Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
QSER1	79832	broad.mit.edu	37	11	32997949	32997949	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:32997949G>A	ENST00000399302.2	+	13	5472	c.5137G>A	c.(5137-5139)Gta>Ata	p.V1713I	QSER1_ENST00000527788.1_Missense_Mutation_p.V1474I	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1713										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					TATGAAAAATGTAAAATGGGT	0.318000													5	56					0	0	1	0	0
GLYCTK	132158	broad.mit.edu	37	3	52326966	52326966	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr3:52326966A>T	ENST00000436784.2	+	5	1456	c.1396A>T	c.(1396-1398)Aca>Tca	p.T466S	GLYCTK_ENST00000305690.8_Intron|GLYCTK_ENST00000461183.1_Intron|GLYCTK-AS1_ENST00000493616.1_RNA|GLYCTK_ENST00000477382.1_3'UTR|GLYCTK_ENST00000473032.1_Intron|GLYCTK_ENST00000471180.1_Intron|GLYCTK_ENST00000354773.4_3'UTR			Q8IVS8	GLCTK_HUMAN	glycerate kinase	466					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		GGCCTGGGTCACACCTGAGCT	0.617000													11	22					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141291667	141291667	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:141291667C>T	ENST00000389484.3	-	47	8656	c.7685G>A	c.(7684-7686)cGc>cAc	p.R2562H		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2562	LDL-receptor class A 12.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATGCAGCGGCGATTATAGCA	0.363000										TSP Lung(27;0.18)			14	41					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231112746	231112746	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:231112746G>C	ENST00000392045.3	+	8	972	c.858G>C	c.(856-858)gaG>gaC	p.E286D	SP140_ENST00000343805.6_Missense_Mutation_p.E260D|SP140_ENST00000350136.5_Intron|SP140_ENST00000417495.3_Intron|SP140_ENST00000486687.2_Intron|SP140_ENST00000420434.3_Missense_Mutation_p.E286D	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	286					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AAGACAAGGAGAAGTACCAAG	0.507000													4	29					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41900472	41900472	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr12:41900472C>A	ENST00000298919.7	+	4	666	c.278C>A	c.(277-279)aCc>aAc	p.T93N	PDZRN4_ENST00000402685.2_Missense_Mutation_p.T353N|PDZRN4_ENST00000539469.2_Missense_Mutation_p.T95N			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	353							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				CGTCCACCTACCCCTCCAGTG	0.493000													6	31					0.00198382	0.00217097	1	1	0
GLB1L3	112937	broad.mit.edu	37	11	134151337	134151337	+	Silent	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:134151337G>C	ENST00000389887.5	+	4	2925	c.429G>C	c.(427-429)ctG>ctC	p.L143L	GLB1L3_ENST00000431683.2_Silent_p.L143L			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	143					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		ACCTGGACCTGGAGTATGTGG	0.537000													17	143					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43655005	43655005	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chrX:43655005A>C	ENST00000378069.4	-	7	896	c.749T>G	c.(748-750)cTa>cGa	p.L250R	MAOB_ENST00000538942.1_Missense_Mutation_p.L234R|MAOB_ENST00000536181.1_Missense_Mutation_p.L234R	NM_000898.4	NP_000889.3	P27338	AOFB_HUMAN	monoamine oxidase B	250					xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(2)|skin(5)	21					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	CTCATGGTTTAGGGTCTCCAC	0.418000													16	24					0	0	1	0	0
ATG14	22863	broad.mit.edu	37	14	55848900	55848900	+	Silent	SNP	T	T	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:55848900T>A	ENST00000247178.5	-	6	692	c.657A>T	c.(655-657)gcA>gcT	p.A219A		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	219					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						AAGACACATCTGCGGGGTCTC	0.493000													17	46					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26559644	26559644	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr10:26559644G>A	ENST00000376261.3	+	10	1554	c.1051G>A	c.(1051-1053)Gct>Act	p.A351T	GAD2_ENST00000259271.3_Missense_Mutation_p.A351T	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	351					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	CTTAGCTGTCGCTGACATTTG	0.493000													15	143					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23956757	23956757	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chrX:23956757G>C	ENST00000379211.3	+	8	1428	c.879G>C	c.(877-879)atG>atC	p.M293I		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	293										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						AAGCTCAAATGAAAGTTGAAA	0.348000													22	20					0	0	1	0	0
HSD17B7	51478	broad.mit.edu	37	1	162769603	162769603	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:162769603G>A	ENST00000367917.3	+	5	586	c.518G>A	c.(517-519)aGt>aAt	p.S173N	HSD17B7_ENST00000485405.1_3'UTR|HSD17B7_ENST00000254521.3_Missense_Mutation_p.S173N			P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	173					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity	p.S173N(4)		endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	TCATCTCGCAGTGCAAGGAAA	0.458000													4	54					0	0	1	0	0
HOXD8	3234	broad.mit.edu	37	2	176995668	176995668	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:176995668C>A	ENST00000313173.4	+	1	1201	c.574C>A	c.(574-576)Caa>Aaa	p.Q192K	HOXD8_ENST00000429017.1_Missense_Mutation_p.Q8K|HOXD8_ENST00000548663.1_Missense_Mutation_p.Q88K|HOXD8_ENST00000544999.1_Missense_Mutation_p.Q192K|HOXD-AS2_ENST00000440016.2_RNA|HOXD8_ENST00000450510.2_Missense_Mutation_p.Q192K	NM_001199746.1|NM_019558.3	NP_001186675.1|NP_062458.1	P13378	HXD8_HUMAN	homeobox D8	192					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(5)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		GATGAGACCACAAGGTTGGGA	0.463000													13	41					9.31168e-06	1.13701e-05	1	1	0
MIR329-1	0	broad.mit.edu	37	14	101493161	101493161	+	RNA	SNP	A	A	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:101493161A>T	ENST00000385028.1	+	0	40					NR_029967.1																						TGTTTCTTTAATGAGGACGAA	0.468000													5	216					0	0	1	0	0
EFCC1	79825	broad.mit.edu	37	3	128755841	128755841	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr3:128755841G>C	ENST00000436022.2	+	6	1471	c.160G>C	c.(160-162)Gaa>Caa	p.E54Q	EFCC1_ENST00000480450.1_Missense_Mutation_p.E491Q	NM_024768.2	NP_079044.2			EF-hand and coiled-coil domain containing 1																		GCAGAAGGTGGAAGAGAATGA	0.597000													6	51					0	0	1	0	0
