Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
FLT4	0	genome.wustl.edu	37	5	180047285	180047285	+	Silent	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	5	180047285	180047285	C	T	SNP	FLT4	ENST00000261937	human	ensembl	74_37	-1	known	silent	c.2430	p.T810	0.029	superfamily_Kinase-like_dom	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_Ig_I-set,superfamily_Kinase-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom,prints_VEGFR3_rcpt	-	no_errors	FLT4	HGNC	ENSG00000037280	tier1	rs143907746	GMAF=0.0005	102	0	0.00	48	7	12.73	19	0	0.00	23	9	28.12
APC1	0	genome.wustl.edu	37	2	112615924	112615924	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	2	112615924	112615924	T	A	SNP	APC1	ENST00000341068	human	ensembl	74_37	-1	known	missense	c.1317	p.Q439H	0.748	NULL	NULL	-	no_errors	APC1	HGNC	ENSG00000153107	tier1	-	-	257	0	0.00	93	28	22.95	33	0	0.00	27	4	12.90
RB1	0	genome.wustl.edu	37	13	48947579	48947579	+	Nonsense_Mutation	SNP	T	T	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	13	48947579	48947579	T	G	SNP	RB1	ENST00000267163	human	ensembl	74_37	+1	known	nonsense	c.1166	p.L389*	1.000	pfam_RB_A,superfamily_Cyclin-like	pfam_RB_C,pfam_RB_A,pfam_RB_B,pfam_RB_N,superfamily_Cyclin-like,smart_Cyclin-like	-	no_errors	RB1	HGNC	ENSG00000139687	tier1	-	-	38	0	0.00	6	8	57.14	91	0	0.00	45	25	35.71
SORL1	0	genome.wustl.edu	37	11	121429444	121429444	+	Silent	SNP	G	G	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	11	121429444	121429444	G	A	SNP	SORL1	ENST00000260197	human	ensembl	74_37	+1	known	silent	c.2808	p.T936	0.005	smart_LDLR_classB_rpt,pfscan_LDLR_classB_rpt	pfam_LDrepeatLR_classA_rpt,pfam_Fibronectin_type3,pfam_LDLR_classB_rpt,superfamily_Fibronectin_type3,superfamily_LDrepeatLR_classA_rpt,smart_VPS10,smart_LDLR_classB_rpt,smart_LDrepeatLR_classA_rpt,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_LDrepeatLR_classA_rpt,pfscan_LDLR_classB_rpt,prints_LDrepeatLR_classA_rpt	-	no_errors	SORL1	HGNC	ENSG00000137642	tier1	-	-	54	0	0.00	26	4	13.33	66	1	1.47	48	20	29.41
YRDC	0	genome.wustl.edu	37	1	38269624	38269624	+	Silent	SNP	C	C	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	1	38269624	38269624	C	A	SNP	YRDC	ENST00000373044	human	ensembl	74_37	-1	known	silent	c.813	p.L271	0.132	NULL	pfam_YrdC-like_dom,superfamily_DHBP_synth_RibB-like_a/b_dom,pfscan_YrdC-like_dom,tigrfam_YrdC-like_dom	-	no_errors	YRDC	HGNC	ENSG00000196449	tier1	-	-	88	0	0.00	41	18	30.51	122	0	0.00	141	45	24.19
ABHD10	0	genome.wustl.edu	37	3	111709558	111709558	+	Missense_Mutation	SNP	G	G	C			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	3	111709558	111709558	G	C	SNP	ABHD10	ENST00000494817	human	ensembl	74_37	+1	putative	missense	c.588	p.R196S	0.103	NULL	pfam_AB_hydrolase_1	-	no_errors	ABHD10	HGNC	ENSG00000144827	tier1	-	-	58	0	0.00	31	7	18.42	109	0	0.00	87	37	29.84
