Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
LGMN	0	genome.wustl.edu	37	14	93182482	93182482	+	Missense_Mutation	SNP	T	T	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	14	93182482	93182482	T	A	SNP	LGMN	ENST00000334869	human	ensembl	74_37	-1	known	missense	c.403	p.S135C	1.000	pfam_Peptidase_C13,prints_Peptidase_C13	pfam_Peptidase_C13,prints_Peptidase_C13	-	no_errors	LGMN	HGNC	ENSG00000100600	tier1	-	-	53	0	0.00	75	11	12.79						
FCHO1	0	genome.wustl.edu	37	19	17886830	17886830	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	19	17886830	17886830	G	A	SNP	FCHO1	ENST00000252771	human	ensembl	74_37	+1	known	missense	c.1042	p.D348N	0.994	NULL	pfam_Muniscin_C-term_mu_dom,pfam_FCH_dom,superfamily_Clathrin_mu_C,smart_FCH_dom,pfscan_FCH_dom	-	no_errors	FCHO1	HGNC	ENSG00000130475	tier1	-	-	62	0	0.00	91	13	12.50						
TLL1	0	genome.wustl.edu	37	4	166915615	166915615	+	Silent	SNP	C	C	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	4	166915615	166915615	C	A	SNP	TLL1	ENST00000061240	human	ensembl	74_37	+1	known	silent	c.444	p.A148	0.976	pirsf_BMP_1/tolloid-like	pfam_CUB_dom,pfam_Peptidase_M12A,pfam_EGF-like_Ca-bd_dom,superfamily_CUB_dom,smart_Peptidase_Metallo,smart_CUB_dom,smart_EGF-like_Ca-bd_dom,smart_EG-like_dom,pirsf_BMP_1/tolloid-like,pfscan_CUB_dom,pfscan_EG-like_dom,prints_Peptidase_M12A	-	no_errors	TLL1	HGNC	ENSG00000038295	tier1	-	-	43	0	0.00	8	4	33.33						
KIAA0040	0	genome.wustl.edu	37	1	175129948	175129955	+	Frame_Shift_Del	DEL	TCTTCTTG	TCTTCTTG	-			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	TCTTCTTG	TCTTCTTG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	1	175129948	175129955	TCTTCTTG	-	DEL	KIAA0040	ENST00000423313	human	ensembl	74_37	-1	known	frame_shift_del	c.202_195	p.N65fs	0.979:0.335:0.011:0.006:0.005:0.014:0.019:0.212	NULL	NULL	-	no_errors	KIAA0040	HGNC	ENSG00000235750	tier1														
NKX6-3	0	genome.wustl.edu	37	8	41505619	41505619	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	8	41505619	41505619	G	A	SNP	NKX6-3	ENST00000518699	human	ensembl	74_37	-1	known	missense	c.518	p.A173V	1.000	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom,prints_HTH_motif	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom,prints_HTH_motif,prints_Homeobox_metazoa	-	no_errors	NKX6-3	HGNC	ENSG00000165066	tier1	-	-	61	0	0.00	117	20	14.49						
BRINP1	0	genome.wustl.edu	37	9	121971060	121971060	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	9	121971060	121971060	C	T	SNP	BRINP1	ENST00000265922	human	ensembl	74_37	-1	known	missense	c.1082	p.R361H	1.000	NULL	pfam_MACPF,smart_MACPF	-	no_errors	BRINP1	HGNC	ENSG00000078725	tier1	-	-	108	0	0.00	118	57	32.57						
STAB2	0	genome.wustl.edu	37	12	104156110	104156110	+	Missense_Mutation	SNP	G	G	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	12	104156110	104156110	G	C	SNP	STAB2	ENST00000388887	human	ensembl	74_37	+1	known	missense	c.7418	p.G2473A	0.724	NULL	pfam_FAS1_domain,pfam_Link,superfamily_C-type_lectin_fold,superfamily_FAS1_domain,superfamily_Growth_fac_rcpt_N_dom,smart_EG-like_dom,smart_EGF_laminin,smart_EGF-like_Ca-bd_dom,smart_FAS1_domain,smart_Link,pfscan_EG-like_dom,pfscan_FAS1_domain,pfscan_Link	-	no_errors	STAB2	HGNC	ENSG00000136011	tier1	-	-	51	0	0.00	67	12	15.19						
MMP27	0	genome.wustl.edu	37	11	102575384	102575384	+	Silent	SNP	A	A	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	11	102575384	102575384	A	G	SNP	MMP27	ENST00000260229	human	ensembl	74_37	-1	known	silent	c.225	p.T75	0.987	pfam_Peptidoglycan-bd-like,superfamily_Peptidoglycan-bd-like,pirsf_Pept_M10A_Metazoans	pfam_Pept_M10_metallopeptidase,pfam_Hemopexin-like_repeat,pfam_Peptidoglycan-bd-like,superfamily_Hemopexin-like_dom,superfamily_Peptidoglycan-bd-like,smart_Peptidase_Metallo,smart_Hemopexin-like_repeat,pirsf_Pept_M10A_Metazoans,prints_Pept_M10A	-	no_errors	MMP27	HGNC	ENSG00000137675	tier1	-	-	69	0	0.00	51	9	15.00						
TGFBRAP1	0	genome.wustl.edu	37	2	105883847	105883847	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	2	105883847	105883847	C	T	SNP	TGFBRAP1	ENST00000258449	human	ensembl	74_37	-1	known	missense	c.2576	p.R859Q	1.000	NULL	pfam_VPS39/TGF_beta_rcpt-assoc_2,pfam_VPS39/TGF_beta_rcpt-assoc_1,pfam_Clathrin_H-chain/VPS_repeat,pfam_Citron	-	no_errors	TGFBRAP1	HGNC	ENSG00000135966	tier1	-	-	32	0	0.00	43	11	20.37						
ENSG00000270726	0	genome.wustl.edu	37	X	155252089	155252089	+	R	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	X	155252089	155252089	C	T	SNP	ENSG00000270726	ENST00000285718	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	AJ271736.10	Clone_based_vega_gene	ENSG00000270726	tier1	-	-	70	0	0.00	102	41	28.67						