CCT8	10694	broad.mit.edu	37	21	30439889	30439889	+	Silent	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr21:30439889C>G	ENST00000286788.4	-	4	575	c.369G>C	c.(367-369)ctG>ctC	p.L123L	CCT8_ENST00000542732.1_Silent_p.L104L|CCT8_ENST00000540844.1_Silent_p.L50L|CCT8_ENST00000470450.1_5'UTR	NM_006585.2	NP_006576.2	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	123					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|prostate(3)	14						CTGAAACTGACAGGCCAATCC	0.358000													12	35					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82764229	82764229	+	Silent	SNP	A	A	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr7:82764229A>G	ENST00000423517.2	-	3	2974	c.2637T>C	c.(2635-2637)ccT>ccC	p.P879P	PCLO_ENST00000333891.8_Silent_p.P879P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	825	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTCGTGGGCCAGGGGGTGTTG	0.517000													22	204					0	0	1	0	0
TBCE	6905	broad.mit.edu	37	1	235597548	235597548	+	Silent	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:235597548C>T	ENST00000543662.1	+	9	949	c.843C>T	c.(841-843)ggC>ggT	p.G281G	TBCE_ENST00000366601.3_Silent_p.G230G|TBCE_ENST00000472011.1_3'UTR|TBCE_ENST00000406207.1_Silent_p.G230G			Q15813	TBCE_HUMAN	tubulin folding cofactor E	230					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding			NS(1)|endometrium(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	14	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			GGTGCCCAGGCCTGGAGGAAC	0.502000													8	84					0	0	1	0	0
SERTAD4	56256	broad.mit.edu	37	1	210414981	210414981	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:210414981G>C	ENST00000367012.3	+	4	600	c.370G>C	c.(370-372)Gtg>Ctg	p.V124L	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	124	SERTA.						protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		TGATCCTGAAGTGTACCTCCG	0.368000													17	86					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20517346	20517346	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr20:20517346G>T	ENST00000202677.6	-	25	3510	c.3368C>A	c.(3367-3369)tCa>tAa	p.S1123*		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	1123					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						TTCTGGCACTGACTGCAGTAA	0.443000													5	8					0.0293803	0.0298958	1	1	0
TLR2	7097	broad.mit.edu	37	4	154625865	154625865	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr4:154625865C>G	ENST00000260010.6	+	1	3214	c.1806C>G	c.(1804-1806)atC>atG	p.I602M		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	602					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				TCCTGCTGATCCTGCTCACGG	0.582000													4	37					0	0	1	0	0
RGS6	9628	broad.mit.edu	37	14	73029174	73029174	+	Nonstop_Mutation	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:73029174G>C	ENST00000553530.1	+	17	1625	c.1418G>C	c.(1417-1419)tGa>tCa	p.*473S	RGS6_ENST00000554782.1_Intron|RP3-514A23.2_ENST00000555303.1_lincRNA|RGS6_ENST00000555571.1_Nonstop_Mutation_p.*473S|RGS6_ENST00000556437.1_Nonstop_Mutation_p.*491S|RGS6_ENST00000402788.2_Nonstop_Mutation_p.*473S|RGS6_ENST00000343854.6_Nonstop_Mutation_p.*454S|RGS6_ENST00000553525.1_Nonstop_Mutation_p.*491S	NM_001204417.1|NM_001204418.1|NM_001204420.1|NM_001204421.1|NM_001204422.1|NM_004296.5	NP_001191346.1|NP_001191347.1|NP_001191349.1|NP_001191350.1|NP_001191351.1|NP_004287.3	P49758	RGS6_HUMAN	regulator of G-protein signaling 6	0					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		CAGTCCTCCTGACCGTTCCTA	0.667000													6	25					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79175953	79175953	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:79175953G>T	ENST00000554719.1	+	4	987	c.496G>T	c.(496-498)Gat>Tat	p.D166Y	RP11-232C2.2_ENST00000555680.1_RNA|NRXN3_ENST00000335750.5_Missense_Mutation_p.D166Y	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	170	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GAAAGCCAATGATGGGGAATG	0.502000													16	49					0.000566183	0.00065027	1	1	0
H2AFX	3014	broad.mit.edu	37	11	118966003	118966003	+	Silent	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:118966003C>T	ENST00000530167.1	-	1	174	c.102G>A	c.(100-102)ctG>ctA	p.L34L		NM_002105.2	NP_002096.1	P16104	H2AX_HUMAN	H2A histone family, member X	34					DNA damage checkpoint|double-strand break repair via homologous recombination|meiosis|nucleosome assembly|positive regulation of DNA repair|response to ionizing radiation	nucleoplasm|nucleosome	DNA binding|enzyme binding|histone binding			lung(3)	3	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		CCTTCCGCAGCAGCCGGTGTA	0.726000								Chromatin Structure			OREG0021395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	13					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90048805	90048805	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:90048805T>C	ENST00000330947.2	+	5	956	c.596T>C	c.(595-597)aTa>aCa	p.I199T	LRRC8B_ENST00000358200.4_Missense_Mutation_p.I199T|RP5-1007M22.2_ENST00000443562.1_RNA|LRRC8B_ENST00000439853.1_Missense_Mutation_p.I199T	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	199						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		TCAGCTGACATAGATTCCGGC	0.527000													10	41					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186072727	186072727	+	Missense_Mutation	SNP	G	G	T	rs41317483	byFrequency	TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:186072727G>T	ENST00000271588.4	+	69	10926	c.10697G>T	c.(10696-10698)gGc>gTc	p.G3566V	HMCN1_ENST00000367492.2_Missense_Mutation_p.G3566V	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3566	Ig-like C2-type 34.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATGAAAGATGGCCGGCCCCTT	0.433000													3	50					0.004672	0.00501807	1	1	0
NFATC1	4772	broad.mit.edu	37	18	77170782	77170782	+	Silent	SNP	G	G	A	rs146706357		TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr18:77170782G>A	ENST00000253506.5	+	2	876	c.507G>A	c.(505-507)tcG>tcA	p.S169S	NFATC1_ENST00000587635.1_Silent_p.S169S|NFATC1_ENST00000329101.4_Silent_p.S156S|NFATC1_ENST00000591814.1_Silent_p.S169S|NFATC1_ENST00000592223.1_Silent_p.S156S|NFATC1_ENST00000586434.1_Silent_p.S156S|NFATC1_ENST00000542384.1_Silent_p.S169S|NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000318065.5_Silent_p.S156S|NFATC1_ENST00000427363.2_Silent_p.S169S	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	169	Trans-activation domain A (TAD-A).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GAGACCCCTCGTGCCTGAGCC	0.657000													10	32					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23866242	23866242	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:23866242C>T	ENST00000405093.3	-	18	2168	c.2098G>A	c.(2098-2100)Gtg>Atg	p.V700M	MYH6_ENST00000356287.3_Missense_Mutation_p.V700M	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	700	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCCTCCAGCACGCCATTGCAG	0.617000													7	22					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4927385	4927385	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr17:4927385C>T	ENST00000320785.5	+	23	3608	c.3251C>T	c.(3250-3252)cCc>cTc	p.P1084L		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	1084	Pro-rich.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						TACACTACTCCCCCACGAATG	0.652000													12	22					0	0	1	0	0
