Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
LILRB5	0	genome.wustl.edu	37	19	54760201	54760201	+	Silent	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	19	54760201	54760201	G	A	SNP	LILRB5	ENST00000449561	human	ensembl	74_37	-1	known	silent	c.360	p.F120	0.000	NULL	smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	LILRB5	HGNC	ENSG00000105609	tier1	-	-	50	0	0.00	45	25	35.71	67	0	0.00	64	44	40.74
SRGAP3	0	genome.wustl.edu	37	3	9055464	9055464	+	Missense_Mutation	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	3	9055464	9055464	C	T	SNP	SRGAP3	ENST00000383836	human	ensembl	74_37	-1	known	missense	c.1876	p.V626M	0.985	pfam_RhoGAP_dom,superfamily_Rho_GTPase_activation_prot,smart_RhoGAP_dom,pfscan_RhoGAP_dom	pfam_RhoGAP_dom,pfam_FCH_dom,pfam_SH3_domain,pfam_SH3_2,superfamily_Rho_GTPase_activation_prot,superfamily_SH3_domain,smart_FCH_dom,smart_RhoGAP_dom,smart_SH3_domain,pfscan_FCH_dom,pfscan_SH3_domain,pfscan_RhoGAP_dom	-	no_errors	SRGAP3	HGNC	ENSG00000196220	tier1	-	-	77	0	0.00	61	32	34.41	98	0	0.00	70	30	30.00
S1PR1	0	genome.wustl.edu	37	1	101704603	101704603	+	Silent	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	101704603	101704603	C	T	SNP	S1PR1	ENST00000305352	human	ensembl	74_37	+1	known	silent	c.63	p.N21	1.000	prints_S1P_rcpt	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_EDG1_rcpt,prints_S1P_rcpt,prints_GPCR_Rhodpsn,prints_Melcrt_ACTH_rcpt	-	no_errors	S1PR1	HGNC	ENSG00000170989	tier1	-	-	39	0	0.00	24	17	41.46	48	0	0.00	44	14	24.14
LINC00910	0	genome.wustl.edu	37	17	41454985	41454985	+	R	SNP	T	T	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	17	41454985	41454985	T	C	SNP	LINC00910	ENST00000587874	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.002	-	-	-	no_errors	LINC00910	HGNC	ENSG00000188825	tier1	-	-	36	0	0.00	48	10	17.24	41	0	0.00	30	4	11.76
TTC40	0	genome.wustl.edu	37	10	134686254	134686254	+	Silent	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	10	134686254	134686254	G	A	SNP	TTC40	ENST00000368582	human	ensembl	74_37	-1	known	silent	c.4437	p.P1479	0.000	NULL	NULL	-	no_errors	TTC40	HGNC	ENSG00000171811	tier1	-	-	38	0	0.00	38	6	13.64	71	0	0.00	53	15	22.06
ENSG00000216073	0	genome.wustl.edu	37	11	97783853	97783853	+	R	SNP	T	T	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	11	97783853	97783853	T	A	SNP	ENSG00000216073	ENST00000401254	human	ensembl	74_37	-1	novel	rna	NULL	NULL	0.071	-	-	-	no_errors	AP003730.1	Clone_based_ensembl_gene	ENSG00000216073	tier1	-	-	27	0	0.00	5	4	44.44	13	0	0.00	14	9	39.13
MYF5	0	genome.wustl.edu	37	12	81111197	81111197	+	Missense_Mutation	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	12	81111197	81111197	C	T	SNP	MYF5	ENST00000228644	human	ensembl	74_37	+1	known	missense	c.355	p.P119S	1.000	pfam_bHLH_dom,superfamily_bHLH_dom,smart_bHLH_dom,pfscan_bHLH_dom	pfam_Basic,pfam_Myf5,pfam_bHLH_dom,superfamily_bHLH_dom,smart_Basic,smart_bHLH_dom,pfscan_bHLH_dom	-	no_errors	MYF5	HGNC	ENSG00000111049	tier1	-	-	38	0	0.00	55	11	16.67	98	0	0.00	83	30	26.32
RYR1	0	genome.wustl.edu	37	19	39075732	39075732	+	Silent	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	19	39075732	39075732	C	T	SNP	RYR1	ENST00000359596	human	ensembl	74_37	+1	known	silent	c.14796	p.I4932	1.000	pfam_Ion_trans_dom	pfam_Ca-rel_channel,pfam_Ryanodine_rcpt,pfam_Ryanrecept_TM4-6,pfam_SPRY_rcpt,pfam_Ins145_P3_rcpt,pfam_MIR_motif,pfam_RIH_assoc-dom,pfam_Ion_trans_dom,superfamily_MIR_motif,superfamily_ConA-like_lec_gl_sf,superfamily_MG_RAP_rcpt_1,smart_MIR_motif,smart_SPla/RYanodine_receptor_subgr,prints_Ryan_recept,pfscan_B30.2/SPRY,pfscan_MIR_motif	-	no_errors	RYR1	HGNC	ENSG00000196218	tier1	-	-	40	0	0.00	92	28	23.33	68	0	0.00	122	38	23.75
KIF2B	0	genome.wustl.edu	37	17	51901724	51901724	+	Missense_Mutation	SNP	T	T	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	17	51901724	51901724	T	C	SNP	KIF2B	ENST00000268919	human	ensembl	74_37	+1	known	missense	c.1330	p.S444P	1.000	pfam_Kinesin_motor_dom,superfamily_P-loop_NTPase,smart_Kinesin_motor_dom,pfscan_Kinesin_motor_dom,prints_Kinesin_motor_dom	pfam_Kinesin_motor_dom,superfamily_P-loop_NTPase,smart_Kinesin_motor_dom,pfscan_Kinesin_motor_dom,prints_Kinesin_motor_dom	-	no_errors	KIF2B	HGNC	ENSG00000141200	tier1	-	-	35	0	0.00	22	12	35.29	58	0	0.00	49	19	27.94