CXADR	0	genome.wustl.edu	37	21	18937978	18937978	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	21	18937978	18937978	C	G	SNP	CXADR	ENST00000284878	human	ensembl	74_37	+1	known	missense	c.1066	p.P356A	1.000	NULL	pfam_Ig_V-set,pfam_Ig_I-set,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,pfscan_Ig-like_dom	-	no_errors	CXADR	HGNC	ENSG00000154639	tier1	-	-	84	0	0.00	30	20	40.00	11	0	0.00	15	5	25.00
CLDN24	0	genome.wustl.edu	37	4	184243470	184243470	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	4	184243470	184243470	T	A	SNP	CLDN24	ENST00000541814	human	ensembl	74_37	-1	known	missense	c.110	p.N37I	0.986	pfam_PMP22/EMP/MP20/Claudin	pfam_PMP22/EMP/MP20/Claudin,prints_Claudin	-	no_errors	CLDN24	HGNC	ENSG00000185758	tier1	-	-	94	0	0.00	52	11	17.46	56	0	0.00	94	22	18.97
HOOK1	0	genome.wustl.edu	37	1	60333955	60333955	+	Missense_Mutation	SNP	G	G	C			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	1	60333955	60333955	G	C	SNP	HOOK1	ENST00000371208	human	ensembl	74_37	+1	known	missense	c.1879	p.A627P	1.000	pfam_Hook-related_fam	pfam_Hook-related_fam,superfamily_Prefoldin	-	no_errors	HOOK1	HGNC	ENSG00000134709	tier1	-	-	126	0	0.00	58	26	30.59	73	0	0.00	112	49	30.25
CXADR	0	genome.wustl.edu	37	21	18937853	18937853	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	21	18937853	18937853	C	G	SNP	CXADR	ENST00000284878	human	ensembl	74_37	+1	known	missense	c.941	p.S314C	1.000	NULL	pfam_Ig_V-set,pfam_Ig_I-set,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,pfscan_Ig-like_dom	-	no_errors	CXADR	HGNC	ENSG00000154639	tier1	-	-	89	0	0.00	40	16	28.57	21	0	0.00	29	16	35.56
NPHS1	0	genome.wustl.edu	37	19	36322588	36322588	+	Silent	SNP	G	G	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	19	36322588	36322588	G	A	SNP	NPHS1	ENST00000378910	human	ensembl	74_37	-1	known	silent	c.3243	p.V1081	0.000	NULL	pfam_CD80_C2-set,pfam_Ig_I-set,pfam_Ig_V-set,pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	NPHS1	HGNC	ENSG00000161270	tier1	-	-	54	0	0.00	33	10	23.26	26	0	0.00	17	12	41.38
PIKFYVE	0	genome.wustl.edu	37	2	209141504	209141504	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	2	209141504	209141504	C	T	SNP	PIKFYVE	ENST00000264380	human	ensembl	74_37	+1	known	missense	c.391	p.L131F	1.000	NULL	pfam_PInositol-4-P-5-kinase_core,pfam_Cpn60/TCP-1,pfam_DEP_dom,pfam_Znf_FYVE,superfamily_GroEL-like_apical_dom,superfamily_Znf_FYVE_PHD,smart_Znf_FYVE,smart_DEP_dom,smart_PInositol-4P-5-kinase_core_sub,pfscan_DEP_dom,pfscan_Znf_FYVE-rel	-	no_errors	PIKFYVE	HGNC	ENSG00000115020	tier1	-	-	71	0	0.00	21	7	25.00	98	0	0.00	72	30	29.41
IRS1	0	genome.wustl.edu	37	2	227662246	227662246	+	Silent	SNP	G	G	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	2	227662246	227662246	G	A	SNP	IRS1	ENST00000305123	human	ensembl	74_37	-1	known	silent	c.1209	p.T403	0.797	NULL	pfam_Insln_rcpt_S1,pfam_Pleckstrin_homology,smart_Pleckstrin_homology,smart_Insln_rcpt_S1,prints_Insln_rcpt_S1,pfscan_Pleckstrin_homology,pfscan_Insln_rcpt_S1	-	no_errors	IRS1	HGNC	ENSG00000169047	tier1	-	-	69	0	0.00	33	5	13.16	29	0	0.00	31	14	31.11