PLCE1	51196	broad.mit.edu	37	10	95993811	95993811	+	Splice_Site	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr10:95993811G>A	ENST00000260766.3	+	6	2590	c.1955_splice	c.e6-1	p.R652_splice	PLCE1_ENST00000371375.1_Splice_Site_p.R344_splice|PLCE1_ENST00000371385.3_Splice_Site_p.R344_splice|PLCE1_ENST00000371380.2_Splice_Site_p.R652_splice	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	652	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				CTTGCAATAGGTCAAGAAAAG	0.373000													4	20					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692478	20692478	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:20692478G>A	ENST00000315519.2	+	1	688	c.610G>A	c.(610-612)Gca>Aca	p.A204T		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		CCCATTGTTTGCACTGGCCTG	0.488000													14	37					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47693423	47693423	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr21:47693423C>T	ENST00000397708.1	-	8	2329	c.2075G>A	c.(2074-2076)cGg>cAg	p.R692Q	MCM3AP_ENST00000291688.1_Missense_Mutation_p.R692Q			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	692					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					TGGCAAGGGCCGCAGCTCGTG	0.612000													11	32					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161989785	161989785	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:161989785G>A	ENST00000294794.3	-	2	785	c.362C>T	c.(361-363)cCc>cTc	p.P121L	OLFML2B_ENST00000367940.2_Missense_Mutation_p.P121L	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	121										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GGCCGATGGGGGTGCTACACA	0.602000													5	29					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899168	233899168	+	Missense_Mutation	SNP	C	C	T	rs144556397	by1000genomes	TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:233899168C>T	ENST00000233840.3	+	2	544	c.544C>T	c.(544-546)Cgg>Tgg	p.R182W		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	182			R -> Q (in dbSNP:rs2233393).				exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		CTACGCCTACCGGAAACTTCA	0.657000													6	21					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35293132	35293132	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr7:35293132C>A	ENST00000408931.3	-	1	626	c.100G>T	c.(100-102)Gcg>Tcg	p.A34S		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	34						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						TTCTCCGTCGCCTCCTTCTCC	0.647000													4	30					0.00909568	0.0095054	1	1	0
NQO1	1728	broad.mit.edu	37	16	69745151	69745151	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr16:69745151A>T	ENST00000320623.5	-	6	1064	c.553T>A	c.(553-555)Tta>Ata	p.L185I	NQO1_ENST00000379047.3_Missense_Mutation_p.L151I|NQO1_ENST00000561500.1_Missense_Mutation_p.L147I|NQO1_ENST00000564043.1_Missense_Mutation_p.L164I|NQO1_ENST00000379046.2_Missense_Mutation_p.L147I|NQO1_ENST00000439109.2_Missense_Mutation_p.L113I	NM_000903.2	NP_000894.1	P15559	NQO1_HUMAN	NAD(P)H dehydrogenase, quinone 1	185					nitric oxide biosynthetic process|regulation of cellular amino acid metabolic process|response to toxin|synaptic transmission, cholinergic|xenobiotic metabolic process	cytosol	coenzyme binding|cytochrome-b5 reductase activity|electron carrier activity|NAD(P)H dehydrogenase (quinone) activity			autonomic_ganglia(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	10					Dicumarol(DB00266)|Menadione(DB00170)	TGAGGTTCTAAGACTTGGAAG	0.448000													20	167					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112608163	112608163	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr12:112608163G>T	ENST00000550722.1	-	69	11983	c.11588C>A	c.(11587-11589)aCc>aAc	p.T3863N	HECTD4_ENST00000377560.5_Missense_Mutation_p.T3837N|HECTD4_ENST00000430131.2_Missense_Mutation_p.T3587N	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGGGTCCAAGGTGATCTCAGG	0.527000													6	39					8.12818e-05	9.52393e-05	1	1	0
LRRC55	219527	broad.mit.edu	37	11	56950004	56950004	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:56950004A>G	ENST00000497933.1	+	1	784	c.637A>G	c.(637-639)Agt>Ggt	p.S213G		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	183	LRRCT.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						CCTGGACCTCAGTTATGGGGG	0.652000													12	38					0	0	1	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58190197	58190197	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr19:58190197C>G	ENST00000318203.5	+	5	1923	c.1226C>G	c.(1225-1227)tCc>tGc	p.S409C		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	409					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CGCCAGTCATCCACATACCAC	0.473000													25	71					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196392206	196392206	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:196392206G>A	ENST00000367433.5	-	12	1260	c.1159C>T	c.(1159-1161)Cgt>Tgt	p.R387C	KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000294725.8_Missense_Mutation_p.R387C|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000367431.4_Missense_Mutation_p.R387C			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	387						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						ACTTCACAACGGCTACTGAGA	0.308000													11	25					0	0	1	0	0
NXPE4	54827	broad.mit.edu	37	11	114442009	114442009	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:114442009G>T	ENST00000375478.3	-	6	1466	c.1286C>A	c.(1285-1287)aCt>aAt	p.T429N	NXPE4_ENST00000424261.2_Missense_Mutation_p.T145N	NM_001077639.1	NP_001071107.1			neurexophilin and PC-esterase domain family, member 4																		AACAATGACAGTATTTTTTTC	0.428000													5	133					0.00116845	0.00131592	1	1	0
DET1	55070	broad.mit.edu	37	15	89074818	89074818	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr15:89074818C>T	ENST00000564406.1	-	3	312	c.152G>A	c.(151-153)cGa>cAa	p.R51Q	DET1_ENST00000444300.1_Missense_Mutation_p.R51Q|DET1_ENST00000558413.1_Intron|DET1_ENST00000268148.8_Missense_Mutation_p.R40Q	NM_017996.3	NP_060466.2	Q7L5Y6	DET1_HUMAN	de-etiolated homolog 1 (Arabidopsis)	40						nucleus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Lung NSC(78;0.105)|all_lung(78;0.182)		BRCA - Breast invasive adenocarcinoma(143;0.188)			ATGGAACACTCGGACTTGGTG	0.483000													11	61					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57754537	57754537	+	Silent	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr17:57754537G>T	ENST00000269122.3	+	17	3058	c.2784G>T	c.(2782-2784)ctG>ctT	p.L928L	CLTC_ENST00000393043.1_Silent_p.L928L|CLTC_ENST00000579456.1_Intron	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	928	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					AATGTGATCTGGAACTTATTA	0.398000			T	"""ALK, TFE3"""	"""ALCL, renal """								6	46					0.00198382	0.00217097	1	1	0