LRP1	0	genome.wustl.edu	37	12	57600488	57600488	+	Silent	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	12	57600488	57600488	C	T	SNP	LRP1	ENST00000243077	human	ensembl	74_37	+1	known	silent	c.11823	p.H3941	1.000	superfamily_Growth_fac_rcpt_N_dom	pfam_LDrepeatLR_classA_rpt,pfam_LDLR_classB_rpt,superfamily_Growth_fac_rcpt_N_dom,superfamily_LDrepeatLR_classA_rpt,smart_LDrepeatLR_classA_rpt,smart_EGF-like_Ca-bd_dom,smart_EG-like_dom,smart_LDLR_classB_rpt,pfscan_EG-like_dom,pfscan_LDrepeatLR_classA_rpt,pfscan_LDLR_classB_rpt,prints_LDrepeatLR_classA_rpt	-	no_errors	LRP1	HGNC	ENSG00000123384	tier1	-	-	41	0	0.00	26	10	27.78	33	0	0.00	20	7	25.93
ABCB6	0	genome.wustl.edu	37	2	220074953	220074953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	220074953	220074953	G	A	SNP	ABCB6	ENST00000265316	human	ensembl	74_37	-1	known	nonsense	c.2419	p.R807*	1.000	superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like	pfam_ABC_transptr_TM_dom,pfam_ABC_transporter-like,superfamily_P-loop_NTPase,superfamily_ABC1_TM_dom,smart_AAA+_ATPase,pfscan_ABC_transporter-like,pfscan_ABC1_TM_dom	-	no_errors	ABCB6	HGNC	ENSG00000115657	tier1	rs201568572	-	63	0	0.00	42	23	35.38	82	0	0.00	50	15	23.08
NID1	0	genome.wustl.edu	37	1	236142371	236142371	+	Silent	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	236142371	236142371	C	T	SNP	NID1	ENST00000264187	human	ensembl	74_37	-1	known	silent	c.3546	p.K1182	0.813	NULL	pfam_G2_nidogen/fibulin_G2F,pfam_LDLR_classB_rpt,pfam_Nidogen_extracell_dom,pfam_Thyroglobulin_1,pfam_EGF-like_Ca-bd_dom,superfamily_GFP,superfamily_Thyroglobulin_1,smart_Nidogen_extracell_dom,smart_EGF-like_Ca-bd_dom,smart_EG-like_dom,smart_G2_nidogen/fibulin_G2F,smart_Thyroglobulin_1,smart_LDLR_classB_rpt,pfscan_EG-like_dom,pfscan_LDLR_classB_rpt,pfscan_G2_nidogen/fibulin_G2F,pfscan_Thyroglobulin_1	-	no_errors	NID1	HGNC	ENSG00000116962	tier1	-	-	37	0	0.00	99	80	44.69	68	1	1.45	197	127	39.20
DBF4	0	genome.wustl.edu	37	7	87514432	87514432	+	Missense_Mutation	SNP	C	C	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	7	87514432	87514432	C	G	SNP	DBF4	ENST00000265728	human	ensembl	74_37	+1	known	missense	c.358	p.H120D	1.000	superfamily_BRCT_dom	pfam_Znf_DBF,superfamily_BRCT_dom,smart_Znf_DBF	-	no_errors	DBF4	HGNC	ENSG00000006634	tier1	-	-	39	0	0.00	30	20	40.00	28	0	0.00	30	11	26.19
LILRB5	0	genome.wustl.edu	37	19	54756803	54756803	+	Missense_Mutation	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	19	54756803	54756803	C	T	SNP	LILRB5	ENST00000450632	human	ensembl	74_37	-1	known	missense	c.1378	p.V460I	0.000	NULL	smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	LILRB5	HGNC	ENSG00000105609	tier1	rs146369950	-	56	0	0.00	66	15	18.52	33	0	0.00	49	7	12.50
C3orf52	0	genome.wustl.edu	37	3	111849257	111849257	+	R	SNP	A	A	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	3	111849257	111849257	A	G	SNP	C3orf52	ENST00000467942	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.014	-	-	-	no_errors	C3orf52	HGNC	ENSG00000114529	tier1	-	-	96	0	0.00	80	26	24.53	103	0	0.00	110	24	17.91
NBEAL1	0	genome.wustl.edu	37	2	203942512	203942512	+	Silent	SNP	T	T	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	203942512	203942512	T	G	SNP	NBEAL1	ENST00000449802	human	ensembl	74_37	+1	known	silent	c.636	p.L212	0.996	superfamily_ARM-type_fold	pfam_BEACH_dom,pfam_WD40_repeat,superfamily_BEACH_dom,superfamily_WD40_repeat_dom,superfamily_ConA-like_lec_gl_sf,superfamily_ARM-type_fold,smart_WD40_repeat,pfscan_BEACH_dom,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	NBEAL1	HGNC	ENSG00000144426	tier1	-	-	78	0	0.00	55	12	17.91	70	0	0.00	76	12	13.64
NOS1	0	genome.wustl.edu	37	12	117710226	117710226	+	Silent	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	12	117710226	117710226	G	A	SNP	NOS1	ENST00000317775	human	ensembl	74_37	-1	known	silent	c.1803	p.R601	0.567	pfam_NO_synthase_oxygenase_dom,superfamily_NO_synthase_oxygenase_dom,pirsf_NOS_euk	pfam_NO_synthase_oxygenase_dom,pfam_FAD-binding_1,pfam_Flavodoxin/NO_synth,pfam_OxRdtase_FAD/D-bd,pfam_PDZ,superfamily_NO_synthase_oxygenase_dom,superfamily_Riboflavin_synthase-like_b-brl,superfamily_PDZ,smart_PDZ,pirsf_NOS_euk,pfscan_PDZ,pfscan_Flavodoxin/NO_synth,prints_Flavoprot_Pyr_Nucl_cyt_Rdtase,prints_Flavdoxin	-	no_errors	NOS1	HGNC	ENSG00000089250	tier1	-	-	55	0	0.00	58	16	21.62	54	0	0.00	20	12	37.50
MUC16	0	genome.wustl.edu	37	19	9048510	9048510	+	Missense_Mutation	SNP	C	C	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	19	9048510	9048510	C	A	SNP	MUC16	ENST00000397910	human	ensembl	74_37	-1	known	missense	c.33121	p.V11041L	0.000	NULL	pfam_SEA_dom,smart_SEA_dom,pfscan_SEA_dom	-	no_errors	MUC16	HGNC	ENSG00000181143	tier1	-	-	101	0	0.00	41	20	32.79	23	0	0.00	20	6	23.08
