Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
DOCK2	0	genome.wustl.edu	37	5	169469044	169469044	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	5	169469044	169469044	G	A	SNP	DOCK2	ENST00000256935	human	ensembl	74_37	+1	known	missense	c.3784	p.V1262I	1.000	NULL	pfam_DOCK_C,pfam_SH3_2,superfamily_SH3_domain,superfamily_Cyt_c-like_dom,superfamily_ARM-type_fold,superfamily_Ferritin-like_SF,smart_SH3_domain,pfscan_SH3_domain	-	no_errors	DOCK2	HGNC	ENSG00000134516	tier1	-	-	32	0	0.00	9	5	35.71	46	0	0.00	21	8	27.59
ENSG00000221186	0	genome.wustl.edu	37	4	183747503	183747503	+	R	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	4	183747503	183747503	C	T	SNP	ENSG00000221186	ENST00000408259	human	ensembl	74_37	+1	novel	rna	NULL	NULL	0.000	-	-	-	no_errors	AC114798.1	Clone_based_ensembl_gene	ENSG00000221186	tier1	-	-	138	0	0.00	77	33	30.00	71	0	0.00	56	20	26.32
MCF2L	0	genome.wustl.edu	37	13	113732739	113732739	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	13	113732739	113732739	C	T	SNP	MCF2L	ENST00000375604	human	ensembl	74_37	+1	known	missense	c.1894	p.R632W	0.997	NULL	pfam_DH-domain,pfam_Spectrin_repeat,pfam_Pleckstrin_homology,pfam_SH3_2,superfamily_DH-domain,superfamily_SH3_domain,superfamily_CRAL-TRIO_dom,smart_CRAL-TRIO_dom,smart_Spectrin/alpha-actinin,smart_DH-domain,smart_Pleckstrin_homology,smart_SH3_domain,pfscan_CRAL-TRIO_dom,pfscan_Pleckstrin_homology,pfscan_SH3_domain,pfscan_DH-domain	-	no_errors	MCF2L	HGNC	ENSG00000126217	tier1	-	-	43	0	0.00	56	14	20.00	62	0	0.00	68	10	12.82
COL16A1	0	genome.wustl.edu	37	1	32151243	32151243	+	Silent	SNP	T	T	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	32151243	32151243	T	C	SNP	COL16A1	ENST00000271069	human	ensembl	74_37	-1	known	silent	c.2010	p.K670	0.987	pfam_Collagen	pfam_Collagen,superfamily_ConA-like_lec_gl_sf,smart_Laminin_G	-	no_errors	COL16A1	HGNC	ENSG00000084636	tier1	-	-	125	0	0.00	67	26	27.96	65	0	0.00	25	20	44.44
DK	0	genome.wustl.edu	37	1	1684501	1684501	+	Splice_Site	SNP	T	T	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	1684501	1684501	T	A	SNP	DK	ENST00000344463	human	ensembl	74_37	-1	known	splice_site	c.1620-2	e13-2	1.000	-	-	-	no_errors	DK	HGNC	ENSG00000008130	tier1	-	-	79	0	0.00	14	60	80.00	39	0	0.00	10	41	80.39
TEKT2	0	genome.wustl.edu	37	1	36553137	36553137	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	36553137	36553137	T	A	SNP	TEKT2	ENST00000207457	human	ensembl	74_37	+1	known	missense	c.953	p.L318Q	1.000	pfam_Tektin,superfamily_Prefoldin,prints_Tektin	pfam_Tektin,superfamily_Prefoldin,prints_Tektin	-	no_errors	TEKT2	HGNC	ENSG00000092850	tier1	-	-	72	0	0.00	35	37	51.39	49	0	0.00	30	23	43.40
CD84	0	genome.wustl.edu	37	1	160535413	160535413	+	Missense_Mutation	SNP	T	T	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	160535413	160535413	T	C	SNP	CD84	ENST00000311224	human	ensembl	74_37	-1	novel	missense	c.169	p.K57E	0.000	smart_Ig_sub	smart_Ig_sub,pfscan_Ig-like_dom	-	no_errors	CD84	HGNC	ENSG00000066294	tier1	-	-	54	0	0.00	55	14	20.29	136	0	0.00	100	24	19.35
MIP	0	genome.wustl.edu	37	12	56848076	56848076	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	12	56848076	56848076	T	A	SNP	MIP	ENST00000257979	human	ensembl	74_37	-1	known	missense	c.322	p.T108S	1.000	pfam_MIP,superfamily_Aquaporin-like,tigrfam_MIP	pfam_MIP,superfamily_Aquaporin-like,prints_MIP,tigrfam_MIP	-	no_errors	MIP	HGNC	ENSG00000135517	tier1	-	-	45	0	0.00	10	24	70.59	121	0	0.00	16	72	81.82
ZZZ3	0	genome.wustl.edu	37	1	78031815	78031815	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	78031815	78031815	C	T	SNP	ZZZ3	ENST00000370801	human	ensembl	74_37	-1	known	missense	c.2518	p.D840N	1.000	pfam_Znf_ZZ,pfscan_Znf_ZZ	pfam_SANT/Myb,pfam_Znf_ZZ,superfamily_Homeodomain-like,smart_SANT/Myb,pfscan_Znf_ZZ,pfscan_Myb-like_dom	-	no_errors	ZZZ3	HGNC	ENSG00000036549	tier1	-	-	109	0	0.00	107	19	15.08	103	0	0.00	103	37	26.43
DHRS9	0	genome.wustl.edu	37	2	169948327	169948327	+	Silent	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	2	169948327	169948327	C	T	SNP	DHRS9	ENST00000432060	human	ensembl	74_37	+1	known	silent	c.780	p.H260	0.767	prints_Glc/ribitol_DH	pfam_DH_sc/Rdtase_SDR,prints_Glc/ribitol_DH,prints_DH_sc/Rdtase_SDR	-	no_errors	DHRS9	HGNC	ENSG00000073737	tier1	-	-	100	0	0.00	27	44	61.97	143	0	0.00	22	49	69.01
TBC1D1	0	genome.wustl.edu	37	4	38134403	38134403	+	R	SNP	T	T	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	4	38134403	38134403	T	A	SNP	TBC1D1	ENST00000405444	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	TBC1D1	HGNC	ENSG00000065882	tier1	-	-	107	0	0.00	90	56	38.36	22	0	0.00	12	11	47.83