ERI2	112479	broad.mit.edu	37	16	20814811	20814811	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr16:20814811A>G	ENST00000357967.4	-	3	161	c.119T>C	c.(118-120)aTt>aCt	p.I40T	ERI2_ENST00000564349.1_5'UTR|ERI2_ENST00000563117.1_5'UTR|ERI2_ENST00000300005.3_Missense_Mutation_p.I40T|ERI2_ENST00000569729.1_Missense_Mutation_p.I40T|ERI2_ENST00000389345.5_5'UTR	NM_001142725.1	NP_001136197.1	A8K979	ERI2_HUMAN	ERI1 exoribonuclease family member 2	40	Exonuclease.					intracellular	exonuclease activity|nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(2)	11						TTCAAAATCAATGACAATTAA	0.408000													22	35					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545234	82545234	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr7:82545234C>T	ENST00000423517.2	-	7	12405	c.12068G>A	c.(12067-12069)aGc>aAc	p.S4023N	PCLO_ENST00000333891.8_Missense_Mutation_p.S4023N|PCLO_ENST00000437081.1_Missense_Mutation_p.S743N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3954					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TATTGGACTGCTTGCCATGCT	0.393000													38	57					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24526684	24526684	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:24526684G>A	ENST00000355123.4	-	9	1284	c.841C>T	c.(841-843)Cag>Tag	p.Q281*	ITSN2_ENST00000406921.3_Nonsense_Mutation_p.Q281*|ITSN2_ENST00000361999.3_Nonsense_Mutation_p.Q281*	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	281	EH 2.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTAGCCAGCTGAGTTTGAGAA	0.313000													15	36					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46313221	46313221	+	Missense_Mutation	SNP	C	C	T	rs116302994	byFrequency	TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr20:46313221C>T	ENST00000359930.4	-	6	1693	c.842G>A	c.(841-843)cGg>cAg	p.R281Q	SULF2_ENST00000484875.1_Missense_Mutation_p.R281Q|SULF2_ENST00000467815.1_Missense_Mutation_p.R281Q|SULF2_ENST00000361612.4_Missense_Mutation_p.R281Q|CTD-2653D5.1_ENST00000526566.2_RNA	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	281					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CAAGCGCTTCCGCTGGAGCAT	0.627000													4	9					0	0	1	0	0
AKT3	10000	broad.mit.edu	37	1	243809322	243809322	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:243809322G>C	ENST00000366539.1	-	5	502	c.302C>G	c.(301-303)gCt>gGt	p.A101G	AKT3_ENST00000366540.1_Missense_Mutation_p.A101G|AKT3_ENST00000336199.5_Missense_Mutation_p.A101G|AKT3_ENST00000263826.5_Missense_Mutation_p.A101G			Q9Y243	AKT3_HUMAN	v-akt murine thymoma viral oncogene homolog 3	101	PH.				signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|skin(3)|stomach(1)	26	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			AGCCTGGATAGCTTCTGTCCA	0.333000													11	26					0	0	1	0	0
KDM5A	5927	broad.mit.edu	37	12	416934	416934	+	Nonsense_Mutation	SNP	T	T	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr12:416934T>A	ENST00000399788.2	-	23	3978	c.3616A>T	c.(3616-3618)Aaa>Taa	p.K1206*	KDM5A_ENST00000382815.4_Nonsense_Mutation_p.K1206*	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1206					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						TTTACTTCTTTAGCTTGCCAG	0.463000			T	NUP98	AML								30	75					0	0	1	0	0
CCT8	10694	broad.mit.edu	37	21	30439992	30439992	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr21:30439992G>A	ENST00000286788.4	-	4	472	c.266C>T	c.(265-267)gCt>gTt	p.A89V	CCT8_ENST00000542732.1_Missense_Mutation_p.A70V|CCT8_ENST00000540844.1_Missense_Mutation_p.A16V|CCT8_ENST00000470450.1_5'UTR	NM_006585.2	NP_006576.2	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	89					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|prostate(3)	14						CATATGAGAAGCCATTACAAT	0.388000													10	47					0	0	1	0	0
PALD1	27143	broad.mit.edu	37	10	72289648	72289648	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr10:72289648C>T	ENST00000263563.6	+	4	560	c.292C>T	c.(292-294)Cgc>Tgc	p.R98C		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		CTGCCAGGGCCGCTACTTCCT	0.642000													14	17					0	0	1	0	0
AATK	9625	broad.mit.edu	37	17	79092217	79092217	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr17:79092217C>G	ENST00000326724.4	-	14	4134	c.4110G>C	c.(4108-4110)gaG>gaC	p.E1370D	AATK_ENST00000417379.1_Missense_Mutation_p.E1267D	NM_001080395.2	NP_001073864.2	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	1370						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(2)|lung(8)|ovary(3)|prostate(1)|stomach(4)|upper_aerodigestive_tract(1)	21	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CCTCTTTACTCTCACCCCCGG	0.647000													5	8					0	0	1	0	0
TMEM180	79847	broad.mit.edu	37	10	104228878	104228878	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr10:104228878A>C	ENST00000238936.4	+	3	329	c.92A>C	c.(91-93)aAt>aCt	p.N31T	TMEM180_ENST00000369931.3_Missense_Mutation_p.N31T|TMEM180_ENST00000450947.2_3'UTR|TMEM180_ENST00000366277.2_5'UTR	NM_024789.3	NP_079065.2	Q14CX5	TM180_HUMAN	transmembrane protein 180	31						integral to membrane				breast(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|skin(1)	13		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ATCCTGCACAATGTCTTCCTG	0.577000													10	41					0	0	1	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122348981	122348981	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr10:122348981G>T	ENST00000398250.1	+	7	1135	c.783G>T	c.(781-783)ttG>ttT	p.L261F	PPAPDC1A_ENST00000439221.1_Missense_Mutation_p.L198F|PPAPDC1A_ENST00000398248.1_3'UTR|PPAPDC1A_ENST00000369073.3_Missense_Mutation_p.L251F	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	261					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		CACCCAGCTTGCCTCTGGAGG	0.572000													15	32					0.000219431	0.00025454	1	1	0
SLC8A3	6547	broad.mit.edu	37	14	70634287	70634287	+	Missense_Mutation	SNP	T	T	A	rs143972110	byFrequency	TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:70634287T>A	ENST00000381269.2	-	2	1606	c.853A>T	c.(853-855)Att>Ttt	p.I285F	SLC8A3_ENST00000534137.1_Missense_Mutation_p.I285F|SLC8A3_ENST00000528359.1_Missense_Mutation_p.I285F|SLC8A3_ENST00000357887.3_Missense_Mutation_p.I285F|SLC8A3_ENST00000356921.2_Missense_Mutation_p.I285F	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	285					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCCATCTCAATGCCCTTAGGG	0.473000													7	45					0	0	1	0	0
