Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CCDC63	160762	broad.mit.edu	37	12	111336859	111336859	+	Silent	SNP	C	T	T	rs115748204	by1000genomes	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr12:111336859C>T	uc001trv.1	+	9	1467	c.1272C>T	c.(1270-1272)gaC>gaT	p.D424D	CCDC63_uc010sye.1_Silent_p.D384D|CCDC63_uc001trw.1_Silent_p.D339D	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	Homo sapiens coiled-coil domain containing 63 (CCDC63), mRNA.	424										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						TAAACTGTGACGCCACCAAGA	0.498000														15			11		0	0	1	0	0
LOC440518	440518	broad.mit.edu	37	19	22785310	22785310	+	RNA	SNP	A	G	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:22785310A>G	uc002nqu.4	+	6		c.1486A>G								Homo sapiens golgin A2 pseudogene (LOC440518), non-coding RNA.																		GCCATGGAGAAACTGCAGGTG	0.627000														5			10		0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471145	92471145	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:92471145G>C	uc001xzy.3	-	10	3549	c.3175C>G	c.(3175-3177)Cag>Gag	p.Q1059E	TRIP11_uc010auf.2_Missense_Mutation_p.Q795E	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.	1059					transcription from RNA polymerase II promoter	Golgi apparatus|cytoskeleton|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TGAATAATCTGAGTTAGTTTA	0.338000			T	PDGFRB	AML									39			8		0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8526635	8526635	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr9:8526635G>T	uc003zkk.3	-	16	1303	c.560C>A	c.(559-561)cCa>cAa	p.P187Q	PTPRD_uc003zkp.3_Missense_Mutation_p.P187Q|PTPRD_uc003zkq.3_Missense_Mutation_p.P187Q|PTPRD_uc003zkr.3_Intron|PTPRD_uc003zks.3_Intron|PTPRD_uc022bdj.1_Missense_Mutation_p.P184Q	NM_002839	NP_002830	P23468	PTPRD_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant 1, mRNA.	187	Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACCTCTTATTGGTGTACCACC	0.398000										TSP Lung(15;0.13)				37			8		1.12685e-05	1.35999e-05	1	1	0
GLB1L2	89944	broad.mit.edu	37	11	134244581	134244581	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr11:134244581C>A	uc001qhp.3	+	17	1981	c.1793C>A	c.(1792-1794)cCa>cAa	p.P598Q	GLB1L2_uc009zdg.1_Non-coding_Transcript	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	Homo sapiens galactosidase, beta 1-like 2 (GLB1L2), mRNA.	598					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CTTTACCTCCCAGGTCCCTGG	0.597000														67			7		0.0293803	0.0305439	1	1	0
SLC9C2	284525	broad.mit.edu	37	1	173551109	173551109	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:173551109C>A	uc001giz.2	-	6	1102	c.679G>T	c.(679-681)Gga>Tga	p.G227*	SLC9C2_uc010pmq.1_Non-coding_Transcript	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	Homo sapiens solute carrier family 9, member 11 (SLC9A11), mRNA.	227					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										ATTATGCTTCCCAAAATGTCA	0.299000														12			5		0.000602214	0.000679919	1	1	0
BAG6	7917	broad.mit.edu	37	6	31606981	31606981	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:31606981C>T	uc003nvg.4	-	24	3640	c.3326G>A	c.(3325-3327)cGa>cAa	p.R1109Q	BAG6_uc003nvf.4_Missense_Mutation_p.R1103Q|BAG6_uc003nvi.4_Missense_Mutation_p.R1103Q|BAG6_uc003nvh.4_Missense_Mutation_p.R1103Q|BAG6_uc011dnw.2_Missense_Mutation_p.R1054Q|BAG6_uc011dnx.2_Missense_Mutation_p.R880Q	NM_004639	NP_004630	P46379	BAG6_HUMAN	Homo sapiens BCL2-associated athanogene 6 (BAG6), transcript variant 1, mRNA.	1109					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						TTCCTGCAGTCGTTTTTGTAT	0.532000														12			10		0	0	1	0	0
LILRB4	11006	broad.mit.edu	37	19	55175308	55175308	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:55175308G>T	uc002qgp.3	+	2	529	c.167G>T	c.(166-168)cGg>cTg	p.R56L	LILRB4_uc002qgo.1_Missense_Mutation_p.R97L|LILRB4_uc002qgq.3_Missense_Mutation_p.R56L|LILRB4_uc010ers.1_5'UTR|LILRB4_uc010ert.3_Missense_Mutation_p.R97L|LILRB4_uc010eru.3_Missense_Mutation_p.R85L	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 (LILRB4), transcript variant 1, mRNA.	56	Ig-like C2-type 1.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		CTGGAGGCTCGGGAGTACCGT	0.607000														151			25		9.86323e-18	1.39951e-17	1	1	0
FCGBP	8857	broad.mit.edu	37	19	40368357	40368357	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:40368357C>T	uc002omp.4	-	27	12999	c.12991G>A	c.(12991-12993)Gcc>Acc	p.A4331T		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Homo sapiens Fc fragment of IgG binding protein (FCGBP), mRNA.	4331						extracellular region	protein binding	p.A4331T(2)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCTGGCAGGCGGCCACGTAG	0.647000														149			17		0	0	1	0	0
SPDEF	25803	broad.mit.edu	37	6	34511922	34511922	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:34511922C>T	uc003ojq.2	-	1	745	c.311G>A	c.(310-312)aGc>aAc	p.S104N	SPDEF_uc011dsq.2_Missense_Mutation_p.S104N	NM_012391	NP_036523	O95238	SPDEF_HUMAN	Homo sapiens SAM pointed domain containing ets transcription factor (SPDEF), transcript variant 1, mRNA.	104					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)	15						CAAGTCCAGGCTGCCCGCTGG	0.682000														22			20		0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359169	66359169	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr11:66359169C>T	uc001oiq.4	-	0	1386	c.1318G>A	c.(1318-1320)Gtg>Atg	p.V440M	CCS_uc001oir.3_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	Homo sapiens coiled-coil domain containing 87 (CCDC87), mRNA.	440										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GCCTGGACCACGACCTCATTT	0.552000														57			34		0	0	1	0	0
ZBED2	79413	broad.mit.edu	37	3	111312564	111312564	+	Missense_Mutation	SNP	C	A	A	rs144259563	byFrequency	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:111312564C>A	uc003dxy.3	-	1	1386	c.485G>T	c.(484-486)aGg>aTg	p.R162M	CD96_uc003dxv.3_Intron|CD96_uc003dxw.3_Intron|CD96_uc003dxx.3_Intron|CD96_uc010hpy.1_Intron|ZBED2_uc021xci.1_Missense_Mutation_p.R162M	NM_024508	NP_078784	Q9BTP6	ZBED2_HUMAN	Homo sapiens zinc finger, BED-type containing 2 (ZBED2), mRNA.	162							DNA binding|metal ion binding			large_intestine(3)|lung(1)|skin(2)	6						CCTTTCCCTCCTAAGCACCTC	0.607000														46			15		0.00498961	0.00534601	1	1	0
FAM161A	84140	broad.mit.edu	37	2	62054287	62054287	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:62054287T>C	uc002sbm.4	-	5	2060	c.1958A>G	c.(1957-1959)gAg>gGg	p.E653G	FAM161A_uc002sbn.4_Missense_Mutation_p.E407G|FAM161A_uc010ypo.2_Missense_Mutation_p.E597G|FAM161A_uc010fcm.1_Non-coding_Transcript	NM_001201543	NP_001188472	Q3B820	F161A_HUMAN	Homo sapiens family with sequence similarity 161, member A (FAM161A), transcript variant 1, mRNA.	597	Glu-rich.				response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GTTGAAGTACTCAAGTACTTT	0.348000														36			15		0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78211484	78211484	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr15:78211484C>T	uc010bky.2	-	10	1047	c.283G>A	c.(283-285)Gag>Aag	p.E95K						Homo sapiens golgi autoantigen, golgin subfamily a, 6 pseudogene (LOC645752), non-coding RNA.																		TCCTCCTGCTCCTGGAGTCTC	0.587000														44			56		0	0	1	0	0