XPO1	0	genome.wustl.edu	37	2	61726902	61726902	+	Missense_Mutation	SNP	A	A	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	2	61726902	61726902	A	G	SNP	XPO1	ENST00000401558	human	ensembl	74_37	-1	known	missense	c.536	p.F179S	1.000	pfam_Exportin-1/Importin-b-like,superfamily_ARM-type_fold	pfam_CRM1_C_dom,pfam_Exportin-1/Importin-b-like,pfam_Importin-beta_N,superfamily_ARM-type_fold,smart_Importin-beta_N,pfscan_Importin-beta_N	-	no_errors	XPO1	HGNC	ENSG00000082898	tier1	-	-	63	0	0.00	20	14	41.18	88	0	0.00	67	44	39.64
TMPRSS15	0	genome.wustl.edu	37	21	19647612	19647612	+	Silent	SNP	G	G	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	21	19647612	19647612	G	A	SNP	TMPRSS15	ENST00000284885	human	ensembl	74_37	-1	known	silent	c.2806	p.L936	0.191	pfam_Peptidase_S1,pfam_Peptidase_S1A_nudel,superfamily_Trypsin-like_Pept_dom,smart_Peptidase_S1,pfscan_Peptidase_S1	pfam_Peptidase_S1,pfam_CUB_dom,pfam_MAM_dom,pfam_SEA_dom,pfam_LDrepeatLR_classA_rpt,pfam_Peptidase_S1A_nudel,pfam_SRCR,superfamily_Trypsin-like_Pept_dom,superfamily_ConA-like_lec_gl_sf,superfamily_CUB_dom,superfamily_LDrepeatLR_classA_rpt,superfamily_Srcr_rcpt-rel,smart_SEA_dom,smart_LDrepeatLR_classA_rpt,smart_CUB_dom,smart_MAM_dom,smart_Srcr_rcpt-rel,smart_Peptidase_S1,pfscan_CUB_dom,pfscan_LDrepeatLR_classA_rpt,pfscan_MAM_dom,pfscan_SEA_dom,pfscan_SRCR,pfscan_Peptidase_S1,prints_Peptidase_S1A,prints_LDrepeatLR_classA_rpt	-	no_errors	TMPRSS15	HGNC	ENSG00000154646	tier1	-	-	63	0	0.00	19	9	32.14	55	0	0.00	54	14	20.59
ZNF160	0	genome.wustl.edu	37	19	53576670	53576670	+	Silent	SNP	T	T	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	19	53576670	53576670	T	G	SNP	ZNF160	ENST00000355147	human	ensembl	74_37	-1	putative	silent	c.364	p.R122	0.000	NULL	pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,pfscan_Krueppel-associated_box	-	no_errors	ZNF160	HGNC	ENSG00000170949	tier1	-	-	77	0	0.00	62	11	15.07	65	0	0.00	92	12	11.54
UGT8	0	genome.wustl.edu	37	4	115585186	115585186	+	Silent	SNP	T	T	C			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	4	115585186	115585186	T	C	SNP	UGT8	ENST00000310836	human	ensembl	74_37	+1	known	silent	c.858	p.H286	0.978	pfam_UDP_glucos_trans	pfam_UDP_glucos_trans,pfam_Glyco_trans_28_C	-	no_errors	UGT8	HGNC	ENSG00000174607	tier1	-	-	71	0	0.00	27	13	32.50	118	0	0.00	113	59	34.10
TBCE	0	genome.wustl.edu	37	1	235577820	235577820	+	Silent	SNP	G	G	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	1	235577820	235577820	G	A	SNP	TBCE	ENST00000543662	human	ensembl	74_37	+1	known	silent	c.258	p.K86	0.994	superfamily_CAP-Gly_domain	pfam_CAP-Gly_domain,pfam_Ribosomal_S21e,superfamily_CAP-Gly_domain,pfscan_CAP-Gly_domain	-	no_errors	TBCE	HGNC	ENSG00000116957	tier1	-	-	70	0	0.00	56	6	9.68	111	1	0.89	117	20	14.49
MROH2B	0	genome.wustl.edu	37	5	41017989	41017989	+	Silent	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	5	41017989	41017989	C	T	SNP	MROH2B	ENST00000399564	human	ensembl	74_37	-1	known	silent	c.2847	p.A949	0.371	superfamily_ARM-type_fold	superfamily_ARM-type_fold	-	no_errors	MROH2B	HGNC	ENSG00000171495	tier1	-	-	65	0	0.00	50	14	21.54	48	0	0.00	96	26	21.31