SLC2A3	6515	broad.mit.edu	37	12	8086490	8086490	+	Silent	SNP	T	T	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr12:8086490T>A	ENST00000075120.7	-	2	264	c.24A>T	c.(22-24)ccA>ccT	p.P8P		NM_006931.2	NP_008862.1	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 3	8					carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity	p.P8P(1)		central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(14)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				Kidney(36;0.0866)		ATATCAGAGCTGGGGTGACCT	0.453000													10	39					0	0	1	0	0
SPEM1	374768	broad.mit.edu	37	17	7324689	7324689	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr17:7324689C>A	ENST00000323675.3	+	3	720	c.695C>A	c.(694-696)gCg>gAg	p.A232E	RP11-104H15.7_ENST00000575310.1_RNA	NM_199339.2	NP_955371.2	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	232					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	12		Prostate(122;0.173)				GAGGCAGAGGCGGCTCAGTAC	0.647000													9	20					0.00621372	0.00655265	1	1	0
IGDCC4	57722	broad.mit.edu	37	15	65703655	65703655	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr15:65703655G>T	ENST00000352385.2	-	2	333	c.124C>A	c.(124-126)Cca>Aca	p.P42T		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	42	Ig-like C2-type 1.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						ACTTGCAGTGGCCCCACTCCA	0.647000													5	15					0.217242	0.217242	1	1	0
CXorf56	63932	broad.mit.edu	37	X	118678353	118678353	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chrX:118678353G>A	ENST00000320339.4	-	4	510	c.239C>T	c.(238-240)aCg>aTg	p.T80M	CXorf56_ENST00000486230.1_Missense_Mutation_p.T129M|CXorf56_ENST00000371594.4_Missense_Mutation_p.T129M|CXorf56_ENST00000476164.1_Missense_Mutation_p.T129M|CXorf56_ENST00000536133.1_Missense_Mutation_p.T115M	NM_001170569.1	NP_001164040.1	Q9H5V9	CX056_HUMAN	chromosome X open reading frame 56	129							protein binding			cervix(1)|endometrium(2)|lung(7)	10						ATATATGTTCGTTTTCCCAAA	0.423000													28	66					0	0	1	0	0
GCFC2	6936	broad.mit.edu	37	2	75917824	75917824	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:75917824C>G	ENST00000321027.3	-	8	1299	c.1166G>C	c.(1165-1167)aGt>aCt	p.S389T	MRPL19_ENST00000358788.6_3'UTR|GCFC2_ENST00000409857.3_Missense_Mutation_p.S351T|GCFC2_ENST00000541687.1_3'UTR	NM_001201334.1|NM_003203.4	NP_001188263.1|NP_003194.3	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	389					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										GAAGTTTCCACTTGTGGATGT	0.289000													23	83					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39815268	39815268	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:39815268C>G	ENST00000564288.1	+	42	11711	c.10934C>G	c.(10933-10935)tCt>tGt	p.S3645C	MACF1_ENST00000361689.2_Missense_Mutation_p.S1583C|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000567887.1_Missense_Mutation_p.S3682C|MACF1_ENST00000372915.3_Missense_Mutation_p.S3650C|MACF1_ENST00000289893.4_Missense_Mutation_p.S2085C|MACF1_ENST00000539005.1_Missense_Mutation_p.S1583C|MACF1_ENST00000317713.7_Missense_Mutation_p.S1583C|MACF1_ENST00000545844.1_Missense_Mutation_p.S1583C			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3650					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGGATCTCTCTGCTTTGCAG	0.498000													16	31					0	0	1	0	0
FBXO21	23014	broad.mit.edu	37	12	117603333	117603333	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr12:117603333A>C	ENST00000427718.2	-	9	1357	c.1283T>G	c.(1282-1284)cTc>cGc	p.L428R	FBXO21_ENST00000330622.5_Missense_Mutation_p.L428R	NM_015002.2|NM_033624.2	NP_055817.1|NP_296373.1	O94952	FBX21_HUMAN	F-box protein 21	428					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(4)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|pancreas(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	29	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		CCTGGCTTGGAGGAGGAGAAG	0.502000													24	55					0	0	1	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179820467	179820467	+	Silent	SNP	T	T	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:179820467T>A	ENST00000367612.3	-	4	453	c.66A>T	c.(64-66)tcA>tcT	p.S22S		NM_001199260.1|NM_145034.4	NP_001186189.1|NP_659471.1	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	22						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(10)|ovary(1)|skin(2)	18						GAGAATTTACTGATGGATCAT	0.368000													4	68					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92590447	92590447	+	Silent	SNP	C	C	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:92590447C>A	ENST00000298047.6	+	19	11450	c.11433C>A	c.(11431-11433)gtC>gtA	p.V3811V	FAT3_ENST00000533797.1_Silent_p.V146V|FAT3_ENST00000525166.1_Silent_p.V3661V|FAT3_ENST00000409404.2_Silent_p.V3811V			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3811	EGF-like 1.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGCAGTGTGTCAGTTATGAAG	0.542000										TCGA Ovarian(4;0.039)			7	34					0.00621372	0.00655265	1	1	0
Z97634.5	0	broad.mit.edu	37	16	437314	437314	+	RNA	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr16:437314G>T	ENST00000412293.1	+	0	521					NR_024453.2																						gccaagcatggtggcatgtgt	0.438000													3	6					6.4e-05	7.57551e-05	1	1	0
NR3C2	0	broad.mit.edu	37	4	149181195	149181195	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr4:149181195G>A	ENST00000355292.3	-	3	2194	c.1832C>T	c.(1831-1833)tCa>tTa	p.S611L	NR3C2_ENST00000342437.4_Missense_Mutation_p.S611L|NR3C2_ENST00000358102.3_Missense_Mutation_p.S611L|NR3C2_ENST00000344721.4_Missense_Mutation_p.S611L|NR3C2_ENST00000511528.1_Missense_Mutation_p.S611L|NR3C2_ENST00000512865.1_Missense_Mutation_p.S611L			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	611					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ATGGCATCCTGAAGCCTCATC	0.403000													13	78					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41745622	41745622	+	Silent	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr19:41745622C>T	ENST00000301178.4	+	10	1499	c.1309C>T	c.(1309-1311)Ctg>Ttg	p.L437L	AXL_ENST00000593513.1_Silent_p.L169L|AXL_ENST00000359092.3_Intron	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	437						integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						AGTCCACCAGCTGGGTAAGGG	0.552000													17	116					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161789484	161789484	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr1:161789484G>A	ENST00000367942.3	+	8	1038	c.971G>A	c.(970-972)cGc>cAc	p.R324H		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	324					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TGTCAGTCTCGCAAGAAGAAG	0.403000													6	58					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	87878731	87878731	+	Missense_Mutation	SNP	T	T	C	rs113899610		TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr8:87878731T>C	ENST00000518476.1	+	1	59	c.8T>C	c.(7-9)aTg>aCg	p.M3T		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	3										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						AAGATGCCGATGTCTTCTCTT	0.458000													5	20					0	0	1	0	0