TMEM217	0	genome.wustl.edu	37	6	37182996	37182996	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	37182996	37182996	C	T	SNP	TMEM217	ENST00000336655	human	ensembl	74_37	-1	known	missense	c.668	p.R223K	0.000	NULL	NULL	-	no_errors	TMEM217	HGNC	ENSG00000172738	tier1	-	-	74	0	0.00	36	469	92.87						
SSX2IP	0	genome.wustl.edu	37	1	85113279	85113279	+	Missense_Mutation	SNP	A	A	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	1	85113279	85113279	A	G	SNP	SSX2IP	ENST00000342203	human	ensembl	74_37	-1	known	missense	c.1682	p.V561A	0.000	NULL	pfam_Afadin/alpha-actinin-bd	-	no_errors	SSX2IP	HGNC	ENSG00000117155	tier1	-	-	50	0	0.00	21	30	58.82						
LONRF3	0	genome.wustl.edu	37	X	118124513	118124513	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	X	118124513	118124513	C	G	SNP	LONRF3	ENST00000371628	human	ensembl	74_37	+1	known	missense	c.1405	p.L469V	0.215	pfam_Znf_C3HC4_RING-type,smart_Znf_RING,pfscan_Znf_RING	pfam_Pept_S16_N,pfam_Znf_C3HC4_RING-type,superfamily_PUA-like_domain,smart_TPR_repeat,smart_Znf_RING,smart_Pept_S16_N,pfscan_TPR_repeat,pfscan_TPR-contain_dom,pfscan_Znf_RING	-	no_errors	LONRF3	HGNC	ENSG00000175556	tier1	-	-	26	0	0.00	11	11	50.00						
PTK2	0	genome.wustl.edu	37	8	141900797	141900797	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	8	141900797	141900797	G	T	SNP	PTK2	ENST00000395218	human	ensembl	74_37	-1	known	missense	c.40	p.P14T	0.539	NULL	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Focal_adhesion_kin_target_dom,pfam_Prot_kinase_dom,pfam_FERM_central,superfamily_Kinase-like_dom,superfamily_Focal_adhesion_kin_target_dom,superfamily_FERM_central,smart_Band_41_domain,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_FERM_domain,pfscan_Prot_kinase_dom,prints_Ser-Thr/Tyr_kinase_cat_dom	-	no_errors	PTK2	HGNC	ENSG00000169398	tier1	-	-	95	0	0.00	87	21	19.44						
NUTM1	0	genome.wustl.edu	37	15	34649175	34649175	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	15	34649175	34649175	C	G	SNP	NUTM1	ENST00000333756	human	ensembl	74_37	+1	known	missense	c.2882	p.P961R	0.002	NULL	NULL	-	no_errors	NUTM1	HGNC	ENSG00000184507	tier1	-	-	32	0	0.00	39	8	17.02						
HBD	0	genome.wustl.edu	37	11	5255646	5255646	+	Silent	SNP	A	A	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	11	5255646	5255646	A	C	SNP	HBD	ENST00000380299	human	ensembl	74_37	-1	known	silent	c.18	p.P6	0.000	superfamily_Globin-like,pfscan_Globin	pfam_Globin,superfamily_Globin-like,prints_Haemoglobin_b,pfscan_Globin	-	no_errors	HBD	HGNC	ENSG00000223609	tier1	-	-	108	0	0.00	117	11	8.59						
ACAN	0	genome.wustl.edu	37	15	89398733	89398733	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	15	89398733	89398733	C	T	SNP	ACAN	ENST00000439576	human	ensembl	74_37	+1	known	missense	c.2917	p.L973F	0.000	NULL	pfam_Link,pfam_C-type_lectin,pfam_Ig_V-set,pfam_Sushi_SCR_CCP,pfam_EG-like_dom,superfamily_C-type_lectin_fold,superfamily_Sushi_SCR_CCP,smart_Ig_sub,smart_Ig_V-set_subgr,smart_Link,smart_EG-like_dom,smart_C-type_lectin,smart_Sushi_SCR_CCP,pfscan_EG-like_dom,pfscan_C-type_lectin,pfscan_Link,pfscan_Sushi_SCR_CCP,pfscan_Ig-like_dom,prints_Link	-	no_errors	ACAN	HGNC	ENSG00000157766	tier1	-	-	71	0	0.00	69	12	14.81						
PLCE1	0	genome.wustl.edu	37	10	96012079	96012079	+	Nonsense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	10	96012079	96012079	G	T	SNP	PLCE1	ENST00000260766	human	ensembl	74_37	+1	known	nonsense	c.3103	p.G1035*	1.000	NULL	pfam_PLipase_C_PInositol-sp_X_dom,pfam_PLipase_C_Pinositol-sp_Y,pfam_Ras-assoc,pfam_RasGRF_CDC25,pfam_PLipase_C_EF-hand-like,pfam_C2_dom,superfamily_PLC-like_Pdiesterase_TIM-brl,superfamily_Ras_GEF_dom,superfamily_C2_dom,smart_RasGRF_CDC25,smart_PLipase_C_PInositol-sp_X_dom,smart_PLipase_C_Pinositol-sp_Y,smart_C2_dom,smart_Ras-assoc,pfscan_C2_dom,pfscan_Ras-assoc,pfscan_PLipase_C_PInositol-sp_X_dom,pfscan_PLipase_C_Pinositol-sp_Y,pfscan_RasGRF_CDC25,prints_Pinositol_PLipase_C	-	no_errors	PLCE1	HGNC	ENSG00000138193	tier1	-	-	63	0	0.00	43	7	14.00						
KIAA2026	0	genome.wustl.edu	37	9	5968024	5968024	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	9	5968024	5968024	T	C	SNP	KIAA2026	ENST00000399933	human	ensembl	74_37	-1	novel	missense	c.2207	p.K736R	1.000	NULL	superfamily_Bromodomain	-	no_errors	KIAA2026	HGNC	ENSG00000183354	tier1	-	-	65	0	0.00	30	12	28.57						
LOC101927211	0	genome.wustl.edu	37	6	57015685	57015685	+	R	SNP	G	G	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	57015685	57015685	G	C	SNP	LOC101927211	ENST00000586466	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	RP11-203B9.4	Clone_based_vega_gene	ENSG00000226803	tier1	-	-	35	0	0.00	19	13	40.62						