KIR2DL2	3803	broad.mit.edu	37	GL000209.1	118633	118633	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chrGL000209.1:118633G>C	uc010yie.2	+	2	121	c.110G>C	c.(109-111)cGc>cCc	p.R37P	KIR2DL2_uc021vdc.1_Intron|KIR2DL2_uc021vdd.1_Intron|KIR2DL2_uc002qty.3_Missense_Mutation_p.R34P|KIR2DL2_uc002qum.3_Missense_Mutation_p.R37P	NM_014512	NP_055327	P43627	KI2L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 (KIR2DS1), mRNA.	37			R -> P (in dbSNP:rs613240).		regulation of immune response	integral to membrane|plasma membrane	receptor activity										CACCCAGGTCGCCTGGTGAAA	0.488000														166			5		0	0	1	0	0
PAF1	54623	broad.mit.edu	37	19	39877178	39877178	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:39877178G>A	uc002old.3	-	12	1302	c.1127C>T	c.(1126-1128)cCg>cTg	p.P376L	PAF1_uc010xuv.2_Non-coding_Transcript|PAF1_uc002ole.1_Missense_Mutation_p.P366L	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Homo sapiens Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) (PAF1), mRNA.	376	Glu-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|urinary_tract(2)	17	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			ttcctcctccGGTTCGTGGTT	0.572000														21			10		0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61607554	61607554	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr17:61607554C>T	uc002jay.3	+	2	490	c.410C>T	c.(409-411)gCc>gTc	p.A137V	KCNH6_uc002jax.1_Missense_Mutation_p.A137V|KCNH6_uc010wpl.2_Missense_Mutation_p.A14V|KCNH6_uc010wpm.2_Missense_Mutation_p.A137V|KCNH6_uc002jaz.1_Missense_Mutation_p.A137V	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 6 (KCNH6), transcript variant 1, mRNA.	137	PAC.				regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CAGCTCCTGGCCAAGTGCAGC	0.627000														75			9		0	0	1	0	0
PICK1	9463	broad.mit.edu	37	22	38471101	38471101	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr22:38471101G>T	uc003auq.3	+	12	1600	c.1210G>T	c.(1210-1212)Ggg>Tgg	p.G404W	PICK1_uc003aur.3_Missense_Mutation_p.G404W|PICK1_uc003aus.3_Missense_Mutation_p.G404W|PICK1_uc003aut.3_Missense_Mutation_p.G404W	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	Homo sapiens protein interacting with PRKCA 1 (PICK1), transcript variant 1, mRNA.	404					DNA methylation involved in embryo development|DNA methylation involved in gamete generation|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	Golgi apparatus|cell junction|endocytic vesicle membrane|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					AGGGGCTGCTGGGCCCTTGGA	0.682000														28			7		0.000274275	0.000313031	1	1	0
NMBR	4829	broad.mit.edu	37	6	142396893	142396893	+	Silent	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:142396893G>T	uc003qiu.3	-	2	1206	c.1065C>A	c.(1063-1065)ctC>ctA	p.L355L		NM_002511	NP_002502	P28336	NMBR_HUMAN	Homo sapiens neuromedin B receptor (NMBR), mRNA.	355					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		CTGAAGAGCTGAGTAGGTAGC	0.463000														74			4		1.23904e-05	1.46179e-05	1	1	0
TMEM190	147744	broad.mit.edu	37	19	55889022	55889022	+	Silent	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:55889022C>A	uc002qkt.1	+	2	174	c.156C>A	c.(154-156)ccC>ccA	p.P52P		NM_139172	NP_631911	Q8WZ59	TM190_HUMAN	Homo sapiens transmembrane protein 190 (TMEM190), mRNA.	52	P-type.					integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		TCGATAGCCCCAACCTCTGCC	0.672000														153			30		7.26314e-15	1.01684e-14	1	1	0
AP1S2	8905	broad.mit.edu	37	17	58180043	58180043	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr17:58180043C>G	uc010wot.1	-	0	238	c.122G>C	c.(121-123)cGc>cCc	p.R41P		NM_003916	NP_003907	P56377	AP1S2_HUMAN	Homo sapiens adaptor-related protein complex 1, sigma 2 subunit (AP1S2), mRNA.	0					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	AP-type membrane coat adaptor complex|Golgi membrane|coated pit|cytoplasmic vesicle membrane|cytosol|lysosomal membrane	protein transporter activity			large_intestine(1)	1	Hepatocellular(33;0.183)					gggccgcgggcgcggcggAGC	0.637000														0			12		0	0	1	0	0
FRG1	2483	broad.mit.edu	37	4	190883067	190883067	+	Silent	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr4:190883067G>A	uc003izs.3	+	7	911	c.720G>A	c.(718-720)ttG>ttA	p.L240L		NM_004477	NP_004468	Q14331	FRG1_HUMAN	Homo sapiens FSHD region gene 1 (FRG1), mRNA.	240					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		ATGGATTTTTGCATGAGACGC	0.323000														89			4		0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109716420	109716420	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:109716420G>A	uc021orb.1	+	6	1134	c.913G>A	c.(913-915)Gaa>Aaa	p.E305K	KIAA1324_uc009wex.2_Intron|KIAA1324_uc010ovg.2_Missense_Mutation_p.E203K|KIAA1324_uc009wey.3_Intron	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	Homo sapiens KIAA1324 (KIAA1324), mRNA.	305					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		AAATAAAGGAGAAACTTCTTG	0.478000														36			7		0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102963969	102963969	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:102963969G>C	uc001ylw.2	+	18	4220	c.3994G>C	c.(3994-3996)Gac>Cac	p.D1332H	TECPR2_uc010txx.2_Missense_Mutation_p.D495H	NM_014844	NP_055659	O15040	TCPR2_HUMAN	Homo sapiens tectonin beta-propeller repeat containing 2 (TECPR2), transcript variant 1, mRNA.	1332							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						TCCAAACGGAGACCTCGCCCG	0.672000														18			6		0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11233960	11233960	+	Silent	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:11233960C>A	uc002mqk.4	+	14	2438	c.2251C>A	c.(2251-2253)Cgg>Agg	p.R751R	LDLR_uc010xlk.2_Silent_p.R751R|LDLR_uc010xll.2_Silent_p.R710R|LDLR_uc021upc.1_Silent_p.R630R|LDLR_uc010xln.2_Silent_p.R573R|LDLR_uc010xlo.2_Silent_p.R583R|LDLR_uc010xlm.2_Silent_p.R604R|LDLR_uc021upd.1_Silent_p.R488R	NM_000527	NP_000518	P01130	LDLR_HUMAN	Homo sapiens low density lipoprotein receptor (LDLR), transcript variant 1, mRNA.	751	Clustered O-linked oligosaccharides.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CGACACCTCCCGGCTGCCTGG	0.622000														61			10		1.76689e-08	2.26249e-08	1	1	0