MROH2B	0	genome.wustl.edu	37	5	40998776	40998776	+	Missense_Mutation	SNP	G	G	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	5	40998776	40998776	G	T	SNP	MROH2B	ENST00000399564	human	ensembl	74_37	-1	known	missense	c.4589	p.A1530D	1.000	superfamily_ARM-type_fold	superfamily_ARM-type_fold	-	no_errors	MROH2B	HGNC	ENSG00000171495	tier1	-	-	33	0	0.00	16	9	36.00	83	0	0.00	65	24	26.97
OR11H12	0	genome.wustl.edu	37	14	19378392	19378392	+	Missense_Mutation	SNP	T	T	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	14	19378392	19378392	T	A	SNP	OR11H12	ENST00000550708	human	ensembl	74_37	+1	known	missense	c.799	p.Y267N	0.538	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR11H12	HGNC	ENSG00000257115	tier1	-	-	35	0	0.00	24	99	80.49	23	0	0.00	17	107	86.29
CYP2C18	0	genome.wustl.edu	37	10	96495187	96495187	+	Missense_Mutation	SNP	T	T	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	10	96495187	96495187	T	G	SNP	CYP2C18	ENST00000285979	human	ensembl	74_37	+1	known	missense	c.1459	p.F487V	0.793	pfam_Cyt_P450,superfamily_Cyt_P450	pfam_Cyt_P450,superfamily_Cyt_P450,prints_Cyt_P450_E_grp-I,prints_Cyt_P450,prints_Cyt_P450_E_grp-IV,prints_Cyt_P450_B	-	no_errors	CYP2C18	HGNC	ENSG00000108242	tier1	-	-	85	0	0.00	64	28	30.43	98	0	0.00	59	32	35.16
TTN	0	genome.wustl.edu	37	2	179438310	179438310	+	Missense_Mutation	SNP	C	C	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	179438310	179438310	C	A	SNP	TTN	ENST00000342992	human	ensembl	74_37	-1	known	missense	c.64845	p.K21615N	1.000	pfam_Fibronectin_type3,superfamily_Calpain_domain_III,superfamily_Fibronectin_type3,superfamily_RNaseH-like_dom,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,pfam_Ig_V-set,pfam_Titin_Z,pfam_PPAK_motif,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,superfamily_Fibronectin_type3,superfamily_Calpain_domain_III,superfamily_RNaseH-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom	-	no_errors	TTN	HGNC	ENSG00000155657	tier1	-	-	41	0	0.00	31	18	36.73	82	1	1.20	54	20	26.67
DIS3L	0	genome.wustl.edu	37	15	66599178	66599178	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	15	66599178	66599178	C	T	SNP	DIS3L	ENST00000319212	human	ensembl	74_37	+1	known	nonsense	c.310	p.R104*	1.000	NULL	NULL	-	no_errors	DIS3L	HGNC	ENSG00000166938	tier1	-	-	54	0	0.00	38	20	34.48	69	0	0.00	38	15	28.30
IL6R	0	genome.wustl.edu	37	1	154401712	154401712	+	Missense_Mutation	SNP	C	C	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	154401712	154401712	C	G	SNP	IL6R	ENST00000368485	human	ensembl	74_37	+1	known	missense	c.126	p.S42R	0.000	smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_IL-6_rcpt_alpha-bd,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	IL6R	HGNC	ENSG00000160712	tier1	-	-	59	0	0.00	100	14	12.28	36	0	0.00	73	15	16.85
KIAA1217	0	genome.wustl.edu	37	10	24810764	24810764	+	Missense_Mutation	SNP	G	G	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	10	24810764	24810764	G	C	SNP	KIAA1217	ENST00000376454	human	ensembl	74_37	+1	known	missense	c.2362	p.E788Q	1.000	NULL	pfam_AIP3_C	-	no_errors	KIAA1217	HGNC	ENSG00000120549	tier1	-	-	32	0	0.00	20	19	48.72	49	0	0.00	19	7	26.92
ARPC3	0	genome.wustl.edu	37	12	110888066	110888066	+	R	SNP	C	C	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	12	110888066	110888066	C	A	SNP	ARPC3	ENST00000471641	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.990	-	-	-	no_errors	ARPC3	HGNC	ENSG00000111229	tier1	-	-	44	0	0.00	43	16	27.12	37	0	0.00	20	6	23.08
CTSL3P	0	genome.wustl.edu	37	9	90388540	90388540	+	R	SNP	C	C	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	9	90388540	90388540	C	G	SNP	CTSL3P	ENST00000354530	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	CTSL3P	HGNC	ENSG00000188029	tier1	rs139706141	-	78	0	0.00	75	25	25.00	64	0	0.00	71	24	25.26
OSBPL6	0	genome.wustl.edu	37	2	179188982	179188982	+	Missense_Mutation	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	179188982	179188982	G	A	SNP	OSBPL6	ENST00000315022	human	ensembl	74_37	+1	known	missense	c.118	p.V40I	0.007	NULL	pfam_Oxysterol-bd,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology	-	no_errors	OSBPL6	HGNC	ENSG00000079156	tier1	-	-	29	0	0.00	39	8	17.02	59	0	0.00	32	27	45.76
LBH	0	genome.wustl.edu	37	2	30454435	30454435	+	R	SNP	A	A	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	30454435	30454435	A	G	SNP	LBH	ENST00000464412	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	LBH	HGNC	ENSG00000213626	tier1	-	-	8	0	0.00	16	7	30.43	19	0	0.00	31	5	13.89