PTPRU	0	genome.wustl.edu	37	1	29630536	29630536	+	Silent	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	1	29630536	29630536	C	T	SNP	PTPRU	ENST00000345512	human	ensembl	74_37	+1	known	silent	c.2676	p.Y892	0.935	NULL	pfam_Tyr_Pase_rcpt/non-rcpt,pfam_MAM_dom,pfam_Fibronectin_type3,superfamily_ConA-like_lec_gl_sf,superfamily_Fibronectin_type3,smart_MAM_dom,smart_Fibronectin_type3,smart_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_cat,pfscan_Fibronectin_type3,pfscan_MAM_dom,pfscan_Tyr/Dual-sp_Pase,pfscan_Tyr_Pase_rcpt/non-rcpt,prints_Tyr_Pase_rcpt/non-rcpt,prints_MAM_dom	-	no_errors	PTPRU	HGNC	ENSG00000060656	tier1	rs137880682	-	36	0	0.00	52	17	24.64						
RS1	0	genome.wustl.edu	37	X	18660178	18660178	+	Silent	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	X	18660178	18660178	G	A	SNP	RS1	ENST00000379984	human	ensembl	74_37	-1	known	silent	c.621	p.H207	0.995	pfam_Coagulation_fac_5/8-C_type_dom,superfamily_Galactose-bd-like,smart_Coagulation_fac_5/8-C_type_dom,pfscan_Coagulation_fac_5/8-C_type_dom	pfam_Coagulation_fac_5/8-C_type_dom,superfamily_Galactose-bd-like,smart_Coagulation_fac_5/8-C_type_dom,pfscan_Coagulation_fac_5/8-C_type_dom	-	no_errors	RS1	HGNC	ENSG00000102104	tier1	-	-	69	0	0.00	126	39	23.64						
PLCB2	0	genome.wustl.edu	37	15	40591138	40591138	+	Silent	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	15	40591138	40591138	C	T	SNP	PLCB2	ENST00000260402	human	ensembl	74_37	-1	known	silent	c.711	p.T237	0.989	pirsf_PLC-beta,pfam_PLipase_C_EF-hand-like	pirsf_PLC-beta,pfam_PLipase_C_PInositol-sp_X_dom,pfam_PLC-beta_C,pfam_PLipase_C_Pinositol-sp_Y,pfam_PLipase_C_EF-hand-like,pfam_C2_dom,superfamily_PLC-like_Pdiesterase_TIM-brl,superfamily_C2_dom,smart_PLipase_C_PInositol-sp_X_dom,smart_PLipase_C_Pinositol-sp_Y,smart_C2_dom,prints_Pinositol_PLipase_C,pfscan_C2_dom,pfscan_PLipase_C_PInositol-sp_X_dom,pfscan_PLipase_C_Pinositol-sp_Y	-	no_errors	PLCB2	HGNC	ENSG00000137841	tier1	-	-	71	0	0.00	130	16	10.96						
ANKFN1	0	genome.wustl.edu	37	17	54554883	54554883	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	17	54554883	54554883	G	A	SNP	ANKFN1	ENST00000318698	human	ensembl	74_37	+1	known	missense	c.1817	p.R606H	1.000	NULL	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,smart_Fibronectin_type3,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,pfscan_Fibronectin_type3	-	no_errors	ANKFN1	HGNC	ENSG00000153930	tier1	-	-	36	0	0.00	11	14	56.00						
ENSG00000222717	0	genome.wustl.edu	37	5	13174884	13174884	+	R	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	5	13174884	13174884	G	A	SNP	ENSG00000222717	ENST00000410785	human	ensembl	74_37	-1	novel	rna	NULL	NULL	0.001	-	-	-	no_errors	AC016553.1	Clone_based_ensembl_gene	ENSG00000222717	tier1	-	-	66	0	0.00	26	8	23.53						
DOPEY2	0	genome.wustl.edu	37	21	37617593	37617593	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	21	37617593	37617593	C	G	SNP	DOPEY2	ENST00000399151	human	ensembl	74_37	+1	known	missense	c.3315	p.D1105E	0.987	NULL	pfam_Dopey_N	-	no_errors	DOPEY2	HGNC	ENSG00000142197	tier1	-	-	10	0	0.00	33	15	31.25						
SREBF2	0	genome.wustl.edu	37	22	42276779	42276779	+	Missense_Mutation	SNP	A	A	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	22	42276779	42276779	A	G	SNP	SREBF2	ENST00000424354	human	ensembl	74_37	+1	known	missense	c.1921	p.T641A	0.045	NULL	pfam_bHLH_dom,superfamily_bHLH_dom,smart_bHLH_dom,pfscan_bHLH_dom	-	no_errors	SREBF2	HGNC	ENSG00000198911	tier1	-	-	46	0	0.00	56	19	25.33						
ENSG00000205821	0	genome.wustl.edu	37	17	2310396	2310396	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	17	2310396	2310396	G	A	SNP	ENSG00000205821	ENST00000609667	human	ensembl	74_37	-1	known	nonsense	c.376	p.Q126*	0.982	NULL	NULL	-	no_errors	AC006435.1	Clone_based_ensembl_gene	ENSG00000205821	tier1	-	-	49	0	0.00	37	4	9.76						
AMZ1	0	genome.wustl.edu	37	7	2748796	2748796	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	7	2748796	2748796	C	T	SNP	AMZ1	ENST00000312371	human	ensembl	74_37	+1	known	missense	c.689	p.A230V	0.000	NULL	pfam_Pept_M54_archaemetzincn	-	no_errors	AMZ1	HGNC	ENSG00000174945	tier1	-	-	15	0	0.00	17	8	32.00						
ZNF273	0	genome.wustl.edu	37	7	64388928	64388928	+	Frame_Shift_Del	DEL	G	G	-			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	7	64388928	64388928	G	-	DEL	ZNF273	ENST00000476120	human	ensembl	74_37	+1	known	frame_shift_del	c.1222	p.G408fs	1.000	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF273	HGNC	ENSG00000198039	tier1			73	0	0.00	15	2	11.76						
ATG2A	0	genome.wustl.edu	37	11	64678645	64678645	+	Missense_Mutation	SNP	G	G	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	11	64678645	64678645	G	C	SNP	ATG2A	ENST00000421419	human	ensembl	74_37	-1	known	missense	c.1331	p.P444R	0.971	NULL	pfam_Autophagy-rel_C	-	no_errors	ATG2A	HGNC	ENSG00000110046	tier1	-	-	32	0	0.00	34	17	33.33						