BCKDHB	594	broad.mit.edu	37	6	80910684	80910684	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:80910684C>G	uc003pjd.2	+	6	843	c.776C>G	c.(775-777)cCa>cGa	p.P259R	BCKDHB_uc003pje.2_Missense_Mutation_p.P259R	NM_000056	NP_898871	P21953	ODBB_HUMAN	Homo sapiens branched chain keto acid dehydrogenase E1, beta polypeptide (BCKDHB), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.	259					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		TACAACATCCCACTGTCCCAG	0.423000														50			6		0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410193	159410193	+	Silent	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:159410193G>T	uc010piv.2	+	0	682	c.645G>T	c.(643-645)ctG>ctT	p.L215L	BC038194_uc001fts.4_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily J, member 1 (OR10J1), mRNA.	215					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TCAGTGTGCTGGTGCTTGTTG	0.453000														57			9		1.12685e-05	1.35999e-05	1	1	0
FCRLA	84824	broad.mit.edu	37	1	161681733	161681733	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:161681733C>T	uc001gbe.3	+	4	820	c.578C>T	c.(577-579)cCa>cTa	p.P193L	FCRLA_uc001gbg.3_Missense_Mutation_p.P47L|FCRLA_uc009wup.3_Intron|FCRLA_uc009wuq.3_Intron|FCRLA_uc001gbd.3_Missense_Mutation_p.P187L|FCRLA_uc001gbf.3_Missense_Mutation_p.P98L|FCRLA_uc009wuo.3_Missense_Mutation_p.P53L	NM_001184866	NP_001171795	Q7L513	FCRLA_HUMAN	Homo sapiens Fc receptor-like A (FCRLA), transcript variant 1, mRNA.	170	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region				breast(1)|kidney(12)|large_intestine(4)|lung(13)|prostate(1)|skin(2)|stomach(1)	34	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GAACTGTTTCCAGCGCCAATT	0.517000														100			116		0	0	1	0	0
EP400NL	347918	broad.mit.edu	37	12	132589596	132589596	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr12:132589596C>T	uc001ujv.3	+	0	1055	c.1031C>T	c.(1030-1032)cCc>cTc	p.P344L	EP400NL_uc001ujr.2_Missense_Mutation_p.P212L|EP400NL_uc001ujs.4_Missense_Mutation_p.P275L|EP400NL_uc009zyq.3_Missense_Mutation_p.P212L|EP400NL_uc001ujt.3_Missense_Mutation_p.P212L|EP400NL_uc001ujw.1_Missense_Mutation_p.P43L					Homo sapiens EP400 N-terminal like (EP400NL), non-coding RNA.											endometrium(1)|lung(1)|prostate(2)|urinary_tract(1)	5						GAGGAGATTCCCCCAGCCTCT	0.557000														2			2		0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4967967	4967967	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr11:4967967A>G	uc010qys.2	-	0	364	c.364T>C	c.(364-366)Ttt>Ctt	p.F122L		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily A, member 4 (OR51A4), mRNA.	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S121L(1)		large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AATCTATCAAATGACATGATC	0.438000														120			21		0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453987	140453987	+	Splice_Site	SNP	T	G	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:140453987T>G	uc003vwc.4	-	14	1802	c.1741_splice	c.e14+1	p.N581_splice		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	581	Protein kinase.		N -> D (in CFC syndrome).|N -> S (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GGAAGGATACTATTACTCTTG	0.373000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome					30			31		0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8152717	8152717	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:8152717A>C	uc002mjf.3	-	51	6628	c.6611T>G	c.(6610-6612)aTg>aGg	p.M2204R	FBN3_uc002mje.3_Missense_Mutation_p.M43R	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	Homo sapiens fibrillin 3 (FBN3), mRNA.	2204	EGF-like 35; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						acctcgaCACATGGCCCCATC	0.557000														11			29		0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160977073	160977073	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:160977073C>T	uc003qtl.3	-	30	5077	c.4957G>A	c.(4957-4959)Gaa>Aaa	p.E1653K		NM_005577	NP_005568	P08519	APOA_HUMAN	Homo sapiens lipoprotein, Lp(a) (LPA), mRNA.	4161	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGGTAGTTTTCTGGGGTCCTC	0.458000														38			18		0	0	1	0	0
SAAL1	113174	broad.mit.edu	37	11	18110965	18110965	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr11:18110965G>T	uc001mnq.3	-	6	732	c.682C>A	c.(682-684)Cag>Aag	p.Q228K	SAAL1_uc001mnr.3_Missense_Mutation_p.Q228K	NM_138421	NP_612430	Q96ER3	SAAL1_HUMAN	Homo sapiens serum amyloid A-like 1 (SAAL1), mRNA.	228					acute-phase response	extracellular region	binding			breast(2)|large_intestine(5)|lung(8)	15						TCCAGAGGCTGAGCAGCCCCA	0.512000														39			19		0.000958276	0.00107041	1	1	0
MAGI2	9863	broad.mit.edu	37	7	77885617	77885617	+	Silent	SNP	G	T	T	rs139352828		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:77885617G>T	uc003ugx.3	-	9	1944	c.1690C>A	c.(1690-1692)Cgg>Agg	p.R564R	MAGI2_uc003ugy.3_Silent_p.R564R|MAGI2_uc010ldx.1_Silent_p.R173R|MAGI2_uc010ldy.1_Silent_p.R173R|MAGI2_uc011kgr.1_Silent_p.R396R|MAGI2_uc011kgs.1_Silent_p.R401R	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2), mRNA.	564						cell junction|synapse|synaptosome	phosphatase binding	p.R564Q(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGAGGCGGCCGATCTGTTATA	0.502000														35			6		0.0293803	0.0305439	1	1	0
ADAMDEC1	27299	broad.mit.edu	37	8	24259555	24259555	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr8:24259555G>T	uc003xdz.2	+	11	1490	c.1270G>T	c.(1270-1272)Ggg>Tgg	p.G424W	ADAMDEC1_uc010lub.2_Missense_Mutation_p.G345W|ADAMDEC1_uc011lab.1_Missense_Mutation_p.G345W	NM_014479	NP_001138744	O15204	ADEC1_HUMAN	Homo sapiens ADAM-like, decysin 1 (ADAMDEC1), transcript variant 1, mRNA.	424	Disintegrin.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		ACCAGTGTGTGGGAACCACCT	0.393000														26			3		0.184627	0.188212	1	1	0
XKR6	286046	broad.mit.edu	37	8	10755649	10755649	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr8:10755649G>T	uc003wtk.1	-	2	1766	c.1739C>A	c.(1738-1740)cCa>cAa	p.P580Q		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	Homo sapiens XK, Kell blood group complex subunit-related family, member 6 (XKR6), transcript variant 2, mRNA.	580						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		GGGCCCTTCTGGGAGGTAAGG	0.522000														21			3		0.004672	0.00505732	1	1	0
TRPM2	7226	broad.mit.edu	37	21	45815342	45815342	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr21:45815342C>A	uc010gpt.1	+	11	1940	c.1840C>A	c.(1840-1842)Cat>Aat	p.H614N	TRPM2_uc002zet.1_Missense_Mutation_p.H614N|TRPM2_uc002zeu.1_Missense_Mutation_p.H614N|TRPM2_uc021wjr.1_Non-coding_Transcript|TRPM2_uc002zew.1_Missense_Mutation_p.H614N|TRPM2_uc002zex.1_Missense_Mutation_p.H400N|TRPM2_uc002zey.1_Missense_Mutation_p.H127N	NM_003307	NP_003298	O94759	TRPM2_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1, mRNA.	614						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TTCCTCAGGCCATGTGACCTT	0.597000														107			22		3.83957e-06	4.79946e-06	1	1	0