ARHGAP27	0	genome.wustl.edu	37	17	43481440	43481440	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	17	43481440	43481440	C	A	SNP	ARHGAP27	ENST00000428638	human	ensembl	74_37	-1	known	missense	c.1502	p.G501V	0.998	pfam_Pleckstrin_homology,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology	pfam_RhoGAP_dom,pfam_WW_dom,pfam_Pleckstrin_homology,superfamily_Rho_GTPase_activation_prot,superfamily_SH3_domain,superfamily_WW_dom,smart_WW_dom,smart_Pleckstrin_homology,smart_RhoGAP_dom,pfscan_Pleckstrin_homology,pfscan_SH3_domain,pfscan_WW_dom,pfscan_RhoGAP_dom	-	no_errors	ARHGAP27	HGNC	ENSG00000159314	tier1	-	-	29	0	0.00	18	8	30.77	56	0	0.00	32	13	28.89
TMEM2	0	genome.wustl.edu	37	9	74365130	74365130	+	Silent	SNP	G	G	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	9	74365130	74365130	G	T	SNP	TMEM2	ENST00000377044	human	ensembl	74_37	-1	known	silent	c.160	p.R54	1.000	NULL	pfam_G8_domain,superfamily_Pectin_lyase_fold/virulence	-	no_errors	TMEM2	HGNC	ENSG00000135048	tier1	-	-	108	0	0.00	72	23	24.21	102	0	0.00	102	18	15.00
LRP5	0	genome.wustl.edu	37	11	68204446	68204446	+	Missense_Mutation	SNP	G	G	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	68204446	68204446	G	T	SNP	LRP5	ENST00000294304	human	ensembl	74_37	+1	known	missense	c.4090	p.G1364C	0.993	pirsf_Low_density_Lipo_rcpt-rel_p5/6,pfam_LDrepeatLR_classA_rpt,superfamily_LDrepeatLR_classA_rpt,smart_LDrepeatLR_classA_rpt,prints_LDrepeatLR_classA_rpt,pfscan_LDrepeatLR_classA_rpt	pirsf_Low_density_Lipo_rcpt-rel_p5/6,pfam_LDLR_classB_rpt,pfam_LDrepeatLR_classA_rpt,superfamily_LDrepeatLR_classA_rpt,smart_LDLR_classB_rpt,smart_EG-like_dom,smart_LDrepeatLR_classA_rpt,prints_LDrepeatLR_classA_rpt,pfscan_LDrepeatLR_classA_rpt,pfscan_LDLR_classB_rpt	-	no_errors	LRP5	HGNC	ENSG00000162337	tier1	-	-	38	0	0.00	19	27	58.70	51	1	1.89	43	32	42.67
INTS5	0	genome.wustl.edu	37	11	62416816	62416816	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	62416816	62416816	C	A	SNP	INTS5	ENST00000330574	human	ensembl	74_37	-1	known	missense	c.736	p.G246C	1.000	NULL	NULL	-	no_errors	INTS5	HGNC	ENSG00000185085	tier1	-	-	100	0	0.00	56	41	42.27	135	0	0.00	86	103	54.21
COPS4	0	genome.wustl.edu	37	4	83987617	83987617	+	Missense_Mutation	SNP	A	A	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	4	83987617	83987617	A	T	SNP	COPS4	ENST00000264389	human	ensembl	74_37	+1	known	missense	c.913	p.I305F	1.000	pfam_PCI_dom,smart_PCI_dom	pfam_PCI_dom,smart_PCI_dom	-	no_errors	COPS4	HGNC	ENSG00000138663	tier1	-	-	108	0	0.00	103	19	15.57	98	0	0.00	51	15	22.73
COL4A1	0	genome.wustl.edu	37	13	110828798	110828798	+	Nonsense_Mutation	SNP	C	C	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	13	110828798	110828798	C	A	SNP	COL4A1	ENST00000375820	human	ensembl	74_37	-1	known	nonsense	c.3031	p.G1011*	1.000	pfam_Collagen	pfam_Collagen,pfam_Collagen_VI_NC,superfamily_C-type_lectin_fold,smart_Collagen_VI_NC	-	no_errors	COL4A1	HGNC	ENSG00000187498	tier1	-	-	50	0	0.00	48	26	35.14	119	0	0.00	112	49	30.43
PZP	0	genome.wustl.edu	37	12	9312564	9312564	+	Missense_Mutation	SNP	T	T	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	12	9312564	9312564	T	C	SNP	PZP	ENST00000261336	human	ensembl	74_37	-1	known	missense	c.3107	p.E1036G	0.010	pfam_A2M_comp,superfamily_Terpenoid_cyclase/PrenylTrfase	pfam_A2M_comp,pfam_A2M_N_2,pfam_Macroglobln_a2,pfam_A-macroglobulin_rcpt-bd,pfam_A2M_N,pfam_MacrogloblnA2_thiol-ester-bond,pfam_SV_autoAg,superfamily_Terpenoid_cyclase/PrenylTrfase,superfamily_A-macroglobulin_rcpt-bd	-	no_errors	PZP	HGNC	ENSG00000126838	tier1	-	-	97	0	0.00	26	11	29.73	32	0	0.00	17	12	41.38
PGM1	0	genome.wustl.edu	37	1	64117302	64117302	+	R	SNP	A	A	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	64117302	64117302	A	C	SNP	PGM1	ENST00000483707	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	PGM1	HGNC	ENSG00000079739	tier1	-	-	76	0	0.00	10	47	82.46	79	0	0.00	26	50	65.79
DDX60	0	genome.wustl.edu	37	4	169196590	169196590	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	4	169196590	169196590	C	T	SNP	DDX60	ENST00000393743	human	ensembl	74_37	-1	known	missense	c.2210	p.R737Q	0.978	NULL	pfam_D/R_helicase_DEAD/DEAH_N,pfam_Helicase/UvrB_dom,pfam_Helicase_C,superfamily_P-loop_NTPase,smart_Helicase_ATP-bd,smart_Helicase_C,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	DDX60	HGNC	ENSG00000137628	tier1	-	-	104	0	0.00	49	22	30.99	99	0	0.00	81	38	31.93
TULP4	0	genome.wustl.edu	37	6	158915857	158915857	+	Silent	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	6	158915857	158915857	C	T	SNP	TULP4	ENST00000367097	human	ensembl	74_37	+1	known	silent	c.1849	p.L617	1.000	superfamily_Tubby_C-like	pfam_Tubby_C,pfam_SOCS_C,pfam_WD40_repeat,superfamily_Tubby_C-like,superfamily_WD40_repeat_dom,superfamily_Tumour_necrosis_fac-like_dom,smart_WD40_repeat,smart_SOCS_C,pfscan_SOCS_C,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	TULP4	HGNC	ENSG00000130338	tier1	-	-	47	0	0.00	13	8	38.10	119	0	0.00	46	37	44.58
