Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
CEBPE	0	genome.wustl.edu	37	14	23586911	23586911	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	14	23586911	23586911	G	A	SNP	CEBPE	ENST00000206513	human	ensembl	74_37	-1	known	missense	c.631	p.R211W	1.000	pfam_bZIP,smart_bZIP,pirsf_CCAAT/enhancer-binding,pfscan_bZIP	pfam_bZIP,smart_bZIP,pirsf_CCAAT/enhancer-binding,pfscan_bZIP	-	no_errors	CEBPE	HGNC	ENSG00000092067	tier1	-	-	62	0	0.00	61	65	50.39	60	0	0.00	27	20	42.55
SLC22A17	0	genome.wustl.edu	37	14	23818512	23818512	+	Silent	SNP	A	A	G			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	14	23818512	23818512	A	G	SNP	SLC22A17	ENST00000206544	human	ensembl	74_37	-1	known	silent	c.495	p.L165	0.952	pfam_Sub_transporter,pfam_MFS,superfamily_MFS_dom_general_subst_transpt,pfscan_MFS_dom	pfam_Sub_transporter,pfam_MFS,superfamily_MFS_dom_general_subst_transpt,pfscan_MFS_dom	-	no_errors	SLC22A17	HGNC	ENSG00000092096	tier1	-	-	20	0	0.00	15	22	59.46	63	0	0.00	23	16	41.03
TPCN2	0	genome.wustl.edu	37	11	68839473	68839473	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	11	68839473	68839473	G	A	SNP	TPCN2	ENST00000294309	human	ensembl	74_37	+1	known	missense	c.1043	p.G348E	0.000	NULL	pfam_Ion_trans_dom	-	no_errors	TPCN2	HGNC	ENSG00000162341	tier1	-	-	31	0	0.00	28	25	47.17	64	0	0.00	34	29	46.03
OBSCN	0	genome.wustl.edu	37	1	228520994	228520994	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	1	228520994	228520994	C	T	SNP	OBSCN	ENST00000422127	human	ensembl	74_37	+1	known	missense	c.15826	p.R5276C	0.995	pfam_Ig_I-set,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Immunoglobulin,pfam_Ig_V-set,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Fibronectin_type3,pfam_DH-domain,pfam_IQ_motif_EF-hand-BS,superfamily_Kinase-like_dom,superfamily_DH-domain,superfamily_Fibronectin_type3,superfamily_SH3_domain,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,smart_Fibronectin_type3,smart_IQ_motif_EF-hand-BS,smart_DH-domain,smart_Pleckstrin_homology,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_IQ_motif_EF-hand-BS,pfscan_Pleckstrin_homology,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom,pfscan_DH-domain	-	no_errors	OBSCN	HGNC	ENSG00000154358	tier1	-	-	48	0	0.00	52	28	35.00	21	0	0.00	18	13	41.94
KIAA1109	0	genome.wustl.edu	37	4	123175371	123175371	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	4	123175371	123175371	G	A	SNP	KIAA1109	ENST00000264501	human	ensembl	74_37	+1	known	missense	c.5944	p.D1982N	1.000	NULL	pfam_Fragile_site-assoc_C	-	no_errors	KIAA1109	HGNC	ENSG00000138688	tier1	-	-	53	0	0.00	43	7	14.00	55	0	0.00	33	5	13.16
MAP4K5	0	genome.wustl.edu	37	14	50952895	50952895	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	14	50952895	50952895	T	C	SNP	MAP4K5	ENST00000013125	human	ensembl	74_37	-1	known	missense	c.184	p.I62V	1.000	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Citron,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,smart_Citron,pfscan_Prot_kinase_dom	-	no_errors	MAP4K5	HGNC	ENSG00000012983	tier1	-	-	23	0	0.00	32	16	33.33	80	0	0.00	57	32	35.96