NPTN	0	genome.wustl.edu	37	15	73879883	73879883	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	15	73879883	73879883	C	T	SNP	NPTN	ENST00000345330	human	ensembl	74_37	-1	known	missense	c.688	p.A230T	1.000	smart_Ig_sub,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Immunoglobulin,pfam_Ig_V-set,superfamily_MFS_dom_general_subst_transpt,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	NPTN	HGNC	ENSG00000156642	tier1	-	-	42	0	0.00	75	15	16.67						
SLC9A8	0	genome.wustl.edu	37	20	48467301	48467301	+	Frame_Shift_Del	DEL	T	T	-			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	20	48467301	48467301	T	-	DEL	SLC9A8	ENST00000417961	human	ensembl	74_37	+1	known	frame_shift_del	c.537	p.F182fs	0.189	pfam_Cation/H_exchanger,tigrfam_NaH_exchanger	pfam_Cation/H_exchanger,prints_NaH_exchanger,tigrfam_NaH_exchanger	-	no_errors	SLC9A8	HGNC	ENSG00000197818	tier1			14	0	0.00	15	5	25.00						
PKP2	0	genome.wustl.edu	37	12	32975533	32975533	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	12	32975533	32975533	G	T	SNP	PKP2	ENST00000070846	human	ensembl	74_37	-1	known	missense	c.1839	p.N613K	1.000	superfamily_ARM-type_fold,smart_Armadillo	pfam_Armadillo,superfamily_ARM-type_fold,smart_Armadillo,pfscan_Armadillo	-	no_errors	PKP2	HGNC	ENSG00000057294	tier1	-	-	37	0	0.00	53	7	11.67						
CDH18	0	genome.wustl.edu	37	5	19838992	19838992	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	5	19838992	19838992	C	A	SNP	CDH18	ENST00000274170	human	ensembl	74_37	-1	known	missense	c.104	p.R35I	1.000	NULL	pfam_Cadherin,pfam_Cadherin_cytoplasmic-dom,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	CDH18	HGNC	ENSG00000145526	tier1	-	-	143	0	0.00	177	18	9.23						
DCHS2	0	genome.wustl.edu	37	4	155160445	155160445	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	4	155160445	155160445	G	A	SNP	DCHS2	ENST00000357232	human	ensembl	74_37	-1	known	missense	c.6004	p.P2002S	1.000	pfam_Cadherin,superfamily_Cadherin-like,pfscan_Cadherin	pfam_Cadherin,pfam_HTH_CenpB_D-bd_dom,superfamily_Cadherin-like,superfamily_Homeodomain-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	DCHS2	HGNC	ENSG00000197410	tier1	-	-	46	0	0.00	29	8	21.62						
ARHGEF15	0	genome.wustl.edu	37	17	8218893	8218893	+	Splice_Site	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	17	8218893	8218893	G	T	SNP	ARHGEF15	ENST00000361926	human	ensembl	74_37	+1	known	splice_site	c.1421+1	e6+1	1.000	-	-	-	no_errors	ARHGEF15	HGNC	ENSG00000198844	tier1	-	-	34	0	0.00	43	11	20.37						
FOLH1B	0	genome.wustl.edu	37	11	89405054	89405054	+	Splice_Site	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	11	89405054	89405054	G	T	SNP	FOLH1B	ENST00000525540	human	ensembl	74_37	+1	known	splice_site	c.NULL	NULL	1.000	-	-	-	no_errors	FOLH1B	HGNC	ENSG00000134612	tier1	-	-	52	0	0.00	48	5	9.43						
WNK3	0	genome.wustl.edu	37	X	54264792	54264792	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	X	54264792	54264792	G	T	SNP	WNK3	ENST00000354646	human	ensembl	74_37	-1	known	missense	c.3997	p.Q1333K	1.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Kinase_OSR1/WNK_CCT,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	WNK3	HGNC	ENSG00000196632	tier1	-	-	60	0	0.00	91	14	13.33						
HEY2	0	genome.wustl.edu	37	6	126070965	126070965	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	126070965	126070965	G	T	SNP	HEY2	ENST00000368364	human	ensembl	74_37	+1	known	missense	c.43	p.D15Y	1.000	NULL	pfam_bHLH_dom,pfam_Orange,superfamily_bHLH_dom,smart_bHLH_dom,smart_Orange_subgr,pfscan_Orange,pfscan_bHLH_dom,prints_Antifreeze_1	-	no_errors	HEY2	HGNC	ENSG00000135547	tier1	-	-	39	0	0.00	39	4	9.09						
GCM2	0	genome.wustl.edu	37	6	10877424	10877424	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	10877424	10877424	G	A	SNP	GCM2	ENST00000379491	human	ensembl	74_37	-1	known	missense	c.292	p.R98C	0.869	pfam_Tscrpt_reg_GCM_motif,superfamily_Tscrpt_reg_GCM_motif,pfscan_Tscrpt_reg_GCM_motif	pfam_Tscrpt_reg_GCM_motif,superfamily_Tscrpt_reg_GCM_motif,pfscan_Tscrpt_reg_GCM_motif	-	no_errors	GCM2	HGNC	ENSG00000124827	tier1	-	-	36	0	0.00	88	13	12.87						
LOC101927211	0	genome.wustl.edu	37	6	57015498	57015498	+	R	SNP	G	G	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	57015498	57015498	G	C	SNP	LOC101927211	ENST00000589263	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	RP11-203B9.4	Clone_based_vega_gene	ENSG00000226803	tier1	-	-	44	0	0.00	35	10	21.74						
SLC25A48	0	genome.wustl.edu	37	5	135188461	135188461	+	Silent	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	5	135188461	135188461	G	T	SNP	SLC25A48	ENST00000420621	human	ensembl	74_37	+1	known	silent	c.372	p.V124	1.000	pfam_Mitochondrial_sb/sol_carrier,superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier,prints_Mit_carrier	pfam_Mitochondrial_sb/sol_carrier,superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier,prints_Mit_carrier	-	no_errors	SLC25A48	HGNC	ENSG00000145832	tier1	-	-	59	0	0.00	68	20	22.73						