GZF1	0	genome.wustl.edu	37	20	23345161	23345161	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	20	23345161	23345161	G	A	SNP	GZF1	ENST00000338121	human	ensembl	74_37	+1	known	missense	c.141	p.M47I	0.979	pfam_BTB_POZ,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,pfscan_BTB/POZ-like	pfam_Znf_C2H2,pfam_BTB_POZ,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,smart_Znf_C2H2-like,pfscan_BTB/POZ-like,pfscan_Znf_C2H2	-	no_errors	GZF1	HGNC	ENSG00000125812	tier1	-	-	65	0	0.00	24	28	53.85	130	0	0.00	44	37	45.68
ZNF277	0	genome.wustl.edu	37	7	111846832	111846832	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	7	111846832	111846832	T	A	SNP	ZNF277	ENST00000361822	human	ensembl	74_37	+1	known	missense	c.61	p.C21S	0.000	NULL	pfam_Znf_C2H2_jaz,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF277	HGNC	ENSG00000198839	tier1	-	-	175	0	0.00	94	27	22.31	40	0	0.00	25	16	39.02
BID	0	genome.wustl.edu	37	22	18220804	18220804	+	Silent	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	22	18220804	18220804	G	A	SNP	BID	ENST00000317361	human	ensembl	74_37	-1	known	silent	c.693	p.Y231	0.406	pfam_BID	pfam_BID	-	no_errors	BID	HGNC	ENSG00000015475	tier1	rs146712574	-	58	0	0.00	30	21	41.18	66	0	0.00	61	34	35.79
DSG2	0	genome.wustl.edu	37	18	29116347	29116347	+	Missense_Mutation	SNP	A	A	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	18	29116347	29116347	A	G	SNP	DSG2	ENST00000261590	human	ensembl	74_37	+1	known	missense	c.1606	p.K536E	0.011	superfamily_Cadherin-like	pfam_Cadherin,pfam_Cadherin_cytoplasmic-dom,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin,prints_Desmoglein,prints_Desmosomal_cadherin	-	no_errors	DSG2	HGNC	ENSG00000046604	tier1	-	-	49	0	0.00	19	10	34.48	144	0	0.00	59	57	49.14
AOC3	0	genome.wustl.edu	37	17	41007484	41007484	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	17	41007484	41007484	G	A	SNP	AOC3	ENST00000308423	human	ensembl	74_37	+1	known	missense	c.1910	p.R637Q	0.964	pfam_Cu_amine_oxidase_C,superfamily_Cu_amine_oxidase_C	pfam_Cu_amine_oxidase_C,pfam_Cu_amine_oxidase_N2,pfam_Cu_amine_oxidase_N3,superfamily_Cu_amine_oxidase_C,superfamily_Cu_amine_oxidase_N-reg,prints_Cu_amine_oxidase	-	no_errors	AOC3	HGNC	ENSG00000131471	tier1	-	-	58	0	0.00	16	16	50.00	71	0	0.00	36	27	42.86
WDR70	0	genome.wustl.edu	37	5	37443374	37443374	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	5	37443374	37443374	C	T	SNP	WDR70	ENST00000265107	human	ensembl	74_37	+1	known	missense	c.586	p.R196C	1.000	pfam_WD40_repeat,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	pfam_WD40_repeat,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	WDR70	HGNC	ENSG00000082068	tier1	-	-	44	0	0.00	22	30	57.69	73	0	0.00	36	61	62.89
SPATA5	0	genome.wustl.edu	37	4	123949450	123949450	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	4	123949450	123949450	C	T	SNP	SPATA5	ENST00000274008	human	ensembl	74_37	+1	known	missense	c.1979	p.P660L	1.000	superfamily_P-loop_NTPase,smart_AAA+_ATPase	pfam_ATPase_AAA_core,pfam_D_helicase_Holl-junc_RuvB_N,superfamily_P-loop_NTPase,superfamily_Asp_de-COase-like_dom,smart_AAA+_ATPase	-	no_errors	SPATA5	HGNC	ENSG00000145375	tier1	-	-	89	0	0.00	44	21	32.31	142	0	0.00	81	21	20.59
AP1M1	0	genome.wustl.edu	37	19	16339600	16339600	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	19	16339600	16339600	G	A	SNP	AP1M1	ENST00000444449	human	ensembl	74_37	+1	known	missense	c.944	p.R315Q	1.000	pfam_Clathrin_mu_C,superfamily_Clathrin_mu_C,pirsf_Clathrin_mu,pfscan_Clathrin_mu_C,prints_Clathrin_mu	pfam_Clathrin_mu_C,pfam_AP_mu_sigma_su,superfamily_Clathrin_mu_C,superfamily_Longin-like_dom,pirsf_Clathrin_mu,pfscan_Clathrin_mu_C,prints_Clathrin_mu	-	no_errors	AP1M1	HGNC	ENSG00000072958	tier1	-	-	82	0	0.00	43	30	41.10	73	0	0.00	41	12	22.64
RASA1	0	genome.wustl.edu	37	5	86645158	86645158	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	5	86645158	86645158	G	A	SNP	RASA1	ENST00000274376	human	ensembl	74_37	+1	known	missense	c.1230	p.M410I	1.000	pfam_SH2,smart_SH2,pfscan_SH2	pfam_SH2,pfam_RasGAP,pfam_Pleckstrin_homology,pfam_SH3_domain,pfam_C2_dom,superfamily_Rho_GTPase_activation_prot,superfamily_C2_dom,smart_SH2,smart_SH3_domain,smart_Pleckstrin_homology,smart_C2_dom,smart_RasGAP,pfscan_C2_dom,pfscan_Pleckstrin_homology,pfscan_SH2,pfscan_SH3_domain,pfscan_RasGAP,prints_SH2	-	no_errors	RASA1	HGNC	ENSG00000145715	tier1	-	-	92	0	0.00	80	26	24.53	158	0	0.00	99	32	24.43
KBTBD12	0	genome.wustl.edu	37	3	127642187	127642187	+	Missense_Mutation	SNP	G	G	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	3	127642187	127642187	G	C	SNP	KBTBD12	ENST00000405109	human	ensembl	74_37	+1	known	missense	c.283	p.E95Q	0.994	pfam_BTB_POZ,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,pirsf_Kelch-like_gigaxonin,pfscan_BTB/POZ-like	pfam_Kelch_1,pfam_BACK,pfam_BTB_POZ,pfam_Kelch_2,superfamily_BTB/POZ_fold,smart_BTB/POZ-like,smart_BACK,smart_Kelch_1,pirsf_Kelch-like_gigaxonin,pfscan_BTB/POZ-like	-	no_errors	KBTBD12	HGNC	ENSG00000187715	tier1	-	-	44	0	0.00	36	8	18.18	116	0	0.00	71	35	33.02