DAK	0	genome.wustl.edu	37	11	61113888	61113888	+	Silent	SNP	C	C	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	11	61113888	61113888	C	T	SNP	DAK	ENST00000394900	human	ensembl	74_37	+1	known	silent	c.1641	p.I547	1.000	pfam_DhaL_dom,superfamily_DhaL_dom,tigrfam_DhaK_ATP	pfam_Dak1,pfam_DhaL_dom,superfamily_DhaL_dom,tigrfam_DhaK_ATP	-	no_errors	DAK	HGNC	ENSG00000149476	tier1	-	-	22	0	0.00	23	23	50.00	17	0	0.00	11	6	35.29
WRAP53	0	genome.wustl.edu	37	17	7592319	7592319	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	17	7592319	7592319	C	T	SNP	WRAP53	ENST00000316024	human	ensembl	74_37	+1	known	missense	c.353	p.A118V	0.000	NULL	pfam_WD40_repeat,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	WRAP53	HGNC	ENSG00000141499	tier1	-	-	19	0	0.00	2	48	96.00	88	0	0.00	15	108	85.71
ENSG00000213132	0	genome.wustl.edu	37	3	187896990	187896990	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	3	187896990	187896990	T	C	SNP	ENSG00000213132	ENST00000392468	human	ensembl	74_37	+1	known	missense	c.19	p.F7L	0.010	NULL	NULL	-	no_errors	AC022498.1	Clone_based_ensembl_gene	ENSG00000213132	tier1	-	-	30	0	0.00	24	24	50.00	62	0	0.00	24	21	46.67
DMD	0	genome.wustl.edu	37	X	31515003	31515003	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	X	31515003	31515003	G	A	SNP	DMD	ENST00000357033	human	ensembl	74_37	-1	known	missense	c.8449	p.L2817F	1.000	smart_Spectrin/alpha-actinin,pirsf_Dystrophin/utrophin	pfam_Spectrin_repeat,pfam_EF-hand_dom_typ1,pfam_EF-hand_dom_typ2,pfam_CH-domain,pfam_Znf_ZZ,pfam_WW_dom,pfam_CAMSAP_CH,superfamily_CH-domain,superfamily_WW_dom,smart_CH-domain,smart_Spectrin/alpha-actinin,smart_WW_dom,smart_Znf_ZZ,pirsf_Dystrophin/utrophin,pfscan_CH-domain,pfscan_WW_dom,pfscan_Znf_ZZ	-	no_errors	DMD	HGNC	ENSG00000198947	tier1	-	-	35	0	0.00	32	26	44.83	80	0	0.00	43	32	42.67
PRDM2	0	genome.wustl.edu	37	1	14106018	14106018	+	Silent	SNP	T	T	G			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	1	14106018	14106018	T	G	SNP	PRDM2	ENST00000235372	human	ensembl	74_37	+1	known	silent	c.1728	p.T576	1.000	pirsf_RIZ_retinblastoma-bd_prot	pfam_SET_dom,smart_SET_dom,smart_Znf_C2H2-like,pirsf_RIZ_retinblastoma-bd_prot,pfscan_SET_dom,pfscan_Znf_C2H2	-	no_errors	PRDM2	HGNC	ENSG00000116731	tier1	-	-	25	0	0.00	26	22	45.83	61	0	0.00	52	27	34.18
SCN2A	0	genome.wustl.edu	37	2	166245346	166245346	+	Missense_Mutation	SNP	T	T	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	2	166245346	166245346	T	A	SNP	SCN2A	ENST00000283256	human	ensembl	74_37	+1	known	missense	c.5030	p.F1677Y	1.000	pfam_Ion_trans_dom,pfam_PKD1_2_channel	pfam_Ion_trans_dom,pfam_Na_trans_assoc,pfam_DUF3451,pfam_PKD1_2_channel,smart_IQ_motif_EF-hand-BS,prints_Na_channel_asu,prints_PKD_2,pfscan_IQ_motif_EF-hand-BS	-	no_errors	SCN2A	HGNC	ENSG00000136531	tier1	-	-	83	0	0.00	121	114	48.51	62	0	0.00	60	52	46.43
CFH	0	genome.wustl.edu	37	1	196695646	196695646	+	Silent	SNP	T	T	C			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	1	196695646	196695646	T	C	SNP	CFH	ENST00000367429	human	ensembl	74_37	+1	known	silent	c.1920	p.N640	0.000	pfam_Sushi_SCR_CCP,superfamily_Sushi_SCR_CCP,smart_Sushi_SCR_CCP,pfscan_Sushi_SCR_CCP	pfam_Sushi_SCR_CCP,superfamily_Sushi_SCR_CCP,smart_Sushi_SCR_CCP,pfscan_Sushi_SCR_CCP	-	no_errors	CFH	HGNC	ENSG00000000971	tier1	-	-	34	0	0.00	21	16	43.24	93	0	0.00	53	30	36.14