MYO7B	0	genome.wustl.edu	37	2	128350513	128350513	+	Missense_Mutation	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	128350513	128350513	C	T	SNP	MYO7B	ENST00000389524	human	ensembl	74_37	+1	known	missense	c.2137	p.R713W	0.005	pfam_Myosin_head_motor_dom,superfamily_P-loop_NTPase,smart_Myosin_head_motor_dom	pfam_Myosin_head_motor_dom,pfam_MyTH4_dom,pfam_FERM_central,pfam_IQ_motif_EF-hand-BS,pfam_SH3_2,superfamily_P-loop_NTPase,superfamily_FERM_central,superfamily_SH3_domain,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,smart_MyTH4_dom,smart_Band_41_domain,smart_SH3_domain,pfscan_FERM_domain,pfscan_IQ_motif_EF-hand-BS,pfscan_MyTH4_dom,pfscan_SH3_domain,prints_Myosin_head_motor_dom	-	no_errors	MYO7B	HGNC	ENSG00000169994	tier1	-	-	55	0	0.00	53	28	34.57	26	0	0.00	21	7	25.00
UMODL1	0	genome.wustl.edu	37	21	43557666	43557666	+	Missense_Mutation	SNP	T	T	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	21	43557666	43557666	T	A	SNP	UMODL1	ENST00000408989	human	ensembl	74_37	+1	known	missense	c.4277	p.M1426K	0.000	NULL	pfam_ZP_dom,pfam_SEA_dom,pfam_EGF-like_Ca-bd_dom,pfam_EMI_domain,pfam_WAP-type_4-diS_core,superfamily_Fibronectin_type3,superfamily_WAP-type_4-diS_core,smart_WAP-type_4-diS_core,smart_EGF-like_Ca-bd_dom,smart_Fibronectin_type3,smart_ZP_dom,pfscan_EG-like_dom,pfscan_EMI_domain,pfscan_Fibronectin_type3,pfscan_ZP_dom,prints_ZP_dom	-	no_errors	UMODL1	HGNC	ENSG00000177398	tier1	-	-	75	0	0.00	21	19	47.50	61	0	0.00	18	12	40.00
PIK3C2G	0	genome.wustl.edu	37	12	18477970	18477970	+	Missense_Mutation	SNP	C	C	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	12	18477970	18477970	C	A	SNP	PIK3C2G	ENST00000538779	human	ensembl	74_37	+1	known	missense	c.1210	p.Q404K	1.000	NULL	pfam_PI3/4_kinase_cat_dom,pfam_PInositide-3_kin_accessory_dom,pfam_PI3K_C2_dom,pfam_Phox,pfam_PI3K_Ras-bd_dom,pfam_C2_dom,superfamily_Kinase-like_dom,superfamily_ARM-type_fold,superfamily_C2_dom,superfamily_Phox,smart_PI3K_C2_dom,smart_PInositide-3_kin_accessory_dom,smart_PI3/4_kinase_cat_dom,smart_Phox,smart_C2_dom,pfscan_Phox,pfscan_PI3/4_kinase_cat_dom	-	no_errors	PIK3C2G	HGNC	ENSG00000139144	tier1	-	-	44	0	0.00	9	3	25.00	48	0	0.00	46	24	33.33
SLC44A2	0	genome.wustl.edu	37	19	10747106	10747106	+	Missense_Mutation	SNP	C	C	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	19	10747106	10747106	C	G	SNP	SLC44A2	ENST00000335757	human	ensembl	74_37	+1	known	missense	c.1341	p.I447M	1.000	pfam_Choline_transptr-like	pfam_Choline_transptr-like	-	no_errors	SLC44A2	HGNC	ENSG00000129353	tier1	-	-	76	0	0.00	169	18	9.63	31	0	0.00	61	14	18.67
PRDM2	0	genome.wustl.edu	37	1	14107396	14107396	+	Missense_Mutation	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	14107396	14107396	C	T	SNP	PRDM2	ENST00000235372	human	ensembl	74_37	+1	known	missense	c.3106	p.P1036S	0.283	pirsf_RIZ_retinblastoma-bd_prot	pfam_SET_dom,smart_SET_dom,smart_Znf_C2H2-like,pirsf_RIZ_retinblastoma-bd_prot,pfscan_SET_dom,pfscan_Znf_C2H2	-	no_errors	PRDM2	HGNC	ENSG00000116731	tier1	-	-	50	0	0.00	54	20	27.03	35	0	0.00	62	19	23.46
ENSG00000189332	0	genome.wustl.edu	37	11	18231484	18231484	+	Silent	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	11	18231484	18231484	G	A	SNP	ENSG00000189332	ENST00000340135	human	ensembl	74_37	+1	novel	silent	c.270	p.R90	0.998	pfam_Mitochondrial_sb/sol_carrier,superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier	pfam_Mitochondrial_sb/sol_carrier,superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier	-	no_errors	RP11-113D6.10	Clone_based_vega_gene	ENSG00000189332	tier1	-	-	69	0	0.00	60	21	25.93	58	0	0.00	34	22	39.29
HLA-V	0	genome.wustl.edu	37	6	29764977	29764977	+	R	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	6	29764977	29764977	G	A	SNP	HLA-V	ENST00000457107	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	HLA-V	HGNC	ENSG00000181126	tier1	-	-	65	0	0.00	50	26	34.21	100	0	0.00	84	35	29.41
PRDM2	0	genome.wustl.edu	37	1	14107394	14107394	+	Missense_Mutation	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	14107394	14107394	C	T	SNP	PRDM2	ENST00000235372	human	ensembl	74_37	+1	known	missense	c.3104	p.P1035L	0.877	pirsf_RIZ_retinblastoma-bd_prot	pfam_SET_dom,smart_SET_dom,smart_Znf_C2H2-like,pirsf_RIZ_retinblastoma-bd_prot,pfscan_SET_dom,pfscan_Znf_C2H2	-	no_errors	PRDM2	HGNC	ENSG00000116731	tier1	-	-	54	0	0.00	53	20	27.40	34	0	0.00	62	19	23.46
