GPX7	2882	broad.mit.edu	37	1	53072382	53072382	+	Silent	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:53072382C>T	uc001cue.3	+	1	204	c.165C>T	c.(163-165)agC>agT	p.S55S		NM_015696	NP_056511	Q96SL4	GPX7_HUMAN	Homo sapiens glutathione peroxidase 7 (GPX7), mRNA.	55					response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	ATGTGGCCAGCGAGTGCGGCT	0.572000														8			11		0	0	6.40141e-05	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74625601	74625601	+	Silent	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr17:74625601C>T	uc002jsh.3	-	1	498	c.324G>A	c.(322-324)ccG>ccA	p.P108P	ST6GALNAC1_uc002jsi.3_5'UTR|ST6GALNAC1_uc002jsj.3_Non-coding_Transcript	NM_018414	NP_060884	Q9NSC7	SIA7A_HUMAN	Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1), mRNA.	108					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						GCTCCTCCGGCGGTGCCTGGT	0.587000														16			15		0	0	1.49906e-05	0	0
LMOD1	25802	broad.mit.edu	37	1	201868801	201868802	+	Missense_Mutation	DNP	AG	CT	CT			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:201868801_201868802AG>CT	uc021phl.1	-	1	1587_1588	c.1339_1340CT>AG	c.(1339-1341)ctg>AGg	p.L447R	LMOD1_uc021phm.1_Missense_Mutation_p.L447R|LMOD1_uc010ppu.2_Missense_Mutation_p.L396R	NM_012134	NP_036266	P29536	LMOD1_HUMAN	Homo sapiens leiomodin 1 (smooth muscle) (LMOD1), mRNA.	447					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CAGCTTGAGCAGGGTAGTATTC	0.569000														6			5		0	0	6.4e-05	0	0
NLRP10	338322	broad.mit.edu	37	11	7982724	7982724	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr11:7982724C>A	uc001mfv.1	-	1	452	c.435G>T	c.(433-435)caG>caT	p.Q145H		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	Homo sapiens NLR family, pyrin domain containing 10 (NLRP10), mRNA.	145							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACTCCAGCTCCTGCTCCGGGA	0.592000														18			16		2.31682e-05	0.00179151	2.31682e-05	1	0
DMD	1756	broad.mit.edu	37	X	32486764	32486764	+	Missense_Mutation	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chrX:32486764C>T	uc004dda.1	-	22	3257	c.3013G>A	c.(3013-3015)Gag>Aag	p.E1005K	DMD_uc004dcz.2_Missense_Mutation_p.E882K|DMD_uc004dcy.1_Missense_Mutation_p.E1001K|DMD_uc004ddb.1_Missense_Mutation_p.E997K|DMD_uc010ngo.1_Intron	NM_004006	NP_004001	P11532	DMD_HUMAN	Homo sapiens dystrophin (DMD), transcript variant Dp427m, mRNA.	1005					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTCGACATCTCTTTCACAGTG	0.403000														4			22		0	0	4.16121e-05	0	0
PDHX	8050	broad.mit.edu	37	11	34991758	34991758	+	Missense_Mutation	SNP	A	C	C	rs146262415		TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr11:34991758A>C	uc001mvt.3	+	6	1415	c.889A>C	c.(889-891)Act>Cct	p.T297P	PDHX_uc010rep.2_Missense_Mutation_p.T282P|PDHX_uc010req.2_Intron	NM_003477	NP_003468	O00330	ODPX_HUMAN	Homo sapiens pyruvate dehydrogenase complex, component X (PDHX), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	297					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	16	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			ATCTAAAAGTACTGTACCTCA	0.393000														24			13		0	0	1.49906e-05	0	0
C9orf84	158401	broad.mit.edu	37	9	114456569	114456569	+	Nonsense_Mutation	SNP	G	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr9:114456569G>T	uc004bfr.3	-	22	3200	c.3065C>A	c.(3064-3066)tCa>tAa	p.S1022*	C9orf84_uc011lwt.2_Non-coding_Transcript|C9orf84_uc004bfq.3_Nonsense_Mutation_p.S983*|C9orf84_uc010mug.3_Nonsense_Mutation_p.S933*	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	Homo sapiens chromosome 9 open reading frame 84 (C9orf84), transcript variant 1, mRNA.	1022										breast(1)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(10)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						ATCTCTCTTTGAGGTCATTAA	0.328000														232			9		6.40141e-05	0.0046469	6.40141e-05	1	0