GPRIN1	0	genome.wustl.edu	37	5	176025351	176025351	+	Silent	SNP	G	G	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	5	176025351	176025351	G	A	SNP	GPRIN1	ENST00000303991	human	ensembl	74_37	-1	known	silent	c.1485	p.G495	0.000	NULL	NULL	-	no_errors	GPRIN1	HGNC	ENSG00000169258	tier1	rs147157849	GMAF=0.0005	26	0	0.00	13	13	48.15	111	0	0.00	64	34	34.34
FAM209A	0	genome.wustl.edu	37	20	55093355	55093355	+	Splice_Site	SNP	T	T	G			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	20	55093355	55093355	T	G	SNP	FAM209A	ENST00000481560	human	ensembl	74_37	+1	known	splice_site	c.NULL	NULL	0.000	-	-	-	no_errors	FAM209A	HGNC	ENSG00000124103	tier1	-	-	15	0	0.00	17	21	55.26	91	0	0.00	42	26	38.24
ARHGEF6	0	genome.wustl.edu	37	X	135827388	135827388	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	X	135827388	135827388	C	A	SNP	ARHGEF6	ENST00000250617	human	ensembl	74_37	-1	known	missense	c.453	p.K151N	0.996	superfamily_SH3_domain	pfam_DH-domain,pfam_SH3_2,pfam_SH3_domain,pfam_CH-domain,pfam_Pleckstrin_homology,pfam_CAMSAP_CH,superfamily_DH-domain,superfamily_CH-domain,superfamily_SH3_domain,smart_CH-domain,smart_SH3_domain,smart_DH-domain,smart_Pleckstrin_homology,pfscan_CH-domain,pfscan_Pleckstrin_homology,pfscan_SH3_domain,pfscan_DH-domain,prints_SH3_domain,prints_SM22_calponin	-	no_errors	ARHGEF6	HGNC	ENSG00000129675	tier1	-	-	26	0	0.00	63	14	18.18	137	0	0.00	96	16	14.29
SNORD109A	0	genome.wustl.edu	37	15	25287085	25287085	+	R	SNP	T	T	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	15	25287085	25287085	T	A	SNP	SNORD109A	ENST00000604135	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.839	-	-	-	no_errors	SNORD109A	HGNC	ENSG00000270246	tier1	-	-	44	0	0.00	78	47	37.60	65	0	0.00	47	35	42.68
GPR137B	0	genome.wustl.edu	37	1	236343299	236343299	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	1	236343299	236343299	G	C	SNP	GPR137B	ENST00000366592	human	ensembl	74_37	+1	known	missense	c.808	p.D270H	1.000	NULL	NULL	-	no_errors	GPR137B	HGNC	ENSG00000077585	tier1	-	-	22	0	0.00	19	17	47.22	63	0	0.00	20	23	53.49
YES1	0	genome.wustl.edu	37	18	736829	736829	+	Missense_Mutation	SNP	T	T	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	18	736829	736829	T	A	SNP	YES1	ENST00000314574	human	ensembl	74_37	-1	known	missense	c.1270	p.N424Y	1.000	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_SH2,pfam_SH3_domain,pfam_SH3_2,superfamily_Kinase-like_dom,superfamily_SH3_domain,smart_SH3_domain,smart_SH2,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_SH2,pfscan_SH3_domain,pfscan_Prot_kinase_dom,prints_Ser-Thr/Tyr_kinase_cat_dom,prints_SH2,prints_SH3_domain	-	no_errors	YES1	HGNC	ENSG00000176105	tier1	-	-	34	0	0.00	26	34	56.67	58	0	0.00	20	18	47.37
WRAP53	0	genome.wustl.edu	37	17	7592045	7592045	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	-	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	17	7592045	7592045	C	-	DEL	WRAP53	ENST00000316024	human	ensembl	74_37	+1	known	frame_shift_del	c.79	p.H28fs	0.345	NULL	pfam_WD40_repeat,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	WRAP53	HGNC	ENSG00000141499	tier1			28	0	0.00	19	267	93.36	84	0	0.00	43	316	88.02