KIRREL2	84063	broad.mit.edu	37	19	36348367	36348367	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr19:36348367T>A	ENST00000360202.5	+	2	380	c.182T>A	c.(181-183)cTg>cAg	p.L61Q	KIRREL2_ENST00000262625.7_Missense_Mutation_p.L61Q|KIRREL2_ENST00000586102.2_Missense_Mutation_p.L61Q|KIRREL2_ENST00000347900.6_Intron|KIRREL2_ENST00000592409.1_Missense_Mutation_p.L61Q|NPHS1_ENST00000591817.1_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	61	Ig-like C2-type 1.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGAGTGGGCTGGCCCTAGGG	0.652000													16	58					0	0	1	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117432749	117432749	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr7:117432749G>T	ENST00000160373.3	-	4	592	c.501C>A	c.(499-501)aaC>aaA	p.N167K	CTTNBP2_ENST00000487820.1_5'UTR	NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	167										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CCACCTGCTTGTTCTTGCCAC	0.522000													16	78					5.01169e-05	5.99337e-05	1	1	0
SEC24C	9632	broad.mit.edu	37	10	75529481	75529481	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr10:75529481C>G	ENST00000339365.2	+	20	2834	c.2672C>G	c.(2671-2673)tCt>tGt	p.S891C	SEC24C_ENST00000540668.1_Missense_Mutation_p.S139C|SEC24C_ENST00000535742.1_Missense_Mutation_p.S139C|SEC24C_ENST00000496827.1_3'UTR|SEC24C_ENST00000345254.4_Missense_Mutation_p.S891C|SEC24C_ENST00000411652.2_Missense_Mutation_p.S772C	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	891					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					AGCCCCTCCTCTGCAGGACAG	0.502000													6	52					0	0	1	0	0
GNAI2	2771	broad.mit.edu	37	3	50290538	50290538	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr3:50290538G>A	ENST00000313601.6	+	4	770	c.386G>A	c.(385-387)cGg>cAg	p.R129Q	GNAI2_ENST00000536647.1_Missense_Mutation_p.R48Q|GNAI2_ENST00000491100.1_3'UTR|GNAI2_ENST00000440628.1_Missense_Mutation_p.R77Q|GNAI2_ENST00000266027.5_Missense_Mutation_p.R113Q|GNAI2_ENST00000422163.1_Missense_Mutation_p.R113Q|GNAI2_ENST00000451956.1_Missense_Mutation_p.R92Q	NM_002070.2	NP_002061.1	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	129					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|liver(2)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		GGCGTCATCCGGAGGCTCTGG	0.642000													57	127					0	0	1	0	0
PLA2G7	7941	broad.mit.edu	37	6	46678365	46678365	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr6:46678365C>T	ENST00000274793.7	-	8	890	c.694G>A	c.(694-696)Gct>Act	p.A232T	PLA2G7_ENST00000541026.1_Missense_Mutation_p.A105T|PLA2G7_ENST00000537365.1_Missense_Mutation_p.A232T|PLA2G7_ENST00000538237.1_Missense_Mutation_p.A187T	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	232					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			AGACTGAGAGCTTGGGAACAT	0.313000													16	39					0	0	1	0	0
RNF32	140545	broad.mit.edu	37	7	156469181	156469181	+	Silent	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr7:156469181C>T	ENST00000405335.1	+	10	1330	c.921C>T	c.(919-921)cgC>cgT	p.R307R	RNF32_ENST00000392743.2_Silent_p.R307R|RNF32_ENST00000343665.4_Silent_p.R283R|RNF32_ENST00000317955.5_Silent_p.R307R|RNF32_ENST00000311822.8_3'UTR|RNF32_ENST00000432459.2_Silent_p.R307R|AC005534.9_ENST00000430825.1_RNA			Q9H0A6	RNF32_HUMAN	ring finger protein 32	307			R -> C (in dbSNP:rs2302146).			aggresome|endosome	protein binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(2)	15	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GCGGTCAGCGCGTGGGTGCAG	0.667000													6	20					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74315728	74315728	+	Silent	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr3:74315728G>A	ENST00000263665.6	-	21	2917	c.2890C>T	c.(2890-2892)Ctg>Ttg	p.L964L	CNTN3_ENST00000477856.1_5'UTR	NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	964	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding	p.L964M(1)		NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TTAATGGGCAGCACAAGTTCA	0.393000													4	140					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810767	7810767	+	Missense_Mutation	SNP	G	G	A	rs146082308		TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr19:7810767G>A	ENST00000315599.7	-	4	407	c.385C>T	c.(385-387)Cgg>Tgg	p.R129W	CD209_ENST00000301357.8_Missense_Mutation_p.R85W|CD209_ENST00000394161.5_Intron|CD209_ENST00000602261.1_Missense_Mutation_p.R129W|CD209_ENST00000593660.1_Missense_Mutation_p.R105W|CD209_ENST00000601951.1_Missense_Mutation_p.R105W|CD209_ENST00000315591.8_Missense_Mutation_p.R105W|CD209_ENST00000204801.8_Missense_Mutation_p.R85W|CD209_ENST00000601256.1_Missense_Mutation_p.R105W|CD209_ENST00000593821.1_Missense_Mutation_p.R85W|CD209_ENST00000394173.4_Intron|CD209_ENST00000354397.6_Missense_Mutation_p.R129W	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	129	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.R129W(4)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCCTTCAGCCGGGTCAGCTCC	0.567000													5	155					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271515	1271515	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:1271515G>A	ENST00000447027.1	+	31	13472	c.13414G>A	c.(13414-13416)Gcc>Acc	p.A4472T	MUC5B_ENST00000529681.1_Missense_Mutation_p.A4469T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4469	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACGGCCACCGCCTCCTCCAC	0.672000													19	63					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224462648	224462648	+	Silent	SNP	C	C	T	rs143843249	byFrequency	TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:224462648C>T	ENST00000305409.2	-	2	1585	c.1353G>A	c.(1351-1353)tcG>tcA	p.S451S		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	451					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGGGAAAATACGACGTTTTCT	0.488000													26	61					0	0	1	0	0
POTEM	641455	broad.mit.edu	37	14	20010235	20010235	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:20010235A>G	ENST00000551509.1	-	5	974	c.923T>C	c.(922-924)gTt>gCt	p.V308A	RP11-244H18.1_ENST00000547584.1_lincRNA	NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	308										endometrium(4)|kidney(1)|lung(4)	9						AAGTATGAGAACAGTTCTAAA	0.368000													3	56					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370935	126370935	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr4:126370935G>T	ENST00000394329.3	+	9	8777	c.8764G>T	c.(8764-8766)Gcc>Tcc	p.A2922S	FAT4_ENST00000335110.5_Missense_Mutation_p.A1220S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2922	Cadherin 28.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAGGATTAATGCCACCACTGG	0.348000													27	54					1.77063e-15	2.25707e-15	1	1	0