SDK2	0	genome.wustl.edu	37	17	71431719	71431719	+	Silent	SNP	G	G	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	17	71431719	71431719	G	C	SNP	SDK2	ENST00000392650	human	ensembl	74_37	-1	known	silent	c.1065	p.T355	0.054	pfam_Ig_I-set,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Fibronectin_type3,pfam_Ig_I-set,pfam_Immunoglobulin,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	SDK2	HGNC	ENSG00000069188	tier1	-	-	90	0	0.00	28	8	22.22	54	0	0.00	24	11	31.43
RASA1	0	genome.wustl.edu	37	5	86645033	86645033	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	5	86645033	86645033	G	A	SNP	RASA1	ENST00000274376	human	ensembl	74_37	+1	known	missense	c.1105	p.G369S	1.000	pfam_SH2,smart_SH2,pfscan_SH2	pfam_SH2,pfam_RasGAP,pfam_Pleckstrin_homology,pfam_SH3_domain,pfam_C2_dom,superfamily_Rho_GTPase_activation_prot,superfamily_C2_dom,smart_SH2,smart_SH3_domain,smart_Pleckstrin_homology,smart_C2_dom,smart_RasGAP,pfscan_C2_dom,pfscan_Pleckstrin_homology,pfscan_SH2,pfscan_SH3_domain,pfscan_RasGAP,prints_SH2	-	no_errors	RASA1	HGNC	ENSG00000145715	tier1	-	-	54	0	0.00	33	8	19.51	114	0	0.00	74	29	28.16
KCNH7	0	genome.wustl.edu	37	2	163279886	163279886	+	Missense_Mutation	SNP	T	T	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	2	163279886	163279886	T	C	SNP	KCNH7	ENST00000332142	human	ensembl	74_37	-1	known	missense	c.2114	p.Q705R	1.000	superfamily_cNMP-bd-like,prints_K_chnl_volt-dep_ERG	pfam_Ion_trans_dom,pfam_cNMP-bd_dom,pfam_2pore_dom_K_chnl_dom,pfam_PAS_fold_3,superfamily_cNMP-bd-like,superfamily_PAS,smart_cNMP-bd_dom,prints_K_chnl_volt-dep_EAG/ELK/ERG,prints_K_chnl_volt-dep_ERG,pfscan_cNMP-bd_dom,tigrfam_PAS	-	no_errors	KCNH7	HGNC	ENSG00000184611	tier1	-	-	103	0	0.00	92	13	12.38	127	0	0.00	130	18	12.16
BTN1A1	0	genome.wustl.edu	37	6	26505348	26505348	+	Missense_Mutation	SNP	T	T	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	6	26505348	26505348	T	C	SNP	BTN1A1	ENST00000244513	human	ensembl	74_37	+1	known	missense	c.623	p.I208T	0.013	pfam_CD80_C2-set,pfscan_Ig-like_dom	pfam_SPRY_rcpt,pfam_Ig_V-set,pfam_CD80_C2-set,superfamily_ConA-like_lec_gl_sf,smart_Ig_sub,smart_Ig_V-set_subgr,smart_PRY,smart_SPla/RYanodine_receptor_subgr,pfscan_B30.2/SPRY,pfscan_Ig-like_dom,prints_Butyrophylin	-	no_errors	BTN1A1	HGNC	ENSG00000124557	tier1	-	-	41	0	0.00	28	10	26.32	79	0	0.00	42	13	23.64
GRM5	0	genome.wustl.edu	37	11	88300954	88300954	+	Missense_Mutation	SNP	A	A	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	88300954	88300954	A	C	SNP	GRM5	ENST00000305447	human	ensembl	74_37	-1	known	missense	c.1897	p.F633V	1.000	pfam_GPCR_3_C,pfscan_GPCR_3_C	pfam_ANF_lig-bd_rcpt,pfam_GPCR_3_C,pfam_Metabotropic_Glu_rcpt_Homer-bd,pfam_GPCR_3_9-Cys_dom,superfamily_Peripla_BP_I,prints_GPCR_3_mtglu_rcpt_5,prints_GPCR_3,prints_GPCR_3_mtglu_rcpt,prints_GPCR_3_mtglu_rcpt_1,pfscan_GPCR_3_C	-	no_errors	GRM5	HGNC	ENSG00000168959	tier1	-	-	58	0	0.00	26	24	48.00	120	0	0.00	47	39	45.35
ENSG00000270540	0	genome.wustl.edu	37	2	237276995	237276995	+	R	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	2	237276995	237276995	G	A	SNP	ENSG00000270540	ENST00000605740	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	RP11-785G17.1	Clone_based_vega_gene	ENSG00000270540	tier1	-	-	40	0	0.00	8	19	70.37	91	1	1.09	22	36	62.07
GPR98	0	genome.wustl.edu	37	5	89990459	89990459	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	5	89990459	89990459	G	A	SNP	GPR98	ENST00000405460	human	ensembl	74_37	+1	known	missense	c.7886	p.G2629E	1.000	pfam_Calx_beta,smart_Calx_beta	pfam_Calx_beta,pfam_EPTP,pfam_GPCR_2_secretin-like,pfam_GPS_dom,superfamily_ConA-like_lec_gl_sf,superfamily_Gal_Oxase/kelch_b-propeller,smart_Calx_beta,pfscan_EAR,pfscan_GPS_dom,pfscan_GPCR_2-like	-	no_errors	GPR98	HGNC	ENSG00000164199	tier1	-	-	46	0	0.00	34	14	29.17	120	0	0.00	76	26	25.49
ENSG00000235837	0	genome.wustl.edu	37	7	16737659	16737659	+	R	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	7	16737659	16737659	C	T	SNP	ENSG00000235837	ENST00000418907	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	AC073333.8	Clone_based_vega_gene	ENSG00000235837	tier1	-	-	35	0	0.00	18	8	30.77	73	0	0.00	34	28	44.44
TP53	0	genome.wustl.edu	37	17	7578204	7578204	+	Missense_Mutation	SNP	A	A	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	17	7578204	7578204	A	C	SNP	TP53	ENST00000269305	human	ensembl	74_37	-1	known	missense	c.645	p.S215R	0.959	pfam_p53_D-bd,superfamily_p53-like_TF_D-bd,prints_p53_tumour_suppressor	pfam_p53_D-bd,pfam_p53_tetrameristn,pfam_p53_transactivation_domain,superfamily_p53-like_TF_D-bd,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	-	no_errors	TP53	HGNC	ENSG00000141510	tier1	-	-	66	0	0.00	16	45	72.58	120	0	0.00	23	48	67.61
CDON	0	genome.wustl.edu	37	11	125867223	125867223	+	Silent	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	125867223	125867223	C	G	SNP	CDON	ENST00000392693	human	ensembl	74_37	-1	known	silent	c.2241	p.G747	0.953	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	CDON	HGNC	ENSG00000064309	tier1	-	-	118	0	0.00	44	27	38.03	89	0	0.00	48	12	20.00