RB1	0	genome.wustl.edu	37	13	48954327	48954328	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	AT	AT	AT	-	AT	AT	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	13	48954327	48954328	AT	-	DEL	RB1	ENST00000267163	human	ensembl	74_37	+1	known	frame_shift_del	c.1448_1449	p.M484fs	1.000:1.000	pfam_RB_A,superfamily_Cyclin-like	pfam_RB_C,pfam_RB_A,pfam_RB_B,pfam_RB_N,superfamily_Cyclin-like,smart_Cyclin-like	-	no_errors	RB1	HGNC	ENSG00000139687	tier1			33	0	0.00	2	25	92.59	42	0	0.00	10	19	65.52
CAMKK2	0	genome.wustl.edu	37	12	121678327	121678328	+	In_Frame_Ins	INS	-	-	TTT			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	-	-	-	TTT	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	12	121678327	121678328	-	TTT	INS	CAMKK2	ENST00000392474	human	ensembl	74_37	-1	known	in_frame_ins	c.1615_1614	p.538in_frame_insK	0.005:0.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	CAMKK2	HGNC	ENSG00000110931	tier1			35	0	0.00	36	7	16.28	13	0	0.00	23	3	11.54
ABCC12	0	genome.wustl.edu	37	16	48149490	48149490	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	16	48149490	48149490	G	T	SNP	ABCC12	ENST00000311303	human	ensembl	74_37	-1	known	missense	c.1825	p.Q609K	1.000	pfam_ABC_transporter-like,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like	pfam_ABC_transptr_TM_dom,pfam_ABC_transporter-like,superfamily_P-loop_NTPase,superfamily_ABC1_TM_dom,smart_AAA+_ATPase,pfscan_ABC_transporter-like,pfscan_ABC1_TM_dom	-	no_errors	ABCC12	HGNC	ENSG00000140798	tier1	-	-	32	0	0.00	27	6	18.18	37	0	0.00	9	6	40.00
DBIL5P	0	genome.wustl.edu	37	17	656793	656793	+	R	SNP	T	T	C			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	17	656793	656793	T	C	SNP	DBIL5P	ENST00000536214	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	DBIL5P	HGNC	ENSG00000231784	tier1	-	-	18	0	0.00	1	23	95.83	100	0	0.00	8	49	84.48
GLB1L2	0	genome.wustl.edu	37	11	134241002	134241002	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	11	134241002	134241002	C	A	SNP	GLB1L2	ENST00000339772	human	ensembl	74_37	+1	known	nonsense	c.1316	p.S439*	0.000	NULL	pfam_Glycoside_Hdrlase_35,pfam_Glyco_hydro_42_N,superfamily_Glycoside_hydrolase_SF,superfamily_Galactose-bd-like,prints_Glycoside_Hdrlase_35	-	no_errors	GLB1L2	HGNC	ENSG00000149328	tier1	-	-	30	0	0.00	2	23	92.00	104	1	0.95	3	41	93.18
PKD1	0	genome.wustl.edu	37	16	2159518	2159520	+	In_Frame_Del	DEL	CCG	CCG	-			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	CCG	CCG	CCG	-	CCG	CCG	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	16	2159518	2159520	CCG	-	DEL	PKD1	ENST00000262304	human	ensembl	74_37	-1	known	in_frame_del	c.5650_5648	p.A1883in_frame_del	1.000:1.000:1.000	superfamily_PKD_dom,smart_PKD/Chitinase_dom,pfscan_PKD_dom,tigrfam_Polycystin_cat	pfam_PKD_dom,pfam_PKD1_2_channel,pfam_PKD/REJ-like,pfam_PLAT/LH2_dom,pfam_C-type_lectin,pfam_WSC_carb-bd,pfam_GPS_dom,superfamily_C-type_lectin_fold,superfamily_Lipase_LipOase,superfamily_PKD_dom,superfamily_Fe_hydrogenase,smart_LRR-contain_N,smart_Leu-rich_rpt_typical-subtyp,smart_Cys-rich_flank_reg_C,smart_WSC_carb-bd_subgr,smart_PKD/Chitinase_dom,smart_C-type_lectin,smart_GPS_dom,smart_PLAT/LH2_dom,prints_PKD_1,pfscan_GPS_dom,pfscan_C-type_lectin,pfscan_PKD_dom,pfscan_PLAT/LH2_dom,pfscan_REJ-like,pfscan_WSC_carb-bd,tigrfam_Polycystin_cat	-	no_errors	PKD1	HGNC	ENSG00000008710	tier1			63	0	0.00	53	28	34.57	16	0	0.00	4	9	69.23