AMZ2	0	genome.wustl.edu	37	17	66247426	66247427	+	R	INS	-	-	CTGTATAG			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	17	66247426	66247427	-	CTGTATAG	INS	AMZ2	ENST00000581779	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.001:0.003	-	-	-	no_errors	AMZ2	HGNC	ENSG00000196704	tier1														
PNMA2	0	genome.wustl.edu	37	8	26366390	26366390	+	R	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	8	26366390	26366390	G	A	SNP	PNMA2	ENST00000518212	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	PNMA2	HGNC	ENSG00000240694	tier1	-	-	34	0	0.00	23	10	30.30						
ENSG00000221136	0	genome.wustl.edu	37	4	176394181	176394181	+	R	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	4	176394181	176394181	C	T	SNP	ENSG00000221136	ENST00000408209	human	ensembl	74_37	+1	novel	rna	NULL	NULL	0.049	-	-	-	no_errors	AC131094.1	Clone_based_ensembl_gene	ENSG00000221136	tier1	-	-	92	0	0.00	62	12	16.22						
ZNF451	0	genome.wustl.edu	37	6	57017071	57017071	+	Silent	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	57017071	57017071	G	A	SNP	ZNF451	ENST00000370706	human	ensembl	74_37	+1	known	silent	c.2805	p.L935	0.997	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF451	HGNC	ENSG00000112200	tier1	-	-	68	0	0.00	90	20	18.18						
FDXACB1	0	genome.wustl.edu	37	11	111746328	111746328	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	11	111746328	111746328	C	T	SNP	FDXACB1	ENST00000260257	human	ensembl	74_37	-1	known	missense	c.1193	p.G398E	0.475	NULL	pfam_DUF2431,pfam_PheS_beta_Fdx_antiC-bd,superfamily_PheS_beta_Fdx_antiC-bd,smart_PheS_beta_Fdx_antiC-bd	-	no_errors	FDXACB1	HGNC	ENSG00000255561	tier1	rs137921139	GMAF=0.0005	15	0	0.00	5	5	50.00						
PIKFYVE	0	genome.wustl.edu	37	2	209215655	209215655	+	Silent	SNP	C	C	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	2	209215655	209215655	C	A	SNP	PIKFYVE	ENST00000264380	human	ensembl	74_37	+1	known	silent	c.5595	p.A1865	0.912	pfam_PInositol-4-P-5-kinase_core,smart_PInositol-4P-5-kinase_core_sub	pfam_PInositol-4-P-5-kinase_core,pfam_Cpn60/TCP-1,pfam_DEP_dom,pfam_Znf_FYVE,superfamily_GroEL-like_apical_dom,superfamily_Znf_FYVE_PHD,smart_Znf_FYVE,smart_DEP_dom,smart_PInositol-4P-5-kinase_core_sub,pfscan_DEP_dom,pfscan_Znf_FYVE-rel	-	no_errors	PIKFYVE	HGNC	ENSG00000115020	tier1	-	-	81	0	0.00	86	14	14.00						
HSPA12B	0	genome.wustl.edu	37	20	3729966	3729966	+	Splice_Site	SNP	G	G	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	20	3729966	3729966	G	C	SNP	HSPA12B	ENST00000254963	human	ensembl	74_37	+1	known	splice_site	c.937+1	e8+1	1.000	-	-	-	no_errors	HSPA12B	HGNC	ENSG00000132622	tier1	-	-	45	0	0.00	72	25	25.77						
CMPK2	0	genome.wustl.edu	37	2	6988912	6988912	+	R	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	2	6988912	6988912	C	T	SNP	CMPK2	ENST00000478738	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	CMPK2	HGNC	ENSG00000134326	tier1	-	-	67	0	0.00	27	13	32.50						
ZNHIT2	0	genome.wustl.edu	37	11	64884288	64884288	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	11	64884288	64884288	G	T	SNP	ZNHIT2	ENST00000310597	human	ensembl	74_37	-1	known	missense	c.838	p.P280T	0.995	NULL	pfam_Znf_HIT,pfscan_Znf_HIT	-	no_errors	ZNHIT2	HGNC	ENSG00000174276	tier1	-	-	18	0	0.00	18	5	21.74						
ALS2CL	0	genome.wustl.edu	37	3	46716064	46716064	+	Missense_Mutation	SNP	A	A	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	3	46716064	46716064	A	T	SNP	ALS2CL	ENST00000318962	human	ensembl	74_37	-1	known	missense	c.2421	p.D807E	0.031	pfscan_VPS9	pfam_MORN,pfam_VPS9,superfamily_DH-domain,smart_MORN,pfscan_VPS9	-	no_errors	ALS2CL	HGNC	ENSG00000178038	tier1	-	-	21	0	0.00	17	25	59.52						
TSKS	0	genome.wustl.edu	37	19	50247562	50247562	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	19	50247562	50247562	C	G	SNP	TSKS	ENST00000246801	human	ensembl	74_37	-1	known	missense	c.1287	p.Q429H	0.974	NULL	NULL	-	no_errors	TSKS	HGNC	ENSG00000126467	tier1	-	-	28	0	0.00	21	19	47.50						
RGS3	0	genome.wustl.edu	37	9	116356457	116356457	+	Silent	SNP	C	C	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	9	116356457	116356457	C	A	SNP	RGS3	ENST00000462403	human	ensembl	74_37	+1	known	silent	c.258	p.T86	0.000	NULL	pfam_RGS_dom,superfamily_Regulat_G_prot_signal_superfam,smart_Regulat_G_prot_signal_superfam,pfscan_Regulat_G_prot_signal_superfam,prints_RGS_dom	-	no_errors	RGS3	HGNC	ENSG00000138835	tier1	-	-	13	0	0.00	18	9	33.33						
TMEM110	0	genome.wustl.edu	37	3	52877150	52877150	+	R	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	3	52877150	52877150	C	T	SNP	TMEM110	ENST00000464769	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.005	-	-	-	no_errors	TMEM110	HGNC	ENSG00000213533	tier1	-	-	13	0	0.00	4	5	55.56						