MYO5B	0	genome.wustl.edu	37	18	47500968	47500968	+	Silent	SNP	T	T	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	18	47500968	47500968	T	C	SNP	MYO5B	ENST00000285039	human	ensembl	74_37	-1	known	silent	c.1074	p.L358	0.011	pfam_Myosin_head_motor_dom,superfamily_P-loop_NTPase,smart_Myosin_head_motor_dom	pfam_Myosin_head_motor_dom,pfam_Dil_domain,pfam_IQ_motif_EF-hand-BS,superfamily_P-loop_NTPase,superfamily_Prefoldin,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,pfscan_Dilute,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYO5B	HGNC	ENSG00000167306	tier1	-	-	31	0	0.00	42	16	27.59	50	0	0.00	48	16	25.00
GNS	0	genome.wustl.edu	37	12	65130858	65130858	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	12	65130858	65130858	G	A	SNP	GNS	ENST00000258145	human	ensembl	74_37	-1	known	nonsense	c.1024	p.Q342*	1.000	pfam_Sulfatase,superfamily_Alkaline_phosphatase_core,pirsf_Glcc_6-SO4ase	pfam_Sulfatase,superfamily_Alkaline_phosphatase_core,pirsf_Glcc_6-SO4ase	-	no_errors	GNS	HGNC	ENSG00000135677	tier1	-	-	27	0	0.00	43	299	87.17	89	1	1.11	85	629	88.10
DSCAM	0	genome.wustl.edu	37	21	41719729	41719729	+	Missense_Mutation	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	21	41719729	41719729	C	T	SNP	DSCAM	ENST00000400454	human	ensembl	74_37	-1	known	missense	c.1078	p.V360M	1.000	pfam_Ig_I-set,pfam_Immunoglobulin,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,pfam_Ig_V-set,superfamily_Fibronectin_type3,smart_Ig_sub2,smart_Ig_sub,smart_Ig_V-set_subgr,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	DSCAM	HGNC	ENSG00000171587	tier1	-	-	96	0	0.00	26	19	42.22	89	0	0.00	27	12	30.77
KRT79	0	genome.wustl.edu	37	12	53228026	53228026	+	Missense_Mutation	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	12	53228026	53228026	G	A	SNP	KRT79	ENST00000330553	human	ensembl	74_37	-1	known	missense	c.19	p.R7W	0.397	NULL	pfam_IF,superfamily_STAT_TF_coiled-coil,prints_Keratin_II	-	no_errors	KRT79	HGNC	ENSG00000185640	tier1	-	-	67	0	0.00	70	35	33.33	47	0	0.00	31	12	27.91
FCHO1	0	genome.wustl.edu	37	19	17881328	17881328	+	Missense_Mutation	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	19	17881328	17881328	G	A	SNP	FCHO1	ENST00000252771	human	ensembl	74_37	+1	known	missense	c.431	p.R144H	0.913	NULL	pfam_Muniscin_C-term_mu_dom,pfam_FCH_dom,superfamily_Clathrin_mu_C,smart_FCH_dom,pfscan_FCH_dom	-	no_errors	FCHO1	HGNC	ENSG00000130475	tier1	-	-	35	0	0.00	34	14	29.17	38	0	0.00	16	6	27.27
CPNE6	0	genome.wustl.edu	37	14	24543259	24543259	+	Splice_Site	SNP	G	G	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	14	24543259	24543259	G	T	SNP	CPNE6	ENST00000537691	human	ensembl	74_37	+1	known	splice_site	c.514-1	e5-1	1.000	-	-	-	no_errors	CPNE6	HGNC	ENSG00000100884	tier1	-	-	36	0	0.00	92	9	8.91	105	0	0.00	159	19	10.67
PHLDB2	0	genome.wustl.edu	37	3	111651219	111651219	+	Missense_Mutation	SNP	A	A	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	3	111651219	111651219	A	C	SNP	PHLDB2	ENST00000393925	human	ensembl	74_37	+1	known	missense	c.2105	p.E702A	1.000	NULL	pfam_Pleckstrin_homology,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology	-	no_errors	PHLDB2	HGNC	ENSG00000144824	tier1	-	-	24	0	0.00	22	27	55.10	113	0	0.00	61	48	44.04
NMRK1	0	genome.wustl.edu	37	9	77676433	77676433	+	R	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	9	77676433	77676433	C	T	SNP	NMRK1	ENST00000482537	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.060	-	-	-	no_errors	NMRK1	HGNC	ENSG00000106733	tier1	-	-	40	0	0.00	37	11	22.92	108	0	0.00	145	55	27.50
GBP5	0	genome.wustl.edu	37	1	89732799	89732799	+	Missense_Mutation	SNP	T	T	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	89732799	89732799	T	A	SNP	GBP5	ENST00000343435	human	ensembl	74_37	-1	known	missense	c.466	p.N156Y	0.000	pfam_Guanylate-bd_N,superfamily_P-loop_NTPase	pfam_Guanylate-bd_N,pfam_Guanylate-bd_C,superfamily_Guanylate-bd_C,superfamily_P-loop_NTPase	-	no_errors	GBP5	HGNC	ENSG00000154451	tier1	-	-	39	0	0.00	24	12	33.33	54	0	0.00	60	20	25.00
RAPGEF4	0	genome.wustl.edu	37	2	173679322	173679322	+	R	SNP	T	T	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	173679322	173679322	T	A	SNP	RAPGEF4	ENST00000464976	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	RAPGEF4	HGNC	ENSG00000091428	tier1	-	-	84	0	0.00	52	22	29.73	60	0	0.00	47	24	33.80
WIPI2	0	genome.wustl.edu	37	7	5254196	5254196	+	Missense_Mutation	SNP	G	G	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	7	5254196	5254196	G	C	SNP	WIPI2	ENST00000288828	human	ensembl	74_37	+1	known	missense	c.242	p.R81T	1.000	superfamily_WD40_repeat_dom	pfam_WD40_repeat,superfamily_WD40_repeat_dom,smart_WD40_repeat	-	no_errors	WIPI2	HGNC	ENSG00000157954	tier1	-	-	112	0	0.00	106	20	15.87	45	0	0.00	45	17	27.42