POU3F1	0	genome.wustl.edu	37	1	38511693	38511693	+	Silent	SNP	C	C	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	1	38511693	38511693	C	T	SNP	POU3F1	ENST00000373012	human	ensembl	74_37	-1	known	silent	c.723	p.V241	1.000	pirsf_Transcription_factor_POU	pfam_POU_specific,pfam_Homeobox_dom,superfamily_Lambda_D-bd_dom,superfamily_Homeodomain-like,smart_POU_specific,smart_Homeobox_dom,pirsf_Transcription_factor_POU,pfscan_Homeobox_dom,pfscan_POU_specific,prints_POU	-	no_errors	POU3F1	HGNC	ENSG00000185668	tier1	-	-	30	0	0.00	15	14	48.28	10	0	0.00	7	5	41.67
TIA1	0	genome.wustl.edu	37	2	70441617	70441617	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	-	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	2	70441617	70441617	T	-	DEL	TIA1	ENST00000433529	human	ensembl	74_37	-1	known	frame_shift_del	c.898	p.I300fs	1.000	NULL	pfam_RRM_dom,smart_RRM_dom_euk,smart_RRM_dom,pfscan_RRM_dom	-	no_errors	TIA1	HGNC	ENSG00000116001	tier1			22	0	0.00	10	38	79.17	79	0	0.00	7	34	82.93
ZDBF2	0	genome.wustl.edu	37	2	207173373	207173373	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	2	207173373	207173373	T	C	SNP	ZDBF2	ENST00000374423	human	ensembl	74_37	+1	known	missense	c.4121	p.F1374S	0.022	NULL	pfam_Znf_DBF,smart_Znf_DBF	-	no_errors	ZDBF2	HGNC	ENSG00000204186	tier1	-	-	27	0	0.00	2	50	96.15	118	0	0.00	9	88	90.72
ZNF595	0	genome.wustl.edu	37	4	86907	86907	+	R	SNP	G	G	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	4	86907	86907	G	T	SNP	ZNF595	ENST00000339368	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	ZNF595	HGNC	ENSG00000197701	tier1	-	-	16	0	0.00	3	23	88.46	20	0	0.00	2	14	82.35
EYS	0	genome.wustl.edu	37	6	66045003	66045003	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	6	66045003	66045003	C	G	SNP	EYS	ENST00000370616	human	ensembl	74_37	-1	known	missense	c.1636	p.D546H	0.249	NULL	pfam_Laminin_G,pfam_EG-like_dom,superfamily_ConA-like_lec_gl_sf,smart_EG-like_dom,smart_EGF-like_Ca-bd_dom,smart_Laminin_G,pfscan_EG-like_dom,pfscan_Laminin_G	-	no_errors	EYS	HGNC	ENSG00000188107	tier1	-	-	12	0	0.00	25	10	28.57	62	0	0.00	60	4	6.25
PKHD1L1	0	genome.wustl.edu	37	8	110456116	110456116	+	Silent	SNP	C	C	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	8	110456116	110456116	C	T	SNP	PKHD1L1	ENST00000378402	human	ensembl	74_37	+1	known	silent	c.4776	p.L1592	0.689	pfam_IPT,superfamily_Ig_E-set,smart_IPT	pfam_IPT,pfam_G8_domain,pfam_PA14,superfamily_Ig_E-set,superfamily_Pectin_lyase_fold/virulence,superfamily_Cupredoxin,smart_IPT,smart_PA14,smart_PbH1	-	no_errors	PKHD1L1	HGNC	ENSG00000205038	tier1	-	-	39	0	0.00	21	25	54.35	135	2	1.46	60	55	47.83
AUTS2	0	genome.wustl.edu	37	7	70254924	70254924	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	7	70254924	70254924	G	T	SNP	AUTS2	ENST00000342771	human	ensembl	74_37	+1	known	nonsense	c.2722	p.E908*	0.999	NULL	prints_AUTS2	-	no_errors	AUTS2	HGNC	ENSG00000158321	tier1	-	-	20	0	0.00	23	5	17.86	10	0	0.00	7	0	0.00