MAPRE3	22924	broad.mit.edu	37	2	27247084	27247084	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:27247084C>T	uc002rhw.3	+	3	541	c.388C>T	c.(388-390)Cgg>Tgg	p.R130W		NM_012326	NP_036458	Q9UPY8	MARE3_HUMAN	Homo sapiens microtubule-associated protein, RP/EB family, member 3 (MAPRE3), mRNA.	130					cell division|mitosis|positive regulation of transcription, DNA-dependent	cytoplasm|cytoplasmic microtubule|microtubule|midbody|perinuclear region of cytoplasm	microtubule binding|protein binding|small GTPase regulator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|upper_aerodigestive_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGCTGGCGCGGCAGGGCCA	0.473000														26			22		0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91226241	91226241	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:91226241C>G	uc003pnz.1	-	16	2105	c.1800G>C	c.(1798-1800)caG>caC	p.Q600H	MAP3K7_uc003pny.1_Missense_Mutation_p.Q137H|MAP3K7_uc003pob.1_Missense_Mutation_p.Q573H|MAP3K7_uc003poa.1_3'UTR|MAP3K7_uc003poc.1_3'UTR	NM_145331	NP_663304	O43318	M3K7_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant B, mRNA.	600					I-kappaB phosphorylation|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|positive regulation of interleukin-2 production|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|MAP kinase kinase kinase activity|magnesium ion binding|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTTGTCGTTTCTGCTGCTGAC	0.353000														46			22		0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110817227	110817227	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr13:110817227C>T	uc001vqw.4	-	45	4254	c.4132G>A	c.(4132-4134)Ggc>Agc	p.G1378S		NM_001845	NP_001836	P02462	CO4A1_HUMAN	Homo sapiens collagen, type IV, alpha 1 (COL4A1), mRNA.	1378	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTTTCGGGCCTGGCAGTCCC	0.642000														10			4		0	0	1	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806804	97806804	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:97806804G>A	uc011bgs.2	+	0	788	c.788G>A	c.(787-789)cGt>cAt	p.R263H		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily AC, member 2 (OR5AC2), mRNA.	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R263H(2)		endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						ATGTATGTGCGTCCTGCATCT	0.428000														1			15		0	0	1	0	0
ACE2	59272	broad.mit.edu	37	X	15584429	15584429	+	Silent	SNP	T	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chrX:15584429T>A	uc004cxa.1	-	15	2229	c.2061A>T	c.(2059-2061)gcA>gcT	p.A687A	ACE2_uc004cxb.2_Silent_p.A687A	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	Homo sapiens angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), mRNA.	687					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	CATTTTTAGGTGCAGTGACAA	0.398000														6			57		0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21221024	21221024	+	Silent	SNP	C	T	T	rs150656642		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr16:21221024C>T	uc010bwn.1	-	3	457	c.375G>A	c.(373-375)ccG>ccA	p.P125P	ZP2_uc002dii.2_Silent_p.P86P|ZP2_uc010bwo.3_Silent_p.P125P	NM_003460	NP_003451	Q05996	ZP2_HUMAN	Homo sapiens zona pellucida glycoprotein 2 (sperm receptor) (ZP2), mRNA.	86					binding of sperm to zona pellucida|intracellular protein transport	Golgi apparatus|endoplasmic reticulum|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		AAGTGCAGTTCGGCATGTCGA	0.498000														32			25		0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22922632	22922632	+	Silent	SNP	G	T	T	rs144628022		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:22922632G>T	uc001bfx.1	+	8	1856	c.1731G>T	c.(1729-1731)tcG>tcT	p.S577S		NM_020526	NP_065387	P29322	EPHA8_HUMAN	Homo sapiens EPH receptor A8 (EPHA8), transcript variant 1, mRNA.	577						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCCAGGACTCGGACGAGGAGA	0.667000														22			12		5.50884e-06	6.80503e-06	1	1	0
KCNJ4	3761	broad.mit.edu	37	22	38823055	38823055	+	Silent	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr22:38823055C>A	uc003avs.1	-	1	1180	c.1083G>T	c.(1081-1083)ctG>ctT	p.L361L	KCNJ4_uc003avt.1_Silent_p.L361L|KCNJ4_uc021wpp.1_Silent_p.L361L	NM_004981	NP_690607	P48050	IRK4_HUMAN	Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 4 (KCNJ4), transcript variant 2, mRNA.	361					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	PDZ domain binding|inward rectifier potassium channel activity			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					GTGGGGCGGGCAGCACGGTGA	0.642000														62			6		0.0293803	0.0305439	1	1	0
EIF2C2	27161	broad.mit.edu	37	8	141595255	141595255	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr8:141595255C>T	uc003yvn.3	-	1	219	c.178G>A	c.(178-180)Gat>Aat	p.D60N	EIF2C2_uc010meo.3_Missense_Mutation_p.D60N|EIF2C2_uc010men.3_Intron	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	Homo sapiens eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 1, mRNA.	60					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	RNA-induced silencing complex|cytoplasmic mRNA processing body|cytosol|mRNA cap binding complex|micro-ribonucleoprotein complex|nucleus|polysome	RNA 7-methylguanosine cap binding|endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|siRNA binding|translation initiation factor activity			NS(1)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	33	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			GGCTTGATATCCAATTCATAA	0.448000														64			7		0	0	1	0	0
AK302306	0	broad.mit.edu	37	15	28599954	28599954	+	Silent	SNP	A	G	G	rs144345425	by1000genomes	TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr15:28599954A>G	uc010uaf.1	-	3	306	c.288T>C	c.(286-288)ctT>ctC	p.L96L	DQ595648_uc021sgj.1_5'Flank					SubName: Full=Uncharacterized protein; SubName: Full=cDNA FLJ59579, weakly similar to Homo sapiens golgi autoantigen, golgin subfamily a-like, mRNA;																		GGCTGTAGTAAAGTGCCATCT	0.478000														50			3		0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156756826	156756826	+	Missense_Mutation	SNP	G	C	C	rs142005569		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:156756826G>C	uc001fqa.3	+	2	1233	c.943G>C	c.(943-945)Gat>Cat	p.D315H		NM_005973	NP_005964	Q92733	PRCC_HUMAN	Homo sapiens papillary renal cell carcinoma (translocation-associated) (PRCC), mRNA.	315					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTTCCAGGACGATGCAGCCAA	0.577000			T	TFE3	papillary renal									121			11		0	0	1	0	0
TMEM38B	55151	broad.mit.edu	37	9	108467983	108467983	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr9:108467983C>A	uc004bcu.1	+	1	335	c.218C>A	c.(217-219)cCa>cAa	p.P73Q	TMEM38B_uc010mtn.1_Missense_Mutation_p.P73Q	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	Homo sapiens transmembrane protein 38B (TMEM38B), mRNA.	73						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						GCAGAGCCTCCATTGAAGTTT	0.418000														49			14		1.45105e-14	2.00474e-14	1	1	0