FGG	0	genome.wustl.edu	37	4	155526029	155526029	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	4	155526029	155526029	G	A	SNP	FGG	ENST00000336098	human	ensembl	74_37	-1	known	missense	c.1319	p.A440V	0.000	NULL	pfam_Fibrinogen_a/b/g_C_dom,pfam_Fibrinogen_a/b/g_coil_dom,superfamily_Fibrinogen_a/b/g_C_dom,smart_Fibrinogen_a/b/g_C_dom	-	no_errors	FGG	HGNC	ENSG00000171557	tier1	rs141597421	-	76	0	0.00	75	14	15.73	118	0	0.00	126	20	13.70
YME1L1	0	genome.wustl.edu	37	10	27403538	27403538	+	Splice_Site	SNP	T	T	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	10	27403538	27403538	T	C	SNP	YME1L1	ENST00000326799	human	ensembl	74_37	-1	known	splice_site	c.2092-2	e19-2	1.000	-	-	-	no_errors	YME1L1	HGNC	ENSG00000136758	tier1	-	-	67	0	0.00	38	7	15.56	153	0	0.00	71	11	13.25
ZZZ3	0	genome.wustl.edu	37	1	78031848	78031848	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	78031848	78031848	C	T	SNP	ZZZ3	ENST00000370801	human	ensembl	74_37	-1	known	missense	c.2485	p.E829K	1.000	pfam_Znf_ZZ,pfscan_Znf_ZZ	pfam_SANT/Myb,pfam_Znf_ZZ,superfamily_Homeodomain-like,smart_SANT/Myb,pfscan_Znf_ZZ,pfscan_Myb-like_dom	-	no_errors	ZZZ3	HGNC	ENSG00000036549	tier1	-	-	113	0	0.00	107	18	14.40	92	0	0.00	103	29	21.97
SSH3	0	genome.wustl.edu	37	11	67075346	67075346	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	67075346	67075346	C	T	SNP	SSH3	ENST00000308127	human	ensembl	74_37	+1	known	missense	c.821	p.A274V	0.969	pfam_DEK_C	pfam_Dual-sp_phosphatase_cat-dom,pfam_DEK_C,smart_Dual-sp_phosphatase_subgr_cat,pfscan_Tyr/Dual-sp_Pase,pfscan_Dual-sp_phosphatase_subgr_cat	-	no_errors	SSH3	HGNC	ENSG00000172830	tier1	-	-	52	0	0.00	47	17	26.56	70	0	0.00	63	24	27.59
KIF1A	0	genome.wustl.edu	37	2	241700664	241700664	+	Missense_Mutation	SNP	G	G	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	2	241700664	241700664	G	C	SNP	KIF1A	ENST00000498729	human	ensembl	74_37	-1	known	missense	c.2247	p.S749R	0.996	NULL	pfam_Kinesin_motor_dom,pfam_Kinesin-like,pfam_Pleckstrin_homology,pfam_KIF1B,pfam_FHA_dom,superfamily_P-loop_NTPase,superfamily_SMAD_FHA_domain,smart_Kinesin_motor_dom,smart_FHA_dom,smart_Pleckstrin_homology,pfscan_FHA_dom,pfscan_Pleckstrin_homology,pfscan_Kinesin_motor_dom,prints_Kinesin_motor_dom	-	no_errors	KIF1A	HGNC	ENSG00000130294	tier1	-	-	20	0	0.00	6	20	76.92	61	0	0.00	18	30	62.50
SYNM	0	genome.wustl.edu	37	15	99670639	99670639	+	Silent	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	15	99670639	99670639	C	T	SNP	SYNM	ENST00000336292	human	ensembl	74_37	+1	known	silent	c.2071	p.L691	0.502	NULL	pfam_IF	-	no_errors	SYNM	HGNC	ENSG00000182253	tier1	-	-	28	0	0.00	3	7	70.00	144	0	0.00	30	22	42.31
DAZL	0	genome.wustl.edu	37	3	16638396	16638396	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	3	16638396	16638396	C	A	SNP	DAZL	ENST00000399444	human	ensembl	74_37	-1	known	missense	c.359	p.C120F	1.000	NULL	pfam_RRM_dom,smart_RRM_dom,pfscan_RRM_dom	-	no_errors	DAZL	HGNC	ENSG00000092345	tier1	-	-	231	0	0.00	143	114	44.36	79	0	0.00	52	24	31.58
PKHD1L1	0	genome.wustl.edu	37	8	110516561	110516561	+	Missense_Mutation	SNP	A	A	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	8	110516561	110516561	A	C	SNP	PKHD1L1	ENST00000378402	human	ensembl	74_37	+1	known	missense	c.10834	p.T3612P	0.996	NULL	pfam_IPT,pfam_G8_domain,pfam_PA14,superfamily_Ig_E-set,superfamily_Pectin_lyase_fold/virulence,superfamily_Cupredoxin,smart_IPT,smart_PA14,smart_PbH1	-	no_errors	PKHD1L1	HGNC	ENSG00000205038	tier1	-	-	66	0	0.00	24	12	33.33	87	0	0.00	55	19	25.68
GPAA1	0	genome.wustl.edu	37	8	145139735	145139735	+	Missense_Mutation	SNP	A	A	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	8	145139735	145139735	A	G	SNP	GPAA1	ENST00000355091	human	ensembl	74_37	+1	known	missense	c.1121	p.Y374C	1.000	pfam_Gaa1,pirsf_GPI_prot_transamidse_cplx_GAA1	pfam_Gaa1,pirsf_GPI_prot_transamidse_cplx_GAA1	-	no_errors	GPAA1	HGNC	ENSG00000197858	tier1	-	-	30	0	0.00	26	8	23.53	61	0	0.00	43	17	28.33
SLC26A9	0	genome.wustl.edu	37	1	205892290	205892290	+	Missense_Mutation	SNP	T	T	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	205892290	205892290	T	G	SNP	SLC26A9	ENST00000340781	human	ensembl	74_37	-1	known	missense	c.1693	p.K565Q	1.000	pfam_STAS_dom,superfamily_STAS_dom,pfscan_STAS_dom,tigrfam_SulP_transpt	pfam_Sulph_transpt,pfam_STAS_dom,superfamily_STAS_dom,pfscan_STAS_dom,tigrfam_SulP_transpt	-	no_errors	SLC26A9	HGNC	ENSG00000174502	tier1	-	-	51	0	0.00	10	15	60.00	69	0	0.00	10	34	77.27
ZZZ3	0	genome.wustl.edu	37	1	78031803	78031803	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	78031803	78031803	C	G	SNP	ZZZ3	ENST00000370801	human	ensembl	74_37	-1	known	missense	c.2530	p.E844Q	1.000	pfam_Znf_ZZ,pfscan_Znf_ZZ	pfam_SANT/Myb,pfam_Znf_ZZ,superfamily_Homeodomain-like,smart_SANT/Myb,pfscan_Znf_ZZ,pfscan_Myb-like_dom	-	no_errors	ZZZ3	HGNC	ENSG00000036549	tier1	-	-	101	0	0.00	97	18	15.52	103	0	0.00	102	37	26.62