SPEG	0	genome.wustl.edu	37	2	220353597	220353597	+	Silent	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	220353597	220353597	G	A	SNP	SPEG	ENST00000312358	human	ensembl	74_37	+1	novel	silent	c.8124	p.T2708	0.086	superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Ig_I-set,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom	-	no_errors	SPEG	HGNC	ENSG00000072195	tier1	-	-	56	0	0.00	51	20	28.17	14	0	0.00	13	5	27.78
ANO3	0	genome.wustl.edu	37	11	26681890	26681890	+	Missense_Mutation	SNP	G	G	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	11	26681890	26681890	G	C	SNP	ANO3	ENST00000256737	human	ensembl	74_37	+1	known	missense	c.2845	p.E949Q	1.000	pfam_Anoctamin	pfam_Anoctamin	-	no_errors	ANO3	HGNC	ENSG00000134343	tier1	-	-	55	0	0.00	56	22	28.21	83	0	0.00	77	16	17.20
DH6	0	genome.wustl.edu	37	2	84861702	84861702	+	Silent	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	84861702	84861702	C	T	SNP	DH6	ENST00000237449	human	ensembl	74_37	+1	known	silent	c.4590	p.D1530	0.974	superfamily_P-loop_NTPase,smart_AAA+_ATPase	pfam_Dynein_heavy_dom,pfam_Dynein_heavy_dom-2,pfam_ATPase_dyneun-rel_AAA,superfamily_P-loop_NTPase,smart_AAA+_ATPase	-	no_errors	DH6	HGNC	ENSG00000115423	tier1	-	-	63	0	0.00	43	11	20.37	74	0	0.00	71	17	19.32
VPS4B	0	genome.wustl.edu	37	18	61070983	61070983	+	Silent	SNP	T	T	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	18	61070983	61070983	T	C	SNP	VPS4B	ENST00000238497	human	ensembl	74_37	-1	known	silent	c.441	p.K147	1.000	superfamily_P-loop_NTPase	pfam_ATPase_AAA_core,pfam_Vps4_C,pfam_MIT,pfam_IstB_ATP-bd,pfam_ATPase_dyneun-rel_AAA,pfam_D_helicase_Holl-junc_RuvB_N,superfamily_P-loop_NTPase,smart_MIT,smart_AAA+_ATPase	-	no_errors	VPS4B	HGNC	ENSG00000119541	tier1	-	-	58	0	0.00	29	10	25.64	92	0	0.00	81	18	18.18
TTN	0	genome.wustl.edu	37	2	179596646	179596646	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	2	179596646	179596646	G	C	SNP	TTN	ENST00000342992	human	ensembl	74_37	-1	known	nonsense	c.13224	p.Y4408*	0.944	pfam_Ig_I-set,superfamily_RNaseH-like_dom,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,pfam_Ig_V-set,pfam_Titin_Z,pfam_PPAK_motif,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,superfamily_Fibronectin_type3,superfamily_Calpain_domain_III,superfamily_RNaseH-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom	-	no_errors	TTN	HGNC	ENSG00000155657	tier1	-	-	33	0	0.00	19	11	36.67	113	0	0.00	66	48	42.11
UNC13C	0	genome.wustl.edu	37	15	54306133	54306133	+	Missense_Mutation	SNP	A	A	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	15	54306133	54306133	A	G	SNP	UNC13C	ENST00000260323	human	ensembl	74_37	+1	known	missense	c.1033	p.K345E	1.000	NULL	pfam_Munc13_subgr_dom-2,pfam_Ca-dep_secretion_activator,pfam_C2_dom,pfam_Prot_Kinase_C-like_PE/DAG-bd,superfamily_C2_dom,smart_Prot_Kinase_C-like_PE/DAG-bd,smart_C2_dom,pfscan_C2_dom,pfscan_Prot_Kinase_C-like_PE/DAG-bd,prints_C2_dom	-	no_errors	UNC13C	HGNC	ENSG00000137766	tier1	-	-	75	0	0.00	27	14	34.15	65	0	0.00	50	27	35.06
CLDN6	0	genome.wustl.edu	37	16	3065590	3065590	+	Missense_Mutation	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	16	3065590	3065590	G	A	SNP	CLDN6	ENST00000328796	human	ensembl	74_37	-1	known	missense	c.433	p.R145W	0.988	pfam_PMP22/EMP/MP20/Claudin	pfam_PMP22/EMP/MP20/Claudin,prints_Claudin,prints_Claudin6	-	no_errors	CLDN6	HGNC	ENSG00000184697	tier1	-	-	29	0	0.00	30	12	28.57	6	0	0.00	16	2	11.11
RABGGTB	0	genome.wustl.edu	37	1	76259678	76259714	+	R	DEL	CCTAAGAGTGAGACTTAACCCACTTTTAAATTGTTCT	CCTAAGAGTGAGACTTAACCCACTTTTAAATTGTTCT	-			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	CCTAAGAGTGAGACTTAACCCACTTTTAAATTGTTCT	CCTAAGAGTGAGACTTAACCCACTTTTAAATTGTTCT	CCTAAGAGTGAGACTTAACCCACTTTTAAATTGTTCT	-	CCTAAGAGTGAGACTTAACCCACTTTTAAATTGTTCT	CCTAAGAGTGAGACTTAACCCACTTTTAAATTGTTCT	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	76259678	76259714	CCTAAGAGTGAGACTTAACCCACTTTTAAATTGTTCT	-	DEL	RABGGTB	ENST00000459697	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.002:0.001:0.001:0.000:0.002:0.005:0.008:0.009:0.007:0.005:0.003:0.003:0.001:0.001:0.002:0.001:0.001:0.001:0.000:0.000:0.000:0.001:0.001:0.000:0.000:0.000:0.000:0.000:0.001:0.000:0.000:0.000:0.000:0.000:0.001:0.000:0.000	-	-	-	no_errors	RABGGTB	HGNC	ENSG00000137955	tier1			47	0	0.00	30	4	11.76	47	0	0.00	30	4	11.76