ENSG00000261616	0	genome.wustl.edu	37	15	99679888	99679888	+	R	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	15	99679888	99679888	C	T	SNP	ENSG00000261616	ENST00000564527	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	RP11-6O2.3	Clone_based_vega_gene	ENSG00000261616	tier1	-	-	47	0	0.00	53	6	10.17						
XRCC3	0	genome.wustl.edu	37	14	104165290	104165290	+	Silent	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	14	104165290	104165290	G	A	SNP	XRCC3	ENST00000352127	human	ensembl	74_37	-1	known	silent	c.886	p.L296	1.000	pfam_D_recomb/repair_Rad51_C,superfamily_P-loop_NTPase,pirsf_D_recomb/repair_RecA-like	pfam_D_recomb/repair_Rad51_C,superfamily_P-loop_NTPase,pirsf_D_recomb/repair_RecA-like,pfscan_D_recomb_RecA/RadB_ATP-bd	-	no_errors	XRCC3	HGNC	ENSG00000126215	tier1	-	-	24	0	0.00	29	10	25.64						
PNMA2	0	genome.wustl.edu	37	8	26366391	26366391	+	R	SNP	A	A	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	8	26366391	26366391	A	T	SNP	PNMA2	ENST00000518212	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	PNMA2	HGNC	ENSG00000240694	tier1	-	-	35	0	0.00	23	11	32.35						
POTEM	0	genome.wustl.edu	37	14	20007611	20007611	+	Silent	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	14	20007611	20007611	G	A	SNP	POTEM	ENST00000547848	human	ensembl	74_37	-1	known	silent	c.1077	p.D359	0.230	superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt	pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,prints_Ankyrin_rpt	-	no_errors	POTEM	HGNC	ENSG00000187537	tier1	-	-	64	0	0.00	23	4	14.81						
IDUA	0	genome.wustl.edu	37	4	995781	995781	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	4	995781	995781	C	A	SNP	IDUA	ENST00000453894	human	ensembl	74_37	+1	known	missense	c.763	p.L255I	1.000	NULL	pfam_Glyco_hydro_39,superfamily_Glycoside_hydrolase_SF,superfamily_Fibronectin_type3,prints_Glyco_hydro_39	-	no_errors	IDUA	HGNC	ENSG00000127415	tier1	-	-	14	0	0.00	19	14	42.42						
CYP4Z1	0	genome.wustl.edu	37	1	47583592	47583592	+	Nonsense_Mutation	SNP	A	A	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	1	47583592	47583592	A	T	SNP	CYP4Z1	ENST00000334194	human	ensembl	74_37	+1	known	nonsense	c.1504	p.K502*	0.507	superfamily_Cyt_P450	pfam_Cyt_P450,superfamily_Cyt_P450,prints_Cyt_P450_E_grp-I,prints_Cyt_P450_E_grp-IV,prints_Cyt_P450,prints_Cyt_P450_E_grp-II	-	no_errors	CYP4Z1	HGNC	ENSG00000186160	tier1	-	-	44	0	0.00	20	12	37.50						
RB1	0	genome.wustl.edu	37	13	48951157	48951157	+	Frame_Shift_Del	DEL	A	A	-			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	13	48951157	48951157	A	-	DEL	RB1	ENST00000267163	human	ensembl	74_37	+1	known	frame_shift_del	c.1319	p.I441fs	1.000	pfam_RB_A,superfamily_Cyclin-like	pfam_RB_C,pfam_RB_A,pfam_RB_B,pfam_RB_N,superfamily_Cyclin-like,smart_Cyclin-like	-	no_errors	RB1	HGNC	ENSG00000139687	tier1			48	0	0.00	11	16	59.26						
IQCK	0	genome.wustl.edu	37	16	19800230	19800230	+	Missense_Mutation	SNP	T	T	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	16	19800230	19800230	T	A	SNP	IQCK	ENST00000320394	human	ensembl	74_37	+1	known	missense	c.676	p.W226R	1.000	NULL	NULL	-	no_errors	IQCK	HGNC	ENSG00000174628	tier1	-	-	62	0	0.00	54	28	34.15						
MT-CO1	0	genome.wustl.edu	37	MT	6264	6264	+	Nonsense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	MT	6264	6264	G	A	SNP	MT-CO1	ENST00000361624	human	ensembl	74_37	+1	known	nonsense	c.361	p.G121*	NULL	pfam_Cyt_c_Oxase_su1,superfamily_Cyt_c_Oxase_su1_dom,pfscan_Cyt_c_Oxase_su1_dom	pfam_Cyt_c_Oxase_su1,superfamily_Cyt_c_Oxase_su1_dom,pfscan_Cyt_c_Oxase_su1_dom,prints_Cyt_c_Oxase_su1	-	no_errors	MT-CO1	HGNC	ENSG00000198804	tier1	-	-	99	0	0.00	24	20	45.45						
DMPK	0	genome.wustl.edu	37	19	46275980	46275980	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	19	46275980	46275980	C	G	SNP	DMPK	ENST00000343373	human	ensembl	74_37	-1	known	missense	c.1293	p.M431I	1.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Myotonic_dystrophy_kinase_coil,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,smart_AGC-kinase_C,pfscan_Prot_kinase_dom	-	no_errors	DMPK	HGNC	ENSG00000104936	tier1	-	-	44	0	0.00	87	22	20.18						
TOPORS-AS1	0	genome.wustl.edu	37	9	32552393	32552393	+	R	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	9	32552393	32552393	G	A	SNP	TOPORS-AS1	ENST00000425533	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	TOPORS-AS1	HGNC	ENSG00000235453	tier1	-	-	33	0	0.00	42	22	33.85						
ZNF462	0	genome.wustl.edu	37	9	109691436	109691436	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	9	109691436	109691436	C	T	SNP	ZNF462	ENST00000457913	human	ensembl	74_37	+1	known	missense	c.5243	p.P1748L	0.994	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF462	HGNC	ENSG00000148143	tier1	-	-	32	0	0.00	39	12	23.53						