CHR4	0	genome.wustl.edu	37	20	61982044	61982044	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	20	61982044	61982044	C	T	SNP	CHR4	ENST00000370263	human	ensembl	74_37	-1	known	missense	c.719	p.R240Q	1.000	pfam_Neur_chan_lig-bd,superfamily_Neur_chan_lig-bd,prints_Neur_channel,tigrfam_Neur_channel	pfam_Neurotrans-gated_channel_TM,pfam_Neur_chan_lig-bd,superfamily_Neurotrans-gated_channel_TM,superfamily_Neur_chan_lig-bd,prints_Nicotinic_acetylcholine_rcpt,prints_Neur_channel,tigrfam_Neur_channel	-	no_errors	CHR4	HGNC	ENSG00000101204	tier1	rs78695425	-	27	0	0.00	17	10	37.04	20	0	0.00	22	3	12.00
ZZZ3	0	genome.wustl.edu	37	1	78030187	78030187	+	R	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	78030187	78030187	C	G	SNP	ZZZ3	ENST00000481346	human	ensembl	74_37	-1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	ZZZ3	HGNC	ENSG00000036549	tier1	-	-	55	0	0.00	37	12	24.49	88	0	0.00	79	27	25.47
KLC3	0	genome.wustl.edu	37	19	45851923	45851923	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	19	45851923	45851923	G	A	SNP	KLC3	ENST00000470402	human	ensembl	74_37	+1	known	missense	c.841	p.E281K	1.000	smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom	pfam_Rabaptin_Rab5-bd_dom,pfam_TPR_1,smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom,prints_Kinesin_light	-	no_errors	KLC3	HGNC	ENSG00000104892	tier1	-	-	81	0	0.00	74	30	28.85	70	0	0.00	69	22	24.18
WDR36	0	genome.wustl.edu	37	5	110438084	110438084	+	Missense_Mutation	SNP	A	A	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	5	110438084	110438084	A	G	SNP	WDR36	ENST00000506538	human	ensembl	74_37	+1	known	missense	c.751	p.T251A	1.000	superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat_dom	pfam_SSU_processome_Utp21,pfam_WD40_repeat,superfamily_Quinonprotein_ADH-like_supfam,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	WDR36	HGNC	ENSG00000134987	tier1	-	-	140	0	0.00	89	29	24.58	112	0	0.00	53	27	33.75
MYRIP	0	genome.wustl.edu	37	3	40231809	40231809	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	3	40231809	40231809	C	T	SNP	MYRIP	ENST00000302541	human	ensembl	74_37	+1	known	missense	c.1520	p.T507I	1.000	pfam_Myrip/Melanophilin	pfam_Myrip/Melanophilin,superfamily_Znf_FYVE_PHD,pfscan_Znf_FYVE-typ	-	no_errors	MYRIP	HGNC	ENSG00000170011	tier1	-	-	24	0	0.00	23	20	46.51	23	0	0.00	24	9	27.27
CDK5RAP3	0	genome.wustl.edu	37	17	46058946	46058946	+	R	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	17	46058946	46058946	C	T	SNP	CDK5RAP3	ENST00000578663	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	CDK5RAP3	HGNC	ENSG00000108465	tier1	-	-	50	0	0.00	34	12	26.09	70	0	0.00	23	12	34.29
CCKBR	0	genome.wustl.edu	37	11	6292222	6292222	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	6292222	6292222	G	A	SNP	CCKBR	ENST00000525462	human	ensembl	74_37	+1	known	missense	c.1000	p.A334T	0.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Gastrin_rcpt,prints_Cholcskin_rcpt,prints_GPCR_Rhodpsn,prints_NPY_rcpt	-	no_errors	CCKBR	HGNC	ENSG00000110148	tier1	rs200830731	-	44	0	0.00	14	11	44.00	45	0	0.00	21	14	40.00
AKR1CL1	0	genome.wustl.edu	37	10	5199959	5199959	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	10	5199959	5199959	C	G	SNP	AKR1CL1	ENST00000473890	human	ensembl	74_37	-1	novel	missense	c.207	p.L69F	0.000	pfam_DP_OxRdtase_dom,superfamily_DP_OxRdtase_dom,prints_Aldo/keto_reductase_subgr	pfam_DP_OxRdtase_dom,superfamily_DP_OxRdtase_dom,prints_Aldo/keto_reductase_subgr	-	no_errors	AKR1CL1	HGNC	ENSG00000196326	tier1	-	-	83	0	0.00	69	12	14.81	61	0	0.00	45	15	25.00
SORBS1	0	genome.wustl.edu	37	10	97131754	97131754	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	10	97131754	97131754	C	G	SNP	SORBS1	ENST00000361941	human	ensembl	74_37	-1	known	missense	c.1790	p.R597T	1.000	NULL	pfam_SH3_domain,pfam_SH3_2,pfam_Sorb,superfamily_SH3_domain,smart_Sorb,smart_SH3_domain,pfscan_Sorb,pfscan_SH3_domain	-	no_errors	SORBS1	HGNC	ENSG00000095637	tier1	-	-	42	0	0.00	15	13	46.43	87	0	0.00	28	23	45.10
BLNK	0	genome.wustl.edu	37	10	97951794	97951794	+	Missense_Mutation	SNP	G	G	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	10	97951794	97951794	G	C	SNP	BLNK	ENST00000224337	human	ensembl	74_37	-1	known	missense	c.1306	p.L436V	1.000	pfscan_SH2	pfam_SH2,smart_SH2,pfscan_SH2	-	no_errors	BLNK	HGNC	ENSG00000095585	tier1	-	-	102	0	0.00	49	15	23.44	123	0	0.00	59	9	13.24
ANKRD18A	0	genome.wustl.edu	37	9	38596278	38596278	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	9	38596278	38596278	C	G	SNP	ANKRD18A	ENST00000399703	human	ensembl	74_37	-1	known	missense	c.1059	p.K353N	0.809	NULL	pfam_DUF3496,pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom	-	no_errors	ANKRD18A	HGNC	ENSG00000180071	tier1	-	-	49	0	0.00	40	24	37.50	23	0	0.00	11	3	21.43