ATRN	8455	broad.mit.edu	37	20	3515900	3515900	+	Splice_Site	SNP	A	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr20:3515900A>G	uc002wim.2	+	2	501	c.411_splice	c.e2-1	p.R137_splice	ATRN_uc002wil.2_Splice_Site_p.R137_splice|ATRN_uc021vzz.1_Splice_Site_p.R21_splice	NM_139321	NP_647537	O75882	ATRN_HUMAN	Homo sapiens attractin (ATRN), transcript variant 1, mRNA.	137	CUB.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						TAAATTACAGACTAACTGGAT	0.279000														35			21		0	0	2.27731e-05	0	0
ADCY2	108	broad.mit.edu	37	5	7789862	7789862	+	Silent	SNP	G	A	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:7789862G>A	uc003jdz.1	+	19	2644	c.2577G>A	c.(2575-2577)gtG>gtA	p.V859V	ADCY2_uc011cmo.1_Silent_p.V679V|ADCY2_uc010itm.1_Silent_p.V55V	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	Homo sapiens adenylate cyclase 2 (brain) (ADCY2), mRNA.	859					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding	p.N858N(2)		NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TGGAGAACGTGCTTCCCGCGC	0.562000														62			11		0	0	3.86212e-05	0	0
GRIPAP1	56850	broad.mit.edu	37	X	48847416	48847416	+	Silent	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chrX:48847416C>T	uc004dly.1	-	6	599	c.564G>A	c.(562-564)ccG>ccA	p.P188P	GRIPAP1_uc004dlz.3_Silent_p.P78P|GRIPAP1_uc004dma.3_Silent_p.P135P	NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	Homo sapiens GRIP1 associated protein 1 (GRIPAP1), transcript variant 1, mRNA.	188						early endosome		p.P135P(2)|p.P188P(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(2)	10						CCTCTGCCAACGGCATGGGGG	0.597000														4			14		0	0	2.31682e-05	0	0
HCFC1	3054	broad.mit.edu	37	X	153227717	153227717	+	Silent	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chrX:153227717C>T	uc004fjp.3	-	4	1281	c.753G>A	c.(751-753)gcG>gcA	p.A251A		NM_005334	NP_005325	P51610	HCFC1_HUMAN	Homo sapiens host cell factor C1 (VP16-accessory protein) (HCFC1), mRNA.	251					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex|MLL5-L complex|Set1C/COMPASS complex|mitochondrion	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GAGGAAGAGGCGCCACCCCGC	0.597000														9			8		0	0	3.86212e-05	0	0
FER1L6	654463	broad.mit.edu	37	8	125035704	125035704	+	Silent	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr8:125035704C>T	uc003yqw.3	+	17	2360	c.2154C>T	c.(2152-2154)gaC>gaT	p.D718D	FER1L6-AS1_uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	Homo sapiens fer-1-like 6 (C. elegans) (FER1L6), mRNA.	718						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTATCCCTGACGTTTTCATCT	0.527000														31			18		0	0	3.10358e-05	0	0
MST1P9	11223	broad.mit.edu	37	1	17084021	17084021	+	Missense_Mutation	SNP	C	G	G	rs2446543		TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:17084021C>G	uc010ock.2	-	13	1900	c.1900G>C	c.(1900-1902)Gcc>Ccc	p.A634P	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.4_Missense_Mutation_p.A234P					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 9 (MST1P9), non-coding RNA.									p.A634P(1)		breast(1)|endometrium(11)|kidney(9)|large_intestine(1)|lung(5)|pancreas(1)|prostate(4)|stomach(1)|urinary_tract(1)	34						ACCTCACAGGCCCCCACAGGG	0.572000														28			5		0	0	5.18039e-06	0	0
PRKDC	5591	broad.mit.edu	37	8	48840367	48840367	+	Silent	SNP	A	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr8:48840367A>G	uc003xqi.3	-	19	2280	c.2223T>C	c.(2221-2223)atT>atC	p.I741I	PRKDC_uc003xqj.3_Silent_p.I741I	NM_006904	NP_008835	P78527	PRKDC_HUMAN	Homo sapiens protein kinase, DNA-activated, catalytic polypeptide (PRKDC), transcript variant 1, mRNA.	741					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CATCGAGTTCAATGATGTTGT	0.443000								Non-homologous end-joining						16			9		0	0	2.17888e-05	0	0