MUT	4594	broad.mit.edu	37	6	49425723	49425723	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr6:49425723C>A	ENST00000274813.3	-	3	561	c.434G>T	c.(433-435)gGc>gTc	p.G145V		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	145			G -> S (in MMAM; mut0).		fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGAATCATAGCCACGATGTGT	0.403000													21	48					3.28513e-13	4.09758e-13	1	1	0
ITPRIP	85450	broad.mit.edu	37	10	106075031	106075031	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr10:106075031G>T	ENST00000278071.2	-	3	1231	c.779C>A	c.(778-780)aCc>aAc	p.T260N	ITPRIP_ENST00000337478.1_Missense_Mutation_p.T260N|ITPRIP_ENST00000358187.2_Missense_Mutation_p.T260N	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	260						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						CCCGAGCTTGGTCTTGCCGCA	0.642000													5	47					3.59834e-05	4.34799e-05	1	1	0
PI4KA	5297	broad.mit.edu	37	22	21167790	21167790	+	Silent	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr22:21167790G>A	ENST00000255882.6	-	8	947	c.861C>T	c.(859-861)tcC>tcT	p.S287S	PI4KA_ENST00000572273.1_Silent_p.S229S	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	229					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CGGGCAAGCAGGAGGCTGGTG	0.517000													3	31					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4967661	4967661	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:4967661T>C	ENST00000380373.2	-	1	695	c.670A>G	c.(670-672)Aag>Gag	p.K224E	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTACAGTCTTGAGGATCAGG	0.423000													9	34					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240713	3240713	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chrX:3240713G>T	ENST00000217939.6	-	5	3167	c.3013C>A	c.(3013-3015)Ccc>Acc	p.P1005T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1005						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CAGATGGTGGGGGTTGGAGTA	0.463000													16	39					6.94344e-10	8.5685e-10	1	1	0
KCNE3	10008	broad.mit.edu	37	11	74168427	74168427	+	Missense_Mutation	SNP	A	A	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:74168427A>T	ENST00000310128.4	-	3	601	c.182T>A	c.(181-183)aTt>aAt	p.I61N	KCNE3_ENST00000525550.1_Missense_Mutation_p.I61N|RP11-702H23.4_ENST00000533008.1_RNA	NM_005472.4	NP_005463.1	Q9Y6H6	KCNE3_HUMAN	potassium voltage-gated channel, Isk-related family, member 3	61						integral to membrane	voltage-gated potassium channel activity			cervix(1)|large_intestine(1)|lung(1)|ovary(1)	4	Breast(11;2.86e-06)					GACAAAGAGAATGTACATGTA	0.557000													9	28					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39760856	39760856	+	Silent	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr12:39760856G>A	ENST00000395670.3	-	5	1130	c.711C>T	c.(709-711)acC>acT	p.T237T	KIF21A_ENST00000361418.5_Silent_p.T237T|KIF21A_ENST00000541463.2_Silent_p.T237T|KIF21A_ENST00000544797.2_Silent_p.T237T|KIF21A_ENST00000361961.3_Silent_p.T237T			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	237	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				GACACACTCTGGTTTGACACA	0.378000													6	46					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129636711	129636711	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr6:129636711G>C	ENST00000421865.2	+	25	3695	c.3646G>C	c.(3646-3648)Gag>Cag	p.E1216Q		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1216	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCAACATCCAGAGATTGTTGC	0.473000													3	73					0	0	1	0	0
NFAM1	150372	broad.mit.edu	37	22	42807644	42807644	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr22:42807644G>T	ENST00000329021.5	-	2	257	c.220C>A	c.(220-222)Caa>Aaa	p.Q74K		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	74	Ig-like V-type.				B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			large_intestine(1)|lung(3)	4						ACCTTGAATTGGGGAGTGTAT	0.542000													5	58					0.0215528	0.022125	1	1	0
COL4A3BP	10087	broad.mit.edu	37	5	74685512	74685512	+	Splice_Site	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr5:74685512C>G	ENST00000380494.5	-	13	1866	c.1572_splice	c.e13-1	p.V525_splice	COL4A3BP_ENST00000261415.7_Splice_Site_p.V371_splice|COL4A3BP_ENST00000405807.4_Splice_Site_p.V397_splice	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	397	START.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		ATCTCTTCAACCTTGAGAAGG	0.408000													11	16					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65343824	65343824	+	Silent	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr11:65343824G>A	ENST00000309295.4	+	1	316	c.51G>A	c.(49-51)aaG>aaA	p.K17K		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	17										central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						GGGCGGCCAAGTTCCAGTTCG	0.692000													3	3					0	0	1	0	0
MUT	4594	broad.mit.edu	37	6	49425724	49425724	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr6:49425724C>A	ENST00000274813.3	-	3	560	c.433G>T	c.(433-435)Ggc>Tgc	p.G145C		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	145			G -> S (in MMAM; mut0).		fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAATCATAGCCACGATGTGTC	0.403000													21	47					1.64293e-13	2.07152e-13	1	1	0
ARHGAP9	64333	broad.mit.edu	37	12	57866445	57866445	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr12:57866445C>T	ENST00000393797.2	-	21	2513	c.2321G>A	c.(2320-2322)cGc>cAc	p.R774H	ARHGAP9_ENST00000393791.3_Missense_Mutation_p.R684H|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.R500H|ARHGAP9_ENST00000424809.2_3'UTR|ARHGAP9_ENST00000550288.1_3'UTR|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.R703H			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	703					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			GGGTGTCATGCGATTCTTATC	0.517000													15	33					0	0	1	0	0