OTOG	0	genome.wustl.edu	37	11	17663399	17663399	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	11	17663399	17663399	G	T	SNP	OTOG	ENST00000399391	human	ensembl	74_37	+1	known	missense	c.8232	p.Q2744H	1.000	NULL	pfam_VWF_type-D,pfam_Unchr_dom_Cys-rich,pfam_AbfB,pfam_TIL_dom,superfamily_AbfB,superfamily_TIL_dom,smart_VWF_type-D,smart_Unchr_dom_Cys-rich,smart_VWC_out,smart_Cys_knot_C,pfscan_Cys_knot_C,pfscan_EG-like_dom	-	no_errors	OTOG	HGNC	ENSG00000188162	tier1	-	-	40	0	0.00	26	4	13.33	15	0	0.00	6	0	0.00
CABLES1	0	genome.wustl.edu	37	18	20716015	20716023	+	In_Frame_Del	DEL	GGCGCCGGC	GGCGCCGGC	-			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	GGCGCCGGC	GGCGCCGGC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	18	20716015	20716023	GGCGCCGGC	-	DEL	CABLES1	ENST00000256925	human	ensembl	74_37	+1	known	in_frame_del	c.289_297	p.GGA99in_frame_del	0.983:0.981:0.990:0.998:0.999:0.997:0.999:0.999:0.997	pirsf_Cdk5/c-Abl_linker_Cables	pfam_Cyclin_N,superfamily_Cyclin-like,pirsf_Cdk5/c-Abl_linker_Cables	-	no_errors	CABLES1	HGNC	ENSG00000134508	tier1			0	0	0.00	1	0	0.00	0	0	0.00	1	0	0.00
FAM115C	0	genome.wustl.edu	37	7	143417912	143417912	+	Silent	SNP	C	C	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	7	143417912	143417912	C	T	SNP	FAM115C	ENST00000409703	human	ensembl	74_37	+1	known	silent	c.1137	p.V379	0.092	NULL	NULL	-	no_errors	FAM115C	HGNC	ENSG00000170379	tier1	-	-	59	0	0.00	22	119	84.40	0	0	0.00	0	0	0.00
MUC4	0	genome.wustl.edu	37	3	195513948	195513948	+	Silent	SNP	G	G	A			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	3	195513948	195513948	G	A	SNP	MUC4	ENST00000463781	human	ensembl	74_37	-1	known	silent	c.4503	p.H1501	0.000	NULL	pfam_Nidogen_extracell_dom,pfam_AMOP,pfam_VWF_type-D,smart_Nidogen_extracell_dom,smart_AMOP,smart_VWF_type-D,smart_EG-like_dom,pfscan_AMOP,pfscan_EG-like_dom	-	no_errors	MUC4	HGNC	ENSG00000145113	tier1	-	-	42	0	0.00	29	18	38.30	0	0	0.00	0	0	0.00
NRXN1	0	genome.wustl.edu	37	2	50147836	50147847	+	R	DEL	GTGTGTGTGTGT	GTGTGTGTGTGT	-			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	GTGTGTGTGTGT	GTGTGTGTGTGT					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	2	50147836	50147847	GTGTGTGTGTGT	-	DEL	NRXN1	ENST00000484192	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000:0.001:0.005:0.106:0.113:0.127:0.107:0.109:0.093:0.096:0.025:0.055	-	-	-	no_errors	NRXN1	HGNC	ENSG00000179915	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
GRHPR	0	genome.wustl.edu	37	9	37430971	37430971	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	9	37430971	37430971	G	T	SNP	GRHPR	ENST00000494290	human	ensembl	74_37	+1	known	missense	c.633	p.E211D	0.000	NULL	pfam_D-isomer_2_OHA_DH_D-bd	-	no_errors	GRHPR	HGNC	ENSG00000137106	tier1	-	-	28	0	0.00	46	4	8.00	86	0	0.00	67	2	2.90
ENSG00000234722	0	genome.wustl.edu	37	7	153110008	153110008	+	R	SNP	A	A	G			TCGA-DX-A48L-01A-11D-A307-09	TCGA-DX-A48L-10A-01D-A307-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	f55dccaa-44da-4482-93a8-7853325f5bea	b83395ce-e95f-4de3-a722-0e785b4e2887	7	153110008	153110008	A	G	SNP	ENSG00000234722	ENST00000416982	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.157	-	-	-	no_errors	AC073236.3	Clone_based_vega_gene	ENSG00000234722	tier1	rs112770540	-	41	0	0.00	90	8	8.16	26	0	0.00	35	2	5.41