PIGU	128869	broad.mit.edu	37	20	33176297	33176297	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr20:33176297G>C	uc002xas.3	-	7	942	c.742C>G	c.(742-744)Ctc>Gtc	p.L248V	PIGU_uc010zul.2_Missense_Mutation_p.L248V|PIGU_uc002xat.3_Missense_Mutation_p.L228V|PIGU_uc010gev.1_Non-coding_Transcript	NM_080476	NP_536724	Q9H490	PIGU_HUMAN	Homo sapiens phosphatidylinositol glycan anchor biosynthesis, class U (PIGU), mRNA.	248					C-terminal protein lipidation|attachment of GPI anchor to protein|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						CAAGAGCTGAGAAGGAAGAAG	0.433000														15			10		0	0	6.40141e-05	0	0
APC	324	broad.mit.edu	37	5	112173801	112173801	+	Nonsense_Mutation	SNP	C	G	G	rs79512956		TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:112173801C>G	uc003kpz.4	+	16	2703	c.2510C>G	c.(2509-2511)tCa>tGa	p.S837*	APC_uc011cvt.2_Nonsense_Mutation_p.S819*|APC_uc003kpy.4_Nonsense_Mutation_p.S837*|APC_uc010jbz.3_Nonsense_Mutation_p.S554*|APC_uc010jca.3_Nonsense_Mutation_p.S137*	NM_001127510	NP_001120982	P25054	APC_HUMAN	Homo sapiens adenomatous polyposis coli (APC), transcript variant 2, mRNA.	837	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|adherens junction|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)|p.S837fs*7(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCCTCTTCATCAAGAGGAAGC	0.398000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)				22			22		0	0	2.27731e-05	0	0
CYLC2	1539	broad.mit.edu	37	9	105765476	105765476	+	Silent	SNP	T	C	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr9:105765476T>C	uc004bbs.2	+	2	181	c.111T>C	c.(109-111)ttT>ttC	p.F37F		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	Homo sapiens cylicin, basic protein of sperm head cytoskeleton 2 (CYLC2), mRNA.	37	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				CCCTGTTATTTCCCAAACCAC	0.368000														40			16		0	0	9.7654e-05	0	0
CAPNS1	826	broad.mit.edu	37	19	36640548	36640548	+	Missense_Mutation	SNP	C	G	G			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr19:36640548C>G	uc002odi.1	+	9	947	c.790C>G	c.(790-792)Ccc>Gcc	p.P264A	CAPNS1_uc002odk.3_Intron|CAPNS1_uc002odj.3_Intron|CAPNS1_uc002odl.3_Intron	NM_001749	NP_001740	P04632	CPNS1_HUMAN	Homo sapiens calpain, small subunit 1 (CAPNS1), transcript variant 1, mRNA.	0	EF-hand 5.			WLQLTMYS -> VRTPILGYGCLGGPHPSALHTSSELQSPS SYFASRPWVRAKGLVLLGFPVLTLHPPLPSGCS (in Ref. 7; AAH11903).	positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGTAAGGACCCCCATATTGGG	0.572000														9			8		0	0	5.18039e-06	0	0
FAM83B	222584	broad.mit.edu	37	6	54805115	54805115	+	Missense_Mutation	SNP	C	T	T	rs147775708	byFrequency	TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr6:54805115C>T	uc003pck.3	+	4	1462	c.1346C>T	c.(1345-1347)gCg>gTg	p.A449V		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	Homo sapiens family with sequence similarity 83, member B (FAM83B), mRNA.	449										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AATCGGCTTGCGCAGAGAAAA	0.463000														29			12		0	0	0.00010058	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604055	140604055	+	Silent	SNP	T	C	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:140604055T>C	uc003ljb.3	+	0	978	c.978T>C	c.(976-978)ggT>ggC	p.G326G		NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	Homo sapiens protocadherin beta 14 (PCDHB14), mRNA.	326	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGGTGGGGGTCTTTCAGGAA	0.383000														47			6		0	0	3.59834e-05	0	0