SPATA42	0	genome.wustl.edu	37	1	109400924	109400924	+	R	DEL	T	T	-			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	-	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	109400924	109400924	T	-	DEL	SPATA42	ENST00000417241	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	SPATA42	HGNC	ENSG00000203897	tier1			8	0	0.00	15	6	28.57	19	0	0.00	13	6	31.58
LGALS3BP	0	genome.wustl.edu	37	17	76968782	76968783	+	Frame_Shift_Ins	INS	-	-	GTAC			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	-	-	-	GTAC	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	17	76968782	76968783	-	GTAC	INS	LGALS3BP	ENST00000262776	human	ensembl	74_37	-1	known	frame_shift_ins	c.634_633	p.F211fs	0.997:1.000	superfamily_BTB/POZ_fold,pfscan_BTB/POZ-like	pfam_SRCR,pfam_BACK,superfamily_Srcr_rcpt-rel,superfamily_BTB/POZ_fold,smart_Srcr_rcpt-rel,smart_BACK,pfscan_BTB/POZ-like,pfscan_SRCR,prints_SRCR	-	no_errors	LGALS3BP	HGNC	ENSG00000108679	tier1			21	0	0.00	17	8	32.00	60	0	0.00	12	12	50.00
TJP2	0	genome.wustl.edu	37	9	71869131	71869132	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	-	-	-	C	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	9	71869131	71869132	-	C	INS	TJP2	ENST00000539225	human	ensembl	74_37	+1	known	frame_shift_ins	c.3507_3508	p.E1171fs	0.167:0.194	NULL	pfam_PDZ,pfam_GK/Ca_channel_bsu,pfam_SH3_2,superfamily_PDZ,superfamily_P-loop_NTPase,superfamily_SH3_domain,smart_PDZ,smart_GK/Ca_channel_bsu,pfscan_PDZ,pfscan_SH3_domain,pfscan_Guanylate_kin-like,prints_ZonOcculS2,prints_ZonOcculdens	-	no_errors	TJP2	HGNC	ENSG00000119139	tier1			39	0	0.00	46	10	17.86	80	0	0.00	93	15	13.89
TRIM52	0	genome.wustl.edu	37	5	180686884	180686888	+	R	DEL	AAGAG	AAGAG	-			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	AAGAG	AAGAG	AAGAG	-	AAGAG	AAGAG	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	5	180686884	180686888	AAGAG	-	DEL	TRIM52	ENST00000514805	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000:0.000:0.000:0.001:0.002	-	-	-	no_errors	TRIM52	HGNC	ENSG00000183718	tier1			81	0	0.00	38	21	35.59	81	0	0.00	38	21	35.59
101928757	0	genome.wustl.edu	37	10	17891663	17891663	+	Missense_Mutation	SNP	A	A	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	10	17891663	17891663	A	G	SNP	101928757	ENST00000457317	human	ensembl	74_37	+1	known	missense	c.1144	p.K382E	0.970	pfam_C-type_lectin,pfam_Herpes_UL45-like,superfamily_C-type_lectin_fold,smart_C-type_lectin,pfscan_C-type_lectin	pfam_C-type_lectin,pfam_FN_type2_col-bd,pfam_Ricin_B_lectin,pfam_Herpes_UL45-like,superfamily_Ricin_B_lectin,superfamily_C-type_lectin_fold,superfamily_Kringle-like,smart_Ricin_B_lectin,smart_FN_type2_col-bd,smart_C-type_lectin,pfscan_FN_type2_col-bd,pfscan_C-type_lectin,pfscan_Ricin_B_lectin,prints_AntifreezeII	-	no_errors	MRC1L1	Clone_based_vega_gene	ENSG00000183748	tier1	-	-	24	0	0.00	0	9	100.00	16	0	0.00	0	8	100.00
METRN	0	genome.wustl.edu	37	16	766992	766992	+	Missense_Mutation	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	16	766992	766992	G	A	SNP	METRN	ENST00000568223	human	ensembl	74_37	+1	known	missense	c.565	p.V189I	1.000	NULL	NULL	-	no_errors	METRN	HGNC	ENSG00000103260	tier1	-	-	66	0	0.00	111	42	27.45	7	0	0.00	5	3	37.50
CEP350	0	genome.wustl.edu	37	1	179961245	179961245	+	Missense_Mutation	SNP	C	C	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	179961245	179961245	C	G	SNP	CEP350	ENST00000367607	human	ensembl	74_37	+1	known	missense	c.284	p.S95C	0.824	NULL	pfam_CAP-Gly_domain,superfamily_CAP-Gly_domain,pfscan_CAP-Gly_domain	-	no_errors	CEP350	HGNC	ENSG00000135837	tier1	-	-	48	0	0.00	119	14	10.53	95	1	1.04	344	29	7.77
MPO	0	genome.wustl.edu	37	17	56355490	56355490	+	Missense_Mutation	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	17	56355490	56355490	G	A	SNP	MPO	ENST00000340482	human	ensembl	74_37	-1	known	missense	c.998	p.P333L	1.000	pfam_Haem_peroxidase_animal,superfamily_Haem_peroxidase,pfscan_Haem_peroxidase_animal	pfam_Haem_peroxidase_animal,superfamily_Haem_peroxidase,pfscan_Haem_peroxidase_animal,prints_Haem_peroxidase_animal_subgr	-	no_errors	MPO	HGNC	ENSG00000005381	tier1	-	-	21	0	0.00	44	8	15.38	49	0	0.00	85	7	7.61
PRMT5-AS1	0	genome.wustl.edu	37	14	23389819	23389819	+	R	SNP	G	G	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	14	23389819	23389819	G	A	SNP	PRMT5-AS1	ENST00000424245	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	PRMT5-AS1	HGNC	ENSG00000237054	tier1	-	-	28	0	0.00	36	7	16.28	84	0	0.00	117	10	7.87