RALGPS2	0	genome.wustl.edu	37	1	178854229	178854229	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	1	178854229	178854229	C	G	SNP	RALGPS2	ENST00000367635	human	ensembl	74_37	+1	known	missense	c.923	p.S308C	1.000	NULL	pfam_RasGRF_CDC25,superfamily_Ras_GEF_dom,smart_RasGRF_CDC25,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology,pfscan_RasGRF_CDC25	-	no_errors	RALGPS2	HGNC	ENSG00000116191	tier1	-	-	82	0	0.00	76	9	10.59	66	0	0.00	136	20	12.82
THSD7B	0	genome.wustl.edu	37	2	137814609	137814609	+	Silent	SNP	G	G	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	2	137814609	137814609	G	T	SNP	THSD7B	ENST00000272643	human	ensembl	74_37	+1	known	silent	c.759	p.L253	0.998	NULL	pfam_Thrombospondin_1_rpt,superfamily_Thrombospondin_1_rpt,smart_Thrombospondin_1_rpt,pfscan_Thrombospondin_1_rpt	-	no_errors	THSD7B	HGNC	ENSG00000144229	tier1	-	-	75	0	0.00	29	10	25.00	108	0	0.00	76	43	36.13
SHC4	0	genome.wustl.edu	37	15	49127052	49127052	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	15	49127052	49127052	T	A	SNP	SHC4	ENST00000332408	human	ensembl	74_37	-1	known	missense	c.1651	p.S551C	0.998	pfam_SH2,smart_SH2,pfscan_SH2,prints_SH2	pfam_PTB/PI_dom,pfam_SH2,smart_PTB/PI_dom,smart_SH2,pfscan_PTB/PI_dom,pfscan_SH2,prints_PID_Shc-like,prints_SH2	-	no_errors	SHC4	HGNC	ENSG00000185634	tier1	-	-	71	0	0.00	17	8	32.00	103	0	0.00	85	36	29.75
LINC00052	0	genome.wustl.edu	37	15	88121685	88121685	+	R	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	15	88121685	88121685	C	T	SNP	LINC00052	ENST00000560153	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.002	-	-	-	no_errors	LINC00052	HGNC	ENSG00000259527	tier1	-	-	59	0	0.00	26	7	21.21	80	0	0.00	90	17	15.89
LPHN2	0	genome.wustl.edu	37	1	82402483	82402483	+	Missense_Mutation	SNP	A	A	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	1	82402483	82402483	A	G	SNP	LPHN2	ENST00000370717	human	ensembl	74_37	+1	known	missense	c.359	p.Y120C	1.000	pfam_Lectin_gal-bd_dom,pfscan_Lectin_gal-bd_dom	pfam_GPCR_2_latrophilin_rcpt_C,pfam_Olfac-like,pfam_DUF3497,pfam_GPCR_2_secretin-like,pfam_Lectin_gal-bd_dom,pfam_GPS_dom,pfam_GPCR_2_extracellular_dom,smart_Olfac-like,smart_GPCR_2_extracellular_dom,smart_GPS_dom,prints_GPCR_2_latrophilin,prints_GPCR_2_secretin-like,pfscan_GPS_dom,pfscan_Lectin_gal-bd_dom,pfscan_Olfac-like,pfscan_GPCR_2_extracellular_dom,pfscan_GPCR_2-like	-	no_errors	LPHN2	HGNC	ENSG00000117114	tier1	-	-	66	0	0.00	44	9	16.98	124	0	0.00	154	53	25.60
LYNX1	0	genome.wustl.edu	37	8	143846101	143846101	+	Nonsense_Mutation	SNP	G	G	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	8	143846101	143846101	G	T	SNP	LYNX1	ENST00000335822	human	ensembl	74_37	-1	known	nonsense	c.318	p.C106*	0.923	pfam_LY6_UPAR	pfam_LY6_UPAR	-	no_errors	LYNX1	HGNC	ENSG00000180155	tier1	-	-	147	0	0.00	68	27	28.42	38	0	0.00	49	17	25.76
MS4A14	0	genome.wustl.edu	37	11	60165446	60165446	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	11	60165446	60165446	C	A	SNP	MS4A14	ENST00000300187	human	ensembl	74_37	+1	known	missense	c.260	p.A87E	0.652	pfam_CD20-like	pfam_CD20-like	-	no_errors	MS4A14	HGNC	ENSG00000166928	tier1	-	-	41	0	0.00	4	17	80.95	119	0	0.00	78	60	43.48