CEP120	153241	broad.mit.edu	37	5	122717825	122717825	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr5:122717825C>G	ENST00000306467.5	-	14	2387	c.2083G>C	c.(2083-2085)Gaa>Caa	p.E695Q	CEP120_ENST00000306481.6_Missense_Mutation_p.E669Q|CEP120_ENST00000328236.5_Missense_Mutation_p.E695Q			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	695						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						ACTAGTGATTCTCTTTCTCGG	0.363000													18	79					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36691745	36691745	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:36691745C>G	ENST00000280527.2	+	5	1305	c.938C>G	c.(937-939)tCt>tGt	p.S313C		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	313					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				CGCATAGTCTCTCGTGGCGAT	0.498000													14	90					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101587521	101587521	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr12:101587521G>C	ENST00000536262.2	-	5	1132	c.574C>G	c.(574-576)Caa>Gaa	p.Q192E		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	192					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						ATCCCAACTTGAAAAACATCT	0.398000													4	88					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													3	25					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45645392	45645392	+	Silent	SNP	C	C	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr14:45645392C>T	ENST00000267430.5	+	14	3520	c.3435C>T	c.(3433-3435)gaC>gaT	p.D1145D	FANCM_ENST00000542564.2_Silent_p.D1119D	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1145					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						CAGAGTTCGACGATGTGAGTC	0.388000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				30	61					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11955224	11955224	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr2:11955224A>T	ENST00000256720.2	+	17	2245	c.2152A>T	c.(2152-2154)Aaa>Taa	p.K718*	LPIN1_ENST00000404113.2_Nonsense_Mutation_p.K219*|LPIN1_ENST00000396097.1_Nonsense_Mutation_p.K448*|LPIN1_ENST00000449576.2_Nonsense_Mutation_p.K803*|LPIN1_ENST00000425416.2_Nonsense_Mutation_p.K724*|LPIN1_ENST00000396099.1_Nonsense_Mutation_p.K760*	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	718	C-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		GAATGGATATAAATTTCTCTA	0.502000													3	33					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110420367	110420367	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr8:110420367G>T	ENST00000378402.5	+	18	2007	c.1903G>T	c.(1903-1905)Gag>Tag	p.E635*		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	635					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACCCAACTTGGAGACATTCAC	0.413000										HNSCC(38;0.096)			6	49					0.0215528	0.022125	1	1	0
CDH8	1006	broad.mit.edu	37	16	61689558	61689558	+	Silent	SNP	T	T	C			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr16:61689558T>C	ENST00000577390.1	-	11	2676	c.1722A>G	c.(1720-1722)ttA>ttG	p.L574L	CDH8_ENST00000577730.1_Silent_p.L574L|CDH8_ENST00000299345.6_Silent_p.L574L	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	574	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTATGATTGGTAAAAGATAGA	0.408000													8	39					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47084145	47084146	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr3:47084145_47084146insG	ENST00000409792.3	-	17	7185_7186	c.7143_7144insC	c.(7141-7146)ccctccfs	p.S2382fs		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2382					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.P2380fs(2)|p.P1877fs(2)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTGGGAGGAGAGGGGGGCGGCA	0.426			"""N, F, S, Mis"""		clear cell renal carcinoma								16	61	---	---	---	---					
RP11-297P16.3	0	broad.mit.edu	37	4	104493231	104493231	+	RNA	DEL	G	G	-			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr4:104493231delG	ENST00000502936.1	+	0	189				RP11-297P16.3_ENST00000512401.1_RNA																							GAAGACTCCTGGGTACTCTTC	0.448													2	4	---	---	---	---					
IL9	3578	broad.mit.edu	37	5	135231281	135231281	+	Splice_Site	DEL	T	T	-			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr5:135231281delT	ENST00000274520.1	-	2	125		c.e2-2			NM_000590.1	NP_000581.1	P15248	IL9_HUMAN	interleukin 9						immune response|inflammatory response|positive regulation of cell proliferation|positive regulation of interleukin-5 biosynthetic process	extracellular space	cytokine activity|cytokine receptor binding|growth factor activity			large_intestine(3)|lung(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGGATCTTCCTAAAGTAGATA	0.403													12	119	---	---	---	---					
RARS2	57038	broad.mit.edu	37	6	88240657	88240657	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr6:88240657delA	ENST00000369536.5	-	9	661	c.616delT	c.(616-618)atfs	p.Y206fs		NM_020320.3	NP_064716.2	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	206					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		ACTTGTACATAAACCTAAAAG	0.363													15	27	---	---	---	---					
MPLKIP	136647	broad.mit.edu	37	7	40174134	40174134	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr7:40174134delA	ENST00000306984.5	-	1	124	c.33delT	c.(31-33)ccfs	p.P12fs		NM_138701.3	NP_619646.1	Q8TAP9	TTDN1_HUMAN	M-phase specific PLK1 interacting protein	12					cell division|mitosis	microtubule organizing center|nucleus											CAGGGTAAGGAGGAGTTGGGG	0.667													2	4	---	---	---	---					
MAFA	389692	broad.mit.edu	37	8	144511954	144511956	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr8:144511954_144511956delTGG	ENST00000333480.2	-	1	620_622	c.621_623delCCA	c.(619-624)cat>ca	p.HH207del	MAFA_ENST00000528185.1_5'UTR	NM_201589.3	NP_963883.2	Q8NHW3	MAFA_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	207	His-rich.				insulin secretion|nitric oxide mediated signal transduction|response to glucose stimulus	nucleus	protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.H208delH(3)		breast(1)|lung(1)|upper_aerodigestive_tract(2)	4	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.237)			CGCGCCGCCAtggtggtggtggt	0.744										HNSCC(29;0.082)			3	5	---	---	---	---					
QSOX2	169714	broad.mit.edu	37	9	139115851	139115855	+	Splice_Site	DEL	ACTGA	ACTGA	-			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr9:139115851_139115855delACTGA	ENST00000358701.5	-	4	619_622	c.584_splice	c.e4+1	p.194_splice		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	194					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		GGAGCTACTCACTGAATGGGGTCTA	0.551													23	59	---	---	---	---					
AC012313.1	0	broad.mit.edu	37	19	58907569	58907571	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr19:58907569_58907571delAGG	ENST00000601382.1	+	1	113_115	c.113_115delAGG	c.(112-117)cag>c	p.38del		NM_001195135.1	NP_001182064.1																					GGGGAAGACCaggaggaggagga	0.724													2	4	---	---	---	---					
MX2	4600	broad.mit.edu	37	21	42771265	42771268	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-ZG-A9NI-01A-11D-A41K-08	TCGA-ZG-A9NI-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	22868fe7-004f-48cc-ac4e-975a7ec1b9f9	110f12ed-ca50-4832-bba5-acdccedd3746	g.chr21:42771265_42771268delGTAA	ENST00000330714.3	+	10	1598		c.e10+1		MX2_ENST00000496774.1_Splice_Site	NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)						response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				ACCCAAAAAGGTAAGTTCTGGGCA	0.456													17	85	---	---	---	---