ARHGEF25	0	genome.wustl.edu	37	12	58008522	58008522	+	Silent	SNP	C	C	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	12	58008522	58008522	C	T	SNP	ARHGEF25	ENST00000333972	human	ensembl	74_37	+1	known	silent	c.984	p.I328	1.000	pfam_DH-domain,superfamily_DH-domain,smart_DH-domain,pfscan_DH-domain	pfam_DH-domain,superfamily_DH-domain,smart_DH-domain,pfscan_Pleckstrin_homology,pfscan_DH-domain	-	no_errors	ARHGEF25	HGNC	ENSG00000240771	tier1	-	-	29	0	0.00	258	24	8.51	38	0	0.00	308	20	6.10
LOC100508046	0	genome.wustl.edu	37	14	20010458	20010458	+	R	SNP	T	T	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	14	20010458	20010458	T	C	SNP	LOC100508046	ENST00000547584	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	RP11-244H18.1	Clone_based_vega_gene	ENSG00000258276	tier1	-	-	21	0	0.00	14	4	22.22	24	1	3.85	35	28	43.08
ENSG00000221281	0	genome.wustl.edu	37	6	67069360	67069361	+	R	INS	-	-	ACACACACAC			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	6	67069360	67069361	-	ACACACACAC	INS	ENSG00000221281	ENST00000408354	human	ensembl	74_37	+1	novel	rna	NULL	NULL	0.000:0.000	-	-	-	no_errors	AC002485.1	Clone_based_ensembl_gene	ENSG00000221281	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
HERC2P4	0	genome.wustl.edu	37	16	32163957	32163957	+	R	SNP	G	G	C			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	16	32163957	32163957	G	C	SNP	HERC2P4	ENST00000563904	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.818	-	-	-	no_errors	HERC2P4	HGNC	ENSG00000230267	tier1	-	-	83	0	0.00	76	20	20.83	3	0	0.00	5	0	0.00
MSH3	0	genome.wustl.edu	37	5	79950712	79950738	+	In_Frame_Del	DEL	GCGGCCGCAGCGGCCGCAGCGCCCCCA	GCGGCCGCAGCGGCCGCAGCGCCCCCA	-			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	GCGGCCGCAGCGGCCGCAGCGCCCCCA	GCGGCCGCAGCGGCCGCAGCGCCCCCA					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	5	79950712	79950738	GCGGCCGCAGCGGCCGCAGCGCCCCCA	-	DEL	MSH3	ENST00000265081	human	ensembl	74_37	+1	known	in_frame_del	c.166_192	p.AAAAAAPPA57in_frame_del	0.238:0.205:0.172:0.140:0.107:0.075:0.032:0.035:0.048:0.057:0.087:0.730:0.747:0.894:0.911:0.915:0.941:0.965:0.997:1.000:1.000:1.000:1.000:0.988:0.984:0.963:0.965	NULL	pfam_D_mismatch_repair_MutS_C,pfam_D_mismatch_repair_MutS_core,pfam_D_mmatch_repair_MutS_con_dom,pfam_D_mismatch_repair_MutS-lik_N,pfam_D_mismatch_repair_MutS_clamp,superfamily_D_mismatch_repair_MutS_core,superfamily_P-loop_NTPase,superfamily_D_mismatch_repair_MutS_N,superfamily_D_mmatch_repair_MutS_con_dom,smart_D_mismatch_repair_MutS_core,smart_D_mismatch_repair_MutS_C	-	no_errors	MSH3	HGNC	ENSG00000113318	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
NBPF10	0	genome.wustl.edu	37	1	145366987	145366987	+	Missense_Mutation	SNP	C	C	G			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	1	145366987	145366987	C	G	SNP	NBPF10	ENST00000342960	human	ensembl	74_37	+1	known	missense	c.10297	p.L3433V	0.000	pfam_NBPF_dom	pfam_NBPF_dom	-	no_errors	NBPF10	HGNC	ENSG00000163386	tier1	-	-	29	0	0.00	10	7	41.18	0	0	0.00	0	0	0.00
WASH3P	0	genome.wustl.edu	37	15	102516467	102516467	+	R	SNP	T	T	A			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	T	T					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	15	102516467	102516467	T	A	SNP	WASH3P	ENST00000557932	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.984	-	-	-	no_errors	WASH3P	HGNC	ENSG00000185596	tier1	-	-	274	1	0.36	282	25	8.14	0	0	0.00	0	0	0.00
PRKCSH	0	genome.wustl.edu	37	19	11558341	11558346	+	In_Frame_Del	DEL	GAGGAG	GAGGAG	-			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	GAGGAG	GAGGAG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	19	11558341	11558346	GAGGAG	-	DEL	PRKCSH	ENST00000252455	human	ensembl	74_37	+1	known	in_frame_del	c.937_942	p.EE316in_frame_del	0.997:0.999:0.994:1.000:1.000:0.720	NULL	pfam_PRKCSH,superfamily_Man6P_isomerase_rcpt-bd_dom,superfamily_LDrepeatLR_classA_rpt,pfscan_EF_hand_dom	-	no_errors	PRKCSH	HGNC	ENSG00000130175	tier1			2	0	0.00	6	5	45.45	2	0	0.00	6	5	45.45
PSD	0	genome.wustl.edu	37	10	104174766	104174766	+	Silent	SNP	G	G	T			TCGA-FX-A2QS-01A-11D-A21Q-09	TCGA-FX-A2QS-11A-11D-A21Q-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	7d332cb1-ba25-47e4-8bf8-d25e14f40d59	5b25b7db-9b62-46da-bb84-314e9186da96	10	104174766	104174766	G	T	SNP	PSD	ENST00000020673	human	ensembl	74_37	-1	known	silent	c.978	p.G326	0.988	NULL	pfam_Sec7_dom,pfam_Pleckstrin_homology,superfamily_Sec7_dom,smart_Sec7_dom,smart_Pleckstrin_homology,pfscan_Pleckstrin_homology,pfscan_Sec7_dom,prints_PH_dom-spectrin-type	-	no_errors	PSD	HGNC	ENSG00000059915	tier1	-	-	71	0	0.00	61	26	29.89	4	0	0.00	4	4	50.00