TOPAZ1	0	genome.wustl.edu	37	3	44303960	44303960	+	Missense_Mutation	SNP	A	A	C			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	3	44303960	44303960	A	C	SNP	TOPAZ1	ENST00000309765	human	ensembl	74_37	+1	known	missense	c.3005	p.Y1002S	0.040	NULL	NULL	-	no_errors	TOPAZ1	HGNC	ENSG00000173769	tier1	-	-	76	0	0.00	21	13	38.24	55	0	0.00	33	18	35.29
CAC1H	0	genome.wustl.edu	37	16	1257370	1257370	+	Silent	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	16	1257370	1257370	C	T	SNP	CAC1H	ENST00000348261	human	ensembl	74_37	+1	known	silent	c.3003	p.F1001	0.997	pfam_Ion_trans_dom	pfam_Ion_trans_dom,pfam_PKD1_2_channel,prints_VDCC_T_a1su,prints_PKD_2	-	no_errors	CAC1H	HGNC	ENSG00000196557	tier1	-	-	24	0	0.00	6	6	50.00	21	0	0.00	21	10	32.26
UNC13C	0	genome.wustl.edu	37	15	54914551	54914551	+	Nonsense_Mutation	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	15	54914551	54914551	C	T	SNP	UNC13C	ENST00000260323	human	ensembl	74_37	+1	known	nonsense	c.6133	p.Q2045*	1.000	superfamily_C2_dom	pfam_Munc13_subgr_dom-2,pfam_Ca-dep_secretion_activator,pfam_C2_dom,pfam_Prot_Kinase_C-like_PE/DAG-bd,superfamily_C2_dom,smart_Prot_Kinase_C-like_PE/DAG-bd,smart_C2_dom,pfscan_C2_dom,pfscan_Prot_Kinase_C-like_PE/DAG-bd,prints_C2_dom	-	no_errors	UNC13C	HGNC	ENSG00000137766	tier1	-	-	27	0	0.00	17	6	26.09	101	0	0.00	105	27	20.45
SCN4B	0	genome.wustl.edu	37	11	118004511	118004511	+	R	SNP	A	A	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	11	118004511	118004511	A	G	SNP	SCN4B	ENST00000423160	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.004	-	-	-	no_errors	SCN4B	HGNC	ENSG00000177098	tier1	-	-	35	0	0.00	6	4	40.00	49	0	0.00	43	15	25.86
CFH	0	genome.wustl.edu	37	1	196709781	196709781	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	1	196709781	196709781	C	T	SNP	CFH	ENST00000367429	human	ensembl	74_37	+1	known	missense	c.2815	p.H939Y	0.000	pfam_Sushi_SCR_CCP,superfamily_Sushi_SCR_CCP,smart_Sushi_SCR_CCP,pfscan_Sushi_SCR_CCP	pfam_Sushi_SCR_CCP,superfamily_Sushi_SCR_CCP,smart_Sushi_SCR_CCP,pfscan_Sushi_SCR_CCP	-	no_errors	CFH	HGNC	ENSG00000000971	tier1	-	-	64	0	0.00	57	6	9.52	60	0	0.00	103	11	9.65
C8A	0	genome.wustl.edu	37	1	57378074	57378074	+	Splice_Site	SNP	A	A	G			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	1	57378074	57378074	A	G	SNP	C8A	ENST00000361249	human	ensembl	74_37	+1	known	splice_site	c.1381-2	e10-2	0.910	-	-	-	no_errors	C8A	HGNC	ENSG00000157131	tier1	-	-	53	0	0.00	50	12	19.35	38	0	0.00	63	7	9.72
CDK12	0	genome.wustl.edu	37	17	37628001	37628001	+	Missense_Mutation	SNP	A	A	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	17	37628001	37628001	A	T	SNP	CDK12	ENST00000447079	human	ensembl	74_37	+1	known	missense	c.1916	p.D639V	1.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	CDK12	HGNC	ENSG00000167258	tier1	-	-	72	0	0.00	36	8	18.18	149	0	0.00	192	21	9.86