AGAP3	0	genome.wustl.edu	37	7	150784064	150784064	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	7	150784064	150784064	T	A	SNP	AGAP3	ENST00000397238	human	ensembl	74_37	+1	known	missense	c.236	p.V79E	1.000	NULL	pfam_ArfGAP,pfam_MIRO-like,pfam_Small_GTPase,pfam_Pleckstrin_homology,superfamily_P-loop_NTPase,superfamily_Ankyrin_rpt-contain_dom,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Pleckstrin_homology,smart_ArfGAP,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,pfscan_Pleckstrin_homology,pfscan_ArfGAP,prints_ArfGAP,prints_Small_GTPase	-	no_errors	AGAP3	HGNC	ENSG00000133612	tier1	-	-	38	0	0.00	11	4	26.67	27	0	0.00	20	9	31.03
DAGLA	0	genome.wustl.edu	37	11	61508747	61508747	+	Silent	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	61508747	61508747	C	G	SNP	DAGLA	ENST00000257215	human	ensembl	74_37	+1	known	silent	c.2097	p.L699	1.000	NULL	pfam_Lipase_3	-	no_errors	DAGLA	HGNC	ENSG00000134780	tier1	-	-	41	0	0.00	58	29	33.33	13	0	0.00	14	3	17.65
BCAS3	0	genome.wustl.edu	37	17	59104259	59104260	+	Frame_Shift_Ins	INS	-	-	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	-	-	-	A	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	17	59104259	59104260	-	A	INS	BCAS3	ENST00000390652	human	ensembl	74_37	+1	known	frame_shift_ins	c.1670_1671	p.A559fs	1.000:1.000	pfam_BCAS3	pfam_BCAS3,pfam_WD40_repeat	-	no_errors	BCAS3	HGNC	ENSG00000141376	tier1			110	0	0.00	34	17	33.33	117	0	0.00	54	23	29.87
ZNF234	0	genome.wustl.edu	37	19	44661690	44661691	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	AG	AG	AG	-	AG	AG	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	19	44661690	44661691	AG	-	DEL	ZNF234	ENST00000426739	human	ensembl	74_37	+1	known	frame_shift_del	c.1521_1522	p.K510fs	0.360:0.998	pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF234	HGNC	ENSG00000263002	tier1			83	0	0.00	83	34	29.06	26	0	0.00	32	5	13.51
CSPG4	0	genome.wustl.edu	37	15	75979836	75979836	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	15	75979836	75979836	C	G	SNP	CSPG4	ENST00000308508	human	ensembl	74_37	-1	known	missense	c.3570	p.Q1190H	1.000	NULL	pfam_Laminin_G,superfamily_ConA-like_lec_gl_sf,smart_Laminin_G,pfscan_Laminin_G	-	no_errors	CSPG4	HGNC	ENSG00000173546	tier1	-	-	99	0	0.00	38	47	55.29	22	0	0.00	6	8	57.14
JPH2	0	genome.wustl.edu	37	20	42789014	42789014	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	20	42789014	42789014	C	T	SNP	JPH2	ENST00000372980	human	ensembl	74_37	-1	known	missense	c.413	p.R138H	1.000	pfam_MORN,smart_MORN,pirsf_Junctophilin	pfam_MORN,smart_MORN,pirsf_Junctophilin	-	no_errors	JPH2	HGNC	ENSG00000149596	tier1	-	-	76	0	0.00	32	56	63.64	10	0	0.00	3	7	70.00
NOBOX	0	genome.wustl.edu	37	7	144096231	144096231	+	Silent	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	7	144096231	144096231	G	A	SNP	NOBOX	ENST00000467773	human	ensembl	74_37	-1	known	silent	c.1281	p.P427	0.000	NULL	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom	-	no_errors	NOBOX	HGNC	ENSG00000106410	tier1	-	-	89	0	0.00	43	61	58.65	9	0	0.00	0	4	100.00
NUDT10	0	genome.wustl.edu	37	X	51075934	51075934	+	Silent	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	X	51075934	51075934	C	T	SNP	NUDT10	ENST00000356450	human	ensembl	74_37	+1	known	silent	c.117	p.S39	0.980	pfam_NUDIX_hydrolase_dom,superfamily_NUDIX_hydrolase_dom-like	pfam_NUDIX_hydrolase_dom,superfamily_NUDIX_hydrolase_dom-like	-	no_errors	NUDT10	HGNC	ENSG00000122824	tier1	-	-	153	0	0.00	29	110	78.57	34	0	0.00	7	22	75.86
PRDM16	0	genome.wustl.edu	37	1	3328332	3328332	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	3328332	3328332	C	A	SNP	PRDM16	ENST00000270722	human	ensembl	74_37	+1	known	missense	c.1571	p.P524H	1.000	NULL	pfam_Znf_C2H2,pfam_Znf_BED_prd,smart_SET_dom,smart_Znf_C2H2-like,pfscan_SET_dom,pfscan_Znf_C2H2	-	no_errors	PRDM16	HGNC	ENSG00000142611	tier1	-	-	74	0	0.00	13	41	75.93	23	0	0.00	1	13	86.67
TH	0	genome.wustl.edu	37	11	2189744	2189744	+	Missense_Mutation	SNP	A	A	C			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	2189744	2189744	A	C	SNP	TH	ENST00000381178	human	ensembl	74_37	-1	known	missense	c.557	p.V186G	0.999	pirsf_Tyrosine_3-monooxygenase-like,tigrfam_Tyr_3_mOase	pfam_Aromatic-AA_hydroxylase_C,pfam_Tyrosine_hydroxylase_CS,superfamily_Aromatic-AA_hydroxylase_C,pirsf_Tyrosine_3-monooxygenase-like,prints_Aromatic-AA_hydroxylase_C,tigrfam_Tyr_3_mOase	-	no_errors	TH	HGNC	ENSG00000180176	tier1	-	-	40	0	0.00	7	14	66.67	23	0	0.00	6	16	72.73
BLNK	0	genome.wustl.edu	37	10	97951812	97951812	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	10	97951812	97951812	G	A	SNP	BLNK	ENST00000224337	human	ensembl	74_37	-1	known	nonsense	c.1288	p.Q430*	1.000	smart_SH2,pfscan_SH2	pfam_SH2,smart_SH2,pfscan_SH2	-	no_errors	BLNK	HGNC	ENSG00000095585	tier1	-	-	105	0	0.00	48	14	22.58	125	0	0.00	58	6	9.38