ZAN	7455	broad.mit.edu	37	7	100385659	100385659	+	Silent	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:100385659C>T	uc003uwj.3	+	38	7290	c.7125C>T	c.(7123-7125)cgC>cgT	p.R2375R	ZAN_uc003uwk.3_Silent_p.R2375R|ZAN_uc003uwl.3_Non-coding_Transcript|ZAN_uc010lhh.3_Non-coding_Transcript|ZAN_uc010lhi.3_Non-coding_Transcript|ZAN_uc011kke.2_Silent_p.R426R	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	Homo sapiens zonadhesin (ZAN), transcript variant 3, mRNA.	2376	VWFD 4.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane		p.R2375H(1)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGGAAGGACGCAACAAGATGG	0.567000														44			8		0	0	1	0	0
CROCCP3	114819	broad.mit.edu	37	1	16809824	16809824	+	RNA	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:16809824C>T	uc001ays.2	-	6		c.897G>A			CROCCP3_uc001ayt.2_Non-coding_Transcript					Homo sapiens ciliary rootlet coiled-coil, rootletin pseudogene 3 (CROCCP3), non-coding RNA.																		CTGCACCTCGCGCTGGGCGTC	0.662000														9			3		0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933207	44933207	+	Silent	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:44933207C>T	uc002oze.1	-	5	2183	c.1749G>A	c.(1747-1749)cgG>cgA	p.R583R	ZNF229_uc010ejk.1_Silent_p.R237R|ZNF229_uc010ejl.1_Silent_p.R577R	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	Homo sapiens zinc finger protein 229 (ZNF229), mRNA.	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GGTCTGAATTCCGCCGGAAGC	0.572000														19			31		0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122432362	122432362	+	Silent	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:122432362G>A	uc003efq.4	+	9	3770	c.3711G>A	c.(3709-3711)acG>acA	p.T1237T	PARP14_uc021xdc.1_Silent_p.T1101T|PARP14_uc010hrk.3_Non-coding_Transcript|PARP14_uc003efr.3_Silent_p.T954T|PARP14_uc003efs.1_Silent_p.T954T	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	Homo sapiens poly (ADP-ribose) polymerase family, member 14 (PARP14), mRNA.	1237	Macro 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		GAGATATCACGAAAGAAGAGG	0.383000														2			21		0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53787666	53787666	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:53787666T>C	uc003dgv.4	+	28	3906	c.3743T>C	c.(3742-3744)tTc>tCc	p.F1248S	CACNA1D_uc003dgu.4_Missense_Mutation_p.F1268S|CACNA1D_uc003dgy.4_Missense_Mutation_p.F1248S|CACNA1D_uc003dgw.4_Missense_Mutation_p.F915S|CACNA1D_uc003dgx.1_Missense_Mutation_p.F396S	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	Homo sapiens calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), transcript variant 2, mRNA.	1248					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	ACCGGGGTGTTCACCGTCGAG	0.478000														4			20		0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106687	55106687	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:55106687G>A	uc002qgh.1	+	4	663	c.481G>A	c.(481-483)Gaa>Aaa	p.E161K	LILRA1_uc010yfg.1_Intron|LILRA1_uc010yfh.2_Missense_Mutation_p.E161K	NM_006863	NP_006854	O75019	LIRA1_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 (LILRA1), mRNA.	161	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		TAAGGAAGGAGAAGATGAACA	0.592000														67			94		0	0	1	0	0
CYP2S1	29785	broad.mit.edu	37	19	41700534	41700534	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:41700534G>T	uc002opw.3	+	1	318	c.263G>T	c.(262-264)cGg>cTg	p.R88L	CYP2S1_uc010xvx.2_5'UTR	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	Homo sapiens cytochrome P450, family 2, subfamily S, polypeptide 1 (CYP2S1), mRNA.	88					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						GAGGCTGTGCGGGAGGCCCTG	0.632000														27			15		1.49906e-05	1.7489e-05	1	1	0
RPL32P3	132241	broad.mit.edu	37	3	129116038	129116038	+	RNA	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:129116038C>T	uc003eme.1	-	0		c.760G>A			RPL32P3_uc003ema.3_Intron|RPL32P3_uc003emb.3_Intron|RPL32P3_uc003emd.1_Intron					Homo sapiens ribosomal protein L32 pseudogene 3 (RPL32P3), non-coding RNA.											lung(1)	1						GAGGCTTTCCCGCCCAGGGAC	0.567000														57			5		0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91226264	91226264	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:91226264C>T	uc003pnz.1	-	16	2082	c.1777G>A	c.(1777-1779)Gag>Aag	p.E593K	MAP3K7_uc003pny.1_Missense_Mutation_p.E130K|MAP3K7_uc003pob.1_Missense_Mutation_p.E566K|MAP3K7_uc003poa.1_3'UTR|MAP3K7_uc003poc.1_3'UTR	NM_145331	NP_663304	O43318	M3K7_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant B, mRNA.	593					I-kappaB phosphorylation|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|positive regulation of interleukin-2 production|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|MAP kinase kinase kinase activity|magnesium ion binding|protein binding	p.E566K(1)|p.E593K(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTGATGACCTCTAGTTGTTTT	0.378000														50			21		0	0	1	0	0
AKR7A3	22977	broad.mit.edu	37	1	19612766	19612766	+	Silent	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:19612766G>A	uc001bbv.1	-	1	392	c.315C>T	c.(313-315)ccC>ccT	p.P105P		NM_012067	NP_036199	O95154	ARK73_HUMAN	Homo sapiens aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) (AKR7A3), mRNA.	105					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity			NS(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|stomach(2)	13		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GGTCCACTCGGGGACACTGCA	0.592000														45			28		0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286355	152286355	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:152286355G>C	uc001ezu.1	-	2	1043	c.1007C>G	c.(1006-1008)cCc>cGc	p.P336R	AK056431_uc001ezv.3_Non-coding_Transcript	NM_002016	NP_002007	P20930	FILA_HUMAN	Homo sapiens filaggrin (FLG), mRNA.	336	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGGACCTGGGGTGTCTGGA	0.562000									Ichthyosis					145			28		0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335488	20335488	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr16:20335488G>T	uc002dgv.3	-	2	268	c.185C>A	c.(184-186)cCc>cAc	p.P62H	GP2_uc002dgw.3_Missense_Mutation_p.P62H|GP2_uc002dgx.3_Intron|GP2_uc002dgy.3_Intron	NM_001007240	NP_001007241	P55259	GP2_HUMAN	Homo sapiens glycoprotein 2 (zymogen granule membrane) (GP2), transcript variant 1, mRNA.	62						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ATTCTGACAGGGGTCAAAACA	0.552000														34			11		1.61879e-10	2.15156e-10	1	1	0