ZNF451	0	genome.wustl.edu	37	6	57017129	57017129	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	57017129	57017129	G	A	SNP	ZNF451	ENST00000370706	human	ensembl	74_37	+1	known	missense	c.2863	p.D955N	1.000	NULL	smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF451	HGNC	ENSG00000112200	tier1	-	-	56	0	0.00	72	13	15.29						
IQGAP3	0	genome.wustl.edu	37	1	156507018	156507018	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	1	156507018	156507018	G	A	SNP	IQGAP3	ENST00000361170	human	ensembl	74_37	-1	known	missense	c.3377	p.T1126I	1.000	pfam_RasGAP,superfamily_Rho_GTPase_activation_prot,smart_RasGAP,pfscan_RasGAP	pfam_RasGAP,pfam_RasGAP_C,pfam_IQ_motif_EF-hand-BS,pfam_CH-domain,superfamily_Rho_GTPase_activation_prot,superfamily_CH-domain,superfamily_P-loop_NTPase,superfamily_WW_dom,smart_CH-domain,smart_IQ_motif_EF-hand-BS,smart_RasGAP,pfscan_CH-domain,pfscan_IQ_motif_EF-hand-BS,pfscan_RasGAP	-	no_errors	IQGAP3	HGNC	ENSG00000183856	tier1	-	-	78	0	0.00	105	33	23.91						
OR13D1	0	genome.wustl.edu	37	9	107456942	107456942	+	Silent	SNP	C	C	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	9	107456942	107456942	C	A	SNP	OR13D1	ENST00000318763	human	ensembl	74_37	+1	known	silent	c.240	p.I80	0.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR13D1	HGNC	ENSG00000179055	tier1	-	-	81	0	0.00	84	13	13.40						
APEX2	0	genome.wustl.edu	37	X	55033727	55033727	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	X	55033727	55033727	C	A	SNP	APEX2	ENST00000374987	human	ensembl	74_37	+1	known	missense	c.1416	p.H472Q	0.973	pfam_Znf_GRF	pfam_Endo/exonuclease/phosphatase,pfam_Znf_GRF,superfamily_Endo/exonuclease/phosphatase,tigrfam_AP_endonuc_1	-	no_errors	APEX2	HGNC	ENSG00000169188	tier1	-	-	37	0	0.00	114	24	17.39						
SERPIND1	0	genome.wustl.edu	37	22	21138335	21138335	+	Missense_Mutation	SNP	A	A	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	22	21138335	21138335	A	T	SNP	SERPIND1	ENST00000215727	human	ensembl	74_37	+1	known	missense	c.965	p.K322M	1.000	pfam_Serpin_dom,superfamily_Serpin_dom,smart_Serpin_dom	pfam_Serpin_dom,superfamily_Serpin_dom,smart_Serpin_dom	-	no_errors	SERPIND1	HGNC	ENSG00000099937	tier1	-	-	36	0	0.00	59	13	18.06						
ZSWIM8	0	genome.wustl.edu	37	10	75553404	75553404	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	10	75553404	75553404	G	T	SNP	ZSWIM8	ENST00000398706	human	ensembl	74_37	+1	known	missense	c.2372	p.R791L	1.000	NULL	pfscan_Znf_SWIM	-	no_errors	ZSWIM8	HGNC	ENSG00000214655	tier1	-	-	22	0	0.00	16	18	52.94						
RIT2	0	genome.wustl.edu	37	18	40503652	40503652	+	Missense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	18	40503652	40503652	C	T	SNP	RIT2	ENST00000326695	human	ensembl	74_37	-1	known	missense	c.311	p.R104H	1.000	pfam_Small_GTPase,pfam_MIRO-like,pfam_Small_GTPase_ARF/SAR,pfam_EF_GTP-bd_dom,superfamily_P-loop_NTPase,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Small_GTPase_Rho,smart_Ran_GTPase,tigrfam_Small_GTP-bd_dom	pfam_Small_GTPase,pfam_MIRO-like,pfam_Small_GTPase_ARF/SAR,pfam_EF_GTP-bd_dom,superfamily_P-loop_NTPase,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,smart_Small_GTPase_Rho,smart_Ran_GTPase,prints_Small_GTPase,tigrfam_Small_GTP-bd_dom	-	no_errors	RIT2	HGNC	ENSG00000152214	tier1	-	-	28	0	0.00	20	19	48.72						
ZNF793	0	genome.wustl.edu	37	19	38024339	38024339	+	Missense_Mutation	SNP	A	A	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	19	38024339	38024339	A	G	SNP	ZNF793	ENST00000587986	human	ensembl	74_37	+1	putative	missense	c.272	p.E91G	0.000	NULL	pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,pfscan_Krueppel-associated_box	-	no_errors	ZNF793	HGNC	ENSG00000188227	tier1	-	-	97	0	0.00	46	30	39.47						
MT-ND5	0	genome.wustl.edu	37	MT	12986	12986	+	Missense_Mutation	SNP	T	T	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	MT	12986	12986	T	C	SNP	MT-ND5	ENST00000361567	human	ensembl	74_37	+1	known	missense	c.650	p.L217P	NULL	pfam_DH_UbQ/plastoQ_OxRdtase,tigrfam_DHpl_OxRdtase_5	pfam_DH_UbQ/plastoQ_OxRdtase,pfam_DH_DH_su5_C,pfam_DH_UbQ_OxRdtase_chain5/L_N,tigrfam_DHpl_OxRdtase_5	-	no_errors	MT-ND5	HGNC	ENSG00000198786	tier1	-	-	73	0	0.00	4	52	92.86						
TMEM217	0	genome.wustl.edu	37	6	37186212	37186212	+	Missense_Mutation	SNP	C	C	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	37186212	37186212	C	G	SNP	TMEM217	ENST00000336655	human	ensembl	74_37	-1	known	missense	c.595	p.E199Q	0.013	NULL	NULL	-	no_errors	TMEM217	HGNC	ENSG00000172738	tier1	-	-	19	0	0.00	20	192	90.14						
TP53	0	genome.wustl.edu	37	17	7574017	7574017	+	Missense_Mutation	SNP	C	C	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	17	7574017	7574017	C	A	SNP	TP53	ENST00000269305	human	ensembl	74_37	-1	known	missense	c.1010	p.R337L	0.896	pfam_p53_tetrameristn,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	pfam_p53_D-bd,pfam_p53_tetrameristn,pfam_p53_transactivation_domain,superfamily_p53-like_TF_D-bd,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	-	no_errors	TP53	HGNC	ENSG00000141510	tier1	-	-	20	0	0.00	4	20	83.33						