LRRC30	0	genome.wustl.edu	37	18	7231877	7231877	+	Silent	SNP	C	C	A			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	18	7231877	7231877	C	A	SNP	LRRC30	ENST00000383467	human	ensembl	74_37	+1	known	silent	c.741	p.L247	0.196	pfam_Leu-rich_rpt,smart_Leu-rich_rpt_typical-subtyp	pfam_Leu-rich_rpt,smart_Leu-rich_rpt_typical-subtyp	-	no_errors	LRRC30	HGNC	ENSG00000206422	tier1	-	-	49	0	0.00	33	4	10.81	75	0	0.00	77	6	7.23
DGKG	0	genome.wustl.edu	37	3	185867916	185867916	+	Missense_Mutation	SNP	A	A	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	3	185867916	185867916	A	G	SNP	DGKG	ENST00000265022	human	ensembl	74_37	-1	known	missense	c.2339	p.F780S	1.000	NULL	pfam_Diacylglycerol_kin_accessory,pfam_Diacylglycerol_kinase_cat_dom,pfam_Prot_Kinase_C-like_PE/DAG-bd,smart_EF_hand_dom,smart_Prot_Kinase_C-like_PE/DAG-bd,smart_Diacylglycerol_kinase_cat_dom,smart_Diacylglycerol_kin_accessory,pfscan_EF_hand_dom,pfscan_Prot_Kinase_C-like_PE/DAG-bd	-	no_errors	DGKG	HGNC	ENSG00000058866	tier1	-	-	44	0	0.00	33	14	29.79	72	0	0.00	66	7	9.59
TGM3	0	genome.wustl.edu	37	20	2298099	2298099	+	Silent	SNP	A	A	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	20	2298099	2298099	A	G	SNP	TGM3	ENST00000381458	human	ensembl	74_37	+1	known	silent	c.951	p.G317	0.088	pfam_Transglutaminase-like,smart_Transglutaminase-like	pfam_Transglutaminase_C,pfam_Transglutaminase_N,pfam_Transglutaminase-like,superfamily_Ig_E-set,superfamily_Transglutaminase_C,smart_Transglutaminase-like	-	no_errors	TGM3	HGNC	ENSG00000125780	tier1	-	-	75	0	0.00	47	6	11.32	111	0	0.00	101	9	8.18
AHK	0	genome.wustl.edu	37	11	62284533	62284534	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	CA	CA	CA	-	CA	CA	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	62284533	62284534	CA	-	DEL	AHK	ENST00000378024	human	ensembl	74_37	-1	known	frame_shift_del	c.17356_17355	p.D5785fs	0.975:0.440	NULL	superfamily_PDZ,smart_PDZ,pfscan_PDZ	-	no_errors	AHK	HGNC	ENSG00000124942	tier1			37	0	0.00	15	9	37.50	81	0	0.00	73	4	5.19
UGT3A2	0	genome.wustl.edu	37	5	36039752	36039752	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	5	36039752	36039752	C	T	SNP	UGT3A2	ENST00000282507	human	ensembl	74_37	-1	known	missense	c.902	p.G301D	0.999	pfam_UDP_glucos_trans	pfam_UDP_glucos_trans,pfam_Glyco_trans_28_C	-	no_errors	UGT3A2	HGNC	ENSG00000168671	tier1	-	-	66	0	0.00	68	19	21.84	173	2	1.14	174	37	17.45
DPP6	0	genome.wustl.edu	37	7	154667715	154667715	+	Silent	SNP	C	C	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	7	154667715	154667715	C	T	SNP	DPP6	ENST00000377770	human	ensembl	74_37	+1	known	silent	c.1983	p.D661	0.989	pfam_Peptidase_S9	pfam_Peptidase_S9B,pfam_Peptidase_S9,pfam_PD40	-	no_errors	DPP6	HGNC	ENSG00000130226	tier1	-	-	125	0	0.00	75	18	19.35	35	1	2.78	18	11	37.93
RBMS1	0	genome.wustl.edu	37	2	161130978	161130982	+	R	DEL	TTTTC	TTTTC	-			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	TTTTC	TTTTC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	2	161130978	161130982	TTTTC	-	DEL	RBMS1	ENST00000474820	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.008:0.121:0.138:0.129:0.057	-	-	-	no_errors	RBMS1	HGNC	ENSG00000153250	tier1			31	0	0.00	6	0	0.00	31	0	0.00	6	0	0.00
RPL23AP79	0	genome.wustl.edu	37	19	59110563	59110563	+	R	SNP	C	C	G			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	19	59110563	59110563	C	G	SNP	RPL23AP79	ENST00000473164	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	RPL23AP79	HGNC	ENSG00000213753	tier1	-	-	16	0	0.00	5	8	61.54	0	0	0.00	0	0	0.00
CSMD2	0	genome.wustl.edu	37	1	34401431	34401431	+	Missense_Mutation	SNP	G	G	T			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	1	34401431	34401431	G	T	SNP	CSMD2	ENST00000373381	human	ensembl	74_37	-1	known	missense	c.642	p.H214Q	0.971	pfam_Sushi_SCR_CCP,superfamily_Sushi_SCR_CCP,smart_Sushi_SCR_CCP,pfscan_Sushi_SCR_CCP	pfam_CUB_dom,pfam_Sushi_SCR_CCP,superfamily_CUB_dom,superfamily_Sushi_SCR_CCP,smart_CUB_dom,smart_Sushi_SCR_CCP,pfscan_CUB_dom,pfscan_Sushi_SCR_CCP	-	no_errors	CSMD2	HGNC	ENSG00000121904	tier1	-	-	35	0	0.00	28	4	12.50	25	0	0.00	43	2	4.44
AHK	0	genome.wustl.edu	37	11	62284538	62284571	+	Frame_Shift_Del	DEL	CTGAATGAATTTGAGCGGTGCCGTGGCTTCTTAC	CTGAATGAATTTGAGCGGTGCCGTGGCTTCTTAC	-			TCGA-K1-A6RV-01A-11D-A32I-09	TCGA-K1-A6RV-10A-01D-A32I-09	CTGAATGAATTTGAGCGGTGCCGTGGCTTCTTAC	CTGAATGAATTTGAGCGGTGCCGTGGCTTCTTAC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	fde49939-fe43-4058-b143-4997914ebfe9	f92cf376-b51a-4720-bd93-faed5da32efb	11	62284538	62284571	CTGAATGAATTTGAGCGGTGCCGTGGCTTCTTAC	-	DEL	AHK	ENST00000378024	human	ensembl	74_37	-1	known	frame_shift_del	c.17351_17318	p.S5773fs	0.998:1.000:1.000:1.000:0.996:0.924:0.938:0.929:0.002:0.000:0.000:0.000:0.970:0.982:0.960:0.999:1.000:1.000:0.995:0.929:0.283:0.192:0.069:0.024:0.956:0.961:1.000:1.000:1.000:0.992:0.992:0.893:0.822:0.918	NULL	superfamily_PDZ,smart_PDZ,pfscan_PDZ	-	no_errors	AHK	HGNC	ENSG00000124942	tier1			80	0	0.00	73	3	3.95	80	0	0.00	73	3	3.95