RYR1	6261	broad.mit.edu	37	19	38993211	38993211	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:38993211C>T	uc002oit.3	+	47	7809	c.7679C>T	c.(7678-7680)cCg>cTg	p.P2560L	RYR1_uc002oiu.3_Missense_Mutation_p.P2560L|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	Homo sapiens ryanodine receptor 1 (skeletal) (RYR1), transcript variant 1, mRNA.	2560	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	I band|cell cortex|cytosol|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.P2560L(2)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCCGTGCTGCCGCTCATCACC	0.647000														11			18		0	0	1	0	0
MAP3K7	6885	broad.mit.edu	37	6	91226396	91226396	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:91226396C>T	uc003pnz.1	-	16	1950	c.1645G>A	c.(1645-1647)Gaa>Aaa	p.E549K	MAP3K7_uc003pny.1_Missense_Mutation_p.E86K|MAP3K7_uc003pob.1_Missense_Mutation_p.E522K|MAP3K7_uc003poa.1_Missense_Mutation_p.R510K|MAP3K7_uc003poc.1_Missense_Mutation_p.R483K	NM_145331	NP_663304	O43318	M3K7_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant B, mRNA.	549					I-kappaB phosphorylation|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|T cell receptor signaling pathway|Toll signaling pathway|activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|positive regulation of interleukin-2 production|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|MAP kinase kinase kinase activity|magnesium ion binding|protein binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	28		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		GCAACTAGTTCTTGCCTACAA	0.353000														19			12		0	0	1	0	0
ANKMY2	57037	broad.mit.edu	37	7	16640497	16640497	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:16640497C>A	uc003sti.3	-	9	1459	c.1215G>T	c.(1213-1215)aaG>aaT	p.K405N	ANKMY2_uc010ktz.3_Non-coding_Transcript	NM_020319	NP_064715	Q8IV38	ANKY2_HUMAN	Homo sapiens ankyrin repeat and MYND domain containing 2 (ANKMY2), mRNA.	405						cilium	zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		GATTGGAATCCTTTTGAGAGA	0.423000														39			3		1	1	1	1	0
TEKT5	146279	broad.mit.edu	37	16	10770001	10770001	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr16:10770001C>T	uc002czz.1	-	4	973	c.901G>A	c.(901-903)Gac>Aac	p.D301N		NM_144674	NP_653275	Q96M29	TEKT5_HUMAN	Homo sapiens tektin 5 (TEKT5), mRNA.	301					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						TTGATGTTGTCGTTACTGAAC	0.552000														27			6		0	0	1	0	0
PRDM13	59336	broad.mit.edu	37	6	100062529	100062529	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:100062529C>T	uc003pqg.1	+	3	2279	c.2018C>T	c.(2017-2019)cCc>cTc	p.P673L		NM_021620	NP_067633	Q9H4Q3	PRD13_HUMAN	Homo sapiens PR domain containing 13 (PRDM13), mRNA.	673					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(1)	17		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		CCCGGCTATCCCCCGGAGCCT	0.716000														63			7		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118268	118268	+	RNA	SNP	G	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chrGL000205.1:118268G>C	uc002kgk.4	+	0		c.1646G>C								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		AAACCAGCAAGAAATTCATCC	0.512000														16			11		0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358370	10358370	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr17:10358370C>T	uc002gmn.3	-	20	2434	c.2323G>A	c.(2323-2325)Gga>Aga	p.G775R	AK097500_uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	Homo sapiens myosin, heavy chain 4, skeletal muscle (MYH4), mRNA.	775	Actin-binding (By similarity).|Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	ATP binding|actin binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TCTAGAGTTCCCAGCAGGCCA	0.403000														23			234		0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25043609	25043609	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:25043609C>T	uc001wpq.3	-	3	473	c.436G>A	c.(436-438)Ggc>Agc	p.G146S		NM_001911	NP_001902	P08311	CATG_HUMAN	Homo sapiens cathepsin G (CTSG), mRNA.	146	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		CTGCCCCAGCCGGCCACAGTG	0.612000														118			25		0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92472033	92472033	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:92472033G>A	uc001xzy.3	-	10	2661	c.2287C>T	c.(2287-2289)Cat>Tat	p.H763Y	TRIP11_uc010auf.2_Missense_Mutation_p.H499Y	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.	763					transcription from RNA polymerase II promoter	Golgi apparatus|cytoskeleton|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TTAATTAAATGCTCATGTTCC	0.343000			T	PDGFRB	AML									119			28		0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45742035	45742035	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr21:45742035A>G	uc002zek.3	+	16	1900	c.1499A>G	c.(1498-1500)cAc>cGc	p.H500R	PFKL_uc002zel.3_Missense_Mutation_p.H453R|PFKL_uc002zem.3_Missense_Mutation_p.H40R|PFKL_uc002zen.3_Missense_Mutation_p.H40R			P17858	K6PL_HUMAN	Homo sapiens phosphofructokinase, liver (PFKL), transcript variant 1, non-coding RNA.	453					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GTAGGCTGGCACGACGTGGCC	0.701000														24			34		0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	160977080	160977080	+	Silent	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:160977080C>T	uc003qtl.3	-	30	5070	c.4950G>A	c.(4948-4950)agG>agA	p.R1650R		NM_005577	NP_005568	P08519	APOA_HUMAN	Homo sapiens lipoprotein, Lp(a) (LPA), mRNA.	4158	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TTTCTGGGGTCCTCTGATGCC	0.468000														39			18		0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50686456	50686456	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr10:50686456G>A	uc001jhs.4	-	10	2384	c.2230C>T	c.(2230-2232)Cgg>Tgg	p.R744W	ERCC6_uc009xod.3_5'Flank|ERCC6_uc010qgr.2_Missense_Mutation_p.R114W|ERCC6_uc001jhr.4_Missense_Mutation_p.R144W	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6), mRNA.	744					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|DNA binding|DNA-dependent ATPase activity|chromatin binding|helicase activity|protein C-terminus binding|protein N-terminus binding|protein complex binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TTCATTCTCCGCAGTAGGTAT	0.383000								Direct reversal of damage;Nucleotide excision repair (NER)						119			4		0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18691938	18691938	+	Silent	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:18691938C>A	uc001bau.2	+	5	1145	c.762C>A	c.(760-762)ccC>ccA	p.P254P	IGSF21_uc001bav.2_Silent_p.P75P	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	Homo sapiens immunoglobin superfamily, member 21 (IGSF21), mRNA.	254						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CCCCAGATCCCAACATCCTCC	0.637000														164			6		8.12818e-05	9.37867e-05	1	1	0