UBA1	0	genome.wustl.edu	37	X	47060958	47060958	+	Nonsense_Mutation	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	X	47060958	47060958	C	T	SNP	UBA1	ENST00000335972	human	ensembl	74_37	+1	known	nonsense	c.760	p.Q254*	1.000	superfamily_Molybdenum_cofac_synth_MoeB,tigrfam_UBQ-activ_enz_E1	pfam_ThiF_D_FAD-bd,pfam_Ub-activating_enz_e1_C,pfam_UBact_repeat,pfam_Ubiquitin-activating_enzyme,superfamily_Molybdenum_cofac_synth_MoeB,prints_UBQ/SUMO-activ_enz_E1-like,tigrfam_UBQ-activ_enz_E1	-	no_errors	UBA1	HGNC	ENSG00000130985	tier1	-	-	33	0	0.00	68	20	22.73						
RUNDC3B	0	genome.wustl.edu	37	7	87329764	87329764	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	7	87329764	87329764	G	A	SNP	RUNDC3B	ENST00000338056	human	ensembl	74_37	+1	known	missense	c.317	p.S106N	1.000	pfam_Run,pfscan_Run	pfam_Run,smart_Run,pfscan_Run	-	no_errors	RUNDC3B	HGNC	ENSG00000105784	tier1	-	-	28	0	0.00	40	11	21.57						
PLXNB1	0	genome.wustl.edu	37	3	48462755	48462756	+	Frame_Shift_Ins	INS	-	-	GGCCACA			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	3	48462755	48462756	-	GGCCACA	INS	PLXNB1	ENST00000296440	human	ensembl	74_37	-1	known	frame_shift_ins	c.1692_1691	p.G565fs	0.457:0.965	NULL	pfam_Plexin_cytoplasmic_RasGAP_dom,pfam_IPT,pfam_Semap_dom,pfam_Plexin_repeat,superfamily_Semap_dom,superfamily_Rho_GTPase_activation_prot,superfamily_Ig_E-set,superfamily_Plexin-like_fold,smart_Semap_dom,smart_Plexin-like_fold,smart_IPT,pfscan_Semap_dom	-	no_errors	PLXNB1	HGNC	ENSG00000164050	tier1														
ALDH7A1	0	genome.wustl.edu	37	5	125887816	125887816	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	5	125887816	125887816	G	T	SNP	ALDH7A1	ENST00000409134	human	ensembl	74_37	-1	known	missense	c.1214	p.P405H	1.000	pfam_Aldehyde_DH_dom,superfamily_Ald_DH/histidinol_DH	pfam_Aldehyde_DH_dom,superfamily_Ald_DH/histidinol_DH	-	no_errors	ALDH7A1	HGNC	ENSG00000164904	tier1	-	-	34	0	0.00	40	4	9.09						
OR4M2	0	genome.wustl.edu	37	15	22368626	22368626	+	Silent	SNP	A	A	G			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	15	22368626	22368626	A	G	SNP	OR4M2	ENST00000332663	human	ensembl	74_37	+1	putative	silent	c.51	p.L17	0.984	NULL	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR4M2	HGNC	ENSG00000182974	tier1	-	-	138	0	0.00	75	20	21.05						
CASP8AP2	0	genome.wustl.edu	37	6	90584050	90584050	+	R	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	6	90584050	90584050	C	T	SNP	CASP8AP2	ENST00000237177	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.826	-	-	-	no_errors	CASP8AP2	HGNC	ENSG00000118412	tier1	-	-	84	0	0.00	59	7	10.61						
FAM188B	0	genome.wustl.edu	37	7	30921893	30921893	+	Missense_Mutation	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	7	30921893	30921893	G	A	SNP	FAM188B	ENST00000265299	human	ensembl	74_37	+1	known	missense	c.2069	p.R690H	0.004	NULL	NULL	-	no_errors	FAM188B	HGNC	ENSG00000106125	tier1	rs199649103	-	29	0	0.00	71	19	21.11						
PCDHGA3	0	genome.wustl.edu	37	5	140724710	140724710	+	Silent	SNP	C	C	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	5	140724710	140724710	C	T	SNP	PCDHGA3	ENST00000253812	human	ensembl	74_37	+1	known	silent	c.1110	p.D370	0.415	pfam_Cadherin,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin	pfam_Cadherin,pfam_Cadherin_N,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	PCDHGA3	HGNC	ENSG00000254245	tier1	-	-	21	0	0.00	25	9	26.47						
AZI1	0	genome.wustl.edu	37	17	79173312	79173312	+	Missense_Mutation	SNP	G	G	T			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	17	79173312	79173312	G	T	SNP	AZI1	ENST00000269392	human	ensembl	74_37	-1	known	missense	c.1061	p.A354E	0.005	NULL	superfamily_t-SRE	-	no_errors	AZI1	HGNC	ENSG00000141577	tier1	-	-	44	0	0.00	99	9	8.33						
HPCA	0	genome.wustl.edu	37	1	33354493	33354493	+	R	SNP	G	G	A			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	1	33354493	33354493	G	A	SNP	HPCA	ENST00000480118	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	HPCA	HGNC	ENSG00000121905	tier1	-	-	26	0	0.00	46	10	17.86						
BOC	0	genome.wustl.edu	37	3	112969691	112969691	+	Silent	SNP	T	T	C			TCGA-IS-A3KA-01A-11D-A21Q-09	TCGA-IS-A3KA-10A-01D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq 2500	d8f0becd-fda8-41f4-a424-e082f9eae22c	5f7a0fb0-9477-462c-959e-7fc6f0125fec	3	112969691	112969691	T	C	SNP	BOC	ENST00000484034	human	ensembl	74_37	+1	putative	silent	c.387	p.A129	0.000	NULL	pfam_Ig_I-set,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	BOC	HGNC	ENSG00000144857	tier1	-	-	37	0	0.00	67	15	18.29