IQGAP2	10788	broad.mit.edu	37	5	75970327	75970327	+	Missense_Mutation	SNP	G	C	C			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr5:75970327G>C	uc003kek.3	+	26	3542	c.3320G>C	c.(3319-3321)cGg>cCg	p.R1107P	IQGAP2_uc011csv.2_Missense_Mutation_p.R603P|IQGAP2_uc003kel.3_Missense_Mutation_p.R603P|IQGAP2_uc010izw.1_5'UTR	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	Homo sapiens IQ motif containing GTPase activating protein 2 (IQGAP2), mRNA.	1107	Ras-GAP.				small GTPase mediated signal transduction	actin cytoskeleton	GTPase inhibitor activity|Ras GTPase activator activity|actin binding|calmodulin binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		CTGTACTATCGGTACATGAAT	0.388000														41			4		0	0	8.12818e-05	0	0
MBD5	55777	broad.mit.edu	37	2	149247828	149247828	+	Nonsense_Mutation	SNP	C	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr2:149247828C>T	uc002twm.4	+	11	4925	c.3928C>T	c.(3928-3930)Caa>Taa	p.Q1310*	MBD5_uc010zbs.2_Intron|MBD5_uc002two.3_Nonsense_Mutation_p.Q568*|MBD5_uc002twp.3_Nonsense_Mutation_p.Q360*	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	Homo sapiens methyl-CpG binding domain protein 5 (MBD5), mRNA.	1310						chromosome|nucleus	DNA binding|chromatin binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		CACTGCAAAGCAAGACCTGGT	0.443000														25			21		0	0	2.27731e-05	0	0
HYI	81888	broad.mit.edu	37	1	43917105	43917105	+	Missense_Mutation	SNP	C	A	A			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:43917105C>A	uc001cjo.3	-	6	932	c.736G>T	c.(736-738)Gtg>Ttg	p.V246L	SZT2_uc001cjk.2_3'UTR|SZT2_uc001cjl.2_3'UTR|HYI_uc021omp.1_Missense_Mutation_p.V173L|HYI_uc001cjm.3_Missense_Mutation_p.V173L|HYI_uc021omq.1_Missense_Mutation_p.V271L|HYI_uc001cjn.3_Missense_Mutation_p.V246L	NM_001190880	NP_001177809	Q5T013	HYI_HUMAN	Homo sapiens hydroxypyruvate isomerase (putative) (HYI), transcript variant 3, mRNA.	246							hydroxypyruvate isomerase activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	6	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCACAGCCCACGAAGCCTTTG	0.622000														21			17		9.16793e-09	7.24674e-07	5.01169e-05	1	0
PLA2G2F	64600	broad.mit.edu	37	1	20465966	20465967	+	Frame_Shift_Del	DEL	GT	-	-			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr1:20465966_20465967delGT	uc009vpp.1	+	0	144_145	c.46_47delGT	c.(46-48)gtgfs	p.V16fs		NM_022819	NP_073730	Q9BZM2	PA2GF_HUMAN	Homo sapiens phospholipase A2, group IIF (PLA2G2F), mRNA.	0					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	15		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CAAAAAGAAGGTGCTGGATAGA	0.579													---	4	---	---	2	---					
HECTD1	25831	broad.mit.edu	37	14	31602754	31602755	+	Frame_Shift_Ins	INS	-	T	T			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr14:31602754_31602755insT	uc001wrc.1	-	22	4194_4195	c.3705_3706insA	c.(3703-3708)gaacttfs	p.E1235fs	HECTD1_uc001wrd.1_Frame_Shift_Ins_p.E750fs	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	Homo sapiens HECT domain containing 1 (HECTD1), mRNA.	1235					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GTGCCATAAAGTTCGAATCCAG	0.376													---	56	---	---	45	---					
HERC1	8925	broad.mit.edu	37	15	64039192	64039192	+	Frame_Shift_Del	DEL	G	-	-			TCGA-FS-A1ZG-06A-11D-A197-08	TCGA-FS-A1ZG-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	12d3df2b-80aa-46ac-8a04-e7b0e9c45ff2	98ec11e7-b2e4-4c0f-9821-2440389ef54e	g.chr15:64039192delG	uc002amp.3	-	11	2593	c.2445delC	c.(2443-2445)ctcfs	p.L815fs	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	Homo sapiens hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 (HERC1), mRNA.	815					protein modification process|transport	Golgi apparatus|cytosol|membrane	ARF guanyl-nucleotide exchange factor activity|acid-amino acid ligase activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CCTGCCTCCCGAGAATGCTGG	0.478													---	4	---	---	2	---