TRIP11	9321	broad.mit.edu	37	14	92471090	92471090	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:92471090G>A	uc001xzy.3	-	10	3604	c.3230C>T	c.(3229-3231)tCa>tTa	p.S1077L	TRIP11_uc010auf.2_Missense_Mutation_p.S813L	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.	1077					transcription from RNA polymerase II promoter	Golgi apparatus|cytoskeleton|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		ATGGGAAGTTGAAGAAATTCT	0.368000			T	PDGFRB	AML									47			12		0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471136	92471136	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr14:92471136G>T	uc001xzy.3	-	10	3558	c.3184C>A	c.(3184-3186)Cag>Aag	p.Q1062K	TRIP11_uc010auf.2_Missense_Mutation_p.Q798K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.	1062					transcription from RNA polymerase II promoter	Golgi apparatus|cytoskeleton|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TCTTTCTGCTGAATAATCTGA	0.343000			T	PDGFRB	AML									42			8		5.4927e-09	7.20917e-09	1	1	0
THSD7A	221981	broad.mit.edu	37	7	11485803	11485803	+	Silent	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:11485803C>A	uc021zzo.1	-	12	3201	c.2949G>T	c.(2947-2949)ctG>ctT	p.L983L	THSD7A_uc021zzn.1_Silent_p.L983L	NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	Homo sapiens thrombospondin, type I, domain containing 7A (THSD7A), mRNA.	983	TSP type-1 10.					integral to membrane		p.L982F(1)		NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTTTCATTCCCAGCAACACTT	0.433000										HNSCC(18;0.044)				86			4		1.23904e-05	1.46179e-05	1	1	0
BTNL8	79908	broad.mit.edu	37	5	180338480	180338480	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr5:180338480G>T	uc003mmp.3	+	2	773	c.539G>T	c.(538-540)aGg>aTg	p.R180M	BTNL8_uc003mmq.3_Missense_Mutation_p.R180M|BTNL8_uc010jll.3_Missense_Mutation_p.R180M|BTNL8_uc011dhg.2_Missense_Mutation_p.R55M|BTNL8_uc010jlm.3_Missense_Mutation_p.R64M|BTNL8_uc011dhh.2_5'UTR	NM_001040462	NP_001153182	Q6UX41	BTNL8_HUMAN	Homo sapiens butyrophilin-like 8 (BTNL8), transcript variant 2, mRNA.	180	Ig-like V-type 2.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACAGACTCCAGGACAAACAGA	0.552000														91			24		2.21704e-12	3.02323e-12	1	1	0
SNX25	83891	broad.mit.edu	37	4	186180144	186180144	+	Silent	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr4:186180144G>T	uc003ixh.3	+	2	354	c.165G>T	c.(163-165)gtG>gtT	p.V55V		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	Homo sapiens sorting nexin 25 (SNX25), mRNA.	55	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(8)|lung(13)|ovary(2)|pancreas(2)|prostate(2)|urinary_tract(2)	40		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		ACGTGGATGTGGTTAAAGTTG	0.468000														31			3		1	1	1	1	0
EML2	24139	broad.mit.edu	37	19	46124878	46124878	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr19:46124878G>C	uc010xxm.2	-	12	1535	c.1462C>G	c.(1462-1464)Cag>Gag	p.Q488E	EML2_uc002pcn.3_Missense_Mutation_p.Q287E|EML2_uc002pcp.3_Missense_Mutation_p.Q171E|EML2_uc002pco.3_Non-coding_Transcript|EML2_uc010xxl.2_Missense_Mutation_p.Q434E|EML2_uc010xxn.1_Non-coding_Transcript|EML2_uc010xxo.2_Missense_Mutation_p.Q287E|EML2_uc010ekj.3_Missense_Mutation_p.H253Q	NM_001193268	NP_001180197	O95834	EMAL2_HUMAN	Homo sapiens echinoderm microtubule associated protein like 2 (EML2), transcript variant 1, mRNA.	287					sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|urinary_tract(1)	31		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		AGCACCGCCTGTGTGATACGG	0.667000														6			8		0	0	1	0	0
MICB	4277	broad.mit.edu	37	6	31474904	31474904	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:31474904G>A	uc003ntn.4	+	3	835	c.719G>A	c.(718-720)cGt>cAt	p.R240H	MICB_uc011dnm.2_Missense_Mutation_p.R208H|MICB_uc021yuq.1_Missense_Mutation_p.R208H|MICB_uc003nto.4_Missense_Mutation_p.R197H	NM_005931	NP_005922	Q29980	MICB_HUMAN	Homo sapiens MHC class I polypeptide-related sequence B (MICB), mRNA.	240	Ig-like C1-type.				antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	MHC class I protein complex|integral to plasma membrane	natural killer cell lectin-like receptor binding	p.R240C(1)		NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						CTGACCTGGCGTCAGGATGGG	0.582000														31			22		0	0	1	0	0
INHBB	3625	broad.mit.edu	37	2	121107068	121107068	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:121107068G>A	uc002tmn.2	+	1	888	c.842G>A	c.(841-843)cGg>cAg	p.R281Q		NM_002193	NP_002184	P09529	INHBB_HUMAN	Homo sapiens inhibin, beta B (INHBB), mRNA.	281					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(4)|pancreas(2)|skin(2)	15		Prostate(154;0.122)				GTGCAGGCTCGGCTGGGCGAC	0.642000														58			26		0	0	1	0	0
ARID5A	10865	broad.mit.edu	37	2	97217113	97217113	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr2:97217113G>A	uc002swe.3	+	6	948	c.848G>A	c.(847-849)gGg>gAg	p.G283E	ARID5A_uc010yuq.2_Missense_Mutation_p.G231E|ARID5A_uc002swf.3_Missense_Mutation_p.G119E|ARID5A_uc002swg.3_Missense_Mutation_p.G231E	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	Homo sapiens AT rich interactive domain 5A (MRF1-like) (ARID5A), mRNA.	283					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|skin(1)|urinary_tract(2)	14						TGCCGCCATGGGGCAGAGCCC	0.652000														24			4		0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37271732	37271732	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:37271732T>A	uc001caz.2	-	13	2422	c.2287A>T	c.(2287-2289)Aag>Tag	p.K763*	GRIK3_uc001cba.1_Nonsense_Mutation_p.K763*	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	Homo sapiens glutamate receptor, ionotropic, kainate 3 (GRIK3), mRNA.	763					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	G-protein-coupled receptor binding|adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CCGTAGCCCTTGGAGTCAATG	0.672000														46			8		0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	Missense_Mutation	SNP	C	T	T	rs141013110		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr6:26422353C>T	uc011dkl.1	+	0	37	c.7C>T	c.(7-9)Cca>Tca	p.P3S	BTN2A3P_uc011dkm.2_Non-coding_Transcript					Homo sapiens butyrophilin, subfamily 2, member A3, pseudogene (BTN2A3P), non-coding RNA.									p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000														96			4		0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71715809	71715809	+	Splice_Site	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr16:71715809C>T	uc002fax.3	-	5	742	c.736_splice	c.e5-1	p.V246_splice	PHLPP2_uc002fav.3_Splice_Site|PHLPP2_uc010cgf.3_Splice_Site_p.V246_splice|PHLPP2_uc002fay.1_Splice_Site_p.V246_splice	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	Homo sapiens PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2), mRNA.	246	PH.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						GGGACACCACCTGAATAATGT	0.433000														20			8		0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55534084	55534084	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr8:55534084C>A	uc003xsd.1	+	1	706	c.558C>A	c.(556-558)caC>caA	p.H186Q	RP1_uc011ldy.1_Missense_Mutation_p.H186Q	NM_006269	NP_006260	P56715	RP1_HUMAN	Homo sapiens retinitis pigmentosa 1 (autosomal dominant) (RP1), mRNA.	186	Doublecortin 2.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCTACAGCACCTGACAGAGG	0.602000														158			66		6.8682e-38	9.87892e-38	1	1	0