SLC25A3	0	genome.wustl.edu	37	12	98989563	98989563	+	Silent	SNP	C	C	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	12	98989563	98989563	C	A	SNP	SLC25A3	ENST00000188376	human	ensembl	74_37	+1	known	silent	c.216	p.V72	1.000	pfam_Mitochondrial_sb/sol_carrier,superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier	pfam_Mitochondrial_sb/sol_carrier,superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier	-	no_errors	SLC25A3	HGNC	ENSG00000075415	tier1	rs1063501	-	72	0	0.00	42	6	12.50	123	0	0.00	142	12	7.79
AR	0	genome.wustl.edu	37	X	66765161	66765161	+	Missense_Mutation	SNP	A	A	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	X	66765161	66765161	A	T	SNP	AR	ENST00000374690	human	ensembl	74_37	+1	known	missense	c.173	p.Q58L	0.920	pfam_Andrgn_rcpt	pfam_Andrgn_rcpt,pfam_Znf_hrmn_rcpt,pfam_Nucl_hrmn_rcpt_lig-bd_core,superfamily_Nucl_hormone_rcpt_ligand-bd,smart_Znf_hrmn_rcpt,smart_Nucl_hrmn_rcpt_lig-bd_core,pfscan_Znf_hrmn_rcpt,prints_Andrgn_rcpt,prints_Znf_hrmn_rcpt	-	no_errors	AR	HGNC	ENSG00000169083	tier1	rs200185441	-	68	0	0.00	43	4	8.51	0	0	0.00	1	0	0.00
CTBP1	0	genome.wustl.edu	37	4	1231728	1231728	+	Silent	SNP	G	G	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	4	1231728	1231728	G	A	SNP	CTBP1	ENST00000510568	human	ensembl	74_37	-1	putative	silent	c.405	p.A135	0.001	NULL	NULL	-	no_errors	CTBP1	HGNC	ENSG00000159692	tier1	-	-	106	1	0.93	66	16	19.28	0	0	0.00	0	0	0.00
SLC25A3	0	genome.wustl.edu	37	12	98987855	98987855	+	Silent	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	12	98987855	98987855	C	T	SNP	SLC25A3	ENST00000228318	human	ensembl	74_37	+1	known	silent	c.99	p.S33	0.002	NULL	pfam_Mitochondrial_sb/sol_carrier,superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier	-	no_errors	SLC25A3	HGNC	ENSG00000075415	tier1	-	-	100	0	0.00	40	8	16.67	2	0	0.00	1	1	50.00
ZNF43	0	genome.wustl.edu	37	19	22002025	22002026	+	Splice_Site	INS	-	-	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	19	22002025	22002026	-	A	INS	ZNF43	ENST00000354959	human	ensembl	74_37	-1	known	splice_site_ins	c.4-3_4-2	e2-2	0.896:0.834	-	-	-	no_errors	ZNF43	HGNC	ENSG00000198521	tier1			70	0	0.00	30	3	9.09	1	0	0.00	1	0	0.00
RGMA	0	genome.wustl.edu	37	15	93588269	93588269	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	15	93588269	93588269	C	T	SNP	RGMA	ENST00000329082	human	ensembl	74_37	-1	known	missense	c.1312	p.A438T	0.000	NULL	pfam_RGM_N,pfam_RGM_C	-	no_errors	RGMA	HGNC	ENSG00000182175	tier1	-	-	24	0	0.00	12	6	33.33	4	0	0.00	4	7	58.33
SELPLG	0	genome.wustl.edu	37	12	109017341	109017341	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A6RU-01A-11D-A32I-09	TCGA-K1-A6RU-10A-01D-A32I-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	4e02a96d-ef23-4b00-8641-d581b76ddd9b	03aec406-2c3f-495c-9c57-e8a624ff3317	12	109017341	109017341	G	A	SNP	SELPLG	ENST00000550948	human	ensembl	74_37	-1	known	missense	c.743	p.A248V	0.000	NULL	NULL	-	no_errors	SELPLG	HGNC	ENSG00000110876	tier1	-	-	97	0	0.00	73	14	16.09	47	0	0.00	55	3	5.17