MAP1LC3C	440738	broad.mit.edu	37	1	242161837	242161837	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:242161837G>A	uc001hzk.2	-	2	275	c.200C>T	c.(199-201)aCc>aTc	p.T67I		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	Homo sapiens microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C), mRNA.	67					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding	p.T67T(1)		endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GAGGAACTGGGTCATGGTCAG	0.622000											OREG0014354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		28			18		0	0	1	0	0
GDF10	2662	broad.mit.edu	37	10	48426603	48426603	+	Silent	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr10:48426603G>T	uc001jfb.3	-	2	1832	c.1404C>A	c.(1402-1404)ccC>ccA	p.P468P	GDF10_uc009xnp.3_Silent_p.P467P	NM_004962	NP_004953	P55107	BMP3B_HUMAN	Homo sapiens growth differentiation factor 10 (GDF10), mRNA.	468					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						CGGACATGTTGGGGTACACCT	0.587000											OREG0020165	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		96			5		0.00116845	0.00129144	1	1	0
SLC6A11	6538	broad.mit.edu	37	3	10960063	10960063	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr3:10960063G>T	uc003bvz.3	+	7	1079	c.1045G>T	c.(1045-1047)Ggg>Tgg	p.G349W		NM_014229	NP_055044	P48066	S6A11_HUMAN	Homo sapiens solute carrier family 6 (neurotransmitter transporter, GABA), member 11 (SLC6A11), mRNA.	349					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		CTTCGTGGCTGGGTTTGCCAT	0.597000														13			19		1.67942e-08	2.17702e-08	1	1	0
SAMD9L	219285	broad.mit.edu	37	7	92761033	92761033	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:92761033C>A	uc003umh.1	-	4	5468	c.4252G>T	c.(4252-4254)Gga>Tga	p.G1418*	SAMD9L_uc003umj.1_Nonsense_Mutation_p.G1418*|SAMD9L_uc003umi.1_Nonsense_Mutation_p.G1418*|SAMD9L_uc010lfb.1_Nonsense_Mutation_p.G1418*|SAMD9L_uc003umk.1_Nonsense_Mutation_p.G1418*|SAMD9L_uc010lfc.1_Nonsense_Mutation_p.G1418*|SAMD9L_uc010lfd.1_Nonsense_Mutation_p.G1418*|SAMD9L_uc022ahh.1_Nonsense_Mutation_p.G1418*	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	Homo sapiens sterile alpha motif domain containing 9-like (SAMD9L), mRNA.	1418										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGACTTAGTCCTACAAATTGC	0.398000														98			12		1.61879e-10	2.15156e-10	1	1	0
OR1L6	392390	broad.mit.edu	37	9	125512476	125512476	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr9:125512476C>T	uc022bna.1	+	0	350	c.350C>T	c.(349-351)gCc>gTc	p.A117V		NM_001004453	NP_001004453	Q8NGR2	OR1L6_HUMAN	Homo sapiens olfactory receptor, family 1, subfamily L, member 6 (OR1L6), mRNA.	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						TACCTGCTGGCCTCTATGGCC	0.502000														80			6		0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2962795	2962795	+	Missense_Mutation	SNP	C	A	A	rs146070546		TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr7:2962795C>A	uc003smv.3	-	15	2447	c.2113G>T	c.(2113-2115)Ggc>Tgc	p.G705C		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	Homo sapiens caspase recruitment domain family, member 11 (CARD11), mRNA.	705	PDZ.				T cell costimulation|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of cytokine production|regulation of apoptosis	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCACGGAGGCCGGCTTTCTCG	0.652000			Mis		DLBCL									37			3		2.56e-06	3.23855e-06	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70956768	70956768	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr12:70956768C>A	uc001swb.4	-	13	3400	c.3370G>T	c.(3370-3372)Ggg>Tgg	p.G1124W	PTPRB_uc010sto.2_Missense_Mutation_p.G1034W|PTPRB_uc010stp.2_Missense_Mutation_p.G1034W|PTPRB_uc001swc.4_Missense_Mutation_p.G1342W|PTPRB_uc001swa.4_Missense_Mutation_p.G1254W|PTPRB_uc001swd.4_Missense_Mutation_p.G1341W|PTPRB_uc009zrr.2_Missense_Mutation_p.G1221W	NM_002837	NP_002828	P23467	PTPRB_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, B (PTPRB), transcript variant 2, mRNA.	1124	Fibronectin type-III 13.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGGAGATTCCCATCTGGGTTG	0.512000														27			6		0.00198382	0.0021698	1	1	0
ABL2	27	broad.mit.edu	37	1	179078493	179078493	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr1:179078493delC	uc001gmj.4	-	11	2196	c.1909delG	c.(1909-1911)gaafs	p.E637fs	ABL2_uc010pnf.2_Frame_Shift_Del_p.E637fs|ABL2_uc010png.2_Frame_Shift_Del_p.E616fs|ABL2_uc010pnh.2_Frame_Shift_Del_p.E616fs|ABL2_uc001gmg.4_Frame_Shift_Del_p.E622fs|ABL2_uc001gmi.4_Frame_Shift_Del_p.E622fs|ABL2_uc010pne.2_Frame_Shift_Del_p.E601fs	NM_007314	NP_009298	P42684	ABL2_HUMAN	Homo sapiens v-abl Abelson murine leukemia viral oncogene homolog 2 (ABL2), transcript variant b, mRNA.	637					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TTGGCATCTTCCAAGAGGCTG	0.542			T	ETV6	AML								---	53	---	---	65	---					
LOC440434	440434	broad.mit.edu	37	17	36412964	36412964	+	RNA	DEL	A	-	-			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr17:36412964delA	uc002hpx.2	-	1		c.231delT								Homo sapiens aminopeptidase puromycin sensitive pseudogene (LOC440434), non-coding RNA.																		GGCTTGAGGCAAAGGCTGCAG	0.706													---	4	---	---	2	---					
FHOD3	80206	broad.mit.edu	37	18	34261459	34261460	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr18:34261459_34261460delAG	uc021uiv.1	+	14	1993_1994	c.1896_1897delAG	c.(1894-1899)gcagagfs	p.A632fs	FHOD3_uc002kzr.1_Frame_Shift_Del_p.A457fs|FHOD3_uc002kzs.1_Frame_Shift_Del_p.A457fs|FHOD3_uc002kzt.1_Frame_Shift_Del_p.A457fs|FHOD3_uc010dmz.1_Frame_Shift_Del_p.A172fs	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	Homo sapiens formin homology 2 domain containing 3 (FHOD3), mRNA.	457	Poly-Ser.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CACTGGCAGCAGAGAGAGAGAG	0.460													---	62	---	---	8	---					
SEL1L2	80343	broad.mit.edu	37	20	13830156	13830156	+	Frame_Shift_Del	DEL	A	-	-			TCGA-D9-A4Z5-01A-11D-A25O-08	TCGA-D9-A4Z5-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D486B1EB-917D-4F21-8B9D-51D1F962B129	07157C0C-E999-48BF-865E-7AFE56A91202	g.chr20:13830156delA	uc010gcf.3	-	19	2124	c.2042delT	c.(2041-2043)ttgfs	p.L681fs	SEL1L2_uc002woq.4_Frame_Shift_Del_p.L542fs|SEL1L2_uc010zrl.2_Frame_Shift_Del_p.L568fs|SEL1L2_uc002wor.3_Non-coding_Transcript	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	Homo sapiens sel-1 suppressor of lin-12-like 2 (C. elegans) (SEL1L2), mRNA.	681						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						TCTAAGCAACAAAATCAGCCC	0.473													---	22	---	---	29	---